Glutathione transferases (GSTs EC 2.5.1.18) are critical components of phase II metabolism, instrumental in xenobiotics’ metabolism. Their primary function involves conjugating glutathione to both endogenous and exogenous toxic compounds, which increases their solubility and enables their ejection from cells. They also play a role in the transport of non-substrate compounds and immunomodulation, aiding in parasite establishment within its host. The cytosolic GST subfamily is the most abundant and diverse in helminths, and sigma-class GST (GSTσ) belongs to it. This review focuses on three key functions of GSTσ: serving as a detoxifying agent that provides drug resistance, functioning as an immune system modulator through its involvement in prostaglandins synthesis, and acting as a vaccine antigen. Full article

Clayey soils exhibit significant volumetric changes in response to variations in water content. The swelling pressure of clayey soils is a critical parameter for evaluating the stability and performance of structures built on them, facilitating the development of appropriate design methodologies and mitigation strategies to ensure their long-term integrity and safety. We present a dataset comprising maximum swelling pressure values from 759 compacted soil samples, compiled from 16 articles published between 1994 and 2022. The dataset is classified into two main groups: 463 samples of natural clays and 296 samples of bentonite and bentonite mixtures, providing data on various types of soils and their properties. Different swelling test methods, including zero swelling, swell consolidation, restrained swell, double oedometer, free swelling, constant volume oedometer, UPC isochoric cell, isochoric oedometer and consolidometer, were employed to measure the maximum swelling pressure. The comprehensive nature of the dataset enhances its applicability for geotechnical projects. The dataset is a valuable resource for understanding the complex interactions between soil properties and swelling behavior, contributing to advancements in soil mechanics and geotechnical engineering. Full article

Tropospheric ozone (O₃) pollution can affect plant nutritional quality and secondary metabolites by altering plant biochemistry and physiology, which may lead to unpredictable effects on crop quality and resistance to pests and diseases. Here, we investigated the effects of O₃ (ambient air, Am; ambient air +80 ppb of O₃, EO₃) on the quality compounds and chemical defenses of a widely cultivated tea variety in China (Camellia sinensis cv. ‘Baiye 1 Hao’) using open-top chamber (OTC). We found that elevated O₃ increased the ratio of total polyphenols to free amino acids while decreasing the value of the catechin quality index, indicating a reduction in leaf quality for green tea. Specifically, elevated O₃ reduced concentrations of amino acids and caffeine but shows no impact on the concentrations of total polyphenols in tea leaves. Within individual catechins, elevated O₃ increased the concentrations of ester catechins but not non-ester catechins, resulting in a slight increase in total catechins. Moreover, elevated O₃ increased the emission of biogenic volatile organic compounds involved in plant defense against herbivores and parasites, including green leaf volatiles, aromatics, and terpenes. Additionally, concentrations of main chemical defenses, represented as condensed tannins and lignin, in tea leaves also increased in response to elevated O₃. In conclusion, our results suggest that elevated ground-level O₃ may reduce the quality of tea leaves but could potentially enhance the resistance of tea plants to biotic stresses. Full article

Glutamate is the major excitatory neurotransmitter in the central nervous system. Glutamatergic transmission can be mediated by ionotropic glutamate receptors (iGluRs), which mediate rapid synaptic depolarization that can be associated with Ca²⁺ entry and activity-dependent change in the strength of synaptic transmission, as well as by metabotropic glutamate receptors (mGluRs), which mediate slower postsynaptic responses through the recruitment of second messenger systems. A wealth of evidence reported over the last three decades has shown that this dogmatic subdivision between iGluRs and mGluRs may not reflect the actual physiological signaling mode of the iGluRs, i.e., α-amino-3-hydroxy-5-methyl-4-isoxasolepropionic acid (AMPA) receptors (AMPAR), kainate receptors (KARs), and N-methyl-D-aspartate (NMDA) receptors (NMDARs). Herein, we review the evidence available supporting the notion that the canonical iGluRs can recruit flux-independent signaling pathways not only in neurons, but also in brain astrocytes and cerebrovascular endothelial cells. Understanding the signaling versatility of iGluRs can exert a profound impact on our understanding of glutamatergic synapses. Furthermore, it may shed light on novel neuroprotective strategies against brain disorders. Full article

