The measurement of the longitudinal rail profile is relevant to the condition monitoring of the rail infrastructure. The running surface is recognizable as a shiny metallic area on top of the rail head. The detection of the running surface is crucial for vehicle-based rail profile measurements, as well as for defect detection. This paper presents a methodology for the automatic detection of the running surface based on a laser profilometer. The detection of the running surface is performed based on the light reflected from the rail surface. Three rail surfaces with different surface conditions are considered. Supervised machine learning is applied to classify individual surface elements as part of the running surface. Detection by a linear support vector machine is performed with accuracy of >$90\%$. The lateral position of the running surface and its width are calculated. The average deviation from the labeled widths varies between $-1.2$$\mathrm{m}$$\mathrm{m}$ and $5.6$$\mathrm{m}$$\mathrm{m}$. The proposed measurement approach could be installed on a train for the future onboard monitoring of the rail network. Full article

The use of agricultural chemicals has adversely affected soil health and the environment. Organic farming practices, particularly vermicompost (VC), are gaining attention for their potential to improve soil fertility and crop productivity. This study investigated VC rate applications on lettuce growth, yield, soil fertility, nutrient dynamics, enzyme activity, biological parameters, and biochemical aspects under greenhouse conditions in Samsun, Turkey during 2022–2023. Experimentally, VC was applied at rates of V1: 1%, V2: 2%, and V3: 4% w/w, with a control group without VC application, V0: 0% w/w. Batavia lettuce, which is sensitive to environmental conditions and nutrient deficiency, was subjected to these treatments in a randomized complete block design, replicated thrice. Results showed consistent improvements in plant dry weight across all VC treatments, with the 2% application rate (V2) yielding the highest increase in lettuce yield (56.43%). Soil pH varied across treatments, with V1 being slightly alkaline and V3 showing high electrical conductivity and increased nitrogen content. Phosphorus content increased in all treatments, while potassium varied, with V3 having the highest values. Soil enzyme activities increased with VC concentrations, with V3 showing the highest urease activity. Pearson correlations confirmed positive associations with growth parameters and soil enzymatic activity. These findings highlight vermicompost as a sustainable solution for lettuce production and soil improvement. Full article

As gluten may trigger gastrointestinal disorders (GIDs), its presence or absence in the diet can change the diversity and proportion of gut microbiota. The effects of gluten after six weeks of a double-blind, placebo-controlled intervention with a gluten-free diet (GFD) were studied in participants with GIDs suffering from migraines and atopic dermatitis (n = 46). Clinical biomarkers, digestive symptoms, stool, the Migraine Disability Assessment questionnaire, and zonulin levels were analyzed. Next-generation sequencing was used to amplify the 16S rRNA gene of bacteria and the internal transcribed spacer (ITS) regions of fungi. The GFD increased Chao1 fungal diversity after the intervention, while the fungal composition showed no changes. Bacterial diversity and composition remained stable, but a positive association between bacterial and fungal Chao1 diversity and a negative association between Dothideomycetes and Akkermansia were observed. GIDs decreased in both groups and migraines improved in the placebo group. Our findings may aid the development of GID treatment strategies. Full article

Automated and seamless integration of reinforcement is one of the main unresolved challenges in large-scale additive construction. This study leverages a dual-reinforcement solution consisting of high-dosage steel fiber (up to 2.5% by volume) and short vertical reinforcements as a complementary reinforcement technique for 3D-printed elements. The mechanical performance of the printing material was characterized by measuring the compressive, flexural, and uniaxial tensile strengths of mold-cast specimens. Furthermore, the flexural performance of the plain and fiber-reinforced 3D-printed beams was evaluated in the three main loading directions (X, Y, and Z-directions in-plane). In addition, short vertical threaded reinforcements were inserted into the fiber-reinforced 3D-printed beams tested in the Z-direction. The experimental results revealed the superior flexural performance of the fiber-reinforced beams loaded in the longitudinal directions (X and Y). Moreover, the threaded reinforcement significantly increases the flexural strength and ductility of beams loaded along the interface, compared to the control. Overall, the proposed dual-reinforcement approach, which exhibited notably less porosity compared to the mold-cast counterpart, holds great potential as a reinforcement solution for 3D-printed structures without the need for manual operations. Full article

