In this work, we present a novel approach for improving the energy resolution from particles impinging on the interstrip regions of silicon strip detectors. We employed three double-sided strip detectors from the GRIT array and a triple $\alpha 5pt$-source under laboratory conditions. The results showed that the interstrip resolution depends not only on the impinging side but also on whether it is a P- or an N-interstrip. We obtained the interstrip energy resolution down to $0.4\%$, and, depending on the scenario, the resolution was enhanced by a factor of 2. We believe that this new rotation method allows for the possibility of applying particle identification methods on interstrip events, which in most cases are dismissed during data recording. Full article

In the context of “dual carbon”, restrictions on carbon emissions have attracted widespread attention from researchers. In order to solve the issue of the insufficient exploration of the synergistic emission reduction effects of various low-carbon policies and technologies applied to multiple microgrids, we propose a multi-microgrid electricity cooperation optimization scheduling strategy based on stepped carbon trading, a hydrogen-doped natural gas system and P2G–CCS coupled operation. Firstly, a multi-energy microgrid model is developed, coupled with hydrogen-doped natural gas system and P2G–CCS, and then carbon trading and a carbon emission restriction mechanism are introduced. Based on this, a model for multi-microgrid electricity cooperation is established. Secondly, design optimization strategies for solving the model are divided into the day-ahead stage and the intraday stage. In the day-ahead stage, an improved alternating direction multiplier method is used to distribute the model to minimize the cooperative costs of multiple microgrids. In the intraday stage, based on the day-ahead scheduling results, an intraday scheduling model is established and a rolling optimization strategy to adjust the output of microgrid equipment and energy purchases is adopted, which reduces the impact of uncertainties in new energy output and load forecasting and improves the economic and low-carbon operation of multiple microgrids. Setting up different scenarios for experimental validation demonstrates the effectiveness of the introduced low-carbon policies and technologies as well as the effectiveness of their synergistic interaction. Full article

Sedimentation is an important property of colloidal systems that should be considered when designing pharmaceutical formulations. In pharmaceutical applications, sedimentation is normally described using Stokes’ law, which assumes laminar flow of fluid. In this work we studied swelling and hydration of spherical cross-linked amorphous starch microspheres in pure water, solutions of sodium chloride, and in pH-adjusted aqueous solutions. We demonstrated that Reynolds numbers obtained in these experiments correspond to the transition regime between the laminar flow and the turbulent flow and, hence, expressions based on the non-Stokes drag coefficient should be used for calculations of sedimentation velocity from known density or for assessment of density from observed sedimentation velocity. The density of starch microparticles hydrated in water was about 1050 kg/m³, while densities obtained from experiment with other liquids were dependent on the liquids’ densities. The data indicate that the swelling of the cross-linked starch microparticles as characterized by their densities is not sensitive to pH and salt concentration in the studied range of these parameters. Full article

Wilms tumor (WT), the most prevalent type of renal cancer in children, exhibits overall survival rates exceeding 90%. However, chemotherapy resistance, which occurs in approximately 10% of WT cases, is a major challenge for the treatment of WT, particularly for advanced-stage patients. In this study, we aimed to discover potential mutation markers and drug targets associated with chemotherapy resistance in advanced-stage WT. We performed exome sequencing to detect somatic mutations and molecular targets in 43 WT samples, comprising 26 advanced-stage WTs, of which 7 cases were chemotherapy-resistant. Our analysis revealed four genes (ALPK2, C16orf96, PRKDC, and SVIL) that correlated with chemotherapy resistance and reduced disease-free survival in advanced-stage WT. Additionally, we identified driver mutations in 55 genes within the chemotherapy-resistant group, including 14 druggable cancer driver genes. Based on the mutation profiles of the resistant WT samples, we propose potential therapeutic strategies involving platinum-based agents, PARP inhibitors, and antibiotic/antineoplastic agents. Our findings provide insights into the genetic landscape of WT and offer potential avenues for targeted treatment, particularly for patients with chemotherapy resistance. Full article

