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most exciting work published in the various research areas of the journal.
Wild boars have become a common yet controversial species in France, where the main response to the species’ development and the problems it may cause is an increased hunting effort. However, wild boars are an extremely adaptive species, and their response to human
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Wild boars have become a common yet controversial species in France, where the main response to the species’ development and the problems it may cause is an increased hunting effort. However, wild boars are an extremely adaptive species, and their response to human activities (including hunting) is not fully understood. Moreover, hunting may be a source of conflict with other stakeholders and a topic for public debate, which questions its sustainability. To discuss wild boar behaviour, as well as (other) means to coexist with these animals, we developed a role-playing board game framed around wild boars and hunting. In this paper, we outline the design of the WILD BOAR(D) GAME and reflect on the first three game sessions, which we conducted in our research areas (Gorges du Gardon and Camargue Biosphere Reserves, France). We show that a continuous back and forth between the game and reality allows the participants to elicit their knowledge as well as learn from the other participants, which contributes to filling in the knowledge gaps identified previously in the game design as well as mitigating conflicts regarding wild boars. Finally, we discuss the interest of including wild boars as a role in itself to reflect on their agency.
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Fault diagnosis can improve the safety and reliability of diesel engines. An end-to-end method based on a multi-attention convolutional neural network (MACNN) is proposed for accurate and efficient diesel engine fault diagnosis. By optimizing the arrangement and kernel size of the channel and
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Fault diagnosis can improve the safety and reliability of diesel engines. An end-to-end method based on a multi-attention convolutional neural network (MACNN) is proposed for accurate and efficient diesel engine fault diagnosis. By optimizing the arrangement and kernel size of the channel and spatial attention modules, the feature extraction capability is improved, and an improved convolutional block attention module (ICBAM) is obtained. Vibration signal features are acquired using a feature extraction model alternating between the convolutional neural network (CNN) and ICBAM. The feature map is recombined to reconstruct the sequence order information. Next, the self-attention mechanism (SAM) is applied to learn the recombined sequence features directly. A Swish activation function is introduced to solve “Dead ReLU” and improve the accuracy. A dynamic learning rate curve is designed to improve the convergence ability of the model. The diesel engine fault simulation experiment is carried out to simulate three kinds of fault types (abnormal valve clearance, abnormal rail pressure, and insufficient fuel supply), and each kind of fault varies in different degrees. The comparison results show that the accuracy of MACNN on the eight-class fault dataset at different speeds is more than 97%. The testing time of the MACNN is much less than the machine running time (for one work cycle). Therefore, the proposed end-to-end fault diagnosis method has a good application prospect.
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Exploring the ocean’s resources requires finding underwater objects, which is a challenging task due to blurry images and small, densely packed targets. To improve the accuracy of underwater target detection, we propose an enhanced version of the YOLOv7 network called YOLOv7-SN. Our goal
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Exploring the ocean’s resources requires finding underwater objects, which is a challenging task due to blurry images and small, densely packed targets. To improve the accuracy of underwater target detection, we propose an enhanced version of the YOLOv7 network called YOLOv7-SN. Our goal is to optimize the effectiveness and accuracy of underwater target detection by introducing a series of innovations. We incorporate the channel attention module SE into the network’s key part to improve the extraction of relevant features for underwater targets. We also introduce the RFE module with dilated convolution behind the backbone network to capture multi-scale information. Additionally, we use the Wasserstein distance as a new metric to replace the traditional loss function and address the challenge of small target detection. Finally, we employ probe heads carrying implicit knowledge to further enhance the model’s accuracy. These methods aim to optimize the efficacy of underwater target detection and improve its ability to deal with the complexity and challenges of underwater environments. We conducted experiments on the URPC2020, and RUIE datasets. The results show that the mean accuracy (mAP) is improved by 5.9% and 3.9%, respectively, compared to the baseline model.
