The agricultural industry has undergone several significant changes over the past few centuries, influenced by the industrial revolutions that have occurred. These changes have progressed from Indigenous agriculture to mechanized farming and the current precision agriculture. While the industrial farming model has increased output, it has also faced various challenges in recent years. Industry 5.0 is expected to have a significant impact on the agriculture sector and potentially lead to a fifth agricultural revolution. In this paper, we examine the motivation behind the industrial and agricultural revolutions 4.0 and 5.0, review the phases of these revolutions that have occurred so far, and offer suggestions for the future. We also provide an overview of the concepts of Industry 4.0 and 5.0, as well as Agriculture 4.0 and 5.0, and discuss the smart strategies that are being implemented in different countries to advance these sectors. Additionally, we focus on the potential applications of Industry 5.0 technologies in the agriculture industry and the research challenges associated with them. Our goal is to provide industrial and agricultural professionals with new research opportunities. Full article

In this study, a rutabaga (Brassica napus ssp. napobrassica) donor parent FGRA106, which exhibited broad-spectrum resistance to 17 isolates representing 16 pathotypes of Plasmodiophora brassicae, was used in genetic crosses with the susceptible spring-type canola (B. napus ssp. napus) accession FG769. The F₂ plants derived from a clubroot-resistant F₁ plant were screened against three P. brassicae isolates representing pathotypes 3A, 3D, and 3H. Chi-square (χ²) goodness-of-fit tests indicated that the F₂ plants inherited two major clubroot resistance genes from the CR donor FGRA106. The total RNA from plants resistant (R) and susceptible (S) to each pathotype were pooled and subjected to bulked segregant RNA-sequencing (BSR-Seq). The analysis of gene expression profiles identified 431, 67, and 98 differentially expressed genes (DEGs) between the R and S bulks. The variant calling method indicated a total of 12 (7 major + 5 minor) QTLs across seven chromosomes. The seven major QTLs included: BnaA5P3A.CRX1.1, BnaC1P3H.CRX1.2, and BnaC7P3A.CRX1.1 on chromosomes A05, C01, and C07, respectively; and BnaA8P3D.CRX1.1, BnaA8P3D.RCr91.2/BnaA8P3H.RCr91.2, BnaA8P3H.Crr11.3/BnaA8P3D.Crr11.3, and BnaA8P3D.qBrCR381.4 on chromosome A08. A total of 16 of the DEGs were located in the major QTL regions, 13 of which were on chromosome C07. The molecular data suggested that clubroot resistance in FGRA106 may be controlled by major and minor genes on both the A and C genomes, which are deployed in different combinations to confer resistance to the different isolates. This study provides valuable germplasm for the breeding of clubroot-resistant B. napus cultivars in Western Canada. Full article

Background: Nivolumab has been shown to improve the overall survival (OS) of patients with recurrent and metastatic head and neck squamous cell carcinoma (R/M HNSCC). However, there is a need to identify factors associated with long-term survival (beyond 2 years) in these patients. This study investigated the relationship between pretreatment factors and long-term survival in patients with R/M HNSCC treated with nivolumab. Methods: Forty-nine patients with R/M HNSCC who were treated with nivolumab were retrospectively reviewed. Baseline characteristics, clinical data, and survival outcomes were evaluated. Univariate and multivariate analyses were performed to identify factors associated with long-term survival (OS ≥ 2 years). Results: The median OS in the overall cohort was 11.0 months, and the 2-year survival rate was 34.7%. Long-term survivors (OS ≥ 2 years) had significantly higher proportions of patients with Eastern Cooperative Oncology Group (ECOG) performance status (PS) scores of 0 or 1, serum albumin levels ≥ 3.5 g/dL, and neutrophil-to-eosinophil ratio (NER) < 32.0 compared to non-long-term survivors. On multivariate analysis, serum albumin levels ≥ 3.5 g/dL, in addition to ECOG-PS score of 0 or 1, were independent predictors of long-term survival. Conclusions: Pretreatment serum albumin levels may be useful for predicting long-term survival in R/M HNSCC patients treated with nivolumab. Full article

