The 2023 MDPI Annual Report has
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17 pages, 5341 KiB  
Article
Assessing the Potential of Teff Husk for Biochar Production through Slow Pyrolysis: Effect of Pyrolysis Temperature on Biochar Yield
by Marcin Landrat, Mamo Abawalo, Krzysztof Pikoń, Paulos Asefa Fufa and Semira Seyid
Energies 2024, 17(9), 1988; https://doi.org/10.3390/en17091988 (registering DOI) - 23 Apr 2024
Abstract
Environmental restoration and sustainable energy solutions require effective management and utilization of agricultural crop residues to reduce greenhouse gas emissions. Biowastes are a valuable resource that can be converted into biofuels and their byproducts, solving the energy crisis and reducing environmental impact. In [...] Read more.
Environmental restoration and sustainable energy solutions require effective management and utilization of agricultural crop residues to reduce greenhouse gas emissions. Biowastes are a valuable resource that can be converted into biofuels and their byproducts, solving the energy crisis and reducing environmental impact. In this study, teff husk, primarily generated in Ethiopia during the production of teff within the agro-industrial sector, is used as a feedstock for slow pyrolysis. Ethiopia generates an estimated annual production of over 1.75 million tons of teff husk, a significant portion of which is incinerated, resulting in significant pollution of the environment. This study focuses on assessing teff husk as a potential material for slow pyrolysis, a crucial stage in biochar production, to tap into its biochar-producing potential. To identify the composition of biomass, the teff husk underwent an initial analysis using thermogravimetry. The significant presence of fixed carbon indicates that teff husk is a viable candidate for pyrolytic conversion into biochar particles. The process of slow pyrolysis took place at three temperatures—specifically, 400, 450, and 500 °C. The maximum biochar yield was achieved by optimizing slow pyrolysis parameters including reaction time, temperature, and heating rate. The optimized reaction time, temperature, and heating rate of 120 min, 400 °C, and 4.2 °C/min, respectively, resulted in the highest biochar yield of 43.4 wt.%. Furthermore, biochar’s physicochemical, SEM-EDX, FTIR, and TGA characterization were performed. As the temperature of biochar increases, its carbon content and thermal stability increases as well. Unlike fuel recovery, the results suggest that teff-husk can be used as a feedstock for biochar production. Full article
(This article belongs to the Section A4: Bio-Energy)
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37 pages, 3491 KiB  
Review
lncRNA Biomarkers of Glioblastoma Multiforme
by Markéta Pokorná, Marie Černá, Stergios Boussios, Saak V. Ovsepian and Valerie Bríd O’Leary
Biomedicines 2024, 12(5), 932; https://doi.org/10.3390/biomedicines12050932 (registering DOI) - 23 Apr 2024
Abstract
Long noncoding RNAs (lncRNAs) are RNA molecules of 200 nucleotides or more in length that are not translated into proteins. Their expression is tissue-specific, with the vast majority involved in the regulation of cellular processes and functions. Many human diseases, including cancer, have [...] Read more.
Long noncoding RNAs (lncRNAs) are RNA molecules of 200 nucleotides or more in length that are not translated into proteins. Their expression is tissue-specific, with the vast majority involved in the regulation of cellular processes and functions. Many human diseases, including cancer, have been shown to be associated with deregulated lncRNAs, rendering them potential therapeutic targets and biomarkers for differential diagnosis. The expression of lncRNAs in the nervous system varies in different cell types, implicated in mechanisms of neurons and glia, with effects on the development and functioning of the brain. Reports have also shown a link between changes in lncRNA molecules and the etiopathogenesis of brain neoplasia, including glioblastoma multiforme (GBM). GBM is an aggressive variant of brain cancer with an unfavourable prognosis and a median survival of 14–16 months. It is considered a brain-specific disease with the highly invasive malignant cells spreading throughout the neural tissue, impeding the complete resection, and leading to post-surgery recurrences, which are the prime cause of mortality. The early diagnosis of GBM could improve the treatment and extend survival, with the lncRNA profiling of biological fluids promising the detection of neoplastic changes at their initial stages and more effective therapeutic interventions. This review presents a systematic overview of GBM-associated deregulation of lncRNAs with a focus on lncRNA fingerprints in patients’ blood. Full article
(This article belongs to the Special Issue Epigenetic Regulation and Its Impact for Medicine)
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22 pages, 5575 KiB  
Article
Advancing into Millimeter Wavelengths for IoT: Multibeam Modified Planar Luneburg Lens Antenna with Porous Plastic Material
by Javad Pourahmadazar, Bal S. Virdee and Tayeb A. Denidni
Electronics 2024, 13(9), 1605; https://doi.org/10.3390/electronics13091605 (registering DOI) - 23 Apr 2024
Abstract
This paper introduces an innovative antenna design utilizing a cylindrical dielectric Luneburg lens tailored for 60 GHz Internet of Things (IoT) applications. To optimize V-band communications, the permittivity of the dielectric medium is strategically adjusted by precisely manipulating the physical porosity. In IoT [...] Read more.