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The properties of small size, low noise, high performance and no wear-out have made the hemispherical resonator gyroscope a good choice for high-value space missions. To enhance the precision of the hemispherical resonator gyroscope for use in tasks with large angular velocities and
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The properties of small size, low noise, high performance and no wear-out have made the hemispherical resonator gyroscope a good choice for high-value space missions. To enhance the precision of the hemispherical resonator gyroscope for use in tasks with large angular velocities and angular accelerations, this paper investigates the standing wave precession of a non-ideal hemispherical resonator under nonlinear high-intensity dynamic conditions. Based on the thin shell theory of elasticity, a dynamic model of a hemispherical resonator is established by using Lagrange’s second kind equation. Then, the dynamic model is equivalently transformed into a simple harmonic vibration model of a point mass in two-dimensional space, which is analyzed using a method of averaging that separates the slow variables from the fast variables. The results reveal that taking the nonlinear terms about the square of the angular velocity and the angular acceleration in the dynamic equation into account can weaken the influence of the 4th harmonic component of a mass defect on standing wave drift, and the extent of this weakening effect varies with the dimensions of the mass defects, which is very important for steering the development of the high-precision hemispherical resonator gyroscope.
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Background: This paper examines scientific papers in the field of digital twins to explore the different areas of application in supply chains. Methods: Using a machine learning-based topic modeling approach, this study aims to provide insights into the key areas of supply chain
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Background: This paper examines scientific papers in the field of digital twins to explore the different areas of application in supply chains. Methods: Using a machine learning-based topic modeling approach, this study aims to provide insights into the key areas of supply chain management that benefit from digital twin capabilities. Results: The research findings highlight key priorities in the areas of infrastructure, construction, business, technology, manufacturing, blockchain, and agriculture, providing a comprehensive perspective. Conclusions: Our research findings confirm several recommendations. First, the machine learning-based model identifies new areas that are not addressed in the human review results. Second, while the human review results put more emphasis on practicality, such as management activities, processes, and methods, the machine learning results pay more attention to macro perspectives, such as infrastructure, technology, and business. Third, the machine learning-based model is able to extract more granular information; for example, it identifies core technologies beyond digital twins, including AI/reinforcement learning, picking robots, cybersecurity, 5G networks, the physical internet, additive manufacturing, and cloud manufacturing.
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Like many developing nations, Egypt is facing a climate crisis due to its agricultural dependence and the Nile Delta’s vulnerability. Despite government plans for sustainable development, recent infrastructure projects have resulted in large-scale green space removal. Effective communication about environmental issues can spark
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Like many developing nations, Egypt is facing a climate crisis due to its agricultural dependence and the Nile Delta’s vulnerability. Despite government plans for sustainable development, recent infrastructure projects have resulted in large-scale green space removal. Effective communication about environmental issues can spark pro-environmental behavior and citizen activism. This study explores social media’s potential to bridge this gap in Egypt. Utilizing Facebook AB testing with a limited budget, we reached a significant 2.3% of Egypt’s online population (nearly 2 million users). This study explored message framing, with findings showing that rational posts resonated best while fear appeals had minimal impact. Social media’s cost-effectiveness and message-framing consideration provide a strategic approach for NGOs to reach a large audience and encourage climate action in Egypt.
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2 Kings 20:1–11; Isaiah 38:1–22 and 2 Chronicles 32:24–26 discuss Hezekiah’s sickness and the power of healing prayer. They are called Hezekiah-Isaiah narratives since they deal not only with (a) the threats and salvation of Jerusalem from Assyria, (b) the disease and the
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2 Kings 20:1–11; Isaiah 38:1–22 and 2 Chronicles 32:24–26 discuss Hezekiah’s sickness and the power of healing prayer. They are called Hezekiah-Isaiah narratives since they deal not only with (a) the threats and salvation of Jerusalem from Assyria, (b) the disease and the miraculous recovery or healing (ḥāyâ/rāքā’) of Hezekiah and description of the representatives from Babylon, but share a common narrative pattern in which Hezekiah is healed with a poultice/lump of fig tree (dəbelet təʾnim), having received advise and healing support from God’s messenger, Isaiah. Past scholars have approached this text differently, searching for its dating, literary growths, differences, originality with the desire to reveal the history of the various traditional components and relationship among parallel texts, as well the prophetic and kingly images of Isaiah and Hezekiah. Built on this past scholarship and African cultural perspectives and experiences, this work contextually, historically and theologically study, develop and analyze the story of Hezekiah’s sickness and healing.