The Beni region in the eastern Democratic Republic of Congo is grappling with socioeconomic development and security challenges that have affected its natural ecosystems, especially those located in the northern Virunga National Park. This study aims to document the anthropization of the northwestern Virunga landscape from 1995 to 2021 in the context of insecurity. Using a cartographic approach and ecological-landscape-analysis tools, this study delves into the overall landscape changes through a comparative analysis of protected and unprotected areas. These investigations focus on landscape composition, transitions between land-cover classes, and the spatial transformation process. The northwestern Virunga landscape is undergoing significant land cover changes due to the influence of insecurity on socioeconomic activities, primarily agriculture. Agricultural land encompasses a larger area than other land-cover types. However, its expansion has decelerated since the 2000s. The loss of forested area is discontinuous. During relatively stable periods (1995–2005), forests exhibited a reduction of up to 2.90% in area, while in the period of the return of Iturian refugees to their province, followed by terrorist insecurity in Beni (2005–2021), the forested area increased by 2.07%. Savannah areas, which are mainly located in the graben rift valley and near Butembo, have been more heavily affected by human activity than forests. Ultimately, the apparent stability of the landscape can be attributed to its protected areas, especially Virunga National Park. Full article

In recent years, with the development of building technology, the Chinese construction industry has begun to gradually promote the prefabricated buildings to save on construction costs. Among them, composite slabs, as essential components of prefabricated buildings, have been widely used by designers mainly in favor of their low cost. However, is it possible to further reduce the cost without affecting the quality? Researchers think so if the operation cycle of support from the bottom of composite slabs can accelerate and the mechanical properties of their bottom plate can be optimized. To prove this hypothesis, researchers proposed a new type of prestressed concrete composite slab with removable rectangular steel-tube lattice girders (referred to as CDB composite slabs), whose bottom plate consists of a temporary structure composed of a prestressed concrete prefabricated plate and removable rectangular steel-tube lattice girders. Through static bending performance tests on three prefabricated bottom plates and one composite slab, researchers measured corresponding load-displacement curves, load-strain curves, crack development, and distribution, etc. The test results show that the top chord rectangular steel tubes connected to the bottom plate concrete through web reinforcement bars significantly improve the rigidity, crack resistance, and load-bearing capacity of the bottom plate and possess better ductility and out-of-plane stability. The number of supports at the bottom of the bottom plate is effectively reduced, with the maximum unsupported span reaching 4.8 m. Beyond 4.8 m, only one additional support is needed, and the maximum support span can be up to 9.0 m, which provides space for cost reduction. The cooperative load-bearing performance of the prefabricated bottom plate and the post-cast composite layer concrete is good. The top chord rectangular steel tubes are easy to dismantle and can be reused, which reduces the steel consumption by about 24% compared to that used for the same size of ordinary steel-tube lattice-girder concrete composite slabs. It can greatly decrease the cost. In conclusion, the results have shown that the new method researchers proposed here is practically applicable and also provides great space to save on financial costs. Full article

A retrospective study in patients who underwent video capsule endoscopy (VCE) between 2006 and 2016 was conducted in the Clinic for gastroenterology and Hepatology, University Clinical Center of Serbia. A total of 245 patients underwent VCE. In 198 patients the indication was obscure gastrointestinal bleeding (OGIB), with 92 patients having overt and the other 106 occult bleeding. The remaining 47 patients underwent VCE due to suspected small bowel (SB) disease (i.e., Von Hippel–Lindau syndrome, familial adenomatous polyposis, Peutz Jeghers syndrome, Crohn’s disease, prolonged diarrhea, abdominal pain, congenital lymphangiectasia, protein-losing enteropathy, tumors, refractory celiac disease, etc.). VCE identified a source of bleeding in 38.9% of patients (in the obscure overt group in 48.9% of patients, and in the obscure occult group in 30.2% of patients). The most common findings were angiodysplasias, tumors, Meckel’s diverticulum and Crohn’s disease. In the smaller group of patients with an indication other than OGIB, 38.3% of patients had positive VCE findings. The most common indication is OGIB, and the best candidates are patients with overt bleeding; patients with IBD should be evaluated in this setting. Full article

