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19 pages, 1794 KiB

Open AccessReview

Capacity to Consent in Healthcare: A Systematic Review and Meta-Analysis Comparing Patients with Bipolar Disorders and Schizophrenia Spectrum Disorders

by Donato Morena, Matteo Lippi, Nicola Di Fazio, Giuseppe Delogu, Raffaella Rinaldi, Paola Frati and Vittorio Fineschi

Medicina 2024, 60(5), 764; https://doi.org/10.3390/medicina60050764 (registering DOI) - 05 May 2024

Abstract

Background: Mental capacity is a fundamental aspect that enables patients to fully participate in various healthcare procedures. To assist healthcare professionals (HCPs) in assessing patients’ capacity, especially in the mental health field, several standardized tools have been developed. These tools include the [...] Read more.

Background: Mental capacity is a fundamental aspect that enables patients to fully participate in various healthcare procedures. To assist healthcare professionals (HCPs) in assessing patients’ capacity, especially in the mental health field, several standardized tools have been developed. These tools include the MacArthur Competence Assessment Tool for Treatment (MacCAT-T), the MacArthur Competence Assessment Tool for Clinical Research (MacCAT-CR), and the Competence Assessment Tool for Psychiatric Advance Directives (CAT-PAD). The core dimensions explored by these tools include Understanding, Appreciation, Reasoning, and Expression of a choice. Objective: This meta-analysis aimed to investigate potential differences in decision-making capacity within the healthcare context among groups of patients with bipolar disorders (BD) and schizophrenia spectrum disorders (SSD). Methods: A systematic search was conducted on Medline/Pubmed, and Scopus. Additionally, Google Scholar was manually inspected, and a manual search of emerging reviews and reference lists of the retrieved papers was performed. Eligible studies were specifically cross-sectional, utilizing standardized assessment tools, and involving patients diagnosed with BD and SSD. Data from the studies were independently extracted and pooled using random-effect models. Hedges’ g was used as a measure for outcomes. Results: Six studies were identified, with three studies using the MacCAT-CR, two studies the MacCAT-T, and one the CAT-PAD. The participants included 189 individuals with BD and 324 individuals with SSD. The meta-analysis revealed that patients with BD performed slightly better compared to patients with SSD, with the difference being statistically significant in the domain of Appreciation (ES = 0.23, 95% CI: 0.01 to 0.04, p = 0.037). There was no statistically significant difference between the two groups for Understanding (ES = 0.09, 95% CI:−0.10 to 0.27, p = 0.352), Reasoning (ES = 0.18, 95% CI: −0.12 to 0.47, p = 0.074), and Expression of a choice (ES = 0.23, 95% CI: −0.01 to 0.48, p = 0.60). In the sensitivity analysis, furthermore, when considering only studies involving patients in symptomatic remission, the difference for Appreciation also resulted in non-significant (ES = 0.21, 95% CI: −0.04 to 0.46, p = 0.102). Conclusions: These findings indicate that there are no significant differences between patients with BD and SSD during remission phases, while differences are minimal during acute phases. The usefulness of standardized assessment of capacity at any stage of the illness should be considered, both for diagnostic-therapeutic phases and for research and advance directives. Further studies are necessary to understand the reasons for the overlap in capacity between the two diagnostic categories compared in this study. Full article

(This article belongs to the Section Psychiatry)

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22 pages, 6481 KiB

Open AccessArticle

Development and Evaluation of a Water-Free In Situ Depot Gel Formulation for Long-Acting and Stable Delivery of Peptide Drug ACTY116

by Yingxin Xiong, Zhirui Liu, Yuanqiang Wang, Jiawei Wang, Xing Zhou and Xiaohui Li

Pharmaceutics 2024, 16(5), 620; https://doi.org/10.3390/pharmaceutics16050620 (registering DOI) - 05 May 2024

Abstract

In situ depot gel is a type of polymeric long-acting injectable (pLAI) drug delivery system; compared to microsphere technology, its preparation process is simpler and more conducive to industrialization. To ensure the chemical stability of peptide ACTY116, we avoided the use of harsh [...] Read more.

In situ depot gel is a type of polymeric long-acting injectable (pLAI) drug delivery system; compared to microsphere technology, its preparation process is simpler and more conducive to industrialization. To ensure the chemical stability of peptide ACTY116, we avoided the use of harsh conditions such as high temperatures, high shear mixing, or homogenization; maintaining a water-free and oxygen-free environment was also critical to prevent hydrolysis and oxidation. Molecular dynamics (MDs) simulations were employed to assess the stability mechanism between ACTY116 and the pLAI system. The initial structure of ACTY116 with an alpha helix conformation was constructed using SYBYL-X, and the copolymer PLGA was generated by AMBER 16; results showed that PLGA-based in situ depot gel improved conformational stability of ACTY116 through hydrogen bonds formed between peptide ACTY116 and the components of the pLAI formulation, while PLGA (Poly(DL-lactide-co-glycolide)) also created steric hindrance and shielding effects to prevent conformational changes. As a result, the chemical and conformational stability and in vivo long-acting characteristics of ACTY116 ensure its enhanced efficacy. In summary, we successfully achieved our objective of developing a highly stable peptide-loaded long-acting injectable (LAI) in situ depot gel formulation that is stable for at least 3 months under harsh conditions (40 °C, above body temperature), elucidating the underlying stabilisation mechanism, and the high stability of the ACTY116 pLAI formulation creates favourable conditions for its in vivo pharmacological activity lasting for weeks or even months. Full article

(This article belongs to the Special Issue Recent Advances in Polymeric Delivery Vehicles for Controlled and Sustained Drug Release)

18 pages, 43969 KiB

Open AccessArticle

Improvement in the Accuracy and Efficiency of Smoothed Particle Hydrodynamics: Point Generation and Adaptive Particle Refinement/Coarsening Algorithms

by Jun Zhang, Yanchao Ding, Wei Wu, Wenjie Li, Zhaoming Zhang and Yanmei Jiao

Actuators 2024, 13(5), 174; https://doi.org/10.3390/act13050174 (registering DOI) - 05 May 2024

Abstract

An adaptive particle refinement (APR) algorithm has been developed for the smoothed particle hydrodynamics (SPH) method to augment the resolution of the region of interest to achieve high accuracy and simultaneously reduce the cost of computational resources. It is widely applied in the [...] Read more.