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The integration of the Arduino board into educational settings has penetrated across various educational levels. The teaching of this subject can be accomplished by (a) using real components in breadboards, (b) prefabricated modular boards that snap together, and (c) utilizing computer simulations. Yet,
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The integration of the Arduino board into educational settings has penetrated across various educational levels. The teaching of this subject can be accomplished by (a) using real components in breadboards, (b) prefabricated modular boards that snap together, and (c) utilizing computer simulations. Yet, it is unknown which interface offers a more effective learning experience. Therefore, this experimental study aims to compare the effectiveness of these interfaces in a series of three laboratory exercises involving 110 university students, who were divided into three groups: (a) the first group used a tangible user interface, implementing circuits on breadboards, (b) the second group also used a tangible interface but with modular boards, and (c) the third group used a graphical user interface to simulate circuits using Tinkercad. For each laboratory exercise, students completed both pretests and posttests. Also, they provided feedback through five Likert-type attitude questions regarding their experiences. In terms of data analysis, t-tests, ANOVA, and ANCOVA, along with bootstrapping, and principal component analysis were employed. The results suggest that among the participants, those who used a graphical user interface stated that their understanding of the interconnection of components in microcontroller circuits was enhanced, while students with previous experience in microcontroller labs found the circuit creation process easier than students without experience.
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Spontaneous detachment from superhydrophobic surfaces can be induced by the coalescence of two or more adjacent droplets. The phenomena have provided implications for the self-removal of droplets in the fields of self-cleaning, anti-icing, and heat transfer. However, many studies focus mainly on the
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Spontaneous detachment from superhydrophobic surfaces can be induced by the coalescence of two or more adjacent droplets. The phenomena have provided implications for the self-removal of droplets in the fields of self-cleaning, anti-icing, and heat transfer. However, many studies focus mainly on the theoretical jumping direction perpendicular to the substrate, although the velocity in the horizontal direction must be involved in practical applications due to various scenarios. This study analyzes numerically the effect of the distribution in ridge structure’s wettability on the performance of coalesced droplet jumping. The jumping dynamics are discussed for varying contact angle ratios and the aspect ratios of the ridge, which are the initial values for the current model. We obtain the height of the jumping and the offset distance in the horizontal direction under the several initial values. In addition, the characteristics of the asymmetric behavior are discussed based on the temporal evolution of the average velocities of the jumping droplets for each direction. Numerical results show that the horizontal offset distance is significantly pronounced at both the high asymmetry in wettability and the high aspect ratio of the ridge geometry. The phenomenon occurs when the droplet detaches from the ridge surface in the retraction process. We determine the role of the distribution within the ridge structure on its wettability, as well as the role of the aspect ratios of the ridge in facilitating the efficient transport of droplets.
