ATP-binding cassette (ABC) transporters play a crucial role for the efflux of a wide range of substrates across different cellular membranes. In the central nervous system (CNS), ABC transporters have recently gathered significant attention due to their pivotal involvement in brain physiology and neurodegenerative disorders, such as Alzheimer’s disease (AD). Glial cells are fundamental for normal CNS function and engage with several ABC transporters in different ways. Here, we specifically highlight ABC transporters involved in the maintenance of brain homeostasis and their implications in its metabolic regulation. We also show new aspects related to ABC transporter function found in less recognized diseases, such as Huntington’s disease (HD) and experimental autoimmune encephalomyelitis (EAE), as a model for multiple sclerosis (MS). Understanding both their impact on the physiological regulation of the CNS and their roles in brain diseases holds promise for uncovering new therapeutic options. Further investigations and preclinical studies are warranted to elucidate the complex interplay between glial ABC transporters and physiological brain functions, potentially leading to effective therapeutic interventions also for rare CNS disorders. Full article

Traumatic brain injury (TBI) stands as a prominent global cause of disability, with motor deficits being a common consequence. Despite its widespread impact, the precise pathological mechanisms underlying motor deficits after TBI remain elusive. In this study, hindlimb postural asymmetry (HL-PA) development in rats subjected to focal TBI was investigated to explore the potential roles of collagen IV and laminin within the extracellular matrix (ECM) of selected hindlimb muscles in the emergence of motor deficits following TBI. A focal TBI was induced by ablating the left sensorimotor cortex in rats and motor deficits were assessed by measuring HL-PA. The expression of laminin and collagen IV in eight selected muscles on each side of the hindlimbs from both TBI- and sham-operated rats were studied using immunohistochemistry and semi-quantitatively analyzed. The results indicated that the TBI rats exhibited HL-PA, characterized by flexion of the contralateral (right) hindlimb. In the sham-operated rats, the immunoreactive components of laminin and collagen IV were evenly and smoothly distributed along the border of the muscle fibers in all the investigated muscles. In contrast, in the TBI rats, the pattern was broken into aggregated, granule-like, immunoreactive components. Such a labeling pattern was detected in all the investigated muscles both from the contra- and ipsilateral sides of the TBI rats. However, in TBI rats, most of the muscles from the contralateral hindlimb showed a significantly increased expression of these two proteins in comparison with those from the ipsilateral hindlimb. In comparison to sham-operated rats, there was a significant increase in laminin and collagen IV expression in various contralateral hindlimb muscles in the TBI rats. These findings suggest potential implications of laminin and collagen IV in the development of motor deficits following a focal TBI. Full article

Early pubertal development induces early sexual activities among adolescents. In Ghana, despite the high sexual activity among Ghanaian adolescents, sexual and reproductive health (SRH) services are underutilised, primarily due to SRH stigma and a lack of SRH knowledge and information. This study examined the use of SRH services among adolescents aged 15–19 years in Ghana over a ten year period. The study utilised data from the 2007 and 2017 Ghana Maternal Health Surveys (GMHSs). Responses from 2056 and 4909 adolescent females captured in the 2007 and 2017 GMHSs, respectively, were used. The results showed a declining utilisation of SRH services among adolescents from 28.3% in 2007 to 22.5% in 2017. The odds of using family planning among sexually active adolescents increased from 2007 [AOR-0.32, CI-(0.135, 0.77), p < 0.001] to 2017 [AOR-68.62, CI-(36.104, 130.404), p < 0.001]. With increasing age at first sex, adolescents were less likely to use a family planning method in 2007 [AOR-0.94, CI-(0.89,0.99) p < 0.001], but this improved in 2017 [AOR-1.26, CI-(1.220, 1.293), p < 0.001]. Despite this, knowledge of sources for family planning was found to predict its lower utilisation in both 2007 [AOR = 0.15 (95% CI-0.081, 0.283), p < 0.0001] and 2017 [AOR = 0.206 (95% CI-(0.099, 0.426), p < 0.001]. The findings show that even though knowledge of family planning methods predicted low utilisation, knowledge of sources, age at first sex, and educational level positively predicted the utilisation of SRH services from 2007 to 2017. Opportunities for both enhancing the clinical environment and health provider attitudes exist and should be explored for improving SRH outcomes among sexually active adolescents in Ghana. Full article

