The purpose of this article is to understand administrators’ personal beliefs and experiences related to inclusive education and social justice that are critical to their commitment, the leadership provided, and types of special education services that prevail in their districts. This study is embedded within a conceptual framework centered on inclusive education, and existing theoretical framings of leadership for social justice and disability studies in education. Further, it contributes to the conversation in a recent call to reimagine educational approaches in the United States that challenge systems, focus on racial and disability justice, and serve the public good. A qualitative research methodology with in-depth interviewing as the data collection method was used to understand the lived experiences and practices of seven district-level special education leaders. It specifically looks at the leaders’ drive to carry out social justice work and their overall value-based mission of socially just, equity-oriented inclusive education at the district level. It provides a research study on (1) how leaders come to carry out social justice and disability justice work in schools, (2) poignant career events that shape their justice work, and (3) their intentions to prepare under-represented and traditionally marginalized students to engage in society. The overall premise is that since district-level leaders are vital in shaping public schooling spaces, understanding their social and disability justice grounding is critical to disrupt marginalizing practices in PreK-12. Full article

Rapid surface charge mapping of a solid surface remains a challenge. In this study, we present a novel microchip based on liquid crystals for assessing the surface charge distribution of a planar or soft surface. This chip enables rapid measurements of the local surface charge distribution of a charged surface. The chip consists of a micropillar array fabricated on a transparent indium tin oxide substrate, while the liquid crystal is used to fill in the gaps between the micropillar structures. When an object is placed on top of the chip, the local surface charge (or zeta potential) influences the orientation of the liquid crystal molecules, resulting in changes in the magnitude of transmitted light. By measuring the intensity of the transmitted light, the distribution of the surface charge can be accurately quantified. We calibrated the chip in a three-electrode configuration and demonstrated the validity of the chip for rapid surface charge mapping using a borosilicate glass slide. This chip offers noninvasive, rapid mapping of surface charges on charged surfaces, with no need for physical or chemical modifications, and has broad potential applications in biomedical research and advanced material design. Full article

Background: Troponin I and T are biomarkers to diagnose myocardial infarction and damage. Studies indicate that strenuous physical activity can cause transient increases in these troponin levels, typically considered physiological. However, current data show differences in the exercise-induced increase in troponin I and T in elite athletes. Method: This prospective clinical study aimed to determine troponin I and T levels in 36 top cross-country skiers of the German national team (18 male, 18 female) after a standardized competition load over two days. All study participants underwent a comprehensive sports medical and cardiological evaluation, including ECG and echocardiography. A multivariable regression analysis was utilized to identify possible predictors of increased troponin I levels. Results: Only three male athletes (8.1%) showed an isolated increase in Troponin I (Ø 112.49 ng/L, cut off < 45.2 ng/L), while no increase in troponin T in the study population was detected. Conclusions: The analysis suggested several potential predictors for increased troponin I levels, such as height, weight, weekly training hours, and indications of an enlarged sports heart, though none achieved statistical significance. Knowing the different exercise-induced detectability of the various troponins in the clinical setting is essential. Full article

Tiny person detection based on computer vision technology is critical for maritime emergency rescue. However, humans appear very small on the vast sea surface, and this poses a huge challenge in identifying them. In this study, a single-stage tiny person detector, namely the “You only look once”-based Maritime Tiny Person detector (MTP-YOLO), is proposed for detecting maritime tiny persons. Specifically, we designed the cross-stage partial layer with two convolutions Efficient Layer Aggregation Networks (C2fELAN) by drawing on the Generalized Efficient Layer Aggregation Networks (GELAN) of the latest YOLOv9, which preserves the key features of a tiny person during the calculations. Meanwhile, in order to accurately detect tiny persons in complex backgrounds, we adopted a Multi-level Cascaded Enhanced Convolutional Block Attention Module (MCE-CBAM) to make the network attach importance to the area where the object is located. Finally, by analyzing the sensitivity of tiny objects to position and scale deviation, we proposed a new object position regression cost function called Weighted Efficient Intersection over Union (W-EIoU) Loss. We verified our proposed MTP-YOLO on the TinyPersonv2 dataset. All these results confirm that this method significantly improves model performance while maintaining a low number of parameters and can therefore be applied to maritime emergency rescue missions. Full article

