Oxidative stress causes gut dysfunction and is a contributing factor in several intestinal disorders. Intestinal epithelial cell survival is essential for maintaining human and animal health under oxidative stress. 18beta-Glycyrrhetinic acid (GA) is known to have multiple beneficial effects, including antioxidant activity; however, the underlying molecular mechanisms have not been well established. Thus, the present study evaluated the therapeutic effects of GA on H₂O₂-induced oxidative stress in intestinal porcine epithelial cells. The results showed that pretreatment with GA (100 nM for 16 h) significantly increased the levels of several antioxidant enzymes and reduced corresponding intracellular levels of reactive oxidative species and malondialdehyde. GA inhibited cell apoptosis via activating the phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) signaling pathway, as confirmed by RNA sequencing. Further analyses demonstrated that GA upregulated the phosphorylation levels of PI3K and Akt and the protein level of B cell lymphoma 2, whereas it downregulated Cytochrome c and tumor suppressor protein p53 levels. Moreover, molecular docking analysis predicted the binding of GA to Vasoactive intestinal peptide receptor 1, a primary membrane receptor, to activate the PI3K/Akt signaling pathway. Collectively, these results revealed that GA protected against H₂O₂-induced oxidative damage and cell apoptosis via activating the PI3K/Akt signaling pathway, suggesting the potential therapeutic use of GA to alleviate oxidative stress in humans/animals. Full article

The main objective of this work is to evaluate the energy efficiency improvement obtained in grid-connected photovoltaic systems based on a dynamic reconfiguration strategy. The MIX and team reconfigurable photovoltaic system topologies have been considered since both minimize the operation of the inverters in low-load conditions. A numerical method is used to analyze the energy flows within the photovoltaic system, with a specific focus on the plant-oriented configuration. In this work, MIX systems are only presented briefly, while team reconfigurable photovoltaic systems are analyzed in more detail. This is because team systems can be implemented using conventional commercial inverters, electromechanical switches to redirect power flows, and a simple digital controller (as based on the Arduino platforms). The energy supplied to the grid by two grid-connected photovoltaic systems will be evaluated: one based on a classic non-reconfigurable strategy and another based on the team strategy. The measurement of the energy generated by these two systems, tested under various irradiance levels (emulating different climatic conditions), shows that reconfigurable systems always exhibit greater energy efficiency. However, this energy improvement can only be considered substantial in certain situations. Full article

Canada’s universities each receive an annual operating grant from their provincial government to partially finance operating expenses. This paper estimates the sensitivity of provincial operating grants to the business cycle by disentangling the effects of procyclical income on government revenue and the countercyclical effect on student demand by utilizing an economic regression model composed of three equations. Our panel data include the total real operating grant paid to all universities within a province, total student enrolment, real per capita government revenue, and real per capita gross domestic product for Canada’s ten provinces over the 1992–2019 sample period. The results confirm that real per capita government revenues are procyclical and that full-time equivalent student enrolments are counter-cyclical. The total real operating grant is only weakly associated with cyclical changes in provincial government revenue. Instead, the total real operating grant is mainly determined by countercyclical changes in student demand. This partially offsets the potential reduction in funding to universities during an economic downturn. Provincial governments in Canada can smooth the total allocation over the business cycle by adjusting other expenditures and using debt financing. Our results suggest they do this to some extent, but not enough to avoid a net reduction in real operating grants during an economic downturn. Full article

[¹⁷⁷Lu]Lu-PSMA-617 has recently been successfully approved by the FDA, the MHRA, Health Canada and the EMA as Pluvicto^®. However, salivary gland (SG) and kidney toxicities account for its main dose-limiting side-effects, while its corresponding uptake and retention mechanisms still remain elusive. Recently, the presence of different ATP-binding cassette (ABC) transporters, such as human breast cancer resistance proteins (BCRP), multidrug resistance proteins (MDR1), multidrug-resistance-related proteins (MRP1, MRP4) and solute cassette (SLC) transporters, such as multidrug and toxin extrusion proteins (MATE1, MATE2-K), organic anion transporters (OAT1, OAT2v1, OAT3, OAT4) and peptide transporters (PEPT2), has been verified at different abundances in human SGs and kidneys. Therefore, our aim was to assess whether [¹⁷⁷Lu]Lu-PSMA-617 and [²²⁵Ac]Ac-PSMA-617 are substrates of these ABC and SLC transporters. For in vitro studies, the novel isotopologue ([α,β-³H]Nal)Lu-PSMA-617 was used in cell lines or vesicles expressing the aforementioned human ABC and SLC transporters for inhibition and uptake studies, respectively. The corresponding probe substrates and reference inhibitors were used as controls. Our results indicate that [¹⁷⁷Lu]Lu-PSMA-617 and [²²⁵Ac]Ac-PSMA-617 are neither inhibitors nor substrates of the examined transporters. Therefore, our results show that human ABC and SLC transporters play no central role in the uptake and retention of [¹⁷⁷Lu]Lu-PSMA-617 and [²²⁵Ac]Ac-PSMA-617 in the SGs and kidneys nor in the observed toxicities. Full article