In our research, we explored a natural substance called Oxymatrine, found in a traditional Chinese medicinal plant, to fight against a common bird flu virus known as H9N2. This virus not only affects birds but can also pose a threat to human health. We focused on how this natural compound can help in stopping the virus from spreading in cells that line the lungs of birds and potentially humans. Our findings show that Oxymatrine can both directly block the virus and boost the body’s immune response against it. This dual-action mechanism is particularly interesting because it indicates that Oxymatrine might be a useful tool in developing new ways to prevent and treat this type of bird flu. Understanding how Oxymatrine works against the H9N2 virus could lead to safer and more natural ways to combat viral infections in animals and humans, contributing to the health and well-being of society. The H9N2 Avian Influenza Virus (AIV) is a persistent health threat because of its rapid mutation rate and the limited efficacy of vaccines, underscoring the urgent need for innovative therapies. This study investigated the H9N2 AIV antiviral properties of Oxymatrine (OMT), a compound derived from traditional Chinese medicine, particularly focusing on its interaction with pulmonary microvascular endothelial cells (PMVECs). Employing an array of in vitro assays, including 50% tissue culture infectious dose, Cell Counting Kit-8, reverse transcription-quantitative polymerase chain reaction, enzyme-linked immunosorbent assay, and Western blot, we systematically elucidated the multifaceted effects of OMT. OMT dose-dependently inhibited critical antiviral proteins (PKR and Mx1) and modulated the expression of type I interferons and key cytokines (IFN-α, IFN-β, IL-6, and TNF-α), thereby affecting TLR3 signaling and its downstream elements (NF-κB and IRF-3). OMT’s antiviral efficacy extended beyond TLR3-mediated responses, suggesting its potential as a versatile antiviral agent. This study not only contributes to the growing body of research on the use of natural compounds as antiviral agents but also underscores the importance of further investigating the broader application of OMT for combating viral infections. Full article

We characterized the therapeutic biological modes of action of several terpenes in Poria cocos F.A Wolf (PC) and proposed a broad therapeutic mode of action for PC. Molecular docking and drug-induced transcriptome analysis were performed to confirm the pharmacological mechanism of PC terpene, and a new analysis method, namely diffusion network analysis, was proposed to verify the mechanism of action against Alzheimer’s disease. We confirmed that the compound that exists only in PC has a unique mechanism through statistical-based docking analysis. Also, docking and transcriptomic analysis results could reflect results in clinical practice when used complementarily. The detailed pharmacological mechanism of PC was confirmed by constructing and analyzing the Alzheimer’s disease diffusion network, and the antioxidant activity based on microglial cells was verified. In this study, we used two bioinformatics approaches to reveal PC’s broad mode of action while also using diffusion networks to identify its detailed pharmacological mechanisms of action. The results of this study provide evidence that future pharmacological mechanism analysis should simultaneously consider complementary docking and transcriptomics and suggest diffusion network analysis, a new method to derive pharmacological mechanisms based on natural complex compounds. Full article

This paper endeavours to investigate whether a complex tax system influences firms’ propensity toward tax evasion across countries. To achieve the objectives of this study, we utilised the World Bank Enterprise Survey and the World Bank’s Doing Business databases covering more than 46,000 companies from 83 countries. Our study revealed that the increased time required to pay taxes and higher total tax payments were associated with a greater extent and incidence of tax evasion among firms. The consistency of these benchmark regression results was proven through endogeneity analysis and several robustness tests. Furthermore, our heterogeneity analyses showed that the effect of tax complexity on firm tax evasion was more prominent in low- and lower-middle-income countries and also in the primary industry. These findings offer promising evidence for policymakers, particularly in low- and lower-middle-income countries where the majority of companies operate in the primary industry. Addressing the complexity of the tax system could potentially mitigate the adverse impact on tax evasion levels in these countries. Furthermore, our spatial analysis provides valuable insights, emphasising the potential impact of tax complexity in neighbouring countries and underscoring the necessity for policymakers in the home countries to strategise on harmonising and streamlining their tax systems. Full article

