The 2023 MDPI Annual Report has
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Article
Naïve Inflammatory Proteome Profiles of Glucocorticoid Responsive Polymyalgia Rheumatica and Rheumatic Arthritis Patients—Links to Triggers and Proteomic Manifestations
by Allan Stensballe, Jacob Skallerup Andersen, Christopher Aboo, Anders Borg Andersen, Jie Ren, Michael Kruse Meyer, Kate Lykke Lambertsen and Peter Derek Christian Leutscher
J. Pers. Med. 2024, 14(5), 449; https://doi.org/10.3390/jpm14050449 (registering DOI) - 25 Apr 2024
Abstract
Polymyalgia rheumatica (PMR) is an inflammatory disorder of unknown etiology, sharing symptoms with giant cell arthritis (GCA) and rheumatoid arthritis (RA). The pathogenic inflammatory roots are still not well understood, and there is a lack of extensive biomarker studies to explain the disease [...] Read more.
Polymyalgia rheumatica (PMR) is an inflammatory disorder of unknown etiology, sharing symptoms with giant cell arthritis (GCA) and rheumatoid arthritis (RA). The pathogenic inflammatory roots are still not well understood, and there is a lack of extensive biomarker studies to explain the disease debut and post-acute phase. This study aimed to deeply analyze the serum proteome and inflammatory response of PMR patients before and after glucocorticoid treatment. We included treatment-naïve PMR patients, collecting samples before and after 3 months of treatment. For comparison, disease-modifying antirheumatic drug (DMARD)-naïve RA patients were included and matched to healthy controls (CTL). The serum proteome was examined using label-free quantitative mass spectrometry, while inflammation levels were assessed using multiplex inflammatory cytokine and cell-free DNA assays. The serum proteomes of the four groups comprised acute phase reactants, coagulation factors, complement proteins, immunoglobulins, and apolipoproteins. Serum amyloid A (SAA1) was significantly reduced by active PMR treatment. Cell-free DNA levels in PMR and RA groups were significantly higher than in healthy controls due to acute inflammation. Complement factors had minimal changes post-treatment. The individual serum proteome in PMR patients showed over 100 abundantly variable proteins, emphasizing the systemic impact of PMR disease debut and the effect of treatment. Interleukin (IL)-6 and interferon-gamma (IFN-γ) were significantly impacted by glucocorticoid treatment. Our study defines the PMR serum proteome during glucocorticoid treatment and highlights the role of SAA1, IL-6, and IFN-γ in treatment responses. An involvement of PGLYRP2 in acute PMR could indicate a response to bacterial infection, highlighting its role in the acute phase of the immune response. The results suggest that PMR may be an aberrant response to a bacterial infection with an exacerbated IL-6 and acute phase inflammatory response and molecular attempts to limit the inflammation. Full article
14 pages, 14550 KiB  
Technical Note
Fluctuations in Refracted Star Signals Caused by the Stratospheric Internal Gravity Waves
by Shaochong Wu, Hongyuan Wang, Xunjiang Zheng and Zhiqiang Yan
Remote Sens. 2024, 16(9), 1519; https://doi.org/10.3390/rs16091519 (registering DOI) - 25 Apr 2024
Abstract
The application of starlight refraction navigation to spacecraft and space weapons is a significant development. However, the irregular stratospheric atmosphere can cause fluctuations in relative light intensity and refraction angles of refracted stars, which need to be analyzed to provide guidance for system [...] Read more.
The application of starlight refraction navigation to spacecraft and space weapons is a significant development. However, the irregular stratospheric atmosphere can cause fluctuations in relative light intensity and refraction angles of refracted stars, which need to be analyzed to provide guidance for system design and simulation verification. The internal gravity wave (IGW) is an important component of the irregular atmosphere. Based on the Rytov approximation, closed-form approximations were obtained, which can more intuitively reveal the relationship between the IGW parameters and the star signals’ statistical characteristics. From the GOMOS observations, the influence of the stratosphere from 25 km to 35 km on the fluctuations in relative intensity and refraction angles was analyzed in this study. As the height increased, the fluctuations in starlight signals gradually weakened. Compared with the numerical solution, the error of the closed-form approximations for relative intensity fluctuations was no more than 10%, and the error for refraction angle fluctuations was 1.0%. Compared with the measured data, the error of the closed-form approximations for relative intensity was 6.3%. The proposed approximations better reflect the relationship between IGW parameters and star signal fluctuations compared to the existing approximation. The research in this article can provide a reference for application assessment based on starlight refraction navigation. Full article
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11 pages, 44177 KiB  
Communication
Shifting Mountain Tree Line Increases Soil Organic Carbon Stability Regardless of Land Use
by Sofia Sushko, Kristina Ivashchenko, Alexandra Komarova, Anna Yudina, Victoria Makhantseva, Ekaterina Elsukova and Sergey Blagodatsky
Plants 2024, 13(9), 1193; https://doi.org/10.3390/plants13091193 (registering DOI) - 25 Apr 2024
Abstract
Climate and land use changes are causing trees line to shift up into mountain meadows. The effect of this vegetation change on the partitioning of soil carbon (C) between the labile particulate organic matter (POM–C) and stable mineral-associated organic matter (MAOM–C) pools is [...] Read more.