This paper provides a study of two bone substitutes: a hybrid porous polymer and an osteoplastic matrix based on a bovine-derived xenograft. Both materials are porous, but their pore characteristics are different. The osteoplastic matrix has pores of 300–600 µm and the hybrid polymer has smaller pores, generally of 6–20 µm, but with some pores up to 100 µm across. SEM data confirmed the porometry results and demonstrated the different structures of the materials. Therefore, both materials were characterized by an interconnected porous structure and provided conditions for the adhesion and vital activity of human ASCs in vitro. In an experimental model of rabbit shin bone defect, it was shown that, during the 6-month observation period, neither of the materials caused negative reactions in the experimental animals. By the end of the observation period, restoration of the defects in animals in both groups was completed, and elements of both materials were preserved in the defect areas. Data from morphological examinations and CT data demonstrated that the rate of rabbit bone tissue regeneration with the hybrid polymer was comparable to that with the osteoplastic matrix. Therefore, the hybrid polymer has good potential for use in further research and improvement in biomedical applications. Full article

Salt marshes play a critical role in supporting water quality, erosion control, flood protection, and carbon sequestration. Threats from climate change and human activities have prompted global restoration initiatives. We analyzed restoration efforts worldwide from 1978 to 2022, using the Web of Science database and SciMAT mapping tool. After a PRISMA screening to identify methodologies, success rates, and key indicators, a total of 62 publications underwent detailed analysis, to increase knowledge on the best practices to employ in future restoration interventions and evaluation of their effectiveness. The research reveals a growing interest in ecosystem dynamics, biodiversity, anthropogenic impacts, and ecosystem services. Assisted interventions emerged as the predominant restoration method, employing 15 indicators across vegetation, sediment, fauna, and water, each one using different metrics for the intervention evaluation based on how good the outcome of the interventions described in the reviewed studies met the desired result. Our analysis suggests that combining natural interventions such as managed realignment with reconnection to tidal waters, along with long-term monitoring of vegetation, fauna, and water indicators such as sedimentation and erosion rates, plant cover and biomass, as well as fauna diversity and density, leads to the most successful outcomes. We provide valuable insights into best practices for future restoration interventions, offering guidance to future practitioners and policymakers based on a comprehensive review of the scientific literature, contributing to the resilience of these vital ecosystems, and ensuring effective restoration actions in the coming years. Full article

Background: This study aimed to evaluate the association between the dietary intake of vitamin B complex (thiamine, riboflavin, and niacin) and cervical cancer in Korea. Methods: The data from the Korean National Health and Nutrition Examination Survey (KNHANES) from 2010 to 2021 were analyzed, which included 28,306 participants who were categorized into non-cervical cancer and cervical cancer groups. The following dietary intake threshold levels of thiamine, riboflavin, and niacin were identified based on the recommended daily allowances (RDAs): thiamine, 1.1 mg/day; riboflavin, 1.2 mg/day; and niacin, 14 mg/day. Results: Among 28,306 participants, 27,976 were in the non-cervical cancer group and 330 were in the cervical cancer group. Riboflavin intakes of more than 1.2 mg/day but less than 2.4 mg/day were associated with a significantly reduced risk of cervical cancer, whereas intakes of above 2.4 mg/day were not associated with cervical cancer. Thiamine and niacin intakes were not significantly related to the risk of cervical cancer. Conclusions: The results of this study suggest that an intake of riboflavin of 1.2–2.4 mg/day may contribute to a lower risk of cervical cancer. Full article

Up to 80% of patients under immune checkpoint inhibitors (ICI) face resistance. In this context, stereotactic ablative radiotherapy (SABR) can induce an immune or abscopal response. However, its molecular determinants remain unknown. We present early results of a translational study assessing biomarkers of response to combined ICI and SABR (I-SABR) in liquid biopsy from oligoprogressive patients in a prospective observational multicenter study. Cohort A includes metastatic patients in oligoprogression to ICI maintaining the same ICI due to clinical benefit and who receive concomitant SABR. B is a comparative group of oligometastatic patients receiving only SABR. Blood samples are extracted at baseline (T1), after the first (T2) and last (T3) fraction, two months post-SABR (T4) and at further progression (TP). Response is evaluated by iRECIST and defined by the objective response rate (ORR)—complete and partial responses. We assess peripheral blood mononuclear cells (PBMCs), circulating cell-free DNA (cfDNA) and small RNA from extracellular vesicles. Twenty-seven patients could be analyzed (cohort A: n = 19; B: n = 8). Most were males with non-small cell lung cancer and one progressing lesion. With a median follow-up of 6 months, the last ORR was 63% (26% complete and 37% partial response). A decrease in cfDNA from T2 to T3 correlated with a good response. At T2, CD8+PD1+ and CD8+PDL1+ cells were increased in non-responders and responders, respectively. At T2, 27 microRNAs were differentially expressed. These are potential biomarkers of response to I-SABR in oligoprogressive disease. Full article

Aryl hydrocarbon receptor (AHR), a transcription factor activated by many natural and synthetic ligands, represents an important mediator of the interplay between the environment and the host’s immune responses. In a healthy gut, AHR activation promotes tolerogenic signals, which help maintain mucosal homeostasis. AHR expression is defective in the inflamed gut of patients with inflammatory bowel diseases (IBD), where decreased AHR signaling is supposed to contribute to amplifying the gut tissue’s destructive immune–inflammatory responses. We here review the evidence supporting the role of AHR in controlling the “physiological” intestinal inflammation and summarize the data about the therapeutic effects of AHR activators, both in preclinical mouse models of colitis and in patients with IBD. Full article

The purpose of this research is to examine whether Buddhist ethics can improve the health and well-being of Buddhist practitioners during pandemics like COVID-19. It is hypothesized that diseases are part of suffering, and Buddhist teachings aim to eliminate the suffering of all beings. Buddhism also offers ethical codes of conduct for its practitioners to improve their health and well-being. So, the Buddha’s teaching or Buddhist ethics, when practiced seriously, should be able to improve one’s health, physically and mentally, enhancing the well-being of all Buddhist practitioners during the spread of all pandemics including COVID-19. The present study found that Buddhist ethical practices like the chanting of Buddhist suttas and the development of mindfulness, concentration/meditation, and insight (vipassanā) can improve both physical and mental health, which are important for dealing with any pandemic, tremendously. If the cores of Buddhist ethics (morality, meditation, and wisdom) are perfectly practiced, not only will one live with good physical and mental health but one also will be able to eliminate all the mental defilements that are the root causes of all illnesses and thus enter nibbāna, the state of mind that is beyond all sources of suffering including pandemics/epidemics. More specifically, this paper highlights a set of Buddhist practices, called four bhāvanās (types of development), that can be used to improve health and well-being during any pandemic. Full article

Background: Endotamponade of the vitreous body with silicone oil is a common procedure, being the basis of many vitreoretinal surgeries. However, emulsification may happen, which is a clinically relevant adverse event of silicone oil use. Methods: This review provides a thorough analysis of the emulsification process. It focuses on describing factors affecting this event as well as its possible subsequent complications. Results: The viscosity of silicone oil, the duration of emulsification, the status of the lens and many other factors have an influence on the onset and intensity of emulsification. This phenomenon carries several risks for operated eyes such as increased intraocular pressure, keratopathy or structural changes to the retina. Conclusions: The use of modern imaging techniques, especially optical coherence tomography, enables faster detection of the emulsification process. This allows for an adequate clinical response and more accurate follow-up of the patient. Full article

In this paper, we introduce an ODE system to model the interaction between natural resources and human exploitation in a rich consumeristic society. In this model, the rate of change in population depends on wealth per capita, and the rate of consumption has a quadratic growth with respect to population and wealth. We distinguish between renewable and non-renewable resources, and we introduce a replenishment term for non-renewable resources. We first obtain some information on the asymptotic behavior of wealth and population, then we compute all system equilibria and study their stability when the resource exploitation parameter is low. Some numerical simulations confirm the theoretical results and suggest directions for future research. Full article

Leaf samples of 226 cultivated olive trees were collected from traditionally managed olive orchards and genotyped with eleven consensual SSR markers. The proportion of shared allele distance was used for the estimation of distances between olive genotypes. Cluster analyses were performed using a Fitch–Margoliash least-squares algorithm. The number of different genetic subgroups of olive genotypes (K) was investigated using STRUCTURE analysis. The standardization of allele lengths was performed to enable the comparison SSR profiles of Croatian olive genotypes with olive profiles obtained with the same SSR primers in OleaDB and WOGB databases. Overall, 73 SSR profiles of known Croatian varieties and 53 profiles of unknown olive genotypes were differentiated. Synonyms were detected in 18 varieties, and we found intra-varietal differences in 15 varieties. Three genetic subgroups of olive genotypes were determined. Following allele length standardization achieved using nine referral samples, the genetic profiles of 126 cultivated olive genotypes were compared to OleaDB and WOGB databases, out of which 92 genotypes were found to be unique to Croatian olive germplasm. The results revealed the wide genetic diversity of olive germplasm beyond the known, registered varieties. The FAZ_oliveDB database containing the profiles of 126 Croatian olive genotypes was created and made available for public use. Full article

This study aims to develop an adaptable home energy management system capable of integrating the bidirectional smart charging of electric vehicles. The final goal is to achieve a user-defined objectives such as cost minimization or maximizing renewable self-consumption. Industrialwise, the present work yields valuable outcomes in identifying operational frameworks and boundary conditions. Optimal scheduling benefits both users and the electric network, thus enhancing grid utilization and increasing renewable energy integration. By coordinating power interactions with dynamic time-of-use tariffs, the energy management system minimizes user costs and aids the grid by cutting peak hour energy consumption. Charging and discharging operations in electric vehicles comply with energy level constraints outlined by bidirectional charging protocols. The proposed approach ensures the scheduling of cycles that minimize detrimental effects on battery health when evaluating an economically ageing mechanism. Compared to uncontrolled charging, optimal scheduling resulted in a significant reduction in the total operational cost of the dwelling. Trade-off conditions between renewable integration and potential savings are identified and numerically evaluated by means of multiobjective optimization. In contrast to scheduling-based models, the proposed architecture possesses the ability to iteratively adapt decision variables in response to system changes, thus responding effectively to external stochastic uncertainty. Full article

As a crucial basic natural resource, water resources are the cornerstone for sustainable national economic development. This paper takes the 2014 pilot water rights trading policy (WRT) as an entry point and uses a difference-in-differences (DID) model to test the policy effect of WRT on water-use efficiency (WUE) based on data for 30 Chinese provinces from 2005 to 2021. The study shows that WRT can significantly improve the regional WUE, and these results remain valid after a series of robustness tests, such as the parallel trend test, placebo test, and PSM-DID. Mechanistic analysis revealed that WRT can produce the Porter effect, which affects the WUE through technological innovation. The results of the heterogeneity analysis based on the synthetic control method (SCM) showed that WRT effectively improved WUE in Jiangxi, Henan, Ningxia, Hubei, and Guangdong, but did not achieve the expected effect in Inner Mongolia or Gansu. This paper provides solid empirical support for assessing the effectiveness of WRT and accelerating the process of establishing a unified national WRT market in China by 2025. Full article

In breeding programs, the demand for high-throughput phenotyping is substantial as it serves as a crucial tool for enhancing technological sophistication and efficiency. This advanced approach to phenotyping enables the rapid and precise measurement of complex traits. Therefore, the objective of this study was to estimate the correlation between vegetation indices (VIs) and grain yield and to identify the optimal timing for accurately estimating yield. Furthermore, this study aims to employ photographic quantification to measure the characteristics of corn ears and establish their correlation with corn grain yield. Ten corn hybrids were evaluated in a Complete Randomized Block (CRB) design with three replications across three locations. Vegetation and green leaf area indices were estimated throughout the growing cycle using an unmanned aerial vehicle (UAV) and were subsequently correlated with grain yield. The experiments consistently exhibited high levels of experimental quality across different locations, characterized by both high accuracy and low coefficients of variation. The experimental quality was consistently significant across all sites, with accuracy ranging from 79.07% to 95.94%. UAV flights conducted at the beginning of the crop cycle revealed a positive correlation between grain yield and the evaluated vegetation indices. However, a positive correlation with yield was observed at the V5 vegetative growth stage in Lavras and Ijaci, as well as at the V8 stage in Nazareno. In terms of corn ear phenotyping, the regression coefficients for ear width, length, and total number of grains (TNG) were 0.92, 0.88, and 0.62, respectively, demonstrating a strong association with manual measurements. The use of imaging for ear phenotyping is promising as a method for measuring corn components. It also enables the identification of the optimal timing to accurately estimate corn grain yield, leading to advancements in the agricultural imaging sector by streamlining the process of estimating corn production. Full article

This article presents the results of tests carried out to assess the condition of PP-modified concrete. The tests were carried out on samples previously stored at ambient temperature and exposed to temperatures corresponding to fire conditions—300 °C, 450 °C, and 600 °C. Axial compression tests of cube-shaped samples and three-point bending of beams were carried out. During strength tests, acoustic emission (AE) signals were recorded and the force and deformation were measured. Recorded AE events were clustered using the k-means algorithm. The analysis of the test results allowed for the identification of signals characteristic of the individual stages of the material destruction process. Differences in the methods of destruction of samples stored in ambient conditions and those exposed to fire temperatures were also indicated. While loading the samples, measurements were carried out using the digital image correlation (DIC) method, which enabled the determination of displacements. Based on the results of the laboratory tests, a numerical model was developed. The results obtained using different research methods (DIC and FEM) were compared. Tomographic examinations and observations of the microstructure of the tested materials were also carried out. The analyses carried out allowed for a reliable assessment of the possibility of using the acoustic emission method to detect destructive processes and assess the technical condition of PP-modified concrete. It was confirmed that the acoustic emission method, due to differences at low load levels, can be a useful technique for assessing the condition of PP-modified concrete after exposure to fire temperatures. So far, no research directions in a similar field have been identified. Full article

With the increasing concern about antimony (Sb) pollution and remediation in aquatic ecosystems, more and more feasible technologies have been developed. Adsorption has been extensively studied due to the simplicity of its operation and its minimal environmental effects, but the lack of cheap and stable adsorbents has limited its application in Sb treatment. In this study, pseudo-boehmite (PB) was successfully synthesized via aluminum isopropylate hydrolysis, and its potential for removing Sb(V) from wastewater was explored. The removal efficiency of Sb(V) was 92.50%, and the maximum adsorption capacity was 75.25 mg/g under optimal conditions (pH 5.0, 2 g·L⁻¹ PB, and 10 mg·L⁻¹ Sb(V)). In addition, better performance could be obtained at acidic conditions (pH 3.0–5.0). Surface complexation, electrostatic attraction, and hydrogen bonding were identified as potential major processes for Sb(V) elimination by PB based on experimental and characterization data. This study presents a promising approach for the efficient removal of Sb(V) from wastewater, offering a new insight into the application of aluminum-based materials for heavy metal removal. Full article