An adaptive particle refinement (APR) algorithm has been developed for the smoothed particle hydrodynamics (SPH) method to augment the resolution of the region of interest to achieve high accuracy and simultaneously reduce the cost of computational resources. It is widely applied in the field of fluid-controlling problems involving large interface deformations, such as the two-phase flow and fluid–structure interaction because this algorithm can capture the interface with high accuracy. Nonetheless, existing APR algorithms widely encounter computational dispersion issues at the interface of regions of different particle resolutions. Moreover, traditional shifting algorithms applied in the APR processes also have difficulties in dealing with particles with different smooth lengths. In this work, an algorithm for fast particle generation was first developed based on the accelerated ray method, which accelerates the discretization of the flow field into particles. Then, a dynamic refinement/coarsening algorithm based on the APR algorithm is proposed to solve the computational dispersion problem that occurs at the refinement/coarsening interfaces. In addition, the shifting algorithm was improved in this work to ensure the particles are always well distributed during numerical calculations and, thus, can efficiently facilitate the adaptive particle refinement/coarsening processes. Comparative analysis indicates that the robust algorithms developed for the SPH method in this work can lead to more precise and reasonable flow fields compared with the conventional SPH adaptive methods. Full article

(This article belongs to the Special Issue Active Flow Control: Recent Advances in Fundamentals and Applications — Volume II)

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14 pages, 4586 KiB

Open AccessArticle

Delivery of Mesenchymal Stem Cells during Hypothermic Machine Perfusion in a Translational Kidney Perfusion Study

by Natalie Vallant, Nienke Wolfhagen, Bynvant Sandhu, Karim Hamaoui and Vassilios Papalois

Int. J. Mol. Sci. 2024, 25(9), 5038; https://doi.org/10.3390/ijms25095038 (registering DOI) - 05 May 2024

Abstract

In transplantation, hypothermic machine perfusion (HMP) has been shown to be superior to static cold storage (SCS) in terms of functional outcomes. Ex vivo machine perfusion offers the possibility to deliver drugs or other active substances, such as Mesenchymal Stem Cells (MSCs), directly [...] Read more.

In transplantation, hypothermic machine perfusion (HMP) has been shown to be superior to static cold storage (SCS) in terms of functional outcomes. Ex vivo machine perfusion offers the possibility to deliver drugs or other active substances, such as Mesenchymal Stem Cells (MSCs), directly into an organ without affecting the recipient. MSCs are multipotent, self-renewing cells with tissue-repair capacities, and their application to ameliorate ischemia- reperfusion injury (IRI) is being investigated in several preclinical and clinical studies. The aim of this study was to introduce MSCs into a translational model of hypothermic machine perfusion and to test the efficiency and feasibility of this method. Methods: three rodent kidneys, six porcine kidneys and three human kidneys underwent HMP with 1–5 × 10⁶ labelled MSCs within respective perfusates. Only porcine kidneys were compared to a control group of 6 kidneys undergoing HMP without MSCs, followed by mimicked reperfusion with whole blood at 37 °C for 2 h for all 12 kidneys. Reperfusion perfusate samples were analyzed for levels of NGAL and IL-β by ELISA. Functional parameters, including urinary output, oxygen consumption and creatinine clearance, were compared and found to be similar between the MSC treatment group and the control group in the porcine model. IL-1β levels were higher in perfusate and urine samples in the MSC group, with a median of 285.3 ng/mL (IQR 224.3–407.8 ng/mL) vs. 209.2 ng/mL (IQR 174.9–220.1), p = 0.51 and 105.3 ng/mL (IQR 71.03–164.7 ng/mL) vs. 307.7 ng/mL (IQR 190.9–349.6 ng/mL), p = 0.16, respectively. MSCs could be traced within the kidneys in all models using widefield microscopy after HMP. The application of Mesenchymal Stem Cells in an ex vivo hypothermic machine perfusion setting is feasible, and MSCs can be delivered into the kidney grafts during HMP. Functional parameters during mimicked reperfusion were not altered in treated kidney grafts. Changes in levels of IL-1β suggest that MSCs might have an effect on the kidney grafts, and whether this leads to a positive or a negative outcome on IRI in transplantation needs to be determined in further experiments. Full article

(This article belongs to the Special Issue Unraveling the Molecular Mechanisms of Mesenchymal Stem Cells Protective Action 2.0)

31 pages, 28461 KiB

Open AccessArticle

Study on the Impact of Design Factors of Piloti Forms on the Thermal Environment in Residential Quarters

by Jinhan Li, Xiaofang Shan and Qinli Deng

Buildings 2024, 14(5), 1303; https://doi.org/10.3390/buildings14051303 (registering DOI) - 05 May 2024

Abstract

According to piloti design, the outdoor thermal environment can be improved in cities with hot summer conditions. Taking Chinese cities with a hot summer and cold winter as the research object, this paper discusses the improvement of the outdoor thermal environment of residential [...] Read more.

According to piloti design, the outdoor thermal environment can be improved in cities with hot summer conditions. Taking Chinese cities with a hot summer and cold winter as the research object, this paper discusses the improvement of the outdoor thermal environment of residential districts in summer by considering piloti design factors. In this article, according to our investigation of piloti design in Wuhan, a basic model of the overhead layer in the Wuhan residential area is presented, along with the effects of different piloti ratios (0–80%), piloti heights (2–6 m), and greening rates (30–35%) on the outdoor thermal environment of buildings. The average air temperature and average wind speed at the pedestrian level are used as outdoor thermal environment indicators, the average PET is used as the outdoor thermal comfort indicator, and the comfort wind ratio is used as the outdoor wind comfort indicator. The results show that increasing the ratio of corridor columns has the greatest thermal comfort enhancement effect in the corridor area, and when the piloti ratio increases from 20% to 80%, the PET in piloti areas reduces by 2.926 °C. Improving the greening rate has the greatest thermal comfort enhancement effect in the passageway area, and when the greening rate increases from 20% to 80%, the PET in piloti areas reduces by 0.9 °C. Furthermore, the increases in both the piloti ratio and piloti height have an enhancement effect on the outdoor wind environment and wind comfort, with thresholds of a piloti ratio over 60% and a piloti height over 5 m. In contrast, the increase in the greening rate will deteriorate the outdoor wind environment and wind comfort. The conclusions of this study are of great significance for the planning and design of overhead layers in residential areas in hot and humid areas in summer. Full article

(This article belongs to the Special Issue Building Energy-Saving Technology—2nd Edition)

22 pages, 10465 KiB

Open AccessArticle

Inhibition of NF-κB with an Analog of Withaferin-A Restores TDP-43 Homeostasis and Proteome Profiles in a Model of Sporadic ALS

by Pooja Shree Mishra, Daniel Phaneuf, Hejer Boutej, Vincent Picher-Martel, Nicolas Dupre, Jasna Kriz and Jean-Pierre Julien

Biomedicines 2024, 12(5), 1017; https://doi.org/10.3390/biomedicines12051017 (registering DOI) - 05 May 2024

Abstract

The current knowledge on pathogenic mechanisms in amyotrophic lateral sclerosis (ALS) has widely been derived from studies with cell and animal models bearing ALS-linked genetic mutations. However, it remains unclear to what extent these disease models are of relevance to sporadic ALS. Few [...] Read more.