Climate and land use changes are causing trees line to shift up into mountain meadows. The effect of this vegetation change on the partitioning of soil carbon (C) between the labile particulate organic matter (POM–C) and stable mineral-associated organic matter (MAOM–C) pools is poorly understood. Therefore, we assessed these C pools in a 10 cm topsoil layer along forest–meadow ecotones with different land uses (reserve and pasture) in the Northwest Caucasus of Russia using the size fractionation technique (POM 0.053–2.00 mm, MAOM < 0.053 mm). Potential drivers included the amount of C input from aboveground grass biomass (AGB) and forest litter (litter quantity) and their C/N ratios, aromatic compound content (litter quality), and soil texture. For both land uses, the POM–C pool showed no clear patterns of change along forest–meadow ecotones, while the MAOM–C pool increased steadily from meadow to forest. Regardless of land use, the POM–C/MAOM–C ratio decreased threefold from meadow to forest in line with decreasing grass AGB (R2 = 0.75 and 0.29 for reserve and pasture) and increasing clay content (R2 = 0.63 and 0.36 for reserve and pasture). In pastures, an additional negative relationship was found with respect to plant litter aromaticity (R2 = 0.48). Therefore, shifting the mountain tree line in temperate climates could have a positive effect on conserving soil C stocks by increasing the proportion of stable C pools. Full article
(This article belongs to the Topic Plant-Soil Interactions, 2nd Volume)
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14 pages, 1187 KiB  
Article
An Assessment of the Suitability of Contrasting Biosolids for Raising Indigenous Plants in Nurseries
by Claudia Garcés-Hernández, Brett Robinson, Claudio Bravo-Linares, Hamish Lowe, Seinalyn Villanueva, Jennifer Prosser and María-Jesús Gutiérrez-Ginés
Water 2024, 16(9), 1226; https://doi.org/10.3390/w16091226 (registering DOI) - 25 Apr 2024
Abstract
Disposal of biosolids, the solid fraction of sewage treatment, is a global environmental issue. Biosolids contain valuable organic matter and plant nutrients; however, they also contain contaminants including trace elements, xenobiotics, and pathogens. The quality of the biosolids greatly depends on the source [...] Read more.
Disposal of biosolids, the solid fraction of sewage treatment, is a global environmental issue. Biosolids contain valuable organic matter and plant nutrients; however, they also contain contaminants including trace elements, xenobiotics, and pathogens. The quality of the biosolids greatly depends on the source of wastewater (i.e., industrial vs. domestic) and the treatment processes. We aimed to determine the potential of three distinct biosolids and one pond sludge to grow indigenous plants for ecosystem restoration. For each amendment, we tested six indigenous species, Veronica salicifolia, Corokia cheesemanii, Griselinia littoralis, Phormium tenax, Poa cita, and Cordyline australis in bark mixed with biosolids and/or pond sludge at rates of 0–50%. There was a significant positive correlation between plant growth and biosolid addition up to a species-dependent plateau. Growth decreased at the highest rates. At a rate of 10% for fresh biosolids and 30% for aged biosolids provided consistent optimal growth across all species. The pond sludge was unsuitable for the establishment of indigenous seedlings. At the optimal rates, there were significant increases in foliar N, P, K, S, and Zn. None of the trace elements accumulated in the plants at phytotoxic concentrations or levels that presented a risk to ecosystems. Future work should determine how plants raised with biosolids perform once planted out in the field. Full article
(This article belongs to the Special Issue Sewage Sludge: Treatment and Recovery)
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13 pages, 432 KiB  
Article
The Impact of Financial Development on Renewable Energy Consumption: The Case of Vietnam and Other ASEAN Members
by Chien Van Nguyen
Int. J. Financial Stud. 2024, 12(2), 37; https://doi.org/10.3390/ijfs12020037 (registering DOI) - 25 Apr 2024
Abstract
The purpose of this study was to evaluate the impact of financial development and renewable energy consumption in Vietnam and some selected countries in Southeast Asia. After researching over the period from 1970 to 2022, using quantitative analyses, including the ordinary least squares [...] Read more.
The purpose of this study was to evaluate the impact of financial development and renewable energy consumption in Vietnam and some selected countries in Southeast Asia. After researching over the period from 1970 to 2022, using quantitative analyses, including the ordinary least squares (OLS), fixed effects method (FEM), and random effects method (REM), and measuring the Driscoll–Kraay standard errors to assess cross-dependence between countries as well as a Dynamic Ordinary Least Squares (DOLS) estimation analysis to evaluate the robustness of the research, the research results confirm that financial development has a negative impact on renewable energy consumption, which reflects the important role of fossil energy sources in meeting energy consumption demand. Similarly, increased per capita income negatively affects renewable energy consumption. This study also confirms the positive impact of foreign direct investment on renewable energy use. Full article
(This article belongs to the Special Issue Sustainable Investing and Financial Services)
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17 pages, 9542 KiB  
Article
Nectar Production and Three Main Sugars in Nectar of Salvia pratensis and Salvia glutinosa in Correlation with Abiotic Factors
by Katja Malovrh, Blanka Ravnjak, Jože Bavcon and Mitja Križman
Agriculture 2024, 14(5), 668; https://doi.org/10.3390/agriculture14050668 (registering DOI) - 25 Apr 2024
Abstract
Floral nectar is mainly a reward in the form of food for pollinators. Its composition plays an important role when pollinators choose their food. Several studies have shown that the popularity of flowers with nectar is influenced by the concentration and ratio of [...] Read more.