The intense human pressures in the Anthropocene epoch are causing an alarming decline in marine coastal ecosystems and an unprecedented loss of biodiversity. This situation underscores the urgency of making ecological restoration a global priority to recover degraded ecosystems. Meadows of the endemic Mediterranean seagrass Posidonia oceanica have lost more than half of their original extent in the last century, necessitating immediate conservation and management measures, supported by active restoration interventions. This paper explores new opportunities and provides specific recommendations to enhance restoration as a fundamental strategy for reversing the decline of P. oceanica ecosystems in the Mediterranean Sea. When a return to a historical pristine reference condition may not be feasible in the short term or desirable given current environmental conditions and uncertainty, transplanting the tolerant and fast-growing seagrass species Cymodocea nodosa could facilitate natural recolonization. This would occur through secondary ecological succession, benefiting the sensitive and slow-growing species P. oceanica. Future global and local efforts should primarily focus on proactive management to prevent further alterations by planning appropriate conservation measures in a timely manner to mitigate and reverse global changes. As a secondary step, restoration programs can be implemented with a focus on ‘target-oriented’ rather than ‘reference-oriented’ conditions, aiming to establish ecosystems capable of sustaining the future rather than replicating the historical environment. Full article

Non-small cell lung cancer, even when diagnosed in early stages, has been linked with poor survival rates and distant recurrence patterns. Novel therapeutic approaches harnessing the immune system have been implemented in early stages, following the designated steps of advanced NSCLC treatment strategies. Immune-checkpoint inhibitor (ICI) regimens as monotherapy, combinational, or alongside chemotherapy have been intensely investigated as adjuvant, neoadjuvant, and, more recently, perioperative therapeutic strategies, representing pivotal milestones in the evolution of early lung cancer management while holding great potential for the future. The subject of current ongoing research is optimizing treatment outcomes for patient subsets with different needs and identifying biomarkers that could be predictive of response while translating the trials’ endpoints to survival rates. The aim of this review is to discuss all current treatment options with the pros and cons of each, persistent challenges, and future perspectives on immunotherapy as illuminating the path to a new era for resectable NSCLC. Full article

Dihydrochalcones (DHCs) constitute a specific class of flavonoids widely known for their various health-related advantages. Melatonin (MLT) has received attention worldwide as a master regulator in plants, but its roles in DHC accumulation remain unclear. Herein, the elicitation impacts of MLT on DHC biosynthesis were examined in Lithocarpus litseifolius, a valuable medicinal plant famous for its sweet flavor and anti-diabetes effect. Compared to the control, the foliar application of MLT significantly increased total flavonoid and DHC (phlorizin, trilobatin, and phloretin) levels in L. litseifolius leaves, especially when 100 μM MLT was utilized for 14 days. Moreover, antioxidant enzyme activities were boosted after MLT treatments, resulting in a decrease in the levels of intracellular reactive oxygen species. Remarkably, MLT triggered the biosynthesis of numerous phytohormones linked to secondary metabolism (salicylic acid, methyl jasmonic acid (MeJA), and ethylene), while reducing free JA contents in L. litseifolius. Additionally, the flavonoid biosynthetic enzyme activities were enhanced by the MLT in leaves. Multiple differentially expressed genes (DEGs) in RNA-seq might play a crucial role in MLT-elicited pathways, particularly those associated with the antioxidant system (SOD, CAT, and POD), transcription factor regulation (MYBs and bHLHs), and DHC metabolism (4CL, C4H, UGT71K1, and UGT88A1). As a result, MLT enhanced DHC accumulation in L. litseifolius leaves, primarily by modulating the antioxidant activity and co-regulating the physiological, hormonal, and transcriptional pathways of DHC metabolism. Full article