Social–emotional learning (SEL) is a rapidly growing field of research that has garnered significant attention in recent years. Each facet of SEL research in fields such as education, mental health, and developmental research has used specific methodologies and terms in their narrow research focus. In education specifically, where the most SEL research has been produced, many frameworks have implementation requirements. The lack of a framework focused on overarching themes without implementation requirements prevents the fields from coming together to compile and compare research and progress to create parent-, adult-, or mental health-specific SEL programs. This paper provides a conceptual analysis of SEL, aimed at clarifying the concept and deconstructing its various facets. This framework is needed to acknowledge the many different terms and skills for the same principle while also narrowing down definitions for clarity. The resulting framework can be used as a basis for future research, practice, and policy discussions in the field. Full article

We develop a quantum theory based on macroscopic quantum electrodynamics to research the resonance energy transfer (RET) between a chiral donor and acceptor. It differs from the previous Green function approach which needs specific boundary conditions to obtain an analytical solution for calculating the RET rate. Our theory can combine the finite-difference time-domain (FDTD) method, which gives a simple and efficient semi-analytical approach, to evaluate the chiral RET rate in an arbitrary plasmonic nanosystem. Applying our theory to the systems of chiral molecules 3-methylcyclopentanone (3MCP) near the achiral/chiral plasmonic nanostructures, the RET process, which is divided into nondiscriminatory and discriminatory parts, is investigated. We find that plasmon will enhance both nondiscriminatory and discriminatory rates compared to the absence of plasmonic nanostructure, but the plasmon supported by chiral nanostructure contributes more to the discriminatory rate. The ratio of discriminatory to nondiscriminatory rates in the system consisting of 3MCP and chiral plasmonic structure is five-fold compared to the system consisting of 3MCP and achiral plasmonic structure. The phenomena can be attributed to the chiral electric-magnetic coupling. Our findings are important in understanding the achiral and chiral electric-magnetic interaction and designing chiral light-harvesting and sensing devices. Full article

Lushan Yunwu tea (LSYWT) is a famous green tea in China. However, the effects of intercropping tea with flowering cherry on the overall aroma of tea have not been well understood. In this study, headspace solid-phase microextraction (HS-SPME) coupled with gas chromatography–mass spectrometry (GC–MS) was used for analysis. A total of 54 volatile compounds from eight chemical classes were identified in tea samples from both the intercropping and pure-tea-plantation groups. Principal component analysis (PCA), orthogonal partial least-squares discriminant analysis (OPLS-DA), and odor activity value (OAV) methods combined with sensory evaluation identified cis-jasmone, nonanal, and linalool as the key aroma compounds in the intercropping group. Benzaldehyde, α-farnesene, and methyl benzene were identified as the main volatile compounds in the flowering cherry using headspace solid-phase microextraction/gas chromatography–mass spectrometry (HS-SPME/GC–MS). These findings will enrich the research on tea aroma chemistry and offer new insights into the product development and quality improvement of LSYWT. Full article

Subsoiling tillage breaks up the shallow plow layer and thickened plow pan resulting from prolonged crop rotation, thus enhancing the soil tillage layer environment and fostering crop growth. However, these changes in tillage practices are not accompanied by corresponding advancements in irrigation technology. Therefore, this study compared drip irrigation (DI) and micro-sprinkler irrigation (MS) with three watering levels (H, M, L) based on soil water content (70%, 60%, 50% of field capacity) against traditional surface irrigation (CK, 70%FC) to find the most suitable irrigation approach for subsoiling wheat fields. This study found that adjusting irrigation methods and regimes significantly impacted wheat growth and yield. Drip irrigation boosts winter wheat grain yield, harvest index, biomass transfer amount, biomass transfer rate, nitrogen accumulation, nitrogen use efficiency, and nitrogen harvest index significantly compared to surface and micro-sprinkler methods. Drip irrigation, notably the DI-M treatment, significantly enhances winter wheat grain yield by 28.7% compared to CK. Drip irrigation produced optimal results when soil water levels decreased to 60% of the field capacity. This suggests adopting a combination of DI, with irrigation initiated at 60% of field capacity, for enhanced wheat production and resource efficiency. Full article

