Facility agriculture is an important initiative to adopt an all-encompassing approach to food and build a diversified food supply system. Understanding the evolution of facility agricultural land and the factors that drive it can contribute to the development of scientifically strategic agricultural planning and agricultural modernization. Therefore, this paper constructs a “situation-structure-behavior-value” theoretical framework; quantifies the relevant driving factors (physical, proximal, and socioeconomic) and their impacts on the development and layout of facility agriculture land by using a multivariate logistic regression model; and provides a strategy for optimizing land use. The results showed that the area of facility agriculture in Huzhou is rapidly expanding. Regarding drivers, facility agricultural land tends to be located in areas with higher slopes according to plot selection. Facility agriculture is more likely to develop in plots with convenient transportation and closer proximity to markets. At the economic level, economic efficiency, agricultural resource superiority, and policies significantly impact facility agriculture expansion. Finally, we propose three land use policy options to facilitate the sustainable development of facility agriculture. This study elucidates the underlying factors driving different types of facility agricultural land and offers methodological guidance for policy support, planning, control, and optimization strategies for facility agriculture. Full article

Background: Traumatic spinal injury in children is a rare but serious life event. Predicting pediatric patients at risk for spinal injury remains difficult. This study focuses on the cause of the injury and predictors to identify children at risk and appropriate diagnostic procedures. Methods: Retrospective chart review from the Landelijke Trauma Registratie of patients with spinal injury from 2010 to 2021 in a level 1 pediatric trauma center. Results: We included 114 children with spinal injury, 79.8% of whom were aged 12–17 years. In the overall trauma population, the incidence of spinal injury was 10% in children aged 12–17 years, 2.3% in children aged 6–11 years, and 0.4% in children 0–5 years of age. Neurological deficits were present in 27.2% of patients in the emergency department, with permanent deficits in 14.0%. Spinal fractures were present in 91.2% of 12–17-year-olds, 43.8% in 6–11-year-olds, and 71.4% in 0–5-year-olds. ISS was 23 (SD 14) in children with spinal injury compared to 8 (SD 9) for children without spinal injury. Conclusions: In children 0–11 years old, spinal injury is very rare compared to the overall trauma population, and there are more non-osseous injuries. Clinicians should consider MRI as the next step after conventional X-ray to diagnose or exclude spinal injuries in this group. In older children aged 12–17 years, the incidence of spinal injury is much higher, at 10%. Although ISS is higher in children with spinal injury, a low ISS does not exclude spinal injury. If one fracture is found, more fractures in other regions of the spine may be present. Full article

The efficacy of retainers is a pivotal concern in orthodontic care. This study examined the biomechanical behaviour of retainers, particularly the influence of retainer stiffness and tooth resilience on force transmission and stress distribution. To do this, a finite element model was created of the lower jaw from the left to the right canine with a retainer attached on the oral side. Three levels of tooth resilience and variable retainer bending stiffness (influenced by retainer type, retainer diameter, and retainer material) were simulated. Applying axial or oblique (45° tilt) loads on a central incisor, the force transmission increased from 2% to 65% with increasing tooth resilience and retainer stiffness. Additionally, a smaller retainer diameter reduced the uniformity of the stress distribution in the bonding interfaces, causing concentrated stress peaks within a small field of the bonding area. An increase in retainer stiffness and in tooth resilience as well as a more oblique load direction all lead to higher overall stress in the adhesive bonding area associated with a higher risk of retainer bonding failure. Therefore, it might be recommended to avoid the use of retainers that are excessively stiff, especially in cases with high tooth resilience. Full article

Background: Minimally invasive surgery in the treatment of colon cancer has significantly advanced over the years. This systematic review and meta-analysis aimed to compare the operative outcomes of robotic and laparoscopic surgery in the treatment of colon cancer, focusing on operative time, hospital stay, conversion rates, anastomotic leak rates, and total number lymph node harvested. Methods: Following PRISMA guidelines, we conducted a systematic search across four databases up to January 2024, registering our protocol with PROSPERO (CRD42024513326). We included studies comparing robotic and laparoscopic surgeries for colon cancer, assessing operative time, hospital length of stay, and other perioperative outcomes. Risk of bias was evaluated using the JBI Critical Appraisal Checklist. Statistical analysis utilized a mix of fixed and random-effects models based on heterogeneity. Results: A total of 21 studies met the inclusion criteria, encompassing 50,771 patients, with 21.75% undergoing robotic surgery and 78.25% laparoscopic surgery. Robotic surgery was associated with longer operative times (SMD = −1.27, p < 0.00001) but shorter hospital stays (MD = 0.42, p = 0.003) compared to laparoscopic surgery. Conversion rates were significantly higher in laparoscopic procedures (OR = 2.02, p < 0.00001). No significant differences were found in anastomotic leak rates. A higher number of lymph nodes was harvested by robotic approach (MD = −0.65, p = 0.04). Publication bias was addressed through funnel plot analysis and Egger’s test, indicating the presence of asymmetry (p = 0.006). Conclusions: The choice of surgical method should be individualized, considering factors such as surgeon expertise, medical facilities, and patient-specific considerations. Future research should aim to elucidate long-term outcomes to further guide the clinical decision-making. Full article