Antimicrobial resistance is a silent pandemic harming human health, and Pseudomonas aeruginosa is the most common bacterium responsible for chronic pulmonary and eye infections. Antimicrobial peptides (AMPs) represent promising alternatives to conventional antibiotics. In this review, the in vitro/in vivo activities of the frog skin-derived AMP Esc(1-21) are shown. Esc(1-21) rapidly kills both the planktonic and sessile forms of P. aeruginosa and stimulates migration of epithelial cells, likely favoring repair of damaged tissue. However, to undertake preclinical studies, some drawbacks of AMPs (cytotoxicity, poor biostability, and limited delivery to the target site) must be overcome. For this purpose, the stereochemistry of two amino acids of Esc(1-21) was changed to obtain the diastereomer Esc(1-21)-1c, which is more stable, less cytotoxic, and more efficient in treating P. aeruginosa-induced lung and cornea infections in mouse models. Incorporation of these peptides (Esc peptides) into nanoparticles or immobilization to a medical device (contact lens) was revealed to be an effective strategy to ameliorate and/or to prolong the peptides’ antimicrobial efficacy. Overall, these data make Esc peptides encouraging candidates for novel multifunctional drugs to treat lung pathology especially in patients with cystic fibrosis and eye dysfunctions, characterized by both tissue injury and bacterial infection. Full article

Unique worldwide, nitrate/iodine deposits (NIDs) are located along a 700 km geological belt in the Atacama Desert, Chile. They serve as the primary source of mineral ores for the extraction of iodine, sodium, and potassium nitrates. NIDs have been relatively underexplored from a biological perspective. To address this, we collected sixteen soil samples from abandoned mines in Oficinas Pissis and Savona for chemical, mineralogical, and metagenomic analyses. The soils primarily consisted of halite and darapskite, with only one sample being predominantly composed of thenardite. Deliquescence and water activity measurements yielded values ranging from 0.02% to 0.40% and 0.47 to 0.62, respectively. To investigate the presence, identification, relative abundance, and diversity of microbial life in NID soils, we employed MiSeq high-throughput sequencing and bioinformatic tools. The dominant phyla observed were Firmicutes and Proteobacteria, with Actinobacteria and Cyanobacteria being predominant in two soil samples. Furthermore, we detected nitrate/perchlorate-reducing bacterial activity in enriched cultures from the soil samples. This study sheds light on the resilience of microbial life in the Atacama Desert NIDs, providing compelling evidence for its existence and offering insight into factors that could facilitate it within this unique environment. Full article

Background and Objectives: Drug resistant epilepsy (DRE) is a major hurdle in epilepsy, which hinders clinical care, patients’ management and treatment outcomes. DRE may partially result from genetic variants that alter proteins responsible for drug targets and drug transporters in the brain. We aimed to examine the relationship between SCN1A, GABRA1 and ABCB1 polymorphism and drug response in epilepsy children in Vietnam. Materials and Methods: In total, 213 children diagnosed with epilepsy were recruited in this study (101 were drug responsive and 112 were drug resistant). Sanger sequencing had been performed in order to detect six single nucleotide polymorphisms (SNPs) belonging to SCN1A (rs2298771, rs3812718, rs10188577), GABRA1 (rs2279020) and ABCB1 (rs1128503, rs1045642) in study group. The link between SNPs and drug response status was examined by the Chi-squared test or the Fisher’s exact test. Results: Among six investigated SNPs, two SNPs showed significant difference between the responsive and the resistant group. Among those, heterozygous genotype of SCN1A rs2298771 (AG) were at higher frequency in the resistant patients compared with responsive patients, playing as risk factor of refractory epilepsy. Conversely, the heterozygous genotype of SCN1A rs3812718 (CT) was significantly lower in the resistant compared with the responsive group. No significant association was found between the remaining four SNPs and drug response. Conclusions: Our study demonstrated a significant association between the SCN1A genetic polymorphism which increased risk of drug-resistant epilepsy in Vietnamese epileptic children. This important finding further supports the underlying molecular mechanisms of SCN1A genetic variants in the pathogenesis of drug-resistant epilepsy in children. Full article

