Enhancing soil stability through the incorporation of straw and biochar is well documented. Nevertheless, the combined impact of straw, biochar, and nitrogen supplementation on soil aggregates and organic carbon still needs to be explored, with limited attention given to various sieving methods in the existing literature. Therefore, the current experiment used four sieving methods—routine wet sieving (RoutW), fast-wetting sieving (FastW), slow-wetting sieving (SlowW), and wetting–stirring sieving (WetS)—to investigate the effects of adding straw (0 or 4.5 t ha⁻¹), biochar (from maize straw, 0 or 15 t ha⁻¹), and N (0 or 100 kg ha⁻¹) on soil aggregate stability and soil organic C in silt–loam soil of rainfed farmland in northwest China. The field experiment was started in 2014; soil samples were collected in 2021. The results revealed that straw returned, biochar, and N addition significantly increased soil mean weight diameter (MWD) and soil organic C (SOC). Compared to CN0 (zero-amendment) plots, straw returned with nitrogen addition (SN100) significantly increased the MWD of aggregates by 130.3% (RoutW), 121.66% (FastW), 73.94% (SlowW), and 91.78% (WetS) in the 0–30 cm soil layer. The addition of biochar and nitrogen (BN100) treatment showed the most significant effects on the relative slaking index (RSI), relative mechanical breakdown index (RMI), and SOC; compared with CN0 treatment, BN100 plots can reduce RSI and RMI by 42.90% and 54.66% and increase SOC by 53.27% for all soil layers. Therefore, adding organic materials with N can enhance the stability of soil aggregates and SOC of silt–loam soils in northwest China. Integrating biochar as an organic soil amendment in the agricultural practices of northwest China presents a multifaceted solution that addresses soil health, crop productivity, and environmental sustainability. The current study provides valuable insights that support adopting this innovative approach, paving the way for future sustainable agricultural practices that can benefit both the region and the global community. Full article

Gamification involves integrating game mechanics into non-game environments such as business intranets, online communities, websites, and learning management systems to boost participation. Its aim is to actively engage employees, customers, and other stakeholders, fostering collaboration, sharing, and interaction. Gamification is a relatively unfamiliar term in Slovenia. The objective of this study is to investigate the influence of gamification on Slovenian consumers, specifically how it affects the online shopping process and user engagement during purchases. To test the hypotheses, we used appropriate statistical tools: chi-square, Friedman, and Wilcoxon tests. The findings indicate that gamification’s strongest influence is not on the post-purchase evaluation phase but rather on the alternative evaluation phase. It is interesting that highly rated reviewers significantly influence product purchases in online stores, while consumers are unwilling to increase their spending on online purchases in exchange for gamification-related benefits. Full article

Metastases are the most frequent intracranial malignant tumors in adults. While Karnofsky Performance Status (KPS) and Clinical Frailty Scale (CFS) are known to have significant impact on overall survival (OS), temporal muscle thickness (TMT) has been postulated to be a promising new parameter to estimate prognosis. Patients who received a resection of one to three brain metastases in our institution were included. Temporal muscle thickness was measured in preoperative MRI scans according to a standardized protocol. In 199 patients, the mean TMT was 7.5 mm (95CI 7.3–7.7) and the mean OS during follow-up was 31.3 months (95CI 24.2–38.3). There was no significant correlation of TMT and preoperative or follow-up CFS and KPS. While CFS and KPS did significantly correlate with OS (p < 0.001 for each), no correlation was demonstrated for TMT. CFS showed a superior prognostic value compared to KPS. TMT failed to show a significant impact on OS or patient performance, whereas the clinical scales (KPS and CFS) demonstrate a good correlation with OS. Due to its superiority over KPS, we strongly recommend the use of CFS to estimate OS in patients with brain metastases. Full article

Rare earth elements (REE) are a class of increasingly used high-tech product components and new emerging environmental pollutants, which are accumulated, in particular, in marine biota. In this study, REE contents were estimated in shells of several molluscs common in the Black Sea. The summed REE contents in mollusc shells decreased in the following order of species: Magallana gigas = Anadara kagoshimensis > Flexopecten glaber ponticus ≥ Rapana venosa > Mytilus galloprovincialis, ranging from 0.46 to 1.9 mg·kg⁻¹. Canonical analysis of principal coordinates allowed for the correct identification of species based on the REE composition in no fewer than 67% of the samples. The mollusc shells were anomalously enriched in Sc, Y, La, Eu and Tb, most likely due to anthropogenic contamination. The Y/Ho ratios in all samples were represented by two fit values: 23.2 (chondritic) and 67.6 (superchondritic, mainly associated with A. kagoshimensis). A new universal relationship linking the contents of three light and heavy REE in Black Sea mollusc shells was proposed: Ce^0.3 Er^0.7⁄Yb = 2.00 ± 0.46 (mean ± standard deviation). Full article