The photocatalytic removal of nitric oxide (NO) is a promising technology used to reduce the level of harmful gaseous pollutants in parts per billion (ppb). As a potential photocatalyst, Bi₂Sn₂O₇ has a low quantum efficiency due to its fast recombination rate of photo-generated carriers. In this paper, Bi/Bi₂Sn₂O₇ was prepared by the in situ deposition of Bi. The structural, electrical, and optical properties of the attained sample were investigated through a series of analyses. The results demonstrate that Bi nanoparticles not only enhance the photoabsorption ability of Bi₂Sn₂O₇ due to their surface plasmon resonance (SPR) effect, but also improve its photocatalytic activity. Photocatalytic performance was evaluated by the oxidation of NO at ppb level under xenon lamp (λ > 400 nm) irradiation. It was found that the photocatalytic NO removal rate increased from 7.2% (Bi₂Sn₂O₇) to 38.6% (Bi/Bi₂Sn₂O₇). The loading of Bi promotes the separation and migration of photo-generated carriers and enhances the generation of • O²⁻ and • OH radicals responsible for the oxidation of NO. The Bi/Bi₂Sn₂O₇ composite photocatalyst also exhibits excellent photocatalytic stability, which makes it a potential candidate for use in air purification systems. Full article

This paper presents a comprehensive approach to forecasting hydro–meteorological changes in a marine area, i.e., in large bodies of water, from open water to coastal zones. First, hydro–meteorological factors, their interactions, and their implications for marine ecosystems are described. In addition, an analysis is outlined specifically for the Baltic Sea area. Next, the procedure for forecasting expected changes in major hydro–meteorological parameters in the sea is presented and a series of steps is accurately described. An extensive prognosis is provided for the southern Baltic Sea region using historical data obtained from the Polish National Institute of Water Management and Meteorology. The procedure is applied for seven measurement points which were assigned to four sub-areas for examining trends in wind regimes and wave height patterns using the authors’ own written software and statistical methods for data analysis. The model was validated within the southern Baltic Sea region. This paper also highlights the significance of forecasting for human beings, the environment, and critical infrastructure by proposing adaptive strategies and integrated coastal zone management in mitigating risks and enhancing resilience. Finally, future directions for research are proposed. Full article

The use of antibiotics to promote growth and prevent diarrhea in livestock production has raised concerns about the emergence of antibiotic-resistant bacteria. Probiotics, live microorganisms that confer health benefits, have been proposed as alternatives to antibiotics. In this study, we produced and characterized a downgraded maple syrup-based feed supplement containing Bacillus velezensis FZB42 as a potential synbiotic for animal nutrition. An optimized fermentation medium was developed through a central composite design to produce B. velezensis FZB42 at both the laboratory and pilot scale, reaching a concentration of 6.15 ± 0.46 × 10⁹ CFU/mL. Subsequently, B. velezensis FZB42 was incorporated into a protective whey permeate matrix and spray-dried, resulting in a 31.4% yield with a moisture content of 4.38%. The survival of B. velezensis FZB42 in a simulated gastrointestinal tract was evaluated using the TIM-1 system, revealing a survival rate of 16.05% after passage through the gastric, duodenal, jejunal, and ileal compartments. These findings highlight the possibility of B. velezensis FZB42 being an economically viable and possibly functional synbiotic supplement and effective alternative to antibiotic growth promoters in livestock production. Full article