This paper introduces an innovative antenna design utilizing a cylindrical dielectric Luneburg lens tailored for 60 GHz Internet of Things (IoT) applications. To optimize V-band communications, the permittivity of the dielectric medium is strategically adjusted by precisely manipulating the physical porosity. In IoT scenarios, employing a microstrip dipole antenna with an emission pattern resembling cos10 enhances beam illumination within the waveguide, thereby improving communication and sensing capabilities. The refractive index gradient of the Luneburg lens is modified by manipulating the material’s porosity using air holes, prioritizing signal accuracy and reliability. Fabricated with polyimide using 3D printing, the proposed antenna features a slim profile ideal for IoT applications with space constraints, such as smart homes and unmanned aerial vehicles. Its innovative design is underscored by selective laser sintering (SLS), offering scalable and cost-effective production. Measured results demonstrate the antenna’s exceptional performance, surpassing IoT deployment standards. This pioneering approach to designing multibeam Luneburg lens antennas, leveraging 3D printing’s porosity control for millimeter-wave applications, represents a significant advancement in antenna technology with scanning ability between −67 and 67 degrees. It paves the way for enhanced IoT infrastructure characterized by advanced sensing capabilities and improved connectivity. Full article
(This article belongs to the Special Issue Antennas for IoT Devices)
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21 pages, 4566 KiB  
Article
A Novel Bio-Purification Process Employing an Engineered E. coli Strain for Downstream Processing of Lactic Acid Solutions from the Fermentation of Agro-Industrial by-Products
by Alexandra Nastouli, Alexandra Moschona, Panagiotis A. Bizirtsakis, Joseph Sweeney, Irini Angelidaki, Michael Harasek, Anastasios J. Karabelas and Sotiris I. Patsios
Bioengineering 2024, 11(5), 412; https://doi.org/10.3390/bioengineering11050412 (registering DOI) - 23 Apr 2024
Abstract
This study aims to integrate a novel bio-purification process employing an engineered E. coli strain in the downstream processing of lactic acid (LA) fermentation broths from low-cost renewable biological feedstocks. Fermentation broth of candy waste and digestate mixture was used as a real [...] Read more.
This study aims to integrate a novel bio-purification process employing an engineered E. coli strain in the downstream processing of lactic acid (LA) fermentation broths from low-cost renewable biological feedstocks. Fermentation broth of candy waste and digestate mixture was used as a real biological feedstock. An engineered E. coli strain that selectively catabolize impurities without catabolizing LA was initially adapted on the biological feedstock, followed by shake flask experiments to prove the bio-purification concept. Scale-up and validation in a bench-scale bioreactor followed, before developing a semi-continuous membrane bioreactor (MBR) bio-purification process. The MBR bio-purification was assessed with biological feedstocks which simulated ultrafiltration or nanofiltration permeates. Incomplete removal of impurities and increased fouling was observed in the case of the ultrafiltration permeate. Contrarily, the nanofiltration permeate was successfully treated with MBR bio-purification, since low membrane fouling, 100% maltose and acetic acid removal, and no LA catabolism was achieved. MBR bio-purification as a post-treatment step in the downstream processing of LA was demonstrated as a promising technology for increasing the purity of LA solutions. Full article
(This article belongs to the Special Issue Bio-Applications of Engineered Escherichia coli)
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26 pages, 933 KiB  
Review
A Roadmap of CAR-T-Cell Therapy in Glioblastoma: Challenges and Future Perspectives
by Megan Montoya, Marco Gallus, Su Phyu, Jeffrey Haegelin, John de Groot and Hideho Okada
Cells 2024, 13(9), 726; https://doi.org/10.3390/cells13090726 (registering DOI) - 23 Apr 2024
Abstract
Glioblastoma (GBM) is the most common primary malignant brain tumor, with a median overall survival of less than 2 years and a nearly 100% mortality rate under standard therapy that consists of surgery followed by combined radiochemotherapy. Therefore, new therapeutic strategies are urgently [...] Read more.
Glioblastoma (GBM) is the most common primary malignant brain tumor, with a median overall survival of less than 2 years and a nearly 100% mortality rate under standard therapy that consists of surgery followed by combined radiochemotherapy. Therefore, new therapeutic strategies are urgently needed. The success of chimeric antigen receptor (CAR) T cells in hematological cancers has prompted preclinical and clinical investigations into CAR-T-cell treatment for GBM. However, recent trials have not demonstrated any major success. Here, we delineate existing challenges impeding the effectiveness of CAR-T-cell therapy for GBM, encompassing the cold (immunosuppressive) microenvironment, tumor heterogeneity, T-cell exhaustion, local and systemic immunosuppression, and the immune privilege inherent to the central nervous system (CNS) parenchyma. Additionally, we deliberate on the progress made in developing next-generation CAR-T cells and novel innovative approaches, such as low-intensity pulsed focused ultrasound, aimed at surmounting current roadblocks in GBM CAR-T-cell therapy. Full article
(This article belongs to the Special Issue Cell and Immune Therapeutics for Gliomas)
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5 pages, 143 KiB  
Editorial
Towards a Sustainable Digital Ecosystem: Exploring New Frontiers in Information Systems
by Osama Sohaib
Sustainability 2024, 16(9), 3511; https://doi.org/10.3390/su16093511 (registering DOI) - 23 Apr 2024
Abstract
The digital revolution has undeniably propelled us forward, but not without a hidden cost [...] Full article
(This article belongs to the Special Issue Sustainable Information Systems)
9 pages, 580 KiB  
Article
Interaction of Colorectal Neoplasm Risk Factors and Association with Metabolic Health Status Focusing on Normal Waist-to-Hip Ratio in Adults
by Ying-Chun Lin, Hung-Ju Ko, Lo-Yip Yu, Ming-Jen Chen, Horng-Yuan Wang, Shou-Chuan Shih, Chuan-Chuan Liu, Yang-Che Kuo and Kuang-Chun Hu
Cancers 2024, 16(9), 1617; https://doi.org/10.3390/cancers16091617 (registering DOI) - 23 Apr 2024
Abstract
Background: We aimed to evaluate the interaction between colorectal adenoma risks among asymptomatic individuals in terms of metabolic health status and obesity, and examine the normal waist-to-hip ratio (WHR) in adults with colorectal adenoma risk. Methods: A cross-sectional, retrospective study was conducted at [...] Read more.