Floral nectar is mainly a reward in the form of food for pollinators. Its composition plays an important role when pollinators choose their food. Several studies have shown that the popularity of flowers with nectar is influenced by the concentration and ratio of sugars. Here, we present the nectar chemical composition with regard to three main sugars and their concentrations in correlation with abiotic factors for the plant species Salvia pratensis L. and Salvia glutinosa L. through their 2023 flowering season. We sampled nectar using microcapillaries at three different times during the day on sites in nature. Our results show that nectar production in both species is the highest at around 12 a.m. The abiotic factor that affects nectar production in both species is the soil temperature, while UVB radiation does not influence nectar production. Air temperature and air humidity affect the nectar production of S. glutinosa, while soil humidity affects nectar production in S. pratensis. The most represented sugar in S. glutinosa nectar is sucrose, while S. pratensis nectar has more glucose and fructose. Our results show that UVB radiation has an effect on the sucrose level, although it does not have any direct effect on nectar productivity. Full article
(This article belongs to the Section Agricultural Product Quality and Safety)
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17 pages, 7366 KiB  
Article
Simulation Analysis and Experimental Study on the Fluid–Solid–Thermal Coupling of Traction Motor Bearings
by Hengdi Wang, Han Li, Zheming Jin, Jiang Lin, Yongcun Cui, Chang Li, Heng Tian and Zhiwei Wang
Lubricants 2024, 12(5), 144; https://doi.org/10.3390/lubricants12050144 (registering DOI) - 25 Apr 2024
Abstract
The traction motor is a crucial component of high-speed electric multiple units, and its operational reliability is directly impacted by the temperature increase in the bearings. To accurately predict and simulate the temperature change process of traction motor bearings during operation, a fluid–solid–thermal [...] Read more.
The traction motor is a crucial component of high-speed electric multiple units, and its operational reliability is directly impacted by the temperature increase in the bearings. To accurately predict and simulate the temperature change process of traction motor bearings during operation, a fluid–solid–thermal simulation analysis model of grease-lubricated deep groove ball bearings was constructed. This model aimed to simulate the temperature rise of the bearing and the grease flow process, which was validated through experiments. The results from the simulation analysis and tests indicate that the temperature in the contact zone between the bearing rolling element and the raceway, as well as the ring temperature, initially increases to a peak and then gradually decreases, eventually stabilizing once the bearing’s heat generation power and heat transfer power reach equilibrium. Furthermore, the established fluid–solid–thermal coupling simulation analysis model can accurately predict the amount of grease required for effective lubrication in the bearing cavity, which stabilizes along with the bearing temperature. The findings of this research can serve as a theoretical foundation and technical support for monitoring the health status of high-speed EMU traction motor bearings. Full article
(This article belongs to the Special Issue Tribological Characteristics of Bearing System, 2nd Edition)
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20 pages, 4384 KiB  
Article
Finite-Time Attitude Control of Quadrotor Unmanned Aerial Vehicle with Disturbance and Actuator Saturation
by Zheng Zhang, Xingwei Li and Lilian Zhang
Appl. Sci. 2024, 14(9), 3639; https://doi.org/10.3390/app14093639 (registering DOI) - 25 Apr 2024
Abstract
This paper introduces a nonlinear dynamic inversion control algorithm designed to address unknown disturbances and actuator saturation issues in unmanned aerial vehicle (UAV) attitude control. The algorithm is based on a combination of finite-time disturbance observer and anti-saturation auxiliary system, which ensures the [...] Read more.
This paper introduces a nonlinear dynamic inversion control algorithm designed to address unknown disturbances and actuator saturation issues in unmanned aerial vehicle (UAV) attitude control. The algorithm is based on a combination of finite-time disturbance observer and anti-saturation auxiliary system, which ensures the rapid convergence of attitude tracking error. Firstly, based on the Newton–Euler equations, this paper establishes a model of the attitude system for quadrotor UAVs, and this paper eliminates the small-angle flight assumption. Secondly, considering the actuator saturation problem, an anti-saturation auxiliary control system is designed to shorten the time when the control volume is in the saturation interval and achieve finite-time convergence of the attitude error. And then, to improve the robustness of the controller, this paper proposes a disturbance observer based on the finite-time stability theory, which achieves a continuous smooth output of the observation results by introducing a hyperbolic tangent function in the observer, so that the observation error can be converged to zero in a finite time. Finally, it is demonstrated by Simulink simulation that the attitude error and the observation error converge quickly to zero. Full article
(This article belongs to the Section Aerospace Science and Engineering)
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14 pages, 2396 KiB  
Article
MdSGR2 Negatively Regulates Chlorophyll Degradation in Apple
by Shiyi Xue, Pei Yao, Jiwei Kang, Xiong Zheng, Chang Liu, Yan Gao, Dehui Zhang, Xiaojun Zhang and Yanyan Hao
Horticulturae 2024, 10(5), 439; https://doi.org/10.3390/horticulturae10050439 (registering DOI) - 25 Apr 2024
Abstract
The color of an apple is an important index of its appearance quality, which affects the fruit’s marketability and value. The green variety “Granny Smith” remains green when ripe, and the pigment in the peel is mainly chlorophyll. The chlorophyll in the peel [...] Read more.