The pressing demand for novel compounds to address contemporary health challenges has prompted researchers to venture into uncharted territory, including extreme ecosystems, in search of new natural pharmaceuticals. Fungi capable of tolerating extreme conditions, known as extremophilic fungi, have garnered attention for their ability to produce unique secondary metabolites crucial for defense and communication, some of which exhibit promising clinical significance. Among these, halophilic fungi thriving in high-salinity environments have particularly piqued interest for their production of bioactive molecules. This review highlights the recent discoveries regarding novel compounds from halotolerant fungal strains isolated from various saline habitats. From diverse fungal species including Aspergillus, Penicillium, Alternaria, Myrothecium, and Cladosporium, a plethora of intriguing molecules have been elucidated, showcasing diverse chemical structures and bioactivity. These compounds exhibit cytotoxicity against cancer cell lines such as A549, HL60, and K-562, antimicrobial activity against pathogens like Escherichia coli, Bacillus subtilis, and Candida albicans, as well as radical-scavenging properties. Notable examples include variecolorins, sclerotides, alternarosides, and chrysogesides, among others. Additionally, several compounds display unique structural motifs, such as spiro-anthronopyranoid diketopiperazines and pentacyclic triterpenoids. The results emphasize the significant promise of halotolerant fungi in providing bioactive compounds for pharmaceutical, agricultural, and biotechnological uses. However, despite their potential, halophilic fungi are still largely unexplored as sources of valuable compounds. Full article

The use of decentralized wastewater treatment technologies is a reasonable solution for rural areas. As a decentralized treatment technology, the multi-soil-layering (MSL) system has recently drawn an increasing amount of attention owing to its merits, such as a high hydraulic load rate, small land area occupation, low probability of clogging, low investment, and low operation cost. This review summarizes the progress in MSL systems in the past decade, focusing on the directions of efforts for system optimization, the latest applications of MSL systems to various wastewater treatments, and the integration of MSL with other technologies. The great application potential of MSL systems is illustrated, and future research directions regarding better application of MSL systems are provided. Full article

This study presents the synthesis and electrochemical evaluation of nitrogen-doped vanadium oxide (N−V₂O₃/C) as a cathode material for aqueous zinc-ion batteries (AZIBs), using a hydrothermal method. Compared to undoped V₂O₃/C, N−V₂O₃/C exhibits enhanced electrical conductivity, capacity, and electrochemical kinetics, attributed to the incorporation of pyridinic and pyrrolic nitrogen. The initial charge–discharge cycles indicate phase transitions to amorphous vanadium oxides, enhancing conductivity. N−V₂O₃/C shows a high specific capacity of 168.4 mAh g⁻¹ at 10 A g⁻¹ and remarkable reversibility, highlighted by the transient existence of intermediate species during cycling. Optimal electrochemical performance is achieved with a vanadium-to-nitrogen molar ratio of 2:3, indicating the significant impact of the nitrogen doping concentration on the material’s efficiency. This work underscores the potential of N−V₂O₃/C as a superior cathode material for AZIBs. Full article

Meteorological conditions play a crucial role in driving outbreaks of rubber tree powdery mildew (RTPM). As the climate warms and techniques improve, rubber cultivation is expanding to higher latitudes, and the changing climate increases the RTPM risk. Rubber plantations on Hainan Island, situated on the northern margin of the tropics, have been selected as a case study to explore the meteorological mechanisms behind RTPM outbreaks quantitatively using a structural equation model, and project current and future RTPM outbreak patterns under different climate change scenarios by building predictive models based on data-driven algorithms. The following results were obtained: (1) days with an average temperature above 20 °C and days with light rain were identified as key meteorological drivers of RTPM using structural equation modeling (R² = 0.63); (2) the Bayesian-optimized least-squares boosted trees ensemble model accurately predicted the interannual variability in the historical RTPM disease index (R² = 0.79); (3) currently, due to the increased area of rubber plantations in the central region of Hainan, there is a higher risk of RTPM; and (4) under future climate scenarios, RTPM shows a decreasing trend (at a moderate level), with oscillating and sporadic outbreaks primarily observed in the central and northwest regions. We attribute this to the projected warming and drying trends that are unfavorable for RTPM. Our study is expected to enhance the understanding of the impact of climate change on RTPM, provide a prediction tool, and underscore the significance of the climate-aware production and management of rubber. Full article