Wildfire is one of the most severe natural disasters globally, profoundly affecting natural ecology, economy, and health and safety. Precisely predicting the spread of wildfires has become an important research topic. Current fire spread prediction models depend on inputs from a variety of geographical and environmental variables. However, unlike the ideal conditions simulated in the laboratory, data gaps often occur in real wildfire scenarios, posing challenges to the accuracy and robustness of predictions. It is necessary to explore the extent to which different missing items affect prediction accuracy, thereby providing rational suggestions for emergency decision-making. In this paper, we tested how different conditions of missing data affect the prediction accuracy of existing wildfire spread models and quantified the corresponding errors. The final experimental results suggest that it is necessary to judge the potential impact of data gaps based on the geographical conditions of the study area appropriately, as there is no significant pattern of behavior yet identified. This study aims to simulate the impact of data scarcity on the accuracy of wildfire spread prediction models in real scenarios, thereby enabling researchers to better understand the priority of different environmental variables for the model and identify the acceptable degree of missing data and the indispensable data attributes. It offers new insights for developing spread prediction models applicable to real-world scenarios and rational assessment of the effectiveness of model outcomes. Full article

This paper applies fractional calculus to a practical example in fluid mechanics, illustrating its impact beyond traditional integer order calculus. We focus on the classic problem of a rigid body rotating within a uniformly rotating container, which generates a liquid vortex from an undisturbed initial state. Our aim is to compare the time evolutions of the physical system in fractional and integer order models by examining the torque transmission from the rotating body to the surrounding liquid. This is achieved through closed-form, time-developing solutions expressed in terms of Mittag–Leffler and Bessel functions. Analysis reveals that the rotational velocity and, consequently, the vortex structure of the liquid are influenced by three distinct time zones that differ between integer and noninteger models. Anomalous diffusion, favoring noninteger fractions, dominates at early times but gradually gives way to the integer derivative model behavior as time progresses through a transitional regime. Our derived vortex formula clearly demonstrates how the liquid vortex is regulated in time for each considered fractional model. Full article

To estimate the possibility of using both low-melting TecaPEI and neat PEI films as energy directors (EDs) for ultrasonic welding (USW) of carbon fiber (CF) fabric–polyetherimide (PEI) laminates, some patterns of structure formation and mechanical properties of their lap joints were investigated by varying the process parameters. The experiment was planned by the Taguchi method with the L9 orthogonal matrix. Based on the obtained results, USW parameters were optimized accounting for maintaining the structural integrity of the joined components and improving their functional characteristics. The use of the low-melting ED_TecaPEI film enabled US-welding the laminates with minimal damage to the fusion zone, and the achieved lap shear strength (LSS) values of ~7.6 MPa were low. The use of ED_SolverPEI excluded thermal degradation of the components as well as damage to the fusion zone, and improved LSS values to 21 MPa. With the use of digital image correlation (DIC) and computed tomography (CT) techniques, the structural factors affecting the deformation behavior of the USW lap joints were justified. A scheme was proposed that established the relationship between structural factors and the deformation response of the USW lap joints under static tension. The TecaPEI film can be used in USW procedures when very high interlayer adhesion properties are not on demand. Full article