Modelling the volatility of commodity prices and creating more reliable models for estimating and forecasting commodity price returns are crucial. The body of research on statistical models that can fully reflect the empirical characteristics of commodity price returns is lacking. The main aim of this research was to develop a modelling framework that could be used to accurately estimate and forecast commodity price returns by combining long memory models with heavy-tailed distributions. This study employed dual hybrid long-memory generalised autoregressive conditionally heteroscedasticity (GARCH) models with heavy-tailed innovations, namely, the Student-t distribution (StD), skewed-Student-t distribution (SStD), and the generalised error distribution (GED). Based on the smallest forecasting metrics values for mean absolute error (MAE) and mean squared error (MSE) values, the best performing LM-GARCH-type model for lithium is the ARFIMA (1, $\mathcal{o}$, 1)-FIAPARCH (1, $\xi$, 1) with normal innovations. For tobacco, the best model is ARFIMA (1, $\mathcal{o}$, 1)-FIGARCH (1, $\xi$, 1) with SStD innovations. The robust performing model for gold is the ARFIMA (1, $\mathcal{o}$, 1)-FIGARCH (1, $\xi$, 1)-GED model. The best performing forecasting model for crude oil and cotton returns are the $FIAPARCH \left(1,\xi , 1\right)-SStD$ model and $HYGARCH \left(1,\xi , 1\right)-StD$ model, respectively. The results obtained from this study would be beneficial to those concerned with financial market modelling techniques, such as derivative pricing, risk management, asset allocation, and valuation. Full article

(1) Background: Alzheimer’s disease (AD) is characterized by β-amyloid (Aβ) peptide accumulation and mitochondrial dysfunction during the early stage of disease. PINK1 regulates the balance between mitochondrial homeostasis and bioenergy supply and demand via the PINK1/Parkin pathway, Na⁺/Ca²⁺ exchange, and other pathways. (2) Methods: In this study, we synthesized positively charged carbon dots (CA-PEI CDs) using citric acid (CA) and polyethyleneimine (PEI) and used them as vectors to express PINK1 genes in the APP/PS1-N2a cell line to determine mitochondrial function, electron transport chain (ETC) activity, and ATP-related metabolomics. (3) Results: Our findings showed that the CA-PEI CDs exhibit the characteristics of photoluminescence, low toxicity, and concentrated DNA. They are ideal biological carriers for gene delivery. PINK1 overexpression significantly increased the mitochondrial membrane potential in APP/PS1-N2a cells and reduced reactive-oxygen-species generation and Aβ1-40 and Aβ1-42 levels. An increase in the activity of NADH ubiquinone oxidoreductase (complex I, CI) and cytochrome C oxidase (complex IV, CIV) induces the oxidative phosphorylation of mitochondria, increasing ATP generation. (4) Conclusions: These findings indicate that the PINK gene can alleviate AD by increasing bioenergetic metabolism, reducing Aβ1-40 and Aβ1-42, and increasing ATP production. Full article

The endothelial glycocalyx (EGC) is a layer of proteoglycans (associated with glycosaminoglycans) and glycoproteins, which adsorbs plasma proteins on the luminal surface of endothelial cells. Its main function is to participate in separating the circulating blood from the inner layers of the vessels and the surrounding tissues. Physiologically, the EGC stimulates mechanotransduction, the endothelial charge, thrombocyte adhesion, leukocyte tissue recruitment, and molecule extravasation. Hence, severe impairment of the EGC has been implicated in various pathological conditions, including sepsis, diabetes, chronic kidney disease, inflammatory disorders, hypernatremia, hypervolemia, atherosclerosis, and ischemia/reperfusion injury. Moreover, alterations in EGC have been associated with altered responses to therapeutic interventions in conditions such as cardiovascular diseases. Investigation into the function of the glycocalyx has expanded knowledge about vascular disorders and indicated the need to consider new approaches in the treatment of severe endothelial dysfunction. This review aims to present the current understanding of the molecular mechanisms underlying cardiovascular diseases and to elucidate the impact of heart surgery on EGC dysfunction. Full article

