The 2023 MDPI Annual Report has
been released!
 
28 pages, 7630 KiB  
Article
Efficiency Assessment on Roof Geometry and Trombe Wall Shape for Improving Buildings’ Heating Performance
by Maher Dhahri, Ahmet Yüksel, Hana Aouinet, Di Wang, Müslüm Arıcı and Habib Sammouda
Buildings 2024, 14(5), 1297; https://doi.org/10.3390/buildings14051297 (registering DOI) - 04 May 2024
Abstract
It is crucial to consider structural design issues in Trombe wall (T-wall) buildings to promote more suitable indoor climates and thermal comfort standards. Therefore, the present study examined the impact of two different T-wall designs and six different roof types on the energy [...] Read more.
It is crucial to consider structural design issues in Trombe wall (T-wall) buildings to promote more suitable indoor climates and thermal comfort standards. Therefore, the present study examined the impact of two different T-wall designs and six different roof types on the energy and operational efficiency of a building located in a low-temperature and high-humidity winter climate. Ansys-CFX 15.0 software was employed to simulate the thermal and fluid dynamics behavior of the T-wall system, and flow, thermal comfort, energy, and exergy analyses were conducted. Three-dimensional simulation results and the pertinent literature data showed a good level of agreement, and the accuracy of the model was ensured. Outcomes revealed an average air velocity variation of 0.186 m/s and maximum average indoor air temperature variation of 3.3 °C between the six roof geometries. The highest air speed (0.988 m/s) was recorded for the gambrel roof while the lowest one (0.802 m/s) was recorded for the typical flat roof. The shed roof right with a rounded T-wall was more comfortable for standing and sitting activity than the others for the two T-wall shapes, and, at Y = 0.6 m and Y = 1.1 m, the average predicted percentages of dissatisfied (PPD) values were 31 and 28%, respectively. Furthermore, it was determined in the study that solar radiation intensity and T-wall and roof geometries had a significant effect on energy and exergy efficiency, and high energy and exergy efficiencies were achieved at higher solar intensity values. The best energy and exergy efficiencies were obtained for the butterfly and shed roof configurations. This study can serve as a reference for the thermal environment design of buildings with T-walls. Full article
(This article belongs to the Section Building Structures)
7 pages, 349 KiB  
Communication
Rikkosan’s Short-Term Analgesic Effect on Burning Mouth Syndrome: A Single-Arm Cohort Study
by Tatsuki Itagaki, Keisuke Nakamura, Tougo Tanabe, Takumi Shimura, Yu Nakai, Ken-ichiro Sakata, Jun Sato and Yoshimasa Kitagawa
Biomedicines 2024, 12(5), 1013; https://doi.org/10.3390/biomedicines12051013 (registering DOI) - 04 May 2024
Abstract
Burning mouth syndrome (BMS) is a chronic oral pain disorder. There is a theory that BMS is a form of nociplastic pain. A standard treatment for BMS has not yet been established. Kampo medicine is a traditional oriental medicine. The purpose of this [...] Read more.
Burning mouth syndrome (BMS) is a chronic oral pain disorder. There is a theory that BMS is a form of nociplastic pain. A standard treatment for BMS has not yet been established. Kampo medicine is a traditional oriental medicine. The purpose of this study is to evaluate the effectiveness of Rikkosan—a traditional Japanese herbal medicine (Kampo)—in the treatment of BMS. A single-center retrospective study was conducted on 20 patients who were diagnosed with BMS and treated with Rikkosan alone (total daily dose; 7.5 g) three times daily for approximately 4 weeks (29.5 ± 6.5 days). Rikkosan was dissolved in hot water and taken internally. They had an average age of 63 years, and 90% were being treated for other illnesses, but their medication status was the same during this study period, except for Rikkosan. No adverse events were observed in patients. Numerical rating scale (NRS) or visual analog scale (VAS)/10 scores decreased significantly between the time of the initiation of Rikkosan and one month after (−2.1 ± 1.2, p < 0.05). Rikkosan has a short-term effect of reducing NRS by two levels in BMS patients. Full article
14 pages, 2253 KiB  
Article
A Highly Homogeneous Airborne Fungal Community around a Copper Open Pit Mine Reveals the Poor Contribution Made by the Local Aerosolization of Particles
by Sebastián Fuentes-Alburquenque, Victoria Olivencia Suez, Omayra Aguilera, Blanca Águila, Luis Rojas Araya and Dinka Mandakovic
Microorganisms 2024, 12(5), 934; https://doi.org/10.3390/microorganisms12050934 (registering DOI) - 04 May 2024
Abstract
Fungi are ubiquitous and metabolically versatile. Their dispersion has important scientific, environmental, health, and economic implications. They can be dispersed through the air by the aerosolization of near surfaces or transported from distant sources. Here, we tested the contribution of local (scale of [...] Read more.
