The 2023 MDPI Annual Report has
been released!
 
19 pages, 2074 KiB  
Article
Nucleotide-Binding Oligomerization Domain 1 (NOD1) Agonists Prevent SARS-CoV-2 Infection in Human Lung Epithelial Cells through Harnessing the Innate Immune Response
by Edurne Garcia-Vidal, Ignasi Calba, Eva Riveira-Muñoz, Elisabet García, Bonaventura Clotet, Pere Serra-Mitjà, Cecilia Cabrera, Ester Ballana and Roger Badia
Int. J. Mol. Sci. 2024, 25(10), 5318; https://doi.org/10.3390/ijms25105318 (registering DOI) - 13 May 2024
Abstract
The lung is prone to infections from respiratory viruses such as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). A challenge in combating these infections is the difficulty in targeting antiviral activity directly at the lung mucosal tract. Boosting the capability of the respiratory [...] Read more.
The lung is prone to infections from respiratory viruses such as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). A challenge in combating these infections is the difficulty in targeting antiviral activity directly at the lung mucosal tract. Boosting the capability of the respiratory mucosa to trigger a potent immune response at the onset of infection could serve as a potential strategy for managing respiratory infections. This study focused on screening immunomodulators to enhance innate immune response in lung epithelial and immune cell models. Through testing various subfamilies and pathways of pattern recognition receptors (PRRs), the nucleotide-binding and oligomerization domain (NOD)-like receptor (NLR) family was found to selectively activate innate immunity in lung epithelial cells. Activation of NOD1 and dual NOD1/2 by the agonists TriDAP and M-TriDAP, respectively, increased the number of IL-8+ cells by engaging the NF-κB and interferon response pathways. Lung epithelial cells showed a stronger response to NOD1 and dual NOD1/2 agonists compared to control. Interestingly, a less-pronounced response to NOD1 agonists was noted in PBMCs, indicating a tissue-specific effect of NOD1 in lung epithelial cells without inducing widespread systemic activation. The specificity of the NOD agonist pathway was confirmed through gene silencing of NOD1 (siRNA) and selective NOD1 and dual NOD1/2 inhibitors in lung epithelial cells. Ultimately, activation induced by NOD1 and dual NOD1/2 agonists created an antiviral environment that hindered SARS-CoV-2 replication in vitro in lung epithelial cells. Full article
(This article belongs to the Special Issue Viral and Host Targets to Fight RNA Viruses)
35 pages, 775 KiB  
Article
A Decision-Making Model Proposal for the Use of Renewable Energy Technologies in Buildings in Turkey
by Fatma Cesur, Nilüfer Taş and Murat Taş
Energies 2024, 17(10), 2354; https://doi.org/10.3390/en17102354 (registering DOI) - 13 May 2024
Abstract
With the increasing need for energy, issues related to using energy efficiently in buildings and employing renewable energy technologies are gaining significance. The building production process is intricate, involving numerous stakeholders, multiple decisions, and a combination of qualitative and quantitative data. This process [...] Read more.
With the increasing need for energy, issues related to using energy efficiently in buildings and employing renewable energy technologies are gaining significance. The building production process is intricate, involving numerous stakeholders, multiple decisions, and a combination of qualitative and quantitative data. This process necessitates decision making based on specific requirements. The objective of this study is to identify effective criteria in decision making concerning the use of renewable energy technologies (RETs) in buildings in Turkey. It aims to highlight the importance of these criteria and compare them, and it also aims to define a recommendation decision-making model for the widespread adoption of renewable energy technologies. This study employed qualitative and quantitative research methods. Based on information gathered from the literature, the main criteria and sub-criteria for RET utilization were determined through in-depth interviews with an expert group, including individuals influencing the building design process (architects, engineers, consultants, employers, and users). A recommendation model was developed using the analytic hierarchy process method to highlight the significance of the identified criteria, compare the criteria and technologies, and facilitate the selection of the most-appropriate technology. This study demonstrates that the decision-making model can be utilized in determining RET-related criteria in the building production process, establishing their weights, and make informed decisions regarding the appropriate technology. Full article
(This article belongs to the Section G: Energy and Buildings)
19 pages, 398 KiB  
Article
Parameter Choice Strategy that Computes Regularization Parameter before Computing the Regularized Solution
by Santhosh George, Jidesh Padikkal, Ajil Kunnarath, Ioannis K. Argyros and Samundra Regmi
Modelling 2024, 5(2), 530-548; https://doi.org/10.3390/modelling5020028 (registering DOI) - 13 May 2024
Abstract
The modeling of many problems of practical interest leads to nonlinear ill-posed equations (for example, the parameter identification problem (see the Numerical section)). In this article, we introduce a new source condition (SC) and a new parameter choice strategy (PCS) for the Tikhonov [...] Read more.
The modeling of many problems of practical interest leads to nonlinear ill-posed equations (for example, the parameter identification problem (see the Numerical section)). In this article, we introduce a new source condition (SC) and a new parameter choice strategy (PCS) for the Tikhonov regularization (TR) method for nonlinear ill-posed problems. The new PCS is introduced using a new SC to compute the regularization parameter (RP) before computing the regularized solution. The theoretical results are verified using a numerical example. Full article
17 pages, 621 KiB  
Article
Assessing the Relationship between Surgical Timing and Postoperative Seizure Outcomes in Cavernoma-Related Epilepsy: A Single-Institution Retrospective Analysis of 63 Patients with a Review of the Literature
by Elsa Nico, Christopher O. Adereti, Ashia M. Hackett, Andrea Bianconi, Anant Naik, Adam T. Eberle, Pere J. Cifre Serra, Stefan W. Koester, Samuel L. Malnik, Brandon M. Fox, Joelle N. Hartke, Ethan A. Winkler, Joshua S. Catapano and Michael T. Lawton
Brain Sci. 2024, 14(5), 494; https://doi.org/10.3390/brainsci14050494 (registering DOI) - 13 May 2024
Abstract
Background: Patients with supratentorial cavernous malformations (SCMs) commonly present with seizures. First-line treatments for cavernoma-related epilepsy (CRE) include conservative management (antiepileptic drugs (AEDs)) and surgery. We compared seizure outcomes of CRE patients after early (≤6 months) vs. delayed (>6 months) surgery. Methods [...] Read more.