Local actions of stressors induce electrical signals (ESs), influencing photosynthetic processes and probably increasing tolerance to adverse factors in higher plants. However, the participation of well-known depolarization ESs (action potentials and variation potentials) in these responses seems to be rare under natural conditions, particularly in the case of variation potentials, which are induced by extreme stressors (e.g., burning). Earlier, we showed that the local action of moderate heating and illumination can induce low-amplitude hyperpolarization ESs influencing photosynthetic light reactions in wheat plants cultivated in a vegetation room. In the current work, we analyzed ESs and changes in photosynthetic light reactions and drought tolerance that were induced by a combination of moderate heating and illumination in wheat plants cultivated under open-ground conditions. It was shown that the local heating and illumination induced low-amplitude ESs, and the type of signal (depolarization or hyperpolarization) was dependent on distance from the irritated zone and wheat age. Induction of depolarization ESs was not accompanied by photosynthetic changes in plants under favorable conditions or under weak drought. In contrast, the changes were observed after induction of these signals under moderate drought. Increasing drought tolerance was also observed in the last case. Thus, low-amplitude ESs can participate in photosynthetic regulation and increase tolerance to drought in plants cultivated under open-ground conditions. Full article

Staphylococcus aureus infections are prevalent in healthcare and community environments. Methicillin-resistant S. aureus is catalogued as a superbug of high priority among the pathogens. This Gram-positive coccus can form biofilms and produce toxins, leading to persistent infection and antibiotic resistance. Limited effective antibiotics have encouraged the development of innovative strategies, with a particular emphasis on resistance mechanisms and/or virulence factors. Medicinal aromatic plants have emerged as promising alternative sources. This study investigated the antimicrobial, antibiofilm, and antihemolysis properties of three different chemotypes of Lippia origanoides essential oil (EO) against susceptible and drug-resistant S. aureus strains. The chemical composition of the EO was analyzed using GC-MS, revealing high monoterpene concentrations, with carvacrol and thymol as the major components in two of the chemotypes. The third chemotype consisted mainly of the sesquiterpene β-caryophyllene. The MIC values for the two monoterpene chemotypes ranged from 62.5 to 500 µg/mL for all strains, whereas the sesquiterpene chemotype showed activity against seven strains at concentrations of 125–500 µg/mL, which is the first report of its anti-S. aureus activity. The phenolic chemotypes inhibited biofilm formation in seven S. aureus strains, whereas the sesquiterpene chemotype only inhibited biofilm formation in four strains. In addition, phenolic chemotypes displayed antihemolysis activity, with IC₅₀ values ranging from 58.9 ± 3.8 to 128.3 ± 9.2 µg/mL. Our study highlights the importance of L. origanoides EO from the Yucatan Peninsula, which has the potential for the development of anti-S. aureus agents. Full article

This study explores a nanoemulsion formulated with açaí seed oil, known for its rich fatty acid composition and diverse biological activities. This study aimed to characterise a nanoemulsion formulated with açaí seed oil and explore its cytotoxic effects on HeLa and SiHa cervical cancer cell lines, alongside assessing its antioxidant and toxicity properties both in vitro and in vivo. Extracted from fruits sourced in Brazil, the oil underwent thorough chemical characterization using gas chromatography–mass spectrometry. The resulting nanoemulsion was prepared and evaluated for stability, particle size, and antioxidant properties. The nanoemulsion exhibited translucency, fluidity, and stability post centrifugation and temperature tests, with a droplet size of 238.37, PDI -9.59, pH 7, and turbidity 0.267. In vitro assessments on cervical cancer cell lines revealed antitumour effects, including inhibition of cell proliferation, migration, and colony formation. Toxicity tests conducted in cell cultures and female Swiss mice demonstrated no adverse effects of both açaí seed oil and nanoemulsion. Overall, açaí seed oil, particularly when formulated into a nanoemulsion, presents potential for cancer treatment due to its bioactive properties and safety profile. Full article