Background: We aimed to evaluate the interaction between colorectal adenoma risks among asymptomatic individuals in terms of metabolic health status and obesity, and examine the normal waist-to-hip ratio (WHR) in adults with colorectal adenoma risk. Methods: A cross-sectional, retrospective study was conducted at MacKay Memorial Hospital involving 16,996 participants who underwent bidirectional gastrointestinal endoscopy between 2013 and 2023. The study recorded important clinicopathological characteristics, including age, body mass index and WHR, Framingham Risk Score (FRS), blood glucose level, and Helicobacter pylori (H. pylori) infection status. Results: Multivariate logistic regression analysis demonstrated that elevated hemoglobin A1C (HbA1c), increased FRS, positive H. pylori infection, and WHR ≥ 0.9 are independent risk factors for colorectal adenoma. In examining the interaction between FRS and WHR using multivariate logistic regression to evaluate adenoma risk, the OR for the interaction term was 0.95, indicating a decline in adenoma risk when considering the interaction between these two factors. Incorporating HbA1c into the analysis, evaluating the interaction between FRS and WHR still demonstrated a statistically significant impact on adenoma risk (OR 0.96, p < 0.001). Participants with WHR < 0.9, elevated FRS, positive H. pylori infection, and increased HbA1c levels were associated with a higher risk of colorectal adenoma formation. Remarkably, the increased risk of adenoma due to rising HbA1c levels was statistically significant only for those with a WHR < 0.9. Conclusions: An increase in FRS and HbA1c or a positive H. pylori infection still warrants vigilance for colorectal adenoma risk when WHR is 0.9. These factors interacted with each other and were found to have a minimal decline in adenoma risk when considering the interaction between WHR and FRS. Full article
(This article belongs to the Section Cancer Epidemiology and Prevention)
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17 pages, 6057 KiB  
Article
Camel Milk Resistome in Kuwait: Genotypic and Phenotypic Characterization
by Rita Rahmeh, Abrar Akbar, Batlah Almutairi, Mohamed Kishk, Naida Babic Jordamovic, Abdulaziz Al-Ateeqi, Anisha Shajan, Heba Al-Sherif, Alfonso Esposito, Sabah Al-Momin and Silvano Piazza
Antibiotics 2024, 13(5), 380; https://doi.org/10.3390/antibiotics13050380 (registering DOI) - 23 Apr 2024
Abstract
Antimicrobial resistance (AMR) is one of the major global health and economic threats. There is growing concern about the emergence of AMR in food and the possibility of transmission of microorganisms possessing antibiotic resistance genes (ARGs) to the human gut microbiome. Shotgun sequencing [...] Read more.
Antimicrobial resistance (AMR) is one of the major global health and economic threats. There is growing concern about the emergence of AMR in food and the possibility of transmission of microorganisms possessing antibiotic resistance genes (ARGs) to the human gut microbiome. Shotgun sequencing and in vitro antimicrobial susceptibility testing were used in this study to provide a detailed characterization of the antibiotic resistance profile of bacteria and their ARGs in dromedary camel milk. Eight pooled camel milk samples, representative of multiple camels distributed in the Kuwait desert, were collected from retail stores and analyzed. The genotypic analysis showed the presence of ARGs that mediate resistance to 18 classes of antibiotics in camel milk, with the highest resistance to fluoroquinolones (12.48%) and disinfecting agents and antiseptics (9%). Furthermore, the results pointed out the possible transmission of the ARGs to other bacteria through mobile genetic elements. The in vitro antimicrobial susceptibility testing indicated that 80% of the isolates were resistant to different classes of antibiotics, with the highest resistance observed against three antibiotic classes: penicillin, tetracyclines, and carbapenems. Multidrug-resistant pathogens including Klebsiella pneumoniae, Escherichia coli, and Enterobacter hormaechei were also revealed. These findings emphasize the human health risks related to the handling and consumption of raw camel milk and highlight the necessity of improving the hygienic practices of farms and retail stores to control the prevalence of ARGs and their transmission. Full article
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30 pages, 9870 KiB  
Review
Insulation for Rotating Low-Voltage Electrical Machines: Degradation, Lifetime Modeling, and Accelerated Aging Tests
by Xuanming Zhou, Paolo Giangrande, Yatai Ji, Weiduo Zhao, Salman Ijaz and Michael Galea
Energies 2024, 17(9), 1987; https://doi.org/10.3390/en17091987 (registering DOI) - 23 Apr 2024
Abstract
The low-voltage electric machine (EM) is a core technology for transportation electrification, and features like high power density and compact volume are essential prerequisites. However, these requirements are usually in conflict with the reliability property of EM, especially in the safety-critical industry such [...] Read more.