The color of an apple is an important index of its appearance quality, which affects the fruit’s marketability and value. The green variety “Granny Smith” remains green when ripe, and the pigment in the peel is mainly chlorophyll. The chlorophyll in the peel of the yellow variety “Golden Delicious” degrades as the fruit ripens. To explore the different mechanisms of chlorophyll degradation in the “Golden Delicious” and “Granny Smith” varieties, transcriptomic analysis was performed on the mature peels of both cultivars. High-quality sequences totaling 48,206,940 and 48,796,646 raw bases, as well as 9632 differentially expressed genes (DEGs), were identified. A total of 1206 DEGs were classified in 118 KEGG metabolic pathways. Additionally, 3258 transcription factors from 428 gene families were predicted, and DEGs associated with chlorophyll degradation, including MdSGR2, MdNYC1 and MdHCAR, were identified. Subsequently, the MdSGR2 gene was isolated from the mature peel of “Granny Smith” apples. Subsequent subcellular localization analysis confirmed that MdSGR2 specifically targets chloroplasts. The transient overexpression of MdSGR2 was found to negatively regulate chlorophyll degradation, leading to the inhibition or deceleration of chlorophyll breakdown, thereby maintaining green coloration in the leaves and peel. Conversely, silencing MdSGR2 positively regulated chlorophyll degradation, resulting in chlorosis in the leaves and peel. These findings offer valuable insights into the regulatory mechanism governing apple fruit coloration and lays a solid foundation for further investigation in this field. Full article
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15 pages, 2431 KiB  
Article
3-Ethynyltriimidazo[1,2-a:1′,2′-c:1″,2″-e][1,3,5]triazine Dual Short- and Long-Lived Emissions with Crystallization-Enhanced Feature: Role of Hydrogen Bonds and π-π Interactions
by Daniele Malpicci, Daniele Maver, Elisabetta Rosadoni, Alessia Colombo, Elena Lucenti, Daniele Marinotto, Chiara Botta, Fabio Bellina, Elena Cariati and Alessandra Forni
Molecules 2024, 29(9), 1967; https://doi.org/10.3390/molecules29091967 (registering DOI) - 25 Apr 2024
Abstract
Organic room temperature phosphorescent (ORTP) materials with stimuli-responsive, multicomponent emissive behaviour are extremely desirable for various applications. The derivative of cyclic triimidazole (TT) functionalized with an ethynyl group, TT-CCH, is isolated and investigated. The compound possesses crystallization-enhanced emission (CEE) comprising [...] Read more.
Organic room temperature phosphorescent (ORTP) materials with stimuli-responsive, multicomponent emissive behaviour are extremely desirable for various applications. The derivative of cyclic triimidazole (TT) functionalized with an ethynyl group, TT-CCH, is isolated and investigated. The compound possesses crystallization-enhanced emission (CEE) comprising dual fluorescence and dual phosphorescence of both molecular and supramolecular origin with aggregation-induced components highly sensitive to grinding. The mechanisms involved in the emissions have been disclosed thanks to combined structural, spectroscopic and computational investigations. In particular, strong CH⋯N hydrogen bonds are deemed responsible, for the first time in the TT family, together with frequently observed π⋯π stacking interactions, for the aggregated fluorescence and phosphorescence. Full article
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17 pages, 6214 KiB  
Article
TiO2—MoS2—PMMA Nanocomposites for an Efficient Water Remediation
by Vanessa Spanò, Maria Cantarella, Massimo Zimbone, Federico Giuffrida, Gianfranco Sfuncia, Giuseppe Nicotra, Alessandra Alberti, Silvia Scalese, Libera Vitiello, Sabrina Carola Carroccio and Giuliana Impellizzeri
Polymers 2024, 16(9), 1200; https://doi.org/10.3390/polym16091200 (registering DOI) - 25 Apr 2024
Abstract
An improvement of water supply and sanitation and better management of water resources, especially in terms of water reuse, is one of the priorities of the European Green Deal. In this context, it is crucial to find new strategies to recycle wastewater efficiently [...] Read more.
An improvement of water supply and sanitation and better management of water resources, especially in terms of water reuse, is one of the priorities of the European Green Deal. In this context, it is crucial to find new strategies to recycle wastewater efficiently in a low-cost and eco-friendly manner. The immobilization of inorganic nanomaterials on polymeric matrices has been drawing a lot of attention in recent years due to the extraordinary properties characterizing the as-obtained nanocomposites. The hybrid materials, indeed, combine the properties of the polymers, such as flexibility, low cost, mechanical stability, high durability, and ease of availability, with the properties of the inorganic counterpart. In particular, if the inorganic fillers are nanostructured photocatalysts, the materials will be able to utilize the energy delivered by light to catalyze chemical reactions for efficient wastewater treatment. Additionally, with the anchoring of the nanomaterials to the polymers, the dispersion of the nanomaterials in the environment is prevented, thus overcoming one of the main limits that impede the application of nanostructured photocatalysts on a large scale. In this work, we will present nanocomposites made of polymers, i.e., polymethyl methacrylate (PMMA), and photocatalytic semiconductors, i.e., TiO2 nanoparticles (Evonik). MoS2 nanoflakes were also added as co-catalysts to improve the photocatalytic performance of the TiO2. The hybrid materials were prepared using the sonication and solution casting method. The nanocomposites were deeply characterized, and their remarkable photocatalytic abilities were evaluated by the degradation of two common water pollutants: methyl orange and diclofenac. The relevance of the obtained results will be discussed, opening the route for the application of these materials in photocatalysis and especially for novel wastewater remediation. Full article
(This article belongs to the Section Polymer Composites and Nanocomposites)
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17 pages, 305 KiB  
Article
Metaphorical Language and Function of the “Bridal Pick-Up” Ritual in Anatolian Traditional Weddings with Its Origin and Reflections
by Atila Kartal, Kemal Şimşek, Emine Atmaca and Haktan Kaplan
Religions 2024, 15(5), 530; https://doi.org/10.3390/rel15050530 (registering DOI) - 25 Apr 2024
Abstract
In the urban centers of Türkiye, where cultural changes are more widespread and effective, wedding processional is replaced by the solemnization of the marriage at indoor weddings, and the Kūdegū (old Turkic language; refers to bridegroom, son-in-law) awaiting the bride’s arrival at the [...] Read more.