Background: Patients with supratentorial cavernous malformations (SCMs) commonly present with seizures. First-line treatments for cavernoma-related epilepsy (CRE) include conservative management (antiepileptic drugs (AEDs)) and surgery. We compared seizure outcomes of CRE patients after early (≤6 months) vs. delayed (>6 months) surgery. Methods: We compared outcomes of CRE patients with SCMs surgically treated at our large-volume cerebrovascular center (1 January 2010–31 July 2020). Patients with 1 sporadic SCM and ≥1-year follow-up were included. Primary outcomes were International League Against Epilepsy (ILAE) class 1 seizure freedom and AED independence. Results: Of 63 CRE patients (26 women, 37 men; mean ± SD age, 36.1 ± 14.6 years), 48 (76%) vs. 15 (24%) underwent early (mean ± SD, 2.1 ± 1.7 months) vs. delayed (mean ± SD, 6.2 ± 7.1 years) surgery. Most (32 (67%)) with early surgery presented after 1 seizure; all with delayed surgery had ≥2 seizures. Seven (47%) with delayed surgery had drug-resistant epilepsy. At follow-up (mean ± SD, 5.4 ± 3.3 years), CRE patients with early surgery were more likely to have ILAE class 1 seizure freedom and AED independence than those with delayed surgery (92% (44/48) vs. 53% (8/15), p = 0.002; and 65% (31/48) vs. 33% (5/15), p = 0.03, respectively). Conclusions: Early CRE surgery demonstrated better seizure outcomes than delayed surgery. Multicenter prospective studies are needed to validate these findings. Full article
(This article belongs to the Special Issue Cerebrovascular Neurosurgery)
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15 pages, 3448 KiB  
Article
Transcriptome Analysis Elucidates the Potential Key Genes Involved in Rib Development in bmp6-Deficient Silver Carp (Hypophthalmichthys molitrix)
by Xiaohui Li, Chunyan Zhang, Cui Feng, Zewen Zhang, Nannan Feng, Hang Sha, Xiangzhong Luo, Guiwei Zou and Hongwei Liang
Animals 2024, 14(10), 1451; https://doi.org/10.3390/ani14101451 (registering DOI) - 13 May 2024
Abstract
Bone morphogenetic protein 6 (BMP-6) is a constituent of the TGF-β superfamily, known for its ability to stimulate bone and cartilage formation. The investigation of bmp6’s involvement in the formation of intermuscular bones in fish has garnered significant attention in recent years. [...] Read more.
Bone morphogenetic protein 6 (BMP-6) is a constituent of the TGF-β superfamily, known for its ability to stimulate bone and cartilage formation. The investigation of bmp6’s involvement in the formation of intermuscular bones in fish has garnered significant attention in recent years. The rib cage is an important skeletal structure that plays a protective function for internal organs in fish. However, there has been limited research conducted on the effects of the bmp6 gene on rib development. Silver carp is one of four major fish in China, favoured for its affordability and tender muscle. Nevertheless, the presence of numerous intermuscular bones in silver carp significantly hinders the advancement of its palatability and suitability for processing. This study showcases the effective utilisation of CRISPR/Cas9 technology for the purpose of disrupting the bmp6 gene in silver carp, leading to the creation of chimeras in the P0 generation, marking the first instance of such an achievement. The chimeras exhibited complete viability, normal appearance, and partial intermuscular bones loss, with approximately 30% of them displaying rib bifurcation or bending. Subsequently, a transcriptome analysis on ribs of P0 chimeras and wild-type silver carp was conducted, leading to the identification of 934 genes exhibiting differential expression, of which 483 were found to be up-regulated and 451 were found to be down-regulated. The results of the KEGG analysis revealed that the “NF-kappa B signalling pathway”, “Hippo signalling pathway”, “osteoclast differentiation”, and “haematopoietic cell lineage” exhibited enrichment and displayed a significant correlation with bone development. The up-regulated genes such as tnfα, fos, and ctgf in pathways may facilitate the proliferation and differentiation of osteoclasts, whereas the down-regulation of genes such as tgfb2 and tgfbr1 in pathways may hinder the formation and specialisation of osteoblasts, ultimately resulting in rib abnormalities. This study presents novel findings on the impact of bmp6 gene deletion on the rib development of silver carp, while simultaneously investigating the previously unexplored molecular mechanisms underlying rib defects in fish. Full article
(This article belongs to the Special Issue Genomic and Transcriptomic Studies in Aquaculture)
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11 pages, 405 KiB  
Article
Pulmonary Vein Isolation for Atrial Fibrillation: Comparison of a Very High-Power Very Short-Duration (vHPvSD) Ablation Protocol Versus a Hybrid Ablation Approach—Procedural and Mid-Term Outcome Data
by Alexander Baumgartner, Martin Martinek, Michael Derndorfer, Georgios Kollias, Peter Ammann, Helmut Pürerfellner and Sebastian Seidl
J. Clin. Med. 2024, 13(10), 2879; https://doi.org/10.3390/jcm13102879 (registering DOI) - 13 May 2024
Abstract
Background: Pulmonary vein isolation (PVI) using radiofrequency ablation (RFA) is a standard-of-care treatment in the rhythm control strategy of symptomatic atrial fibrillation (AF). Ablation protocols, varying in the power and duration of energy delivery, have changed rapidly in recent years. Very high-power very [...] Read more.
