Mammalian oocyte development depends on the temporally controlled translation of maternal transcripts, particularly in the coordination of meiotic and early embryonic development when transcription has ceased. The translation of mRNA is regulated by various RNA-binding proteins. We show that the absence of cytoplasmic polyadenylation element-binding protein 3 (CPEB3) negatively affects female reproductive fitness. CPEB3-depleted oocytes undergo meiosis normally but experience early embryonic arrest due to a disrupted transcriptome, leading to aberrant protein expression and the subsequent failure of embryonic transcription initiation. We found that CPEB3 stabilizes a subset of mRNAs with a significantly longer 3’UTR that is enriched in its distal region with cytoplasmic polyadenylation elements. Overall, our results suggest that CPEB3 is an important maternal factor that regulates the stability and translation of a subclass of mRNAs that are essential for the initiation of embryonic transcription and thus for embryonic development. Full article

This paper studies distributed optimal control for non-cooperative systems involving time-fractional hyperbolic operators. Through the application of the Lax–Milgram theorem, we confirm the existence and uniqueness of weak solutions. Central to our approach is the utilization of the linear quadratic cost functional, which is meticulously crafted to encapsulate the interplay between the system’s state and control variables. This functional serves as a pivotal tool in imposing constraints on the dynamic system under consideration, facilitating a nuanced understanding of its controllability. Using the Euler–Lagrange first-order optimality conditions with an adjoint problem defined by means of the right-time fractional derivative in the Caputo sense, we obtain an optimality system for the optimal control. Finally, some examples are analyzed. Full article

Water pollution, particularly from heavy metals, poses a significant threat to global health, necessitating efficient and environmentally friendly removal methods. This study introduces novel zeolite-based adsorbents, specifically alkali-activated foamed zeolite (AAFZ), for the effective adsorption of Cu(II) and Ni(II) ions from aqueous solutions. The adsorbents’ capabilities were comprehensively characterized through kinetic and isotherm analyses. Alkaline activation induced changes in chemical composition and crystalline structure, as observed via XRF and XRD analyses. AAFZ exhibited a significantly larger pore volume (1.29 times), higher Si/Al ratio (1.15 times), and lower crystallinity compared to ZZ50, thus demonstrating substantially higher adsorption capacity for Cu(II) and Ni(II) compared to ZZ50. The maximum monolayer adsorption capacities of ZZ50 and AAFZ for Cu(II) were determined to be 69.28 mg/g and 99.54 mg/g, respectively. In the case of Ni(II), the maximum monolayer adsorption capacities for ZZ50 and AAFZ were observed at 48.53 mg/g and 88.99 mg/g, respectively. For both adsorbents, the optimum pH for adsorption of Cu(II) and Ni(II) was found to be 5 and 6, respectively. Equilibrium was reached around 120 min, and the pseudo-second-order kinetics accurately depicted the chemisorption process. The Langmuir isotherm model effectively described monolayer adsorption for both adsorbents. Furthermore, the regeneration experiment demonstrated that AAFZ could be regenerated for a minimum of two cycles using hydrochloric acid (HCl). These findings highlight the potential of the developed adsorbents as promising tools for effective and practical adsorption applications. Full article

This study introduces a decision support framework that integrates aircraft trajectory optimization and arrival scheduling to facilitate efficient management of descent operations for arriving aircraft within terminal maneuvering areas. The framework comprises three modules designed to tackle specific challenges in the descent process. The first module formulates and solves a trajectory optimization problem, generating a range of candidate descent trajectories for each arriving aircraft. The options for descent operations include step-down descent operation, Continuous Descent Operation (CDO), and CDO with a lateral path stretching strategy. The second module addresses the assignment of conflict-free trajectories to aircraft, determining precise arrival times at each waypoint. This is achieved by solving an aircraft arrival scheduling problem. To overcome computational complexities, a novel variable neighborhood search algorithm is proposed as the solution approach. This algorithm utilizes three neighborhood structures within an extended relaxing and solving framework, and incorporates a tabu search algorithm to enhance the efficiency of the search process in the solution space. The third module focuses on comparing the total cost incurred from flight delays and fuel consumption across the three descent operations, enabling the selection of the most suitable operation for the descent process. The decision support framework is evaluated using real air traffic data from Guangzhou Baiyun International Airport. Experimental results demonstrate that the framework effectively supports air traffic controllers by scheduling more cost-efficient descent operations for arrival aircraft. Full article