Northeast China’s sandy region is an arid and semi-arid zone highly susceptible to climate change. Investigating the long-term changes in the Northeast China sandy land (Northeast China sandy land, DBSL) landscape can provide an important basis for the ecological restoration of this region. This study analyzed long-term remote sensing data of the DBSL from 1980 to 2022 and explored the spatial pattern, evolution, and driving mechanisms. In 2022, vegetation was mainly distributed in the northwest, center, and southwest, covering a total area of 30,508.82 km². Areas with high and medium vegetation cover showed strong aggregation characteristics and were mainly distributed in the southwest, whereas those with low vegetation coverage were highly dispersed and widely distributed in the central region. Lakes were widely distributed in the northwest and central regions, with a total area of 2736.43 km². In the last 42 years, the vegetation cover decreased by 24.48%. Areas with high and medium vegetation coverage decreased in size, and those with low vegetation coverage first increased and then decreased, with overall decreases of 35.35%, 19.16%, and 6.88%, respectively. The overall area of the DBSL showed various degrees of degradation. Shrinking and dry lakes were concentrated in the sandy hinterland. The lake landscape changed significantly from 1990 to 2010, with a decrease in lake area of 27.41%. In contrast, the sandy area increased by 25.65%, indicating a high degree of desertification. However, from 2005 to 2022, desertification decelerated. The most important factors driving the evolution of the DBSL were socio-economic factors. The increase in human disturbance will have a certain impact on the landscape changes in the region in the short term. The national policy of returning farmland to fields and grasslands will affect the increase of vegetation and lake landscape area in the short term, and the sand area and excessive animal husbandry will be reduced. This study provides a scientific basis for ecological restoration and sustainable development in Northeast China. Full article

The proliferation of new technologies and advancements in existing ones are altering our perspective of the world. So, continuous improvements are needed. A connected world filled with a vast amount of data was created as a result of the integration of these advanced technologies in the financial sector. The advantages of this connection came at the cost of more sophisticated and advanced attacks, such as fraudulent transactions. To address these illegal transactions, researchers and engineers have created and implemented various systems and models to detect fraudulent transactions; many of them produce better results than others. On the other hand, criminals change their strategies and technologies to imitate legitimate transactions. In this article, the objective is to propose an intelligent system for detecting fraudulent transactions using various deep learning architectures, including artificial neural networks (ANNs), recurrent neural networks (RNNs), and long short-term memory (LSTM). Furthermore, the Bayesian optimization algorithm is used for hyperparameter optimization. For the evaluation, a credit card fraudulent transaction dataset was used. Based on the many experiments conducted, the RNN architecture demonstrated better efficiency and yielded better results in a shorter computational time than the ANN LSTM architectures. Full article

The increasing demand for deep excavations in construction projects emphasizes the necessity of robust support structures to ensure safety and stability. Support structures are critical in stabilizing excavation pits, with a primary focus on enhancing their bearing capacity. This paper employs finite element modeling techniques to conduct a numerical analysis of nails and helical anchors’ bearing capacity. To reinforce the stability of pit walls, selecting an appropriate method for guard structure construction is imperative. The chosen method should efficiently redistribute forces induced by soil mass weight, displacements, and potential loads in the pit vicinity to the ground. Various techniques, including trusses, piles, cross-bracing systems, nailing, and anchorage systems, are utilized for this purpose. The study evaluates numerical models for two guard structure configurations: nailing systems and helical anchorage. It examines the impact of parameters such as displacement, helical helix count, helix diameter variations, and the integration of nailing systems with helices. Comparative analyses are conducted, including displacement comparisons between different nailing systems and helical anchor systems, along with laboratory-sampled data. The research yields significant insights, with a notable finding highlighting the superior performance of helical bracings compared to nailing systems. The conclusions drawn from this study provide specific outcomes that contribute valuable knowledge to the field of deep excavation support structures, guiding future design and implementation practices. Full article