Background: Pulmonary vein isolation (PVI) using radiofrequency ablation (RFA) is a standard-of-care treatment in the rhythm control strategy of symptomatic atrial fibrillation (AF). Ablation protocols, varying in the power and duration of energy delivery, have changed rapidly in recent years. Very high-power very short-duration ablation (vHPvSD) is expected to shorten procedural times compared to conventional ablation approaches. However, the existing data suggest that this might come at the cost of lower first-pass isolation rates, a predictor of poor ablation long-term outcomes. This study aims to compare a vHPvSD protocol to a hybrid strategy, in which the power and duration of the energy transfer are adapted depending on the anatomical location. Methods: We retrospectively analyzed procedural and outcome data from 93 patients (55 vHPvSD vs. 38 hybrid) scheduled for de novo pulmonary vein isolation. A vHPvSD ablation protocol (90 Watt (W), 4 seconds (s)) was compared to a hybrid protocol using vHPvSD on the posterior wall and 50 W HPSD (high-power short-duration) ablation guided by the Ablation Index along the remaining spots. Results: Ablation times were significantly shorter in the vHPvSD cohort (5.4 min. vs. 14.2 min, p < 0.001), thus resulting in a significant reduction in the overall procedural duration (91 min vs. 106 min, p = 0.003). The non-significant slightly higher first-pass isolation rates in the vHPvSD cohort (85% vs. 76%, p = 0.262) did not affect freedom from AF 6 months after the procedure (83% vs. 87%, p = 0.622). Conclusion: vHPvSD helps in shortening the PVI procedural duration, thus neither affecting first-pass isolation rates nor freedom from atrial tachyarrhythmia recurrence at 6 months after the index procedure. Full article
26 pages, 7088 KiB  
Article
DPCalib: Dual-Perspective View Network for LiDAR-Camera Joint Calibration
by Jinghao Cao, Xiong Yang, Sheng Liu, Tiejian Tang, Yang Li and Sidan Du
Electronics 2024, 13(10), 1914; https://doi.org/10.3390/electronics13101914 (registering DOI) - 13 May 2024
Abstract
The precise calibration of a LiDAR-camera system is a crucial prerequisite for multimodal 3D information fusion in perception systems. The accuracy and robustness of existing traditional offline calibration methods are inferior to methods based on deep learning. Meanwhile, most parameter regression-based online calibration [...] Read more.
The precise calibration of a LiDAR-camera system is a crucial prerequisite for multimodal 3D information fusion in perception systems. The accuracy and robustness of existing traditional offline calibration methods are inferior to methods based on deep learning. Meanwhile, most parameter regression-based online calibration methods directly project LiDAR data onto a specific plane, leading to information loss and perceptual limitations. A novel network, DPCalib, a dual perspective view network that mitigates the aforementioned issue, is proposed in this paper. This paper proposes a novel neural network architecture to achieve the fusion and reuse of input information. We design a feature encoder that effectively extracts features from two orthogonal views using attention mechanisms. Furthermore, we propose an effective decoder that aggregates features from two views, thereby obtaining accurate extrinsic parameter estimation outputs. The experimental results demonstrate that our approach outperforms existing SOTA methods, and the ablation experiments validate the rationality and effectiveness of our work. Full article
20 pages, 2733 KiB  
Article
Flexural Capacity of the Normal Sections of Concrete Beams Strengthened with Corrugated Steel Plates
by Xianda Feng, Dejun Liu, Xiao Long, Kang Duan, Jianping Zuo, Wei Liu and Haiyang Dong
Buildings 2024, 14(5), 1398; https://doi.org/10.3390/buildings14051398 (registering DOI) - 13 May 2024
Abstract
To explore the law of load-carrying performance enhancement of concrete beams reinforced with corrugated steel plates (CSPs), three groups of controlled bending tests were conducted on five beam specimens. The load-bearing capacity of concrete members commensurately increased with the thickness of reinforcing flat [...] Read more.
To explore the law of load-carrying performance enhancement of concrete beams reinforced with corrugated steel plates (CSPs), three groups of controlled bending tests were conducted on five beam specimens. The load-bearing capacity of concrete members commensurately increased with the thickness of reinforcing flat and corrugated steel plates. Additionally, for the same amount of steel, the load-bearing capacity of concrete beams improved more with CSP reinforcement than with reinforcement with flat steel plates. Accordingly, a theoretical formula for the moment of inertia of the combined section of a CSP-reinforced concrete beam was derived. Comparison verification showed that the calculation results for the beams reinforced with CSPs of different thicknesses were highly accurate. Finally, based on the damage mode of the CSP-reinforced concrete beam specimens, a formula for calculating the flexural bearing capacity of the positive cross-section of the beam with corrugated steel reinforcement was established. The calculated values agreed with the experimental values, which validated the flexural load capacity theory pertaining to positive sections and the flexural capacity model for reinforced beams. Full article
(This article belongs to the Section Building Structures)
22 pages, 4662 KiB  
Article
DReAmocracy: A Method to Capitalise on Prior Drug Discovery Efforts to Highlight Candidate Drugs for Repurposing
by Kyriaki Savva, Margarita Zachariou, Marilena M. Bourdakou, Nikolas Dietis and George M. Spyrou
Int. J. Mol. Sci. 2024, 25(10), 5319; https://doi.org/10.3390/ijms25105319 (registering DOI) - 13 May 2024
Abstract
In the area of drug research, several computational drug repurposing studies have highlighted candidate repurposed drugs, as well as clinical trial studies that have tested/are testing drugs in different phases. To the best of our knowledge, the aggregation of the proposed lists of [...] Read more.
