The pile foundations of offshore wind turbines face serious problems from scour damage. This study takes offshore wind turbine monopile foundations as the research object and proposes an innovative anti-scour device for the protection net. A numerical simulation research method based on CFD-DEM was used to model the local scour of the pile foundation and protection net. The validity of the numerical model was verified by comparing the simulation results of the local scour of the pile foundation under the condition of clear water scour and the results of the flume test. The permeability rate was defined to characterize the overwatering of the protection net, and numerical simulations were performed for protection nets with permeability in the range of 0.681 to 0.802. The flow field perturbations, changes in washout pit morphology, and changes in washout depth development due to the protective netting were also analyzed. It was found that the protection net can effectively reduce the flow velocity around the pile, cut down the intensity of the submerged water in front of the pile, and provide scouring protection. Finally, the analysis and summary of the protection efficiency of the different protection nets revealed that the protection efficiency within the nets was consistently the highest. On the outside of the net, the protection efficiency is poor at a small permeability rate but increases with an increasing permeability rate. Full article

Surface preparation is an important step in adhesive technology. A variety of abrasive, chemical, or concentrated energy source treatments are used. The effects of these treatments vary due to the variety of factors affecting the final strength of bonded joints. This paper presents the results of an experimental study conducted to determine the feasibility of using fiber laser surface treatments in place of technologically and environmentally cumbersome methods. The effect of surface modification was studied on three materials: aluminum EN AW-1050A and aluminum alloys EN AW-2024 and EN AW-5083. For comparison purposes, joints were made with sandblasted and laser-textured surfaces and those rolled as reference samples for the selected overlap variant, glued with epoxy adhesive. The joints were made with an overlap of 8, 10, 12.5, 14, and 16 mm, and these tests made it possible to demonstrate laser processing as a useful technique to reduce the size of the overlap and achieve even higher load-bearing capacity of the joint compared to sandblasting. A comparative analysis was also carried out for the failure force of the adhesive bond and the failure energy. The results show the efficiency and desirability of using lasers in bonding, allowing us to reduce harmful technologies and reduce the weight of the bonded structure. Full article

The accurate calculation of natural frequencies is important for vibration and earthquake analyses of structural frames. For this purpose, it is necessary to discretize each beam or column of the frame into one or more smaller elements. The required number of elements per member increases when the frame’s modal shapes have wavelengths similar to the beam lengths. This paper presents a method that reduces the number of elements needed for a precise calculation. This is achieved by implementing a straightforward local correction to the kinetic and elastic energy of certain elements, resulting in a substantial decrease in error. The validity of this method is demonstrated through a range of examples, from simple canonical cases to more realistic ones. Additionally, the paper discusses the unique features of this method and examines its relationship with other approaches. Full article

Developing guidelines for designing robot-inclusive spaces has been challenging and resource-intensive, primarily relying on physical experiments and observations of robot interactions within the built environment. These conventional methods are often costly, time-consuming, and labour-intensive, demanding manual intervention. To address these limitations, this study explores the potential of using digital twins as a promising solution to offer detailed insights, reducing the dependence on physical experiments for studying robot-built environment interactions.Although the concept of digital twins is popular in many domains, the use of digital twins for this specific problem has not been explored yet. A novel methodology for assessing existing built environment guidelines by incorporating them as an architectural digital twin asset within robot simulation software is proposed in this regard. By analysing the digital interactions between robots and the architectural digital twin assets in simulations, the compatibility of the environment with robots is evaluated, ultimately contributing to enhancing these guidelines to be robot-inclusive. The ultimate goal is to create environments that are not only inclusive but also readily accessible to Autonomous Mobile Robots (AMRs). With this objective, the proposed methodology is tested on robots of different specifications to understand the robots’ interactions with different architectural digital twin environments and obstacles. The digital twin effectively demonstrates the capability of the proposed approach in assessing the robots’ suitability for deployment in the simulated environments. The gained insights contribute to improved comprehension and strengthen the existing design guidelines. Full article