Spatial perception plays a critical role in virtual worlds and real environments, as it can impact navigation abilities. To understand this influence, the conducted study investigated the effects of human characteristics and immersion levels on the exocentric distance estimation process in virtual environments. As the first step, a virtual environment was implemented for both desktop and Gear VR head-mounted displays. Afterward, the exocentric distance estimation skills of 229 university students were examined. Out of these students, 157 used the desktop display, and 72 used the Gear VR. Using logistic regression analysis and linear regression analysis methods, their effects on the probabilities of accurate estimates and their estimation times were investigated. According to the results, gender, video game playtime per week, height, and display device had significant effects on the former, whereas dominant hand, video game playtime per week, height, and display device had significant effects on the latter. The results also show that by using the head-mounted display, the likelihood of the students estimating exocentric distances accurately significantly decreased; however, they were significantly faster with it. These findings can influence the development of more accessible and effective virtual environments in the future. Full article

The aim of this study was to assess surgical treatment in metacarpal shaft fractures of the second to fifth ray to determine the functional outcomes and complications in open reduction and internal fixation (ORIF) versus closed reduction and internal fixation (CRIF). This was a retrospective study that included patients with metacarpal shaft fractures of the second to fifth rays who were treated surgically between 1 January 2007 and 31 December 2019. Functional outcomes were scored using the QuickDASH and Eq5D score. A total of 231 treated patients were included. Single fractures were seen in 180 patients, and multiple fractures in 51 patients. ORIF was applied in 141 patients and CRIF in 90 patients. The functional outcomes were not significantly different between the groups. Complications were found in 41 (29%) of the ORIF patients and 15 (17%) of the CRIF patients. The functional outcomes after single or multiple metacarpal shaft fractures were similar in the ORIF and CRIF patients. ORIF showed significantly more complications, such as functional impairment and infections and a higher reoperation rate. In conclusion, CRIF is as safe as ORIF for the surgical treatment of metacarpal shaft fractures in terms of its functional outcome and slightly preferable due to its lower complication rate. Full article

Antibody responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are multi-targeted and variable over time. Multiplex quantitative serological assays are needed to provide accurate and robust seropositivity data for the establishment of serological signatures during vaccination and or infection. We describe here the validation and evaluation of an electro-chemiluminescence (ECL)-based Mesoscale Discovery assay (MSD) for estimation of total and functional IgG relative to SARS-CoV-2 spike, nucleocapsid and receptor binding (RBD) proteins in human serum samples to establish serological signatures of SARS-CoV-2 natural infection and breakthrough cases. The 9-PLEX assay was validated as per ICH, EMA, and US FDA guidelines using a panel of sera samples, including the NIBSC/WHO reference panel (20/268). The assay demonstrated high specificity and selectivity in inhibition assays, wherein the homologous inhibition was more than 85% and heterologous inhibition was below 10%. The assay also met predetermined acceptance criteria for precision (CV < 20%), accuracy (70–130%) and dilutional linearity. The method’s applicability to serological signatures was demonstrated using sera samples (n = 45) representing vaccinated, infected and breakthrough cases. The method was able to establish distinct serological signatures and thus provide a potential tool for seroprevalence of SARS-CoV-2 during vaccination or infection. Full article

While typically exhibiting characteristic features, fungal infections can sometimes present in an unusual context, having improbable localization (eyelid, face, or joint); mimicking other skin diseases such as eczema, psoriasis, or mycosis fungoides; and appearing with unexpected color, shape, or distribution. The emergence of such a challenging clinical picture is attributed to the complex interplay of host characteristics (hygiene and aging population), environment (climate change), advances in medical procedures, and agent factors (fungal resistance and species emergence). We aim to provide a better understanding of unusual epidemiological contexts and atypical manifestations of fungal superficial diseases, knowing that there is no pre-established clinical guide for these conditions. Thus, a literature examination was performed to provide a comprehensive analysis on rare and atypical superficial mycosis as well as an update on certain fungal clinical manifestations and their significance. The research and standard data extraction were performed using PubMed, Medline, Scopus, and EMBASE databases, and a total of 222 articles were identified. This review covers published research findings for the past six months. Full article