The current knowledge on pathogenic mechanisms in amyotrophic lateral sclerosis (ALS) has widely been derived from studies with cell and animal models bearing ALS-linked genetic mutations. However, it remains unclear to what extent these disease models are of relevance to sporadic ALS. Few years ago, we reported that the cerebrospinal fluid (CSF) from sporadic ALS patients contains toxic factors for disease transmission in mice via chronic intracerebroventricular (i.c.v.) infusion. Thus a 14-day i.c.v. infusion of pooled CSF samples from ALS cases in mice provoked motor impairment as well as ALS-like pathological features. This offers a unique paradigm to test therapeutics in the context of sporadic ALS disease. Here, we tested a new Withaferin-A analog (IMS-088) inhibitor of NF-κB that was found recently to mitigate disease phenotypes in mouse models of familial disease expressing TDP-43 mutant. Our results show that oral intake of IMS-088 ameliorated motor performance of mice infused with ALS-CSF and it alleviated pathological changes including TDP-43 proteinopathy, neurofilament disorganization, and neuroinflammation. Moreover, CSF infusion experiments were carried out with transgenic mice having neuronal expression of tagged ribosomal protein (hNfL-RFP mice), which allowed immunoprecipitation of neuronal ribosomes for analysis by mass spectrometry of the translational peptide signatures. The results indicate that treatment with IMS-088 prevented many proteomic alterations associated with exposure to ALS-CSF involving pathways related to cytoskeletal changes, inflammation, metabolic dysfunction, mitochondria, UPS, and autophagy dysfunction. The effective disease-modifying effects of this drug in a mouse model based on i.c.v. infusion of ALS-CSF suggest that the NF-κB signaling pathway represents a compelling therapeutic target for sporadic ALS. Full article

(This article belongs to the Special Issue New Insights into Motor Neuron Diseases)

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18 pages, 1945 KiB

Open AccessArticle

Antimicrobial Activity of Fungal Endophytes Associated with Peperomia argyreia (Piperaceae)

by Melisa Isabel Barolo, María Victoria Castelli and Silvia Noelí López

Appl. Microbiol. 2024, 4(2), 753-770; https://doi.org/10.3390/applmicrobiol4020052 (registering DOI) - 05 May 2024

Abstract

The endophytic fungal biodiversity of unique plants like Peperomia argyreia (Miq.) É. Morren (Piperaceae) has antimicrobial properties and can be employed for infection treatment. Fungal isolates were obtained from appropriately treated plant tissues cultured in solid media, characterized by morphology, and identified by [...] Read more.

The endophytic fungal biodiversity of unique plants like Peperomia argyreia (Miq.) É. Morren (Piperaceae) has antimicrobial properties and can be employed for infection treatment. Fungal isolates were obtained from appropriately treated plant tissues cultured in solid media, characterized by morphology, and identified by molecular biology using ITS and NL primers. The antimicrobial properties of fungal extracts were analyzed by combining microdilution and bioautographic assays complemented with metabolic profiling by automated thin-layer chromatography and ¹H NMR techniques. Thirty-one filamentous fungi were isolated and characterized by ITS and/or D1/D2 region amplification of rDNA, identified as Thermothielavioides, Trichoderma, Cyphellophora, Cladosporium, Arcopilus, Plectosphaerella; Chaetomium, Sporothrix, Alboefibula, and Penicillium. Thermothielavioides spp. inhibited Staphylococcus aureus ATCC 25923; moreover, Penicillium westlingii P4 showed inhibitory activity on Ascochyta rabiei AR2. The bioactivity-guided fractionation of the EtOAc extract (MIC = 62.5 μg/mL) of P. westlingii P4 allowed the purification of citrinin as the main inhibitory compound (MIC = 62.5 μg/mL). Peperomia argyreia harbors a rich and diverse endophytic community able to produce bioactive molecules. Citrinin, with a minor influence of volatile compounds biosynthesized by P. westlingii P4, was responsible for the inhibition of A. rabiei AR2. Full article

16 pages, 1465 KiB

Open AccessArticle

Influence of Casting Variables on Release Kinetics of Orally Disintegrating Film

by Jang-Ho Shin and Jung-Ah Han

Foods 2024, 13(9), 1418; https://doi.org/10.3390/foods13091418 (registering DOI) - 05 May 2024

Abstract

As a new form for supplying vitamin C, orally disintegrating films (ODFs) were developed C based on hyaluronic acid (HA) under varying casting conditions and the properties were analyzed. The films with different thicknesses (2, 3, and 8 mm, for CT2, CT4, and [...] Read more.

As a new form for supplying vitamin C, orally disintegrating films (ODFs) were developed C based on hyaluronic acid (HA) under varying casting conditions and the properties were analyzed. The films with different thicknesses (2, 3, and 8 mm, for CT2, CT4, and CT8, respectively) were produced by adjustments made to casting height. Two types of 8 mm thick ODFs produced by single or double casting (4 + 4 mm for CTD4+4) methods were also compared. As film thickness increased, water vapor permeability and tensile strength also increased. Even at equal thickness, manufacturing with double casting exhibited a stronger texture and reduced disintegration compared to single casting. All ODFs met the World Health Organization’s recommended daily vitamin C intake (45 mg/day) with a single sheet. Films showed over 80% dissolution in various solvents, adhering to the Hixson–Crowell cube root law, indicating vitamin C release occurred via porous penetration of the eluate. For CT2, CT4, and CTD4+4, vitamin C release was primarily governed by diffusion within the gel matrix and HA erosion. However, for CT8, HA erosion-induced release somewhat dominated. Based on the sensory test, it seems desirable to adjust the thickness of the film to 2 or 4 mm, because a thickness greater than that increased the foreign body sensation due to prolonged residence in the oral cavity. Full article

(This article belongs to the Section Food Engineering and Technology)

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21 pages, 1276 KiB

Open AccessReview

Adult Female Acne: Recent Advances in Pathophysiology and Therapeutic Approaches

by Andreea Amuzescu, Mircea Tampa, Clara Matei and Simona Roxana Georgescu

Cosmetics 2024, 11(3), 74; https://doi.org/10.3390/cosmetics11030074 (registering DOI) - 05 May 2024

Abstract

Adult acne is a chronic inflammatory disease of the pilosebaceous unit characterized by the excessive production of abnormal sebum favoring an imbalance of the skin microbiota and the hyperproliferation of Cutibacterium acnes and other virulent microbial strains, leading to an inflammatory environment, innate [...] Read more.

Adult acne is a chronic inflammatory disease of the pilosebaceous unit characterized by the excessive production of abnormal sebum favoring an imbalance of the skin microbiota and the hyperproliferation of Cutibacterium acnes and other virulent microbial strains, leading to an inflammatory environment, innate immunity overactivation, and keratinocyte hyperproliferation in hair follicles pores. Degraded keratinocytes plug the pores, consequently forming microcomedons, which can later evolve to papules, nodules, pustules and scars. Distinct from juvenile acne, in adult female acne (AFA) the symptomatology occurs or persists in postadolescence (after age 25). Although hyperandrogenism or the excessive sensitivity of androgen receptors are the main causes, AFA can be triggered by multiple factors, either including or not including androgen disturbances. The prevalence in adult women is 15–20%. Hyperandrogenism is present in 50% of cases; 70% of hyperandrogenism cases feature polycystic ovary syndrome (PCOS), a complex endocrine and metabolic condition. Genetic susceptibility occurs in 80% of acne cases, often with familial inheritance. Beyond classical stepwise therapeutic protocols (topical agents, isotretinoin, antibiotics, hormonal therapy with estrogens, progestins, spironolactone), novel approaches include the highly effective topical antiandrogen clascoterone, the management of insulin resistance by diet, exercise, stress avoidance, and adjuvant therapies such as berberine. Vaccines against the pathogenic proinflammatory C. acnes hyaluronidase A are in development. Full article

(This article belongs to the Special Issue Current and Future Trends in Cosmetics Research: The 10th Anniversary of Cosmetics)

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27 pages, 1187 KiB

Open AccessArticle

Transforming Cybersecurity into Critical Energy Infrastructure: A Study on the Effectiveness of Artificial Intelligence

by Jaime Govea, Walter Gaibor-Naranjo and William Villegas-Ch

Systems 2024, 12(5), 165; https://doi.org/10.3390/systems12050165 (registering DOI) - 05 May 2024

Abstract

This work explores the integration and effectiveness of artificial intelligence in improving the security of critical energy infrastructure, highlighting its potential to transform cybersecurity practices in the sector. The ability of artificial intelligence solutions to detect and respond to cyber threats in critical [...] Read more.

This work explores the integration and effectiveness of artificial intelligence in improving the security of critical energy infrastructure, highlighting its potential to transform cybersecurity practices in the sector. The ability of artificial intelligence solutions to detect and respond to cyber threats in critical energy infrastructure environments was evaluated through a methodology that combines empirical analysis and artificial intelligence modeling. The results indicate a significant increase in the threat detection rate, reaching 98%, and a reduction in incident response time by more than 70%, demonstrating the effectiveness of artificial intelligence in identifying and mitigating cyber risks quickly and accurately. In addition, implementing machine learning algorithms has allowed for the early prediction of failures and cyber-attacks, significantly improving proactivity and security management in energy infrastructure. This study highlights the importance of integrating artificial intelligence into energy infrastructure security strategies, proposing a paradigmatic change in cybersecurity management that increases operational efficiency and strengthens the resilience and sustainability of the energy sector against cyber threats. Full article

(This article belongs to the Special Issue Cyber Security Challenges in Complex Systems)

20 pages, 4839 KiB

Open AccessArticle

Identification of Novel Regulators of Leaf Senescence Using a Deep Learning Model

by Chaocheng Guo, Zhuoran Huang, Jiahao Chen, Guolong Yu, Yudong Wang and Xu Wang

Plants 2024, 13(9), 1276; https://doi.org/10.3390/plants13091276 (registering DOI) - 05 May 2024

Abstract

Deep learning has emerged as a powerful tool for investigating intricate biological processes in plants by harnessing the potential of large-scale data. Gene regulation is a complex process that transcription factors (TFs), cooperating with their target genes, participate in through various aspects of [...] Read more.

Deep learning has emerged as a powerful tool for investigating intricate biological processes in plants by harnessing the potential of large-scale data. Gene regulation is a complex process that transcription factors (TFs), cooperating with their target genes, participate in through various aspects of biological processes. Despite its significance, the study of gene regulation has primarily focused on a limited number of notable instances, leaving numerous aspects and interactions yet to be explored comprehensively. Here, we developed DEGRN (Deep learning on Expression for Gene Regulatory Network), an innovative deep learning model designed to decipher gene interactions by leveraging high-dimensional expression data obtained from bulk RNA-Seq and scRNA-Seq data in the model plant Arabidopsis. DEGRN exhibited a compared level of predictive power when applied to various datasets. Through the utilization of DEGRN, we successfully identified an extensive set of 3,053,363 high-quality interactions, encompassing 1430 TFs and 13,739 non-TF genes. Notably, DEGRN’s predictive capabilities allowed us to uncover novel regulators involved in a range of complex biological processes, including development, metabolism, and stress responses. Using leaf senescence as an example, we revealed a complex network underpinning this process composed of diverse TF families, including bHLH, ERF, and MYB. We also identified a novel TF, named MAF5, whose expression showed a strong linear regression relation during the progression of senescence. The mutant maf5 showed early leaf decay compared to the wild type, indicating a potential role in the regulation of leaf senescence. This hypothesis was further supported by the expression patterns observed across four stages of leaf development, as well as transcriptomics analysis. Overall, the comprehensive coverage provided by DEGRN expands our understanding of gene regulatory networks and paves the way for further investigations into their functional implications. Full article

(This article belongs to the Section Plant Genetics, Genomics and Biotechnology)

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15 pages, 1190 KiB

Open AccessArticle

A Study of the Feasibility of Pinus patula Biochar: The Regeneration of the Indigo Carmine-Loaded Biochar and its Efficiency for Real Textile Wastewater Treatment

by Carolina Gallego-Ramírez, Edwin Chica and Ainhoa Rubio-Clemente

Processes 2024, 12(5), 939; https://doi.org/10.3390/pr12050939 (registering DOI) - 05 May 2024

Abstract

The feasibility of an adsorbent material like biochar (BC) depends on its regeneration capacity and its ability to achieve high removal efficiencies on real wastewater (WW) effluents. In this study, the regeneration capacity of the Pinus patula BC previously used in the removal [...] Read more.

The feasibility of an adsorbent material like biochar (BC) depends on its regeneration capacity and its ability to achieve high removal efficiencies on real wastewater (WW) effluents. In this study, the regeneration capacity of the Pinus patula BC previously used in the removal of Indigo Carmine from water was evaluated. The regeneration technique that resulted in the highest desorption efficiency was a thermo-chemical method that consisted of heating the spent BC in a stove at 160 °C for 45 min followed by regeneration with ethanol (C₂H₆O) at a concentration of 75% for 6 h. Through this regeneration method, it was found that Pinus patula BC could be used in seven consecutive adsorption–desorption cycles. The feasibility of this BC was also assessed by evaluating the adsorbent’s efficiency in real textile WW. Under optimal operational conditions (solution pH = 3, BC dose = 13.5 g/L, and BC particle size = 300–450 µm), the highest removal efficiencies in terms of colour and dissolved organic carbon (DOC) were 81.3 and 76.8%, respectively, for 120 min of treatment. The results obtained in the regeneration studies and the treatment of real textile WW suggested that the use of Pinus patula BC could be suitable to be scaled to an industrial level, contributing to sustainable development and the circular bioeconomy by using a waste to solve the dye pollution problem of another waste. Full article

(This article belongs to the Special Issue A Themed Issue in Honor of Professor Vicente Gómez Serrano: Innovation in Production, Characterization and Applications of Activated Carbon, Biochar and Other Carbon-Based Materials)

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18 pages, 5015 KiB

Open AccessArticle

Na₃MnTi(PO₄)₃/C Nanofiber Free-Standing Electrode for Long-Cycling-Life Sodium-Ion Batteries

by Debora Maria Conti, Claudia Urru, Giovanna Bruni, Pietro Galinetto, Benedetta Albini, Vittorio Berbenni, Alessandro Girella and Doretta Capsoni

Nanomaterials 2024, 14(9), 804; https://doi.org/10.3390/nano14090804 (registering DOI) - 05 May 2024

Abstract

Self-standing Na₃MnTi(PO₄)₃/carbon nanofiber (CNF) electrodes are successfully synthesized by electrospinning. A pre-synthesized Na₃MnTi(PO₄)₃ is dispersed in a polymeric solution, and the electrospun product is heat-treated at 750 °C in nitrogen flow to [...] Read more.

Self-standing Na₃MnTi(PO₄)₃/carbon nanofiber (CNF) electrodes are successfully synthesized by electrospinning. A pre-synthesized Na₃MnTi(PO₄)₃ is dispersed in a polymeric solution, and the electrospun product is heat-treated at 750 °C in nitrogen flow to obtain active material/CNF electrodes. The active material loading is 10 wt%. SEM, TEM, and EDS analyses demonstrate that the Na₃MnTi(PO₄)₃ particles are homogeneously spread into and within CNFs. The loaded Na₃MnTi(PO₄)₃ displays the NASICON structure; compared to the pre-synthesized material, the higher sintering temperature (750 °C) used to obtain conductive CNFs leads to cell shrinkage along the a axis. The electrochemical performances are appealing compared to a tape-casted electrode appositely prepared. The self-standing electrode displays an initial discharge capacity of 124.38 mAh/g at 0.05C, completely recovered after cycling at an increasing C-rate and a coulombic efficiency ≥98%. The capacity value at 20C is 77.60 mAh/g, and the self-standing electrode exhibits good cycling performance and a capacity retention of 59.6% after 1000 cycles at 1C. Specific capacities of 33.6, 22.6, and 17.3 mAh/g are obtained by further cycling at 5C, 10C, and 20C, and the initial capacity is completely recovered after 1350 cycles. The promising capacity values and cycling performance are due to the easy electrolyte diffusion and contact with the active material, offered by the porous nature of non-woven nanofibers. Full article

(This article belongs to the Special Issue Advances in Nanostructured Electrode Materials: Design and Applications)

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10 pages, 3607 KiB

Open AccessArticle

High Resolution Crystal Structure of the Pyruvate Kinase Tetramer in Complex with the Allosteric Activator Mitapivat/AG-348

by Xiao Han, Tatyana Sandalova, Cheng Zhang, Adil Mardinoglu, Adnane Achour and Renhua Sun

Crystals 2024, 14(5), 441; https://doi.org/10.3390/cryst14050441 (registering DOI) - 05 May 2024

Abstract

Pyruvate kinase (PK) deficiency is a rare genetic disorder that affects this critical enzyme within the glycolysis pathway. In recent years, Mitapivat (MTPV, AG-348) has emerged as a notable allosteric activator for treating PK deficiency. However, the allosteric regulatory effects exerted on PK [...] Read more.

Pyruvate kinase (PK) deficiency is a rare genetic disorder that affects this critical enzyme within the glycolysis pathway. In recent years, Mitapivat (MTPV, AG-348) has emerged as a notable allosteric activator for treating PK deficiency. However, the allosteric regulatory effects exerted on PK by MTPV are yet to be comprehensively elucidated. To shed light on the molecular mechanisms of the allosteric effects, we employed crystallography and biophysical methods. Our efforts yielded a high-resolution crystal structure of the PK tetramer complexed with MTPV at 2.1 Å resolution. Isothermal titration calorimetry measurements revealed that MTPV binds to human PK with an affinity of 1 μM. The enhanced structural details now allow for unambiguous analysis of the MTPV-filled cavity intricately embedded within the enzyme. Finally, the structure suggests that MTPV binding induces an allosteric effect on the B-domain situated proximal to the active site. In summary, our study provides valuable insights into the allosteric regulation of PK by MTPV and paves the way for further structure-based drug optimization for therapeutic interventions in PK deficiency. Full article

(This article belongs to the Special Issue X-ray Crystallography and Drug Discovery)

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23 pages, 8208 KiB

Open AccessReview

Smart Sensing Chairs for Sitting Posture Detection, Classification, and Monitoring: A Comprehensive Review

by David Faith Odesola, Janusz Kulon, Shiny Verghese, Adam Partlow and Colin Gibson

Sensors 2024, 24(9), 2940; https://doi.org/10.3390/s24092940 (registering DOI) - 05 May 2024

Abstract

Incorrect sitting posture, characterized by asymmetrical or uneven positioning of the body, often leads to spinal misalignment and muscle tone imbalance. The prolonged maintenance of such postures can adversely impact well-being and contribute to the development of spinal deformities and musculoskeletal disorders. In [...] Read more.

Incorrect sitting posture, characterized by asymmetrical or uneven positioning of the body, often leads to spinal misalignment and muscle tone imbalance. The prolonged maintenance of such postures can adversely impact well-being and contribute to the development of spinal deformities and musculoskeletal disorders. In response, smart sensing chairs equipped with cutting-edge sensor technologies have been introduced as a viable solution for the real-time detection, classification, and monitoring of sitting postures, aiming to mitigate the risk of musculoskeletal disorders and promote overall health. This comprehensive literature review evaluates the current body of research on smart sensing chairs, with a specific focus on the strategies used for posture detection and classification and the effectiveness of different sensor technologies. A meticulous search across MDPI, IEEE, Google Scholar, Scopus, and PubMed databases yielded 39 pertinent studies that utilized non-invasive methods for posture monitoring. The analysis revealed that Force Sensing Resistors (FSRs) are the predominant sensors utilized for posture detection, whereas Convolutional Neural Networks (CNNs) and Artificial Neural Networks (ANNs) are the leading machine learning models for posture classification. However, it was observed that CNNs and ANNs do not outperform traditional statistical models in terms of classification accuracy due to the constrained size and lack of diversity within training datasets. These datasets often fail to comprehensively represent the array of human body shapes and musculoskeletal configurations. Moreover, this review identifies a significant gap in the evaluation of user feedback mechanisms, essential for alerting users to their sitting posture and facilitating corrective adjustments. Full article

(This article belongs to the Special Issue Advanced Non-invasive Sensors: Methods and Applications)

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13 pages, 507 KiB

Open AccessReview

Revolutionizing Localized Lung Cancer Treatment: Neoadjuvant Chemotherapy plus Immunotherapy for All?

by Victoria Ferrari and Carole Helissey

J. Clin. Med. 2024, 13(9), 2715; https://doi.org/10.3390/jcm13092715 (registering DOI) - 05 May 2024

Abstract

Lung cancer poses a significant public health challenge, with resectable non-small cell lung cancer (NSCLC) representing 20 to 25% of all NSCLC cases, staged between I and IIIA. Despite surgical interventions, patient survival remains unsatisfactory, with approximately 50% mortality within 5 years across [...] Read more.

Lung cancer poses a significant public health challenge, with resectable non-small cell lung cancer (NSCLC) representing 20 to 25% of all NSCLC cases, staged between I and IIIA. Despite surgical interventions, patient survival remains unsatisfactory, with approximately 50% mortality within 5 years across early stages. While perioperative chemotherapy offers some benefit, outcomes vary. Therefore, novel therapeutic approaches are imperative to improve patient survival. The combination of chemotherapy and immunotherapy emerges as a promising avenue. In this review, we explore studies demonstrating the benefits of this combination therapy, its impact on surgical procedures, and patient quality of life. However, challenges persist, particularly for patients failing to achieve pathologic complete response (pCR), those with stage II lung cancer, and individuals with specific genetic mutations. Additionally, identifying predictive biomarkers remains challenging. Nevertheless, the integration of immunotherapy and chemotherapy in the preoperative setting presents a new paradigm in managing resectable lung cancer, heralding more effective and personalized treatments for patients. Full article

(This article belongs to the Special Issue Review Special Issue Series: Neoadjuvant Lung Cancer Surgery)

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18 pages, 660 KiB

Open AccessArticle

Cyclometalated and NNN Terpyridine Ruthenium Photocatalysts and Their Cytotoxic Activity

by Maurizio Ballico, Dario Alessi, Eleonora Aneggi, Marta Busato, Daniele Zuccaccia, Lorenzo Allegri, Giuseppe Damante, Christian Jandl and Walter Baratta

Molecules 2024, 29(9), 2146; https://doi.org/10.3390/molecules29092146 (registering DOI) - 05 May 2024

Abstract

The cyclometalated terpyridine complexes [Ru(η²-OAc)(NC-tpy)(PP)] (PP = dppb 1, (R,R)-Skewphos 4, (S,S)-Skewphos 5) are easily obtained from the acetate derivatives [Ru(η²-OAc)₂(PP)] (PP = dppb, (R [...] Read more.

The cyclometalated terpyridine complexes [Ru(η²-OAc)(NC-tpy)(PP)] (PP = dppb 1, (R,R)-Skewphos 4, (S,S)-Skewphos 5) are easily obtained from the acetate derivatives [Ru(η²-OAc)₂(PP)] (PP = dppb, (R,R)-Skewphos 2, (S,S)-Skewphos 3) and tpy in methanol by elimination of AcOH. The precursors 2, 3 are prepared from [Ru(η²-OAc)₂(PPh₃)₂] and Skewphos in cyclohexane. Conversely, the NNN complexes [Ru(η¹-OAc)(NNN-tpy)(PP)]OAc (PP = (R,R)-Skewphos 6, (S,S)-Skewphos 7) are synthesized in a one pot reaction from [Ru(η²-OAc)₂(PPh₃)₂], PP and tpy in methanol. The neutral NC-tpy 1, 4, 5 and cationic NNN-tpy 6, 7 complexes catalyze the transfer hydrogenation of acetophenone (S/C = 1000) in 2-propanol with NaOiPr under light irradiation at 30 °C. Formation of (S)-1-phenylethanol has been observed with 4, 6 in a MeOH/iPrOH mixture, whereas the R-enantiomer is obtained with 5, 7 (50–52% ee). The tpy complexes show cytotoxic activity against the anaplastic thyroid cancer 8505C and SW1736 cell lines (ED₅₀ = 0.31–8.53 µM), with the cationic 7 displaying an ED₅₀of 0.31 µM, four times lower compared to the enantiomer 6. Full article

(This article belongs to the Special Issue Feature Papers in Photochemistry and Photocatalysis)

14 pages, 2181 KiB

Open AccessArticle

Bond Strength of Milled and Printed Zirconia to 10-Methacryloyloxydecyl Dihydrogen Phosphate (10-MDP) Resin Cement as a Function of Ceramic Conditioning, Disinfection and Ageing

by Wolfgang Bömicke, Franz Sebastian Schwindling, Peter Rammelsberg and Stefan Rues

Materials 2024, 17(9), 2159; https://doi.org/10.3390/ma17092159 (registering DOI) - 05 May 2024

Abstract

This study aimed to assess the suitability of printed zirconia (ZrO₂) for adhesive cementation compared to milled ZrO₂. Surface conditioning protocols and disinfection effects on bond strength were also investigated. ZrO₂ discs (n = 14/group) underwent either alumina [...] Read more.