The low-voltage electric machine (EM) is a core technology for transportation electrification, and features like high power density and compact volume are essential prerequisites. However, these requirements are usually in conflict with the reliability property of EM, especially in the safety-critical industry such as aviation. Therefore, an appropriate balance between high-performance and reliability needs to be found. Often, the over-engineering method is applied to ensure safety, although it might have a detrimental effect on the EM volume. To address this issue, the EM reliability assessment is included at the EM design stage through the physics of failure (PoF) theory. In EMs, the windings play a key role in electromechanical energy conversion, but their insulation system is subject to frequent failure and represents a reliability bottleneck. Therefore, in-depth research on the root causes of insulation breakdown is beneficial for EM reliability improvement purposes. Indeed, increasing awareness and knowledge on the mechanism of the insulation degradation process and the related lifetime modeling enables the growth of appropriate tools for achieving reliability targets since the first EM design steps. In this work, the main aspects of the insulation system, in terms of materials and manufacturing, are first reviewed. Then, the principal stresses experienced by the winding insulation system are deeply discussed with the purpose of building a profound understanding of the PoF. Finally, an overview of the most common insulation lifetime prediction models is presented, and their use for accomplishing the reliability-oriented design (RoD) and the remaining useful life (RUL) estimation are examined. Full article
(This article belongs to the Special Issue Reliability and Condition Monitoring of Electric Motors and Drives)
10 pages, 799 KiB  
Article
What about the Use of Ice Cream as a Supplementary Diet in Chronic Kidney Disease? A Case–Control Study
by Daniela Metro, Francesco Corallo, Davide Cardile, Guido Gembillo, Luigi Manasseri, Domenico Santoro, Martina Buda, Rocco Salvatore Calabrò and Lilla Bonanno
Med. Sci. 2024, 12(2), 22; https://doi.org/10.3390/medsci12020022 (registering DOI) - 23 Apr 2024
Abstract
Maintaining a healthy lifestyle can extend life expectancy and improve a person’s health status. In addition to physical activity and bad habits related to smoking and alcohol, diet is also a determining factor. Following a healthy diet pattern over time and supporting a [...] Read more.
Maintaining a healthy lifestyle can extend life expectancy and improve a person’s health status. In addition to physical activity and bad habits related to smoking and alcohol, diet is also a determining factor. Following a healthy diet pattern over time and supporting a healthy body weight contributes to reducing the risk of developing more severe complications associated with very common diseases such as chronic kidney disease (CKD), diabetes, or cardiovascular diseases. The 2015–2020 Dietary Guidelines for Americans promote the adoption of fat-free or low-fat diets and discourage the consumption of foods with added sugar and solid fats, such as ice creams and other frozen desserts. On the other hand, ice cream, from a nutritional and healthy point of view, can be considered a possible food choice, due to its greater palatability and high nutritional content, but its consumption must be scheduled in a balanced diet. In this retrospective study, 36 patients with chronic renal failure were enrolled. Two different diets were proposed (A and B). In Diet B, lemon sorbet was added twice a week as an alternative food to replace fruit or snacks making the diet more varied and palatable. Nutritional status and biohumoral, immunological, and blood parameters were evaluated after 6 months. A statistical analysis shows a significant inter-group difference in creatinine and azotemia between T0 and T1. Intra-group significant differences were found in lymphocytes (p = 0.005) and azotemia (p < 0.001) in Diet A, and in azotemia (p < 0.001) and transferrin (p < 0.001) in Diet B. The results indicated that ice cream represented a good alternative food in both groups of patients regarding nutritional values and patient satisfaction. Furthermore, the treatment with ice cream allowed for better control of azotemia, maintaining stable levels even in patients with advanced CKD. This study concludes that ice cream could exert beneficial effects in addition to CKD patients’ dietary regimens. Full article
(This article belongs to the Section Endocrinology and Metabolic Diseases)
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15 pages, 7043 KiB  
Article
Curcumin Inhibits α-Synuclein Aggregation by Acting on Liquid–Liquid Phase Transition
by Jian-Feng Li, Zi-Qun Jiang, Sen Cao, Meng-Xin Zhang, Li-Hui Wang, Jun Liu, Yan-Hua Lu, Hong-Yan Wang, Xiao-Jing Hong, Zhi-Guo Wang and Jun-Ping Liu
Foods 2024, 13(9), 1287; https://doi.org/10.3390/foods13091287 (registering DOI) - 23 Apr 2024
Abstract
Parkinson’s disease (PD), the second most common neurodegenerative disorder, is linked to α-synuclein (α-Syn) aggregation. Despite no specific drug being available for its treatment, curcumin, from the spice turmeric, shows promise. However, its application in PD is limited by a lack of understanding [...] Read more.
Parkinson’s disease (PD), the second most common neurodegenerative disorder, is linked to α-synuclein (α-Syn) aggregation. Despite no specific drug being available for its treatment, curcumin, from the spice turmeric, shows promise. However, its application in PD is limited by a lack of understanding of its anti-amyloidogenic mechanisms. In this study, we first reconstructed the liquid–liquid phase separation (LLPS) of α-Syn in vitro under different conditions, which may be an initial step in entraining the pathogenic aggregation. Subsequently, we evaluated the effects of curcumin on the formation of droplets, oligomers, and aggregated fibers during the LLPS of α-synuclein, as well as its impact on the toxicity of aggregated α-synuclein to cultured cells. Importantly, we found that curcumin can inhibit amyloid formation by inhibiting the occurrence of LLPS and the subsequent formation of oligomers of α-Syn in the early stages of aggregation. Finally, the molecular dynamic simulations of interactions between α-Syn decamer fibrils and curcumin showed that van der Waal’s interactions make the largest contribution to the anti-aggregation effect of curcumin. These results may help to clarify the mechanism by which curcumin inhibits the formation of α-Syn aggregates during the development of PD. Full article
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11 pages, 480 KiB  
Study Protocol
Be Cool: A Holistic and Innovative Approach to Rehabilitation in Multiple Sclerosis: Study Protocol for a Randomized Controlled Trial
by Antonia Kaltsatou, Sofia Theodorou and Anastasios Orologas
Healthcare 2024, 12(9), 870; https://doi.org/10.3390/healthcare12090870 (registering DOI) - 23 Apr 2024
Abstract
(1) Background: Individuals with multiple sclerosis (MS) have to deal with numerous symptoms that adversely impact their quality of life. While pharmaceutical treatments offer some relief, they often fall short of addressing the full spectrum of MS symptoms. To bridge this gap, we [...] Read more.