In the urban centers of Türkiye, where cultural changes are more widespread and effective, wedding processional is replaced by the solemnization of the marriage at indoor weddings, and the Kūdegū (old Turkic language; refers to bridegroom, son-in-law) awaiting the bride’s arrival at the boy’s house is replaced by differences in the way of the bride and groom’s entry together; moreover, while wedding rituals such as the bridal bath and groom’s hammam are being forgotten, bachelor/bachelorette parties are on the rise. The beliefs and practices related to the bride being taken out of the girl’s house with a special ceremony have deep meanings, such as blessing the bride who has just joined the family, acclimatizing the bride who feels like an outsider and avoiding her from these feelings, and protecting the bride and groom from the körmös (spirits in Turkic mythology, devilish entities living in the underworld), bad spirits, and the evil eye. In this paper, the structure, function, practices, and beliefs of the rituals surrounding the bride and groom on the last day of Anatolian Turkish weddings are analyzed using a qualitative research method. In addition, this study identified the betrothal, performance, beliefs, and practices surrounding the ritual of “bridal pick up” among Anatolian Turks and evaluated the symbols and signs in the ritual procedures in the functional context of the origins and reflections of traditional Turkish beliefs. Full article
(This article belongs to the Special Issue The Role of Religion in Marriage and Family Life)
16 pages, 23324 KiB  
Article
Optimization Method for Space-Based Target Detection System Based on Background-Oriented Schlieren
by Kang Li, Feng Zhou, Yun Su, Weihe Ren, Yue Zhang, Jiaquan Deng and Ruiyan Shan
Sensors 2024, 24(9), 2731; https://doi.org/10.3390/s24092731 (registering DOI) - 25 Apr 2024
Abstract
Currently, the visual detection of a target’s shock flow field through background schlieren technology is a novel detection system. However, there are very few studies on the long-distance background schlieren imaging mechanism and its application in system design in the field of target [...] Read more.
Currently, the visual detection of a target’s shock flow field through background schlieren technology is a novel detection system. However, there are very few studies on the long-distance background schlieren imaging mechanism and its application in system design in the field of target detection. This paper proposes a design optimization method for space-based BOS detection system metrics. By establishing sensitivity evaluation models and image signal-to-noise ratio evaluation models for BOS detection systems, the influence of the different flight parameters and key parameters of BOS systems (detection spectral bands and spatial resolution) on target detection efficiency is explored. Furthermore, an optimization method based on the image signal-to-noise ratio of the BOS system and the overall metrics for specific scenarios are provided. The simulation results demonstrate that under satellite background images and speckle background images, the system metrics can detect and identify the schlieren of high-speed targets, with better applicability to disordered and complex real background images. This research contributes to advancing the development of high-speed target detection technology based on BOS. Full article
(This article belongs to the Section Optical Sensors)
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13 pages, 508 KiB  
Article
Niches Seeking Legitimacy: Notes about Social Innovation and Forms of Social Enterprise in the Italian Renewable Energy Communities
by Lorenzo De Vidovich
Sustainability 2024, 16(9), 3599; https://doi.org/10.3390/su16093599 (registering DOI) - 25 Apr 2024
Abstract
Renewable energy communities (RECs) are increasingly seen as key innovations for the development of decentralized energy systems that leverage on renewable energy co-production, sharing, and consumption. However, they still represent a niche in search of development and consolidation, and the social innovations they [...] Read more.
Renewable energy communities (RECs) are increasingly seen as key innovations for the development of decentralized energy systems that leverage on renewable energy co-production, sharing, and consumption. However, they still represent a niche in search of development and consolidation, and the social innovations they might bring to the energy systems need to be further scrutinized. Innovations related to the capacity to support forms of social entrepreneurship in the energy system are central to this analysis, even if they have been little studied in Italy in relation to the emerging field of renewable energy communities. Through a theoretical discussion aimed at fulfilling descriptive objectives, this paper examines, on the one hand, the social innovations related to community energy projects and, with a focus on Italy, the legal forms required to create an REC in the light of the constantly changing regulatory framework, where new actors, such as the Third Sector, can play a leading role as intermediary actors to develop the social implementation of REC initiatives. The paper navigates through the literature on community energy in the light of the social innovation they can bring to the energy system, discusses the niche condition of RECs, and addresses the Italian case with particular reference to the role of the Third Sector in disseminating REC innovations. Full article
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15 pages, 2295 KiB  
Article
Sociodemographic Trends in Planetary Health Diets among Nutrition Students in Türkiye: Bridging Classroom to Kitchen
by Semra Navruz-Varlı, Hande Mortaş and Menşure Nur Çelik
Nutrients 2024, 16(9), 1277; https://doi.org/10.3390/nu16091277 (registering DOI) - 25 Apr 2024
Abstract
This study aimed to investigate the effects of sociodemographic parameters on healthy and sustainable nutrition in nutrition students. This cross-sectional study was conducted with 601 students. Researchers administered questionnaire forms to gather sociodemographic information such as age, gender, geographical region, residence area, accommodation, [...] Read more.