The intensive use of air conditioning systems, primarily refrigerating, to promote thermal comfort in countries such as Brazil (a hot climate country) is changing the electrical energy consumption patterns and peak demand. Even with the increased number of appliances, we must learn to consume less energy to achieve similar outcomes with higher energy efficiency. Consequently, exergy analysis is used to evaluate the quality of these energy conversion systems. Four computational human thermal models were used to assess thermal comfort conditions: one man wearing lighter clothing, one man wearing traditional office clothing, and two women in the two types of clothing. We chose these four models since the body composition and basal metabolism rates for males and females differ. In addition, the insulation of clothes influences the temperature of the thermal environment, leading to a significantly lower percentage of people being unsatisfied, from 12.8% to values close to 5%. The outputs of these occupants are used as inputs for a computational model of the room to calculate its associated thermal loads and evaluate different temperature setpoints and their effects on thermal comfort and energy consumption. Results indicate that environmental temperatures above 24 ${}^{\circ }$C and below 26 ${}^{\circ }$C may lead to thermal comfort conditions, depending on the occupants’ clothing. Clothing would represent a thermal resistance of 0.7 CLO for men and women (when in the luteal phase of the menstrual cycle) and 0.8 CLO for women in the follicular phase when the environment is at 25 ${}^{\circ }$C. Therefore, there is a significant reduction in the compression power of the central cooling system by about 2.2% compared to 24 ${}^{\circ }$C and around 8% compared to ambient temperatures around 21 ${}^{\circ }$C. Full article

The majority of cases of undifferentiated acute febrile illness (AFI) in the tropics have an undefined etiology. In Thailand, AFI accounts for two-thirds of illnesses reported to the Ministry of Public Health. To characterize the bacterial and viral causes of these AFIs, we conducted molecular pathogen screening and serological analyses in patients who sought treatment in Chum Phae Hospital, Khon Kaen province, during the period from 2015 to 2016. Through integrated approaches, we successfully identified the etiology in 25.5% of cases, with dengue virus infection being the most common cause, noted in 17% of the study population, followed by scrub typhus in 3.8% and rickettsioses in 6.8%. Further investigations targeting viruses in patients revealed the presence of Guadeloupe mosquito virus (GMV) in four patients without other pathogen co-infections. The characterization of four complete genome sequences of GMV amplified from AFI patients showed a 93–97% nucleotide sequence identity with GMV previously reported in mosquitoes. Nucleotide substitutions resulted in amino acid differences between GMV amplified from AFI patients and mosquitoes, observed in 37 positions. However, these changes had undergone purifying selection pressure and potentially had a minimal impact on protein function. Our study suggests that the GMV strains identified in the AFI patients are relatively similar to those previously reported in mosquitoes, highlighting their potential role associated with febrile illness. Full article

There is growing recognition of early-onset gastrointestinal (GI) malignancies in young adults < 50 years of age. While much of the literature has emphasized colorectal cancer, these also include esophageal, gastric, liver, pancreatic, and biliary tract malignancies. Various factors, including lifestyle, hereditary, and environmental elements, have been proposed to explain the rising incidence of GI malignancies in the younger population. This review aims to provide an overview of the recent literature, including global trends and information regarding genetic and environmental risk factors. Full article

The advancement of both porous materials and nanomaterials has brought about porous nanomaterials. These new materials present advantages both due to their porosity and nano-size: small size apt for micro/nano device integration or in vivo transport, large surface area for guest/target molecule adsorption and interaction, porous channels providing accessibility to active/surface sites, and exposed reactive surface/active sites induced by uncoordinated bonds. These properties prove useful for the development of different porous composition types (metal oxides, silica, zeolites, amorphous oxides, nanoarrays, precious metals, non-precious metals, MOFs, carbon nanostructures, MXenes, and others) through different synthetic procedures—templating, colloidal synthesis, hydrothermal approach, sol-gel route, self-assembly, dealloying, galvanostatic replacement, and so—for different applications, such as catalysis (water-splitting, etc.), biosensing, energy storage (batteries, supercapacitors), actuators, SERS, and bio applications. Here, these are presented according to different material types showing the evolution of the structure design and development towards the formation of hierarchical porous structures, emphasizing that the formation of porous nanostructures came about out of the desire and need to form hierarchical porous nanostructures. Common trends observed across these different composition types include similar (aforementioned) applications and the use of porous nanomaterials as templates/precursors to create novel ones. Towards the end, a discussion on the link between technological advancements and the development of porous nanomaterials paves the way to present future perspectives on these nanomaterials and their hierarchical porous architectures. Together with a summary, these are given in the conclusion. Full article