The aerodynamic performance of wings degrades severely at low Reynolds number; lift often becomes non-linear, while drag increases significantly, caused by large extents of separation. Consequently, a non-conventional wing design approach is implemented to assess its ability to enhance performance. The design methodology is that of wing segmentation, where the wing is divided into spanwise panels that can be separated, thereby yielding small gaps between the panels. A moderate aspect ratio wing comprised of four separate wing panels was manufactured and wind tunnel tested through a Re range from 40,000 to 80,000. Force balance data and surface flow visualization were used to characterize performance. The results indicate that segmentation is effective in significantly augmenting efficiency at Reynolds numbers at which the fused wing (i.e., no gaps) shows large extents of open separation. Drag is greatly reduced, while lift is increased, and stall is delayed. The benefit of segmentation was noted to diminish at higher Re where the fused wing’s performance improves markedly. Wing segmentation could find application in micro-unmanned-aerial-vehicle and drone design. Further study would entail the effects of AR and the number of spanwise panels on performance. Full article

The mechanical behavior associated with the flow of ore-rock bulk materials is an important factor leading to the instability and failure of the shaft wall of the ore storage section in ore passes. It is of great significance for accurately understanding the stability failure characteristics of the shaft wall in the ore storage section in the ore-drawing process to understand the flow characteristics and internal mechanical transfer mechanism of ore-rock bulk. The flow characteristics, contact compactness, stress distribution characteristics, and contact force probability distribution of the ore-rock bulk are analyzed by the discrete element method, which realizes the quantitative characterization of the damage degree of ore-rock flow and reveals the damage mechanism of the shaft wall in the storage section of the ore pass. The results show that (1) in the process of ore-rock particle flow in the ore pass storage section, the macroscopic flow pattern of ore-rock particles changes from a “—” shape to a “V” shape, and the friction between ore-rock particles, particles, and the ore-pass wall is an important reason for the change of the macroscopic flow pattern; (2) the probability distribution of contact force strength between the particles decreases exponentially in the whole ore-drawing process, in which the strong force chains play a major role in the stability of the bulk system; and (3) the overpressure frequency and overpressure coefficient could be used to quantitatively characterize the wall damage degree under the action of ore-rock flow. The dynamic lateral pressure fluctuates periodically in exponential form and decreases, and the dynamic load formed by the ore-rock flow mainly acts on the lower part of the ore storage section. Full article

Immunotherapy is a clinically effective method for treating tumors. Manganese can activate the cGAS-STING signaling pathway and induce an anti-tumor immune response. However, its efficacy is hindered by non-specific distribution and low uptake rates. In this study, we employed microfluidic technology to design and develop an innovative preparation process, resulting in the creation of a novel manganese lipid nanoparticle (LNM). The lipid manganese nanoparticle produced in this process boasts a high manganese payload, excellent stability, the capacity for large-scale production, and high batch repeatability. LNM has effectively demonstrated the ability to activate the cGAS-STING signaling pathway, induce the production of pro-inflammatory cytokines, and inhibit tumor development. Notably, LNM does not require combination chemotherapy drugs or other immune activators. Therefore, LNM presents a safe, straightforward, and efficient strategy for anti-tumor immune activation, with the potential for scalable production. Full article

A field study was conducted to assess the effect of tillage systems (TSs) and manure rates (MRs) on sunflower growth and yield at the University of Limpopo Experimental Farm (Syferkuil) which is on sandy loam soils and University of Venda Experimental Farm (UNIVEN) clayey soils, both located in Limpopo Province of South Africa for 2021/2022 and 2022/2023 cropping seasons. The experimental design was a split plot with three replications. The main plot was the tillage treatments: conventional (CON) and in-field rainwater harvesting (IRWH), while the subplots were the manure treatments: viz. poultry and cattle manures at rates of 20 and 35 t ha⁻¹⁰, plus a control (no manure application). The IRWH is a tillage technique that collects rainwater on a 2 m wide runoff strip into the 1 m wide basin where it infiltrates deep into the soil beyond the evaporation zone but is available for crop use. The results revealed that at Syferkuil IRWH had a significant increase (p < 0.05) on grain yield, head diameter, head dry matter and aboveground dry matter yield in both cropping seasons, whereas at UNIVEN, the significant increase was obtained on grain yield, head diameter, aboveground dry matter, plant height and stem girth during both cropping seasons. The effect of manure rate significantly increased with the application rate, with poultry manure at the highest rate of 35 t ha⁻¹ significantly recording high mean values of grain yield, head diameter, head dry matter, aboveground dry matter, plant height and stem girth at both sites during the two cropping seasons. The increase in leaf area index and 100 seed weight by IRWH and manure rate application varied across the growing stages and cropping seasons with no consistent trend. At Syferkuil, TS and MR interaction was significant on head diameter and on aboveground dry matter at flowering stage in the first cropping season, whereas at UNIVEN, it was significant on head diameter in the first cropping season. Therefore, these results suggest that IRWH combined with poultry manure (35 t ha⁻¹) can be adopted to improve sunflower crop yield under similar management and environmental conditions. In the absence of poultry manure, farmers may opt to use cattle manure at a rate of 35 t ha⁻¹ for better improved yield. Full article

Traditional fluorescent anti-counterfeiting materials usually exhibit fixed-wavelength excitation patterns and monochromatic luminescence, which are extremely easy to be counterfeited and have low security. Therefore, there is an urgent need to develop multi-mode fluorescent materials with enhanced security to address this issue. Here, SrAl₂O₄:1%Eu,2%Dy@Y₂O₃:Eu³⁺ core-shell structured phosphors were prepared via a sol-gel method. Coating SrAl₂O₄:Eu,Dy with Y₂O₃:Eu³⁺ red phosphor did not significantly change the crystal structure of SrAl₂O₄. Under UV excitation at 254 nm, SrAl₂O₄:1%Eu,2%Dy@Y₂O₃:Eu³⁺ exhibited red emission at 613 nm (⁵D₀→⁷F₂ transition of Eu³⁺), and a strong green afterglow was observed after removing the UV irradiation. However, blue-green emission at 496 nm was observed under UV excitation at 365 nm, followed by green afterglow upon removal of the light source. Varying the content of the Y₂O₃:Eu³⁺ shell yielded different emissions and afterglows. The prepared samples are sensitive to the excitation wavelength and duration and have multimodal luminescence properties, which can be used for anti-counterfeiting patterns. The outcomes in this work indicate that the phosphor is a promising fluorescent material for anti-counterfeiting. Full article

Violence against paramedics is widely recognized as a serious, but underreported, problem. While injurious physical attacks on paramedics are generally reported, non-physical violence is less likely to be documented. Verbal abuse can be very distressing, particularly if the harassment targets personal or cultural identities, such as race, ethnicity, gender, or sexual orientation. Leveraging a novel, point-of-event reporting process, our objective was to estimate the prevalence of harassment on identity grounds against paramedics in a single paramedic service in Ontario, Canada, and assess its potentially differential impact on emotional distress. In an analysis of 502 reports filed between 1 February 2021 and 28 February 2022, two paramedic supervisors independently coded the free-text narrative descriptions of violent encounters for themes suggestive of sexism, racism, and homophobia. We achieved high inter-rater agreement across the dimensions (k = 0.73–0.83), and after resolving discrepant cases, we found that one in four violent reports documented abuse on at least one of the identity grounds. In these cases, paramedics were 60% more likely to indicate being emotionally distressed than for other forms of violence. Our findings offer unique insight into the type of vitriol paramedics experience over the course of their work and its potential for psychological harm. Full article

Most of the licensed vaccines against SARS-CoV-2 target spike proteins to induce viral neutralizing antibodies. However, currently prevalent SARS-CoV-2 variants contain many mutations, especially in their spike proteins. The development of vaccine antigens with conserved sequences that cross-react with variants of SARS-CoV-2 is needed to effectively defend against SARS-CoV-2 infection. Given that viral infection is initiated in the respiratory mucosa, strengthening the mucosal immune response would provide effective protection. We constructed a mucosal vaccine antigen using the papain-like protease (PLpro) domain of non-structural protein 3 of SARS-CoV-2. To potentiate the mucosal immune response, PLpro was combined with human beta-defensin 2, an antimicrobial peptide with mucosal immune adjuvant activity, and Co1, an M-cell-targeting ligand. Intranasal administration of the recombinant PLpro antigen conjugate into C57BL/6 and hACE2 knock-in (KI) mice induced antigen-specific T-cell and antibody responses with complement-dependent cytotoxic activity. Viral challenge experiments using the Wuhan and Delta strains of SARS-CoV-2 provided further evidence that immunized hACE2 KI mice were protected against viral challenge infections. Our study shows that PLpro is a useful candidate vaccine antigen against SARS-CoV-2 infection and that the inclusion of human beta-defensin 2 and Co1 in the recombinant construct may enhance the efficacy of the vaccine. Full article

The first half of 2022 saw the publication of several major research advances in image-based models and artificial intelligence applications to optimize treatment strategies for high-grade gliomas, the deadliest brain tumors. We review them and discuss the barriers that delay their entry into clinical practice; particularly, the small sample size and the heterogeneity of the study designs and methodologies used. We will also write about the poor and late palliation that patients suffering from high-grade glioma can count on at the end of life, as well as the current legislative instruments, with particular reference to Italy. We suggest measures to accelerate the gradual progress in image-based models and end of life care for patients with high-grade glioma. Full article

This qualitative study aimed to understand men’s social connectedness in later life in Portugal focusing on their perceptions, obstacles, strategies, and impact on well-being. The sample included 104 older Portuguese men over 65 years of age (M_age = 70.76 years). The qualitative data were the direct transcriptions of the answers given by participants to the electronic interview using thematic analysis. Findings revealed six overarching themes encompassing 18 subcategories: definitions of social connectedness (social support, community identity, mental health promotion, use of community structures), difficulties/obstacles in maintaining social connectedness (ageism, lack of initiative, physical limitations, psychological traits, resources), strategies/actions or resources to establish social connections (use of technology, use of community groups, leisure and sport activities, church/religion), negative impact of difficulties in establishing relevant social connections (mental health, physical health, relationships), positive actions from being socially connected (positive prescriptions to promote social connectedness), and concerns from being socially disconnected (health risks). These findings indicate that the lack of social connectedness creates social vulnerability in later life, and social support is needed to ensure safer aging among older men. Full article

Canonical autophagy is an evolutionarily conserved process that forms double-membrane structures and mediates the degradation of long-lived proteins (LLPs). Noncanonical autophagy (NCA) is an important alternative pathway involving the formation of microtubule-associated protein 1 light chain 3 (LC3)-positive structures that are independent of partial core autophagy proteins. NCA has been defined by the conjugation of ATG8s to single membranes (CASM). During canonical autophagy and NCA/CASM, LC3 undergoes a lipidation modification, and ATG16L1 is a crucial protein in this process. Previous studies have reported that the WDR domain of ATG16L1 is not necessary for canonical autophagy. However, our study found that WDR domain deficiency significantly impaired LLP degradation in basal conditions and slowed down LC3-II accumulation in canonical autophagy. We further demonstrated that the observed effect was due to a reduced interaction between ATG16L1 and FIP200/WIPI2, without affecting lysosome function or fusion. Furthermore, we also found that the WDR domain of ATG16L1 is crucial for chemical-induced NCA/CASM. The results showed that removing the WDR domain or introducing the K490A mutation in ATG16L1 significantly inhibited the NCA/CASM, which interrupted the V-ATPase-ATG16L1 axis. In conclusion, this study highlights the significance of the WDR domain of ATG16L1 for both canonical autophagy and NCA functions, improving our understanding of its role in autophagy. Full article

Thermochromic (TC) smart windows are a leading passive building design strategy. Vanadium dioxide (VO₂), hydrogel and TC-Perovskite glazing, which constitute the main categories of TC materials, modulate different wavelength regions. Although numerous studies have reported on these TC glazings’ energy-saving potential individually, there is a lack of data comparing their energy efficiencies. Moreover, their suitability as an alternative to dynamic solar shading mechanisms remains unexplored. Using building energy simulation, this study found that a hydrogel glazing with broadband thermochromism can save more energy (22–24% savings on average) than opaque roller shades (19–20%) in a typical office in both New York and Hong Kong. VO₂ glazing performed comparably to translucent roller shades (14–16% savings), except when used in poorly daylit conditions. TC-Perovskite was a poor replacement for roller shades (~2% savings). The window-to-wall ratio (WWR) that allowed both energy savings and optimal natural light penetration was also identified for each glazing. Hydrogel glazing demonstrated both energy and daylight efficiency in Hong Kong’s cooling-dominated climate when used in 40–50% WWR configurations. In New York’s colder conditions, VO₂ glazing did so for higher WWRs (50–70%). Roller shades could also achieve simultaneous energy savings and visual comfort, but only for highly glazed facades (up to 80%). Full article

Air pollution is a severe problem in the modern world. Urbanization, industrialization, and traffic emit air pollutants such as carbon monoxide (CO), nitrous oxides (NOx), hydrocarbons (HCs), and particulate matter into the environment. Plants can absorb air pollutants through stomata. They adversely affect the various metabolic and physiological processes of plant species. This review describes the impact of air pollution on plant health, morphologically, physiologically, and genetically, and the tolerance ability of plants located along roadside areas. Many morphological effects, like chlorosis, necrosis, leaf area, stomatal clogging, plant productivity, leaf falling, and reduction in flower yield, are observed due to the influence of air pollution. Air pollutants also damage the DNA and affect the biochemicals of the plants, as well as pH, relative water content (RWC), simple sugar, ascorbic acid (AA), total chlorophyll content (TCH), proline, and polyamines. Some plants located under pollution stress can mitigate air pollution. Plants with higher APTI values are more tolerant of air pollution, while those with the lowest APTI values can be used as an indicator of the rate of air pollution. There is much morphological, biochemical, and DNA damage noted in this review. Different strategies can be used to diagnose the effects of air pollution in the future and develop green belts to mitigate air pollution in pollution-stressed areas. Full article

Reducing restrictive practices toward individuals with intellectual and developmental disabilities is a globally recognized imperative and human rights priority. This paper presents a novel tool called LibRe for assessing and reducing restrictive practices. This tool involves an instrumental multistage design and collaboration between professionals, individuals with disabilities, family members, and experts from different fields. It addresses diverse restrictive practices in five key domains: physical or mechanical, chemical or pharmacological, structural, relational, and practices related to contexts and supports. It addresses practices that are pertinent to the Spanish context and that existing tools have not covered. Embedded as a step within an organizational approach, LibRe fosters organizational transformation and provides resources to achieve outcomes within reduction plans for restrictive practices. In total, 156 teams comprising 585 professionals, 64 people with disabilities, and 44 family members responded to the tool. In terms of evidence for internal structure validity, the oblique five-factor model exhibited an adequate fit through confirmatory factor analysis, along with satisfactory reliability indices, according to ordinal alpha and omega. Users positively appraised the tool’s usefulness and identified its strengths and challenges. Although further research is needed, preliminary evidence frames LibRe as a useful resource for practice and research. Full article

Non-structural members, such as roofs and ceilings, become affixed to main beams that are known as structural members. When such main beams experience bending or compressive forces that lead to lateral buckling, non-structural members may act to restrain the resulting lateral buckling deformation. Nevertheless, neither Japanese nor European guidelines advocate for the utilization of non-structural members as lateral buckling stiffeners for beams. Additionally, local buckling ensues near the bolt apertures in the beam–roof folded plate connection due to the torsional deformation induced by the lateral buckling of the H beam, thereby reducing the rotational stiffness of the roof folded plate to a percentage of its ideal stiffness. This paper conducts torsional experiments on roof folded plates, and with various connection methods between these plates and the beams, to comprehend the deformation mechanism of roof folded plates and the relationship between their rotational stiffness and the torsional moment. Then, the relationship between the demand values against restraining the lateral buckling of the main beam and the experimentally determined bearing capacity of the roof folded plate is elucidated. Results indicate the efficacy of utilizing the roof folded plate as a continuous brace. The lateral buckling design capacity of H beams that are continuously stiffened by roof folded plates is elucidated via application of a connection method that ensures joint stiffness between the roof folded plate and the beam while using Japanese and European design codes. Full article