The burgeoning complexity and heterogeneity of IoT networks, coupled with their rapid growth, constant evolution, and new players, present significant challenges in terms of connectivity, interoperability, management, and usability. These networks, composed of a diverse array of devices, technologies and the like, demand innovative solutions to bridge the gaps between different IoT technologies and communication protocols. This article presents a simple, yet efficacious communication Relay to address one of these critical gaps. This Relay uses NB-IoT to ease the integration of 6LoWPAN-based IoT devices (IPv6) into the public legacy Internet (IPv4). This device translates 6LoWPAN, IPv6 CoAP messages into Internet-standard REST requests, so that appropriate handling of devices’ data be achieved in several stages. Thus, the Relay establishes two branches of communications: (i) the local network where the 6LoWPAN gateway is placed, and (ii) the public NB-IoT network. User interaction and data analysis are achieved by virtue of Home Assistant, where former 6LoWPAN devices are now discovered and shown as proper Home Assistant entities thanks to the Relay’s ease of integration into the open-source platform. This novel approach not only ensures efficient data and network management, but it also meets the urgent necessity for advanced solutions in enhancing actual IoT interconnectivity and monitoring. The unprecedented pace at which IoT devices, players and different networks have been proliferating in recent times is not compatible with countless manufacturer-dependent platforms, applications, and proprietary protocols that the IoT field has been leading with so far, almost from its beginnings. Full article

Decades of research has revealed a relationship between childhood socioeconomic status (SES) and brain development at the structural and functional levels. Of particular note is the distinction between income and maternal education, two highly correlated factors which seem to influence brain development through distinct pathways. Specifically, while a families’ income-to-needs ratio is linked with physiological stress and household chaos, caregiver education influences the day-to-day language environment a child is exposed to. Variability in either one of these environmental experiences is related to subsequent brain development. While this work has the potential to inform public policies in a way that benefits children, it can also oversimplify complex factors, unjustly blame low-SES parents, and perpetuate a harmful deficit perspective. To counteract these shortcomings, researchers must consider sociodemographic differences in the broader cultural context that underlie SES-based differences in brain development. This review aims to address these issues by (a) identifying how sociodemographic mechanisms associated with SES influence the day-to-day experiences of children, in turn, impacting brain development, while (b) considering the broader cultural contexts that may differentially impact this relationship. Full article

In this study, composite particles of rGO/CoFe₂O₄ were synthesized using a solvothermal method to fabricate a low-density magnetorheological (MR) material with enhanced sedimentation stability. The morphology and crystallographic features of rGO/CoFe₂O₄ were characterized via SEM, TEM, and XRD, and its magnetic properties were tested using VSM. The MR fluid was formulated by blending rGO/CoFe₂O₄ particles into silicone oil. Under different magnet strengths (H), a rotational rheometer was used to test its MR properties. Typical MR properties were observed, including shear stress, viscosity, storage/loss modulus, and dynamic yield stress (${\tau }_{dy}$) following the Herschel–Bulkley model reaching 200 Pa when H is 342 kA/m. Furthermore, the yield stress of the MR fluid follows a power law relation as H increases and the index changes from 2.0 (in the low H region) to 1.5 (in the high H region). Finally, its MR efficiency was calculated to be about 10⁴% at H of 342 kA/m. Full article

COVID-19 is a lung disease caused by a coronavirus family virus. Due to its extraordinary prevalence and associated death rates, it has spread quickly to every country in the world. Thus, achieving peaks and outlines and curing different types of relapses is extremely important. Given the worldwide prevalence of coronavirus and the participation of physicians in all countries, information has been gathered regarding the properties of the virus, its diverse types, and the means of analyzing it. Numerous approaches have been used to identify this evolving virus. It is generally considered the most accurate and acceptable method of examining the patient’s lungs and chest through a CT scan. As part of the feature extraction process, a method known as fractional Fourier transform (FrFT) has been applied as one of the time-frequency domain transformations. The proposed method was applied to a database consisting of 2481 CT images. Following the transformation of all images into equal sizes and the removal of non-lung areas, multiple combination windows are used to reduce the number of features extracted from the images. In this paper, the results obtained for KNN and SVM classification have been obtained with accuracy values of 99.84% and 99.90%, respectively. Full article