In the area of drug research, several computational drug repurposing studies have highlighted candidate repurposed drugs, as well as clinical trial studies that have tested/are testing drugs in different phases. To the best of our knowledge, the aggregation of the proposed lists of drugs by previous studies has not been extensively exploited towards generating a dynamic reference matrix with enhanced resolution. To fill this knowledge gap, we performed weight-modulated majority voting of the modes of action, initial indications and targeted pathways of the drugs in a well-known repository, namely the Drug Repurposing Hub. Our method, DReAmocracy, exploits this pile of information and creates frequency tables and, finally, a disease suitability score for each drug from the selected library. As a testbed, we applied this method to a group of neurodegenerative diseases (Alzheimer’s, Parkinson’s, Huntington’s disease and Multiple Sclerosis). A super-reference table with drug suitability scores has been created for all four neurodegenerative diseases and can be queried for any drug candidate against them. Top-scored drugs for Alzheimer’s Disease include agomelatine, mirtazapine and vortioxetine; for Parkinson’s Disease, they include apomorphine, pramipexole and lisuride; for Huntington’s, they include chlorpromazine, fluphenazine and perphenazine; and for Multiple Sclerosis, they include zonisamide, disopyramide and priralfimide. Overall, DReAmocracy is a methodology that focuses on leveraging the existing drug-related experimental and/or computational knowledge rather than a predictive model for drug repurposing, offering a quantified aggregation of existing drug discovery results to (1) reveal trends in selected tracks of drug discovery research with increased resolution that includes modes of action, targeted pathways and initial indications for the investigated drugs and (2) score new candidate drugs for repurposing against a selected disease. Full article
(This article belongs to the Special Issue From Molecular Insights to Novel Therapies: Neurological Diseases)
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15 pages, 4526 KiB  
Article
Effect of Nanohydroxyapatite on Silk Fibroin–Chitosan Interactions—Molecular Dynamics Study
by Maciej Przybyłek, Anna Tuwalska, Damian Ledziński, Sandra Śmigiel, Alina Sionkowska, Iwona Białas and Piotr Bełdowski
Appl. Sci. 2024, 14(10), 4131; https://doi.org/10.3390/app14104131 (registering DOI) - 13 May 2024
Abstract
Fibroin–chitosan composites, especially those containing nanohydroxyapatite, show potential for bone tissue regeneration. The physicochemical properties of these biocomposites depend on the compatibility between their components. In this study, the intermolecular interactions of fibroin and chitosan were analyzed using a molecular dynamics approach. Two [...] Read more.
Fibroin–chitosan composites, especially those containing nanohydroxyapatite, show potential for bone tissue regeneration. The physicochemical properties of these biocomposites depend on the compatibility between their components. In this study, the intermolecular interactions of fibroin and chitosan were analyzed using a molecular dynamics approach. Two types of systems were investigated: one containing acetic acid and the other containing calcium (Ca2+) and hydrogen phosphate (HPO₄2−) ions mimicking hydroxyapatite conditions. After obtaining the optimal equilibrium structures, the distributions of several types of interactions, including hydrogen bonds, ionic contacts, and hydrophobic contacts, along with structural and energetical features, were examined. The calculated binding energy values for the fibroin–chitosan complexes confirm their remarkable stability. The high affinity of fibroin for chitosan can be explained by the formation of a dense network of interactions between the considered biopolymers. These interactions were found to primarily be hydrogen bonds and ionic contacts involving ALA, ARG, ASN, ASP, GLN, GLU, GLY, LEU, PRO, SER, THR, TYR, and VAL residues. As established, the complexation of fibroin with chitosan maintains the β-sheet conformation of the peptide. β-Sheet fragments in fibroin are involved in the formation of a significant number of hydrogen bonds and ionic contacts with chitosan. Full article
(This article belongs to the Section Chemical and Molecular Sciences)
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20 pages, 2064 KiB  
Article
Photocatalytic Degradation of Quinolones by Magnetic MOFs Materials and Mechanism Study
by Hongchao Chang, Guangyao Xu, Xiantong Huang, Wei Xu, Fujuan Luo, Jiarong Zang, Xiaowei Lin, Rong Huang, Hua Yu and Binbin Yu
Molecules 2024, 29(10), 2294; https://doi.org/10.3390/molecules29102294 (registering DOI) - 13 May 2024
Abstract
With the rising incidence of various diseases in China and the constant development of the pharmaceutical industry, there is a growing demand for floxacin-type antibiotics. Due to the large-scale production and high cost of waste treatment, the parent drug and its metabolites constantly [...] Read more.
