The sustainable microwave (MW) synthesis of hydroxyapatite (HAp) from decarbonized eggshells was investigated. Decarbonization of eggshells, as a natural source of calcium carbonate (CaCO₃), was carried out in the current study at ambient conditions to reduce the footprint of CO₂ emissions on our environment where either calcination or acidic direct treatments of eggshells produce CO₂ emissions, which is a major cause for global warming. Eggshell decarbonization was carried out via the chemical reaction with sodium hydroxide (NaOH) alkaline solution in order to convert eggshell waste into calcium hydroxide (Ca(OH)₂) and simultaneously store CO₂ as a sodium carbonate (Na₂CO₃) by-product which is an essential material in many industrial sectors. The produced Ca(OH)₂ was mixed with ammonium dihydrogen phosphate (NH₄H₂PO₄) reagent at pH~11 before being subjected to MW irradiation at 2.45 GHz frequency for 5 min using 800 Watts to prepare HAp. The prepared Nano-HAp was characterized using X-ray diffraction (XRD) where the crystal size was ~28 nm using the Scherrer equation. The elongated rod-like nano-HAp crystals were characterized using scanning electron microscopy (SEM) equipped with dispersive energy X-ray spectroscopy (EDS), Fourier transform infrared spectroscopy (FTIR), and transmission electron microscopy (TEM). MW synthesis of decarbonized eggshells is considered as a sustainable and environmentally friendly route to produce promising bioceramics such as nano-HAp. Concurrently, decarbonization of eggshells offers the ability to store CO₂ as a high value-added Na₂CO₃ material. Full article

The film temperature distribution of the valve plate pair in axial piston pumps affects its lubrication, leakage, and friction. In order to investigate the film temperature distribution of the valve plate pair in axial piston pumps, a test platform was constructed including three displacement sensors for the oil film thickness and eleven thermocouples for the film temperature distribution of the valve plate pair. An accurate film shape model of the valve plate pair was built according to the three-point film thickness test data. Based on the film shape model, the film temperature model of the valve plate pair was developed considering the viscous oil temperature characteristics, the energy loss caused by leakage and viscous friction in the film, and the heat conduction among the oil, cylinder block, and valve plate. The influence of different swash plate tilt angles and operating pressures on the valve plate film temperature was studied. The test results indicate that the film temperature of the valve plate pair increases as the working pressure and swash plate tilt angle increase. The theoretical and experimental absolute errors of the film temperature in the circumferential range [−60°, 60°] of the valve plate high-pressure side are less than 3.5 °C. As the swash plate tilt angle varies from 12° to 16° and working pressure from 3 MPa to 7 MPa, the minimum film thickness position and the maximum temperature point move accordingly in the circumferential range [−15°, 5°] of the valve plate pair. Full article

DNA repair pathways play a critical role in genome stability, but in eukaryotic cells, they must operate to repair DNA lesions in the compact and tangled environment of chromatin. Previous studies have shown that the packaging of DNA into nucleosomes, which form the basic building block of chromatin, has a profound impact on DNA repair. In this review, we discuss the principles and mechanisms governing DNA repair in chromatin. We focus on the role of histone post-translational modifications (PTMs) in repair, as well as the molecular mechanisms by which histone mutants affect cellular sensitivity to DNA damage agents and repair activity in chromatin. Importantly, these mechanisms are thought to significantly impact somatic mutation rates in human cancers and potentially contribute to carcinogenesis and other human diseases. For example, a number of the histone mutants studied primarily in yeast have been identified as candidate oncohistone mutations in different cancers. This review highlights these connections and discusses the potential importance of DNA repair in chromatin to human health. Full article

The mechanical recycling of discarded plastic products as resources for environmental preservation has recently gained research attention. In this context, it is necessary to use waste materials for fiber-reinforced thermoplastics (FRTP). Glass and carbon fibers are often damaged by shear and compression during melt-forming processes. To achieve a sustainable society, it is necessary for thermal recycling to produce minimal to no residue and for mechanical recycling to maintain the length of fibers used in FRTP to preserve their performance as a reinforcing agent. Aramid fibers (AFs) do not shorten during the melt-molding process, and their composites have excellent impact strength. On the other hand, plastics reinforced with glass or carbon fibers are reported to have a superior strength and modulus of elasticity compared to aramid fibers. This study investigates the dispersion of a carbon nanofiber (CNF), a whisker, as the third component in aramid-fiber-reinforced polypropylene (PP/AF). The results and discussion sections demonstrate how the dispersion of CNF in PP/AF can enhance the mechanical properties of injection-molded products without compromising their impact resistance. The proposed composition will have excellent material recyclability and initial mechanical properties compared to glass-fiber-reinforced thermoplastics. Full article

