Under extreme conditions such as high speed and heavy load, 18Cr2Ni4WA steel cannot meet the service requirements even after carburizing and quenching processes. In order to obtain better surface mechanical properties and tribological property, a hollow cathode ion source diffusion strengthening device was used to nitride the traditional carburizing and quenching samples. Unlike traditional ion carbonitriding technology, the low-temperature ion carbonitriding technology used in this article can increase the surface hardness of the material by 50% after 3 h of treatment, from the original 600 HV_0.1 to 900 HV_0.1, while the core hardness only decreases by less than 20%. The effect of post-ion carbonitriding treatment on mechanical properties and tribological properties of the carburized and quenched 18Cr2Ni4WA steel was investigated. Samples in different treatment are characterized using optical microscopy (OM), scanning electron microscopy (SEM), optimal SRV-4 high temperature tribotester, as well as Vickers hardness tester. Under two conditions of 6N light load and 60 N heavy load, compared with untreated samples, the wear rate of ion carbonitriding samples decreased by more than 99%, while the friction coefficient remained basically unchanged. Furthermore, the careful selection of ion nitrocarburizing and carburizing tempering temperatures in this study has been shown to significantly enhance surface hardness and wear resistance, while preserving the overall hardness of the carburized sample. The present study demonstrates the potential of ion carbonitriding technology as a viable post-treatment method for carburized gears. Full article

The analysis and simulation of water quality in distribution networks is a complex issue of great concern today. The analysis of the evolution of water age as a simple indicator of water quality in the network is of great interest in both the design and operation phases. Understanding the factors that have the strongest influence on water quality is key to developing adequate strategies aimed at preserving it. This paper first analyses the factors with the biggest influence on the tank’s water age to support the selection of the most appropriate configuration from the point of view of water quality during design phases. Then, the main considerations when modelling tanks following the different mixing models considered in Epanet are presented. Also, real tank behaviour is characterised through field measurements and Epanet simulations in order to determine the best-fitting mixing model. Full article

This study presents a data-driven model for identifying failure modes (FMs) and predicting the corresponding punching shear resistance of slab-column connections with shear reinforcement. An experimental database that contains 328 test results is used to determine nine input variables based on the punching shear mechanism. A comparison is conducted between three typical machine learning (ML) approaches: random forest (RF), light gradient boosting machine (LightGBM), extreme gradient boosting (XGBoost) and two hybrid optimized algorithms: grey wolf optimization (GWO) and whale optimization algorithm (WOA). It was found that the XGBoost classifier had the highest accuracy rate, precision, and recall values for FM identification. In testing, WOA-XGBoost has the best accuracy in predicting punching shear resistance, with R², MAE, and RMSE values of 0.9642, 0.087 MN, and 0.126 MN, respectively. However, a comparison between experimental values and calculated values derived from classical analytical methods clearly demonstrates that existing design codes need to be improved. Additionally, Shapley additive explanations (SHAP) were applied to explain the model’s predictions, with factors categorized according to their impact on failure modes and punching shear resistance. By modifying these parameters, punching resistance can be improved while reducing unpredictable failure. With the proposed hybrid algorithms, it is possible to determine the failure modes and the punching shear resistance of slabs during the preliminary stages of the construction. Full article

Mild Cognitive Impairment (MCI) is a cognitive state frequently observed in older adults, characterized by significant alterations in memory, thinking, and reasoning abilities that extend beyond typical cognitive decline. It is worth noting that around 10–15% of individuals with MCI are projected to develop Alzheimer’s disease, effectively positioning MCI as an early stage of Alzheimer’s. In this study, a novel approach is presented involving the utilization of eXtreme Gradient Boosting to predict the onset of Alzheimer’s disease during the MCI stage. The methodology entails utilizing data from the Alzheimer’s Disease Neuroimaging Initiative (ADNI). Through the analysis of longitudinal data, spanning from the baseline visit to the 12-month follow-up, a predictive model was constructed. The proposed model calculates, over a 36-month period, the likelihood of progression from MCI to Alzheimer’s disease, achieving an accuracy rate of 85%. To further enhance the precision of the model, this study implements feature selection using the Recursive Feature Elimination technique. Additionally, the Shapley method is employed to provide insights into the model’s decision-making process, thereby augmenting the transparency and interpretability of the predictions. Full article