Surface mining is one of the hazardous industries that have several risky operations, including transportation, treatment, and mineral extraction. To avoid the risk of disaster, it is important to evaluate safety procedures and determine expected hazards. The aim of this study is to develop a thorough safety evaluation model for the surface mining industry based on the analytic hierarchy process (AHP), one important multi-criteria decision-making approach. A total of 11 criteria and 36 sub-criteria that are both independent and homogeneous were involved in the decision problem. Further, a deep sensitivity analysis was conducted to assess the stability of the ranking preference. The findings indicate that four out of the eleven criteria are particularly significant. To test the model’s applicability and effectiveness, a case study was conducted involving three surface mining companies located in the north of Jordan. The results demonstrate that the model is reliable, applicable, and effective in addressing real-world problems. Full article

The thymus provides maturation and migration of T cells to peripheral organs of immunity, where they recognize diverse antigens and maintain immunological memory and self-tolerance. The thymus is known to be involved with age and in response to stress factors. Therefore, the search for approaches to the restoration of thymopoiesis is of great interest. The present investigation was aimed at evaluating how prolonged deuterium depletion affects morphogenetic processes and the physiological transition of the thymus to age-related involution. The study was performed on 60 male Wistar rats subjected to consumption of deuterium-depleted water with a 10 ppm deuterium content for 28 days. The control rats consumed distilled water with a normal deuterium content of 150 ppm. The examination found no significant differences in body weight gain or the amount of water consumed. The exposed rats exhibited similar to control dynamics of the thymus weight but significant changes in thymic cell maturation according to cytofluorimetric analysis of thymic subpopulations. Changes in T cell production were not monotonic and differentially engaged morphogenetic processes of cell proliferation, differentiation, and migration. The reactive response to deuterium depletion was a sharp increase in the number of progenitor CD4⁻CD8⁻ cells and their differentiation into T cells. The compensatory reaction was inhibition of thymopoiesis with more pronounced suppression of differentiation of T-cytotoxic lymphocytes, followed by intensification of emigration of mature T cells to the bloodstream. This period lasts from 3 to 14 days, then differentiation of thymic lymphocytes is restored, later cell proliferation is activated, and finally the thymopoiesis rate exceeds the control values. The increase in the number of thymic progenitor cells after 3–4 weeks suggests consideration of deuterium elimination as a novel approach to prevent thymus involution. Full article

The aim of this study is to analyze the effect of the addition of TiO₂ nanoparticles (NTs) on the physical and mechanical properties, as well as the microstructural changes, of cementitious composites containing partially substituted natural aggregates (NAs) with aggregates derived from the following four recycled materials: glass (RGA), brick (RGB), blast-furnace slag (GBA), and recycled textolite waste with WEEE (waste from electrical and electronic equipment) as the primary source (RTA), in line with sustainable construction practices. The research methodology included the following phases: selection and characterization of raw materials, formulation design, experimental preparation and testing of specimens using standardized methods specific to cementitious composite mortars (including determination of apparent density in the hardened state, mechanical strength in compression, flexure, and abrasion, and water absorption by capillarity), and structural analysis using specialized techniques (scanning electron microscopy (SEM) images and energy dispersive X-ray spectroscopy (EDS)). The analysis and interpretation of the results focused primarily on identifying the effects of NT addition on the composites. Results show a decrease in density resulting from replacing NAs with recycled aggregates, particularly in the case of RGB and RTA. Conversely, the introduction of TiO₂ nanoparticles resulted in a slight increase in density, ranging from 0.2% for RTA to 7.4% for samples containing NAs. Additionally, the introduction of TiO₂ contributes to improved compressive strength, especially in samples containing RTA, while flexural strength benefits from a 3–4% TiO₂ addition in all composites. The compressive strength ranged from 35.19 to 70.13 N/mm², while the flexural strength ranged from 8.4 to 10.47 N/mm². The abrasion loss varied between 2.4% and 5.71%, and the water absorption coefficient varied between 0.03 and 0.37 kg/m²m^0.5, the variations being influenced by both the nature of the aggregates and the amount of NTs added. Scanning electron microscopy (SEM) images and energy dispersive X-ray spectroscopy (EDS) analysis showed that TiO₂ nanoparticles are uniformly distributed in the cementitious composites, mainly forming CSH gel. TiO₂ nanoparticles act as nucleating agents during early hydration, as confirmed by EDS spectra after curing. Full article