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Dairy products are highly susceptible to contamination from microorganisms. This study aimed to evaluate the efficacy of hydroxypropyl methylcellulose (HPMC) and propolis film as protective coatings for cheese. For this, microbiological analyses were carried out over the cheese’ ripening period, focusing on total
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Dairy products are highly susceptible to contamination from microorganisms. This study aimed to evaluate the efficacy of hydroxypropyl methylcellulose (HPMC) and propolis film as protective coatings for cheese. For this, microbiological analyses were carried out over the cheese’ ripening period, focusing on total mesophilic bacteria, yeasts and moulds, lactic acid bacteria, total coliforms, Escherichia coli, and Enterobacteriaceae. Physicochemical parameters (pH, water activity, colour, phenolic compounds content) were also evaluated. The statistical analysis (conducted using ANOVA and PERMANOVA) showed a significant interaction term between the HPMC film and propolis (factor 1) and storage days (factor 2) with regard to the dependent variables: microbiological and physicochemical parameters. A high level of microbial contamination was identified at the baseline. However, the propolis films were able to reduce the microbial count. Physicochemical parameters also varied with storage time, with no significant differences found for propolis-containing films. Overall, the addition of propolis to the film influenced the cheeses’ colour and the quantification of phenolic compounds. Regarding phenolic compounds, their loss was verified during storage, and was more pronounced in films with a higher percentage of propolis. The study also showed that, of the three groups of phenolic compounds (hydroxybenzoic acids, hydroxycinnamic acids, and flavonoids), hydroxycinnamic acids showed the most significant losses. Overall, this study reveals the potential of using HPMC/propolis films as a coating for cheese in terms of microbiological control and the preservation of physicochemical properties.
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The dynamic stress–strain state and fracture of a steel main gas pipe section between supports with a straight-through crack was analyzed with consideration of the temperature effect on changes in the mechanical properties of the pipe material. The numerical solution of the problem
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The dynamic stress–strain state and fracture of a steel main gas pipe section between supports with a straight-through crack was analyzed with consideration of the temperature effect on changes in the mechanical properties of the pipe material. The numerical solution of the problem was implemented in the ANSYS-19.2/Explicit Dynamics software package. The process of fracture in a section of the gas pipeline “Beineu–Bozoy–Shymkent” with a linear crack in the temperature range of −40 °C to +50 °C at the operating pressure of 7.5 MPa and critical pressure equal to 9.8 MPa was considered. As a result, it was found that at the initial growth of the internal pressure from working pressure to critical pressure, the length of the crack doubled. At the same time, the process had a local characteristic. Further development of the crack had the nature of avalanche fracture and depended on the temperature of the steel pipeline. With increasing temperature, there was also an increase in the length of the crack at the avalanche fracture. Thus, at a temperature of 40 °C, the crack lengthened 67.75-fold; at a temperature of −10 °C, the crack lengthened 68-fold; at a temperature of +20 °C, the crack lengthened 68.25-fold; and at a temperature of +50 °C, the crack lengthened 68.5-fold. In this work, this difference was 75% of the initial crack length. This fact will be used for further development of the technique of strengthening damaged pipe sections using bandages.
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Gaze tracking of high-speed moving targets is a novel application mode for low Earth orbit microsatellites. In this mode, small satellites are equipped with high-resolution, narrow-field-of-view video cameras for stable gaze-tracking imaging of high-speed moving targets. This paper proposes a high-precision attitude adaptive
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Gaze tracking of high-speed moving targets is a novel application mode for low Earth orbit microsatellites. In this mode, small satellites are equipped with high-resolution, narrow-field-of-view video cameras for stable gaze-tracking imaging of high-speed moving targets. This paper proposes a high-precision attitude adaptive integral sliding mode control method with a feedforward compensation disturbance observer to enhance the capability of a microsatellite attitude control system for gaze tracking of high-speed moving targets. Specifically, first, we present the attitude control system model for microsatellites and the calculation method for the desired attitude of target tracking based on image feedback. Then, an adaptive integral sliding mode attitude control algorithm with a feedforward compensation disturbance observer, which meets the requirements of high-precision tracking control, is designed. The developed algorithm utilizes the disturbance observer to observe the friction torque of the flywheel and compensates for it through feedforward control. It also employs the adaptive integral sliding mode control algorithm to reduce the impact of uncertain disturbances, decrease the steady-state error of the system, and enhance attitude control precision. Simulation experiments demonstrated that the designed disturbance observer can successfully observe the frictional disturbance torque of the flywheel. The attitude Euler angle control precision for high-speed moving target tracking reached 0.03°, and the angular velocity control precision reached 0.005°/s, validating the effectiveness of the proposed approach.