The thermo- and pain-sensitive Transient Receptor Potential Melastatin 3 and 8 (TRPM3 and TRPM8) ion channels are functionally associated in the lipid rafts of the plasma membrane. We have already described that cholesterol and sphingomyelin depletion, or inhibition of sphingolipid biosynthesis decreased the TRPM8 but not the TRPM3 channel opening on cultured sensory neurons. We aimed to test the effects of lipid raft disruptors on channel activation on TRPM3- and TRPM8-expressing HEK293T cells in vitro, as well as their potential analgesic actions in TRPM3 and TRPM8 channel activation involving acute pain models in mice. CHO cell viability was examined after lipid raft disruptor treatments and their effects on channel activation on channel expressing HEK293T cells by measurement of cytoplasmic Ca²⁺ concentration were monitored. The effects of treatments were investigated in Pregnenolone-Sulphate-CIM-0216-evoked and icilin-induced acute nocifensive pain models in mice. Cholesterol depletion decreased CHO cell viability. Sphingomyelinase and methyl-beta-cyclodextrin reduced the duration of icilin-evoked nocifensive behavior, while lipid raft disruptors did not inhibit the activity of recombinant TRPM3 and TRPM8. We conclude that depletion of sphingomyelin or cholesterol from rafts can modulate the function of native TRPM8 receptors. Furthermore, sphingolipid cleavage provided superiority over cholesterol depletion, and this method can open novel possibilities in the management of different pain conditions. Full article

The influence of business incubation systems on family businesses in African economies has not been thoroughly investigated despite the potential contribution of family businesses to Africa’s economic expansion and the attainment of development goals outlined in the Africa Development Agenda 2063 and the Sustainable Development Goals. Therefore, this study investigates the potential benefits that family businesses in Africa can derive from engaging in business incubation. This study utilised an integrative literature review methodology to investigate the research question. Twenty-three peer-reviewed articles were systematically selected from the Scopus, Web of Science, and Google Scholar databases using the following combination of phrases: “family business” and either “business incubation” or “business incubator”. The findings suggest ways to create a mutually beneficial relationship between family businesses and business incubators to improve long-term sustainability, promote collaboration, facilitate knowledge transfer, and foster an entrepreneurial ecosystem. It also recognises challenges, such as cultural alignment in family businesses. Business incubators in Africa can improve the sustainability of family businesses, such as during the succession, by offering support, resources, and guidance. The South African experience is a role model for the rest of the continent, in this regard. Future research should broaden the sources beyond the three databases utilised, including non-peer-reviewed sources such as grey literature, and extend the focus beyond developing economies. Full article

With the implementation of China’s rural revitalization strategy, the sustainable preservation of traditional dwellings has become a research priority. Moreover, with the aging population in the countryside increasing, the limited mobility of the elderly may result in them receiving daily corneal illuminance too low for a healthy circadian stimulus. This work aims to explore the relationship between circadian and daylighting design parameters inside traditional dwellings and to develop easy-to-use methods for guiding indoor circadian design in traditional dwellings in western Hunan. Additionally, it seeks to promote the digitalization and informatization of traditional dwellings in western Hunan for preservation purposes, aiming to integrate these efforts with sustainable tourism and community development, which supports the local economy while preserving cultural heritage. The main contributions are as follows: (i) Systematic evaluation of the indoor lighting and circadian status of traditional Miao dwellings in western Hunan. (ii) Simplification and application of the CS and corneal illuminance fitting model for guiding circadian design, especially suitable for indirect indoor circadian aspects of lighting in daylight scenarios. The simplified model provides quick circadian design feedback and promotes healthy circadian concepts. Its accuracy has been verified by fitting it with simulation data from Climate Studio daylighting software. (iii) Exploration of daylighting conditions using simulation software, focusing on ρ′ (the area-weighted average of room surface reflectance), ρ (the reflectance of the surface where the first reflection occurs), and the WWR (Window-to-wall ratio) in two different types of traditional dwellings. This also includes defining the dwelling parameter intervals necessary for an appropriate circadian stimulus in traditional Miao dwellings in western Hunan. (iv) The analysis suggests that enhancing ρ′ has a greater effect on circadian lighting than WWR, indicating that increasing ρ′ should be the preferred method for achieving high-quality and efficient circadian lighting. Full article