Amid China’s pursuit of a green and low-carbon transition, corporate social responsibility (CSR) is facing new challenges. Our research delves into the influencing factors and mechanisms for CSR reputation under green and low-carbon transition and provides practical enlightenment for enterprises to achieve sustainable development. This paper constructs a comprehensive index system of CSR from five dimensions (innovation, coordination, sustainability, openness, and sharing), and CSR reputation of China’s A-share listed companies is comprehensively estimated by using an entropy method and data from 2013 to 2021. Then, from the perspective of external supervision and internal governance, we discuss the influence factors of CSR reputation, with an emphasis on the impact of public environmental concerns. Finally, the realization mechanism of CSR is further revealed. It is found that public environmental concern and the expansion of the enterprise scale boost the enhancement of CSR reputation. However, a higher proportion of female managers tends to hinder CSR reputation. Furthermore, public environmental concern plays a more prominent role in improving CSR reputation of non-state-owned and eastern enterprises. Additionally, public environmental concern significantly enhances CSR reputation through green technology innovation and executive environmental awareness. This research provides valuable insights for improving CSR reputation and optimizing regulatory compliance and governance practices. Full article

In this study, we show that automata theory is also a suitable tool for analyzing a more complex type of the k-forcing process. First, the definition of k-forcing automata is presented according to the definition of k-forcing for graphs. Moreover, we study and discuss the language of k-forcing automata for particular graphs. Also, for some graphs with different k-forcing sets, we study the languages of their k-forcing automata. In addition, for some given recognizable languages, we study the structure of graphs. After that, we show that k-forcing automata arising from isomorph graphs are also isomorph. Also, we present the style of words that can be recognized with k-forcing automata. Moreover, we introduce the structure of graphs the k-forcing automata arising from which recognize some particular languages. To clarify the notions and the results obtained in this study, some examples are submitted as well. Full article

This investigation is motivated by an interest in multiferroic BaFe₁₂O₁₉ (BFO), which combines advanced ferrimagnetic and ferroelectric properties at room temperature and exhibits interesting magnetoelectric phenomena. The ferroelectric charge storage properties of BFO are limited due to high coercivity, low dielectric constant, and high dielectric losses. We report the pseudocapacitive behavior of BFO, which allows superior charge storage compared to the ferroelectric charge storage mechanism. The BFO electrodes show a remarkably high capacitance of 1.34 F cm⁻² in a neutral Na₂SO₄ electrolyte. The charging mechanism is discussed. The capacitive behavior is linked to the beneficial effect of high-energy ball milling (HEBM) and the use of an efficient dispersant, which facilitates charge transfer. Another approach is based on the use of conductive polypyrrole (PPy) for the fabrication of PPy-BFO composites. The choice of new polyaromatic dopants with a high charge-to-mass ratio plays a crucial role in achieving a high capacitance of 4.66 F cm⁻² for pure PPy electrodes. The composite PPy-BFO (50/50) electrodes show a capacitance of 3.39 F cm⁻², low impedance, reduced charge transfer resistance, enhanced capacitance retention at fast charging rates, and good cyclic stability due to the beneficial effect of advanced dopants, HEBM, and synergy of the contribution of PPy and BFO. Full article

Employee innovative behavior is crucial for organizations to engage in innovative activities and gain competitive advantages in the context of digital transformation. Despite many studies having focused on the relationship between leadership and employee innovative behavior, the role of digital leadership and the underlying mechanisms for employee innovative behavior remain unclear. Using the cognitive–affective processing system framework, the study investigated the dual mediating role of psychological empowerment and affective commitment between digital leadership and employee innovative behavior and the moderating role of a proactive personality in such relationships. Employing data from 359 employees, the study conducted structure equation modeling to examine the hypotheses. The results show that digital leadership influences employee innovative behavior through psychological empowerment but not affective commitment. Furthermore, a proactive personality does not moderate the direct effect of digital leadership on psychological empowerment and affective commitment or the indirect effect of digital leadership on employee innovative behavior. Theoretical and practical implications are discussed. Full article