Due to inadequate resource availability and environmental contamination, the Chinese government has placed a high priority on ecological civilization in recent years. Emphasis has been placed on the environmentally friendly conversion of the economy and the sustainable progress of society. China has established a fiscal decentralization system that divides financial responsibilities between the central and local governments. Due to their proximity advantage, local governments, as agents of the central government, can effectively deliver public services, optimize resource allocation, encourage innovation in green science and technology, and facilitate green growth in the region. However, local governments may exhibit myopic behaviors that impede the sustainable development of the region in their pursuit of regional growth ambitions. Therefore, this paper aims to investigate whether the institutional factor of fiscal decentralization promotes or inhibits the efficiency of green development in China. Using data from Chinese prefecture-level cities between 2010 and 2020, this paper presents the SBM-DDF model to measure the green growth efficiency ($GGE$) in cities. The study then analyzes the spatial impact of fiscal decentralization on $GGE$ using a dynamic panel model and a dynamic SAR model. The empirical results show that China’s green development level has steadily increased in recent years, and $GGE$ reflects climbing pressure and regional differences. Secondly, increasing the vertical fiscal decentralization of local governments promotes $GGE$ growth, while increasing fiscal freedom hinders it. Additionally, fiscal decentralization in neighboring cities also affects local $GGE$, with spatial spillover effects. Finally, the impact of fiscal decentralization on $GGE$ is spatio-temporally heterogeneous. This paper expands on the research regarding the factors that affect the efficiency of green growth in China, specifically focusing on institutional factors at a theoretical level. Additionally, this paper provides targeted policy recommendations based on the aforementioned findings. These recommendations hold great practical significance for China in improving its fiscal decentralization system and achieving sustainable economic development. Full article

The digital application gap and relative poverty caused by the development of digital technology are both important factors affecting sustainable economic dynamics. This paper explores the impact of digital technology development on the relative poverty of urban households in China, using the China Household Tracking Survey CFPS2010–2018 and the word frequency crawling technology of Python software. The results indicate that failure to adapt to the demands of digital technology may result in a multidimensional digital technology application gap, leading to increased income inequality among urban households and a higher likelihood of relative poverty. In economically developed areas, households headed by individuals with low levels of education and high levels of family support should be particularly mindful of the phenomenon of digital poverty. This paper expands the research scope of relative poverty and deepens the understanding of the relationship between digital technology and economic development, which is beneficial for the government to accelerate the construction of internal and external support mechanisms and to effectively address the challenges posed by sustainable economic development. Full article

The development of high-performance rubber composites has always been a research hotspot in the field of conveyor belt manufacturing. In this work, a rubber cover joint composite made of reduced graphene oxide (rGO) was prepared using latex mixing and mechanical blending methods, with a steel wire rope conveyor belt as the research object, and the influence of the rGO content on the properties of the rubber composite is discussed. The structure and morphology characterization of the rGO/NR rubber show that the addition of rGO does not change its crystal structure, and 1.2 phr rGO is uniformly dispersed throughout the rubber composite. As more rGO is added, the mechanical properties of the rGO rubber cover joint first improve and then worsen. With the addition of 1.2 phr, the cross-linking density increases by 80.6%, the tensile strength of the rubber composites increases by 49.7%, the elongation at break increases by 23.6%, and the adhesion strength increases by 12.4%. The tensile strength of the rGO rubber cover joint can still maintain 72.5% of its pre-thermal aging value. The wear resistance and thermal conductivity increase as more phr is added. When 3.0 phr is added, the wear resistance of the rubber composites increases by 32.9%, the thermal conductivity increases by 118.8%, and the temperature difference at the completion of vulcanization decreases from 4.5 °C to 1.8 °C. The results show that when 1.2 phr of rGO is added, the rubber conveyor belt joint obtains the best comprehensive performance. These enhanced comprehensive properties allow for the practical application of rGO nanomaterials to conveyor belt rubber. Full article