(1) Background: Individuals with multiple sclerosis (MS) have to deal with numerous symptoms that adversely impact their quality of life. While pharmaceutical treatments offer some relief, they often fall short of addressing the full spectrum of MS symptoms. To bridge this gap, we introduce the Be Cool rehabilitation program, a comprehensive protocol designed to enhance the well-being and life quality of MS individuals. (2) Methods: The Be Cool program is a multifaceted approach that combines exercise training, nutritional guidance, psychological support, and cooling strategies. Adapted to meet the unique needs of MS individuals, this program aims to mitigate symptoms, promote physical and mental health, and improve overall quality of life. The integration of these strategies addresses the complex challenges faced by MS individuals, offering a holistic solution beyond conventional medication. (3) Conclusions: The Be Cool rehabilitation protocol is designed to offer individuals with MS a comprehensive approach to symptom management, fostering improvements in their quality of life. By addressing the multifaceted nature of MS through an integrated strategy, the program holds promise for more effective management of the condition. Full article
(This article belongs to the Special Issue Exercise and Its Role in Health and Disease)
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13 pages, 2518 KiB  
Article
A Simulator Study on the Driving Impacts of Four Speed-Calming Measures at Unsignalized Intersections
by Yaqin Qin, Yang Wu and Miao Guo
Appl. Sci. 2024, 14(9), 3542; https://doi.org/10.3390/app14093542 (registering DOI) - 23 Apr 2024
Abstract
Intersections, especially those without traffic signals, are prone to frequent traffic accidents and disorder. The regulation of vehicle speed is an effective measure that can be taken in order to mitigate accidents and alleviate disorder at unsignalized intersections. This study aims to assess [...] Read more.
Intersections, especially those without traffic signals, are prone to frequent traffic accidents and disorder. The regulation of vehicle speed is an effective measure that can be taken in order to mitigate accidents and alleviate disorder at unsignalized intersections. This study aims to assess the effectiveness of four different temporary low-cost speed-calming measures: traffic crash barrels, lane markings, intersection markings, and a combination of the three. In this study, we used a driving simulator to design four speed-calming static measures that are typical of intersections; we then statistically analyzed the speed and acceleration data (recorded by the driving simulator) and the driver’s visual data (recorded by an eye tracker). The simulation results demonstrated that different speed-calming measures have varied effects on the attention and visual fixations of drivers; however, they are all effective in reducing the average driving speed at the intersection. The traffic-channelizing lane demonstrated superior performance compared to the other three measures in terms of its cumulative impact on deceleration, driving comfort, and safety. The experimental findings presented herein broaden the range of currently accessible temporary speed-limiting strategies and provide valuable insight into intersections that require low-cost speed management solutions. Full article
(This article belongs to the Section Transportation and Future Mobility)
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13 pages, 370 KiB  
Article
Emotional Intelligence in Hemodialysis Patients: The Impact of an Intradialytic Exercise Training Program
by Stefania S. Grigoriou, Christina Karatzaferi, Christoforos D. Giannaki and Giorgos K. Sakkas
Healthcare 2024, 12(9), 872; https://doi.org/10.3390/healthcare12090872 (registering DOI) - 23 Apr 2024
Abstract
The current study aimed to investigate whether there is a relationship between emotional intelligence (EI), functional capacity, fatigue, cognitive function, and quality of life (QoL) in HD patients and to assess the effect of a 9-month intradialytic exercise training program on EI levels. [...] Read more.
The current study aimed to investigate whether there is a relationship between emotional intelligence (EI), functional capacity, fatigue, cognitive function, and quality of life (QoL) in HD patients and to assess the effect of a 9-month intradialytic exercise training program on EI levels. Seventy-eight dialysis patients (50 M/28 F, 60.6 ± 17.2 years) participated in the cross-sectional study. Afterward, a subgroup of 18 patients (15 M/3 F, 56.7 ± 12.3 years) completed a 9-month supervised intradialytic exercise training program (three times weekly). EI was assessed by the Schutte Self Report Emotional Intelligence Test (SSEIT) and the Wong and Law Emotional Intelligence Scale (WLEIS). Functional capacity was assessed by a battery of tests. Sleep quality, depression levels, and daily sleepiness were assessed via validated questionnaires. All assessments were carried out before and after the intervention. A significant positive correlation was found between the WLEIS scores and the physical component summary of the QoL questionnaire. In contrast, the WLEIS scores were negatively associated with general and physical fatigue. The SSEIT scores were positively associated with cognitive function. After nine months of exercise training, only the group with low WLEIS scores improved their EI score significantly compared to the baseline values (98.7 ± 7.0 vs. 73.0 ± 4.0, p = 0.020), while no changes were observed in the medium or high EI groups. In conclusion, patients with higher levels of EI showed increased quality of life and lower levels of fatigue. Patients with low levels of EI are more likely to benefit from an exercise training program compared to their medium- and high-level counterparts. Full article
(This article belongs to the Special Issue Exercise Interventions and Testing for Effective Health Promotion)
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15 pages, 2385 KiB  
Article
Hydrolases Control Soil Carbon Sequestration in Alpine Grasslands in the Tibetan Plateau
by Yuanye Zhang, Xia Wang, Yuxin Sun, Jinhong Wu, Tao Deng, Menghan Yuan, Wenhui Duan and Yunfei Zhao
Sustainability 2024, 16(9), 3508; https://doi.org/10.3390/su16093508 (registering DOI) - 23 Apr 2024
Abstract
Microbial-sourced carbon is an important component of soil organic carbon (SOC) and influences SOC’s size and turnover. Soil extracellular enzymes can participate in the degradation of plants in the soil to produce substances needed by microorganisms, which in turn affects microbial sources of [...] Read more.
