The 2023 MDPI Annual Report has
been released!
 
20 pages, 739 KiB  
Review
Research Progress in the Separation of Chemical Components from Essential Oils by High-Speed Countercurrent Chromatography
by Linhong He, Zihao Zhong, Lijuan Zhang and Xi Bai
Separations 2024, 11(5), 152; https://doi.org/10.3390/separations11050152 (registering DOI) - 15 May 2024
Abstract
Essential oils (EOs) are vital secondary metabolites in plants. They have garnered substantial attention owing to their distinct flavors and desirable attributes, including potent antioxidant, antibacterial, and antitumor properties. Nevertheless, the active constituents of EOs exhibit intricate chemical structures, and conventional separation techniques [...] Read more.
Essential oils (EOs) are vital secondary metabolites in plants. They have garnered substantial attention owing to their distinct flavors and desirable attributes, including potent antioxidant, antibacterial, and antitumor properties. Nevertheless, the active constituents of EOs exhibit intricate chemical structures, and conventional separation techniques are inadequate for purifying the individual chemical components from EOs. High-speed countercurrent chromatography, based on the principles of a hydrodynamic equilibrium system, has emerged as a liquid–liquid chromatographic separation method renowned for its ability to handle substantial single injection volumes and the absence of irreversible adsorption. Consequently, in recent years, this technique has been widely employed in the isolation and refinement of natural products. In this review, a comprehensive analysis is conducted, contrasting the merits and demerits of high-speed countercurrent chromatography with conventional separation methods. The solvent systems, elution modes, commonly employed detectors, and practical applications are reviewed in the context of high-speed countercurrent chromatography for essential oil separation and purification. Furthermore, this review offers a glimpse into the potential prospects of applying this technique, with the intention of serving as a valuable reference for the use of high-speed countercurrent chromatography in the purification of EOs. Full article
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15 pages, 9807 KiB  
Article
Investigation of the Tribological Properties of Hybrid Additive-Modified Water-Based Lubricating Fluid
by Raimondas Kreivaitis, Jolanta Treinytė, Artūras Kupčinskas, Milda Gumbytė and Eglė Sendžikienė
Lubricants 2024, 12(5), 178; https://doi.org/10.3390/lubricants12050178 (registering DOI) - 15 May 2024
Abstract
Water-based lubricating fluids (WBLFs), known for their significant environmental benefits, are the focus of this study. The properties of WBLFs directly influence lubricated mechanisms’ longevity and operating efficiency. WBLFs are enhanced using additives, which must improve their properties and, at the same time, [...] Read more.
Water-based lubricating fluids (WBLFs), known for their significant environmental benefits, are the focus of this study. The properties of WBLFs directly influence lubricated mechanisms’ longevity and operating efficiency. WBLFs are enhanced using additives, which must improve their properties and, at the same time, remain environmentally friendly. This study combines bis(2-hydroxyethyl) ammonium erucate protic ionic liquid and titanium oxide nanoparticles to formulate the hybrid additive. The lubricity was investigated using Alumina/Bearing steel and WC/Bearing steel friction pairs in a reciprocating ball-on-plate tribo-tester. The results show that protic ionic liquid can significantly improve lubricity and the corrosion-preventing ability of the base fluid. Applying a hybrid additive further improved the wear reduction ability in the WC/Bearing steel friction pair. However, the wear reduction ability was diminished when a hybrid additive was used to lubricate the Alumina/Bearing steel friction pair. The proposed lubricity improvement mechanism is based on forming an adsorption layer of ionic liquid molecules and rolling and tribo-sintering titanium oxide nanoparticles. Full article
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13 pages, 6417 KiB  
Article
Preparation and Application of High Internal Phase Pickering Emulsion Gels Stabilized by Starch Nanocrystal/Tannic Acid Complex Particles
by Haoran Jin, Chen Li, Yajuan Sun, Bingtian Zhao and Yunxing Li
Gels 2024, 10(5), 335; https://doi.org/10.3390/gels10050335 (registering DOI) - 15 May 2024
Abstract
Herein, the starch nanocrystal/tannic acid (ST) complex particles, which were prepared based on the hydrogen bond between starch nanocrystal (SNC) and tannic acid (TA), were successfully used to stabilize the HIPPE gels. The optimal TA concentration of the ST complex particles resulted in [...] Read more.
Herein, the starch nanocrystal/tannic acid (ST) complex particles, which were prepared based on the hydrogen bond between starch nanocrystal (SNC) and tannic acid (TA), were successfully used to stabilize the HIPPE gels. The optimal TA concentration of the ST complex particles resulted in better water dispersibility, surface wettability, and interfacial activity as compared to SNC. The hydrogen bond responsible for the formation of ST complex particles and subsequent stable emulsions was demonstrated by varying the pH and ionic strength of the aqueous phase. Notably, the HIPPE gels stabilized via the ST complex particles can maintain long-term stability for up to three months. The HIPPEs stabilized via the ST complex particles all displayed gel-like features and had smaller droplets and denser droplet networks than the SNC-stabilized HIPPEs. The rheological behavior of HIPPE gels stabilized via the ST complex particles can be readily changed by tuning the mass ratio of SNC and TA as well as pH. Finally, the prepared HIPPE gels used to effectively protect encapsulated β-carotene against high temperatures and ultraviolet radiation and its controllable release at room temperature were demonstrated. It is anticipated that the aforementioned findings will provide new perspectives on the preparation of Pickering emulsion for delivery systems. Full article
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11 pages, 2004 KiB  
Article
Nobiletin Stimulates Adrenal Hormones and Modulates the Circadian Clock in Mice
by Conn Ryan, Yu Tahara, Atsushi Haraguchi, Yuanyuan Lu and Shigenobu Shibata
Nutrients 2024, 16(10), 1491; https://doi.org/10.3390/nu16101491 (registering DOI) - 15 May 2024
Abstract
Polymethoxyflavonoids, such as nobiletin (abundant in Citrus depressa), have been reported to have antioxidant, anti-inflammatory, anticancer, and anti-dementia effects, and are also a circadian clock modulator through retinoic acid receptor-related orphan receptor (ROR) α/γ. However, the optimal timing of nobiletin intake has not [...] Read more.