Objective: We aimed to identify the incidence and risk factors of perianal pathology during pregnancy and the postpartum period. Methods: A prospective cohort study was conducted in three institutions in Lithuania. A total of 190 patients were examined and interviewed three times (<12, 18–20 weeks of gestation, and during the first 2 months after delivery). They completed a questionnaire including demographic, obstetric, coloproctological, and birth data. Results: A total of 73 (34.59%) women developed hemorrhoidal disease after delivery, and 120 (56.87%) developed perianal pathology. Multivariate analysis identified a neonatal birth weight ≥3380 g (OR 4.22; 95% CI 1.83–9.71, p < 0.001) and consumption of eggs (OR 3.10; 95% CI 1.13–8.53, p = 0.028) or cereals (OR 2.87; 95% CI 1.32–6.25, p = 0.008) several times per week as significant risk factors for hemorrhoidal disease. Neonatal birth weight ≥3380 g (OR 3.95; 95% CI 1.47–10.59, p = 0.006), maternal BMI ≥ 21.48 (OR 3.58; 95% CI 1.51–8.47, p = 0.004), the duration of the second labor period ≥38 min (OR 2.81; 95% CI 1.09–7.23, p = 0.032), and consumption of flour products several times per week (OR 2.77; 95% CI 1.10–6.98, p = 0.030) were associated with a higher risk of perianal pathology. Daily consumption of fruits and vegetables (OR 0.35; 95% CI 0.15–0.81, p = 0.014) and less frequent consumption of eggs were protective factors (OR 0.18; 95% CI 0.06–0.56, p = 0.003). Conclusions: Perianal diseases, especially hemorrhoidal disease, are common during pregnancy and the postpartum period. A neonatal birth weight ≥ 3380 g, a maternal BMI of ≥21.48, duration of the second labor period of ≥38 min, and consumption of flour products and cereals several times a week are risk factors for developing these diseases. Full article

Optical hydrogen sensors offer high sensitivity, high accuracy, and non-invasive sensing capabilities, making them promising devices in various fields, including the construction of hydrogen fuel cells, storage and transportation, and aerospace. However, to achieve better sensitivity and faster reaction times, such sensors are often constructed as nano-arrays or nano-gratings, leading to increased manufacturing costs and complexity. In this study, we propose and demonstrate a highly sensitive hydrogen sensor based on a multilayer structure. The proposed structure consists of a Pd metal film and a photonic crystal with a defect layer, in which the photonic crystal is designed by an alternating arrangement of Ta₂O₅ and SiO₂, and the material comprising the defect layer is SiO₂. With a sensitivity of up to 16,020 at 670 nm, the proposed sensor relies on the coupling of Tamm plasmon polaritons and defect modes. The electric field distribution inside the structure is also provided in order to reveal its physical mechanism. Furthermore, we investigate the effects of the thickness of the defect layer and the angle of incident light on the sensor’s performance. The study results show that the sensor has good fault tolerance in either scenario. The findings of this study open up new possibilities for hydrogen sensor applications. Full article

Social media platforms have surpassed cultural and linguistic boundaries, thus enabling online communication worldwide. However, the expanded use of various languages has intensified the challenge of online detection of hate speech content. Despite the release of multiple Natural Language Processing (NLP) solutions implementing cutting-edge machine learning techniques, the scarcity of data, especially labeled data, remains a considerable obstacle, which further requires the use of semisupervised approaches along with Generative Artificial Intelligence (Generative AI) techniques. This paper introduces an innovative approach, a multilingual semisupervised model combining Generative Adversarial Networks (GANs) and Pretrained Language Models (PLMs), more precisely mBERT and XLM-RoBERTa. Our approach proves its effectiveness in the detection of hate speech and offensive language in Indo-European languages (in English, German, and Hindi) when employing only 20% annotated data from the HASOC2019 dataset, thereby presenting significantly high performances in each of multilingual, zero-shot crosslingual, and monolingual training scenarios. Our study provides a robust mBERT-based semisupervised GAN model (SS-GAN-mBERT) that outperformed the XLM-RoBERTa-based model (SS-GAN-XLM) and reached an average F1 score boost of 9.23% and an accuracy increase of 5.75% over the baseline semisupervised mBERT model. Full article

Rising wildfire incidents in South America, potentially exacerbated by climate change, require an exploration of sustainable approaches for fire risk reduction. This study investigates wildfire-prone meteorological conditions and assesses the susceptibility in Colombia’s megadiverse northern region. Utilizing this knowledge, we apply a machine learning model and the Monte Carlo approach to evaluate sustainability strategies for mitigating fire risk. The findings indicate that a substantial number of fires occur in the southern region, especially in the first two seasons of the year, and in the northeast in the last two seasons. Both are characterized by high temperatures, minimal precipitation, strong winds, and dry conditions. The developed model demonstrates significant predictive accuracy with the HIT, FAR, and POC of 87.9%, 28.3%, and 95.7%, respectively, providing insights into the probabilistic aspects of fire development. Various scenarios showed that a decrease in soil temperature reduces the risk mostly in lower altitudes and leaf skin reservoir content in the highest altitudes, as well as in the north region. Sustainability strategies, such as tree belts, agroforestry mosaics, and forest corridors emerge as crucial measures. The results underscore the importance of proactive measures in mitigating wildfire impact, offering actionable insights for crafting effective sustainability strategies amid escalating fire risks. Full article