In recent years, the incidence of fungal infections in humans has increased dramatically, accompanied by an expansion in the number of species implicated as etiological agents, especially environmental fungi never involved before in human infection. Among fungal pathogens, Candida species are the most common opportunistic fungi that can cause local and systemic infections, especially in immunocompromised individuals. Candida albicans (C. albicans) is the most common causative agent of mucosal and healthcare-associated systemic infections. However, during recent decades, there has been a worrying increase in the number of emerging multi-drug-resistant non-albicans Candida (NAC) species, i.e., C. glabrata, C. parapsilosis, C. tropicalis, C. krusei, C. auris, and C. ciferrii. In particular, Candida ciferrii, also known as Stephanoascus ciferrii or Trichomonascus ciferrii, is a heterothallic ascomycete yeast-like fungus that has received attention in recent decades as a cause of local and systemic fungal diseases. Today, the new definition of the S. ciferrii complex, which consists of S. ciferrii, Candida allociferrii, and Candida mucifera, was proposed after sequencing the 18S rRNA gene. Currently, the S. ciferrii complex is mostly associated with non-severe ear and eye infections, although a few cases of severe candidemia have been reported in immunocompromised individuals. Low susceptibility to currently available antifungal drugs is a rising concern, especially in NAC species. In this regard, a high rate of resistance to azoles and more recently also to echinocandins has emerged in the S. ciferrii complex. This review focuses on epidemiological, biological, and clinical aspects of the S. ciferrii complex, including its pathogenicity and drug resistance. Full article

The tumor-to-stroma ratio is a highly debated prognostic factor in the management of several solid tumors and there is no universal agreement on its practicality. In our study, we proposed confirming or dismissing the hypothesis that a simple measurement of stroma quantity is an easy-to-use and strong prognostic tool. We have included 74 consecutive patients with colorectal cancer who underwent primary curative abdominal surgery. The tumors have been grouped into stroma-poor (stroma < 10%), medium-stroma (between 10 and 50%) and stroma-rich (over 50%). The proportion of tumor stroma ranged from 5% to 70% with a median of 25%. Very few, only 6.8% of patients, had stroma-rich tumors, 4% had stroma-poor tumors and 89.2% had tumors with a medium quantity of stroma. The proportion of stroma, at any cut-off, had no statistically significant influence on the disease-specific survival. This can be explained by the low proportion of stroma-rich tumors in our patient group and the inverse correlation between stroma proportion and tumor grade. The real-life proportion of stroma-rich tumors and the complex nature of the stroma–tumor interaction has to be further elucidated. Full article

Context: Psychological distress symptoms in the last days of life often contribute to the overall symptom burden in frail older patients. Good symptom management practices are crucial to ensure high-quality end-of-life care in an aging population, though the best pharmacological approach to treat these psychological symptoms has yet to be established. Objectives: To identify current evidence-based and practice-based knowledge of pharmacological interventions for the treatment of agitation, delirium, and anxiety during the last days of life in frail older patients. Methods: A systematic, mixed methods review was performed through MEDLINE via PubMed and EMBASE from inception until February 2022 and updated through March 2023. National and international guideline databases and grey literature were searched for additional studies and guidelines. Results: Four quantitative studies, two non-randomized and two descriptive, were identified. No randomized controlled trials met inclusion criteria. No qualitative studies were withheld. The three consensus-based protocols that were found through citation searching and screening of grey literature did not meet the standards for inclusion. Haloperidol is recommended in consensus-based guidelines for delirium and is widely used, but high-quality evidence about its efficacy is missing. Better control of agitation or refractory delirium might be achieved with the addition of a benzodiazepine. There is no evidence available about the treatment of anxiety in the last days of life in frail older patients. Conclusions: This mixed methods review demonstrates the lack of good quality evidence that is needed to help clinicians with pharmacological treatment decisions when confronted with psychological symptoms in the last days of life in frail older patients. Population aging will only emphasize the need for further research in this specific population. Full article