This systematic review critically evaluates the impact of systemic treatments on outcomes and quality of life (QoL) in patients with RAS-positive stage IV colorectal cancer, with studies published up to December 2023 across PubMed, Scopus, and Web of Science. From an initial pool of 1345 articles, 11 relevant studies were selected for inclusion, encompassing a diverse range of systemic treatments, including panitumumab combined with FOLFOX4 and FOLFIRI, irinotecan paired with panitumumab, regorafenib followed by cetuximab ± irinotecan and vice versa, and panitumumab as a maintenance therapy post-induction. Patient demographics predominantly included middle-aged to elderly individuals, with a slight male predominance. Racial composition, where reported, showed a majority of Caucasian participants, highlighting the need for broader demographic inclusivity in future research. Key findings revealed that the addition of panitumumab to chemotherapy (FOLFOX4 or FOLFIRI) did not significantly compromise QoL while notably improving disease-free survival, with baseline EQ-5D HSI mean scores ranging from 0.76 to 0.78 and VAS mean scores from 70.1 to 74.1. Improvements in FACT-C scores and EQ-5D Index scores particularly favored panitumumab plus best supportive care in KRAS wild-type mCRC, with early dropout rates of 38–42% for panitumumab + BSC. Notably, cetuximab + FOLFIRI was associated with a median survival of 25.7 months versus 16.4 months for FOLFIRI alone, emphasizing the potential benefits of integrating targeted therapies with chemotherapy. In conclusion, the review underscores the significant impact of systemic treatments, particularly targeted therapies and their combinations with chemotherapy, on survival outcomes and QoL in patients with RAS-positive stage IV colorectal cancer, and the need for personalized treatment. Full article

Over the years, the tourism sector has constantly been a driving force in strengthening the Greek economy. Therefore, being capable of leveraging a tourism business’s performance can be of great importance in many aspects for destinations and destination management and marketing organizations (DMMOs). For this very purpose, this study’s methodology consists of a combined application of the key performance indicators and data envelopment analysis. The research conducted is quantitative, aiming to analyze the efficiency of the Greek hotels by region and determine the effective ones, as well as the strategic and managerial changes which should be considered by the non-effective. As a result, it shall become possible for each set of hotels to know the ideal turnover and the tourism nights spent that they should achieve, based on their current capacity in terms of beds and employees. Ultimately, this process could play a pivotal role in a region’s strategic planning, both from a resource management perspective, as well as in establishing an effective, measurable strategy that can be implemented by regional policy makers and destination managers in a real-time benchmarking process. Full article

This study delves into the integration of analytic hierarchy process (AHP) and geographic information system (GIS) techniques to identify suitable areas for urban development in six districts within the Mersin Metropolitan Area of Turkey. The specific aim is to generate an urban land use suitability map, in order to facilitate informed decision-making for urban development. Drawing on open Landsat satellite imagery and employing the random forest (RF) algorithm, the study spans a fifteen-year period, over which land use/land cover (LULC) changes are measured. Furthermore, a novel approach is introduced by incorporating the urban land use suitability map into an urban growth simulation model developed using a logistic regression (LR) algorithm. This simulation forecasts urban growth up to 2027, enabling planners to evaluate potential development areas against suitability criteria. Findings reveal spatial patterns of land suitability and projected urban growth, aiding decision-makers in selecting optimal areas for development while preserving ecological integrity. Notably, the study emphasizes the importance of considering various factors such as topography, accessibility, soil capability, and geology in urban planning processes. The results showcase significant proportions of the study area as being moderately to highly suitable for urban development, alongside notable shifts in LULC classes over the years. Additionally, the overlay analysis of simulated urban growth and land suitability maps highlights areas with contrasting suitability levels, offering valuable insights for sustainable urban growth strategies. By overlaying the urban land suitability map with a simulated LULC map for 2027, it is revealed that 2247.3 hectares of potential new urbanization areas demonstrate very high suitability for settlement, while 7440.12 hectares exhibit very low suitability. By providing a comprehensive framework for assessing urban land suitability and projecting future growth, this research offers practical implications for policymakers, urban planners, and stakeholders involved in Mersin’s development trajectory, ultimately fostering more sustainable and resilient urban landscapes. Full article

Environmental flow assessment is an essential tool in water resource management. This study employs a holistic approach to evaluate the environmental flow in the Yen Basin, Thanh Hoa, Vietnam. Based on information gathered from a field survey, the Yen River system is divided into five reaches, and environmental objectives and ecological assets are identified in each reach. Hydrological and hydraulic mathematical models are applied to simulate the flow regime in the river, demonstrating their potential to assess environmental flow, especially in basins with limited data. The detailed results from the mathematical model facilitate selecting environmental flow components to address specific objectives for each river reach. By analyzing and selecting the flow regime, this study aims to ensure environmental protection while also considering basin development requirements, laying the groundwork for defining prescribed flow regimes in basin water management. Full article