This article proposes a comprehensive stable control strategy for the planar multi-link underactuated manipulator (PMLUM), considering several uncertainties. According to the nilpotent approximation property, the control procedure is split into two stages. In the first stage of control, we postulate the idea of model degradation, reducing the PMLUM to a planar virtual Pendubot (PVP). This occurs by controlling the active link (AL) to a specific desired position and the passive link (PL) moves along with it. When the AL moves to the desired position, the second phase of control is entered. Meanwhile, all ALs are regarded as a whole, so the PMLUM can be regarded as a mechanical arm with 2-DOF. In the second stage of control, due to the nilpotent approximation feature of the PVP, the PVP is guided to the desired angle using the iterative steering technique. Simulation experiments are carried out on active–active–passive (AAP) and active–active–active–passive (AAAP) systems under major uncertainties, which contain initial velocity and torque disturbances. The final results validate the effectiveness of the method proposed. Full article

The principle of continuity posits that some central features of primordial biocatalytic mechanisms should still be present in the genetically dependent pathway of protein synthesis, a crucial step in the emergence of life. Key bimolecular reactions of this process are catalyzed by DNA-dependent RNA polymerases, aminoacyl-tRNA synthetases, and ribosomes. Remarkably, none of these biocatalysts contribute chemically active groups to their respective reactions. Instead, structural and functional studies have demonstrated that nucleotidic α-phosphate and β-d-ribosyl 2′ OH and 3′ OH groups can help their own catalysis, a process which, consequently, has been called “substrate-assisted”. Furthermore, upon binding, the substrates significantly lower the entropy of activation, exclude water from these catalysts’ active sites, and are readily positioned for a reaction. This binding mode has been described as an “entropy trap”. The combination of this effect with substrate-assisted catalysis results in reactions that are stereochemically and mechanistically simpler than the ones found in most modern enzymes. This observation is consistent with the way in which primordial catalysts could have operated; it may also explain why, thanks to their complementary reactivities, β-d-ribose and phosphate were naturally selected to be the central components of early coding polymers. Full article

Background and Objectives: The risks of uveitis development among pediatric patients with Down syndrome (DS) remain unclear. Therefore, we aimed to determine the risk of uveitis following a diagnosis of DS. Materials and Methods: This multi-institutional retrospective cohort study utilized the TriNetX database to identify individuals aged 18 years and younger with and without a diagnosis of DS between 1 January 2000 and 31 December 2023. The non-DS cohort consisted of randomly selected control patients matched by selected variables. This included gender, age, ethnicity, and certain comorbidities. The main outcome is the incidence of new-onset uveitis. Statistical analysis of the uveitis risk was reported using hazard ratios (HRs) and 95% confidence intervals (CIs). Separate analyses of the uveitis risk among DS patients based on age groups and gender were also performed. Results: A total of 53,993 individuals with DS (46.83% female, 58.26% white, mean age at index 5.21 ± 5.76 years) and 53,993 non-DS individuals (45.56% female, 58.28% white, mean age at index 5.21 ± 5.76 years) were recruited from the TriNetX database. Our analysis also showed no overall increased risk of uveitis among DS patients (HR: 1.33 [CI: 0.89–1.99]) compared to the non-DS cohort across the 23-year study period. Subgroup analyses based on different age groups showed that those aged 0–1 year (HR: 1.36 [CI: 0.68–2.72]), 0–5 years (HR: 1.34 [CI: 0.75–2.39]), and 6–18 years (HR: 1.15 [CI: 0.67–1.96]) were found to have no association with uveitis risk compared to their respective non-DS comparators. There was also no increased risk of uveitis among females (HR: 1.49 [CI: 0.87–2.56]) or males (HR: 0.82 [CI: 0.48–1.41]) with DS compared to their respective non-DS comparators. Conclusions: Our study found no overall increased risk of uveitis following a diagnosis of DS compared to a matched control population. Full article