The sustainable urban design of residential neighborhoods plays an important role in the efforts to achieve the sustainable development goals and alleviate the effects of climate change. This paper aims to develop a model for the sustainable urban design of residential neighborhoods, taking into account the local condition in Palestinian territories. This model is built on various international neighborhood sustainability assessment (NSA) tools, based on the review of existing assessment tools, to study the sustainability status of Palestinian neighborhoods, and to develop a sustainable indicator model for local sustainable neighborhood assessment. Computer tools like Urbano and GIS tools as well as qualitative assessment methods are used. Results from the case study showed that the satisfaction of the preferred location indicator was not sufficient to maintain its sustainability. The assessment of measured indicators found that weaknesses were almost double the count of the satisfactory indicator. Moreover, some indicators from the (NSA) tools were partially or completely met, and some gaps appeared because of the lack of strengths in the selected indicators of the international tools when used for local social, ecological and governmental aspects, and there are issues in the inclusion of economic and environmental elements in current urban configurations. The proposed local model offers valuable insights for local governments, municipalities, and construction developers. Full article

Industrial control systems are often used to assist and manage an industrial operation. These systems’ weaknesses in the various hierarchical structures of the system components and communication backbones make them vulnerable to cyberattacks that jeopardize their security. In this paper, the security of these systems is studied by employing a reinforcement learning extended attack graph to efficiently reveal the subsystems’ flaws. Specifically, an attack graph that mimics the environment is constructed for the system using the state–action–reward–state–action technique, in which the agent is regarded as the attacker. Attackers may cause the greatest amount of system damage with the fewest possible actions if they have the highest cumulative reward. The worst-case assault scheme with a total reward of 42.9 was successfully shown in the results, and the most badly affected subsystems were recognized. Full article

Soybean is a high-value food source, and the invasive weeds Mexican prickly poppy (Argemone ochroleuca) could release allelochemicals that inhibit the growth of this crop. The impact of A. ochroleuca on the germination and growth of soybean is not well documented. Therefore, the aim of this study was to evaluate the TLC profiles of different extracts of A. ochroleuca and assess the effects of extracts on the germination of soybean seeds. Shoots and roots of A. ochroleuca were weighed and 100 g of each was separately extracted with 1000 mL deionized water, hexane or acetone. Ten concentrations of water extracts ranging from 10 to 100 mL per 100 mL of deionized water and three concentrations of acetone and hexane extracts ranging from 2.5 to 7.5 g/L were separately used for seed germination bioassays. Thin-layer chromatography (TLC) analysis was used to compare the chemical profiles in the shoot and root water, and in the hexane and acetone extracts of A. ochroleuca. The highest reduction was recorded from the water extract, at 100%. The TLC profiling of A. ochroleuca addressed different classes of compounds, including alkaloids, phenolic acids and flavanoids. There is, however, a need to identify the most active phytochemicals in the suppression of germination. Full article

With the development of machine vision technology, deep learning and image recognition technology has become a research focus for agricultural product non-destructive inspection. During the ripening process, banana appearance and nutrients clearly change, causing damage and unjustified economic loss. A high-efficiency banana ripeness recognition model was proposed based on a convolutional neural network and transfer learning. Banana photos at different ripening stages were collected as a dataset, and data augmentation was applied. Then, weights and parameters of four models trained on the original ImageNet dataset were loaded and fine-tuned to fit our banana dataset. To investigate the learning rate’s effect on model performance, fixed and updating learning rate strategies are analyzed. In addition, four CNN models, ResNet 34, ResNet 101, VGG 16, and VGG 19, are trained based on transfer learning. Results show that a slower learning rate causes the model to converge slowly, and the training loss function oscillates drastically. With different learning rate updating strategies, MultiStepLR performs the best and achieves a better accuracy of 98.8%. Among the four models, ResNet 101 performs the best with the highest accuracy of 99.2%. This research provides a direct effective model and reference for intelligent fruit classification. Full article