Rembang Regency is located on the north coast of Java Island, Central Java Province, Indonesia, which has many beaches ideal for tourism activities. Even though it has the charm of beaches, natural tourist destinations are still the primary choice compared to cultural and artificial sites. However, limited studies exist regarding standard indicators for assessing natural tourism potential in Rembang Regency, which is essential for identifying potential tourist locations. This research focuses on grouping indicators of natural tourism potential based on six main aspects: attractions, amenities, accommodation, activity, accessibility, and ancillary services, environment in tourist areas, and human resources considerations. A taxonomic model will be utilized to develop a procedure for determining natural tourism potential, including indicator weighing via a hierarchical analysis. The findings will yield a taxonomy model aiding information and knowledge management, fostering information sharing and utilization. Moreover, the established procedures will facilitate an accurate and efficient determination of natural tourism potential. This research aims to contribute to sustainable natural tourism management in Rembang Regency, preserving nature while enhancing the tourist experience. Full article

The linearization of nonlinear differential equations represents a robust approach to solution derivation, typically achieved through Lie symmetry analysis. This study adopts a geometric methodology grounded in the Eisenhart lift, revealing transformative techniques that linearize a set of second-order ordinary differential equations. The research underscores the effectiveness of this geometric approach in the linearization of a class of Newtonian systems that cannot be linearized through symmetry analysis. Full article

The β-adrenergic drug Mirabegron, a drug initially used for the treatment of an overactive bladder, has new potential indications and is hydrolyzed by butyrylcholinesterase (BChE). This compound is one of the only arylacylamide substrates to be catabolized by BChE. A steady-state kinetic analysis at 25°C and pH 7.0 showed that the enzyme behavior is Michaelian with this substrate and displays a long pre-steady-state phase characterized by a burst. The induction time, τ, increased with substrate concentration (τ≈18 min at maximum velocity). The kinetic behavior was interpreted in terms of hysteretic behavior, resulting from a slow equilibrium between two enzyme active forms, E and E’. The pre-steady-state phase with the highest activity corresponds to action of the E form, and the steady state corresponds to action of the E’ form. The catalytic parameters were determined as k_cat = 7.3 min⁻¹ and K_m = 23.5 μM for the initial (burst) form E, and k_cat = 1.6 min⁻¹ and K_m = 3.9 μM for the final form E’. Thus, the higher affinity of E’ for Mirabegron triggers the slow enzyme state equilibrium toward a slow steady state. Despite the complexity of the reaction mechanism of Mirabegron with BChE, slow BChE-catalyzed degradation of Mirabegron in blood should have no impact on the pharmacological activities of this drug. Full article

Background: Several risk scores have been derived to predict the risk of infective endocarditis (IE) amongst patients with Staphylococcus aureus bacteraemia (SAB), which helps to guide clinical management. Methods: We prospectively studied 634 patients admitted with SAB. The cohort was stratified into those with or without IE, and the PREDICT Day 1, Day 5 and VIRSTA scores were tabulated. Area under the receiver operating characteristic (AUC) curves were constructed to compare the performance of each score. Results: Of the 634 patients examined, 36 (5.7%) had IE. These patients were younger (51.6 ± 20.1 vs. 59.2 ± 18.0 years, p = 0.015), tended to have community acquisition of bacteraemia (41.7% vs. 17.9%, p < 0.001), and had persistent bacteraemia beyond 72 h (19.4% vs. 6.0%, p = 0.002). The VIRSTA score had the best performance in predicting IE (AUC 0.76, 95%CI 0.66–0.86) compared with PREDICT Day 1 and Day 5. A VIRSTA score of <3 had the best negative predictive value (97.5%), compared with PREDICT Day 1 (<4) and Day 5 (<2) (94.3% and 96.6%, respectively). Conclusions: Overall, the risk scores performed well in our Asian cohort. If applied, 23.5% of the cohort with a VIRSTA ≥ 3 would require TEE, and a score of <3 had an excellent negative predictive value. Full article