This study aimed to investigate the effects of sociodemographic parameters on healthy and sustainable nutrition in nutrition students. This cross-sectional study was conducted with 601 students. Researchers administered questionnaire forms to gather sociodemographic information such as age, gender, geographical region, residence area, accommodation, BMI, and income level. Participants’ 24 h dietary records were used to evaluate Healthy Eating Index-2020 (HEI-2020) and Planetary Health Diet Index (PHDI). The mean PHDI scores of the Marmara (53.4 ± 14.9), Aegean (58.2 ± 18.3), Mediterranean (55.3 ± 15.5), and Black Sea (55.5 ± 15.7) regions, which are the coastal regions of Türkiye, were significantly higher than for the Central Anatolia region (46.7 ± 15.1). The PHDI and HEI-2020 score means of students living in metropolitan cities and rural areas were significantly higher than those living in urban areas (p < 0.05). Being in the 20–25 years age group increased the probability of being in a lower PHDI group (AOR 1.82; 95% CI 1.07:3.12; p = 0.028). While a similar result was found in the 20–25 years age group for HEI-2020, income level and gender did not have a statistically significant effect on these scores. Since students’ ages, geographical regions, and residence areas affect PHDI and HEI-2020, it is considered important to take these sociodemographic variables into consideration in guidelines and studies. Full article
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19 pages, 3608 KiB  
Article
Differential Solvent DEEP-STD NMR and MD Simulations Enable the Determinants of the Molecular Recognition of Heparin Oligosaccharides by Antithrombin to Be Disentangled
by Michela Parafioriti, Stefano Elli, Juan C. Muñoz-García, Jonathan Ramírez-Cárdenas, Edwin A. Yates, Jesús Angulo and Marco Guerrini
Int. J. Mol. Sci. 2024, 25(9), 4669; https://doi.org/10.3390/ijms25094669 (registering DOI) - 25 Apr 2024
Abstract
The interaction of heparin with antithrombin (AT) involves a specific sequence corresponding to the pentasaccharide GlcNAc/NS6S-GlcA-GlcNS3S6S-IdoA2S-GlcNS6S (AGA*IA). Recent studies have revealed that two AGA*IA-containing hexasaccharides, which differ in the sulfation degree of the iduronic acid unit, exhibit similar binding to AT, albeit with [...] Read more.
The interaction of heparin with antithrombin (AT) involves a specific sequence corresponding to the pentasaccharide GlcNAc/NS6S-GlcA-GlcNS3S6S-IdoA2S-GlcNS6S (AGA*IA). Recent studies have revealed that two AGA*IA-containing hexasaccharides, which differ in the sulfation degree of the iduronic acid unit, exhibit similar binding to AT, albeit with different affinities. However, the lack of experimental data concerning the molecular contacts between these ligands and the amino acids within the protein-binding site prevents a detailed description of the complexes. Differential epitope mapping (DEEP)-STD NMR, in combination with MD simulations, enables the experimental observation and comparison of two heparin pentasaccharides interacting with AT, revealing slightly different bound orientations and distinct affinities of both glycans for AT. We demonstrate the effectiveness of the differential solvent DEEP-STD NMR approach in determining the presence of polar residues in the recognition sites of glycosaminoglycan-binding proteins. Full article
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13 pages, 1262 KiB  
Article
Randomized Controlled Trial of Cardiac Rehabilitation Using the Balance Exercise Assist Robot in Older Adults with Cardiovascular Disease
by Akihiro Hirashiki, Atsuya Shimizu, Takahiro Kamihara, Manabu Kokubo, Kakeru Hashimoto, Ikue Ueda, Kenji Sato, Koki Kawamura, Naoki Itoh, Toyoaki Murohara, Hitoshi Kagaya and Izumi Kondo
J. Cardiovasc. Dev. Dis. 2024, 11(5), 133; https://doi.org/10.3390/jcdd11050133 (registering DOI) - 25 Apr 2024
Abstract
Background: Recent studies have investigated the effects of exercise on the functional capacity of older adults; training with a balance exercise assist robot (BEAR) effectively improves posture. This study compared the clinical safety and efficacy of training using BEAR video games to conventional [...] Read more.
Background: Recent studies have investigated the effects of exercise on the functional capacity of older adults; training with a balance exercise assist robot (BEAR) effectively improves posture. This study compared the clinical safety and efficacy of training using BEAR video games to conventional resistance training in older adults with cardiovascular disease (CVD). Methods: Ninety patients (mean age: 78 years) hospitalized due to worsening CVD were randomized to cardiac rehabilitation (CR) Group R (conventional resistance training) or Group B (training using BEAR). After appropriate therapy, patients underwent laboratory testing and functional evaluation using the timed up-and-go test (TUG), short physical performance battery (SPPB), and functional independence measure (FIM) just before discharge and 4 months after CR. The rates of CVD readmission, cardiac death, and fall-related fractures were monitored. Results: BEAR had no adverse effects during exercise. At 4 months, TUG and SPPB improved significantly in both groups, with no significant difference between them. FIM motor and the Geriatric Nutritional Risk Index were significantly improved in Group B versus Group R. There was no significant difference in cardiac events and fall-related fractures between the two groups. Conclusion: CR with BEAR is safe and comparable to conventional resistance training for improving balance in older adults with CVD. Full article
(This article belongs to the Special Issue Exercise and Cardiovascular Disease in Older Adults)
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20 pages, 3455 KiB  
Article
An Efficient Methodology to Identify Relevant Multiple Contingencies and Their Probability for Long-Term Resilience Studies
by Emanuele Ciapessoni, Diego Cirio and Andrea Pitto
Energies 2024, 17(9), 2028; https://doi.org/10.3390/en17092028 (registering DOI) - 25 Apr 2024
Abstract
The selection of multiple contingency scenarios is a key task to perform resilience-oriented long-term planning analyses. However, the identification of relevant multiple contingencies may easily lead to combinatorial explosion issues, even for relatively small systems. This paper proposes an effective methodology for the [...] Read more.