The capacity of particulate matter (PM) to enhance and stimulate the expression of pro-inflammatory mediators has been previously demonstrated in non-antigen-presenting cells (human bronchial epithelia). Nonetheless, many proposed mechanisms for this are extrapolated from known canonical molecular pathways. This work evaluates a possible mechanism for inflammatory exacerbation after exposure to PM_2.5 (from Puerto Rico) and CuSO₄, using human bronchial epithelial cells (BEAS-2B) as a model. The induction of CIITA, MHCII genes, and various pro-inflammatory mediators was investigated. Among these, the phosphorylation of STAT1 Y701 was significantly induced after 4 h of PM_2.5 exposure, concurrent with a slight increase in CIITA and HLA-DRα mRNA levels. INFγ mRNA levels remained low amidst exposure time, while IL-6 levels significantly increased at earlier times. IL-8 remained low, as expected from attenuation by IL-6 in the known INFγ-independent inflammation pathway. The effects of CuSO₄ showed an increase in HLA-DRα expression after 8 h, an increase in STAT1 at 1 h, and RF1 at 8 h We hypothesize and show evidence that an inflammatory response due to PM_2.5 extract exposure in human bronchial epithelia can be induced early via an alternate non-canonical pathway in the absence of INFγ. Full article

The advancement of agricultural mesh technology has contributed to its improved properties. As a result, agricultural nets are widely adopted in large-scale farming applications, for example, in cereal crop farming. However, a consequence of this increased use of agricultural nets is the accumulation of large amounts of waste. The current paper focuses on the recycling of agricultural nets used in wrapping straw bales to develop additives and fillers in cement composites. The research details an analysis of the use of waste agricultural meshes as an ingredient in cement composites. Six test series of different mixtures were conducted. In the first four series, agricultural waste was utilised as an additive in a composite comprising aggregate and cement slurry (the amounts of wasted nets were 20, 40, 60, and 80 kg/m³). In the last test series, the recyclate utilised comprised a mixture of cement slurry and waste only. The composites were subjected to standard tests and thermal resistance tests. The results showcased that that the addition of a net worsened the workability of the concrete mixture, and with increasing amounts of addition, the consistency of the mixture could change from liquid to dense plastic. The flexural strength of the composite decreased with increasing amounts of recyclate. In subsequent test series, the flexural strength value was lower than that of the control (3.93 MPa), from 7.38% (3.64 MPa) for the composite with 20 kg/m³ of recyclate to 37.66% (2.45 MPa) for the composite with of 80 kg/m³ recyclate. The flexural strength value of the net-filled composite without aggregate was very high (10.44 MPa), where the value obtained for the control composite was 62.36% lower. The results of the compressive strength test showed a decrease in this parameter with increasing amounts of additive. The value assessed for the control composite was 27.99 MPa. As expected, the composite that had no aggregate and consisted of only recycled filler had the lowest compressive strength. The value of this parameter was 13.07 MPa, and it was 53.31% lower than that of the control composite. The results of the tests of resistance to temperatures were similar to those recorded for the composites with polypropylene fibres. All composites demonstrated a significant decrease in their compressive and flexural strength after annealing. SEM imaging showed that the net fibres were closely bonded to the cement stone. Finally, it was concluded that recyclates performed best as fillers in lightweight composites with a low density, low absorption, high flexural strength, and satisfactory compressive strength. Full article

Natural products hold immense potential for drug discovery, yet many remain unexplored in vast libraries and databases. In an attempt to fill this gap and meet the growing demand for effective drugs, this study delves into the promising world of ent-kaurane diterpenoids, a class of natural products with huge therapeutic potential. With a dataset of 570 ent-kaurane diterpenoids obtained from the literature, we conducted an in silico analysis, evaluating their physicochemical, pharmacokinetic, and toxicological properties with a focus on their therapeutic implications. Notably, these natural compounds exhibit drug-like properties, aligning closely with those of FDA-approved drugs, indicating a high potential for drug development. The ranges of the physicochemical parameters were as follows: molecular weights—288.47 to 626.82 g/mol; number of heavy atoms—21 to 44; the number of hydrogen bond donors and acceptors—0 to 8 and 1 to 11, respectively; the number of rotatable bonds—0 to 11; fraction Csp3—0.65 to 1; and TPSA—20.23 to 189.53 Ų. Additionally, the majority of these molecules display favorable safety profiles, with only 0.70%, 1.40%, 0.70%, and 46.49% exhibiting mutagenic, tumorigenic, reproduction-enhancing, and irritant properties, respectively. Importantly, ent-kaurane diterpenoids exhibit promising biopharmaceutical properties. Their average lipophilicity is optimal for drug absorption, while over 99% are water-soluble, facilitating delivery. Further, 96.5% and 28.20% of these molecules exhibited intestinal and brain bioavailability, expanding their therapeutic reach. The predicted pharmacological activities of these compounds encompass a diverse range, including anticancer, immunosuppressant, chemoprotective, anti-hepatic, hepatoprotectant, anti-inflammation, antihyperthyroidism, and anti-hepatitis activities. This multi-targeted profile highlights ent-kaurane diterpenoids as highly promising candidates for further drug discovery endeavors. Full article