Research and development (R&D) is a significant driver of innovation that leads to superior performance. The present study attempts to examine the relationship between R&D intensity and a firm’s performance at both aggregate and industry levels in the emerging market of India using a battery of R&D intensity measures and stock market returns as a measure of a firm’s performance. The study was conducted on 1097 companies from six R&D-intensive industries. The Fama-French portfolio formation method was used to evaluate the stock market performance of R&D-intensive firms for both equal-weighted (EW) and value-weighted (VW) returns. The findings suggest that R&D intensity and stock returns show a positive relationship. A long–short strategy in R&D-intense firms has yielded 1.43% (t = 4.22) per month in the sample. In general, the results suggest an undervaluation of highly R&D-intensive firms that investors can exploit for above-average returns. The effect is not homogeneous across return schemes (equal-weighted and value-weighted) or across industries. R&D growth measures and R&D capital are not found to have significant impacts on stock returns. Both the market firm size and age are included as control variables, and the results reveal that the relationship is robust to these control variables. The sub-periods ranging from 2000 to 2007 and 2008 to 2019 have been considered in the present study and the results are consistent with the overall sample. The study fills the existing empirical void for R&D intensity and stock returns in relation to the emerging market of India. Full article

Red phycoerythrin (R-PE) is a highly valuable protein found in an edible seaweed, Pyropia yezoensis. It is used extensively in biotechnological applications due to its strong fluorescence and stability in diverse environments. However, the current methods for extracting and purifying R-PE are costly and unsustainable. The aim of the present study was to enhance the financial viability of the process by improving the extraction and purification of R-PE from dried P. yezoensis and to further enhance R-PE value by incorporating it into a tandem dye for molecular biology applications. A combination of ultrafiltration, ion exchange chromatography, and gel filtration yielded concentrated (1 mg·mL^–1) R-PE at 99% purity. Using purified PE and Cyanine5 (Cy5), an organic tandem dye, phycoerythrin-Cy5 (PE-Cy5), was subsequently established. In comparison to a commercially available tandem dye, PE-Cy5 exhibited 202.3% stronger fluorescence, rendering it suitable for imaging and analyzes that require high sensitivity, enhanced signal-to-noise ratio, broad dynamic range, or shorter exposure times to minimize potential damage to samples. The techno-economic analysis confirmed the financial feasibility of the innovative technique for the extraction and purification of R-PE and PE-Cy5 production. Full article

The study of shield tunnel segment flotation is crucial for controlling the precision of underground excavation projects. Based on Winkler’s beam foundation theory, the load structure method, and the equivalent continuous beam model, and by considering the mechanical and spatial conditions that cause segment flotation, a novel theoretical calculation method for cumulative flotation is proposed using a simplified equivalent stiffness model of the tunnel. Additionally, a new concept of “equivalent flotation force” is introduced. The rationality and applicability of this theoretical calculation method are verified by comparing it with on-site construction data from the Yuanjiang River Crossing Tunnel Project in Changde, Hunan Province, China. The experimental results demonstrate that the theoretical calculation closely approximates the surface deformation monitoring data of the tunnel alignment in the eastern section of the project, and their deformation patterns are similar. Near the starting shaft, there is significant settlement influenced by stratum loss due to smaller tunnel flotation, with greater settlement occurring in the upper part. However, at approximately 45 m into both sections, they enter a deformation stability zone showing significant correlation in longitudinal deformation. Through comparison and verification of on-site experiments and theoretical model analysis, we preliminarily elucidate the feasibility of this innovative cumulative flotation theoretical calculation method which provides an important theoretical basis for assessing segment flotation issues in subsequent tunnel shield construction evaluations. Full article

To assess the impact of Enchytraeidae (potworms) on the functioning of the decomposer system, knowledge of the feeding preferences of enchytraeid species is required. Different food preferences can be explained by variations in enzymatic activities among different enchytraeid species, as there are no significant differences in the morphology or anatomy of their alimentary tracts. However, it is crucial to distinguish between the contribution of microbial enzymes and the animal’s digestive capacity. Here, we computationally analyzed the endogenous digestive enzyme genes in Enchytraeus albidus. The analysis was based on RNA-Seq of COI-monohaplotype culture (PL-A strain) specimens, utilizing transcriptome profiling to determine the trophic position of the species. We also corroborated the results obtained using transcriptomics data from genetically heterogeneous freeze-tolerant strains. Our results revealed that E. albidus expresses a wide range of glycosidases, including GH9 cellulases and a specific digestive SH3b-domain-containing i-type lysozyme, previously described in the earthworm Eisenia andrei. Therefore, E. albidus combines traits of both primary decomposers (primary saprophytophages) and secondary decomposers (sapro-microphytophages/microbivores) and can be defined as an intermediate decomposer. Based on assemblies of publicly available RNA-Seq reads, we found close homologs for these cellulases and i-type lysozymes in various clitellate taxa, including Crassiclitellata and Enchytraeidae. Full article