With the rising incidence of various diseases in China and the constant development of the pharmaceutical industry, there is a growing demand for floxacin-type antibiotics. Due to the large-scale production and high cost of waste treatment, the parent drug and its metabolites constantly enter the water environment through domestic sewage, production wastewater, and other pathways. In recent years, the pollution of the aquatic environment by floxacin has become increasingly serious, making the technology to degrade floxacin in the aquatic environment a research hotspot in the field of environmental science. Metal–organic frameworks (MOFs), as a new type of porous material, have attracted much attention in recent years. In this paper, four photocatalytic materials, MIL-53(Fe), NH2-MIL-53(Fe), MIL-100(Fe), and g-C3N4, were synthesised and applied to the study of the removal of ofloxacin and enrofloxacin. Among them, the MIL-100(Fe) material exhibited the best photocatalytic effect. The degradation efficiency of ofloxacin reached 95.1% after 3 h under visible light, while enrofloxacin was basically completely degraded. The effects of different materials on the visible photocatalytic degradation of the floxacin were investigated. Furthermore, the photocatalytic mechanism of enrofloxacin and ofloxacin was revealed by the use of three trappers (®O2, h+, and ®OH), demonstrating that the role of ®O2 promoted the degradation effect of the materials under photocatalysis. Full article
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29 pages, 5543 KiB  
Article
Spatiotemporal Patterns of White Matter Maturation after Pre-Adolescence: A Diffusion Kurtosis Imaging Study
by Ezequiel Farrher, Farida Grinberg, Tamara Khechiashvili, Irene Neuner, Kerstin Konrad and N. Jon Shah
Brain Sci. 2024, 14(5), 495; https://doi.org/10.3390/brainsci14050495 (registering DOI) - 13 May 2024
Abstract
Diffusion tensor imaging (DTI) enables the assessment of changes in brain tissue microstructure during maturation and ageing. In general, patterns of cerebral maturation and decline render non-monotonic lifespan trajectories of DTI metrics with age, and, importantly, the rate of microstructural changes is heterochronous [...] Read more.
Diffusion tensor imaging (DTI) enables the assessment of changes in brain tissue microstructure during maturation and ageing. In general, patterns of cerebral maturation and decline render non-monotonic lifespan trajectories of DTI metrics with age, and, importantly, the rate of microstructural changes is heterochronous for various white matter fibres. Recent studies have demonstrated that diffusion kurtosis imaging (DKI) metrics are more sensitive to microstructural changes during ageing compared to those of DTI. In a previous work, we demonstrated that the Cohen’s d of mean diffusional kurtosis (dMK) represents a useful biomarker for quantifying maturation heterochronicity. However, some inferences on the maturation grades of different fibre types, such as association, projection, and commissural, were of a preliminary nature due to the insufficient number of fibres considered. Hence, the purpose of this follow-up work was to further explore the heterochronicity of microstructural maturation between pre-adolescence and middle adulthood based on DTI and DKI metrics. Using the effect size of the between-group parametric changes and Cohen’s d, we observed that all commissural fibres achieved the highest level of maturity, followed by the majority of projection fibres, while the majority of association fibres were the least matured. We also demonstrated that dMK strongly correlates with the maxima or minima of the lifespan curves of DTI metrics. Furthermore, our results provide substantial evidence for the existence of spatial gradients in the timing of white matter maturation. In conclusion, our data suggest that DKI provides useful biomarkers for the investigation of maturation spatial heterogeneity and heterochronicity. Full article
(This article belongs to the Section Neurotechnology and Neuroimaging)
14 pages, 461 KiB  
Article
Trends and Characteristics of Brown Rice Consumption among Adults in Japan: An Analysis of the National Health and Nutrition Surveys, 2012–2019
by Nayu Ikeda, Miwa Yamaguchi and Nobuo Nishi
Nutrients 2024, 16(10), 1473; https://doi.org/10.3390/nu16101473 (registering DOI) - 13 May 2024
Abstract
Brown rice is a familiar whole grain in Japan. We examined national trends in brown rice consumption among Japanese adults aged ≥20 years old, using individual-level data from the National Health and Nutrition Surveys conducted between 2012 and 2019. We employed multivariable logistic [...] Read more.
Brown rice is a familiar whole grain in Japan. We examined national trends in brown rice consumption among Japanese adults aged ≥20 years old, using individual-level data from the National Health and Nutrition Surveys conducted between 2012 and 2019. We employed multivariable logistic regression to identify factors associated with brown rice consumption. The 95th percentile of daily brown rice intake remained at 0.0 g throughout the study period. The percentage of brown rice consumers increased from 1.8% (95% confidence interval: 1.6–2.1) in 2012 to 2.6% (95% confidence interval: 2.0–3.4) in 2019. Compared with individuals who consumed only white rice, brown rice consumers had significantly higher mean intake levels of macronutrients, legumes, vegetables, fruits, and nuts. Brown rice consumption was positively associated with certain sociodemographic characteristics (being female, older age, residing in a major city, living without very young children, and having higher education levels) and health behaviors (lower body mass index, engaging in regular exercise, and being a former or never smoker). Despite its potential nutritional benefits in balanced diets, only a small fraction of adults in Japan consume brown rice, indicating a need for further promotion, particularly among individuals with characteristics associated with brown rice consumption. Full article
(This article belongs to the Special Issue Effects of Whole Grain and Dietary Fiber on Cardiometabolic Health)
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26 pages, 1218 KiB  
Article
Impact of the Local Dynamics on Exit Choice Behaviour in Evacuation Model
by Sensen Xing, Cheng Wang, Dongli Gao, Wei Wang, Anthony Chun Yin Yuen, Eric Wai Ming Lee, Guan Heng Yeoh and Qing Nian Chan
Fire 2024, 7(5), 167; https://doi.org/10.3390/fire7050167 - 13 May 2024
Abstract
This study investigated the interplay between exit selection models and local pedestrian movement patterns within floor field frameworks. Specifically, this investigation analysed the performance of a multinomial logit exit choice model, incorporating both expected utility theory and cumulative prospect theory frameworks when coupled [...] Read more.