This paper presents a novel approach to mind-wandering prediction in the context of webcam-based online learning. We implemented a Singular Value Decomposition (SVD)-based 1D temporal eye-signal extraction method, which relies solely on eye landmark detection and eliminates the need for gaze tracking or specialized hardware, then extract suitable features from the signals to train the prediction model. Our thorough experimental framework facilitates the evaluation of our approach alongside baseline models, particularly in the analysis of temporal eye signals and the prediction of attentional states. Notably, our SVD-based signal captures both subtle and major eye movements, including changes in the eye boundary and pupil, surpassing the limited capabilities of eye aspect ratio (EAR)-based signals. Our proposed model exhibits a 2% improvement in the overall Area Under the Receiver Operating Characteristics curve (AUROC) metric and 7% in the F1-score metric for ‘not-focus’ prediction, compared to the combination of EAR-based and computationally intensive gaze-based models used in the baseline study These contributions have potential implications for enhancing the field of attentional state prediction in online learning, offering a practical and effective solution to benefit educational experiences. Full article

Vulnerabilities are often accompanied by cyberattacks. CVE is the largest repository of open vulnerabilities, which keeps expanding. ATT&CK models known multi-step attacks both tactically and technically and remains up to date. It is valuable to correlate the vulnerability in CVE with the corresponding tactic and technique of ATT&CK which exploit the vulnerability, for active defense. Mappings manually is not only time-consuming but also difficult to keep up-to-date. Existing language-based automated mapping methods do not utilize the information associated with attack behaviors outside of CVE and ATT&CK and are therefore ineffective. In this paper, we propose a novel framework named VTT-LLM for mapping Vulnerabilities to Tactics and Techniques based on Large Language Models, which consists of a generation model and a mapping model. In order to generate fine-tuning instructions for LLM, we create a template to extract knowledge of CWE (a standardized list of common weaknesses) and CAPEC (a standardized list of common attack patterns). We train the generation model of VTT-LLM by fine-tuning the LLM according to the above instructions. The generation model correlates vulnerability and attack through their descriptions. The mapping model transforms the descriptions of ATT&CK tactics and techniques into vectors through text embedding and further associates them with attacks through semantic matching. By leveraging the knowledge of CWE and CAPEC, VTT-LLM can eventually automate the process of linking vulnerabilities in CVE to the attack techniques and tactics of ATT&CK. Experiments on the latest public dataset, ChatGPT-VDMEval, show the effectiveness of VTT-LLM with an accuracy of 85.18%, which is 13.69% and 54.42% higher than the existing CVET and ChatGPT-based methods, respectively. In addition, compared to fine-tuning without outside knowledge, the accuracy of VTT-LLM with chain fine-tuning is 9.24% higher on average across different LLMs. Full article

Shared micromobility services have become increasingly prevalent and indispensable as a means of transportation across diverse geographical regions. Integrating shared micromobility with public transit offers opportunities to complement fixed-route transit networks and address first- and last-mile issues. To explore this topic, a systematic literature review was conducted to consolidate knowledge, analyze research achievements and best practices, and provide future research recommendations. This study examined 108 journal papers from the Web of Science (WoS) core collection from 2016 to 2022, along with grey literature. Citation and co-citation analyses were performed to build and illustrate the literature’s bibliometric networks. This analysis categorized the literature into four major study themes: policy, sustainability, the interaction between shared micromobility and public transportation, and infrastructure. The implementation approaches of integrating shared micromobility and public transportation in different cities were classified into four categories: physical integration, payment and fee integration, informational integration, and institutional integration. The findings indicate that the relationship between shared micromobility and public transportation varies with spatial–temporal conditions and the population density of the city. Overall, integrating micromobility into public transit can offer faster and more cost-effective mobility options for most trips, contributing to urban resilience, a better air quality, lower greenhouse gas emissions, and livable communities. Based on these insights, further research is recommended to explore dynamic and context-specific strategies for successful shared micromobility and public transit integration, considering diverse urban settings and demographic factors. Full article