Background: On 18 June 2022, Moderna and Pfizer-BioNTech COVID-19 vaccines were authorized under an Emergency Use Authorization by the United States Food and Drug Administration to prevent severe coronavirus disease in children six months to four years of age. Despite approval of the COVID-19 vaccinations for young children, there remain ongoing challenges reaching widespread coverage due to parental decision-making. Parental decision-making plays a pivotal, yet understudied, role governing vaccine adoption among this priority demographic. Methods: This cross-sectional analysis examined COVID-19 vaccine intentions for 320 predominately Hispanic parents of two to five-year-olds attending Miami-Dade County childcare programs in Florida USA, several months following the June 2022 emergency authorization. Parent’s self-reported survey data encompassed vaccine choices and rationales, social determinants of health, and parent immigrant status. Data analyses illustrate the associations between parent decision-making and these variables. Regression modeling and tests of independence identified predicting factors for parental vaccine decision-making. Results: Only 25% of parents intended to vaccinate their young child, while 34% resisted and 41% felt unsure, despite 70% personal vaccination rates. Household income under $25,000, identifying as a migrant, or testing COVID-19-positive significantly predicted unsure decision-making. The majority of hesitant groups expressed concerns around side effects (20%), safety (2.9%), and sufficiency of vaccine knowledge (3.3%). Conclusions: In this sample, the predominance of parents were unsure and resistant rather than accepting of having their child vaccinated despite emergency approval of the pediatric vaccine. Associations and predictive factors are examined. Full article

This research examines the behavior of electrochemical passivation and the chemistry of surface films on 654SMO super austenitic stainless steel and C276 nickel-based alloy in simulated condensates from flue gas desulfurization in power plant chimneys. The findings indicate that the resistance to polarization of the protective film on both materials initially rises and then falls with either time spent in the solution or the potential of anodic polarization. Comparatively, 654SMO exhibits greater polarization resistance than C276, indicating its potential suitability as a chimney lining material. Mott–Schottky analysis demonstrates that the density of donors in the passive film formed on 654SMO exceeds that on C276, potentially due to the abundance of Fe oxide in the passive film, which exhibits the characteristics of an n-type semiconductor. The primary components of the passive films on both materials are Fe oxides and Cr oxides. The formation of a thin passive film on C276 in the simulated condensates is a result of the low Gibbs free energy of nickel oxide and low Cr content. The slower diffusion coefficient of point defects leads to the development of a thicker and more compact passive film on the surface of 654SMO. Full article

The success of the Internet of Things (IoT) has driven the development, among others, of many different software architectures for producing, processing, and analyzing heterogeneous data. In many cases, IoT applications share common features, such as the use of a platform or middleware, also known as message broker, that collects and manages data traffic between endpoints. However, in general, data processing is very dependent on the case study (sensors that send temperature data, drones that send images, etc.). Thus, the applications responsible for receiving and processing data, which we call consumers, have to be built ad hoc, since some of their elements have to be specially configured to solve specific needs of the case study. This paper presents Flextory, a software factory tool to make it easier for IoT developers to automatically construct configurable consumer applications, which we call FLEX-consumers. Flextory guides developers through the process of generating Java consumers by selecting some desired features such as, for instance, the particular communication protocol to be used. This way, the developer only has to concentrate on designing the algorithm to process the data. In short, the use of Flextory will result in consumer applications with configurable behavior, namely FLEX-consumers, that can connect to a messaging server (for example RabbitMQ) and process the received messages. Full article