This study investigated the interplay between exit selection models and local pedestrian movement patterns within floor field frameworks. Specifically, this investigation analysed the performance of a multinomial logit exit choice model, incorporating both expected utility theory and cumulative prospect theory frameworks when coupled with three distinct local-level pedestrian movement models (FF-Von Neumann, FF-Moore, and NSFF). The expected utility theory framework considers the deterministic component as a linear relationship, while the cumulative prospect theory framework further considers the decision-maker’s risky attitudes by transforming objective terms into subjective terms using a power value function. The core objective was to comprehend how local movement dynamics, as represented by the floor field models, influence decision-making during exit selection. Comparative analyses revealed intriguing variations between the three local models, despite their shared expected utility theory-based exit choice framework. These discrepancies stemmed from the diverse pedestrian trajectory behaviours generated by each model. Consequently, these local dynamics impacted the decision-maker’s assessment of critical factors, such as the number of evacuees close to the decision-maker (NCDM) and the number of evacuees close to an exit (NCE), which the exit choice model incorporates. These assessments, in turn, significantly affected higher-level decision-making. The integration of the three models with the multinomial logit exit choice model, using either cumulative prospect theory and expected utility theory frameworks, further strengthened the observed bilateral relationship. While the specific nature of this relationship varied depending on the chosen framework and its implementation details, these consistent findings demonstrate the robustness of the results. This reinforced the influence of local-level pedestrian dynamics on higher-level exit selection, highlighting the importance of accurate crowd dynamics modelling, especially when advanced exit choice models consider local movement factors. Full article
(This article belongs to the Special Issue Ensuring Safety against Fires in Overcrowded Urban Areas)
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21 pages, 1216 KiB  
Article
Permeabilities of Water–Oil Two-Phase Flow in Capillary Fractures with Different Wettabilities
by Na Huang, Lei Liu, Heng Chen and Yanyan Huang
Energies 2024, 17(10), 2353; https://doi.org/10.3390/en17102353 (registering DOI) - 13 May 2024
Abstract
The influence of wettability on the permeability performance of water–oil two-phase flow has attracted increasing attention. Dispersed flow and stratified flow are two flow regimes for water–oil two-phase flow in capillary fractures. The theoretical models of relative permeability considering wettability were developed for [...] Read more.
The influence of wettability on the permeability performance of water–oil two-phase flow has attracted increasing attention. Dispersed flow and stratified flow are two flow regimes for water–oil two-phase flow in capillary fractures. The theoretical models of relative permeability considering wettability were developed for these two water–oil flow regimes from the momentum equations of the two-fluid model. Wettability coefficients were proposed to study the impact of wettability on relative permeabilities. Experiments were conducted to study the relative permeabilities of laminar water–oil two-phase flow in water-saturated and oil-saturated horizontal capillary fractures with different hydraulic diameters. These fractures were made of polymethylmethacrylate (PMMA) and polytetrafluoroethylene (PTFE), which had different surface wettabilities. In this experiment, the regimes are dispersed flow and stratified flow. The results show that the effect of wettability on the relative permeabilities increases as the hydraulic diameters of capillary fractures decrease for water–oil two-phase flow. The relative permeabilities in a water-saturated capillary fracture are higher than those in an oil-saturated capillary fracture of the same material. The relative permeabilities in a PTFE capillary fracture are larger than those in a PMMA capillary fracture under the same saturated condition. Wettability has little effect on the permeability performances of water–oil two-phase flow in water-saturated capillary fractures, but is significant for those in oil-saturated capillary fractures. Full article
(This article belongs to the Section H1: Petroleum Engineering)
14 pages, 18071 KiB  
Article
Robust Radar Inertial Odometry in Dynamic 3D Environments
by Yang Lyu, Lin Hua, Jiaming Wu, Xinkai Liang and Chunhui Zhao
Drones 2024, 8(5), 197; https://doi.org/10.3390/drones8050197 - 13 May 2024
Abstract
Millimeter-Wave Radar is one promising sensor to achieve robust perception against challenging observing conditions. In this paper, we propose a Radar Inertial Odometry (RIO) pipeline utilizing a long-range 4D millimeter-wave radar for autonomous vehicle navigation. Initially, we develop a perception frontend based on [...] Read more.
Millimeter-Wave Radar is one promising sensor to achieve robust perception against challenging observing conditions. In this paper, we propose a Radar Inertial Odometry (RIO) pipeline utilizing a long-range 4D millimeter-wave radar for autonomous vehicle navigation. Initially, we develop a perception frontend based on radar point cloud filtering and registration to estimate the relative transformations between frames reliably. Then an optimization-based backbone is formulated, which fuses IMU data, relative poses, and point cloud velocities from radar Doppler measurements. The proposed method is extensively tested in challenging on-road environments and in-the-air environments. The results indicate that the proposed RIO can provide a reliable localization function for mobile platforms, such as automotive vehicles and Unmanned Aerial Vehicles (UAVs), in various operation conditions. Full article
(This article belongs to the Special Issue UAV Positioning: From Ground to Sky)
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23 pages, 10540 KiB  
Review
Unveiling the Influential Factors and Heavy Industrial Applications of Graphene Hybrid Polymer Composites
by Zulfiqar Ali, Saba Yaqoob, Jinhong Yu and Alberto D’Amore
J. Compos. Sci. 2024, 8(5), 183; https://doi.org/10.3390/jcs8050183 - 13 May 2024
Abstract
Graphene hybrid-filler polymer composites have emerged as prominent materials that revolutionize heavy industries. This review paper encapsulates an in-depth analysis of different influential factors, such as filler/graphene type, aspect ratios, dispersion methods, filler-matrix compatibility, fiber orientation, synergistic effects, different processing techniques, and post-curing [...] Read more.