Optical fiber sensors are extensively employed for their unique merits, such as small size, being lightweight, and having strong robustness to electronic interference. The above-mentioned sensors apply to more applications, especially the detection and monitoring of vital signs in medical or clinical. However, it is inconvenient for daily long-term human vital sign monitoring with conventional monitoring methods under the uncomfortable feelings generated since the skin and devices come into direct contact. This study introduces a non-invasive surveillance system that employs an optical fiber sensor and advanced deep-learning methodologies for precise vital sign readings. This system integrates a monitor based on the MZI (Mach–Zehnder interferometer) with LSTM networks, surpassing conventional approaches and providing potential uses in medical diagnostics. This could be potentially utilized in non-invasive health surveillance, evaluation, and intelligent health care. Full article

The occurrence of an axlebox bearing ring raceway defect is an inevitable and commonly observed phenomenon in railway wheels. It not only leads to surface damage but also poses the potential threat of further damage and degradation, thereby increasing the risks associated with running safety and maintenance costs. Hence, it becomes imperative to detect raceway defects at an early stage to mitigate safety hazards and reduce maintenance efforts. In this study, the focus lies in investigating the effectiveness of vibration-based detection techniques for identifying raceway defects in high-speed train axlebox bearing systems. To achieve this, a dynamic model that accurately represents the coupling dynamics between the vehicle and the track is developed. This model incorporates various dynamic factors, such as traction transmission, gear transmission, and track geometry irregularities. By using the comprehensive dynamic model, the dynamic responses of the axlebox can be accurately calculated. The proposed methodology primarily revolves around analysing the vertical vibrations of the axlebox caused by raceway defects in both the time and frequency domains. Additionally, an envelope analysis using a developed band-pass filter is also employed. The results obtained from this study clearly demonstrate the successful detection of raceway defects in a more realistic vehicle model, thereby providing an efficient approach for the detection of axlebox bearing raceway defects. Consequently, this research contributes significantly to the field of high-speed train systems and paves the way for enhanced safety and maintenance practices. Full article

The paper concerns a nonlinear second-order system of coupled PDEs, having the principal part in divergence form and subject to in-homogeneous dynamic boundary conditions, for both $\theta (t,x)$ and $\phi (t,x)$. Two main topics are addressed here, as follows. First, under a certain hypothesis on the input data, $f_{{}_1}$, $f_{{}_2}$, $w_{{}_1}$, $w_{{}_2}$, $\alpha$, $\xi$, ${\theta }_0$, ${\alpha }_0$, ${\phi }_0$, and ${\xi }_0$, we prove the well-posedness of a solution $\theta ,\alpha ,\phi ,\xi$, which is $\left(\theta (t,x),\alpha (t,x)\right)\in W_p^{1,2}\left(Q\right)\times W_p^{1,2}\left(\Sigma \right)$, $\left(\phi (t,x),\xi (t,x)\right)\in W_{\nu }^{1,2}\left(Q\right)\times W_p^{1,2}\left(\Sigma \right)$, $\nu =min\{q,\mu \}$. According to the new formulation of the problem, we extend the previous results, allowing the new mathematical model to be even more complete to describe the diversity of physical phenomena to which it can be applied: interface problems, image analysis, epidemics, etc. The main goal of the present paper is to develop an iterative scheme of fractional-step type in order to approximate the unique solution to the nonlinear second-order system. The convergence result is established for the new numerical method, and on the basis of this approach, a conceptual algorithm, alg-frac_sec-ord_u+varphi_dbc, is elaborated. The benefit brought by such a method consists of simplifying the computations so that the time required to approximate the solutions decreases significantly. Some conclusions are given as well as new research topics for the future. Full article

Headspace solid-phase microextraction, combined with gas chromatography–mass spectrometry and partial least squares discriminant analysis, was adopted to study the rule of change in volatile organic compounds (VOCs) for domestic and imported fishmeal during storage with different freshness grades. The results showed that 318 kinds of VOCs were detected in domestic fishmeal, while 194 VOCs were detected in imported fishmeal. The total relative content of VOCs increased with storage time, among which acids and nitrogen-containing compounds increased significantly, esters and ketones increased slightly, and phenolic and ether compounds were detected only in domestic fishmeal. Regarding the volatile base nitrogen, acid value, pH value, and mold counts as freshness indexes, the freshness indexes were significantly correlated with nine kinds of VOCs (p < 0.05) through the correlation analysis. Among them, volatile base nitrogen had a significant correlation with VOCs containing nitrogen, acid value with VOCs containing carboxyl group and hydrocarbons, pH value with acids which could be used to adjust pH value, and mold counts with part of acids adjusting pH value and VOCs containing nitrogen. Due to the fact that the value of all freshness indexes increased with freshness degradation during storage, based on volatile base nitrogen and acid value, the fishmeal was divided into three freshness grades, superior freshness, corrupting, and completely corrupted. By using partial least squares discriminant analysis, this study revealed the differences in flavor of the domestic and imported fishmeal during storage with different freshness grades, and it identified four common characteristic VOCs, namely ethoxyquinoline, 6,7,8,9-tetrahydro-3H-benzo[e]indole-1,2-dione, hexadecanoic acid, and heptadecane, produced by the fishmeal samples during storage, as well as the characteristic VOCs of fishmeal at each freshness grade. Full article

(1) Background: Parenteral nutrition (PN) is a technique used for the administration of nutrients to patients for whom traditional routes cannot be used. It is performed using solutions with extremely complex compositions, which can give rise to a large number of interactions. These interactions can impact their stability and put the patient’s life at risk. The aim of this study is to determine how changes in composition and storage protocol affect the stability of NP solutions. (2) Methods: Twenty-three samples were prepared according to routine clinical practice, with modifications to the concentration of some components. The samples were stored at room temperature (RT) and refrigerated (4 °C). Measurements of the droplet diameter, pH, density and viscosity were performed for both storage protocols on days 1, 3, 10 and 14. (3) Results: The samples with the lowest concentration of lipids (PN13-17) and proteins (PN18-22) showed a larger droplet diameter than the rest of the samples throughout the experiments. The USP limits were exceeded for some of the measurements of these sample groups. The pH density and viscosity remained relatively constant under the conditions studied. (4) Conclusions: The PN samples were considered stable and safe for administration under real-world conditions, but the samples with the lowest concentrations of lipids and proteins showed a tendency towards emulsion instability. Full article

Cirsium japonicum Fisch. ex DC. (CF) and Cirsium setosum (Willd.) MB (CS) are commonly used clinically to stop bleeding and eliminate carbuncles. Still, CF is mainly used for treating inflammation, while CS favors hemostasis. Therefore, the present study used UHPLC-MS to analyze the main chemical constituents in CF-CS extract. We optimized the extraction process using single-factor experiments and response surface methodology. Afterward, the hemostatic and anti-inflammatory effects of CF-CS extract were investigated by determining the clotting time in vitro, the bleeding time of rabbit trauma, and the induction of rabbit inflammation using xylene and lipopolysaccharide. The study of hemostatic and anti-inflammatory effects showed that the CF-CS, CF, and CS extract groups could significantly shorten the coagulation time and bleeding time of rabbits compared with the blank group (p < 0.01); compared with the model group, it could dramatically inhibit xylene-induced ear swelling in rabbits and the content of TNF-α, IL-6, and IL-1β in the serum of rabbits (p < 0.01). The results showed that combined CF and CS synergistically increased efficacy. CF-CS solved the problem of the single hemostatic and anti-inflammatory efficacy of a single drug, which provided a new idea for the research and development of natural hemostatic and anti-inflammatory medicines. Full article

Visual field (VF) testing dates back to fifth century B.C. It plays a pivotal role in the diagnosis, management, and prognosis of retinal and neurological diseases. This review summarizes each of the different VF tests and perimetric methods, including the advantages and disadvantages and adherence to the desired standard diagnostic criteria. The review targets beginners and eye care professionals and includes history and evolution, qualitative and quantitative tests, and subjective and objective perimetric methods. VF testing methods have evolved in terms of technique, precision, user-friendliness, and accuracy. Consequently, some earlier perimetric techniques, often still effective, are not used or have been forgotten. Newer technologies may not always be advantageous because of higher costs, and they may not achieve the desired sensitivity and specificity. VF testing is most often used in glaucoma and neurological diseases, but new objective methods that also measure response latencies are emerging for the management of retinal diseases. Given the varied perimetric methods available, clinicians are advised to select appropriate methods to suit their needs and target disease and to decide on applying simple vs. complex tests or between using subjective and objective methods. Newer, rapid, non-contact, objective methods may provide improved patient satisfaction and allow for the testing of children and the infirm. Full article

The tree species Salix caprea shows high adaptability to different habitat conditions and is economically valuable as a woody crop for biomass production. Moreover, S. caprea is dependent on mycorrhizal fungi, which are crucial for its growth and adaptability in different environments. Hence, this study explores the ectomycorrhizal diversity of S. caprea by utilizing the taxonomy (morphotyping and a molecular approach using the ITS and LSU regions) and trait diversity (exploration types) at two test sites in Germany and Poland. In total, 19 ectomycorrhizal (EM) morphotypes of S. caprea were characterized. Seven taxa were identified at the species level (Hebeloma populinum, Cortinarius atrocoerulaeus, Inocybe hirtella, Laccaria cf. ochropurpurea, Tuber maculatum, Cenococcum geophilum, and Phialophora finlandia) and twelve at the genus level (Tomentella spp. 1–8, Hebeloma sp. 1, Inocybe sp. 1, and Tuber spp. 1–2). The EM colonization ranged from 14 to 28% of the fine root tips. At both test sites, the largest portion of the total EM colonization consisted of Thelephoraceae. The exploration types were classified as medium-distance smooth (Tomentella sp. 1–8 and L. ochropurpurea) and medium-distance fringe (C. atrocoerulaeus), while the other taxa were short-distance exploration types, highlighting their potential functional role in the adaptation and growth of S. caprea. Full article

Despite a rhetorical turn towards prevention in homelessness policy and research, the work of youth homelessness prevention continues to be frustrated by persistent structural barriers. In this article, we examine how youth homelessness prevention is being implemented in the province of Ontario, with a focus on targeted provincial support programs and local shelter diversion practices. Drawing on interviews with workers in the homeless-serving sector, we describe the implementation of these initiatives and identify points of frustration and potential that workers encounter as they try to prevent experiences of homelessness for youth. We contend that these points of frustration illuminate persistent structural barriers that continue to forestall the work of youth homelessness prevention. Meanwhile, points of potential demonstrate the importance of empowering workers to creatively adapt and offer responsive services. Taken together, these signal the critical importance of two aspects of contemporary homelessness prevention typologies—primordial prevention and empowerment. We end by offering aspirations for action, a political reframing of the policy recommendations sections more typical of social science research articles. We do so to affirm our commitment to advancing the work of structural transformation that is required to achieve the right to housing for all, including youth. Full article

Marine hermit crabs inhabiting different species of shells in the rocky intertidal may receive varied benefits and costs. Thick shell walls, sculpture, and certain silhouettes may increase protection against crushing predators and waves, but also the energy cost for bearing such a shell. To determine the relative energy demands on Pagurus granosimanus supporting one of three different species of shells commonly inhabited in nature, we measured the consumption of food by free-roaming, size-matched individuals after four days of food deprivation in the laboratory. Surprisingly, while all hermit crabs consumed a significant amount of food, that amount did not differ significantly across the types of shells inhabited, despite the significantly heavier weight of one type of shell (>150% of each of the other two species), and markedly different shell silhouettes. Whether our results were due to the inherent abilities of arthropods to support proportionally immense weights (physiology), reduced movements by animals in heavier shells (plastic behavior), or the way the hermit crabs bear the burden of the shell requires further investigation. Regardless, our results suggest that individuals of P. granosimanus that inhabit heavier shells that likely provide increased protection do not experience corresponding elevated food consumption requirements over the short term, even if those shells are not centered over the body mass of the hermit crab. Pagurus granosimanus crabs can bear the burden. Full article

This study explores a nanoemulsion formulated with açaí seed oil, known for its rich fatty acid composition and diverse biological activities. This study aimed to characterise a nanoemulsion formulated with açaí seed oil and explore its cytotoxic effects on HeLa and SiHa cervical cancer cell lines, alongside assessing its antioxidant and toxicity properties both in vitro and in vivo. Extracted from fruits sourced in Brazil, the oil underwent thorough chemical characterization using gas chromatography–mass spectrometry. The resulting nanoemulsion was prepared and evaluated for stability, particle size, and antioxidant properties. The nanoemulsion exhibited translucency, fluidity, and stability post centrifugation and temperature tests, with a droplet size of 238.37, PDI -9.59, pH 7, and turbidity 0.267. In vitro assessments on cervical cancer cell lines revealed antitumour effects, including inhibition of cell proliferation, migration, and colony formation. Toxicity tests conducted in cell cultures and female Swiss mice demonstrated no adverse effects of both açaí seed oil and nanoemulsion. Overall, açaí seed oil, particularly when formulated into a nanoemulsion, presents potential for cancer treatment due to its bioactive properties and safety profile. Full article

Rat animal models are widely used owing to their relatively superior cognitive abilities and higher similarity compared with mouse models to human physiological characteristics. However, their use is limited because of difficulties in establishing embryonic stem cells and performing genetic modifications, and insufficient embryological research. In this study, we established optimal superovulation and fertilized–egg transfer conditions, including optimal hormone injection concentration (≥150 IU/kg of PMSG and hCG) and culture medium (mR1ECM), to obtain high-quality zygotes and establish in vitro fertilization conditions for rats. Next, sgRNA with optimal targeting activity was selected by performing PCR analysis and the T7E1 assay, and the CRISPR/Cas9 system was used to construct a rat model for muscular dystrophy by inducing a deficiency in the fukutin gene without any off-target effect detected. The production of fukutin knockout rats was phenotypically confirmed by observing a drop-in body weight to one-third of that of the control group. In summary, we succeeded in constructing the first muscular dystrophy disease rat model using the CRISPR/CAS9 system for increasing future prospects of producing various animal disease models and encouraging disease research using rats. Full article

Many people experience intense fear of COVID-19. The purpose of this study was to provide a comprehensive visual overview of the published literature from 2020 to 2022 assessing fear of COVID-19. From 2020 to 2022, we employed the Scopus database to conduct a bibliometric analysis. We used the VOSviewer program to perform the author co-citation analysis, Mapchart to produce a worldwide map, and Wordart to make a word cloud image. From the 1769 records examined, 1654 (93.50%) were articles, with English being the most common language (96.31%). From 2020 to 2022, annual citations experienced significant growth (R² = 99.91%; p = 0.0195). The Institut National de la Santé et de la Recherche Médicale (INSERM, France) and China led in terms of publication output (n = 36; n = 255). M. D. Griffiths authored the highest number of articles (n = 21). The most active journal was the International Journal of Environmental Research and Public Health (n = 146), and the most prevalent keyword was “human/s” (11.51%). This bibliometric analysis evaluates the quality of the research on fear of the pandemic and the crisis management of COVID-19, which can provide managers and researchers with crucial insights for future decision making. Full article

Aim and Objectives: We aimed to test the predictive value of readily accessible and easily performed post-surgical “bedside tests” on their validity of long-term urinary incontinence (UI) (≥12 months) in patients following robot-assisted laparoscopic radical prostatectomy (RALP). Material and Methods: Patients undergoing RALP between July 2020 and March 2021 were prospectively included and subdivided into two groups based on their pad usage after 12 months (0 vs. ≥1 pad). After catheter removal, patients performed a 1 h pad test, documented the need for pad change in a micturition protocol and received post-voiding residual urine volume ultrasound. Univariate and multivariable analyses were used to demonstrate the predictive value of easily accessible tests applied after catheter removal for UI following RALP. Results: Of 109 patients, 47 (43%) had to use at least one pad (vs. 62 (57%) zero pads) after 12 months. Univariate testing showed a significant difference in urine loss between both groups evaluated by the 1 h pad test performed within 24 h after catheter removal (70% < 10 mL, vs. 30% ≥ 10 mL, p = 0.004) and in the need for pad change within the first 24 h after catheter removal (14% dry pads vs. 86% wet pads, p = 0.003). In multivariable analyses, the combination of both tests (synoptical incontinence score) could be confirmed as an independent predictor for UI after 12 months (p = 0.011). Conclusions: Readily accessible “everyday” diagnostics (pad test/change of pads after catheter removal) following RALP seem to be associated with a higher rate of long-term UI. This finding is crucial since patients with a potentially higher need for patient education and counselling can be identified using these readily accessible tests. This could lead to a higher patient satisfaction and improved outcomes. Full article

Background: Breast cancer (BC) is frequently diagnosed among Canadian women. While targeted therapies are available for most BC patients; treatment resistance is common and novel therapeutic targets are of interest. Thyroid hormones (TH) bound to thyroid hormone receptors (THR) influence cell proliferation and differentiation; they are also involved in the growth and development of normal breast tissue. Evidence suggests that THRβ is a tumor suppressor in various solid tumors. Purpose: This narrative review discusses retrospective studies regarding the clinical relevance of THRβ as a potential prognostic biomarker and therapeutic target in BC. Methods: We consulted with an information specialist to develop a search strategy to find all literature related to THRα expression as a potential prognostic and therapeutic biomarker in breast cancer. The primary search was developed for Medline and translated to Embase. The searches were conducted on the Ovid platform on 18 August 2023. Results: Across seven retrospective studies identified, several have shown an association between higher THRβ1 expression with a lower risk of BC recurrence and with longer overall survival. Conclusions: Some evidence suggests that THRβ expression is associated with a lower risk of BC recurrence and death. Validation of THRβ as an independent prognostic biomarker and possible predictive biomarker of response to endocrine therapy and/or chemotherapy is of interest. Given that THRβ is upstream of the AKT/PI3K pathway, its potential as a predictive biomarker of response to AKT inhibitors and/or PI3K inhibitors may also be of value. Finally, the potential re-purposing of THRβ agonists as anti-cancer agents warrants investigation. Full article

Myelodysplastic neoplasm (MDS) is a heterogeneous group of clonal hematological disorders that originate from the hematopoietic and progenitor cells and present with cytopenias and morphologic dysplasia with a propensity to progress to bone marrow failure or acute myeloid leukemia (AML). Genetic evolution plays a critical role in the pathogenesis, progression, and clinical outcomes of MDS. This process involves the acquisition of genetic mutations in stem cells that confer a selective growth advantage, leading to clonal expansion and the eventual development of MDS. With the advent of next-generation sequencing (NGS) assays, an increasing number of molecular aberrations have been discovered in recent years. The knowledge of molecular events in MDS has led to an improved understanding of the disease process, including the evolution of the disease and prognosis, and has paved the way for targeted therapy. The 2022 World Health Organization (WHO) Classification and the International Consensus Classification (ICC) have incorporated the molecular signature into the classification system for MDS. In addition, specific germline mutations are associated with MDS development, especially in pediatrics and young adults. This article reviews the genetic abnormalities of MDS in adults with a brief review of germline predisposition syndromes. Full article

This study investigated the effect of compaction effort and soaking time on the shear strength properties of fine-grained gypsum-containing soils. The objective was to demonstrate that increasing compaction effort increases soil strength, specifically cohesion and the angle of shear strength, when subjected to soaking in freshwater. Unconsolidated undrained triaxial tests were carried out on CBR soil samples with different soaking times. The results showed a transition from brittle to ductile failure behaviour as the soaking time increased. Mohr–Coulomb failure envelopes showed reduced cohesion and angle of shear strength with increasing soak time. Regression models were developed to establish correlations between soaked and unsoaked strength parameters. Strong relationships were found between soil strength properties, compaction effort and soaking time. Empirical equations were proposed to estimate the cohesion and angle of shear strength from compaction effort and soaking time. This study highlighted the importance of considering gypsum-rich soils in civil engineering design. Gypsum dissolution during wetting significantly affected soil strength parameters. The regression models and empirical equations provide engineers with tools to assess the influence of compaction effort and soaking time on soil strength, thus aiding decision making when designing structures on gypsum-rich soils. Full article

(1) Current literature on ethnic minorities, comorbidities, and COVID-19 tends to investigate these factors separately, leaving gaps in our understanding about their interactions. Our review seeks to identify a relationship between ethnicity, comorbidities, and severe COVID-19 outcomes (ICU admission and mortality). We hope to enhance our understanding of the various factors that exacerbate COVID-19 severity and mortality in ethnic minorities in Canada and the USA. (2) All articles were received from PubMed, Scopus, CINAHL, and Ovid EMBASE from November 2020 to June 2022. Included articles contain information regarding comorbidities among ethnic minorities in relation to COVID-19 severity and mortality. (3) A total of 59 articles were included that examined various ethnic groups, including Black/African American, Asian, Hispanic, White/Caucasian, and Indigenous people. We found that the most examined comorbidities were diabetes, hypertension, obesity, and chronic kidney disease. A total of 76.9% of the articles (40 out of 52) found a significant association between different races and COVID-19 mortality, whereas 21.2% of the articles (11 out of 52) did not. (4) COVID-19 ICU admissions and mortality affect various ethnic groups differently, with Black patients generally having the most adverse outcomes. These outcomes may also interact with sex and age, though more research is needed assessing these variables together with ethnicity. Full article