Actinomycetes have long been recognized as important sources of clinical antibiotics. However, the exploration of rare actinomycetes, despite their potential for producing bioactive molecules, has remained relatively limited compared to the extensively studied Streptomyces genus. The extensive investigation of Streptomyces species and their natural products has led to a diminished probability of discovering novel bioactive compounds from this group. Consequently, our research focus has shifted towards less explored actinomycetes, beyond Streptomyces, with particular emphasis on Kitasatospora setae (K. setae). The genome of K. setae was annotated and analyzed through whole-genome sequencing using multiple bio-informatics tools, revealing an 8.6 Mbp genome with a 74.42% G+C content. AntiSMASH analysis identified 40 putative biosynthetic gene clusters (BGCs), approximately half of which were recessive and unknown. Additionally, metabolomic mining utilizing mass spectrometry demonstrated the potential for this rare actinomycete to generate numerous bioactive compounds such as glycosides and macrolides, with bafilomycin being the major compound produced. Collectively, genomics- and metabolomics-based techniques confirmed K. setae’s potential as a bioactive secondary metabolite producer that is worthy of further exploration. Full article

To ascertain the effect of low-light stress (80 μmol·m⁻²·s⁻¹) on cucumbers, we report on improving and breeding low-light-tolerant varieties by mining genes related to low-light tolerance. In this study, the quantitative trait locus (QTL) mapping of cucumber plant height and internode length under low-light stress was conducted using the F₂ population, employing specific-length amplified fragment sequencing (SLAF-seq) and phenotypic analysis. A genetic map with a total length of 1114.29 c M was constructed from 1,076,599 SNPs, and 2233 single-nucleotide polymorphism (SNP) markers were distributed on seven linked groups, with an average map distance of 0.50 c M. Two QTLs related to plant height, CsPlH5.1 and CsPlH6.1, were detected on Chr.5 and Chr.6, with a cumulative contribution rate of 16.33%. The contribution rate (PVE), max LOD value, additive effect (ADD), and dominant effect (DOM) of CsPlH5.1 were 9.446%, 4.013, 1.005, and 0.563, respectively. CsPlH5.1 was located between 4,812,907 and 5,159,042 in the Gy14_V2.0 genome of cucumber, with a genetic distance of 0.32 Mb; the interval contained 41 candidate genes, and CsPlH6.1 was found to be located between Marker537985 (171.10 c M) and Marker 537984 (171.55 c M), a range containing only one candidate gene. A total of 42 candidate genes related to photosynthesis, chloroplast development, abiotic stress, and plant growth were found in the location range associated with plant height. Simultaneously, a QTL (Csnd2_NdL6.1) for the second internode length was detected, and the max LOD, ADD, and DOM values were 5.689, 0.384, and −0.19, respectively. Csnd2_NdL6.1 was located between 29,572,188 and 29,604,215, with 0.03 Mb on Chr. 6 including seven candidate genes. The molecular function of the CsGy6G032300 gene is involved with the binding of calcium ions, which may be related to the elongation and growth of plants; however, the population needs to be further expanded for acceptable localization verification. The results of this study provide a preliminary basis for the mining of essential genes of cucumber’s low-light tolerance and identifying low-light-tolerance genes. Full article

Transportation has an essential place in societies and importance to people in terms of its social and economic aspects. Innovative rail systems need to be integrated with developing technologies for transportation. Systemic failures, personnel errors, sabotage, and cyber-attacks in the techniques used will cause a damaged corporate reputation and revenue losses. In this study, cybersecurity attack methods in smart rail systems were determined, and cyber events occurring worldwide through these technologies were analyzed. Risk analysis in terms of transportation safety in smart rail systems was determined by considering the opinions of 10 different experts along with the Analytic Hierarchical Process (AHP) performance criteria. Informatics experts were selected from a group of people with at least 5–15 years of experience. According to these risk analysis calculations, cybersecurity stood out as the most critical security risk at 27.74%. Other risky areas included physical security, calculated at 14.59%, operator errors at 16.20%, and environmental security at 10.93%. Full article

In this study of the alterations of Glypicans 1 to 6 (GPCs) and Notum in plasma, bone marrow mesenchymal stromal cells (BM-MSCs) and osteoblasts in Osteoarthritis (OA), the levels of GPCs and Notum in the plasma of 25 patients and 24 healthy subjects were measured. In addition, BM-MSCs from eight OA patients and eight healthy donors were cultured over a period of 21 days using both a culture medium and an osteogenic medium. Protein and gene expression levels of GPCs and Notum were determined using ELISA and qPCR at 0, 7, 14 and 21 days. GPC5 and Notum levels decreased in the plasma of OA patients, while the BM-MSCs of OA patients showed downexpression of GPC6 and upregulation of Notum. A decrease in GPC5 and Notum proteins and an increase in GPC3 were found. During osteogenic differentiation, elevated GPCs 2, 4, 5, 6 and Notum mRNA levels and decreased GPC3 were observed in patients with OA. Furthermore, the protein levels of GPC2, GPC5 and Notum decreased, while the levels of GPC3 increased. Glypicans and Notum were altered in BM-MSCs and during osteogenic differentiation from patients with OA. The alterations found point to GPC5 and Notum as new candidate biomarkers of OA pathology. Full article

Q fever is a disease caused by Coxiella burnetii that affects many animal species and humans. In ruminants, the disease is responsible for several reproductive disorders (such as abortions, stillbirths, premature births, weak offspring, retained foetal membranes and infertility). An inactivated vaccine based on a phase I antigen of C. burnetii is available for cattle, goats and sheep. This review aims to summarise the scientific literature regarding the efficacy and safety of this vaccine to control the infection in these three domestic ruminant species. Forty-five publications and one experimental veterinary thesis reporting on experimental studies, case reports, mathematical modelling and intervention studies were selected according to the PRISMA guidelines. Although some studies lack control groups or statistical analyses, for all three species, published data show that vaccination often results in a reduction in abortions and an improvement in reproductive performance in comparison with absence of vaccination. There is also evidence, including in infected herds and animals, that vaccination is associated with a reduction in bacterial shedding, both in intensity and duration in comparison with absence of vaccination. For these reasons, in case of human outbreaks, vaccination is one of the pillars of control measures. Vaccination is generally well tolerated, despite the rare occurrence of mild, transient side-effects, such as hyperthermia and reduction in milk yield. Full article

Unsteady pressure-sensitive paint (i-PSP) measurements were performed at a sampling rate of 30 kHz to investigate the near-endwall blade suction surface flow inside a low-pressure turbine cascade operating at engine-relevant high-speed and low-Re conditions. The investigation focuses on the interaction of periodically incoming bar wakes at 500 Hz with the secondary flow and the blade suction surface. The results build on extensive PIV measurements presented in the first part of this two-part publication, which captured the ’negative-jet-effect’ of the wakes throughout the blade passage. The surface pressure distributions are combined with CFD to analyze the flow topology, such as the passage vortex separation line. By analyzing data from phase-locked PIV and PSP measurements, a wake-induced moving pressure gradient negative in space and positive in time is found, which is intensified in the secondary flow region by 33% with respect to midspan. Furthermore, two methods of frequency-filtering based on FFT and SPOD are compared and utilized to associate a pressure fluctuation peak around 678 Hz with separation bubble oscillation. Full article

Multiple-input multiple-output orthogonal frequency division multiplexing (MIMO-OFDM) technology is widely used in integrated radar and communication systems (IRCSs). Moreover, index modulation (IM) is a reliable OFDM transmission scheme in the field of communication, which transmits information by arranging several distinguishable constellations. In this paper, we propose a sparse reconstruction-based joint signal processing scheme for integrated MIMO-OFDM-IM systems. Combining the advantages of MIMO and OFDM-IM technologies, the integrated MIMO-OFDM-IM signal design is realized through the reasonable allocation of bits and subcarriers, resulting in better intercarrier interference (ICI) resistance and a higher transmission efficiency. Taking advantage of the sparseness of OFDM-IM, an improved target parameter estimation method based on sparse signal reconstruction is explored to eliminate the influence of empty subcarriers on the matched filtering at the receiver side. In addition, an improved sequential Monte Carlo signal detection method is introduced to realize the efficient detection of communication signals. The simulation results show that the proposed integrated system is 5 dB lower in the peak sidelobe ratio (PSLR) and 1.5 ×${10}^5$ lower in the number of complex multiplications than the latest MIMO-OFDM system and can achieve almost the same parameter estimation performance. With the same spectral efficiency, it has a lower bit error rate (BER) than existing methods. Full article

This study aimed to develop biocomposite films based on cassava starch and microcrystalline cellulose (MCC) derived from cassava pulp for potential medical packaging applications. MCC was extracted from cassava pulp, and its structure and chemical composition, crystallinity, and thermal properties were characterized. The MCC showed a yield of 14.92% and crystallinity of 46.91%. Different MCC contents (1%, 3%, and 5% w/w of starch) were incorporated into cassava starch films. The effects of MCC contents on film properties, including morphology, thickness, mechanical strength, chemical interactions, moisture content, surface wettability, and water activity index, were studied. The effects of UV-C sterilization on the disinfection of starch/MCC on film properties were determined. Results showed that all starch/MCC films exhibited good transparency and thickness ranging from 127 to 144 µm. As MCC content increased from 1 to 5%, Young’s modulus and tensile strength of the films improved significantly from 112.12 to 488.89 MPa and 3.21 to 11.18 MPa, respectively, while elongation at break decreased from 44.74 to 4.15%. Incorporating MCC also reduced film surface wettability, with the water contact angle increasing from 69.17° to 102.82°. The starch/3%MCC holds promise as a biocomposite film for medical packaging applications, offering advantages in terms of good transparency, mechanical properties, and surface hydrophobicity. Furthermore, the absence of microbial growth in the sterilized gauze pad with sealing in the sterilized starch/3%MCC film confirms that the UV-C sterilization, 30 min for each side at 254 nm effectively eliminated any microorganisms present on the starch/3%MCC film without damaging the film properties. This finding highlights a reliable approach to ensuring the sterility of starch/MCC films for medical packaging applications. Full article

In previous research simulating steelmaking ladles using cold water models, the dosage/volume of the salt tracer solution is one of the factors that has been overlooked by researchers to a certain extent. Previous studies have demonstrated that salt tracers may influence the flow and measured mixing time of fluids in water models. Based on a water model scaled down from an industrial 130-ton ladle by a ratio of 1:3, this study investigates the impact of salt tracer dosage on the transport and mixing of tracers in the water model of gas-stirred ladle with a moderate gas flow rate. A preliminary uncertainty analysis of the experimental mixing time is performed, and the standard deviations were found to be less than 15%. It was observed in the experiments that the transport paths of tracers in the ladle can be classified into two trends. A common trend is that the injected salt solution tracer is asymmetrically transported towards the left sidewall of the ladle by the main circulation. In another trend, the injected salt solution tracer is transported both by the main circulation to the left side wall and by downward flow towards the gas column. The downward flow may be accelerated and become a major flow pattern when the tracer volume increases. For the dimensionless concentration curve, the sinusoidal type, which represents a rapid mixing, is observed at the top surface monitoring points, while the parabolic type is observed at the bottom monitoring points. An exception is the monitoring point at the right-side bottom (close to the asymmetric gas nozzle area), where both sinusoidal-type and parabolic-type curves are observed. Regarding the effect of tracer volume on the curve and mixing time, the curves at the top surface monitoring points are less influenced but curves at the bottom monitoring points are noticeably influenced by the tracer volume. A trend of decreasing and then increasing as the tracer volume increases was found at the top surface monitoring points, while the mixing times at the bottom monitoring points decrease with the increase in the tracer volume. Full article

Mushrooms are one of the indispensable elements of human diets. Edible mushrooms stand out with their aroma and nutritional properties. In this study, some biological activities of the wild edible mushroom Hericium erinaceus were determined. In this context, firstly, the most suitable extraction conditions of the fungus in terms of biological activity were determined. First, 64 different experiments were performed with the Soxhlet device under 40–70 °C extraction temperature, 3–9 h extraction time, and 0.5–2 mg/mL extraction conditions. As a result, a total antioxidant status (TAS) analysis was performed, and the extraction conditions were optimized so that the objective function was the maximum TAS value. The data obtained from the experimental study were modeled with artificial neural networks (ANNs), one of the artificial intelligence methods, and optimized with a genetic algorithm (GA). All subsequent tests were performed using the extract obtained under optimum extraction conditions. The antioxidant capacity of the mushroom was assessed using Rel assay kits and the DPPH and FRAP techniques. The agar dilution method was used to measure the antimicrobial activity. The anti-Alzheimer activity was assessed based on the activities of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). The antiproliferative activity was assessed against the A549 cancer cell line. The total phenolic content was measured using the Folin–Ciocalteu reagent. The measurement of total flavonoids was conducted using the aluminum chloride test. LC-MS/MS equipment was used to screen for the presence of standard chemicals. The optimum extraction conditions were found to be a 60.667 °C temperature, 7.833 h, and 1.98 mg/mL. It was determined that the mushroom has high antioxidant potential. It was determined that the substance was successful at combating common bacterial and fungal strains when used at dosages ranging from 25 to 200 µg/mL. The high antiproliferative effect of the substance was attributed to its heightened concentration. The anti-AChE value was found to be 13.85 μg/mL, while the anti-BChE value was confirmed to be 28.00 μg/mL. The phenolic analysis of the mushroom revealed the presence of 13 chemicals. This investigation found that H. erinaceus exhibits robust biological activity when extracted under appropriate circumstances. Full article

Spermatogenesis is a highly regulated process dependent on androgen receptor (AR) signaling in Sertoli cells. However, the pathogenic mechanisms of spermatogenic failure, by which loss of AR impairs downstream target genes to affect Sertoli cell function, remain incompletely understood. By using microarray analysis, we identified several AR-regulated genes involved in the maturation of spermatogenesis, including chromodomain Y-like protein (CDYL) and transition proteins 1 (TNP-1), that were significantly decreased in ARKO mouse testes. AR and CDYL were found to co-localize and interact in Sertoli cells. The AR–CDYL complex bound to the promoter regions of TNP1 and modulated their transcriptional activity. CDYL acts as a co-regulator of AR transactivation, and its expression is decreased in the Sertoli cells of human testes from patients with azoospermia. The androgen receptor–chromodomain Y-like protein axis plays a crucial role in regulating a network of genes essential for spermatogenesis in Sertoli cells. Disruption of this AR–CDYL regulatory axis may contribute to spermatogenic failure. These findings provide insights into novel molecular mechanisms targeting the AR–CDYL signaling pathway, which may have implications for developing new therapeutic strategies for male infertility. Full article

Fullerene-based amphiphiles are new types of monomers that form self-assemblies with profound applications. The conical fullerene amphiphiles (CFAs) have attracted attention for their uniquely self-assembled structures and have opened up a new field for amphiphile research. The CFAs and CFAs with different substances embedded in cavities are designed and their self-assembly behaviors are investigated using molecular dynamics (MD) simulations. The surface and internal structures of the micelles are analyzed from various perspectives, including micelle size, shape, and solvent-accessible surface area (SASA). The systems studied are all oblate micelles. In comparison, embedding Cl− or embedding Na⁺ in the cavities results in larger micelles and a larger deviation from the spherical shape. Two typical configurations of fullerene surfactant micelles, quadrilateral plane and tetrahedral structure, are presented. The dipole moments of the fullerene molecules are also calculated, and the results show that the embedded negatively charged Cl− leads to a decrease in the polarity of the pure fullerene molecules, while the embedded positively charged Na⁺ leads to an increase. Full article

The detection of faults during an operational process constitutes a crucial objective within the framework of developing a control system to monitor the structure of industrial mechanisms. Even minor faults can give rise to significant consequences that require swift resolution. This research investigates the impact of overtension in the tooth belt transmission and heating of the screw transmission worm on the vibration signals in a robotic system. Utilizing FFT techniques, distinct frequency characteristics associated with different faults were identified. Overtension in the tooth belt transmission caused localized oscillations, addressed by adjusting the acceleration and deceleration speeds. Heating of the screw transmission worm led to widespread disturbances affecting servo stress and positioning accuracy. A fuzzy logic algorithm based on spectral analysis was proposed for adaptive control, considering the vibration’s frequency and amplitude. The simulation results demonstrated effective damage mitigation, reducing wear on the mechanical parts. The diagnostic approach, relying on limited data, emphasized the feasibility of identifying transmission damage, thereby minimizing maintenance costs. This research contributes a comprehensive and adaptive solution for robotic system diagnostics and control, with the proposed fuzzy logic algorithm showing promise for efficient signal processing and machine learning applications. Full article

Venous thromboembolism (VTE) is a challenging clinical obstacle in oncological settings, marked by elevated incidence rates and resulting morbidity and mortality. In the context of cancer-associated thrombosis (CAT), endothelial dysfunction (ED) plays a crucial role in promoting a pro-thrombotic environment as endothelial cells lose their ability to regulate blood flow and coagulation. Moreover, emerging research suggests that this disorder may not only contribute to CAT but also impact tumorigenesis itself. Indeed, a dysfunctional endothelium may promote resistance to therapy and favour tumour progression and dissemination. While extensive research has elucidated the multifaceted mechanisms of ED pathogenesis, the genetic component remains a focal point of investigation. This comprehensive narrative review thus delves into the genetic landscape of ED and its potential ramifications on cancer progression. A thorough examination of genetic variants, specifically polymorphisms, within key genes involved in ED pathogenesis, namely eNOS, EDN1, ACE, AGT, F2, SELP, SELE, VWF, ICAM1, and VCAM1, was conducted. Overall, these polymorphisms seem to play a context-dependent role, exerting both oncogenic and tumour suppressor effects depending on the tumour and other environmental factors. In-depth studies are needed to uncover the mechanisms connecting these DNA variations to the pathogenesis of malignant diseases. Full article