Liver cancer is the second leading cause of cancer-related death in males. It is estimated that approximately one million deaths will occur by 2030 due to hepatic cancer. Hepatocellular carcinoma (HCC) is the most prevalent primary liver cancer subtype and is commonly diagnosed at an advanced stage. The drug arsenal used in systemic therapy for HCC is very limited. Multikinase inhibitors sorafenib (Nexavar^®) and lenvatinib (Lenvima^®) have been used as first-line drugs with modest therapeutic effects. In this scenario, it is imperative to search for new therapeutic strategies for HCC. Herein, the antiproliferative activity of N-acylhydrazone derivatives was evaluated on HCC cells (HepG2 and Hep3B), which were chemically planned on the ALL-993 scaffold, a potent inhibitor of vascular endothelial growth factor 2 (VEGFR2). The substances efficiently reduced the viability of HCC cells, and the LASSBio-2052 derivative was the most effective. Further, we demonstrated that LASSBio-2052 treatment induced FOXM1 downregulation, which compromises the transcriptional activation of genes required for G2/M transition, such as AURKA and AURKB, PLK1, and CDK1. In addition, LASSBio-2052 significantly reduced CCNB1 and CCND1 expression in HCC cells. Our findings indicate that LASSBio-2052 is a promising prototype for further in vivo studies. Full article

The importance of spirituality in the treatment of mental illness is increasingly acknowledged, but mental healthcare professionals often feel they lack specific competence. An instrument is missing to quantify the spiritual care competence of mental healthcare professionals in the Netherlands. The aim of this study was thus to translate the Spiritual Care Competence Questionnaire (SCCQ) into Dutch and validate it for use in mental healthcare. After translation, the SCCQ-NL was distributed in a cross-sectional design among 3497 healthcare professionals in two mental healthcare institutions (MHIs) in the Netherlands. In the sample of 730 completed questionnaires, exploratory factor analysis revealed seven factors: perception of spiritual needs competencies, team spirit, spiritual self-awareness, documentation competencies, empowerment and proactive opening competencies, knowledge about other religions, and conversation competencies. One item was deleted during the process. Internal consistency for the 25-item SCCQ-NL subscales is sufficient with Cronbach’s alpha ranging from 0.64 to 0.81. Conversation competencies and perception of spiritual needs scored highest in the sample, next to knowledge about other religions and empowerment competencies, while spiritual self-awareness, team spirit and documentation competencies scored the lowest. Small but significant differences in several subscale scores were found for profession, identifying oneself as a believer, practicing prayer and/or meditation, age and working years. The SCCQ-NL can be used for the assessment of spiritual care competencies and for the planning and evaluation of training and improvement strategies. Full article

The influenza A(H1N1) pdm09 virus, which emerged in 2009, has been circulating seasonally since then. In this study, we conducted a comprehensive genome-based investigation to gain a detailed understanding of the genetic and evolutionary characteristics of the hemagglutinin (HA) and neuraminidase (NA) surface proteins of A/H1N1pdm09 strains circulating in Italy over a fourteen-year period from 2009 to 2023 in relation to global strains. Phylogenetic analysis revealed rapid transmission and diversification of viral variants during the early pandemic that clustered in clade 6B.1. In contrast, limited genetic diversity was observed during the 2023 season, probably due to the genetic drift, which provides the virus with a constant adaptability to the host; furthermore, all isolates were split into two main groups representing two clades, i.e., 6B.1A.5a.2a and its descendant 6B.1A.5a.2a.1. The HA gene showed a faster rate of evolution compared to the NA gene. Using FUBAR, we identified positively selected sites 41 and 177 for HA and 248, 286, and 455 for NA in 2009, as well as sites 22, 123, and 513 for HA and 339 for NA in 2023, all of which may be important sites related to the host immune response. Changes in glycosylation acquisition/loss at prominent sites, i.e., 177 in HA and 248 in NA, should be considered as a predictive tool for early warning signs of emerging pandemics, and for vaccine and drug development. Full article