Polymethoxyflavonoids, such as nobiletin (abundant in Citrus depressa), have been reported to have antioxidant, anti-inflammatory, anticancer, and anti-dementia effects, and are also a circadian clock modulator through retinoic acid receptor-related orphan receptor (ROR) α/γ. However, the optimal timing of nobiletin intake has not yet been determined. Here, we explored the time-dependent treatment effects of nobiletin and a possible novel mechanistic idea for nobiletin-induced circadian clock regulation in mice. In vivo imaging showed that the PER2::LUC rhythm in the peripheral organs was altered in accordance with the timing of nobiletin administration (100 mg/kg). Administration at ZT4 (middle of the light period) caused an advance in the peripheral clock, whereas administration at ZT16 (middle of the dark period) caused an increase in amplitude. In addition, the intraperitoneal injection of nobiletin significantly and potently stimulated corticosterone and adrenaline secretion and caused an increase in Per1 expression in the peripheral tissues. Nobiletin inhibited phosphodiesterase (PDE) 4A1A, 4B1, and 10A2. Nobiletin or rolipram (PDE4 inhibitor) injection, but not SR1078 (RORα/γ agonist), caused acute Per1 expression in the peripheral tissues. Thus, the present study demonstrated a novel function of nobiletin and the regulation of the peripheral circadian clock. Full article
(This article belongs to the Section Micronutrients and Human Health)
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19 pages, 2300 KiB  
Review
The Stria Vascularis: Renewed Attention on a Key Player in Age-Related Hearing Loss
by Sonny Bovee, Georg M. Klump, Christine Köppl and Sonja J. Pyott
Int. J. Mol. Sci. 2024, 25(10), 5391; https://doi.org/10.3390/ijms25105391 (registering DOI) - 15 May 2024
Abstract
Age-related hearing loss (HL), or presbycusis, is a complex and heterogeneous condition, affecting a significant portion of older adults and involving various interacting mechanisms. Metabolic presbycusis, a type of age-related HL, is characterized by the dysfunction of the stria vascularis, which is crucial [...] Read more.
Age-related hearing loss (HL), or presbycusis, is a complex and heterogeneous condition, affecting a significant portion of older adults and involving various interacting mechanisms. Metabolic presbycusis, a type of age-related HL, is characterized by the dysfunction of the stria vascularis, which is crucial for maintaining the endocochlear potential necessary for hearing. Although attention on metabolic presbycusis has waned in recent years, research continues to identify strial pathology as a key factor in age-related HL. This narrative review integrates past and recent research, bridging findings from animal models and human studies, to examine the contributions of the stria vascularis to age-related HL. It provides a brief overview of the structure and function of the stria vascularis and then examines mechanisms contributing to age-related strial dysfunction, including altered ion transport, changes in pigmentation, inflammatory responses, and vascular atrophy. Importantly, this review outlines the contribution of metabolic mechanisms to age-related HL, highlighting areas for future research. It emphasizes the complex interdependence of metabolic and sensorineural mechanisms in the pathology of age-related HL and highlights the importance of animal models in understanding the underlying mechanisms. The comprehensive and mechanistic investigation of all factors contributing to age-related HL, including cochlear metabolic dysfunction, remains crucial to identifying the underlying mechanisms and developing personalized, protective, and restorative treatments. Full article
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12 pages, 2987 KiB  
Article
Hourglass Magnetic Field of a Protostellar System
by Shantanu Basu, Xiyuan Li and Gianfranco Bino
Universe 2024, 10(5), 218; https://doi.org/10.3390/universe10050218 (registering DOI) - 15 May 2024
Abstract
An hourglass-shaped magnetic field pattern arises naturally from the gravitational collapse of a star-forming gas cloud. Most studies have focused on the prestellar collapse phase, when the structure has a smooth and monotonic radial profile. However, most observations target dense clouds that already [...] Read more.