Graphene hybrid-filler polymer composites have emerged as prominent materials that revolutionize heavy industries. This review paper encapsulates an in-depth analysis of different influential factors, such as filler/graphene type, aspect ratios, dispersion methods, filler-matrix compatibility, fiber orientation, synergistic effects, different processing techniques, and post-curing conditions, which affect the processing and properties of graphene hybrid polymer composites, as well as their resultant applications. Additionally, it discusses the substantial role of graphene reinforcement with other fillers, such as carbon nanotubes, silica, nano-clays, and metal oxides, to produce functionalized hybrid polymer composites with synergistically enhanced tailored properties, offering solutions for heavy industries, including aerospace, automotive, electronics, and energy harvesting. This review concludes with some suggestions and an outlook on the future of these composite materials by emphasizing the need for continued research to fully optimize their potential. Full article
(This article belongs to the Special Issue Progress in Polymer Composites, Volume III)
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10 pages, 1045 KiB  
Article
Comparative Investigation of Thermal Properties Improvement of Nano-Enhanced Organic Phase Change Materials
by Aravindh Madhavankutty Ambika, Gopi Kannan Kalimuthu and Veerakumar Chinnasamy
J. Compos. Sci. 2024, 8(5), 182; https://doi.org/10.3390/jcs8050182 - 13 May 2024
Abstract
Thermal energy storage (TES) using phase change materials (PCMs) is one of the potential solutions for stockpiling thermal energy and utilizing it for different applications, which results in effective energy usage. The main drawback of organic PCMs in practical applications is poor heat [...] Read more.
Thermal energy storage (TES) using phase change materials (PCMs) is one of the potential solutions for stockpiling thermal energy and utilizing it for different applications, which results in effective energy usage. The main drawback of organic PCMs in practical applications is poor heat transfer due to low thermal conductivity (TC). Therefore, investigations into nano-enhanced PCMs are being explored to improve their thermophysical properties. In this work, the various thermophysical characteristics of nano-enhanced lauryl alcohol as a PCM were investigated using carbon-based and metallic nanoparticles. The results indicated that the addition of nanoparticles improved its thermal properties and affected other physical properties, such as viscosity. The latent heat was degraded with the addition of nanoparticles. The results revealed that by adding MWCNTs and CuO nanoparticles, a maximum of 82.6% and 49.6% improvement in TC was achieved, respectively. The maximum drop in latent heat during melting and freezing for the PCM with MWCNTs was about 10.1% and 9.3%, respectively, whereas for the PCM with CuO, they were about 11% and 10.3%, respectively. The lowest supercooling for the PCM with MWCNTs and CuO nanoparticles was 8.6 and 8.3 °C, respectively. The present work confirms that nano-enhanced PCMs can be a potential material for storing thermal energy for various applications. Full article
(This article belongs to the Special Issue Composites for Energy Storage Applications, Volume II)
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11 pages, 2241 KiB  
Article
Toxicity, Oxidative Stress, and Tissue Distribution of Butachlor in the Juvenile Chinese Mitten Crab (Eriocheir sinensis)
by Song Wu, Peng Wang, Ying Zhang, Li Huang, Qirui Hao, Lei Gao, Dongli Qin and Xiaoli Huang
Fishes 2024, 9(5), 177; https://doi.org/10.3390/fishes9050177 - 13 May 2024
Abstract
The Chinese mitten crab (Eriocheir sinensis) is one of the most commercially important crustacean species in China. The aim of this study was to characterize the toxic effects of butachlor (an herbicide of the acetanilide class) on juvenile E. sinensis crabs. [...] Read more.
The Chinese mitten crab (Eriocheir sinensis) is one of the most commercially important crustacean species in China. The aim of this study was to characterize the toxic effects of butachlor (an herbicide of the acetanilide class) on juvenile E. sinensis crabs. The lethal effects and the acute toxicity of butachlor on juvenile E. sinensis specimens were assessed through a semi-static in vitro experiment. We determined the activities of superoxide dismutase (SOD) and catalase (CAT) as well as the levels of glutathione (GSH) and malondialdehyde (MDA) in the gills and the hepatopancreas of the juvenile crabs, at different time points over a 14-day short-term exposure to butachlor. Moreover, we measured the residual levels of butachlor in three different tissues (gills, hepatopancreas, and muscles) of the juvenile crabs over a longer period. Our findings revealed that butachlor is highly toxic for juvenile E. sinensis crabs. In fact, the median lethal concentration (LC50) values of butachlor at 24, 48, 72, and 96 h were found to be 4.22, 1.84, 0.34, and 0.14 mg/L, respectively, while the safe concentration was 0.014 mg/L. The antioxidant defense ability of the juvenile E. sinensis crabs against butachlor was induced after exposure to the herbicide at a concentration of 0.01 mg/L. After 14 days of exposure to butachlor at 0.04 and 0.16 mg/L, both SOD and CAT were found to be significantly inhibited (p < 0.05), the GSH levels were found to be significantly decreased (p < 0.05) and the MDA levels were identified as significantly increased (p < 0.05). Moreover, after 14 days of exposure to butachlor at 0.16 mg/L, the activities of SOD and CAT as well as the content of GSH in the hepatopancreas were found to be significantly decreased (p < 0.05). Our results revealed that a high concentration of butachlor was capable of inducing oxidative stress and damage in juvenile E. sinensis crabs. The maximal residual value of butachlor was obtained in the gills, with a content of 4.56 μg/kg. Butachlor was not detected after 24 days in the aforementioned three tissues of the juvenile crabs, thereby indicating that it was effectively metabolized. Full article
(This article belongs to the Special Issue Advances in Crab Fisheries)
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3 pages, 147 KiB  
Editorial
Effect of Dietary Supplementation on the Growth and Immunity of Fish and Shellfish
by Changle Qi, Qiyou Xu, Jianhua Ming, Fei Song and Chuanpeng Zhou
Fishes 2024, 9(5), 176; https://doi.org/10.3390/fishes9050176 - 13 May 2024
Abstract
With the rapid development of aquaculture, the shortage of high-quality dietary ingredients has become a critical problem limiting the sustainable development of aquaculture [...] Full article
18 pages, 293 KiB  
Article
Navigating Real Estate Investment Trust Performance Dynamics: The Role of Style (Equity vs. Mortgage Real Estate Investment Trusts) and Diversification Amidst the COVID-19 Pandemic
by Ankita Damani, Anh Tuan Nguyen and FNU Pratima
J. Risk Financial Manag. 2024, 17(5), 202; https://doi.org/10.3390/jrfm17050202 - 13 May 2024
Abstract
In this paper, we investigate the impact of COVID-19 on different performance measures and the risk of US Real Estate Investment Trusts (REITs) with different styles. Our findings suggest a phenomenon with compelling evidence of reduced performance without any significant changes in risk [...] Read more.