Fungi are ubiquitous and metabolically versatile. Their dispersion has important scientific, environmental, health, and economic implications. They can be dispersed through the air by the aerosolization of near surfaces or transported from distant sources. Here, we tested the contribution of local (scale of meters) versus regional (kilometers) sources by analyzing an airborne fungal community by ITS sequencing around a copper mine in the North of Chile. The mine was the regional source, whereas the soil and vegetal detritus were the local sources at each point. The airborne community was highly homogeneous at ca. 2000 km2, impeding the detection of regional or local contributions. Ascomycota was the dominant phylum in the three communities. Soil and vegetal detritus communities had lower alpha diversity, but some taxa had abundance patterns related to the distance from the mine and altitude. On the contrary, the air was compositionally even and unrelated to environmental or spatial factors, except for altitude. The presence of plant pathogens in the air suggests that other distant sources contribute to this region’s airborne fungal community and reinforces the complexity of tracking the sources of air microbial communities in a real world where several natural and human activities coexist. Full article
(This article belongs to the Special Issue Airborne Microbial Communities)
29 pages, 3087 KiB  
Article
Hunting Search Algorithm-Based Adaptive Fuzzy Tracking Controller for an Aero-Pendulum
by Ricardo Rojas-Galván, José R. García-Martínez, Edson E. Cruz-Miguel, Omar A. Barra-Vázquez, Luis F. Olmedo-García and Juvenal Rodríguez-Reséndiz
Technologies 2024, 12(5), 63; https://doi.org/10.3390/technologies12050063 (registering DOI) - 04 May 2024
Abstract
The aero-pendulum is a non-linear system used broadly to develop and test new controller strategies. This paper presents a new methodology for an adaptive PID fuzzy-based tracking controller using a Hunting Search (HuS) algorithm. The HuS algorithm computes the parameters of the membership [...] Read more.
The aero-pendulum is a non-linear system used broadly to develop and test new controller strategies. This paper presents a new methodology for an adaptive PID fuzzy-based tracking controller using a Hunting Search (HuS) algorithm. The HuS algorithm computes the parameters of the membership functions of the fuzzification stage. As a novelty, the algorithm guarantees the overlap of the membership functions to ensure that all the functions are interconnected, generating new hunters to search for better solutions in the overlapping area. For the defuzzification stage, the HuS algorithm sets the singletons in optimal positions to evaluate the controller response using the centroid method. To probe the robustness of the methodology, the PID fuzzy controller algorithm is implemented in an embedded system to track the angular position of an aero-pendulum test bench. The results show that the adaptive PID fuzzy controller proposed presents root mean square error values of 0.42, 0.40, and 0.49 for 80, 90, and 100 degrees, respectively. Full article
(This article belongs to the Special Issue Smart Systems (SmaSys2023))
15 pages, 2371 KiB  
Article
Radiographic Study of Transcrestal Sinus Floor Elevation Using Osseodensification Technique with Graft Material: A Pilot Study
by Khrystyna Sulyhan-Sulyhan, Javier Barberá-Millán, Carolina Larrazábal-Morón, Julián Espinosa-Giménez and María Dolores Gómez-Adrián
Biomimetics 2024, 9(5), 276; https://doi.org/10.3390/biomimetics9050276 (registering DOI) - 04 May 2024
Abstract
This pilot study aimed to evaluate the level of implant success after transcrestal sinus floor elevation (tSFE) using the osseodensification technique (OD) combined with beta-tricalcium phosphate (β-TCP) by analyzing clinical and radiographic results. Moreover, the increase in bone height was analyzed immediately after [...] Read more.