Rat animal models are widely used owing to their relatively superior cognitive abilities and higher similarity compared with mouse models to human physiological characteristics. However, their use is limited because of difficulties in establishing embryonic stem cells and performing genetic modifications, and insufficient embryological research. In this study, we established optimal superovulation and fertilized–egg transfer conditions, including optimal hormone injection concentration (≥150 IU/kg of PMSG and hCG) and culture medium (mR1ECM), to obtain high-quality zygotes and establish in vitro fertilization conditions for rats. Next, sgRNA with optimal targeting activity was selected by performing PCR analysis and the T7E1 assay, and the CRISPR/Cas9 system was used to construct a rat model for muscular dystrophy by inducing a deficiency in the fukutin gene without any off-target effect detected. The production of fukutin knockout rats was phenotypically confirmed by observing a drop-in body weight to one-third of that of the control group. In summary, we succeeded in constructing the first muscular dystrophy disease rat model using the CRISPR/CAS9 system for increasing future prospects of producing various animal disease models and encouraging disease research using rats. Full article

Background: Breast cancer (BC) is frequently diagnosed among Canadian women. While targeted therapies are available for most BC patients; treatment resistance is common and novel therapeutic targets are of interest. Thyroid hormones (TH) bound to thyroid hormone receptors (THR) influence cell proliferation and differentiation; they are also involved in the growth and development of normal breast tissue. Evidence suggests that THRβ is a tumor suppressor in various solid tumors. Purpose: This narrative review discusses retrospective studies regarding the clinical relevance of THRβ as a potential prognostic biomarker and therapeutic target in BC. Methods: We consulted with an information specialist to develop a search strategy to find all literature related to THRα expression as a potential prognostic and therapeutic biomarker in breast cancer. The primary search was developed for Medline and translated to Embase. The searches were conducted on the Ovid platform on 18 August 2023. Results: Across seven retrospective studies identified, several have shown an association between higher THRβ1 expression with a lower risk of BC recurrence and with longer overall survival. Conclusions: Some evidence suggests that THRβ expression is associated with a lower risk of BC recurrence and death. Validation of THRβ as an independent prognostic biomarker and possible predictive biomarker of response to endocrine therapy and/or chemotherapy is of interest. Given that THRβ is upstream of the AKT/PI3K pathway, its potential as a predictive biomarker of response to AKT inhibitors and/or PI3K inhibitors may also be of value. Finally, the potential re-purposing of THRβ agonists as anti-cancer agents warrants investigation. Full article

Myelodysplastic neoplasm (MDS) is a heterogeneous group of clonal hematological disorders that originate from the hematopoietic and progenitor cells and present with cytopenias and morphologic dysplasia with a propensity to progress to bone marrow failure or acute myeloid leukemia (AML). Genetic evolution plays a critical role in the pathogenesis, progression, and clinical outcomes of MDS. This process involves the acquisition of genetic mutations in stem cells that confer a selective growth advantage, leading to clonal expansion and the eventual development of MDS. With the advent of next-generation sequencing (NGS) assays, an increasing number of molecular aberrations have been discovered in recent years. The knowledge of molecular events in MDS has led to an improved understanding of the disease process, including the evolution of the disease and prognosis, and has paved the way for targeted therapy. The 2022 World Health Organization (WHO) Classification and the International Consensus Classification (ICC) have incorporated the molecular signature into the classification system for MDS. In addition, specific germline mutations are associated with MDS development, especially in pediatrics and young adults. This article reviews the genetic abnormalities of MDS in adults with a brief review of germline predisposition syndromes. Full article

Many people experience intense fear of COVID-19. The purpose of this study was to provide a comprehensive visual overview of the published literature from 2020 to 2022 assessing fear of COVID-19. From 2020 to 2022, we employed the Scopus database to conduct a bibliometric analysis. We used the VOSviewer program to perform the author co-citation analysis, Mapchart to produce a worldwide map, and Wordart to make a word cloud image. From the 1769 records examined, 1654 (93.50%) were articles, with English being the most common language (96.31%). From 2020 to 2022, annual citations experienced significant growth (R² = 99.91%; p = 0.0195). The Institut National de la Santé et de la Recherche Médicale (INSERM, France) and China led in terms of publication output (n = 36; n = 255). M. D. Griffiths authored the highest number of articles (n = 21). The most active journal was the International Journal of Environmental Research and Public Health (n = 146), and the most prevalent keyword was “human/s” (11.51%). This bibliometric analysis evaluates the quality of the research on fear of the pandemic and the crisis management of COVID-19, which can provide managers and researchers with crucial insights for future decision making. Full article