In this paper, we present a novel three-dimensional (3D) coupled configuration of piezoelectric micromachined ultrasound transducers (pMUTs) by combing a curved and an annular diaphragm for transmit performance optimization in biomedical applications. An analytical equivalent circuit model (EQC) is developed with varied excitation methods to incorporate the acoustic–structure coupling of the curved and annular diaphragm-coupled pMUTs (CAC-pMUTs). The model-derived results align well with the reference simulated by the finite element method (FEM). Using this EQC model, we optimize the key design parameters of the CAC-pMUTs in order to improve the output sound pressure, including the width of the annular membrane, the thickness of the passive layer, and the phase difference of the driving voltage. In the anti-phase mode, the designed CAC-pMUTs demonstrate a transmit efficiency 285 times higher than that of single annular pMUTs. This substantial improvement underscores the potential of CAC-pMUTs for large array applications. Full article

The number of international students in South Korea, which dropped sharply during the COVID-19 pandemic, reached its highest level in 2023. It is predicted that the number of international students will continue to increase with the active growth in international exchange and due to diverse government support. This study introduces Padlet’s canvas layout in a class for international students to organize the course and boost engagement and interactions among the students and with the instructors. A survey and interviews with 22 undergraduate students from eight different countries, studying in Korea, were conducted to comprehend how they benefited from using the Padlet platform and their experience with it. The results indicate that Padlet enhances the students’ sense of belonging, expands their thinking processes through collaborative interactions and feedback from professors and colleagues, and increases their knowledge, leading to positive effects on class participation. Moreover, the use of Padlet accommodates diversity among different cultures and has a positive impact on cooperative learning in an international context. Based on these findings, several strategies for the implementation of Padlet in an educational setting can be suggested. To stimulate the participation of international students in learning, professors should consider offering the option of staying anonymous versus using real names when posting on Padlet. To improve the effectiveness of feedback, instructors should visualize their feedback. In addition, it is critical to institute guidelines to evaluate the relevance of the information in order to provide information that meets the students’ level of understanding and to establish a healthy level of information exchange. However, due to the limited sample size, the findings from this study cannot be generalized. Thus, we recommend expanding the sample in future studies to enable the use of inferential statistics, such as investigating differences in student attitudes by demographics. Full article

Electron and hole transporting layers play a major role in high-performance and stable organic-based optoelectronic devices. This paper demonstrates detailed device engineering of multi-junction organic photovoltaics built on two different metal oxide-based electron and hole transport (buffer) layers prepared by thermal or solution-processed methods. The main focus is on the device processing parameters as well as practical details of preparation of buffer layers to give the research community a clear, step-by-step recipe to successfully replicate and build series and parallel connected multi-junction solution-based organic solar cells for their needs. Here, the recipes and deposition conditions of two metal oxide buffer layers are presented in detail, based on basic commercially available materials and tools, to achieve well-engineered tandem (multi-junction) solution-processed organic solar cells. The buffer layers have appropriate energy levels for electrical selectivity of anode and cathode electrodes, and they are highly stable and chemically compatible with processing of solution-based polymer solar cells. To demonstrate the engineering steps of multi-junction devices, the PCE10:PC70BM blend is used as the active layer for all subcells. Then, to improve the power conversion efficiency of the single-junction photovoltaic device, PCE10:PC70BM blend is used in combination with DPPx:PC70BM with different absorption spectra for bottom and top subcell active layers. An optimized series tandem device with 10.6% power conversion efficiency is demonstrated. Generally, the device structures reported here can also be used for other types of optoelectronic devices, such as light emitting diodes and photodetectors. Full article