The selection of multiple contingency scenarios is a key task to perform resilience-oriented long-term planning analyses. However, the identification of relevant multiple contingencies may easily lead to combinatorial explosion issues, even for relatively small systems. This paper proposes an effective methodology for the identification of relevant multiple contingencies and their probabilities, suitable for the long-term resilience analysis of large power systems. The methodology is composed of two main pillars: (1) the clustering of lines that are more likely to fail together, to reduce the computational complexity of the analysis exploiting historical weather data and (2) the probability-based identification of multiple contingencies within each cluster, where the contingency probability is computed applying the copula theory. Tests performed on a portion of the Italian EHV transmission system confirm the validity of the clustering results compared against historical failure events. Moreover, the copula-based algorithm for contingency probability estimation passes the tests carried out on relatively large clusters with very low error tolerance. The method successfully pinpoints critical multiple contingency scenarios and their likelihoods, making it valuable for assessing power system resilience over long-term horizons in support of resilience-oriented planning activities. Full article
(This article belongs to the Section F1: Electrical Power System)
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10 pages, 2363 KiB  
Article
Evolution of the Electronic Properties of Tellurium Crystals with Plasma Irradiation Treatment
by Congzhi Bi, Tianyu Wu, Jingjing Shao, Pengtao Jing, Hai Xu, Jilian Xu, Wenxi Guo, Yufei Liu and Da Zhan
Nanomaterials 2024, 14(9), 750; https://doi.org/10.3390/nano14090750 (registering DOI) - 25 Apr 2024
Abstract
Tellurium exhibits exceptional intrinsic electronic properties. However, investigations into the modulation of tellurium’s electronic properties through physical modification are notably scarce. Here, we present a comprehensive study focused on the evolution of the electronic properties of tellurium crystal flakes under plasma irradiation treatment [...] Read more.
Tellurium exhibits exceptional intrinsic electronic properties. However, investigations into the modulation of tellurium’s electronic properties through physical modification are notably scarce. Here, we present a comprehensive study focused on the evolution of the electronic properties of tellurium crystal flakes under plasma irradiation treatment by employing conductive atomic force microscopy and Raman spectroscopy. The plasma-treated tellurium experienced a process of defect generation through lattice breaking. Prior to the degradation of electronic transport performance due to plasma irradiation treatment, we made a remarkable observation: in the low-energy region of hydrogen plasma-treated tellurium, a notable enhancement in conductivity was unexpectedly detected. The mechanism underlying this enhancement in electronic transport performance was thoroughly elucidated by comparing it with the electronic structure induced by argon plasma irradiation. This study not only fundamentally uncovers the effects of plasma irradiation on tellurium crystal flakes but also unearths an unprecedented trend of enhanced electronic transport performance at low irradiation energies when utilizing hydrogen plasma. This abnormal trend bears significant implications for guiding the prospective application of tellurium-based 2D materials in the realm of electronic devices. Full article
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15 pages, 5223 KiB  
Article
Optimising Ion Conductivity in NdBaInO4-Based Phases
by Manyu Chen, Cheng Li, Kai Zhu, Jieyu Wang, Sida Liu, Weina Kong, Zifa Ban and Chao Shen
Energies 2024, 17(9), 2029; https://doi.org/10.3390/en17092029 (registering DOI) - 25 Apr 2024
Abstract
Based on the previous work conducted by Fujii et al., NdBaInO4 compounds present modest oxide-ion conductivities. Therefore, it has been an attractive system of significant interest. In this study, we attempted to partially substitute Ca for Nd and the total electrical conductivity [...] Read more.
Based on the previous work conducted by Fujii et al., NdBaInO4 compounds present modest oxide-ion conductivities. Therefore, it has been an attractive system of significant interest. In this study, we attempted to partially substitute Ca for Nd and the total electrical conductivity was successfully improved due to the generation of oxygen vacancies. The synthesis, crystal structure, density, surface topography, and electrical properties of NdBaInO4 and Ca-doped NdBaInO4 have been studied, respectively. NdBaInO4 and 10% and 20% molar fractions of Ca-doped NdBaInO4 were synthesized through solid-state reactions. The crystal structure of them was obtained from Le Bail refinement of the XRD pattern, giving the result of the monoclinic structure, which belongs to P21/c space group. The highest total electrical conductivity of 4.91 × 10−3 S cm−1 was obtained in the Nd0.9Ca0.1BaInO3.95 sample at a temperature of 760 °C in the dry atmosphere and the activation energy was reduced from 0.68 eV to 0.58 eV when the temperature was above 464 °C (737 K) after doping the NdBaInO4 with a 0.1 molar fraction of Ca2+. Moreover, the total conductivity of Nd0.9Ca0.1BaInO3.95 in the wet atmosphere at moderate temperature was relatively higher than that in the dry atmosphere, which suggests that potential proton conduction may exist in wet atmospheres. In addition, the oxygen diffusion coefficients of Nd0.9Ca0.1BaInO3.95 (D* = 1.82 × 10−8 cm2/s, 850 °C) was about two times higher than that of Nd0.8Ca0.2BaInO3.90 (D* = 7.95 × 10−9 cm2/s, 850 °C) and was increased significantly by two orders of magnitude when compared with the oxygen diffusion coefficient of the undoped NdBaInO4 (D* = 8.25 × 10−11 cm2/s, 850 °C). Full article
(This article belongs to the Section D1: Advanced Energy Materials)
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36 pages, 5284 KiB  
Review
Exploring the Biomedical Potential of Terpenoid Alkaloids: Sources, Structures, and Activities
by Xuyan Wang, Jianzeng Xin, Lili Sun, Yupei Sun, Yaxi Xu, Feng Zhao, Changshan Niu and Sheng Liu
Molecules 2024, 29(9), 1968; https://doi.org/10.3390/molecules29091968 (registering DOI) - 25 Apr 2024
Abstract
Terpenoid alkaloids are recognized as a class of compounds with limited numbers but potent biological activities, primarily derived from plants, with a minor proportion originating from animals and microorganisms. These alkaloids are synthesized from the same prenyl unit that forms the terpene skeleton, [...] Read more.