Microbial-sourced carbon is an important component of soil organic carbon (SOC) and influences SOC’s size and turnover. Soil extracellular enzymes can participate in the degradation of plants in the soil to produce substances needed by microorganisms, which in turn affects microbial sources of carbon. Most of the current studies focus on the effects of soil extracellular enzymes on SOC pools, while there is a lack of clarity regarding the effects on microbial sources of carbon during SOC pool formation. In this paper, three typical grassland types (alpine meadow, alpine grassland, and desert grassland, respectively) on the Tibetan Plateau were selected as research objects to investigate the effects of grassland type and soil depth on microbial-sourced carbon (amino sugars) and soil extracellular enzymes (hydrolytic enzymes: β-glucosidase and cellulase; oxidative enzymes: peroxidase and polyphenol oxidase) in the soil profiles. Our study shows that the content of amino sugars in the three grassland types followed the order: alpine meadow > alpine grassland > desert grassland; the content of hydrolytic enzyme followed the order of alpine meadow > alpine grassland > desert grassland; the content of oxidative enzyme followed the order of desert grassland > alpine grassland > alpine meadow; amino sugars content showed a positive correlation with hydrolytic enzymes and a negative correlation with oxidative enzymes; and the hydrolytic enzyme was the main factor promoting the accumulation of amino sugars. The environmental conditions of alpine meadows and alpine grasslands are more favorable for the formation of microbial-derived carbon and have greater sequestration potential, while desert grasslands are not favorable for the formation of microbial-derived carbon. The results of this study provide a reference basis for exploring the model of organic carbon sequestration in the Tibetan Plateau. Full article
(This article belongs to the Special Issue Soil Carbon Sequestration and Greenhouse Gas Emission)
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19 pages, 2777 KiB  
Article
A Framework for Assessing Food Baskets Based on Water and Carbon Footprints
by Ali Mohammadi, Saman Javadi, Hossein Yousefi, Hamed Pouraram and Timothy O. Randhir
Water 2024, 16(9), 1196; https://doi.org/10.3390/w16091196 (registering DOI) - 23 Apr 2024
Abstract
The composition of food baskets can significantly influence the water consumption rate and society’s environmental impact. This study evaluates the sustainability of Iran’s food and nutrition security by evaluating five food baskets using water and carbon-footprint indices. These food baskets are the common [...] Read more.
The composition of food baskets can significantly influence the water consumption rate and society’s environmental impact. This study evaluates the sustainability of Iran’s food and nutrition security by evaluating five food baskets using water and carbon-footprint indices. These food baskets are the common Iranian food basket (CIFB), the vegetarian food basket (VFB), the Ministry of Health desired food basket (MHDFB), the Swiss Society for Nutrition food basket (SSNFB), and the Mediterranean food basket (MFB). This study also examines the role of Iran’s agricultural sector under the Paris Climate Change Agreement (COP21). The TOPSIS multi-criteria decision-making method was used to identify the most desirable food basket. The results of this study show that the VFB could be the most desirable alternative to the CIFB. Replacing the CIFB with the VFB causes a 10% and 21% lower water and carbon footprint, respectively. From a 30-year perspective (around 2050), choosing the VFB would reduce the blue water footprint by 19.7 BCM and the gray water footprint by 3.6 BCM compared to the CIFB. According to the provisions of COP21 regarding Iran’s voluntary program to reduce greenhouse gas emissions, the agricultural sector will be one of the sources of greenhouse gas emissions that will face an upward trend. Hence, to adhere to this voluntary commitment, these emissions should be reduced by changing the CIFB to the VFB or reducing emissions in other sectors, such as industry. Choosing the VFB can reduce 10.7 million tons of CO2 emissions, which can be a significant step for the agricultural sector in Iran in reducing greenhouse gas emissions. Overall, considering the characteristics of farm products (water and carbon footprints) in Iran, a country located in a semi-arid climate, the VFB is recommended. Full article
(This article belongs to the Section Water Use and Scarcity)
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15 pages, 742 KiB  
Systematic Review
Associations of Atrioventricular Blocks and Other Arrhythmias in Patients with Lyme Carditis: A Systematic Review and Meta-Analysis
by Nismat Javed, Eduard Sklyar and Jonathan N. Bella
J. Cardiovasc. Dev. Dis. 2024, 11(5), 131; https://doi.org/10.3390/jcdd11050131 (registering DOI) - 23 Apr 2024
Abstract
Lyme disease often leads to cardiac injury and electrophysiological abnormalities. This study aimed to explore links between atrioventricular blocks and additional arrhythmias in Lyme carditis patients. This systematic review and meta-analysis of existing literature was performed from 1990 to 2023, and aimed to [...] Read more.