This pilot study aimed to evaluate the level of implant success after transcrestal sinus floor elevation (tSFE) using the osseodensification technique (OD) combined with beta-tricalcium phosphate (β-TCP) by analyzing clinical and radiographic results. Moreover, the increase in bone height was analyzed immediately after surgery, 3 months after, and before loading by taking standardized radiographic measurements. Thirteen patients, four males and nine females, with a mean age of 54.69 ± 5.86 years, requiring the placement of one implant in the upper posterior maxilla, with a residual bone height of <8 mm and a minimum bone width of 5 mm, participated in the study. The bone gain data was obtained using cone-beam computed tomography (CBCT) immediately after surgery and twelve months after the placement. The correlation between initial and final bone height with implant stability was also assessed. The results were analyzed using SPSS 23 software (p < 0.05). The results of the study indicated a 100% implant success rate after a follow-up period of twelve months. Preoperative main bone height was 5.70 ± 0.95 mm. The osseodensification technique allowed a significant increase of 6.65 ± 1.06 mm immediately after surgery. After a twelve-month follow-up, a graft material contraction of 0.90 ± 0.49 mm was observed. No correlation was observed between the bone height at the different times of the study and the primary stability of the implant. Considering the limitations of the size sample of this study, the osseodensification technique used for transcrestal sinus lift with the additional bone graft material (β-TCP) may provide a predictable elevation of the maxillary sinus floor, allowing simultaneous implant insertion with adequate stability irrespective of bone height limitations. Full article
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12 pages, 2743 KiB  
Article
Plastic and Reconstructive Surgery in the Wake of the Eid al-Adha: A Single-Center, Five-Year Investigation
by Mehmet Tapan, Burak Yaşar, Hasan Murat Ergani and Süleyman Can Ceylan
J. Clin. Med. 2024, 13(9), 2704; https://doi.org/10.3390/jcm13092704 (registering DOI) - 04 May 2024
Abstract
(1) Background: The Festival of Sacrifice, commonly known as Eid al-Adha, has a profound religious and cultural impact on nations with a Muslim majority. This festival is celebrated every year in Muslim countries; however, it is a time in which patients present to [...] Read more.
(1) Background: The Festival of Sacrifice, commonly known as Eid al-Adha, has a profound religious and cultural impact on nations with a Muslim majority. This festival is celebrated every year in Muslim countries; however, it is a time in which patients present to the emergency department with serious injuries. In our study, we examined current injuries occurring during Eid al-Adha in one of the largest hospitals in Türkiye, providing the largest patient population to date. This included mapping tendon and maxillofacial injuries, a first in the literature. To the best of our knowledge, this is the largest case series of injuries sustained during Eid al-Adha. The significance of this study lies in its potential to significantly benefit patients and healthcare systems by providing reference data. (2) Methods: Patients admitted to Ankara City Hospital during Eid al-Adha between 2019 and 2023 were examined. The demographic characteristics, injury patterns, and injury sites of patients admitted on the four days of Eid al-Adha were collected and analyzed. Maxillofacial traumas during the festival were analyzed. Tendon injuries on the left hand, which is the most commonly injured body part in the literature, were mapped into a figure. To compare the change in the number of patients, a comparison was made with the number of patients in our hospital for four consecutive days 2 weeks before Eid. Statistical analysis was performed using IBM SPSS Statistics for Windows. (3) Results: A total of 610 patients, including 101 female and 509 male patients, were included in this study. A statistically significant increase (p < 0.001 for all years) in hospital admission due to injury was observed. Individuals between the ages of 30 and 40 years were the most frequently admitted patients (n = 182, 29.8%). Knife injuries were significantly more common in all patients (p < 0.001). When the total number of patients was evaluated in terms of injured areas where patients present to the emergency department, left-hand injuries were found to be significantly more common than injuries in other areas (p < 0.001 for all). The extensor pollicus longus tendon was the most commonly injured tendon among all extensor and flexor tendon injuries (n = 104). The most commonly injured tendon was the flexor tendon in zone 2 of the first finger (n = 45). This study showed that injuries to the extensor tendon in zone 1 of the fifth finger, the flexor tendon in zone 4 of the first