Aim and Objectives: We aimed to test the predictive value of readily accessible and easily performed post-surgical “bedside tests” on their validity of long-term urinary incontinence (UI) (≥12 months) in patients following robot-assisted laparoscopic radical prostatectomy (RALP). Material and Methods: Patients undergoing RALP between July 2020 and March 2021 were prospectively included and subdivided into two groups based on their pad usage after 12 months (0 vs. ≥1 pad). After catheter removal, patients performed a 1 h pad test, documented the need for pad change in a micturition protocol and received post-voiding residual urine volume ultrasound. Univariate and multivariable analyses were used to demonstrate the predictive value of easily accessible tests applied after catheter removal for UI following RALP. Results: Of 109 patients, 47 (43%) had to use at least one pad (vs. 62 (57%) zero pads) after 12 months. Univariate testing showed a significant difference in urine loss between both groups evaluated by the 1 h pad test performed within 24 h after catheter removal (70% < 10 mL, vs. 30% ≥ 10 mL, p = 0.004) and in the need for pad change within the first 24 h after catheter removal (14% dry pads vs. 86% wet pads, p = 0.003). In multivariable analyses, the combination of both tests (synoptical incontinence score) could be confirmed as an independent predictor for UI after 12 months (p = 0.011). Conclusions: Readily accessible “everyday” diagnostics (pad test/change of pads after catheter removal) following RALP seem to be associated with a higher rate of long-term UI. This finding is crucial since patients with a potentially higher need for patient education and counselling can be identified using these readily accessible tests. This could lead to a higher patient satisfaction and improved outcomes. Full article

Despite a rhetorical turn towards prevention in homelessness policy and research, the work of youth homelessness prevention continues to be frustrated by persistent structural barriers. In this article, we examine how youth homelessness prevention is being implemented in the province of Ontario, with a focus on targeted provincial support programs and local shelter diversion practices. Drawing on interviews with workers in the homeless-serving sector, we describe the implementation of these initiatives and identify points of frustration and potential that workers encounter as they try to prevent experiences of homelessness for youth. We contend that these points of frustration illuminate persistent structural barriers that continue to forestall the work of youth homelessness prevention. Meanwhile, points of potential demonstrate the importance of empowering workers to creatively adapt and offer responsive services. Taken together, these signal the critical importance of two aspects of contemporary homelessness prevention typologies—primordial prevention and empowerment. We end by offering aspirations for action, a political reframing of the policy recommendations sections more typical of social science research articles. We do so to affirm our commitment to advancing the work of structural transformation that is required to achieve the right to housing for all, including youth. Full article

This study investigated the effect of compaction effort and soaking time on the shear strength properties of fine-grained gypsum-containing soils. The objective was to demonstrate that increasing compaction effort increases soil strength, specifically cohesion and the angle of shear strength, when subjected to soaking in freshwater. Unconsolidated undrained triaxial tests were carried out on CBR soil samples with different soaking times. The results showed a transition from brittle to ductile failure behaviour as the soaking time increased. Mohr–Coulomb failure envelopes showed reduced cohesion and angle of shear strength with increasing soak time. Regression models were developed to establish correlations between soaked and unsoaked strength parameters. Strong relationships were found between soil strength properties, compaction effort and soaking time. Empirical equations were proposed to estimate the cohesion and angle of shear strength from compaction effort and soaking time. This study highlighted the importance of considering gypsum-rich soils in civil engineering design. Gypsum dissolution during wetting significantly affected soil strength parameters. The regression models and empirical equations provide engineers with tools to assess the influence of compaction effort and soaking time on soil strength, thus aiding decision making when designing structures on gypsum-rich soils. Full article