Lyme disease often leads to cardiac injury and electrophysiological abnormalities. This study aimed to explore links between atrioventricular blocks and additional arrhythmias in Lyme carditis patients. This systematic review and meta-analysis of existing literature was performed from 1990 to 2023, and aimed to identify cases of Lyme carditis through serology or clinical diagnosis with concomitant arrhythmias. Pubmed and Web of Science were searched using appropriate MESH terms. Patients were divided into groups with atrioventricular blocks and other arrhythmias for cardiovascular (CV) outcome assessment. A total of 110 cases were analyzed. The majority (77.3%) were male, with mean age = 39.65 ± 14.80 years. Most patients presented within one week of symptom onset (30.9%). Men were more likely to have first-degree atrioventricular blocks (OR = 1.36 [95% CI 1.12–3.96], p = 0.01); these blocks tended to be reversible in nature (OR = 1.51 [95% CI 1.39–3.92], p = 0.01). Men exhibited a higher likelihood of experiencing variable arrhythmias (OR = 1.31 [95% CI 1.08–2.16], p < 0.001). Ventricular and supraventricular arrhythmias were more likely to exhibit instability (OR = 0.96 [95% CI 0.81–1.16] p = 0.01) and variability (OR = 1.99 [95% CI 0.47–8.31], p < 0.001). Men with Lyme carditis are likely to present with various atrioventricular blocks. These atrioventricular blocks are benign, and follow a predictable and stable clinical course. Further large-scale studies are warranted to confirm these associations. Full article
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14 pages, 833 KiB  
Article
Impact of a Rounding Checklist Implementation in the Trauma Intensive Care Unit on Clinical Outcomes
by Dongmin Seo, Inhae Heo, Jonghwan Moon, Junsik Kwon, Yo Huh, Byunghee Kang, Seoyoung Song, Sora Kim and Kyoungwon Jung
Healthcare 2024, 12(9), 871; https://doi.org/10.3390/healthcare12090871 (registering DOI) - 23 Apr 2024
Abstract
We aimed to evaluate the effectiveness of an intensive care unit (ICU) round checklist, FAST HUGS BID (Feeding, Analgesia, Sedation, Thromboembolic prophylaxis, Head-of-bed elevation, Ulcer prophylaxis, Glycemic control, Spontaneous breathing trial, Bowel regimen, Indwelling catheter removal, and De-escalation of antibiotics—abbreviated as FD hereafter), [...] Read more.
We aimed to evaluate the effectiveness of an intensive care unit (ICU) round checklist, FAST HUGS BID (Feeding, Analgesia, Sedation, Thromboembolic prophylaxis, Head-of-bed elevation, Ulcer prophylaxis, Glycemic control, Spontaneous breathing trial, Bowel regimen, Indwelling catheter removal, and De-escalation of antibiotics—abbreviated as FD hereafter), in improving clinical outcomes in patients with severe trauma. We included patients admitted to our trauma ICU from 2016 to 2020 and divided them into two groups: before (before-FD, 2016–2017) and after (after-FD, 2019–2020) implementation of the checklist. We compared patient characteristics and clinical outcomes, including ICU and hospital length of stay (LOS) and in-hospital mortality. Survival analysis was performed using Kaplan–Meier curves and multivariable logistic regression models; furthermore, multiple linear regression analysis was used to identify independent factors associated with ICU and hospital LOS. Compared with the before-FD group, the after-FD group had significantly lower in-hospital mortality and complication rates, shorter ICU and hospital LOS, and reduced duration of mechanical ventilation. Moreover, implementation of the checklist was a significant independent factor in reducing ICU and hospital LOS and in-hospital mortality. Implementation of the FD checklist is associated with decreased ICU and hospital LOS and in-hospital mortality. Full article
(This article belongs to the Special Issue Acute Care Surgery)
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14 pages, 1684 KiB  
Article
Mean-Field Stackelberg Game-Based Security Defense and Resource Optimization in Edge Computing
by Li Miao, Shuai Li, Xiangjuan Wu and Bingjie Liu
Appl. Sci. 2024, 14(9), 3538; https://doi.org/10.3390/app14093538 (registering DOI) - 23 Apr 2024
Abstract
Edge computing brings computation and storage resources to the edge of the mobile network to solve the problems of low latency and high real-time demand. However, edge computing is more vulnerable to malicious attacks due to its open and dynamic environments. In this [...] Read more.
Edge computing brings computation and storage resources to the edge of the mobile network to solve the problems of low latency and high real-time demand. However, edge computing is more vulnerable to malicious attacks due to its open and dynamic environments. In this article, we investigate security defense strategies in edge computing systems, focusing on scenarios with one attacker and multiple defenders to determine optimal defense strategies with minimal resource allocation. Firstly, we formulate the interactions between the defenders and the attackers as the mean-field Stackelberg game model, where the state and the objective functions of the defenders are coupled through the mean-field term, and are strongly influenced by the strategy of the attacker. Then, we analyze the local optimal strategies of the defenders given an arbitrary strategy of the attackers. We demonstrate the Nash equilibrium and the mean-field equilibrium for both the defenders and the attackers. Finally, simulation analysis will illustrate the dynamic evolution of the defense strategy of the defenders and the trajectory of the attackers based on the proposed Stackelberg game model. Full article
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15 pages, 792 KiB  
Article
School Leadership and Management in Sindh Pakistan: Examining Headteachers’ Evolving Roles, Contemporary Challenges, and Adaptive Strategies
by Dhani Bux Shah, David Gurr and Lawrie Drysdale
Educ. Sci. 2024, 14(5), 440; https://doi.org/10.3390/educsci14050440 (registering DOI) - 23 Apr 2024
Abstract
This research investigates headteachers’ leadership and management roles and challenges in leading government secondary schools in Sindh, Pakistan. Employing a qualitative hermeneutic phenomenology methodology, forty semi-structured interviews were conducted with twenty headteachers. The thematic analysis of the data explored that headteachers were performing [...] Read more.
This research investigates headteachers’ leadership and management roles and challenges in leading government secondary schools in Sindh, Pakistan. Employing a qualitative hermeneutic phenomenology methodology, forty semi-structured interviews were conducted with twenty headteachers. The thematic analysis of the data explored that headteachers were performing several academic and administrative-focused responsibilities, although their involvement was more administrative than academic and entailed more management than leadership. However, headteachers faced enormous challenges in leading and managing their schools. Some critical challenges were a lack of basics in terms of clean water, reliable electricity, and sufficient school furniture. Others included a lack of funds, a shortage of teachers, managing professionally weak teachers, teacher union issues and a lack of authority. Nevertheless, some headteachers were making admirable efforts to address these challenges. This research may open a window to understanding the roles and challenges of headteachers and inform policymakers of how-to better support headteachers in leading their schools successfully in the 21st century. Full article
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12 pages, 248 KiB  
Article
Football Disasters and Pilgrimage: Commemoration through Religious and Non-Religious Ritual and Materiality
by John Eade
Religions 2024, 15(5), 518; https://doi.org/10.3390/rel15050518 (registering DOI) - 23 Apr 2024
Abstract
Although the relationship between religion and football has gained considerable interest during the last twenty years, scant attention has been paid to the relationship between pilgrimage and football. This paper seeks to advance the study of this relationship through an exploration of collective [...] Read more.