Terpenoid alkaloids are recognized as a class of compounds with limited numbers but potent biological activities, primarily derived from plants, with a minor proportion originating from animals and microorganisms. These alkaloids are synthesized from the same prenyl unit that forms the terpene skeleton, with the nitrogen atom introduced through β-aminoethanol, ethylamine, or methylamine, leading to a range of complex and diverse structures. Based on their skeleton type, they can be categorized into monoterpenes, sesquiterpenes, diterpenes, and triterpene alkaloids. To date, 289 natural terpenoid alkaloids, excluding triterpene alkaloids, have been identified in studies published between 2019 and 2024. These compounds demonstrate a spectrum of biological activities, including anti-inflammatory, antitumor, antibacterial, analgesic, and cardioprotective effects, making them promising candidates for further development. This review provides an overview of the sources, chemical structures, and biological activities of natural terpenoid alkaloids, serving as a reference for future research and applications in this area. Full article
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22 pages, 6185 KiB  
Article
Stability-Indicating UPLC-PDA-QDa Methodology for Carvedilol and Felodipine in Fixed-Dose Combinations Using AQbD Principles
by Jesús Alberto Afonso Urich, Viktoria Marko, Katharina Boehm, Raymar Andreina Lara Garcia, Anna Fedorko, Sharareh Salar-Behzadi and Dalibor Jeremic
Sci. Pharm. 2024, 92(2), 22; https://doi.org/10.3390/scipharm92020022 (registering DOI) - 25 Apr 2024
Abstract
The development of analytical procedures, in line with the recent regulatory requirements ICH Q2 (R2) and ICH Q14, is progressing, and it must be able to manage the entire life cycle of the methodology. This is also applicable to and especially challenging for [...] Read more.
The development of analytical procedures, in line with the recent regulatory requirements ICH Q2 (R2) and ICH Q14, is progressing, and it must be able to manage the entire life cycle of the methodology. This is also applicable to and especially challenging for combinations of drug substances and dosage form. A reliable and efficient, stability-indicating, MS-compatible, reverse-phase ultra-performance liquid chromatographic (UPLC®) method was developed for the determination of carvedilol and felodipine in a combination oral dosage form. The development of the method, performed using analytical quality by design (AQbD) principles, was in line with the future regulatory requirements. Furthermore, the fixed-dose combination dosage forms are a clear solution to the polypharmacy phenomenon in the elderly population. The main factors evaluated were the mobile phase buffer, organic modifier, column, flow, and column temperature. The optimum conditions were achieved with a Waters Acquity HSS T3 (100 × 2.1 mm i.d., 1.8 µm) column at 38 °C, using ammonium acetate buffer (5 mM, pH 4.5) (Solution A) and MeOH (Solution B) as mobile phases in gradient elution (t = 0 min, 10% B; t = 1.5 min, 10% B; t = 12.0 min, 90% B; t = 13.0 min, 10% B; t = 15.5 min, 10% B) at a flow rate of 0.2 mL/min and UV Detection of 240 and 362 nm for carvedilol (CAV) and felodipine (FLP), respectively. The linearity was demonstrated over concentration ranges of 30–650 µg/mL (R2 = 0.9984) (CAV) and 32–260 µg/mL (R2 = 0.9996) (FLP). Forced degradation studies were performed by subjecting the samples to hydrolytic (acid and base), oxidative, and thermal stress conditions. Standard solution stability was also performed. The proposed validated method was successfully used for the quantitative analysis of bulk, stability, and fixed-dose combination dosage form samples of the desired drug product. Using the AQbD principles, it is possible to generate methodologies with improved knowledge, leading to high-quality data, lower operation costs, and minimum regulatory risk. Furthermore, this work paves the way for providing a platform of robust analytical methods for the simultaneous quantification of innovative on-demand new dose combinations. Full article
(This article belongs to the Special Issue Feature Papers in Scientia Pharmaceutica)
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10 pages, 1173 KiB  
Article
Are We Able to Prevent Neonatal Readmission? A Retrospective Analysis from a Pediatrics Department in Ploiești, Romania
by Ioana Roșca, Andreea Teodora Constantin, Daniela Eugenia Popescu, Ana Maria Cristina Jura, Anca Miu and Alina Turenschi
Medicina 2024, 60(5), 705; https://doi.org/10.3390/medicina60050705 (registering DOI) - 25 Apr 2024
Abstract
Background and Objectives: Early discharge after childbirth has led to a rise in neonatal readmission, thereby becoming a major concern in recent decades. Our research aimed to identify the risk factors and incidence of neonatal readmission and explore preventive measures. Materials and [...] Read more.
Background and Objectives: Early discharge after childbirth has led to a rise in neonatal readmission, thereby becoming a major concern in recent decades. Our research aimed to identify the risk factors and incidence of neonatal readmission and explore preventive measures. Materials and Methods: Our study at the Clinical Hospital of Pediatrics in Ploiești, Romania, included 108 neonates admitted during the neonatal period. Results: This accounted for 2.06% of all admissions (5226). The most prevalent cases were malnutrition (25%), fever (20.3%), and bronchiolitis (17.5%). Diarrhea and infectious gastroenteritis were also observed (14.8%), along with acute rhinoconjunctivitis (9.2%) and late-onset sepsis (3.7%). No deaths were recorded. The most significant characteristics identified were number of children (p < 0.001) and age at maternity discharge (p < 0.001). By following the prevention rules, malnutrition, feeding errors, and infections can be avoided. This includes practicing proper hand hygiene for both mothers and medical staff, as well as educating and demonstrating to mothers the benefits of breastfeeding. In addition, all newborns discharged from the maternity ward would benefit from follow-up at 7–10 days of life. Conclusions: Our results confirm the effectiveness of a multidisciplinary team and endorse the promotion of breastfeeding. Implementing quality control measures and regularly evaluating the surveillance program will help improve its effectiveness. Full article
(This article belongs to the Section Obstetrics and Gynecology)
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