Concerns about the differences between boys and girls in educational achievement, school careers and educational choices have existed since the last century. Despite ongoing research, we still do not have a complete picture of gender-based differences in education. In particular, there is little comparative research on how teachers and students experience and deal with gender differences in their classrooms. Therefore, this study focuses on teacher and student perspectives on gender differences in the physics classroom of Dutch upper secondary education. The data were collected through questionnaires distributed among physics teachers (N = 72) and students (N = 212). The questionnaires for students and teachers were designed to reveal their perceptions of gender differences in the classroom, focusing on student learning characteristics and teacher–student interactions. Gender differences are reported to a larger extent by teachers than by students, especially in the area of students’ learning characteristics (e.g., boys showing more talent and interest in physics, girls showing more effort and self-regulation) and some in teacher–student interactions (e.g., girls asking teachers more questions). We conclude that concerns about differences between boys and girls are still present and need further research. More work is needed to fully understand the implications of these differences, which are expected to have an important impact on classroom interventions and guidelines for teachers to use in their classrooms. Full article

PWM (pulse width modulation) is the most widely applied current conversion technology, but the high-frequency harmonics it causes have a significant negative impact on inverter system performance. This paper focuses on the three-phase T-type three-level inverter as the research object and addresses existing PWM voltage noise and midpoint potential imbalance issues by proposing an improved random SVPWM strategy, named Neutral Point Potential Balance Random Space Vector PWM (NPB−RSVPWM). The NPB−RSVPWM strategy includes three main steps: (1) introducing a midpoint potential balancing control loop to adjust the synthesis timing of the effective vectors to generate pulse signals, optimizing midpoint potential balance; (2) employing a randomly varying carrier frequency in place of the carrier used in the SVPWM strategy to generate the driving signals for switching devices; and (3) controlling the inverter through the driving pulse signals. This strategy optimizes the synthesis sequence of traditional SVPWM strategy vectors and incorporates random frequency modulation techniques. The mathematical model analyzes PWM harmonic expressions corresponding to fixed switching frequencies, and a random frequency carrier is chosen to suppress these PWM harmonics. The effective vector’s equivalent circuit is analyzed, proposing a technique for optimized vector synthesis timing. The simulation and experimental results verify that the NPB−RSVPWM technique can disperse PWM harmonic energy, reduce voltage noise, and optimize midpoint potential balance. Under the NPB−RSVPWM strategy, the line voltage spectrum becomes uniform, the maximum harmonic content is greatly reduced, and the fluctuation in the DC side midpoint potential is significantly improved. Compared with the traditional SVPWM strategy and random PWM strategy, the NPB−RSVPWM strategy has a lower voltage noise, smaller total harmonic distortion, and a more stable midpoint potential. The effectiveness and feasibility of the NPB−RSVPWM strategy are verified by simulation and experimental results. Full article

High-risk human papillomaviruses (HPVs) are the main cause of cervical, oropharyngeal, and anogenital cancers, which are all treated with definitive chemoradiation therapy when locally advanced. HPV proteins are known to exploit the host DNA damage response to enable viral replication and the epithelial differentiation protocol. This has far-reaching consequences for the host genome, as the DNA damage response is critical for the maintenance of genomic stability. HPV+ cells therefore have increased DNA damage, leading to widespread genomic instability, a hallmark of cancer, which can contribute to tumorigenesis. Following transformation, high-risk HPV oncoproteins induce chromosomal instability, or chromosome missegregation during mitosis, which is associated with a further increase in DNA damage, particularly due to micronuclei and double-strand break formation. Thus, HPV induces significant DNA damage and activation of the DNA damage response in multiple contexts, which likely affects radiation sensitivity and efficacy. Here, we review how HPV activates the DNA damage response, how it induces chromosome missegregation and micronuclei formation, and discuss how these factors may affect radiation response. Understanding how HPV affects the DNA damage response in the context of radiation therapy may help determine potential mechanisms to improve therapeutic response. Full article