Self-assembled peptide-based nanobiomaterials exhibit promising prospects for drug delivery applications owing to their commendable biocompatibility and biodegradability, facile tissue uptake and utilization, and minimal or negligible unexpected toxicity. TFF3 is an active peptide autonomously secreted by gastric mucosal cells, possessing multiple biological functions. It acts on the surface of the gastric mucosa, facilitating the repair process of gastric mucosal damage. However, when used as a drug, TFF3 faces significant challenges, including short retention time in the gastric mucosal cavity and deactivation due to degradation by stomach acid. In response to this challenge, we developed a self-assembled short peptide hydrogel, Rqdl10, designed as a delivery vehicle for TFF3. Our investigation encompasses an assessment of its properties, biocompatibility, controlled release of TFF3, and the mechanism underlying the promotion of gastric mucosal injury repair. Congo red/aniline blue staining revealed that Rqdl10 promptly self-assembled in PBS, forming hydrogels. Circular dichroism spectra indicated the presence of a stable β-sheet secondary structure in the Rqdl10 hydrogel. Cryo-scanning electron microscopy and atomic force microscopy observations demonstrated that the Rqdl10 formed vesicle-like structures in the PBS, which were interconnected to construct a three-dimensional nanostructure. Moreover, the Rqdl10 hydrogel exhibited outstanding biocompatibility and could sustainably and slowly release TFF3. The utilization of the Rqdl10 hydrogel as a carrier for TFF3 substantially augmented its proliferative and migratory capabilities, while concurrently bolstering its anti-inflammatory and anti-apoptotic attributes following gastric mucosal injury. Our findings underscore the immense potential of the self-assembled peptide hydrogel Rqdl10 for biomedical applications, promising significant contributions to healthcare science. Full article

The feature of self-cleansing in sewer pipes is a standard requirement in the design of drainage systems, as sediments deposited on the channel bottom cause changes in channel geometric properties and in hydrodynamic parameters, including the friction caused by the cohesive forces of sediment fractions. Here, it is shown that the content of cohesive fractions significantly inhibits the transport of non-cohesive sediments. This paper presents an advanced calculation procedure for estimating flushing flows in channels. This procedure is based on innovative predictive models developed for non-cohesive and granulometrically heterogeneous sediment transport with additional cohesive fraction content to estimate the magnitude of increased flow necessary to ensure self-cleansing of channels. The computations according to the proposed procedure were carried out for a wide range of hydrodynamic conditions, two grain diameters, six cohesive (clay) fraction additive contents and two critical stress values. The trend lines of calculations were composed with the results of experimental studies in hydraulic flumes. Full article

This study aimed to understand the differences in the performance of diploid and tetraploid daylily cultivars under water deficit conditions, which are essential indicators of drought tolerance. This research revealed that tetraploid daylilies performed better than diploid varieties in arid conditions due to their enhanced adaptability and resilience to water deficit conditions. The analysis of the results highlighted the need to clarify the specific physiological and molecular mechanisms underlying the enhanced drought tolerance observed in tetraploid plants compared to diploids. This research offers valuable knowledge for improving crop resilience and sustainable floricultural practices in changing environmental conditions. The morphological and physiological parameters were analyzed in 19 diploid and 21 tetraploid daylily cultivars under controlled water deficit conditions, and three drought resistance groups were formed based on the clustering of these parameters. In a high drought resistance cluster, 93.3% tetraploid cultivars were exhibited. This study demonstrates the significance of ploidy in shaping plant responses to drought stress. It emphasizes the importance of studying plant responses to water deficit in landscape horticulture to develop drought-tolerant plants and ensure aspects of climate change. Full article

In the age of noticing the adverse effects of our activities on the climate, we pay more and more attention to designing sustainable solutions. Assumptions made during such sustainable designs often do not fulfil user needs. Therefore, we frequently encounter discrepancies, such as higher energy consumption and user modifications in the building systems compared to the design and use stages. To mitigate these problems in the lighting design context, the author describes the proposed lighting design method based on the Design Thinking methodology and concerns the commonly applied basic lighting design process. As an example design, an office room interior and lighting design are presented using the Design Thinking method described by the author. The utilised method allowed us to learn about problems that are only sometimes typical for offices and enter them into the design scope. The article contains a detailed analysis and comparison of normative requirements with users’ needs, collected from four room users and six guests. The discrepancies between the sustainable design and use stages presented in the article can be considered reduced, and users’ interference in the operation of devices will be eliminated due to meeting users’ needs and thus achieving sustainable goals. Full article

Facile access to some novel biologically relevant dihydrotriazolopyrimidine carboxylic acid-derived amide analogues using NMI/SO₂Cl₂, and aromatic and aliphatic primary and secondary amines, is reported herein. The role of N-methylimidazole (NMI) as the base and sulfuryl chloride (SO₂Cl₂) as the coupling reagent has been effectively realized in accessing these molecules in good to excellent yields. The feasibility of the developed protocol has also been extended to the gram-scale synthesis of N-benzylbenzamide in a 75% yield from benzoic acid and benzyl amine. The newly synthesized compounds were tested via in vitro anti-inflammatory and anti-tubercular activity studies. The compounds 6aa and 6be were found to be the most active anti-inflammatory agents, whereas 6cb and 6ch were found to exhibit promising anti-tubercular potency when compared to other synthesized molecules. The structure–activity relationship (SAR) studies revealed the importance of the presence of electron-donating functionalities in enhancing the anti-inflammatory potential of the newly synthesized molecules. However, the presence of electron-withdrawing substituents was found to be significant for improving their anti-tubercular potency. Full article

Chronic obstructive pulmonary disease (COPD) is a common condition with an estimated prevalence of 12% in adults over the age of 30 years worldwide. COPD is a leading cause of morbidity and mortality globally, with a substantial economic and social burden. There are an estimated 3 million deaths annually due to COPD. However, most of the patients with COPD respond to routine interventions like bronchodilator therapy, assessing supplemental oxygen needs, smoking cessation, vaccinations, and pulmonary rehabilitation. There is a significant number of patients who unfortunately progress to have persistent symptoms despite these interventions. Refractory COPD is not yet formally defined. Patients with severe persistent symptoms or exacerbations despite appropriate care can be considered to have refractory COPD. Managing refractory COPD needs a multidimensional approach. In this review article, we will discuss essential interventions like ensuring adequate inhaler techniques, exploring the need for non-invasive ventilatory support, use of chronic antibiotics and phosphodiesterase inhibitors to advanced therapies like bronchoscopic lung volume reduction surgery, and the upcoming role of anti-IL5 agents in managing patients with refractory COPD. We will also discuss non-pharmacologic interventions like psycho-social support and nutritional support. We will conclude by discussing the palliative care aspect of managing patients with refractory COPD. Through this review article, we aim to better the approach to managing patients with refractory COPD and discuss new upcoming therapies. Full article

In this study, the synergistic behavior of Ni and Al in two low-density steels (Fe-26Mn-10.2Al-0.98C-0.15V (wt. %) and Fe-29Mn-5Al-1C-12Ni (wt. %)) and their influence on microstructures and mechanical properties were investigated. The chemical composition of κ-carbides and B2 precipitated particles as a function of annealing and aging temperature and the matrix within which they formed were elucidated. The microstructures and deformation mechanisms of both steels were studied based on their strengthening contribution. The Fe-26Mn-10.2Al-0.98C-0.15V steel mainly realized precipitation strengthening through κ-carbides and grain boundary strengthening due to full recrystallization. The strengthening caused by Fe-29Mn-5Al-1C-12Ni steel was mainly due to the presence of the B2 phase in the matrix, which was non-coherent with FCC. This led to the Orowan bypass mechanism, which made precipitation strengthening the main strengthening contribution. The synergistic effect led to the shear or bypass mechanism of both steels when plane dislocation slip occurred. In addition, it also had an influence on the work-hardening capability during plastic deformation. This study provides a promising way to further enhance the yield strength of low-density austenitic steels through the synergistic effect of Ni and Al. Full article