Currently, more than 55 million people around the world suffer from dementia, and Alzheimer’s Disease and Related Dementias (ADRD) accounts for nearly 60–70% of all those cases. The spread of Alzheimer’s Disease (AD) pathology and progressive neurodegeneration in the hippocampus and cerebral cortex is strongly correlated with cognitive decline in AD patients; however, the molecular underpinning of ADRD’s causality is still unclear. Studies of postmortem AD brains and animal models of AD suggest that elevated endoplasmic reticulum (ER) stress may have a role in ADRD pathology through altered neurocellular homeostasis in brain regions associated with learning and memory. To study the ER stress-associated neurocellular response and its effects on neurocellular homeostasis and neurogenesis, we modeled an ER stress challenge using thapsigargin (TG), a specific inhibitor of sarco/endoplasmic reticulum Ca²⁺ ATPase (SERCA), in the induced pluripotent stem cell (iPSC)-derived neural stem cells (NSCs) of two individuals from our Mexican American Family Study (MAFS). High-content screening and transcriptomic analysis of the control and ER stress-challenged NSCs showed that the NSCs’ ER stress response resulted in a significant decline in NSC self-renewal and an increase in apoptosis and cellular oxidative stress. A total of 2300 genes were significantly (moderated t statistics FDR-corrected p-value ≤ 0.05 and fold change absolute ≥ 2.0) differentially expressed (DE). The pathway enrichment and gene network analysis of DE genes suggests that all three unfolded protein response (UPR) pathways, protein kinase RNA-like ER kinase (PERK), activating transcription factor-6 (ATF-6), and inositol-requiring enzyme-1 (IRE1), were significantly activated and cooperatively regulated the NSCs’ transcriptional response to ER stress. Our results show that IRE1/X-box binding protein 1 (XBP1) mediated transcriptional regulation of the E2F transcription factor 1 (E2F1) gene, and its downstream targets have a dominant role in inducing G1/S-phase cell cycle arrest in ER stress-challenged NSCs. The ER stress-challenged NSCs also showed the activation of C/EBP homologous protein (CHOP)-mediated apoptosis and the dysregulation of synaptic plasticity and neurotransmitter homeostasis-associated genes. Overall, our results suggest that the ER stress-associated attenuation of NSC self-renewal, increased apoptosis, and dysregulated synaptic plasticity and neurotransmitter homeostasis plausibly play a role in the causation of ADRD. Full article

(1) Background: With autistic children’s high pervasiveness of eating problems and inappropriate feeding behaviors by their caregivers, this study wanted to inspect the connection between caregivers’ pressure to eat and food neophobia in these children. (2) Methods: Cross-sectional overview of 160 guardians of kids aged 2 to 7 years. After one-on-one questioning by the researcher, the collected information on the socio-demographic characteristics of the children with autism, caregiver feeding behavior, and new food neophobia (FN) scores was entered into the Questionnaire Star system. (3) Results: The mean FN score was 25.56 ± 6.46. The caregiver’s pressure to eat positively related to children’s FN (β = 0.164 95% CI, 0.078, 2.163). In these children, we found a negative correlation between FN score and the frequency of vegetable intake (p ≤ 0.001), fruit intake (p ≤ 0.05), aquatic product intake (p ≤ 0.05), and dietary diversity score (p ≤ 0.01), and positively correlated with the frequency of snack intake (p ≤ 0.05). (4) Conclusions: Caregiver pressure to eat was positively associated with high levels of FN in Chinese kids with ASD, which in turn negatively impacted dietary quality. To improve eating habits, caregivers should reconsider their feeding strategies and avoid using forceful methods to ease food neophobia in these children. Full article