An hourglass-shaped magnetic field pattern arises naturally from the gravitational collapse of a star-forming gas cloud. Most studies have focused on the prestellar collapse phase, when the structure has a smooth and monotonic radial profile. However, most observations target dense clouds that already contain a central protostar, and possibly a circumstellar disk. We utilize an analytic treatment of the magnetic field along with insights gained from simulations to develop a more realistic magnetic field model for the protostellar phase. Key elements of the model are a strong radial magnetic field in the region of rapid collapse, an off-center peak in the magnetic field strength (a consequence of magnetic field dissipation in the circumstellar disk), and a strong toroidal field that is generated in the region of rapid collapse and outflow generation. A model with a highly pinched and twisted magnetic field pattern in the inner collapse zone facilitates the interpretation of magnetic field patterns observed in protostellar clouds. Full article
(This article belongs to the Special Issue Advances in Star Formation in the Milky Way)
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18 pages, 342 KiB  
Article
Effects of the Addition of Trichoderma reesei Cellulase to Broiler Chicken Diets for a 21-Day Period
by Francisco dos Santos Perim, Weslane Justina da Silva, Dênia Oliveira de Souza, Cirano José Ulhoa, Camila Ferreira Rezende, Ludmilla Faria dos Santos, Fabiana Ramos dos Santos, Fabiano Guimarães Silva and Cibele Silva Minafra
Animals 2024, 14(10), 1467; https://doi.org/10.3390/ani14101467 (registering DOI) - 15 May 2024
Abstract
The cellulose present in the cell wall of vegetables prevents the greater release of nutrients to the animal. Therefore, the use of the cellulase enzyme is a viable strategy as it is capable of breaking cellulose bonds, releasing nutrients such as glucose, increasing [...] Read more.
The cellulose present in the cell wall of vegetables prevents the greater release of nutrients to the animal. Therefore, the use of the cellulase enzyme is a viable strategy as it is capable of breaking cellulose bonds, releasing nutrients such as glucose, increasing dietary energy, and thus improving the productive performance of birds. Trichoderma reesei is efficient in the production of cellulase, which is produced via submerged fermentation followed by purification, formulation, and drying. Therefore, an experiment was carried out using 240 male broilers of the Cobb-500® lineage to verify the effects resulting from the addition of powdered (500 g/t and 1000 g/t) and liquid (500 mL/t) cellulase over a period of 1 to 21 days. A completely randomized experimental design was used, consisting of four treatments with six replications and ten birds per replication that were housed in an experimental cage. It was observed that performance and digestibility results were significantly different with cellulase supplementation. Also, the relative weight of the large intestine in the period between one and seven days increased when cellulase was added at 1000 g/t. In the period of between eight and 14 days of life, the birds that consumed only the basal diet obtained higher levels of liver protein than those that received the treatments with the addition of the enzyme. However, 15 and 21 days, the consumed feed effect did not occur between thus, it is not conclusive whether hepatotoxicity occurs with the addition of cellulase. For the blood parameters, at 21 days, the diets with added cellulase were not significantly different regarding electrolytes. It was concluded that this cellulase produced by Trichoderma reesei can be included in the animals’ diet. Full article
(This article belongs to the Collection Sustainable Animal Nutrition and Feeding)
24 pages, 10127 KiB  
Article
Unveiling AI-Generated Financial Text: A Computational Approach Using Natural Language Processing and Generative Artificial Intelligence
by Muhammad Asad Arshed, Ștefan Cristian Gherghina, Christine Dewi, Asma Iqbal and Shahzad Mumtaz
Computation 2024, 12(5), 101; https://doi.org/10.3390/computation12050101 (registering DOI) - 15 May 2024
Abstract
This study is an in-depth exploration of the nascent field of Natural Language Processing (NLP) and generative Artificial Intelligence (AI), and it concentrates on the vital task of distinguishing between human-generated text and content that has been produced by AI models. Particularly, this [...] Read more.
This study is an in-depth exploration of the nascent field of Natural Language Processing (NLP) and generative Artificial Intelligence (AI), and it concentrates on the vital task of distinguishing between human-generated text and content that has been produced by AI models. Particularly, this research pioneers the identification of financial text derived from AI models such as ChatGPT and paraphrasing tools like QuillBot. While our primary focus is on financial content, we have also pinpointed texts generated by paragraph rewriting tools and utilized ChatGPT for various contexts this multiclass identification was missing in previous studies. In this paper, we use a comprehensive feature extraction methodology that combines TF–IDF with Word2Vec, along with individual feature extraction methods. Importantly, combining a Random Forest model with Word2Vec results in impressive outcomes. Moreover, this study investigates the significance of the window size parameters in the Word2Vec approach, revealing that a window size of one produces outstanding scores across various metrics, including accuracy, precision, recall and the F1 measure, all reaching a notable value of 0.74. In addition to this, our developed model performs well in classification, attaining AUC values of 0.94 for the ‘GPT’ class; 0.77 for the ‘Quil’ class; and 0.89 for the ‘Real’ class. We also achieved an accuracy of 0.72, precision of 0.71, recall of 0.72, and F1 of 0.71 for our extended prepared dataset. This study contributes significantly to the evolving landscape of AI text identification, providing valuable insights and promising directions for future research. Full article
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23 pages, 11650 KiB  
Article
Sweeteners Show a Plasticizing Effect on PVP K30—A Solution for the Hot-Melt Extrusion of Fixed-Dose Amorphous Curcumin-Hesperetin Solid Dispersions
by Kamil Wdowiak, Lidia Tajber, Andrzej Miklaszewski and Judyta Cielecka-Piontek
Pharmaceutics 2024, 16(5), 659; https://doi.org/10.3390/pharmaceutics16050659 (registering DOI) - 15 May 2024
Abstract
The co-administration of curcumin and hesperetin might be beneficial in terms of neuroprotective activity; therefore, in this study, we attempted to develop a fixed-dose formulation comprising these two compounds in an amorphous state. The aim of obtaining an amorphous state was to overcome [...] Read more.