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In the past five decades, global food systems have undergone a notable transition, moving from predominantly rural settings to increasingly urban and industrialized environments, largely driven by processes of globalization and supply chain integration. However, this evolution has not adequately addressed equitable access
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In the past five decades, global food systems have undergone a notable transition, moving from predominantly rural settings to increasingly urban and industrialized environments, largely driven by processes of globalization and supply chain integration. However, this evolution has not adequately addressed equitable access to nutritious diets and food environments, resulting in adverse health outcomes. This study delves into the spatial and non-spatial barriers that impede the adoption of healthy diets in the Noreste of Mexico, particularly focusing on the challenges associated with accessing and cultivating plant-based foods. Through an examination of suitable areas for urban agriculture and an exploration of the socio-cultural factors influencing the adoption of plant-based diets, the research focuses on interventions aimed at promoting healthier and more sustainable eating practices in Monterrey. The findings of the study reveal significant disparities in food access across the Monterrey metropolitan area, with central urban zones exhibiting superior access to fresh foods compared to suburban and peripheral regions. This inequality disproportionately affects marginalized areas characterized by higher poverty rates, exacerbating issues of food insecurity. Nevertheless, traditional dietary practices could offer promising avenues for creating culturally significant and healthier dietary transitions, even amidst the ongoing process of urbanization.
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Since 2013, 34 surveys of surface and ground waters within and outside the former Hg-mine of Abbadia San Salvatore (Italy), which is currently under remediation, were performed for determining Hg, As, Sb, and main and minor solutes. The water quality is rather poor
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Since 2013, 34 surveys of surface and ground waters within and outside the former Hg-mine of Abbadia San Salvatore (Italy), which is currently under remediation, were performed for determining Hg, As, Sb, and main and minor solutes. The water quality is rather poor since most waters show relatively high Hg concentrations (up to 695 µg/L). Differently, As and Sb only overcome the Italian law thresholds in a few sites. A high geochemical variability was observed for most groundwaters without any clear relationship between wet and dry periods. The main source of chalcophile elements is likely related to: (i) the interaction between meteoric waters and soils contaminated by the previous production of mercury; or (ii) the interaction between meteoric waters and the anthropic filling material of a former paleo-valley near the furnaces edifices. While the remediation is expected to be concluded in 2025, the aquifer contamination still remains a problem. Our investigation, including geochemical/hydrogeological modeling, is prodromal to future activities aimed at reducing the Hg content. Currently, the construction of a hydraulic barrier is apparently the most suitable solution to minimize the interaction processes between water–rock and man-made material, which are responsible for the 10-year concentration variability.
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To address the ecological challenges arising from pure forest plantations and the wood supply–demand imbalance, implementing sustainable forest management is paramount. Accordingly, we studied crop trees at three densities (100, 150, and 200 N/ha) in a subtropical Pinus massoniana plantation. Our study revealed
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To address the ecological challenges arising from pure forest plantations and the wood supply–demand imbalance, implementing sustainable forest management is paramount. Accordingly, we studied crop trees at three densities (100, 150, and 200 N/ha) in a subtropical Pinus massoniana plantation. Our study revealed that the dominant phyla and genera within the fungal community remained largely consistent, with Basidiomycota and Ascomycota occupying prominent positions. Notably, the β diversity of the fungal community exhibited significant changes. Ectomycorrhizal and saprophytic fungi emerged as crucial functional guilds, and crop-tree thinning contributed to increased complexity within the fungal network, with a prevalence of positive rather than negative correlations among genera. The significant roles played by Camphor plants and ferns were evident in the fungal networks. Additionally, under crop-tree thinning, plant diversity experienced a significant boost, fostering interactions with the fungal community. Herb diversity played a vital role in the fungal community, affecting it either directly or indirectly, by altering the content of total phosphorus or organic matter in the soil. This study underscores the relationship between undergrowth plants and soil fungal communities, offering a scientific basis for evaluating the sustainability of restoring inefficient forest-plantation ecosystems.