Although the relationship between religion and football has gained considerable interest during the last twenty years, scant attention has been paid to the relationship between pilgrimage and football. This paper seeks to advance the study of this relationship through an exploration of collective memory about football disasters that throws fresh light on central themes within pilgrimage studies—pilgrimage as both a journey to a sacred place and the performance of diverse rituals at such places. The paper explores, in particular, the ways in which three different tragedies involving English football clubs have been commemorated through journeys to and ritual performance at places seen as sacred to those involved in commemoration—football stadiums and urban spaces, and cathedrals and pilgrimage shrines in England, Germany and Italy. Through this analysis, we seek to show how the commemoration of football disaster is linked to pilgrimage as a process where people seek healing and reconciliation through the public performance of rituals that link the local to the global. Full article
(This article belongs to the Special Issue Pilgrimage and Religious Mobilization in the World)
26 pages, 8162 KiB  
Article
Starch-Based Polysaccharide Systems with Bioactive Substances: Physicochemical and Wettability Characteristics
by Agnieszka Ewa Wiącek and Anna Furmaniuk
Int. J. Mol. Sci. 2024, 25(9), 4590; https://doi.org/10.3390/ijms25094590 (registering DOI) - 23 Apr 2024
Abstract
Polysaccharide-based systems have very good emulsifying and stabilizing properties, and starch plays a leading role. Their modifications should add new quality features to the product to such an extent that preserves the structure-forming properties of native starch. The aim of this manuscript was [...] Read more.
Polysaccharide-based systems have very good emulsifying and stabilizing properties, and starch plays a leading role. Their modifications should add new quality features to the product to such an extent that preserves the structure-forming properties of native starch. The aim of this manuscript was to examine the physicochemical characteristics of the combinations of starch with phospholipids or lysozymes and determine the effect of starch modification (surface hydrophobization or biological additives) and preparation temperature (before and after gelatinization). Changes in electrokinetic potential (zeta), effective diameter, and size distribution as a function of time were analyzed using the dynamic light scattering and microelectrophoresis techniques. The wettability of starch-coated glass plates before and after modification was checked by the advancing and receding contact angle measurements, as well as the angle hysteresis, using the settle drop method as a complement to profilometry and FTIR. It can be generalized that starch dispersions are more stable than analogous n-alkane/starch emulsions at room and physiological temperatures. On the other hand, the contact angle hysteresis values usually decrease with temperature increase, pointing to a more homogeneous surface, and the hydrophobization effect decreases vs. the thickness of the substrate. Surface hydrophobization of starch carried out using an n-alkane film does not change its bulk properties and leads to improvement of its mechanical and functional properties. The obtained specific starch-based hybrid systems, characterized in detail by switchable wettability, give the possibility to determine the energetic state of the starch surface and understand the strength and specificity of interactions with substances of different polarities in biological processes and their applicability for multidirectional use. Full article
(This article belongs to the Special Issue New Perspectives of Colloids for Biological Applications)
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10 pages, 877 KiB  
Article
Comparison of the Surgical Outcome between the Multiple Screw Fixation and Fixed Angle Devices for the Basicervical Femoral Neck Fractures
by Jin-Woo Kim, Jung-Wee Park, Hyo-Jung Kim, Tae-Young Kim, Jun-Il Yoo, Young-Kyun Lee and Byung-Woong Jang
Medicina 2024, 60(5), 680; https://doi.org/10.3390/medicina60050680 - 23 Apr 2024
Abstract
Introduction: Basicervical femoral neck fracture (FNF) is an uncommon type of femoral neck fracture and is associated with an increased risk of fixation failure due to its inherent instability. The purpose of this study was to compare the surgical parameters and reoperation [...] Read more.
Introduction: Basicervical femoral neck fracture (FNF) is an uncommon type of femoral neck fracture and is associated with an increased risk of fixation failure due to its inherent instability. The purpose of this study was to compare the surgical parameters and reoperation rate between the use of a multiple cannulated screw (MCS) and fixed angle device (FAD) in treating basicervical FNFs. Methods: We retrospectively reviewed the records of 885 patients who underwent internal fixation between May 2004 and August 2019 to determine basicervical FNF with at least 12 months of follow-up. Among the identified 77 patients with basicervical FNF, 17 patients who underwent multiple cannulated screw (MCS) fixation and 36 patients who underwent fixed angle device (FAD) fixation were included. We compared the rates of fracture-site collapse and reoperations according to the fixation device. Results: Among the 53 patients with basicervical FNF, 13 patients (24.5%) sustained surgical complications (8 collapses of fracture site and 5 reoperations). The reoperation rate in the MCS group was significantly higher than that in the FAD group (23.5% vs. 2.8%, p = 0.016), without any significant difference in the collapse of the fracture site (11.8% vs. 16.7%, p = 0.642). Conclusions: Although basicervical FNF was rare among hip fractures, fracture site collapse was prevalent and prone to fixation failure. Surgeons should keep this in mind, and consider FAD for basicervical FNF. Full article
(This article belongs to the Special Issue Clinical Care and Updates on Hip Fractures)
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