The co-administration of curcumin and hesperetin might be beneficial in terms of neuroprotective activity; therefore, in this study, we attempted to develop a fixed-dose formulation comprising these two compounds in an amorphous state. The aim of obtaining an amorphous state was to overcome the limitations of the low solubility of the active compounds. First, we assessed the possibility of using popular sweeteners (erythritol, xylitol, and sorbitol) as plasticizers to reduce the glass transition temperature of PVP K30 to prepare the polymer–excipient blends, which allowed the preparation of amorphous solid dispersions via hot-melt extrusion at a temperature below the original glass transition of PVP K30. Erythritol proved to be the superior plasticizer. Then, we focused on the development of fixed-dose amorphous solid dispersions of curcumin and hesperetin. Powder X-ray diffraction and thermal analysis confirmed the amorphous character of dispersions, whereas infrared spectroscopy helped to assess the presence of intermolecular interactions. The amorphous state of the produced dispersions was maintained for 6 months, as shown in a stability study. Pharmaceutical parameters such as dissolution rate, solubility, and in vitro permeability through artificial membranes were evaluated. The best improvement in these features was noted for the dispersion, which contained 15% of the total content of the active compounds with erythritol used as the plasticizer. Full article
(This article belongs to the Special Issue Further Research in Polyphenols Formulations)
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18 pages, 49677 KiB  
Article
Riparian Forests of Alnus Species Communities and Their Role in Sustainability in the Romanian Carpathians and Adjacent Regions
by Daniela Mogîldea, Tiberiu C. Sahlean and Claudia Biță-Nicolae
Sustainability 2024, 16(10), 4130; https://doi.org/10.3390/su16104130 (registering DOI) - 15 May 2024
Abstract
Alnus riparian communities are important for ecological stability. Data on Alnus species were gathered from herbaria and literature, revealing that 54.39% of the information refers to Alnus glutinosa, 39.42% to Alnus incana, and 6.18% to Alnus pubescens. This information highlights [...] Read more.
Alnus riparian communities are important for ecological stability. Data on Alnus species were gathered from herbaria and literature, revealing that 54.39% of the information refers to Alnus glutinosa, 39.42% to Alnus incana, and 6.18% to Alnus pubescens. This information highlights the widespread occurrence of A. glutinosa and A. incana, as described in distribution maps, contrasting with the more limited range of the hybrid A. pubescens. Principal component analysis (PCA), utilizing standardized factors, was carried out on 217 relevés of the communities of the studied species. In these relevés, we identified a total of 169 plant species, categorized as herbaceous (83%), trees (11%), and shrubs (6%). Three distinct forest communities, Stellario nemorum-Alnetum glutinosae, Alnetum incanae, and Telekio speciosae-Alnetum incanae, emerged from relevé groups. The distribution maps of the three taxa were overlaid on maps of the region’s protected areas, revealing a substantial presence of these taxa within the protected zones. The research aims to highlight the sustainability and conservation importance of Alnus communities in the Romanian Carpathians, to contribute to ongoing conservation efforts and promote the viability and resilience of these ecologically important wetland habitats. Full article
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20 pages, 3418 KiB  
Article
Renewable Energy Investments in Poland: Goals, Socio-Economic Benefits, and Development Directions
by Anna Dębicka, Karolina Olejniczak, Bartosz Radomski, Dariusz Kurz and Dawid Poddubiecki
Energies 2024, 17(10), 2374; https://doi.org/10.3390/en17102374 (registering DOI) - 15 May 2024
Abstract
Renewable energy sources (RES) will play a key role in the transition to clean energy. Financial and socio-economic benefits determine the investment management in these energy sources. This article aims to indicate current energy policy goals, present socio-economic benefits resulting from renewable energy [...] Read more.
Renewable energy sources (RES) will play a key role in the transition to clean energy. Financial and socio-economic benefits determine the investment management in these energy sources. This article aims to indicate current energy policy goals, present socio-economic benefits resulting from renewable energy investments, and review further development directions in Poland. The research was carried out using desk research, case studies, and literature review methods to provide a broader economic context for RES investments. The scope of the research included both the Polish and the European Union contexts. The authors examined the Polish objectives of investment in renewable energy contained in strategic, planning, and other legal documents compared to EU targets, reviewed possible investments in renewable energy, and indicated wind farms and photovoltaic investments as the most effective ones from the point of view of further development which aims to meet the EU’s goals by 2030. The authors also demonstrated a wide range of socio-economic benefits based on literature reviews, analysis of policy documents, and regulations regarding the energy sector, and examined a specific example of investment implementation and identified the ecosystem of beneficiaries and their benefits. Full article
(This article belongs to the Section A2: Solar Energy and Photovoltaic Systems)
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31 pages, 3930 KiB  
Article
Perception of Locals on Multiple Contributions of NTFPs to the Livelihoods of Forest Fringe Communities in Ghana
by Obed Asamoah, Jones Abrefa Danquah, Dastan Bamwesigye, Emmanuel Amoah Boakye, Mark Appiah and Ari Pappinen
Forests 2024, 15(5), 861; https://doi.org/10.3390/f15050861 (registering DOI) - 15 May 2024
Abstract
Forest-dwelling residents frequently collect non-timber forest products (NTFPs) for various reasons, such as food, medicine, firewood, religious reasons, or handicrafts. This study examines the multiple benefits derived from NTFPs and how they contribute to the livelihoods of Ghanaian communities to alleviate poverty. Resources [...] Read more.
Forest-dwelling residents frequently collect non-timber forest products (NTFPs) for various reasons, such as food, medicine, firewood, religious reasons, or handicrafts. This study examines the multiple benefits derived from NTFPs and how they contribute to the livelihoods of Ghanaian communities to alleviate poverty. Resources and services provided by NTFPs have an essential role in providing economic, nutritional, medicinal, cultural, and environmental benefits. This study examines the diverse range of NTFPs locals collect, such as chewing sticks, games, herbs, honey, leaves, mushrooms, pestles, raffia and palms, snails, and straws. In addition to serving different purposes, these NTFPs contribute to income generation, food security, health care, cultural practices, and the protection of the environment. A qualitative research approach was used in this study to collect data through semi-structured interviews and focus groups with members on multiple collections of NTFPs and their multiple benefits. We interviewed 732 residents regarding their multiple NTFPs and their potential to improve the livelihood of the locals. The data for the study were analysed using descriptive statistics. As a result of the survey, the frequency and percentages of responses were analysed for each indicator related to multiple values of NTFPs. Both males and females collected a list of NTFPs during the survey. Regarding NTFPs used for sale, 275 were reported, representing 37.57% of the total. In addition to emphasising the importance of sustainable management practices and equitable distribution of benefits, the study explores the multiple benefits of NTFPs for poverty alleviation in Ghanaian communities. It is essential to ensure the conservation of forest ecosystems and promote inclusive policies to harness the potential of NTFPs and maximise their positive impact on livelihoods. NTFPs provide multiple benefits for Ghanaian communities, including income, nutrition, healthcare, cultural preservation, and environmental sustainability. To promote sustainable development, it is imperative to understand the role of NTFPs and implement appropriate strategies. Full article
(This article belongs to the Special Issue Economic Valuation of Forest Resources)
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3 pages, 155 KiB  
Editorial
Special Issue: Molecular Ecology, Physiology and Biochemistry of Insects 3.0
by Klaus H. Hoffmann
Int. J. Mol. Sci. 2024, 25(10), 5390; https://doi.org/10.3390/ijms25105390 (registering DOI) - 15 May 2024
Abstract
With the outstanding work of Sir Vincent B [...] Full article
(This article belongs to the Special Issue Molecular Ecology, Physiology and Biochemistry of Insects 3.0)
15 pages, 2682 KiB  
Article
Workout Classification Using a Convolutional Neural Network in Ensemble Learning
by Gi-Seung Bang and Seung-Bo Park
Sensors 2024, 24(10), 3133; https://doi.org/10.3390/s24103133 (registering DOI) - 15 May 2024
Abstract
To meet the increased demand for home workouts owing to the COVID-19 pandemic, this study proposes a new approach to real-time exercise posture classification based on the convolutional neural network (CNN) in an ensemble learning system. By utilizing MediaPipe, the proposed system extracts [...] Read more.
To meet the increased demand for home workouts owing to the COVID-19 pandemic, this study proposes a new approach to real-time exercise posture classification based on the convolutional neural network (CNN) in an ensemble learning system. By utilizing MediaPipe, the proposed system extracts the joint coordinates and angles of the human body, which the CNN uses to learn the complex patterns of various exercises. Additionally, this new approach enhances classification performance by combining predictions from multiple image frames using an ensemble learning method. Infinity AI’s Fitness Basic Dataset is employed for validation, and the experiments demonstrate high accuracy in classifying exercises such as arm raises, squats, and overhead presses. The proposed model demonstrated its ability to effectively classify exercise postures in real time, achieving high rates in accuracy (92.12%), precision (91.62%), recall (91.64%), and F1 score (91.58%). This indicates its potential application in personalized fitness recommendations and physical therapy services, showcasing the possibility for beneficial use in these fields. Full article
(This article belongs to the Special Issue Augmented Reality-Based Navigation System for Healthcare)
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24 pages, 15455 KiB  
Article
Sensitivity Simulations of Wind-driven Water Circulation in İzmit Bay
by Sabri Mutlu, Barış Önol, Mehmet Ilıcak and Hüsne Altıok
J. Mar. Sci. Eng. 2024, 12(5), 824; https://doi.org/10.3390/jmse12050824 (registering DOI) - 15 May 2024
Abstract
İzmit Bay, a 50 km long inlet at the eastern end of the Marmara Sea, is crucial for the region’s economy, culture, and marine ecosystem. The bay’s water circulation regulates nutrient distribution, stratification, sedimentation, oxygen levels, heat, and pollution levels. It is also [...] Read more.
İzmit Bay, a 50 km long inlet at the eastern end of the Marmara Sea, is crucial for the region’s economy, culture, and marine ecosystem. The bay’s water circulation regulates nutrient distribution, stratification, sedimentation, oxygen levels, heat, and pollution levels. It is also influenced by meteorological events, such as short-term moderate to strong wind conditions. This study investigated the sensitivity of İzmit Bay Water Circulation to wind speed, direction, and duration using the MITgcm model with Orlanski boundary conditions and process-oriented modeling. The simulations showed that under weak forcing conditions, seawater temperature, salinity, and stratification do not significantly vary. However, strong forcing and wind speeds (statistically defined by percentiles of observation data) of 4.9 m/s (75%), 6.7 m/s (90%), and 10.1 m/s (99%) generate significant mesoscale and sub-mesoscale processes, depending on the direction. Westerly component winds cause downwelling at the eastern coastline, while easterly component winds bring sub-surface water to the surface. Strong winds from N, NE, and E sectors lead to the rise in lower-layer waters in the western basin, forcing them to overflow through the Hersek Delta sill into the central basin. Overall, severe wind events greater than 4.9 m/s (75%) significantly affect the bay’s hydrography by transforming the upper layer, with a decrease in temperature up to 5 °C and an increase in salinity up to 10 ppt. Full article
(This article belongs to the Section Physical Oceanography)
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19 pages, 264 KiB  
Article
Evaluation of a Conference on Cancer-Related Financial and Legal Issues: A Potential Resource to Counter Financial Toxicity
by Lauren V. Ghazal, Joanna Doran, Monica Bryant, Brad Zebrack and Margaret I. Liang
Curr. Oncol. 2024, 31(5), 2817-2835; https://doi.org/10.3390/curroncol31050214 (registering DOI) - 15 May 2024
Abstract
This study describes the conception, development, and growth of the Triage Cancer Conference hosted by Triage Cancer, a national nonprofit organization providing free legal and financial education to the cancer community. We conducted a retrospective analysis of post-conference participant surveys. Descriptive statistics were [...] Read more.
This study describes the conception, development, and growth of the Triage Cancer Conference hosted by Triage Cancer, a national nonprofit organization providing free legal and financial education to the cancer community. We conducted a retrospective analysis of post-conference participant surveys. Descriptive statistics were calculated for participant demographics, and acceptability, feasibility, and appropriateness were evaluated. From 2016–2021, 1239 participants attended the conference and completed post-conference surveys. Participants included social workers (33%), nurses (30%), and cancer patients/survivors (21%), with representation from over 48 states. Among those who reported race, 16% were Black, and 7% were Hispanic. For acceptability, more than 90% of participants felt that the conference content, instructors, and format were suitable and useful. For feasibility, more than 90% of participants felt that the material was useful, with 93–96% reporting that they were likely to share the information and 98% reporting that they would attend another triage cancer event. Appropriateness was also high, with >80–90% reporting that the sessions met the pre-defined objectives. Triage Cancer fills an important gap in mitigating financial toxicity, and formal evaluation of these programs allows us to build evidence of the role and impact of these existing resources. Future research should focus on adding validated patient-reported outcomes, longer-term follow-up, and ensuring inclusion and evaluation of outcome metrics among vulnerable populations. Full article
(This article belongs to the Section Health Economics)
23 pages, 11765 KiB  
Article
Traffic Flow Optimization at Toll Plaza Using Proactive Deep Learning Strategies
by Habib Talha Hashmi, Sameer Ud-Din, Muhammad Asif Khan, Jamal Ahmed Khan, Muhammad Arshad and Muhammad Usman Hassan
Infrastructures 2024, 9(5), 87; https://doi.org/10.3390/infrastructures9050087 (registering DOI) - 15 May 2024
Abstract
Global urbanization and increasing traffic volume have intensified traffic congestion throughout transportation infrastructure, particularly at toll plazas, highlighting the critical need to implement proactive transportation infrastructure solutions. Traditional toll plaza management approaches, often relying on manual interventions, suffer from inefficiencies that fail to [...] Read more.
Global urbanization and increasing traffic volume have intensified traffic congestion throughout transportation infrastructure, particularly at toll plazas, highlighting the critical need to implement proactive transportation infrastructure solutions. Traditional toll plaza management approaches, often relying on manual interventions, suffer from inefficiencies that fail to adapt to dynamic traffic flow and are unable to produce preemptive control strategies, resulting in prolonged queues, extended travel times, and adverse environmental effects. This study proposes a proactive traffic control strategy using advanced technologies to combat toll plaza congestion and optimize traffic management. The approach involves deep learning convolutional neural network models (YOLOv7–Deep SORT) for vehicle counting and an extended short-term memory model for short-term arrival rate prediction. When projected arrival rates exceed a threshold, the strategy proactively activates variable speed limits (VSLs) and ramp metering (RM) strategies during peak hours. The novelty of this study lies in its predictive and adaptive capabilities, ensuring efficient traffic flow management. Validated through a case study at Ravi Toll Plaza Lahore using PTV VISSIMv7, the proposed method reduces queue length by 57% and vehicle delays by 47% while cutting fuel consumption and pollutant emissions by 28.4% and 34%, respectively. Additionally, by identifying the limitations of conventional approaches, this study presents a novel framework alongside the proposed strategy to bridge the gap between theory and practice, making it easier for toll plaza operators and transportation authorities to adopt and benefit from advanced traffic management techniques. Ultimately, this study underscores the importance of integrated and proactive traffic control strategies in enhancing traffic management, minimizing congestion, and fostering a more sustainable transportation system. Full article
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10 pages, 5931 KiB  
Article
Comparative Study of Microstructure and Phase Composition of Amorphous–Nanocrystalline Fe-Based Composite Material Produced by Laser Powder Bed Fusion in Argon and Helium Atmosphere
by Danil Erutin, Anatoliy Popovich and Vadim Sufiiarov
Materials 2024, 17(10), 2343; https://doi.org/10.3390/ma17102343 (registering DOI) - 15 May 2024
Abstract
Laser powder bed fusion (LPBF) is a prospective and promising technique of additive manufacturing of which there is a growing interest for the development and production of Fe-based bulk metallic glasses and amorphous–nanocrystalline composites. Many factors affect the quality and properties of the [...] Read more.
Laser powder bed fusion (LPBF) is a prospective and promising technique of additive manufacturing of which there is a growing interest for the development and production of Fe-based bulk metallic glasses and amorphous–nanocrystalline composites. Many factors affect the quality and properties of the resulting material, and these factors are being actively investigated by many researchers, however, the factor of the inert gas atmosphere used in the process remains virtually unexplored for Fe-based metallic glasses and composites at this time. Here, we present the results of producing amorphous–nanocrystalline composites from amorphous Fe-based powder via LPBF using argon and helium atmospheres. The analysis of the microstructures and phase compositions demonstrated that using helium as an inert gas in the LPBF resulted in a nearly three-fold increase in the amorphization degree of the material. Additionally, it had a beneficial impact on phase composition and structure in a heat-affected zone. The received results may help to develop approaches to control and improve the structural-phase state of amorphous–nanocrystalline compositional materials obtained via LPBF. Full article
(This article belongs to the Special Issue Advances in Additive Manufacturing: Characteristics and Innovation)
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9 pages, 231 KiB  
Article
Doing the Word: Reawakening the Church to Save Society in Southern Africa
by Kimion Tagwirei
Religions 2024, 15(5), 608; https://doi.org/10.3390/rel15050608 (registering DOI) - 15 May 2024
Abstract
Southern African societies are presently beleaguered by manifold socio-economic, political, and environmental challenges. Ordinary people long for answers to questions about how to mitigate these challenges. Meanwhile, the Church mostly preaches the gospel and establishes and grows denominations across the world. Proclaiming the [...] Read more.
Southern African societies are presently beleaguered by manifold socio-economic, political, and environmental challenges. Ordinary people long for answers to questions about how to mitigate these challenges. Meanwhile, the Church mostly preaches the gospel and establishes and grows denominations across the world. Proclaiming the gospel in word is good; however, without demonstrating the gospel with transformational deeds, the Church remains Salvationist and partially missionary. Bearing in mind that the integral mission of the Church is advancing the gospel holistically, fractional mindfulness of the gospel, hearing the words without performing the corresponding deeds, is defacing its identity. Toda–, this situation is problematic and helpless, as society is in dire need of a wholesome Church that acts in accordance with its own faith and values and attends to the soul, the body, and all other facets of life. Much has been published about the integral mission of the Church, though little has been said about its role in social action. By qualitatively reviewing the literature and observing the Southern African context and some biblical examples, this paper finds the integral mission to be the predominant and comprehensive purpose of the existence of the Church. While the Church could be aware of its mandate, it should be reawakened so that it becomes a doer of the Word and stands out as the salt and light of the world by contributing to addressing the needs of society. Full article
32 pages, 4170 KiB  
Article
Role of Natural Binding Proteins in Therapy and Diagnostics
by Marco Eigenfeld, Kilian F. M. Lupp and Sebastian P. Schwaminger
Life 2024, 14(5), 630; https://doi.org/10.3390/life14050630 (registering DOI) - 15 May 2024
Abstract
This review systematically investigates the critical role of natural binding proteins (NBPs), encompassing DNA-, RNA-, carbohydrate-, fatty acid-, and chitin-binding proteins, in the realms of oncology and diagnostics. In an era where cancer continues to pose significant challenges to healthcare systems worldwide, the [...] Read more.
This review systematically investigates the critical role of natural binding proteins (NBPs), encompassing DNA-, RNA-, carbohydrate-, fatty acid-, and chitin-binding proteins, in the realms of oncology and diagnostics. In an era where cancer continues to pose significant challenges to healthcare systems worldwide, the innovative exploration of NBPs offers a promising frontier for advancing both the diagnostic accuracy and therapeutic efficacy of cancer management strategies. This manuscript provides an in-depth examination of the unique mechanisms by which NBPs interact with specific molecular targets, highlighting their potential to revolutionize cancer diagnostics and therapy. Furthermore, it discusses the burgeoning research on aptamers, demonstrating their utility as ‘nucleic acid antibodies’ for targeted therapy and precision diagnostics. Despite the promising applications of NBPs and aptamers in enhancing early cancer detection and developing personalized treatment protocols, this review identifies a critical knowledge gap: the need for comprehensive studies to understand the diverse functionalities and therapeutic potentials of NBPs across different cancer types and diagnostic scenarios. By bridging this gap, this manuscript underscores the importance of NBPs and aptamers in paving the way for next-generation diagnostics and targeted cancer treatments. Full article
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10 pages, 1901 KiB  
Article
A Comparative Study on Electrochemical Performance of Single versus Dual Networks in Lithium Metal/Polysulfide-Polyoxide Co-Network/Lithium Titanium Oxide Cathode
by Hyunsang Lee, Jae-Won Choi and Thein Kyu
Batteries 2024, 10(5), 163; https://doi.org/10.3390/batteries10050163 (registering DOI) - 15 May 2024
Abstract
The present article introduces a strategy for controlling oxidation and reduction reactions within polymer electrolyte membrane (PEM) networks as a means of enhancing storage capacity through the complexation of dissociated lithium cations with multifunctional groups of the polymer network. Specifically, co-polymer networks based [...] Read more.
The present article introduces a strategy for controlling oxidation and reduction reactions within polymer electrolyte membrane (PEM) networks as a means of enhancing storage capacity through the complexation of dissociated lithium cations with multifunctional groups of the polymer network. Specifically, co-polymer networks based on polysulfide (PS) and polyoxide (PO) precursors, photo-cured in the presence of succinonitrile (SCN) and lithium bis(trifluoro methane sulfonyl imide) (LiTFSI) salt, exhibited ionic conductivity on the order of mid 10−4 S/cm at ambient temperature in the 30/35/35 (weight %) composition. Lithium titanate (LTO, Li4Ti5O12) electrode was chosen as an anode (i.e., a potential source of Li ions) against lithium iron phosphate (LFP, LiFePO4) cathode in conjunction with polysulfide-co-polyoxide dual polyelectrolyte networks to control viscosity for 3D printability on conformal surfaces of drone and aeronautic vehicles. It was found that the PS-co-PO dual network-based polymer electrolyte containing SCN plasticizer and LiTFSI salt exhibited extra storage capacity (i.e., specific capacity of 44 mAh/g) with the overall specific capacity of 170 mAh/g (i.e., for the combined LTO electrode and PEM) initially that stabilized at 153 mAh/g after 50th cycles with a reasonable capacity retention of over 90% and Coulombic efficiency of over 99%. Of particular interest is the observation of the improved electrochemical performance of the polysulfide-co-polyoxide electrolyte dual-network relative to that of the polyoxide electrolyte single-network. Full article
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12 pages, 7370 KiB  
Communication
Fault Kinematics of the 2023 Mw 6.0 Jishishan Earthquake, China, Characterized by Interferometric Synthetic Aperture Radar Observations
by Xing Huang, Yanchuan Li, Xinjian Shan, Meijiao Zhong, Xuening Wang and Zhiyu Gao
Remote Sens. 2024, 16(10), 1746; https://doi.org/10.3390/rs16101746 (registering DOI) - 15 May 2024
Abstract
Characterizing the coseismic slip behaviors of earthquakes could offer a better understanding of regional crustal deformation and future seismic potential assessments. On 18 December 2023, an Mw 6.0 earthquake occurred on the Lajishan–Jishishan fault system (LJFS) in the northeastern Tibetan Plateau, causing serious [...] Read more.
Characterizing the coseismic slip behaviors of earthquakes could offer a better understanding of regional crustal deformation and future seismic potential assessments. On 18 December 2023, an Mw 6.0 earthquake occurred on the Lajishan–Jishishan fault system (LJFS) in the northeastern Tibetan Plateau, causing serious damage and casualties. The seismogenic fault hosting this earthquake is not well constrained, as no surface rupture was identified in the field. To address this issue, in this study, we use Interferometric Synthetic Aperture Radar (InSAR) data to investigate the coseismic surface deformation of this earthquake and invert both ascending and descending line-of-sight observations to probe the seismogenic fault and its slip characteristics. The InSAR observations show up to ~6 cm surface uplift caused by the Jishishan earthquake, which is consistent with the thrust-dominated focal mechanism. A Bayesian-based dislocation modeling indicates that two fault models, with eastern and western dip orientations, could reasonably fit the InSAR observations. By calculating the coseismic Coulomb failure stress changes (∆CFS) induced by both fault models, we find that the east-dipping fault scenario could reasonably explain the aftershock distributions under the framework of stress triggering, while the west-dipping fault scenario produced a negative ∆CFS in the region of dense aftershocks. Integrating regional geological structures, we suggest that the seismogenic fault of the Jishishan earthquake, which strikes NNE with a dip of 56° to the east, may be either the Jishishan western margin fault or a secondary buried branch. The optimal finite-fault slip modeling shows that the coseismic slip was dominated by reverse slip and confined to a depth range between ~5 and 15 km. The released seismic moment is 1.61 × 1018 N·m, which is equivalent to an Mw 6.07 earthquake. While the Jishishan earthquake ruptured a fault segment of approximately 20 km, it only released a small part of the seismic moment that was accumulated along the 220 km long Lajishan–Jishishan fault system. The remaining segments of the Lajishan–Jishishan fault system still have the capability to generate moderate-to-large earthquakes in the future. Full article
(This article belongs to the Special Issue Monitoring Geohazard from Synthetic Aperture Radar Interferometry)
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26 pages, 3044 KiB  
Review
Programmed Cell Death Reversal: Polyamines, Effectors of the U-Turn from the Program of Death in Helianthus tuberosus L.
by Donatella Serafini-Fracassini and Stefano Del Duca
Int. J. Mol. Sci. 2024, 25(10), 5386; https://doi.org/10.3390/ijms25105386 (registering DOI) - 15 May 2024
Abstract
This review describes a 50-year-long research study on the characteristics of Helianthus tuberosus L. tuber dormancy, its natural release and programmed cell death (PCD), as well as on the ability to change the PCD so as to return the tuber to a life [...] Read more.
This review describes a 50-year-long research study on the characteristics of Helianthus tuberosus L. tuber dormancy, its natural release and programmed cell death (PCD), as well as on the ability to change the PCD so as to return the tuber to a life program. The experimentation on the tuber over the years is due to its particular properties of being naturally deficient in polyamines (PAs) during dormancy and of immediately reacting to transplants by growing and synthesizing PAs. This review summarizes the research conducted in a unicum body. As in nature, the tuber tissue has to furnish its storage substances to grow vegetative buds, whereby its destiny is PCD. The review’s main objective concerns data on PCD, the link with free and conjugated PAs and their capacity to switch the destiny of the tuber from a program of death to one of new life. PCD reversibility is an important biological challenge that is verified here but not reported in other experimental models. Important aspects of PA features are their capacity to change the cell functions from storage to meristematic ones and their involvement in amitosis and differentiation. Other roles reported here have also been confirmed in other plants. PAs exert multiple diverse roles, suggesting that they are not simply growth substances, as also further described in other plants. Full article
(This article belongs to the Section Biochemistry)
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