Trichotillomania (TTM) is a psychiatric disorder involving chronic, recurrent urges to pull out one’s own hair, arising frequently in childhood and early adolescence. This disorder predominantly affects women and has a high co-morbidity with many other psychiatric conditions. Currently, the etiology is unknown, which makes treating TTM extremely difficult. While the epidemiology and proposed causes will be discussed briefly, the primary purpose of this review is to provide a comprehensive, updated summary of the psychological and pharmacological management options for patients diagnosed with TTM, as new clinical trial data for previously studied and novel treatments have become available within the last decade. Of the behavioral interventions, cognitive behavioral therapy (CBT) and habit reversal training (HRT) have demonstrated the greatest improvements in hair-pulling severity, with HRT showing the most efficacy for long-term maintenance of progress. Pharmacological therapies with the most success include Olanzapine, Clomipramine, and N-Acetylcysteine, though larger replication studies are needed. Selective serotonin reuptake inhibitors (SSRIs) have yielded inconsistent results in clinical trials, yet they are frequently prescribed for TTM. Naltrexone, Dronabinol, and Inositol are emerging as potential treatments, but the results suggest that additional studies are needed. Future research directions include larger placebo-controlled pharmacological trials, exploring the efficacy of combined behavioral and pharmacological approaches compared to monotherapy, and delving into the potential genetic and neurochemical contributions that may underlie TTM. Full article

The aim of this paper is to conduct a literature review of the existing nexus between conspiracy theories and populist politics. Most of the literature considering the political nature of conspiracy theories has focused mainly on individual action and electoral choices, hence setting aside the agency of political leaders that deliberately resort to these tales to mobilise supporters. On the contrary, conspiracy theories are increasingly moving away from extremist politics to enter the institutional political arena and become part and parcel of the political narratives and strategies of institutional figures. Against this backdrop, the present work offers a new approach to investigate the connection between populist conspiracy theories and conspiracist populism and attempts to explain how conspiracist populism works and what its potential impact on contemporary democracies is. The analysis of the literature offers some theoretical insights to explore the specific case of the presidency of Kais Saied in Tunisia, which has been labelled as a form of constitutional populism integrating conspiracy theories. The inquiry on the Tunisian case demonstrates that conspiracy theories can represent both tactics and framings for populists in power, and, if democratic checks and balances are weak enough, they can lead to the erosion of democracy itself. Full article

This study presents an evaluation of seventeen newly produced recombinant trivalent chimeric proteins (containing the same immunodominant fragment of SAG1 and SAG2 of Toxoplasma gondii antigens, and an additional immunodominant fragment of one of the parasite antigens, such as AMA1, GRA1, GRA2, GRA5, GRA6, GRA7, GRA9, LDH2, MAG1, MIC1, MIC3, P35, and ROP1) as a potential alternative to the whole-cell tachyzoite lysate (TLA) used in the detection of infection in small ruminants. These recombinant proteins, obtained by genetic engineering and molecular biology methods, were tested for their reactivity with specific anti-Toxoplasma IgG antibodies contained in serum samples of small ruminants (192 samples of sheep serum and 95 samples of goat serum) using an enzyme-linked immunosorbent assay (ELISA). The reactivity of six recombinant trivalent chimeric proteins (SAG1-SAG2-GRA5, SAG1-SAG2-GRA9, SAG1-SAG2-MIC1, SAG1-SAG2-MIC3, SAG1-SAG2-P35, and SAG1-SAG2-ROP1) with IgG antibodies generated during T. gondii invasion was comparable to the sensitivity of TLA-based IgG ELISA (100%). The obtained results show a strong correlation with the results obtained for TLA. This suggests that these protein preparations may be a potential alternative to TLA used in commercial tests and could be used to develop a cheaper test for the detection of parasite infection in small ruminants. Full article

Magnetron-sputtered WS₂ composite thin films are solid lubricants with excellent performances. However, the low hardness of the WS₂ thin films necessitates the further improvement of their wear resistance. For this purpose, an effective strategy is to alternately deposit or code posit WS₂ and a hard phase, such as TiB₂, to form hard lubricant thin films. Herein, a TiB₂ thin film was prepared under the same conditions as those used for depositing the WS₂ thin film with a dense structure and excellent tribological properties. Because of the high deposition energy of high-power impulse magnetron sputtering (HiPIMS), the TiB₂ thin film possesses a dense structure and leather-like flat surface (hardness = 24.17 GPa). The friction coefficient of the film under different loads ranges between 0.6 and 0.8. The wear rate of the thin film increases with load, mainly because of fatigue wear and abrasive wear. Under high loads, obvious furrow-like wear marks are observed. At different sliding frequencies, except 8 Hz, the friction coefficient of the film ranges from 0.6 to 0.8. The main wear mode is fatigue wear, particularly at increasing sliding frequencies. Although the film possesses a relatively high friction coefficient, its wear resistance is excellent (minimum wear rate = 1.96 × 10⁻⁶ mm³/(N·m)). Full article