Colorectal cancer (CRC) is the second leading cause of cancer deaths worldwide. Although the overall incidence of CRC is decreasing, the incidence of young-onset CRC, characterized by a diagnosis of CRC before age 50, is increasing. Outcomes for CRC patients are improving, partly due to comprehensive molecular characterization of tumors and novel therapeutic strategies. Advances in genomic and transcriptomic analyses using blood- and tumor-tissue-based sequencing have facilitated identification of distinct tumor subtypes harboring unique biological characteristics and therapeutic vulnerabilities. These insights have led to the development and incorporation of targeted therapies and immunotherapy in CRC treatment. In this review, we discuss the molecular landscape and key oncogenes/tumor suppressors contributing to CRC tumorigenesis, metastasis, and therapeutic resistance. We also discuss personalized therapeutic strategies for subsets of CRC patients and provide an overview of evolving novel treatments being evaluated in clinical trials. Full article

Treating brain disease is challenging, and the Zika virus (ZIKV) presents a unique obstacle due to its neuroinvasive nature. In this review, we discuss the immunopathogenesis of ZIKV and explore how the virus interacts with the body’s immune responses and the role of the protein Mfsd2a in maintaining the integrity of the blood–brain barrier (BBB) during ZIKV neuroinvasion. ZIKV has emerged as a significant public health concern due to its association with severe neurological problems, including microcephaly and Gillain–Barré Syndrome (GBS). Understanding its journey through the brain—particularly its interaction with the placenta and BBB—is crucial. The placenta, which is designed to protect the fetus, becomes a pathway for ZIKV when infected. The BBB is composed of brain endothelial cells, acts as a second barrier, and protects the fetal brain. However, ZIKV finds ways to disrupt these barriers, leading to potential damage. This study explores the mechanisms by which ZIKV enters the CNS and highlights the role of transcytosis, which allows the virus to move through the cells without significantly disrupting the BBB. Although the exact mechanisms of transcytosis are unclear, research suggests that ZIKV may utilize this pathway. Full article

The paper departs from the observation that the role of migrant organisations (MOs) in Germany has changed significantly since the strong influx of refugees in 2015/16. As a result of this specific historical situation, it seems that MOs were able to strengthen their position as important civil society and integration policy actors and reduce reservations about them. While there has been growing attention on MOs’ civic and social contributions, both in public and academic debates, this article also highlights the risks of failure and inflated expectations and the often rather fragile structures of MOs. Thus, the article aims to broaden the view on MOs by focusing on aspects which have been neglected in the course of recent public and academic interest and rather optimistic perceptions. The methodological approach is one of “embedded research”: the author has been a senior executive of one of the largest German MOs for six years and, at the same time, a migration researcher for many years. From this special inside/outside view, an ambivalent picture emerges: despite a significantly greater appreciation of the achievements of MOs and much verbal recognition, there is a clear lack of the necessary material/structural support, jeopardising the sustainability and viability of many MOs. Full article

During the last two decades, several cases of venous thrombosis (VTE) after a prolonged period at a computer have been described, denominated as “eThrombosis”. Video gaming on a computer has become very popular and can be a social activity where several players gather to play against each other or in a virtual environment for several days (“LAN (i.e., Local Area Network) parties”) where the participants are sedentary and consuming calorie-rich food items. The aim of this study was to investigate potential coagulation activation during a 42 h LAN party. Nine male gamers volunteered for the LAN party. Citrated blood was sampled before and every 6 h, and plasma was analyzed for thrombin generation, thrombin–antithrombin complexes (TAT), prothrombin fragment 1 + 2 (F1 + 2), and D-dimer. Thrombin generation increased slightly but not significantly during the LAN party, whereas the coagulation activation markers were unchanged. These results do not indicate that the coagulation system is activated significantly during 42 h of gaming with minimal physical activity. Although increased activity cannot be excluded, it does not directly indicate a risk of VTE in general. Full article