The relationship between epicardial adipose tissue (EAT) and atrial fibrillation (AF) has gained interest in recent years. The previous literature on the topic presents great heterogeneity, focusing especially on computed tomography imaging. The aim of the present study is to determine whether an increased volume of left atrial (LA) EAT evaluated at routine pre-procedural cardiac magnetic resonance imaging (MRI) relates to AF recurrences after catheter ablation. A total of 50 patients undergoing AF cryoballoon ablation and pre-procedural cardiac MRI allowing quantification of LA EAT were enrolled. In one patient, the segmentation of LA EAT could not be achieved. After a median follow-up of 16.0 months, AF recurrences occurred in 17 patients (34%). The absolute volume of EAT was not different in patients with and without AF recurrences (10.35 mL vs. 10.29 mL; p-value = 0.963), whereas the volume of EAT indexed on the LA volume (EATi) was lower, albeit non-statistically significant, in patients free from arrhythmias (12.77% vs. 14.06%; p-value = 0.467). The receiver operating characteristic curve testing the ability of LA EATi to predict AF recurrence after catheter ablation showed sub-optimal performance (AUC: 0.588). The finest identified cut-off of LA EATi was 10.65%, achieving a sensitivity of 0.5, a specificity of 0.82, a positive predictive value of 0.59 and a negative predictive value of 0.76. Patients with values of LA EATi lower than 10.65% showed greater survival, free from arrhythmias, than patients with values above this cut-off (84% vs. 48%; p-value = 0.04). In conclusion, EAT volume indexed on the LA volume evaluated at cardiac MRI emerges as a possible independent predictor of arrhythmia recurrence after AF cryoballoon ablation. Nevertheless, prospective studies are needed to confirm this finding and eventually sustain routine EAT evaluation in the management of patients undergoing AF catheter ablation. Full article

Dealing with and maintaining high-quality standards in the design and construction phases is challenging, especially for on-site construction. Issues like improper implementation of building components and poor communication can widen the gap between design specifications and actual conditions. To prevent this, particularly for energy-efficient buildings, it is vital to develop resilient, sustainable strategies. These should optimize resource use, minimize environmental impact, and enhance livability, contributing to carbon neutrality by 2050 and climate change mitigation. Traditional post-occupancy evaluations, which identify defects after construction, are impractical for addressing energy performance gaps. A new, real-time inspection approach is necessary throughout the construction process. This paper suggests an innovative guideline for prefabricated buildings, emphasizing digital ‘self-instruction’ and ‘self-inspection’. These procedures ensure activities impacting quality adhere to specific instructions, drawings, and 3D models, incorporating the relevant acceptance criteria to verify completion. This methodology, promoting alignment with planned energy-efficient features, is supported by BIM-based software and Augmented Reality (AR) tools, embodying Industry 4.0 principles. BIM (Building Information Modeling) and AR bridge the gap between virtual design and actual construction, improving stakeholder communication and enabling real-time monitoring and adjustments. This integration fosters accuracy and efficiency, which are key for energy-efficient and nearly zero-energy buildings, marking a shift towards a more precise, collaborative, and environmentally sensible construction industry. Full article

Reducing production costs, known as scaling, is a significant obstacle in the advancement of cultivated meat. The cultivation process hinges on several key components, e.g., cells, media, scaffolds, and bioreactors. This study demonstrates an innovative approach, departing from traditional stainless steel or glass bioreactors, by integrating food-grade plant-based scaffolds and thermoplastic film bioreactors. While thermoplastic films are commonly used for constructing fluidic systems, conventional welding methods are cost-prohibitive and lack rapid prototyping capabilities, thus inflating research and development expenses. The developed laser welding technique facilitates contamination-free and leakproof sealing of polyethylene films, enabling the efficient fabrication of macrofluidic systems with various designs and dimensions. By incorporating food-grade plant-based scaffolds, such as rice seeded with bovine mesenchymal stem cells, into these bioreactors, this study demonstrates sterile cell proliferation on scaffolds within macrofluidic systems. This approach not only reduces bioreactor prototyping and construction costs but also addresses the need for scalable solutions in both research and industrial settings. Integrating single-use bioreactors with minimal shear forces and incorporating macro carriers such as puffed rice may further enhance biomass production in a scaled-out model. The use of food-grade plant-based scaffolds aligns with sustainable practices in tissue engineering and cultured-meat production, emphasizing its suitability for diverse applications. Full article

Remote sensing datasets usually have a wide range of spatial and spectral resolutions. They provide unique advantages in surveillance systems, and many government organizations use remote sensing multispectral imagery to monitor security-critical infrastructures or targets. Artificial Intelligence (AI) has advanced rapidly in recent years and has been widely applied to remote image analysis, achieving state-of-the-art (SOTA) performance. However, AI models are vulnerable and can be easily deceived or poisoned. A malicious user may poison an AI model by creating a stealthy backdoor. A backdoored AI model performs well on clean data but behaves abnormally when a planted trigger appears in the data. Backdoor attacks have been extensively studied in machine learning-based computer vision applications with natural images. However, much less research has been conducted on remote sensing imagery, which typically consists of many more bands in addition to the red, green, and blue bands found in natural images. In this paper, we first extensively studied a popular backdoor attack, BadNets, applied to a remote sensing dataset, where the trigger was planted in all of the bands in the data. Our results showed that SOTA defense mechanisms, including Neural Cleanse, TABOR, Activation Clustering, Fine-Pruning, GangSweep, Strip, DeepInspect, and Pixel Backdoor, had difficulties detecting and mitigating the backdoor attack. We then proposed an explainable AI-guided backdoor attack specifically for remote sensing imagery by placing triggers in the image sub-bands. Our proposed attack model even poses stronger challenges to these SOTA defense mechanisms, and no method was able to defend it. These results send an alarming message about the catastrophic effects the backdoor attacks may have on satellite imagery. Full article

The optimization of the spatial structure of the city network is conducive to the scientific spatial distribution of industries and the promotion of coordinated regional development. This study selected the top 100 automobile enterprises in the Chinese stock market that belong to China’s pillar industry, a total of 1455 headquarters and branches, to establish an enterprise matrix. Based on the ownership linkage model, the evolution characteristics of city networks in China from 2000 to 2020 are revealed, and the influential factors of city networks are discussed using the negative binomial regression model. The findings are as follows: (1) there are significant differences in the status of automobile cities, forming a “pyramid network” hierarchy. (2) The agglomeration area of automobile cities has formed the development region of “4 + 4 + 1”. (3) The city network with hierarchical connections has formed a spatial structure of a “cross–cobweb” in the middle and “trapezoid–diamond” in the periphery. (4) Urban transportation conditions, the scientific research environment, the enterprise agglomeration economy, GDP per capita, and technological proximity positively impact the formation of a city network, but the total export–import volume has a negative impact. Overall, the government can use this study’s results to formulate policies for the automotive industry and urban development. Full article

We review the role of the spectral condition as a characteristic of Minkowski, de Sitter, and anti-de Sitter quantum field theories. We also discuss the role of plane waves that are compatible with the relevant analyticity domains linked to the spectral condition(s) and discuss harmonic analysis in terms of them. Full article

Ships connect the global economy through maritime transport. However, their susceptibility to increasing geopolitical conflicts has heightened concerns about the risks to crew safety and navigation security. This systematic literature review (SLR), utilizing the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) framework, rigorously examines the safety and security of autonomous ships in maritime transport. The methodology employs a comprehensive search across major databases including Scopus, Google Scholar, and Science Direct, based on explicit inclusion criteria focusing on recent advancements from 2014 to 2023. By methodically analyzing 58 relevant publications screened from an initial pool of 1407, this paper highlights critical trends and gaps in the application of advanced sensor technologies, cybersecurity measures, and autonomous navigation systems. The findings provide insights into the operational challenges and technological developments shaping the future of maritime safety and security, offering valuable guidance for policymakers and industry stakeholders. This research contributes to scholarly discourse in this industry by mapping the trajectory of technological integration and its implications for maritime operations in a global context. Full article

The spatiotemporal expression patterns of genes are crucial for maintaining normal physiological functions in animals. Conditional gene knockout using the cyclization recombination enzyme (Cre)/locus of crossover of P1 (Cre/LoxP) strategy has been extensively employed for functional assays at specific tissue or developmental stages. This approach aids in uncovering the associations between phenotypes and gene regulation while minimizing interference among distinct tissues. Various Cre-engineered mouse models have been utilized in the male reproductive system, including Dppa3-MERCre for primordial germ cells, Ddx4-Cre and Stra8-Cre for spermatogonia, Prm1-Cre and Acrv1-iCre for haploid spermatids, Cyp17a1-iCre for the Leydig cell, Sox9-Cre for the Sertoli cell, and Lcn5/8/9-Cre for differentiated segments of the epididymis. Notably, the specificity and functioning stage of Cre recombinases vary, and the efficiency of recombination driven by Cre depends on endogenous promoters with different sequences as well as the constructed Cre vectors, even when controlled by an identical promoter. Cre mouse models generated via traditional recombination or CRISPR/Cas9 also exhibit distinct knockout properties. This review focuses on Cre-engineered mouse models applied to the male reproductive system, including Cre-targeting strategies, mouse model screening, and practical challenges encountered, particularly with novel mouse strains over the past decade. It aims to provide valuable references for studies conducted on the male reproductive system. Full article

The aim of this study was to determine the associations between the front and back squat, countermovement jump (CMJ) and deep squat jump (DSJ) force–time metrics, and weightlifting performance in top-level weightlifters. Thirteen top-level weightlifters who classified for the World Championship 2023 participated. The heaviest successful snatch and clean and jerk were recorded within a preparation session as performance indicators. The front and back squat one-repetition maximums (1RMs) were evaluated in separate training sessions. The average of three maximum CMJs and DSJs were recorded using a force plate, and jump height, propulsive net impulse, and peak power were calculated for further analysis. Pearson’s correlation coefficients were used to determine the associations between variables. Statistical significance was set at p ≤ 0.05. The front and back squat 1RMs were significant and nearly perfectly associated with weightlifting performance (p < 0.001, r = 0.98–0.99). CMJ and DSJ propulsive net impulse displayed nearly perfect associations with weightlifting performance (p < 0.001, r = 0.96–0.99), while jump height is a less promising metric to assess the weightlifters’ ballistic capabilities. This study reinforces that lower body maximum strength and ballistic capabilities are closely associated with top-level weightlifters’ performance and are of practical importance to monitor their neuromuscular function. Full article

Spillways are essential control structures in hydroelectric dams for evacuating excess water during periods of high-water flow. These structures are generally excavated within a rock mass, without lining, and they take the form of a flow channel or a plunge pool. Rock mass erosion is an important issue facing engineers when designing unlined spillways. Methods commonly used to analyze this phenomenon are based on the threshold line concept, i.e., the correlation between rock mass resistance and its destruction against the erosive force of water. Multiple indices have been proposed for both rock mass quality and water energy (or erosive force) to assess rock mass erosion. The selection of appropriate indices is critical when evaluating hydraulic erosion. The erosive force of water is often represented by energy dissipation; however, other parameters, including average flow velocity and shear stress at the bottom of the flow channel, may also be relevant. Thus, a critical question is framed: which index best represents the erosive force of water? Here, we develop an approach to assess the applicability of the various indices used to represent the erosive force of water by relying on erosional events at more than 100 study sites. We determine that the most relevant parameters are linked to water pressure, as pressure head and flow velocity better explain the erosive force of the water than shear stress and water dissipation energy. Full article

Puerto de Cajas serves as a vital high-altitude passage in Ecuador, connecting the coastal region to the city of Cuenca. The stability of this rocky massif is carefully managed through the assessment of blocks and discontinuities, ensuring safe travel. This study presents a novel approach, employing rapid and cost-effective methods to evaluate an unexplored area within the protected expanse of Cajas. Using terrestrial photogrammetry and strategically positioned geomechanical stations along the slopes, we generated a detailed point cloud capturing elusive terrain features. We have used terrestrial photogrammetry for digitalization of the slope. Validation of the collected data was achieved by comparing directional data from Cloud Compare software with manual readings using a digital compass integrated in a phone at control points. The analysis encompasses three slopes, employing the SMR, Q-slope, and kinematic methodologies. Results from the SMR system closely align with kinematic analysis, indicating satisfactory slope quality. Nonetheless, continued vigilance in stability control remains imperative for ensuring road safety and preserving the site’s integrity. Moreover, this research lays the groundwork for the creation of a publicly accessible 3D repository, enhancing visualization capabilities through Google Virtual Reality. This initiative not only aids in replicating the findings but also facilitates access to an augmented reality environment, thereby fostering collaborative research endeavors. Full article