In this paper, we investigate the impact of COVID-19 on different performance measures and the risk of US Real Estate Investment Trusts (REITs) with different styles. Our findings suggest a phenomenon with compelling evidence of reduced performance without any significant changes in risk profile amidst the COVID-19 pandemic. Particularly, mortgage REITs (MREITs) appear to be more adversely affected compared to equity REITs (EREITs). We further explore and analyze the performance of specialized REITs in contrast to diversified REITs in the distinctive conditions presented by COVID-19. We find that diversification creates value for the entire sample period, whereas, during the COVID-19 pandemic, property type specialization helps, although the results are weakly significant. The findings on risk suggest investors’ short-run outlook on market reaction. These results remain robust to additional tests. The implications provide insight for investors as a reference to reallocate assets in their portfolios during uncertain times. Full article
(This article belongs to the Special Issue Realizing Economic Diversification from Diverse Economic Perspectives)
9 pages, 563 KiB  
Article
Globalisation of Professional Sport Finance
by Wladimir Andreff
J. Risk Financial Manag. 2024, 17(5), 201; https://doi.org/10.3390/jrfm17050201 - 13 May 2024
Abstract
The objective of the present paper is to put a milestone on the roadmap toward a global economic system of professional sport, at least as regards its financial dimension, i.e., its model of finance, its ownership, and some new trends in global sport [...] Read more.
The objective of the present paper is to put a milestone on the roadmap toward a global economic system of professional sport, at least as regards its financial dimension, i.e., its model of finance, its ownership, and some new trends in global sport finance. Professional sport went through a radical change during the 1990s when switching from gate receipts to TV rights revenues as its major source of finance and from local/domestic to internationalised/globalised sources of revenue. This change was more marked in European soccer (football) before spreading throughout other professional sport disciplines. In fact, the whole distribution of sport financing was restructured as shown in this paper. Starting from this evidence of the first stage of sport finance globalisation, it appears that new transformations have been at work in sport finance more recently. In particular, soccer moved from globalisation of flows (revenues, finance) to asset globalisation in terms of club ownership. At last, this paper discusses the emergence of new trends in global sport finance such as treating professional (soccer) players as financial assets and crypto-assets penetrating the sports business. Full article
(This article belongs to the Special Issue Globalization and Economic Integration)
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13 pages, 245 KiB  
Article
Evaluating the Efficacy of a Peripheral Nerve Simulator-Guided Brachial Plexus Block in Rabbits Undergoing Orthopaedic Surgery Compared to Systemic Analgesia
by Sophie A. Mead, Matthew J. Allen, Sara Ahmed Hassouna Elsayed and Claudia S. Gittel
Vet. Sci. 2024, 11(5), 213; https://doi.org/10.3390/vetsci11050213 - 13 May 2024
Abstract
Locoregional anaesthetic techniques are invaluable for providing multimodal analgesia for painful surgical procedures. This prospective, randomised study describes a nerve stimulator-guided brachial plexus blockade (BPB) in rabbits undergoing orthopaedic surgery in comparison to systemic lidocaine. Premedication was provided with intramuscular (IM) medetomidine, fentanyl, [...] Read more.
Locoregional anaesthetic techniques are invaluable for providing multimodal analgesia for painful surgical procedures. This prospective, randomised study describes a nerve stimulator-guided brachial plexus blockade (BPB) in rabbits undergoing orthopaedic surgery in comparison to systemic lidocaine. Premedication was provided with intramuscular (IM) medetomidine, fentanyl, and midazolam. Anaesthesia was induced (propofol IV) and maintained with isoflurane. Nine rabbits received a lidocaine BPB (2%; 0.3 mL kg−1), and eight received a lidocaine constant rate infusion (CRI) (2 mg kg−1 IV, followed by 100 µg kg−1 min−1). Rescue analgesia was provided with fentanyl IV. Carprofen was administered at the end of the surgery. Postoperative pain was determined using the Rabbit Grimace Scale (RGS) and a composite pain scale. Buprenorphine was administered according to the pain score for two hours after extubation. Rabbits were filmed during the first two hours to measure distance travelled and behaviours. Food intake and faeces output were compared. Every rabbit in CRI required intraoperative rescue analgesia compared to none in BPB. However, rabbits in both groups had similar pain scores, and there was no difference in the administration of postoperative analgesia. There were no significant differences in food intake or faeces production over 18 h, and no significant differences in distance travelled or behaviours examined during the first two hours. BPB seems superior for intraoperative analgesia. Postoperatively, both groups were comparable. Full article
(This article belongs to the Special Issue Anesthesia and Pain Management in Veterinary Surgery)

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