The characteristics of iron minerals in cyanidation tailings with a low iron grade were determined via chemical composition analysis, iron phase analysis, and mineral liberation analysis (MLA). The results showed that the cyanidation tailings contained 15.68% iron, mainly occurring in the form of magnetite (19.66%) and limonite (79.91%), in which 16.52% magnetite and 65.90% limonite particles were fully liberated. Most ultra-fine magnetite grains were adjacent and wrapped with limonite to form complex intergrowths, which resulted in low-efficiency magnetite recovery in low-intensity magnetic separation (LIMS) and adversely affected the downstream high-gradient magnetic separation (HGMS) process. Thus, in this work, the optimization of the flow field was proposed to enhance the separation of ultra-fine magnetite from the cyanidation tailings using pilot-scale LIMS separation, and the controllable parameters (including feed flow, separation gap, drum rotating speed, and solid weight) affecting ultra-fine magnetite capture were investigated. Under optimized conditions, a high-grade magnetite concentrate assaying 63.31% Fe with 86.46% magnetite recovery was produced, which, respectively, increased by 0.76% and 15.22%, compared with those obtained from industrial production. In addition, from the flow dynamics simulation, it was found that the magnetite particles in the −6 µm ultra-fine fraction were lost much more easily than those of coarser fractions due to the relatively enhanced hydrodynamic drag force acting on the particles compared with the magnetic force. However, this loss would be effectively reduced with the regulation and control of the flow field. The iron recoveries in the −16~+6 µm and −6 µm fractions of magnetite concentrate increased by 3.66% and 4.42%, respectively, under optimized hydrodynamic conditions. This research outcome provides a valuable reference for the economic and effective utilization of iron resources from such solid wastes. Full article

Glutathione transferases (GSTs EC 2.5.1.18) are critical components of phase II metabolism, instrumental in xenobiotics’ metabolism. Their primary function involves conjugating glutathione to both endogenous and exogenous toxic compounds, which increases their solubility and enables their ejection from cells. They also play a role in the transport of non-substrate compounds and immunomodulation, aiding in parasite establishment within its host. The cytosolic GST subfamily is the most abundant and diverse in helminths, and sigma-class GST (GSTσ) belongs to it. This review focuses on three key functions of GSTσ: serving as a detoxifying agent that provides drug resistance, functioning as an immune system modulator through its involvement in prostaglandins synthesis, and acting as a vaccine antigen. Full article

The sustainable urban design of residential neighborhoods plays an important role in the efforts to achieve the sustainable development goals and alleviate the effects of climate change. This paper aims to develop a model for the sustainable urban design of residential neighborhoods, taking into account the local condition in Palestinian territories. This model is built on various international neighborhood sustainability assessment (NSA) tools, based on the review of existing assessment tools, to study the sustainability status of Palestinian neighborhoods, and to develop a sustainable indicator model for local sustainable neighborhood assessment. Computer tools like Urbano and GIS tools as well as qualitative assessment methods are used. Results from the case study showed that the satisfaction of the preferred location indicator was not sufficient to maintain its sustainability. The assessment of measured indicators found that weaknesses were almost double the count of the satisfactory indicator. Moreover, some indicators from the (NSA) tools were partially or completely met, and some gaps appeared because of the lack of strengths in the selected indicators of the international tools when used for local social, ecological and governmental aspects, and there are issues in the inclusion of economic and environmental elements in current urban configurations. The proposed local model offers valuable insights for local governments, municipalities, and construction developers. Full article

This paper delves into integrating technological and social innovations in design through a community-oriented, resilient approach, emphasizing care and sustainability. It explores resource management’s application to the local environment and education, focusing on adaptable spaces, active collaboration, and innovative solutions for environmental and social challenges. Developed within the EU Marie Curie-funded TREnD project, it combines ‘transition’ and ‘resilience-building’ processes, framing co-creation solutions and tailored innovation policies. The research group conducted theoretical and empirical research in the EU and USA, introducing a place-sensitive approach in managing transition through technological diversification. A case study in Ruston (LA, USA), Camp Alabama, exemplifies inclusive design through circular design and low-tech construction, creating adaptable pavilions for the community. Collaborating with MedCamps of Louisiana, the project designs a shared and inclusive space within budget constraints, emphasizing the pivotal role of architecture in advancing community well-being. Employing a bottom-up approach, the practice engages users, students, teachers, and local stakeholders in co-design, resulting in a people-based citadel of care. Outcomes feature high-design technological projects produced through a “low-tech” approach, allowing adaptability in urban regeneration. The 2023 project received awards, showcasing progress and the potential for replication through standardized methodology. Additional outcomes include educational benefits, training architects for societal needs, and regenerating urban areas by exploiting local resources. Full article

The effects of social (eye gaze, pointing gestures) and symbolic (arrows) cues on observers’ attention are often studied by presenting such cues in isolation and at fixation. Here, we extend this work by embedding cues in natural scenes. Participants were presented with a single cue (Experiment 1) or a combination of cues (Experiment 2) embedded in natural scenes and were asked to ‘simply look at the images’ while their eye movements were recorded to assess the effects of the cues on (overt) attention. Single-gaze and pointing cues were fixated for longer than arrows but at the cost of shorter dwell times on the cued object. When presented together, gaze and pointing cues were fixated faster and for longer than simultaneously presented arrows. Attention to the cued object depended on the combination of cues and whether both cues were directed towards or away from the target object. Together, the findings confirm earlier observations that people attract attention more strongly than arrows but that arrows more strongly direct attention. Full article

The current understanding of clinical approaches and barriers in managing childhood myopia among Indian optometrists is limited. This research underscores the necessity and relevance of evidence-based practice guidelines by exploring their knowledge, attitude, and practice towards childhood myopia. A self-administered internet-based 26-item survey was circulated online among practicing optometrists in India. The questions assessed the demographics, knowledge, self-reported clinical practice behavior, barriers, source of information guiding their management, and extent of adult caregiver engagement for childhood myopia. Of 393 responses, a significant proportion of respondents (32.6–92.4%) were unaware of the ocular complications associated with high myopia, with less than half (46.5%) routinely performing ocular biometry in clinical practice. Despite the growing awareness of emerging myopia management options, the uptake remains generally poor, with single-vision distance full-correction spectacles (70.3%) being the most common mode of vision correction. Barriers to adopting optimal myopia care are medicolegal concerns, absence of clinical practice guidelines, and inadequate consultation time. Own clinical experience and original research articles were the primary sources of information supporting clinical practice. Most (>70%) respondents considered involving the adult caregiver in their child’s clinical decision-making process. While practitioners’ awareness and activity of newer myopia management strategies are improving, there is plenty of scope for its enhancement. The importance of evidence-based practice guidelines and continuing education on myopia control might help practitioners enhance their clinical decision-making skills. Full article

The aim of this paper is to conduct a literature review of the existing nexus between conspiracy theories and populist politics. Most of the literature considering the political nature of conspiracy theories has focused mainly on individual action and electoral choices, hence setting aside the agency of political leaders that deliberately resort to these tales to mobilise supporters. On the contrary, conspiracy theories are increasingly moving away from extremist politics to enter the institutional political arena and become part and parcel of the political narratives and strategies of institutional figures. Against this backdrop, the present work offers a new approach to investigate the connection between populist conspiracy theories and conspiracist populism and attempts to explain how conspiracist populism works and what its potential impact on contemporary democracies is. The analysis of the literature offers some theoretical insights to explore the specific case of the presidency of Kais Saied in Tunisia, which has been labelled as a form of constitutional populism integrating conspiracy theories. The inquiry on the Tunisian case demonstrates that conspiracy theories can represent both tactics and framings for populists in power, and, if democratic checks and balances are weak enough, they can lead to the erosion of democracy itself. Full article

The manipulation of droplets plays a vital role in biomedicine, chemistry, and hydromechanics, especially in microfluidics. Magnetic droplet manipulation has emerged as a prominent and advanced technique in comparison to other modes such as dielectric infiltration, optical radiation, and surface acoustic waves. Its notable progress is attributed to several advantages, including excellent biocompatibility, remote and non-contact control, and instantaneous response. This review provides a comprehensive overview of recent developments in magnetic droplet manipulation and its applications within the biomedical field. Firstly, the discussion involves an examination of the distinctive features associated with droplet manipulation based on both permanent magnet and electromagnet principles, along with a thorough exploration of the influencing factors impacting magnetic droplet manipulation. Additionally, an in-depth review of magnetic actuation mechanisms and various droplet manipulation methods is presented. Furthermore, the article elucidates the biomedical applications of magnetic droplet manipulation, particularly its role in diagnostic assays, drug discovery, and cell culture. Finally, the highlights and challenges of magnetic droplet manipulation in biomedical applications are described in detail. Full article

Walnut trees are grown worldwide for their edible fruits, which have high nutritional value. To address climate change, researchers have studied walnut phenology to create cultivars adapted to warmer climates. The objective of this study is to propose a scale for phenological Persian walnut observations using the Biologische Bundesanstalt, Bundessortenamt, und CHemische Industrie (BBCH) codification and alignment with historical alphameric scales. Here, the principal growth stages (PGSs) of Persian walnut (Juglans regia L.) are described using stages from a previously available alphanumeric scale. This standardised phenological scale describes Persian walnut growth from the dormant vegetative state through reproductive budding and senescence. This phenological scale is expected to increase the efficiency of walnut phenological monitoring. Fifty-seven stages are used to describe the life cycle of Persian walnut in this BBCH scale. Of these 57 stages, 3 stages are dedicated to seed germination (PGS-0), 4 stages are dedicated to bud development (PGS-0), 7 stages are dedicated to leaf development (PGS-1), 4 stages are dedicated to stem elongation (PGS-3), 8 stages are dedicated to inflorescence emergence (PGS-5), 5 stages are dedicated to male flowering (PGS-6), 5 stages are dedicated to female flowering (PGS-6), 5 stages are dedicated to fruit development (PGS-7), 12 stages are dedicated to fruit ripening (PGS-8), and 4 stages are dedicated to leaf senescence (PGS-9). Full article

Modern integrated circuits (ICs) take advantage of three-dimensional (3D) nanostructures in devices and interconnects to achieve high-speed and ultra-low-power performance. The choice of electrical insulation materials with excellent dielectric strength, electrical resistivity, strong mechanical strength, and high thermal conductivity becomes critical. Diamond possesses these properties and is recently recognized as a promising dielectric material for the fabrication of advanced ICs, which are sensitive to detrimental high-temperature processes. Therefore, a high-rate low-temperature deposition technique for large-grain, high-quality diamond films of the thickness of a few tens to a few hundred nanometers is desirable. The diamond growth rate by microwave plasma chemical vapor deposition (MPCVD) decreases rapidly with lowering substrate temperature. In addition, the thermal conductivity of non-diamond carbon is much lower than that of diamond. Furthermore, a small-grain diamond film suffers from poor thermal conductivity due to frequent phonon scattering at grain boundaries. This paper reports a novel MPCVD process aiming at high growth rate, large grain size, and high sp³/sp² ratio for diamond films deposited on silicon. Graphite paste containing nanoscale graphite and oxy-hydrocarbon binder and solvent vaporizes and mixes with gas feeds of hydrogen, methane, and carbon dioxide to form plasma. Rapid diamond growth of diamond seeds at 450 °C by the plasma results in large-grained diamond films on silicon at a high deposition rate of 200 nm/h. Full article

The pressing demand for novel compounds to address contemporary health challenges has prompted researchers to venture into uncharted territory, including extreme ecosystems, in search of new natural pharmaceuticals. Fungi capable of tolerating extreme conditions, known as extremophilic fungi, have garnered attention for their ability to produce unique secondary metabolites crucial for defense and communication, some of which exhibit promising clinical significance. Among these, halophilic fungi thriving in high-salinity environments have particularly piqued interest for their production of bioactive molecules. This review highlights the recent discoveries regarding novel compounds from halotolerant fungal strains isolated from various saline habitats. From diverse fungal species including Aspergillus, Penicillium, Alternaria, Myrothecium, and Cladosporium, a plethora of intriguing molecules have been elucidated, showcasing diverse chemical structures and bioactivity. These compounds exhibit cytotoxicity against cancer cell lines such as A549, HL60, and K-562, antimicrobial activity against pathogens like Escherichia coli, Bacillus subtilis, and Candida albicans, as well as radical-scavenging properties. Notable examples include variecolorins, sclerotides, alternarosides, and chrysogesides, among others. Additionally, several compounds display unique structural motifs, such as spiro-anthronopyranoid diketopiperazines and pentacyclic triterpenoids. The results emphasize the significant promise of halotolerant fungi in providing bioactive compounds for pharmaceutical, agricultural, and biotechnological uses. However, despite their potential, halophilic fungi are still largely unexplored as sources of valuable compounds. Full article

We investigate the potential of global real estate to improve the long-term performance of a US equity portfolio, utilizing a recent dataset of 40 years’ worth of US stocks, US real estate, 13 foreign stock markets, and 13 foreign real estate markets across diverse regions. Despite a modest performance in terms of risk and return, foreign real estate has consistently lower correlations with US stocks compared to foreign equities. Rolling correlation analysis indicates that foreign real estate markets remain relatively segmented compared to foreign equity, despite increasing financial market correlations over time. Efficient frontier analysis demonstrates that portfolios including foreign real estate consistently outperform those limited to US stocks and US real estate or those including foreign stocks, indicating the importance of foreign real estate in optimizing portfolio performance. Subperiod analysis reveals that foreign real estate retains its diversification benefits even in the latter, more integrated period. Our results are robust when using Conditional Value-at-Risk as a measure of risk. Overall, our findings highlight the persistent diversification benefits and superior risk-adjusted returns from incorporating foreign real estate into US equity portfolios. Full article