finger, and the flexor tendon in zone 1 of the fifth finger were never seen. Twenty-five patients with maxillofacial injuries were admitted to the hospital. Orbital floor fractures were the most common type of maxillofacial injury. The anesthesia technique we preferred for all patients was local anesthesia (n = 267). Wide-awake local anesthesia no tourniquet (WALANT) was the second most preferred anesthetic technique. The number of patients who were selected in a random 4-day period for each year were compared with the number of patients who came during Eid al-Adha. The Mann–Whitney U tests revealed a significant increase in injuries on the first day of Eid al-Adha compared to non-festival days (p < 0.001). However, no significant differences were observed on the subsequent days or in the overall injury counts during the festival period (p = 0.841 for day 2, p = 0.151 for day 3, p = 0.310 for day 4). (4) Conclusions: According to this study, which is the largest known case series in the literature, the number of patients admitted to the hospital increased annually. In our study, we observed a significant increase in injuries only on the first day of Eid al-Adha compared to a randomly selected 4-day period of the same year. Left-hand extensor tendon injuries from a knife were the most common injuries in middle-aged men. The extensor pollicis longus tendon was the most commonly injured extensor tendon, with zones 3 and 4 being the most commonly affected. The flexor pollicis longus tendon was the most commonly injured flexor tendon in zone 2. During this period, patients may not only need hand surgery but also maxillofacial plastic surgery. We recommend, in addition to the indications I,n the literature that during Eid al-Adha, the WALANT technique should be widely adopted in patients where local anesthesia will be insufficient. We also recommend utilizing a diagram to manage the patient load during Eid al-Adha and prevent overburdening the healthcare system. Full article
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16 pages, 601 KiB  
Article
The Effects of Tillage and the Combined Application of Organic and Inorganic Fertilizers on the Antioxidant Enzyme Activity and Yield of Maize Leaves
by Guangming Xie, Min Liang, Pei Chen, Chang Zhang, Mingyuan Fan, Chuangyun Wang and Li Zhao
Agronomy 2024, 14(5), 968; https://doi.org/10.3390/agronomy14050968 (registering DOI) - 04 May 2024
Abstract
The aim of this study was to explore the characteristics of the combined application of organic fertilizer and inorganic fertilizer using different tillage methods to delay the senescence of maize leaves. The yield and activities of GDH, CAT, APX, GR, and GSH enzymes [...] Read more.
The aim of this study was to explore the characteristics of the combined application of organic fertilizer and inorganic fertilizer using different tillage methods to delay the senescence of maize leaves. The yield and activities of GDH, CAT, APX, GR, and GSH enzymes in maize leaves were measured at different growth stages by using two tillage methods, three organic and inorganic combined applications (P1, P2, and P3), and four control treatments. (1) During the growth period, the R + S and R treatments were P1 treatments, with the highest enzyme activities noted for GDH, CAT, APX, GR, and GSH, which were 36.79–103.22% higher than those of CK. (2) The average yield of all R + S treatments was higher than that of R treatments, and the average yield of P1 treatment was the highest under R + S, which was 13,663.79 kg hm2, which was 6.39%, 7.90%, and 14.67% higher than that of P2, P3, and CK, respectively, which was lower than that of R. The yield of P1 treatment was 2.53% higher. (3) There was a significant positive correlation between APX activity, CAT activity, GR activity, GDH activity, GSH activity, grain number per ear, ear length, and 100-grain weight of maize leaves at the grain filling stage, and a significant negative correlation between bald tip length and yield. The treatment details had the strongest enzyme activity and the highest yield when using the rotary tillage + subsoiling (R + S) P1 method, which was the most suitable tillage method and the best fertilizer ratio combination, which could be demonstrated and popularized in a large area in the dry farming area of spring maize in Shanxi Province. Full article
17 pages, 3007 KiB  
Article
Indoor Environmental Quality for Comfort Learning Environments: Case Study of Palestinian School Buildings
by Aya Baba, Isam Shahrour and Mutasim Baba
Buildings 2024, 14(5), 1296; https://doi.org/10.3390/buildings14051296 (registering DOI) - 04 May 2024
Abstract
This research evaluates the quality of the indoor environment and comfort of Palestinian public schools. The importance of this study is related to the pivotal role of indoor environmental quality (IEQ) on students’ health, well-being, and academic performance, especially in a region facing [...] