The 2023 MDPI Annual Report has
been released!
 
13 pages, 1061 KiB  
Article
The Changing Detection Rate of Respiratory Syncytial Virus in Adults in Western Australia between 2017 and 2023
by David A. Foley, Cara A. Minney-Smith, Andrew Tjea, Mark P. Nicol, Avram Levy, Hannah C. Moore and Christopher C. Blyth
Viruses 2024, 16(5), 656; https://doi.org/10.3390/v16050656 (registering DOI) - 23 Apr 2024
Abstract
The incidence of respiratory syncytial virus (RSV) in adults is inadequately defined and the impact of SARS-CoV-2-related non-pharmaceutical interventions (NPIs) is underexplored. Using laboratory data, we described the detection rate of RSV in adults ≥16 years in Western Australia (WA) between 2017 and [...] Read more.
The incidence of respiratory syncytial virus (RSV) in adults is inadequately defined and the impact of SARS-CoV-2-related non-pharmaceutical interventions (NPIs) is underexplored. Using laboratory data, we described the detection rate of RSV in adults ≥16 years in Western Australia (WA) between 2017 and 2023. With the exception of 2020, RSV detections rose annually between 2017 and 2023, reaching 50.7 per 100,000 in 2023 (95% confidence interval [CI], 47.9–53.8). RSV testing expanded considerably across the study period, with the testing in 2023 more than five times the 2017 total. The detection rate was highest in adults ≥60 years between 2017 and 2019, particularly those ≥75 years. Following 2020, the detections in all age groups increased, with the highest detection rate in 2023 in those ≥75-years (199.5 per 100,000; 95% CI, 180.5–220). NPIs significantly impacted RSV seasonality; the preceding winter pattern was disrupted, resulting in an absent 2020 winter season and two major summer seasons in 2020/21 and 2021/22. The RSV season began to realign in 2022, reverting to a winter seasonal pattern in 2023 and the largest season in the study period. Ongoing surveillance will be required to understand the stability of these increases and to delineate the impact of new immunisation strategies. Full article
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12 pages, 7880 KiB  
Article
A Proposal for Sediment Control Countermeasures in Non-Flowing Mountain Streams
by Norio Harada, Yoshifumi Satofuka and Takahisa Mizuyama
Water 2024, 16(9), 1197; https://doi.org/10.3390/w16091197 (registering DOI) - 23 Apr 2024
Abstract
In Japan, the heavy rain disaster that occurred in July 2018 revealed that about 70% of the streams affected by debris flows that resulted in human casualties were small, steep mountain streams with a catchment area < 0.05 km2. Generally, many [...] Read more.
In Japan, the heavy rain disaster that occurred in July 2018 revealed that about 70% of the streams affected by debris flows that resulted in human casualties were small, steep mountain streams with a catchment area < 0.05 km2. Generally, many streams that are close to residential houses or roads do not have a constant flow of water and are known to pose a high risk of human fatalities when a debris flow occurs. This study aimed to promote sediment control as debris flow countermeasures in non-flowing mountain streams, utilizing secondary manufactured products (permeable debris flow barriers) with excellent constructability, focusing on the mechanism of sediment outflow from the gaps between a permeable debris flow barrier and mountain stream side banks. The necessity and effectiveness of preventative measures based on preliminary experimental results are presented. When impermeable structures were installed at both ends of the permeable debris flow barrier side, compared to using only a permeable debris flow barrier (covering the entire width with permeable debris flow barriers), we found that the capture function improved significantly, achieving a 200% increase in effectiveness. Full article
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19 pages, 1076 KiB  
Review
Axillary Surgery for Breast Cancer in 2024
by Martin Heidinger and Walter P. Weber
Cancers 2024, 16(9), 1623; https://doi.org/10.3390/cancers16091623 (registering DOI) - 23 Apr 2024
Abstract
Axillary surgery for patients with breast cancer (BC) in 2024 is becoming increasingly specific, moving away from the previous ‘one size fits all’ radical approach. The goal is to spare morbidity whilst maintaining oncologic safety. In the upfront surgery setting, a first landmark [...] Read more.
Axillary surgery for patients with breast cancer (BC) in 2024 is becoming increasingly specific, moving away from the previous ‘one size fits all’ radical approach. The goal is to spare morbidity whilst maintaining oncologic safety. In the upfront surgery setting, a first landmark randomized controlled trial (RCT) on the omission of any surgical axillary staging in patients with unremarkable clinical examination and axillary ultrasound showed non-inferiority to sentinel lymph node (SLN) biopsy (SLNB). The study population consisted of 87.8% postmenopausal patients with estrogen receptor-positive, human epidermal growth factor receptor 2-negative BC. Patients with clinically node-negative breast cancer and up to two positive SLNs can safely be spared axillary dissection (ALND) even in the context of mastectomy or extranodal extension. In patients enrolled in the TAXIS trial, adjuvant systemic treatment was shown to be similar with or without ALND despite the loss of staging information. After neoadjuvant chemotherapy (NACT), targeted lymph node removal with or without SLNB showed a lower false-negative rate to determine nodal pathological complete response (pCR) compared to SLNB alone. However, oncologic outcomes do not appear to differ in patients with nodal pCR determined by either one of the two concepts, according to a recently published global, retrospective, real-world study. Real-world studies generally have a lower level of evidence than RCTs, but they are feasible quickly and with a large sample size. Another global real-world study provides evidence that even patients with residual isolated tumor cells can be safely spared from ALND. In general, few indications for ALND remain. Three randomized controlled trials are ongoing for patients with clinically node-positive BC in the upfront surgery setting and residual disease after NACT. Pending the results of these trials, ALND remains indicated in these patients. Full article
(This article belongs to the Special Issue Clinical Research and Progress in the Treatment of Breast Cancer)
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21 pages, 4111 KiB  
Article
Activin A, a Novel Chemokine, Induces Mouse NK Cell Migration via AKT and Calcium Signaling
by Yunfeng Wang, Zhonghui Liu, Yan Qi, Jiandong Wu, Boyang Liu and Xueling Cui
Cells 2024, 13(9), 728; https://doi.org/10.3390/cells13090728 (registering DOI) - 23 Apr 2024
Abstract
Natural killer (NK) cells can migrate quickly to the tumor site to exert cytotoxic effects on tumors, and some chemokines, including CXCL8, CXCL10 or and CXCL12, can regulate the migration of NK cells. Activin A, a member of the transforming growth factor β [...] Read more.
Natural killer (NK) cells can migrate quickly to the tumor site to exert cytotoxic effects on tumors, and some chemokines, including CXCL8, CXCL10 or and CXCL12, can regulate the migration of NK cells. Activin A, a member of the transforming growth factor β (TGF-β) superfamily, is highly expressed in tumor tissues and involved in tumor development and immune cell activation. In this study, we focus on the effects of activin A on NK cell migration. In vitro, activin A induced NK cell migration and invasion, promoted cell polarization and inhibited cell adhesion. Moreover, activin A increased Ca2+, p-SMAD3 and p-AKT levels in NK cells. An AKT inhibitor and Ca2+ chelator partially blocked activin A-induced NK cell migration. In vivo, exogenous activin A increased tumor-infiltrating NK cells in NS-1 cell solid tumors and inhibited tumor growth, and blocking endogenous activin A with anti-activin A antibody reduced tumor-infiltrating NK cells in 4T-1 cell solid tumors. These results suggest that activin A induces NK cell migration through AKT signaling and calcium signaling and may enhance the antitumor effect of NK cells by increasing tumor-infiltrating NK cells. Full article
(This article belongs to the Section Cellular Immunology)
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18 pages, 4868 KiB  
Article
Unraveling the Interactions between Lithium and Twisted Graphene
by Maximo Ramírez, Giorgio De Luca and Lorenzo Caputi
Materials 2024, 17(9), 1941; https://doi.org/10.3390/ma17091941 (registering DOI) - 23 Apr 2024
Abstract
Graphene is undoubtedly the carbon allotrope that has attracted the attention of a myriad of researchers in the last decades more than any other. The interaction of external or intercalated Li and Li+ with graphene layers has been the subject of particular [...] Read more.
Graphene is undoubtedly the carbon allotrope that has attracted the attention of a myriad of researchers in the last decades more than any other. The interaction of external or intercalated Li and Li+ with graphene layers has been the subject of particular attention for its importance in the applications of graphene layers in Lithium Batteries (LiBs). It is well known that lithium atoms and Li+ can be found inside and/or outside the double layer of graphene, and the graphene layers are often twisted around its parallel plane to obtain twisted graphene with tuneable properties. Thus, in this research, the interactions between Li and Li+ with bilayer graphene and twisted bilayer graphene were investigated by a first-principles density functional theory method, considering the lithium atom and the cation at different symmetry positions and with two different adsorption configurations. Binding energies and equilibrium interlayer distances of filled graphene layers were obtained from the computed potential energy profiles. This work shows that the twisting can regulate the interaction of bilayer graphene with Li and Li+. The binding energies of Li+ systematically increase from bilayer graphene to twisted graphene regardless of twisted angles, while for lithium atoms, the binding energies decrease or remain substantially unchanged depending on the twist angles. This suggests a higher adsorption capacity of twisted graphene towards Li+, which is important for designing twisted graphene-based material for LiB anode coating. Furthermore, when the Li or Li+ is intercalated between two graphene layers, the equilibrium interlayer distances in the twisted layers increase compared to the unrotated bilayer, and the relaxation is more significant for Li+ with respect to Li. This suggests that the twisted graphene can better accommodate the cation in agreement with the above result. The outcomes of this research pave the way for the study of the selective properties of twisted graphene. Full article
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14 pages, 1947 KiB  
Review
Nature-Inspired Micro/Nano-Structured Antibacterial Surfaces
by E Jin, Zhijun Lv, Yinghao Zhu, Hongmei Zhang and He Li
Molecules 2024, 29(9), 1906; https://doi.org/10.3390/molecules29091906 (registering DOI) - 23 Apr 2024
Abstract
The problem of bacterial resistance has become more and more common with improvements in health care. Worryingly, the misuse of antibiotics leads to an increase in bacterial multidrug resistance and the development of new antibiotics has virtually stalled. These challenges have prompted the [...] Read more.
The problem of bacterial resistance has become more and more common with improvements in health care. Worryingly, the misuse of antibiotics leads to an increase in bacterial multidrug resistance and the development of new antibiotics has virtually stalled. These challenges have prompted the need to combat bacterial infections with the use of radically different approaches. Taking lessons from the exciting properties of micro-/nano-natural-patterned surfaces, which can destroy cellular integrity, the construction of artificial surfaces to mimic natural functions provides new opportunities for the innovation and development of biomedicine. Due to the diversity of natural surfaces, functional surfaces inspired by natural surfaces have a wide range of applications in healthcare. Nature-inspired surface structures have emerged as an effective and durable strategy to prevent bacterial infection, opening a new way to alleviate the problem of bacterial drug resistance. The present situation of bactericidal and antifouling surfaces with natural and biomimetic micro-/nano-structures is briefly reviewed. In addition, these innovative nature-inspired methods are used to manufacture a variety of artificial surfaces to achieve extraordinary antibacterial properties. In particular, the physical antibacterial effect of nature-inspired surfaces and the functional mechanisms of chemical groups, small molecules, and ions are discussed, as well as the wide current and future applications of artificial biomimetic micro-/nano-surfaces. Current challenges and future development directions are also discussed at the end. In the future, controlling the use of micro-/nano-structures and their subsequent functions will lead to biomimetic surfaces offering great potential applications in biomedicine. Full article
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14 pages, 360 KiB  
Article
Metalinguistic Commentary on Forms of Address in a Finnish Autobiographical Novel Series
by Hanna Lappalainen and Maija Saviniemi
Languages 2024, 9(5), 153; https://doi.org/10.3390/languages9050153 (registering DOI) - 23 Apr 2024
Abstract
This article examines the metalinguistic commentary on address practices in a Finnish autobiographical novel series, the 26-volume Iijoki-sarja ‘Iijoki Series’ (1971–1998) by Kalle Päätalo. Our aim is to show how the forms of address affect the protagonist and other characters. The study is [...] Read more.
This article examines the metalinguistic commentary on address practices in a Finnish autobiographical novel series, the 26-volume Iijoki-sarja ‘Iijoki Series’ (1971–1998) by Kalle Päätalo. Our aim is to show how the forms of address affect the protagonist and other characters. The study is anchored in previous sociopragmatic research on address and in folk linguistics. The analysis is based on searches in the digital corpus of the whole series by means of keywords related to forms of address. The analysis proceeds chronologically, from Kalle’s childhood and adolescence to his marriage and working life, including his social rise from a poor country boy to a full-time novel writer. Our results show that Kalle, the fictional protagonist of the series, mirrors his own and others’ choices in address practices throughout his life against the norms he has learned in his childhood. These choices are explained by the (relative) age, sex, status and regional background of the interlocutors. Metalinguistic comments reflect the characters’ social relations and changes in them during the protagonist’s linguistic biography. We argue that fiction can open up perceptions and contexts related to address practices that are not easily accessible by other methods or datasets. Full article
(This article belongs to the Special Issue Perception and Processing of Address Terms)
28 pages, 6294 KiB  
Article
A Comparative Study of the Antiemetic Effects of α2-Adrenergic Receptor Agonists Clonidine and Dexmedetomidine against Diverse Emetogens in the Least Shrew (Cryptotis parva) Model of Emesis
by Yina Sun and Nissar A. Darmani
Int. J. Mol. Sci. 2024, 25(9), 4603; https://doi.org/10.3390/ijms25094603 (registering DOI) - 23 Apr 2024
Abstract
In contrast to cats and dogs, here we report that the α2-adrenergic receptor antagonist yohimbine is emetic and corresponding agonists clonidine and dexmedetomidine behave as antiemetics in the least shrew model of vomiting. Yohimbine (0, 0.5, 0.75, 1, 1.5, 2, and [...] Read more.
In contrast to cats and dogs, here we report that the α2-adrenergic receptor antagonist yohimbine is emetic and corresponding agonists clonidine and dexmedetomidine behave as antiemetics in the least shrew model of vomiting. Yohimbine (0, 0.5, 0.75, 1, 1.5, 2, and 3 mg/kg, i.p.) caused vomiting in shrews in a bell-shaped and dose-dependent manner, with a maximum frequency (0.85 ± 0.22) at 1 mg/kg, which was accompanied by a key central contribution as indicated by increased expression of c-fos, serotonin and substance P release in the shrew brainstem emetic nuclei. Our comparative study in shrews demonstrates that clonidine (0, 0.1, 1, 5, and 10 mg/kg, i.p.) and dexmedetomidine (0, 0.01, 0.05, and 0.1 mg/kg, i.p.) not only suppress yohimbine (1 mg/kg, i.p.)-evoked vomiting in a dose-dependent manner, but also display broad-spectrum antiemetic effects against diverse well-known emetogens, including 2-Methyl-5-HT, GR73632, McN-A-343, quinpirole, FPL64176, SR141716A, thapsigargin, rolipram, and ZD7288. The antiemetic inhibitory ID50 values of dexmedetomidine against the evoked emetogens are much lower than those of clonidine. At its antiemetic doses, clonidine decreased shrews’ locomotor activity parameters (distance moved and rearing), whereas dexmedetomidine did not do so. The results suggest that dexmedetomidine represents a better candidate for antiemetic potential with advantages over clonidine. Full article
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17 pages, 7003 KiB  
Article
Stability and Failure of Thin-Walled Composite Plate Elements with Asymmetric Configurations
by Katarzyna Falkowicz
Materials 2024, 17(9), 1943; https://doi.org/10.3390/ma17091943 (registering DOI) - 23 Apr 2024
Abstract
In the present study, the stability and failure phenomena of thin-walled constructions subjected to axial compression, featuring a central cut-out, and constructed from composite materials were explored. These constructions were fabricated from a carbon–epoxy composite using the autoclave method. The research encompassed experimental [...] Read more.
In the present study, the stability and failure phenomena of thin-walled constructions subjected to axial compression, featuring a central cut-out, and constructed from composite materials were explored. These constructions were fabricated from a carbon–epoxy composite using the autoclave method. The research encompassed experimental assessments on actual specimens alongside numerical analyses employing the finite element approach within the ABAQUS® software. The investigation spanned the entire load spectrum up to the point of structural failure, incorporating both practical trials and simulation analysis. During the practical assessments, the study monitored the post-buckling response and captured acoustic emissions to thoroughly evaluate the composite’s failure mechanisms. Additionally, the ARAMIS system’s non-invasive three-dimensional scanning was employed to assess deformations. Theoretical simulations utilized a step-by-step failure analysis, initiating with failure onset as per Hashin’s theory and proceeding to failure progression based on an energy criterion. The simulation outcomes, particularly concerning the critical and post-critical phases, were juxtaposed with empirical data to identify the composite’s vulnerability zones. The comparison underscored a significant concordance between the simulation predictions and the empirical findings. Full article
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10 pages, 208 KiB  
Article
Intellectual Humility and the Argument from Evil: A Reply to Zain Ali
by John Bishop and Ken Perszyk
Religions 2024, 15(5), 522; https://doi.org/10.3390/rel15050522 (registering DOI) - 23 Apr 2024
Abstract
This is a response to Zain Ali’s critique in this journal of our presentation of a ‘right relationship’ normatively relativised ‘logical’ Argument from Evil. Our argument aims to show that the existence of horrendous evils (as defined by Marilyn Adams) is incompatible with [...] Read more.
This is a response to Zain Ali’s critique in this journal of our presentation of a ‘right relationship’ normatively relativised ‘logical’ Argument from Evil. Our argument aims to show that the existence of horrendous evils (as defined by Marilyn Adams) is incompatible with the existence of the personal omniGod (a person or personal being who is all-powerful, all-knowing, and perfectly good), given certain reasonable judgments about what a personal God’s perfect goodness would imply about the way God relates to those caught up in horrendous evils. We reply to Ali’s main criticism that our assumptions about divine goodness are unjustified, and show a lack of intellectual humility. We defend the claim that, if God is a person, then God’s goodness is moral goodness according to our best human theory of what that implies. We accept that God’s situation as creator and sustainer of all that exists may justify ‘divine exceptionalism’: God’s personal moral goodness may be consistent with ways of relating to others that would fall far short of perfection in human-to-human relationships. But in that case, we argue, intellectual humility may be better served by accepting that God is so exceptional that God should not be understood as a person at all, which is the prevailing Muslim view, as Ali himself acknowledges. Full article
(This article belongs to the Special Issue Problems in Contemporary Islamic Philosophy of Religion)
34 pages, 9496 KiB  
Article
Telemetry System to Monitor Elastic Torque on Rolling Stand Spindles
by Stanislav S. Voronin, Boris M. Loginov, Olga A. Gasiyarova, Sergey A. Evdokimov, Alexander S. Karandaev and Vadim R. Khramshin
J. Manuf. Mater. Process. 2024, 8(3), 85; https://doi.org/10.3390/jmmp8030085 (registering DOI) - 23 Apr 2024
Abstract
This article outlines the relevance of building online telemetry systems for online monitoring of the technical conditions of rolling mill equipment. Electromechanical systems of the horizontal stand of the plate Mill 5000 are described, when operating in harsh conditions caused by the shock [...] Read more.
This article outlines the relevance of building online telemetry systems for online monitoring of the technical conditions of rolling mill equipment. Electromechanical systems of the horizontal stand of the plate Mill 5000 are described, when operating in harsh conditions caused by the shock loading when workpieces enter the stand. It is noted that dynamic torque overloads, exceeding the rated motor torque by many-fold, cause the fatigue failure of spindle joints and breakage of rolls. In this regard, the development and implementation of systems for monitoring the elastic torque on spindles are extremely urgent. This issue has long been studied, but the references provide no information on the building principles and hardware composition of such systems. The use of strain gauges connected according to a balanced bridge circuit to measure the elastic torque is justified. This paper’s contribution is the proposed modular principle for building a telemetry monitoring system based on the analysis of known techniques for measuring and transmitting diagnostic data. The developed system structure is provided and the concept of data transfer and processing are explained. This article suggests the inductive power supply of a measuring unit mounted on a shaft without the use of batteries. A hardware structure was developed to be applied in a system for measuring, transmitting, and visualizing signals proportional to the elastic torque, manufactured on the basis of data measuring instruments by leading companies. The specifics of placement and connection of strain gauges are considered. The hardware providing a wireless power supply to the signal encoder and digital data transfer between the transmitter and receiver is described. The results of implementing the system on Mill 5000 are provided. The installation of a telemetry ring and a receiving head for the inductive power supply and data reception is shown. An experimental assessment of the elastic torques occurring when workpieces enter the cage was obtained by implementing a drive control algorithm which provided biting in the drive acceleration mode. The reliability of measuring the elastic torque with an error not exceeding ±5% and the reduction of dynamic loads on the spindle by 1.3–1.5 times due to the elimination of impacts from closing angular gaps in spindle joints was confirmed. This increases the service life of mechanical equipment and reduces the cost of eliminating the accident aftermath. The prospect of modifying the developed system into a cyber-physical system for monitoring the rolling mill’s mechatronic equipment conditions is shown. Full article
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21 pages, 10505 KiB  
Article
Cellular Response of Adapted and Non-Adapted Tetrahymena thermophila Strains to Europium Eu(III) Compounds
by Patricia Alonso, Javier Blas, Francisco Amaro, Patricia de Francisco, Ana Martín-González and Juan Carlos Gutiérrez
Biology 2024, 13(5), 285; https://doi.org/10.3390/biology13050285 (registering DOI) - 23 Apr 2024
Abstract
Europium is one of the most reactive lanthanides and humans use it in many different applications, but we still know little about its potential toxicity and cellular response to its exposure. Two strains of the eukaryotic microorganism model Tetrahymena thermophila were adapted to [...] Read more.
Europium is one of the most reactive lanthanides and humans use it in many different applications, but we still know little about its potential toxicity and cellular response to its exposure. Two strains of the eukaryotic microorganism model Tetrahymena thermophila were adapted to high concentrations of two Eu(III) compounds (EuCl3 or Eu2O3) and compared to a control strain and cultures treated with both compounds. In this ciliate, EuCl3 is more toxic than Eu2O3. LC50 values show that this microorganism is more resistant to these Eu(III) compounds than other microorganisms. Oxidative stress originated mainly by Eu2O3 is minimized by overexpression of genes encoding important antioxidant enzymes. The overexpression of metallothionein genes under treatment with Eu(III) compounds supports the possibility that this lanthanide may interact with the -SH groups of the cysteine residues from metallothioneins and/or displace essential cations of these proteins during their homeostatic function. Both lipid metabolism (lipid droplets fusing with europium-containing vacuoles) and autophagy are involved in the cellular response to europium stress. Bioaccumulation, together with a possible biomineralization to europium phosphate, seems to be the main mechanism of Eu(III) detoxification in these cells. Full article
(This article belongs to the Collection Feature Papers in Microbial Biology)
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11 pages, 528 KiB  
Article
Self-Control, Openness, Personal Need for Structure and Compensatory Control Change: A Serial Mediation Investigation
by Yuan Zhao, Yuying Wang, Liuqing Wei, Yu Ma, Yunyun Chen and Xuemin Zhang
Behav. Sci. 2024, 14(5), 352; https://doi.org/10.3390/bs14050352 (registering DOI) - 23 Apr 2024
Abstract
In the aftermath of the COVID-19 pandemic, numerous studies have indicated that individuals are confronting a diminished sense of control. Compensatory control theory suggests that individuals strive to mitigate this loss by modifying their behavior. The present study aims to investigate the relationship [...] Read more.
In the aftermath of the COVID-19 pandemic, numerous studies have indicated that individuals are confronting a diminished sense of control. Compensatory control theory suggests that individuals strive to mitigate this loss by modifying their behavior. The present study aims to investigate the relationship between self-control and compensatory control change during the COVID-19 pandemic, as well as the mediating effects of openness and the personal need for structure. Participants completed an online questionnaire consisting of Personal Need for Structure Scale, Self-Control Scale, Openness Scale and Compensatory Control Change Scale. The results showed that the compensatory control change increased after the outbreak. Moreover, a serial mediation was found: openness and the personal need for structure partially mediated the relationship between self-control and compensatory control change. The results indicate that the COVID-19 pandemic has led to an increase in compensatory control behaviors, especially among those with pronounced self-control. High self-control individuals are found to exhibit greater openness, reducing their personal need for structure, in effect enhancing their compensatory control change. These findings highlight the critical role of self-control in sustaining a sense of control, which is vital for understanding psychological health management in the context of public health events. Full article
(This article belongs to the Section Social Psychology)
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20 pages, 3610 KiB  
Article
Research on Complex Network Models and Characteristics of Building Material Enterprises Based on Competitive Relationships
by Likun Zhao, Hui Yuan, Mengqian An and Xiaoqing Bao
Buildings 2024, 14(5), 1192; https://doi.org/10.3390/buildings14051192 (registering DOI) - 23 Apr 2024
Abstract
Based on complex network theory, this paper establishes a Boolean competitive relationship network model and a weighted competitive relationship network model for building material enterprises based on big data and performs empirical analyses with construction prefabricated component (PC) enterprises in the Beijing–Tianjin–Hebei region [...] Read more.
Based on complex network theory, this paper establishes a Boolean competitive relationship network model and a weighted competitive relationship network model for building material enterprises based on big data and performs empirical analyses with construction prefabricated component (PC) enterprises in the Beijing–Tianjin–Hebei region as research samples. Results show the competitive relationship network of PC enterprises in the Beijing–Tianjin–Hebei region is characterised by the development of a small-world network, and its cumulative degree and out-degree (in-degree) intensity distributions are single-scale networks with fast-decaying tails. The network has strong network clustering and assortativity, and it can truly reflect the competitive status and dynamics of the enterprises. Full article
(This article belongs to the Section Construction Management, and Computers & Digitization)
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26 pages, 3002 KiB  
Article
Terroir Dynamics: Impact of Vineyard and Canopy Treatment with Chitosan on Anthocyanins, Phenolics, and Volatile and Sensory Profiles of Pinot Noir Wines from South Tyrol
by Prudence Fleur Tchouakeu Betnga, Simone Poggesi, Aakriti Darnal, Edoardo Longo, Elena Rudari and Emanuele Boselli
Molecules 2024, 29(9), 1916; https://doi.org/10.3390/molecules29091916 (registering DOI) - 23 Apr 2024
Abstract
The effects of canopy treatment with chitosan and the effects of the vineyard location on the quality parameters, volatile and non-volatile profiles, and sensory profile of Pinot Noir wines from South Tyrol (Italy) were studied. Multivariate statistical analysis was applied to identify the [...] Read more.
The effects of canopy treatment with chitosan and the effects of the vineyard location on the quality parameters, volatile and non-volatile profiles, and sensory profile of Pinot Noir wines from South Tyrol (Italy) were studied. Multivariate statistical analysis was applied to identify the most relevant compounds associated with the variability in phenolics and anthocyanins (analyzed by UHPLC-MS), volatile components (HS-SPME-GCxGC-ToF/MS), and basic enological parameters. A clear separation of low-altitude wines (350 m.a.s.l.), which had a high concentration of most of the identified volatile compounds, compared to high-altitude wines (800 and 1050–1150 m.a.s.l.) was pointed out. Low altitude minimized the concentration of the most significant anthocyanins in wines from a valley bottom, presumably due to reduced sun exposure. Wines obtained from chitosan-treated canopies, and, more particularly, those subjected to multiple treatments per year showed a higher amount of the main non-volatile phenolics and were sensorially described as having “unpleasant flavors” and “odors”, which might suggest that grape metabolism is slightly altered compared to untreated grapevines. Thus, optimization of the treatment with chitosan should be further investigated. Full article
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19 pages, 917 KiB  
Review
Clearing the Fog: A Scoping Literature Review on the Ethical Issues Surrounding Artificial Intelligence-Based Medical Devices
by Alessia Maccaro, Katy Stokes, Laura Statham, Lucas He, Arthur Williams, Leandro Pecchia and Davide Piaggio
J. Pers. Med. 2024, 14(5), 443; https://doi.org/10.3390/jpm14050443 (registering DOI) - 23 Apr 2024
Abstract
The use of AI in healthcare has sparked much debate among philosophers, ethicists, regulators and policymakers who raised concerns about the implications of such technologies. The presented scoping review captures the progression of the ethical and legal debate and the proposed ethical frameworks [...] Read more.
The use of AI in healthcare has sparked much debate among philosophers, ethicists, regulators and policymakers who raised concerns about the implications of such technologies. The presented scoping review captures the progression of the ethical and legal debate and the proposed ethical frameworks available concerning the use of AI-based medical technologies, capturing key themes across a wide range of medical contexts. The ethical dimensions are synthesised in order to produce a coherent ethical framework for AI-based medical technologies, highlighting how transparency, accountability, confidentiality, autonomy, trust and fairness are the top six recurrent ethical issues. The literature also highlighted how it is essential to increase ethical awareness through interdisciplinary research, such that researchers, AI developers and regulators have the necessary education/competence or networks and tools to ensure proper consideration of ethical matters in the conception and design of new AI technologies and their norms. Interdisciplinarity throughout research, regulation and implementation will help ensure AI-based medical devices are ethical, clinically effective and safe. Achieving these goals will facilitate successful translation of AI into healthcare systems, which currently is lagging behind other sectors, to ensure timely achievement of health benefits to patients and the public. Full article
(This article belongs to the Special Issue Artificial Intelligence Applied to Clinical Practice)
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15 pages, 259 KiB  
Article
The Effects of the COVID-19 Pandemic on Healthcare Providers’ Mental Health: Experiences at Kenyatta National Hospital, Kenya
by Vallery Ogello, Nicholas Thuo, Phelix Okello, Njeri Wairimu, Paul Mwangi, Gakuo Maina, Harrison Mwenda, Paul Mutua, John Kinuthia, Linnet Ongeri, Nelly Mugo and Kenneth Ngure
Behav. Sci. 2024, 14(5), 351; https://doi.org/10.3390/bs14050351 (registering DOI) - 23 Apr 2024
Abstract
Background: In 2020, healthcare providers were expected to provide care to individuals with coronavirus disease 2019 (COVID-19), putting them at risk of acquiring COVID-19. The possibility of acquiring poorly understood infectious diseases while providing care may have an impact on the mental health [...] Read more.
Background: In 2020, healthcare providers were expected to provide care to individuals with coronavirus disease 2019 (COVID-19), putting them at risk of acquiring COVID-19. The possibility of acquiring poorly understood infectious diseases while providing care may have an impact on the mental health of providers. We conducted a study to explore the effects of COVID-19 on the mental health of healthcare providers. Methods: Between April and August 2021, we conducted in-depth interviews with 60 healthcare providers in the infectious disease unit (IDU) and other units of the hospital (non-IDU). The healthcare providers completed an online self-administered survey form with demographic data (age, sex, average income, and known contact with a COVID-19 patient). We used semi-structured interview guides to understand the healthcare providers’ lived experiences of stress, anxiety, depression, and their associated factors. We transcribed the interviews verbatim and coded and analyzed the transcripts to derive thematic concepts related to mental health experiences. Results: The healthcare providers had a median age of 37 years [IQR 20.0–58.0], and 56.7% were female, 30.0% nurses, 18.3% medical doctors, and 11.7% laboratory technologists. The healthcare providers reported increased stress during the pandemic, attributed to the high demand for patient care, changes in social life, and fear of COVID-19 infection. They also reported experiences of anxiety and depression as a result of limited knowledge at the beginning of the pandemic and the perception that “COVID-19 resulted in death”. Testing positive for COVID-19, high exposure to COVID-19 risks, and the death of patients and colleagues reportedly affected the healthcare providers’ mental health. Additionally, the healthcare providers reported mental health support through debriefing meetings, peer-to-peer support, and psychological counseling, with privacy and confidentiality concerns. Conclusions: Healthcare providers faced mental health issues such as stress and anxiety while taking care of COVID-19 patients. An effective mental health response requires institutional practices that address context-specific challenges such as privacy and confidentiality. Full article
(This article belongs to the Section Health Psychology)
16 pages, 595 KiB  
Systematic Review
Prognostic Significance of Lung Ultrasound for Heart Failure Patient Management in Primary Care: A Systematic Review
by Anna Panisello-Tafalla, Marcos Haro-Montoya, Rosa Caballol-Angelats, Maylin Montelongo-Sol, Yoenia Rodriguez-Carralero, Jorgina Lucas-Noll and Josep Lluis Clua-Espuny
J. Clin. Med. 2024, 13(9), 2460; https://doi.org/10.3390/jcm13092460 (registering DOI) - 23 Apr 2024
Abstract
Background: Heart failure (HF) affects around 60 million individuals worldwide. The primary aim of this study was to evaluate the efficacy of lung ultrasound (LUS) in managing HF with the goal of reducing hospital readmission rates. Methods: A systematic search was conducted on [...] Read more.
Background: Heart failure (HF) affects around 60 million individuals worldwide. The primary aim of this study was to evaluate the efficacy of lung ultrasound (LUS) in managing HF with the goal of reducing hospital readmission rates. Methods: A systematic search was conducted on PubMed, Embase, Google Scholar, Web of Science, and Scopus, covering clinical trials, meta-analyses, systematic reviews, and original articles published between 1 January 2019 and 31 December 2023, focusing on LUS for HF assessment in out-patient settings. There is a potential for bias as the effectiveness of interventions may vary depending on the individuals administering them. Results: The PRISMA method synthesized the findings. Out of 873 articles identified, 33 were selected: 19 articles focused on prognostic assessment of HF, 11 centred on multimodal diagnostic assessments, and two addressed therapeutic guidance for HF diagnosis. LUS demonstrates advantages in detecting subclinical congestion, which holds prognostic significance for readmission and mortality during out-patient follow-up post-hospital-discharge, especially in complex scenarios, but there is a lack of standardization. Conclusions: there are considerable uncertainties in their interpretation and monitoring changes. The need for an updated international consensus on the use of LUS seems obvious. Full article
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26 pages, 5473 KiB  
Article
Simulation of the Dynamic Responses of Layered Polymer Composites under Plate Impact Using the DSGZ Model
by Huadian Zhang, Arunachalam M. Rajendran, Manoj K. Shukla, Sasan Nouranian, Ahmed Al-Ostaz, Steven Larson and Shan Jiang
J. Compos. Sci. 2024, 8(5), 159; https://doi.org/10.3390/jcs8050159 (registering DOI) - 23 Apr 2024
Abstract
This paper presents a numerical study on the dynamic response and impact mitigation capabilities of layered ceramic–polymer–metal (CPM) composites under plate impact loading, focusing on the layer sequence effect. The layered structure, comprising a ceramic for hardness and thermal resistance, a polymer for [...] Read more.
This paper presents a numerical study on the dynamic response and impact mitigation capabilities of layered ceramic–polymer–metal (CPM) composites under plate impact loading, focusing on the layer sequence effect. The layered structure, comprising a ceramic for hardness and thermal resistance, a polymer for energy absorption, and a metal for strength and ductility, is analyzed to evaluate its effectiveness in mitigating the impact loading. The simulations employed the VUMAT subroutine of DSGZ material models within Abaqus/Explicit to accurately represent the mechanical behavior of the polymeric materials in the composites. The VUMAT implementation incorporates the explicit time integration scheme and the implicit radial return mapping algorithm. A safe-version Newton–Raphson method is applied for numerically solving the differential equations of the J2 plastic flow theory. Analysis of the simulation results reveals that specific layer configurations significantly influence wave propagation, leading to variations in energy absorption and stress distribution within the material. Notably, certain layer sequences, such as P-C-M and C-P-M, exhibit enhanced impact mitigation with a superior ability to dissipate and redirect the impact energy. This phenomenon is tied to the interactions between the material properties of the ceramic, polymer, and metal, emphasizing the necessity of precise material characterization and enhanced understanding of the layer sequencing effect for optimizing composite designs for impact mitigation. The integration of empirical data with simulation methods provides a comprehensive framework for optimizing composite designs in high-impact scenarios. In the general fields of materials science and impact engineering, the current research offers some guidance for practical applications, underscoring the need for detailed simulations to capture the high-strain-rate dynamic responses of multilayered composites. Full article
(This article belongs to the Special Issue Theoretical and Computational Investigation on Composite Materials)
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19 pages, 4914 KiB  
Article
Multiscale Analysis of Water Area, Level and Flow and Their Relationships for a Large Lake Connected to Rivers: A Case Study of Dongting Lake, China
by Shan Xu, Liang Zhai, Bin Zou and Huiyong Sang
Water 2024, 16(9), 1198; https://doi.org/10.3390/w16091198 (registering DOI) - 23 Apr 2024
Abstract
Exploring the different characteristics of water status at different time scales is essential for the understanding of the complex hydrological processes in lakes connected to rivers. Taking Dongting Lake, a large-scale lake connected to the Yangtze River, as an example, this study employed [...] Read more.
Exploring the different characteristics of water status at different time scales is essential for the understanding of the complex hydrological processes in lakes connected to rivers. Taking Dongting Lake, a large-scale lake connected to the Yangtze River, as an example, this study employed wavelet analysis and multiple models to explore the temporal characteristics of water area, level, and flow and the water level–area and flow–area correlations from 2000 to 2021 on annual, seasonal, and monthly scales. The results show that the interannual variations in annual, seasonal, and monthly water area anomalies demonstrated rather consistent overall trends, but there were differences in the variation ranges at different temporal scales. The dominant amplitudes for annual and seasonal area anomalies were close, while for monthly anomalies, they were sometimes much larger. The dominant amplitudes of the water level and flow anomalies generally followed the order annual < seasonal < monthly. The water level–area and flow–area correlations are strongest at Chenglingji station and on the seasonal scale. This study provides a multiscale perspective on hydrological conditions and will support the management of water resources and the prevention of drought and flood disasters. Full article
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11 pages, 3923 KiB  
Article
High Consistency Silicone Rubber Foams
by Timo Hofmann, Ralf-Urs Giesen and Hans-Peter Heim
Polymers 2024, 16(9), 1181; https://doi.org/10.3390/polym16091181 (registering DOI) - 23 Apr 2024
Abstract
Silicone elastomers are high-performance plastics. In the extrusion process, only high-consistency silicone rubbers were used. In order to reduce the cost and weight, silicone rubbers can be foamed during processing. In this study, high-consistency silicone rubber is processed with different physical and chemical [...] Read more.
Silicone elastomers are high-performance plastics. In the extrusion process, only high-consistency silicone rubbers were used. In order to reduce the cost and weight, silicone rubbers can be foamed during processing. In this study, high-consistency silicone rubber is processed with different physical and chemical blowing agents. The resulting reaction kinetics, as well as the mechanical and morphological properties, had been investigated and compared with each other. This showed that the chemical blowing agent significantly influenced the crosslinking reaction compared to the microspheres and the water/silica mixture tested, but it also achieved the lowest density compared to the physical blowing agents. When evaluating the foam morphology, it became clear that the largest number of pores was achieved with the microspheres and the largest pores when using the water/silica mixture. Furthermore, it has been shown that the different mechanisms of action of the blowing agents have a major influence on the mechanical properties, such as the micro shore hardness and the foam morphology. Full article
(This article belongs to the Special Issue Advances in Rubbers)
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16 pages, 4480 KiB  
Article
Toward a More Robust Estimation of Forest Biomass Carbon Stock and Carbon Sink in Mountainous Region: A Case Study in Tibet, China
by Guanting Lyu, Xiaoyi Wang, Xieqin Huang, Jinfeng Xu, Siyu Li, Guishan Cui and Huabing Huang
Remote Sens. 2024, 16(9), 1481; https://doi.org/10.3390/rs16091481 (registering DOI) - 23 Apr 2024
Abstract
Mountainous forests are pivotal in the global carbon cycle, serving as substantial reservoirs and sinks of carbon. However, generating a reliable estimate remains a considerable challenge, primarily due to the lack of representative in situ measurements and proper methods capable of addressing their [...] Read more.
Mountainous forests are pivotal in the global carbon cycle, serving as substantial reservoirs and sinks of carbon. However, generating a reliable estimate remains a considerable challenge, primarily due to the lack of representative in situ measurements and proper methods capable of addressing their complex spatial variation. Here, we proposed a deep learning-based method that combines Residual convolutional neural networks (ResNet) with in situ measurements, microwave (Sentinel-1 and VOD), and optical data (Sentinel-2 and Landsat) to estimate forest biomass and track its change over the mountainous regions. Our approach, integrating in situ measurements across representative elevations with multi-source remote sensing images, significantly improves the accuracy of biomass estimation in Tibet’s complex mountainous forests (R2 = 0.80, root mean squared error = 15.8 MgC ha−1). Moreover, ResNet, which addresses the vanishing gradient problem in deep neural networks by introducing skip connections, enables the extraction of complex spatial patterns from limited datasets, outperforming traditional optical-based or pixel-based methods. The mean value of forest biomass was estimated as 162.8 ± 21.3 MgC ha−1, notably higher than that of forests at comparable latitudes or flat regions in China. Additionally, our findings revealed a substantial forest biomass carbon sink of 3.35 TgC year−1 during 2015–2020, which is largely underestimated by previous estimates, mainly due to the underestimation of mountainous carbon stock. The significant carbon density, combined with the underestimated carbon sink in mountainous regions, emphasizes the urgent need to reassess mountain forests to better approximate the global carbon budget. Full article
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14 pages, 5058 KiB  
Article
A Novel Approach to Raman Distributed Temperature-Sensing System for Short-Range Applications
by Augusto Pieracci, Jacopo Nanni, Giovanni Tartarini and Massimo Lanzoni
Sensors 2024, 24(9), 2669; https://doi.org/10.3390/s24092669 (registering DOI) - 23 Apr 2024
Abstract
A novel approach to the development of Distributed Temperature-Sensing (DTS) systems based on Raman Scattering in Multimode optical fibers operating at around 800 nm is presented, focusing on applications requiring temperature profile measurement in the range of a few hundreds of meters. In [...] Read more.
A novel approach to the development of Distributed Temperature-Sensing (DTS) systems based on Raman Scattering in Multimode optical fibers operating at around 800 nm is presented, focusing on applications requiring temperature profile measurement in the range of a few hundreds of meters. In contrast to the standard Raman DTS systems, which aim to shorten the pulse space width as much as possible to improve the precision of measurement, the novel approach studied in this work is based on the use of pulses with a space width that is approximately equal to the distance covered by the fiber under test. The proposed technique relies on numerical post-processing to obtain the temperature profile measurement with a precision of about ±3 °C and a spatial resolution of 8 m, due to the transaction phases of the optical pulses. This solution simplifies the electronic circuit development, also minimizing the required laser peak power needed compared to the typical narrow pulse techniques. Full article
(This article belongs to the Special Issue Advances in the Design and Application of Optical Fiber Sensors)
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