Digital health apps have become a staple in daily life, promoting awareness and providing motivation for a healthier lifestyle. With an already overwhelmed healthcare system, digital therapies offer relief to both patient and physician alike. One such planned digital therapy application is the incorporation of an emotion recognition model as a tool for therapeutic interventions for people with autism spectrum disorder (ASD). Diagnoses of ASD have increased relatively rapidly in recent years. To ensure effective recognition of expressions, a system is designed to analyze and classify different emotions from facial landmarks. Facial landmarks combined with a corresponding mesh have the potential of bypassing hurdles of model robustness commonly affecting emotion recognition from images. Landmarks are extracted from facial images using the Mediapipe framework, after which a custom mesh is constructed from the detected landmarks and used as input to a graph convolution network (GCN) model for emotion classification. The GCN makes use of the relations formed from the mesh along with the special distance features extracted. A weighted loss approach is also utilized to reduce the effects of an imbalanced dataset. The model was trained and evaluated with the Aff-Wild2 database. The results yielded a 58.76% mean accuracy on the selected validation set. The proposed approach shows the potential and limitations of using GCNs for emotion recognition in real-world scenarios. Full article

In elite sports, athletic excellence demands meticulous performance preparation and a sound health status. This paper overviews the current propositions and applications of pervasive computing and data analytics and our vision on how they should be used in future frameworks to contribute to the optimal balance of athletes’ performance and health requirements. Two main areas will be discussed. The first area is Sports Performance Optimization, in which we consider interesting recent advancements in data analytics for performance improvement, equipment design, and team member recruitment and selection. We will also briefly discuss how the betting industry has been relaying and developing sports analytics. The second area is Athlete’s Wellness and Wellbeing, which will discuss how wearables and data analytics have been used to assess physical activity and sedentary behavior profiles, sleep and circadian rhythm, nutrition and eating behavior, menstrual cycles, and training/performance readiness. In the final part of this paper, we argue that a critical issue for managers to enhance their decision making is the standardization of acquired information and decision-making processes, while introducing an adaptable, personalized approach. Thus, we present and discuss new theoretical and practical approaches that could potentially address this problem and identify precision medicine as a recommended methodology. This conceptualization involves the integration of pervasive computing and data analytics by employing predictive models that are constantly updated with the outcomes from monitoring tools and athletes’ feedback interventions. This framework has the potential to revolutionize how athletes’ performance and well-being are monitored, assessed, and optimized, contributing to a new era of precision in sports science and medicine. Full article

Piezoelectric materials such as PVDF and its copolymers have been widely studied in different areas and with promising applications, such as haptic feedback actuators or deformation sensors for aided-mobility scenarios. To develop PVDF-based solutions, different protocols are reported in the literature; however, a toxic and harmful solvent is commonly used (dymethilformamide (DMF)). In the present study, a non-toxic solvent (dymethilsulfoxide (DMSO)) is used to dissolve PVDF powder, while a specific ionic liquid (IL), [PMIM][TFSI], is used to enhance piezoelectric properties. A PVDF/IL thin film is characterized. The physical material characterization is based on optical analysis (to ensure the sample’s homogeneity) and on mechanical linear behaviour (Young’s modulus of 144 MPa and yield stress of 9 MPa). Meanwhile, a chemical analysis focuses on the phase modifications introduced by the addition of IL ($\beta$ phase increase to 80% and a degree of crystallinity, $\chi$, of 30%). All the results obtained are in good agreement with the literature, which indicates that the proposed experimental protocol is suitable for producing PVDF-based thin films for biomedical applications. Full article

This study explores the impact of China’s low-carbon city policy on employment using a quasi-natural experiment approach based on microdata from A-share listed companies (2007–2021). The findings indicate a statistically significant positive effect on employment levels, with an average increase of 7.27% in pilot compared to non-pilot cities. This boost in employment is primarily linked to green innovation, improved financing conditions, and increased sales activities. The policy disproportionately benefits high-skilled workers and positively affects employment in sales, research and development, and management while having a lesser impact on low-skilled and production workers. The employment gains are particularly significant in non-polluting sectors, regions with high marketization, and in the eastern areas of China. This study underscores the complex interplay between environmental policies and labor markets, emphasizing the need for skill differentiation in policy frameworks. Full article

Accurately determining the energy values of ingredients is crucial for meeting energy requirements and achieving maximum production performance of animals. This study was conducted to measure the available energy values of three expanded soybean meals (ESBMs) for Arbor Acres male broilers from 14 to 16 day and 28 to 30 day using the difference method. A corn–soybean basal diet was formulated, and test diets were developed with 25% ESBMs as substitutes for energy-yielding ingredients. A completely randomized design was used for determining heat production and energy balance of broilers in 12 open-circuit respiration chambers, with six replicates per group. Prior to measurement, four (14 to 16 day) or two (28 to 30 day) birds per chamber were given a 4-day adaption to diets and chambers. The period lasted for 3 days to determine the apparent metabolizable energy (AME), nitrogen balance, gas exchanges, and heat production. Broilers fed test diets with 25% ESBM exhibited higher nitrogen intake (p < 0.05), nitrogen excreta (p < 0.05), and increased energy deposition as protein irrespective of age (p < 0.05). Furthermore, results showed that AME, nitrogen corrected AME (AMEn), and net energy (NE) values of 3 ESBMs averaged 10.48, 8.93, and 6.88 MJ/kg for broilers from 14 to 16 day, while averaged 11.91, 10.42, and 6.43 MJ/kg for broilers from 28 to 30 day. Broilers from 28 to 30 day showed significantly higher AMEn values but lower NE/AME values of ESBMs compared with those from 14 to 16 day (p < 0.05). Therefore, age-dependent energy values of a single ingredient should be considered in feed formulations to optimize economic returns. Full article

The Stevia rebaudiana Germplasm Bank at the University of Cordoba, Colombia, plays a pivotal role in conserving and efficiently utilizing the genetic variability of this species. Despite safeguarding promising genotypes with valuable traits, such as late flowering or a significant diterpenoid glycoside content, there is a need for an efficient mass propagation protocol for elite genotypes. This study aims to develop efficient in vitro micropropagation protocols for three elite S. rebaudiana genotypes (L020, L102, and Morita II). The methods employed various combinations of cytokinins and auxins following organogenesis protocols. The results showed that optimal shoot multiplication (17.3 shoots per explant) for L020 was achieved when cultures were grown on a basal medium MS supplemented with 1 μM 6-benzylaminopurine (BAP). For L102, optimal shoot multiplication (18.5 shoots per explant) was achieved in MS supplemented with 1 μM BAP and 0.5 μM naphthalene acetic acid (NAA), while for Morita II, the best treatment was an MS supplemented with 2 μM BAP and 0.5 μM NAA, producing 16.4 shoots per explant. This study successfully achieved micropropagation for promising S. rebaudiana genotypes, highlighting the significant impact of genotype on tissue culture, particularly in shoot multiplication. Developing a successful micropropagation system is crucial for the conservation and improvement of S. rebaudiana, with significant implications for its future use and performance. Full article

External hoof characteristics, balance, and conformation have been extensively studied in horses; however, mules remain understudied in these aspects. This study evaluated the size, shape, and symmetry of untrimmed and unshod forelimb hooves, compared the symmetry between forelimb hooves and stratified external forelimb hoof measurements based on the body condition score of mules raised in the foothill plains of northern Thailand. The forelimb hooves of 38 mules were photographed and 33 parameters, including angular and linear measurements, were analyzed. A multivariate analysis was used to explore the influence of sex, age, and body condition scores (BCS) on angular, linear, and area parameters. Additionally, one-way ANOVA followed by Tukey’s test was used to compare these parameters across different BCS groups. Despite the absence of shoeing and trimming, these mules exhibited optimal left–right forelimb hoof symmetry, with no significant (p < 0.05) differences in: outer wall length and inner wall length (OWL–IWL: Left 0.11 ± 0.66 cm; Right −0.12 ± 0.43 cm); sole length and sole width (SL^S–SW: Left 1.65 ± 0.76 cm; Right 1.46 ± 0.89 cm); dorsal hoof wall length and heel length (DHWL–HL: Left 4.00 ± 0.80 cm; Right 3.81 ± 0.72 cm); and frog length and frog width (FL–FW: Left 3.88 ± 1.13 cm; Right 3.82 ± 0.18 cm). However, significant (p < 0.05) differences were observed within each body condition score group for forelimb hoof measurements for DHWL, IWL, heel separation (HS), heel bulb distance (HBD), SW, FW, and FL, while sex and age had no significant differences across the study variables. These findings provide valuable insights into mule welfare and management, contributing to understanding of the interplay between overall health and hoof conformation in the study area. Full article

The need for sustainable development in the context of pesticide use has been recognized by the European Union. The “Farm to Fork Strategy” indicates a goal of 50% reduction in pesticide use by 2030. To address this challenge, we used the concept of ionic liquids to modify known resistance inducers, i.e., a group of substances whose action is indicated as an alternative to fungicides. A new, patented substance developed by us, which is a choline 3,5-dichlorosalicylate, has been tested in the context of its use in sugar beet cultivation with the aim of controlling Cercospora leaf spot (CLS). The results suggest that the use of this substance in combination with one fungicide treatment reduces disease infection and produces yields very similar to the use of a standard protection program assuming the use of two fungicides. Such results provide the basis for further development of 3,5-dichlorosalicylate in terms of its use in agriculture. Thanks to its use, it was possible to resign from one fungicide treatment, while maintaining protection against CLS and yields at the same level as for the full fungicide protection program. Such an approach is in line with European Union policies. Full article

Conventional global navigation satellite system receivers typically employ a two-step positioning procedure (2SP) by first independently estimating the synchronization parameters and then using these parameters to solve a system of superdeterministic equations derived from multilateration to accomplish positioning. Direct position estimation (DPE) has emerged as a promising alternative that utilizes a single-step procedure to obtain the maximum likelihood estimate of a position. This approach has been shown to effectively mitigate biases incurred by the second estimation step in 2SP. However, for code-division multiple-access systems, the pseudo-orthogonality of the spreading codes causes the estimation problem not to be mapped to a perfectly orthogonal space. Additionally, the cross-correlation interference between satellites renders the maximum likelihood invariant theory untenable in the first estimation step of the 2SP. This study presents the derivation of the Cramér–Rao bound constraint for both the 2SP and DPE, evaluating the performance degradation of the 2SP compared to that of the DPE with the consideration of cross-correlation. Furthermore, a more stringent result is proven, indicating that the 2SP is not as asymptotically efficient as the DPE in all scenarios. The derived bounds are validated using realistic scenarios, and the root-mean-square error performance of the respective maximum likelihood estimators is compared. Full article

Carbon peaking and carbon neutrality goals have put forward new requirements for the development of sustainable energy. As an important part of the energy system, the power system plays an important role in achieving sustainable energy development. Future power systems will be sustainable, with a high proportion of renewable energy such as photovoltaic and wind power. With advancements in technology and the sustainable development of power systems, the construction costs of wind power, photovoltaics, and other renewable energy sources will continue to decline. At the same time, in order to cope with the uncertainty of renewable energy, more flexible resources need to be built. Under a high proportion of sustainable energy penetration, the utilization rate of flexible resources is low, which will lead to an increase in adjustment costs. Economic issues have an important impact on the development of new power systems, and power system construction will in turn affect social and economic development. Therefore, it is necessary to analyze changing trends in electricity prices in the process of power system sustainability from a quantitative perspective, so as to provide guidance for future planning. In view of the above problems, this paper takes Gansu Province as an example, predicts future power installation trends, by analyzing the power system form evolution, and uses production operation simulation technology to determine the power generation and consumption situation. On this basis, the costs of various power supplies and power grids are calculated, and trends in electricity prices in Gansu Province are forecast. Full article