Meat quality and shelf life are important parameters affecting consumer perception and safety. Several factors contribute to the deterioration and spoilage of meat products, including microbial growth, chemical reactions in the food’s constituents, protein denaturation, lipid oxidation, and discoloration. This study reviewed the development of functional packaging biomaterials that interact with food and the environment to improve food’s sensory properties and consumer safety. Bioactive packaging incorporates additive compounds such as essential oils, natural extracts, and chemical substances to produce composite polymers and polymer blends. The findings showed that the incorporation of additive compounds enhanced the packaging’s functionality and improved the compatibility of the polymer–polymer matrices and that between the polymers and active compounds. Food preservatives are alternative substances for food packaging that prevent food spoilage and preserve quality. The safety of food contact materials, especially the flavor/odor contamination from the packaging to the food and the mass transfer from the food to the packaging, was also assessed. Flavor is a key factor in consumer purchasing decisions and also determines the quality and safety of meat products. Novel functional packaging can be used to preserve the quality and safety of packaged meat products. Full article

The COVID-19 pandemic significantly impacted global development. Through bioaerosols emitted by human respiration, respiratory infectious diseases, including COVID-19, are transmitted. The bioaerosol concentrations can be affected by the urban climate and morphology. However, the effects of urban green spaces on bioaerosol concentrations remain unclear. Focusing on the dormitory area of Beijing Forestry University, this study first investigated the influence of different green space ratios on the average bioaerosol concentrations using the ENVI-met software. Moreover, both overall and local green space layouts were analyzed for their impact on bioaerosol concentrations. The results indicated that ventilation conditions were the primary factor influencing bioaerosol concentrations. During peak congestion, a 10% increase in the green space ratio resulted in a 2% rise in the average bioaerosol concentration. Furthermore, a distributed layout resulted in a 1.3% higher average bioaerosol concentration than a concentrated layout with an equivalent green space ratio. Enacting strategies such as Roadside Green Spaces Retreat, Road Spaces Expansion, and Intersection Green Spaces Chamfering led to reductions in local bioaerosol concentrations by up to 17.7%, 18.44%, and 12.69%, respectively. This study highlights the importance of adjusting green space layouts in urban high-density areas after the pandemic, reducing the risk of population exposure to bioaerosol concentrations. Full article

This paper examines the effects of collapsible soil structure on shear wave velocity. The study attempts to simulate hydraulic fill sand deposits, which represent a natural soil deposition process that can result in a collapsible soil structure. A series of resonant column tests and bender element tests on Ottawa sand was conducted on sand specimens and prepared by dry pluviation and simulated hydraulic fill methods subjected to various confining pressures. Shear wave velocities measured from both methods of deposition are compared and discussed. Results from this study show that for soil specimens with the same void ratio, samples prepared by simulated hydraulic fill have a lower shear modulus and shear wave velocity than the specimens prepared by dry pluviation, and the differences are more pronounced at higher confining pressures. The resonant column test results performed in this study were consistent with results from the discrete element analysis, full-scale testing, and centrifuge testing. The discrete element analysis suggests that soil fabric and number of particle contacts are the key factors affecting the shear wave velocity. These factors are dependent on the methods of deposition. Results from this study examining hydraulic fill collapsible structure shear wave velocity provide a step forward toward a better correlation between soil dynamic properties measured in field and laboratory tests. Full article

This article proposes a new deadbeat predictive current control (DPCC) method based on a sliding-mode observer (SMO), which is applied in the field of permanent magnet motor control. A novel DPCC control method based on SMO is proposed according to the inherent issues of DPCC, which can effectively suppress internal parameter mismatch disturbances and external disturbances in the current loop. The mathematical model and derivation process of the proposed method are introduced. A simulation model is built and the effectiveness of the proposed method is verified. An experimental platform is built and the superiority of the proposed method is verified based on comparative experiments. Experimental results show that the proposed algorithm has strong robustness to the motor parameter mismatch. Compared with extended state observer (ESO) and adaptive observer (AO), the proposed algorithm has faster response speed and higher steady-state accuracy. Full article

The condition of a catenary is significant to ensure a high current collection quality. Owing to the dynamic interaction between the pantograph and the catenary system, the vibration of the pantograph can be used to analyze the condition of the catenary system. Therefore, we developed a novel diagnosis system based on the correlation between catenary defects and pantograph vibration. The proposed system is capable of detecting the type and location of commonly encountered defects in rigid support catenary systems. Catenary positioning coefficient and enhanced sample entropy methods were proposed for the extraction of defect features, and subsequently, linear discriminate analysis was used to diagnose the type and location of the catenary defects. Finally, the proposed defect detection and diagnosis system was applied to a commercial metro line, and the results verified the reliability and effectiveness of this diagnosis system. Full article