This study aimed to assess the suitability of printed zirconia (ZrO₂) for adhesive cementation compared to milled ZrO₂. Surface conditioning protocols and disinfection effects on bond strength were also investigated. ZrO₂ discs (n = 14/group) underwent either alumina (Al₂O₃) airborne particle abrasion (APA; 50 µm, 0.10 MPa) or tribochemical silicatisation (TSC; 110 µm Al₂O₃, 0.28 MPa and 110 µm silica-modified Al₂O₃, 0.28 MPa), followed by disinfection (1 min immersion in 70% isopropanol, 15 s water spray, 10 s drying with oil-free air) for half of the discs. A resin cement containing 10-methacryloyloxydecyl dihydrogen phosphate (10-MDP) was used for bonding (for TSC specimens after application of a primer containing silane and 10-MDP). Tensile bond strength was measured after storage for 24 h at 100% relative humidity or after 30 days in water, including 7500 thermocycles. Surface conditioning significantly affected bond strength, with higher values for TSC specimens. Ageing and the interaction of conditioning, disinfection and ageing also impacted bond strength. Disinfection combined with APA mitigated ageing-related bond strength decrease but exacerbated it for TSC specimens. Despite these effects, high bond strengths were maintained even after disinfection and ageing. Adhesive cementation of printed ZrO₂ restorations exhibited comparable bond strengths to milled ZrO₂, highlighting its feasibility in clinical applications. Full article

(This article belongs to the Special Issue Advanced Dental Materials: From Design to Application)

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15 pages, 3578 KiB

Open AccessArticle

Nitric Acid Rain Decreases Soil Bacterial Diversity and Alters Bacterial Community Structure in Farmland Soils

by Xuan Chen, Yiming Wang, Hui Wei and Jiaen Zhang

Agronomy 2024, 14(5), 971; https://doi.org/10.3390/agronomy14050971 (registering DOI) - 05 May 2024

Abstract

Being regarded as one of the environmental problems endangering biodiversity and ecosystem health, acid rain has attracted wide attention. Here, we studied the effects of nitric acid rain (NAR) on the structure and diversity of microbial communities in agricultural soils by laboratory incubation [...] Read more.

Being regarded as one of the environmental problems endangering biodiversity and ecosystem health, acid rain has attracted wide attention. Here, we studied the effects of nitric acid rain (NAR) on the structure and diversity of microbial communities in agricultural soils by laboratory incubation experiments and greenhouse experiments. Our results indicated that NAR had an inhibitory effect on soil microorganisms, showing a significant reduction in the Chao1 index and Shannon index of soil bacteria. Proteobacteria, Acidobacteriota, Actinobacteriota, and Chloroflexi were the dominant bacterial phyla under NAR stress in this study. NAR significantly reduced the relative abundance of Proteobacteria and Actinobacteria, but significantly increased the relative abundance of Acidobacteriota and Chloroflexi, suggesting that NAR was unfavorable to the survival of Proteobacteria, and Actinobacteria. It is worth noting that the inhibitory or promoting effect of NAR on the dominant bacterial phyla gradually increased with increasing NAR acidity and treatment time. In addition, the study observed that the change in soil pH caused by NAR was the main reason for the change in soil bacterial community structure. In summary, the effects of NAR on soil microorganisms cannot be underestimated from the perspective of sustainable agricultural development. Full article

(This article belongs to the Special Issue Effects of the Soil Microbiome on Nutrient Cycling and Soil Health in Agroecosystems)

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15 pages, 632 KiB

Open AccessArticle

Savoring Belief, Resilience, and Meaning in Life as Pathways to Happiness: A Sequential Mediation Analysis among Taiwanese University Students

by Der-Fa Chen, Kai-Wen Huang, Wei-Sho Ho and Yao-Chung Cheng

Behav. Sci. 2024, 14(5), 388; https://doi.org/10.3390/bs14050388 (registering DOI) - 05 May 2024

Abstract

In recent decades, scholarly interest has grown in the psychological components of happiness. Savoring belief, or the capacity to attend to, appreciate, and enhance the positive experiences in one’s life, along with resilience and meaning in life, have emerged as significant predictors of [...] Read more.

In recent decades, scholarly interest has grown in the psychological components of happiness. Savoring belief, or the capacity to attend to, appreciate, and enhance the positive experiences in one’s life, along with resilience and meaning in life, have emerged as significant predictors of enhanced happiness among diverse populations. This research examined the interrelationships among savoring belief, resilience, meaning in life, and happiness. A sample of 561 students from 75 universities in Taiwan, comprising 361 female and 200 male participants with an average age of 20.88 years, participated in an online survey. The study employed various instruments, including the Savoring Belief Inventory, the Subjective Happiness Scale, the Brief Resilience Scale, and the Meaning in Life Questionnaire. These instruments were translated into Traditional Chinese using a back-translation method and subsequently validated for accuracy by specialists in the field. Analysis of the data using Hayes’ PROCESS Model 6 revealed several key insights: (1) savoring belief positively influenced happiness, resilience, and meaning in life with resilience further enhancing happiness and meaning in life; (2) resilience served as a significant mediator in the relationship between savoring belief and happiness; (3) meaning in life significantly mediated the relationship between savoring belief and happiness; (4) a sequential mediation model illustrated the mediating effects of resilience and meaning in life on the relationship between savoring belief and happiness. This study illustrates that, much like a garden requires water, sunlight, and care to flourish, our happiness is cultivated through enhancing our ability to savor the good moments, rebound from challenges, and find deep significance in our lives. We can significantly boost well-being by fostering these qualities—savoring belief, resilience, and a sense of meaning. These findings are particularly relevant for educators, highlighting the critical need to develop these traits in students to promote greater happiness and fulfillment in their lives. Discussions included theoretical implications, educational implications, and avenues for future research. Full article

(This article belongs to the Topic Personality, Health and Well-Being among Different Age Groups)

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22 pages, 2584 KiB

Open AccessArticle

Investigation of Energy and Power Characteristics of Various Matrix Multiplication Algorithms

by Salem Alsari and Muhammad Al-Hashimi

Energies 2024, 17(9), 2225; https://doi.org/10.3390/en17092225 (registering DOI) - 05 May 2024

Abstract

This work studied the energy behavior of six matrix multiplication algorithms with various physical asset usage patterns. Two were variants of the straight inner product of rows and columns. The rest were variants of Strassen’s divide-and-conquer. Cases varied in ways that were expected [...] Read more.

This work studied the energy behavior of six matrix multiplication algorithms with various physical asset usage patterns. Two were variants of the straight inner product of rows and columns. The rest were variants of Strassen’s divide-and-conquer. Cases varied in ways that were expected to affect energy behavior. The study collected data for square matrix dimensions up to 4000. The research used reliable on-chip integrated voltage regulators embedded in a recent HPC-class AMD CPU for power measurements. Inner product methods used much less energy than the others for small to moderately large matrices. The advantage diminished for sufficiently large dimensions. The power draw of the inner product methods was less for small dimensions. After a point, the power advantage shifted significantly in favor of the divide-and-conquer group (average of 24% better), with the more block-optimized versions showing increased power efficiency (at least 8.3% better than the base method). The study explored the interplay between algorithm design, power efficiency, and computational resources. It aims to help advance the cause of power efficiency in HPC and other scenarios that rely on this vital computation. Full article

(This article belongs to the Topic Condition Monitoring and Diagnostic Methods for Power Equipment in New Energy Power Systems)

23 pages, 7846 KiB

Open AccessArticle

Adsorption Efficiency of Cadmium (II) by Different Alkali-Activated Materials

by Nataša Mladenović Nikolić, Ljiljana Kljajević, Snežana S. Nenadović, Jelena Potočnik, Sanja Knežević, Sabina Dolenec and Katarina Trivunac

Gels 2024, 10(5), 317; https://doi.org/10.3390/gels10050317 (registering DOI) - 05 May 2024

Abstract

The objective of this study was to demonstrate the potential utilization of fly ash (FA), wood ash (WA), and metakaolin (MK) in developing new alkali-activated materials (AAMs) for the removal of cadmium ions from waste water. The synthesis of AAMs involved the dissolution [...] Read more.

The objective of this study was to demonstrate the potential utilization of fly ash (FA), wood ash (WA), and metakaolin (MK) in developing new alkali-activated materials (AAMs) for the removal of cadmium ions from waste water. The synthesis of AAMs involved the dissolution of solid precursors, FA, WA, and MK, by a liquid activator (Na₂SiO₃ and NaOH). In concentrated solutions of the activator, the formation of an aluminosilicate gel structure occurred. DRIFT spectroscopy of the AAMs indicated main vibration bands between 1036 cm⁻¹ and 996 cm⁻¹, corresponding to Si-O-Si/Si-O-Al bands. Shifting vibration bands were seen at 1028 cm⁻¹ to 1021 cm⁻¹, indicating that the Si-O-Si/Si-O-Al bond is elongating, and the bond angle is decreasing. Based on the X-ray diffraction results, alkali-activated samples consist of an amorphous phase and residual mineral phases. The characteristic “hump” of an amorphous phase in the range from 20 to 40° 2θ was observed in FA and in all AWAFA samples. By the XRD patterns of the AAMs obtained by the activation of a solid three-component system, a new crystalline phase, gehlenite, was identified. The efficiency of AAMs in removing cadmium ions from aqueous solutions was tested under various conditions. The highest values of adsorption capacity, 64.76 mg/g (AWAFA₆), 67.02 mg/g (AWAFAMK₆), and 72.84 mg/g mg/g (AWAMK₆), were obtained for materials activated with a 6 M NaOH solution in the alkali activator. The Langmuir adsorption isotherm and pseudo-second kinetic order provided the best fit for all investigated AAMs. Full article

(This article belongs to the Special Issue Physical and Mechanical Properties of Polymer Gels (2nd Edition))

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16 pages, 4672 KiB

Open AccessArticle

Supramolecular Gels Based on C₃-Symmetric Amides: Application in Anion-Sensing and Removal of Dyes from Water

by Geethanjali Kuppadakkath, Sreejith Sudhakaran Jayabhavan and Krishna K. Damodaran

Molecules 2024, 29(9), 2149; https://doi.org/10.3390/molecules29092149 (registering DOI) - 05 May 2024

Abstract

We modified C₃-symmetric benzene-1,3,5-tris-amide (BTA) by introducing flexible linkers in order to generate an N-centered BTA (N-BTA) molecule. The N-BTA compound formed gels in alcohols and aqueous mixtures of high-polar solvents. Rheological studies showed that the DMSO/water (1:1, v [...] Read more.

We modified C₃-symmetric benzene-1,3,5-tris-amide (BTA) by introducing flexible linkers in order to generate an N-centered BTA (N-BTA) molecule. The N-BTA compound formed gels in alcohols and aqueous mixtures of high-polar solvents. Rheological studies showed that the DMSO/water (1:1, v/v) gels were mechanically stronger compared to other gels, and a similar trend was observed for thermal stability. Powder X-ray analysis of the xerogel obtained from various aqueous gels revealed that the packing modes of the gelators in these systems were similar. The stimuli-responsive properties of the N-BTA towards sodium/potassium salts indicated that the gel network collapsed in the presence of more nucleophilic anions such as cyanide, fluoride, and chloride salts at the MGC, but the gel network was intact when in contact with nitrate, sulphate, acetate, bromide, and iodide salts, indicating the anion-responsive properties of N-BTA gels. Anion-induced gel formation was observed for less nucleophilic anions below the MGC of N-BTA. The ability of N-BTA gels to act as an adsorbent for hazardous anionic and cationic dyes in water was evaluated. The results indicated that the ethanolic gels of N-BTA successfully absorbed methylene blue and methyl orange dyes from water. This work demonstrates the potential of the N-BTA gelator to act as a stimuli-responsive material and a promising candidate for water purification. Full article

(This article belongs to the Special Issue Chemistry of Materials for Energy and Environmental Sustainability)

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