Technology readiness levels (TRLs) is a well-established and widely used approach for defining the readiness of new technology. It assesses technology maturity against specific benchmarks, ranging from level 1 (concept) to level 9 (market solution). Although this is a useful classification service that allows us to establish a common language, there are cases where we find that this conceptual approach cannot adequately highlight the maturity of certain innovative endeavors and effectively steer their development to higher TRLs. We will present an empirical case where the TRL approach presented a critical shortcoming in highlighting the true and effective readiness of a specific technological development and could not suggest the next natural step in ascending the maturity ladder. We will seek to generalize for the case of co-creation at large, analyze why co-creation may be poorly serviced by the current TRL model, and suggest an amendment that would allow the observed shortcomings of the traditional TRL approach to be overcome and its use extended into such co-creative settings, thus allowing stakeholders to enhance the effectiveness and impact of their collaborative innovation efforts. Full article

Background: Effective identification and management in the early stages of sepsis are critical for achieving positive outcomes. In this context, neutrophil-reactive intensity (NEUT-RI) emerges as a promising and easily interpretable parameter. This study aimed to assess the predictive value of NEUT-RI in diagnosing sepsis and to evaluate its prognostic significance in distinguishing 28-day mortality outcomes. Materials: This study is a secondary, retrospective, observational analysis. Clinical data upon ICU admission were collected. We enrolled septic patients and a control group of critically ill patients without sepsis criteria. The patients were divided into subgroups based on renal function for biomarker evaluation with 28-day outcomes reported for septic and non-septic patients. Results: A total of 200 patients were included in this study. A significant difference between the “septic” and “non-septic” groups was detected in the NEUT-RI plasma concentration (53.80 [49.65–59.05] vs. 48.00 [46.00–49.90] FI, p < 0.001, respectively). NEUT-RI and procalcitonin (PCT) distinguished between not complicated sepsis and septic shock (PCT 1.71 [0.42–12.09] vs. 32.59 [8.83–100.00], <0.001 and NEUT-RI 51.50 [47.80–56.30] vs. 56.20 [52.30–61.92], p = 0.005). NEUT-RI, PCT, and CRP values were significantly different in patients with “renal failure”. NEUT-RI and PCT at admission in the ICU in the septic group were higher in patients who died (58.80 [53.85–73.10] vs. 53.05 [48.90–57.22], p = 0.005 and 39.56 [17.39–83.72] vs. 3.22 [0.59–32.32], p = 0.002, respectively). Both NEUT-RI and PCT showed a high negative predictive value and low positive predictive value. Conclusions: The inflammatory biomarkers assessed in this study offer valuable support in the early diagnosis of sepsis and could have a possible role in anticipating the outcome. NEUT-RI elevation appears particularly promising for early sepsis detection and severity discrimination upon admission. Full article

Presently, antimicrobial resistance is of great risk to remarkable improvements in health conditions and infection management. Resistance to various antibiotics has been considered a great obstacle in their usage, necessitating alternative strategies for enhancing the antibacterial effect. Combination therapy has been recognized as a considerable strategy that could improve the therapeutic influence of antibacterial agents. Therefore, the aim of this study was to combine the antibacterial action of compounds of natural origin like fusidic acid (FA) and cinnamon essential oil (CEO) for synergistic effects. A distinctive nanoemulsion (NE) was developed using cinnamon oil loaded with FA. Applying the Box–Behnken design (BBD) approach, one optimized formula was selected and integrated into a gel base to provide an FA-NE-hydrogel for optimal topical application. The FA-NE-hydrogel was examined physically, studied for in vitro release, and investigated for stability upon storage at different conditions, at room (25 °C) and refrigerator (4 °C) temperatures, for up to 3 months. Ultimately, the NE-hydrogel preparation was inspected for its antibacterial behavior using multidrug-resistant bacteria and checked by scanning electron microscopy. The FA-NE-hydrogel formulation demonstrated a pH (6.32), viscosity (12,680 cP), and spreadability (56.7 mm) that are acceptable for topical application. The in vitro release could be extended for 6 h, providing 52.0%. The formulation was stable under both test conditions for up to 3 months of storage. Finally, the FA-NE-hydrogel was found to inhibit the bacterial growth of not only Gram-positive but also Gram-negative bacteria. The inhibition was further elucidated by a scanning electron micrograph, indicating the efficiency of CEO in enhancing the antibacterial influence of FA when combined in an NE system. Full article

The exchange of sensitive information between power distribution networks (PDNs) and urban transport networks (UTNs) presents a difficulty in ensuring privacy protection. This research proposes a new collaborative operation method for a coupled system. The scheme takes into account the schedulable capacity of electric vehicle charging stations (EVCSs) and locational marginal prices (LMPs) to handle the difficulty at hand. The EVCS hosting capacity model is built and expressed as the feasible area of charging power, based on AC power flow. This model is then used to offer information on the real schedulable capacity. By incorporating the charging loads into the coupling nodes between PDNs and UTNs, the issue of coordinated operation is separated and becomes equal to the optimal problem involving charging loads. Based on this premise, the most efficient operational cost of PDNs is transformed into a comparable representation of cost information in PDNs. This representation incorporates LMP information that guides charging decisions in UTNs. The suggested collaborative scheduling methodology in UTNs utilises the collected projection information from the static traffic assignment (STA) to ensure data privacy protection and achieve non-iterative calculation. Numerical experiments are conducted to illustrate that the proposed method, which uses a smaller amount of data, achieves the same level of optimality as the coordinated optimisation. Full article

The high transport characteristics of AlGaN/GaN heterostructures are critical components for high-performance electronic and radio-frequency (RF) devices. We report the transport characteristics of AlGaN/GaN heterostructures grown on a high-resistivity (HR) Si(111) substrate, which are unevenly distributed in the central and edge regions of the wafer. The relationship between the composition, stress, and polarization effects was discussed, and the main factors affecting the concentration and mobility of two-dimensional electron gas (2DEG) were clarified. We further demonstrated that the mechanism of changes in polarization intensity and scattering originates from the uneven distribution of Al composition and stress in the AlGaN barrier layer during the growth process. Furthermore, our results provide an important guide on the significance of accomplishing 6 inch AlGaN/GaN HEMT with excellent properties for RF applications. Full article

In understudied regions of the world, beekeeper records can provide valuable insights into changes in pollinator population trends. We conducted a questionnaire survey of 116 beekeepers in a mountainous area of Western Nepal, where the native honeybee Apis cerana cerana is kept as a managed bee. We complemented the survey with field data on insect–crop visitation, a household income survey, and an interview with a local lead beekeeper. In total, 76% of beekeepers reported declines in honeybees, while 86% and 78% reported declines in honey yield and number of beehives, respectively. Honey yield per hive fell by 50% between 2012 and 2022, whilst the number of occupied hives decreased by 44%. Beekeepers ranked climate change and declining flower abundance as the most important drivers of the decline. This raises concern for the future food and economic security of this region, where honey sales contribute to 16% of total household income, and where Apis cerana cerana plays a major role in crop pollination, contributing more than 50% of all flower visits to apple, cucumber, and pumpkin. To mitigate further declines, we promote native habitat and wildflower preservation, and using well-insulated log hives to buffer bees against the increasingly extreme temperature fluctuations. Full article

Ocular exposure to particulate matter (PM) causes local inflammation; however, the influence of neutrophils on PM-induced ocular inflammation is still not fully understood. In this study, we constructed a system to investigate the role of PM in ocular inflammation using a co-culture of human corneal epithelial cells (HCE-T) and differentiation-induced neutrophils (dHL-60). To investigate whether HCE-T directly endocytosed PM, we performed a holographic analysis, which showed the endocytosis of PM in HCE-T. The cytokines and chemokines produced by HCE-T were measured using an ELISA. HCE-T treated with PM produced IL-6 and IL-8, which were inhibited by N-Acetyl-L-cysteine (NAC), suggesting the involvement of ROS. Their co-culture with dHL-60 enhanced their production of IL-6, IL-8, and MCP-1. This suggests an inflammatory loop involving intraocular corneal epithelial cells and neutrophils. These cytokines and chemokines are mainly regulated by NF-κB. Therefore, this co-culture system was examined in the presence of an IKK inhibitor known to downregulate NF-κB activity. The IKK inhibitor dramatically suppressed the production of these factors in co-culture supernatants. The results suggest that the inflammatory loop observed in the co-culture is mediated through ROS and the transcription factor NF-κB. Thus, the co-culture system is considered a valuable tool for analyzing complex inflammations. Full article