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Background: Epileptic encephalopathies (EE) are characterized by severe drug-resistant seizures, early onset, and unfavorable developmental outcomes. This article discusses the use of intravenous methylprednisolone (IVMP) pulse therapy in pediatric patients with EE to evaluate its efficacy and tolerability. Methods: This is a retrospective
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Background: Epileptic encephalopathies (EE) are characterized by severe drug-resistant seizures, early onset, and unfavorable developmental outcomes. This article discusses the use of intravenous methylprednisolone (IVMP) pulse therapy in pediatric patients with EE to evaluate its efficacy and tolerability. Methods: This is a retrospective study from 2020 to 2023. Inclusion criteria were ≤18 years at the time of IVMP pulse therapy and at least 6 months of follow-up. Efficacy and outcome, defined as seizure reduction > 50% (responder rate), were evaluated at 6 and 9 months of therapy, and 6 months after therapy suspension; quality of life (QoL) was also assessed. Variables predicting positive post-IVMP outcomes were identified using statistical analysis. Results: The study included 21 patients, with a responder rate of 85.7% at 6 and 9 months of therapy, and 80.9% at 6 months after therapy suspension. Variables significantly predicting favorable outcome were etiology (p = 0.0475) and epilepsy type (p = 0.0475), with the best outcome achieved in patients with genetic epilepsy and those with encephalopathy related to electrical status epilepticus during slow-wave sleep (ESES). All patients evidenced improvements in QoL at the last follow-up, with no relevant adverse events reported. Conclusions: Our study confirmed the efficacy and high tolerability of IVMP pulse therapy in pediatric patients with EE. Genetic epilepsy and ESES were positive predictors of a favorable clinical outcome. QOL, EEG tracing, and postural–motor development showed an improving trend as well. IVMP pulse therapy should be considered earlier in patients with EE.
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The study explores the novel use of oak bark (Quercus cortex) as a bio-filler in elastomeric composites, aligning with the global trend of plant-based biocomposites. Both modified and unmodified oak bark were investigated for their impact on the physicochemical properties of natural rubber
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The study explores the novel use of oak bark (Quercus cortex) as a bio-filler in elastomeric composites, aligning with the global trend of plant-based biocomposites. Both modified and unmodified oak bark were investigated for their impact on the physicochemical properties of natural rubber (NR) composites. The bio-filler modified with n-octadecyltrimethoxysilane exhibited enhanced dispersion and reduced aggregates in the elastomeric matrix. NR composites containing more than 20 phr of unmodified and modified oak bark demonstrated an increased degree of cross-linking (αc > 0.21). Mechanical properties were optimal at 10–15 phr of oak bark and the sample with modified bio-filler (10 phr) achieved the highest tensile strength (15.8 MPa). Silanization and the addition of the bio-filler increased the hardness of vulcanizates. The incorporation of oak bark improved aging resistance at least two-fold due to phenolic derivatives with antioxidant properties. Hydrophobicity decreased with added bark, but silanization reversed the trend, making samples with a high content of oak bark the most hydrophobic (contact angle: 129°). Overall, oak bark shows promise as an eco-friendly, anti-aging filler in elastomeric composites, with modification enhancing compatibility and hydrophobicity.
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(This article belongs to the Section Biomaterials)
Lignocellulosic-based polymer composites have gained significant interest due to their ‘’green’’ character as a response to environmental concerns. A diverse array of lignocellulosic fibers is utilized, depending on fiber dimensions, chemical composition, moisture content, and the fiber–matrix interface. The aim of this study
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Lignocellulosic-based polymer composites have gained significant interest due to their ‘’green’’ character as a response to environmental concerns. A diverse array of lignocellulosic fibers is utilized, depending on fiber dimensions, chemical composition, moisture content, and the fiber–matrix interface. The aim of this study is to establish an alternative standardized methodology, aimed at comparatively estimating the performance of polymer composites through the examination of individual plant fibers. The fibers studied are ramie, hemp, flax, and kenaf, and HDPE-based corresponding composites were analyzed for their performance across various fiber-content levels (10, 20, and 30 wt.%). It was found that kenaf showcases the largest average fiber diameter, succeeded by hemp, ramie, and flax. Additionally, ramie and kenaf exhibit elevated levels of crystallinity, suggesting increased cellulose content, with kenaf having the lowest crystallinity index among the fibers compared. Based on Thermogravimetric analysis, ramie displays the lowest moisture content among the examined fibers, followed by hemp, flax, and ultimately kenaf, which is recorded to have the highest moisture content, while, similarly, ramie exhibits the lowest mass loss at the processing temperature of the corresponding composites. Composites containing fibers with smaller diameters and higher crystallinity indexes and lower moisture absorptions, such as ramie and hemp, demonstrate superior thermal stability and exhibit increased Young’s modulus values in their respective composites. However, poor interfacial adhesion affects mechanical performance across all composites. Understanding fiber morphology, inner structure, and thermal stability is important for developing new composite materials and optimizing their selection for various applications.
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With the continuous integration of semiconductor devices, the requirements of the size accuracy and surface quality of etched lead frames are stricter. The etchant is a key factor in the etching process and etched surface quality, while the effects of the difference in
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With the continuous integration of semiconductor devices, the requirements of the size accuracy and surface quality of etched lead frames are stricter. The etchant is a key factor in the etching process and etched surface quality, while the effects of the difference in etchants on the etched surface morphology of Cu alloy have not been directly studied. In this study, aqua regia, acidic FeCl3 and two CuCl2 solutions were used as etchants, and different CuCrSn specimens were etched and characterized. The results show that the etching rate in aqua regia is high, and the grain orientation, grain boundary (GB) and dislocations have significant influences on the local etching rate. The preferential etching of some atomic planes forms steps between the grains with different orientations, and preferential etching around the GB and dislocation group forms grooves, resulting in high surface roughness. For the surfaces etched by the FeCl3 and CuCl2 etchants, the steps and grooves are blurred; thus, they are less rough. The CuCrSn alloy surface etched by the aqua regia is clean, with little Cr-rich particles, while high-density Cr-rich particles remain on the surfaces etched by the FeCl3 and CuCl2 etchants. For the same kind of etchant, the ion concentration can affect the etching mechanism, rate and the etched surface morphology.
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by
Ángela-Patricia Hernández, Lorea Chaparro-González, Olga Garzo-Sánchez, Carlota Arias-Hidalgo, Pablo Juanes-Velasco, Pablo A. García, Mª Ángeles Castro and Manuel Fuentes
When new antitumor therapy drugs are discovered, it is essential to address new target molecules from the point of view of chemical structure and to carry out efficient and systematic evaluation. In the case of natural products and derived compounds, it is of
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When new antitumor therapy drugs are discovered, it is essential to address new target molecules from the point of view of chemical structure and to carry out efficient and systematic evaluation. In the case of natural products and derived compounds, it is of special importance to investigate chemomodulation to further explore antitumoral pharmacological activities. In this work, the compound podophyllic aldehyde, a cyclolignan derived from the chemomodulation of the natural product podophyllotoxin, has been evaluated for its viability, influence on the cell cycle, and effects on intracellular signaling. We used functional proteomics characterization for the evaluation. Compared with the FDA-approved drug etoposide (another podophyllotoxin derivative), we found interesting results regarding the cytotoxicity of podophyllic aldehyde. In addition, we were able to observe the effect of mitotic arrest in the treated cells. The use of podophyllic aldehyde resulted in increased cytotoxicity in solid tumor cell lines, compared to etoposide, and blocked the cycle more successfully than etoposide. High-throughput analysis of the deregulated proteins revealed a selective antimitotic mechanism of action of podophyllic aldehyde in the HT-29 cell line, in contrast with other solid and hematological tumor lines. Also, the apoptotic profile of podophyllic aldehyde was deciphered. The cell death mechanism is activated independently of the cell cycle profile. The results of these targeted analyses have also shown a significant response to the signaling of kinases, key proteins involved in signaling cascades for cell proliferation or metastasis. Thanks to this comprehensive analysis of podophyllic aldehyde, remarkable cytotoxic, antimitotic, and other antitumoral features have been discovered that will repurpose this compound for further chemical transformations and antitumoral analysis.
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In this paper, we concentrate on the propagation dynamics of stochastic reaction–diffusion equations, including the existence of travelling wave solution and asymptotic wave speed. Based on the stochastic Feynman–Kac formula and comparison principle, the boundedness of the solution of stochastic reaction–diffusion equations can
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In this paper, we concentrate on the propagation dynamics of stochastic reaction–diffusion equations, including the existence of travelling wave solution and asymptotic wave speed. Based on the stochastic Feynman–Kac formula and comparison principle, the boundedness of the solution of stochastic reaction–diffusion equations can be obtained so that we can construct a sup-solution and a sub-solution to estimate the upper bound and the lower bound of wave speed.
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Two-dimensional superconductors, especially the covalent metals such as borophene, have received significant attention due to their new fundamental physics, as well as potential applications. Furthermore, the bilayer borophene has recently ignited interest due to its high stability and versatile properties. Here, the mechanical
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Two-dimensional superconductors, especially the covalent metals such as borophene, have received significant attention due to their new fundamental physics, as well as potential applications. Furthermore, the bilayer borophene has recently ignited interest due to its high stability and versatile properties. Here, the mechanical and superconducting properties of bilayer- borophene are explored by means of first-principles computations and anisotropic Migdal–Eliashberg analytics. We find that the coexistence of strong covalent bonds and delocalized metallic bonds endows this structure with remarkable mechanical properties (maximum 2D-Young’s modulus of ~570 N/m) and superconductivity with a critical temperature of ~20 K. Moreover, the superconducting critical temperature of this structure can be further boosted to ~46 K by applied strain, which is the highest value known among all borophenes or two-dimensional elemental materials.
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The suboptimal performance of rotavirus (RV) vaccines in developing countries and in animals necessitates further research on the development of novel therapeutics and control strategies. To initiate infection, RV interacts with cell-surface O-glycans, including histo-blood group antigens (HBGAs). We have previously demonstrated
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The suboptimal performance of rotavirus (RV) vaccines in developing countries and in animals necessitates further research on the development of novel therapeutics and control strategies. To initiate infection, RV interacts with cell-surface O-glycans, including histo-blood group antigens (HBGAs). We have previously demonstrated that certain non-pathogenic bacteria express HBGA- like substances (HBGA+) capable of binding RV particles in vitro. We hypothesized that HBGA+ bacteria can bind RV particles in the gut lumen protecting against RV species A (RVA), B (RVB), and C (RVC) infection in vivo. In this study, germ-free piglets were colonized with HBGA+ or HBGA- bacterial cocktail and infected with RVA/RVB/RVC of different genotypes. Diarrhea severity, virus shedding, immunoglobulin A (IgA) Ab titers, and cytokine levels were evaluated. Overall, colonization with HBGA+ bacteria resulted in reduced diarrhea severity and virus shedding compared to the HBGA- bacteria. Consistent with our hypothesis, the reduced severity of RV disease and infection was not associated with significant alterations in immune responses. Additionally, colonization with HBGA+ bacteria conferred beneficial effects irrespective of the piglet HBGA phenotype. These findings are the first experimental evidence that probiotic performance in vivo can be improved by including HBGA+ bacteria, providing decoy epitopes for broader/more consistent protection against diverse RVs.
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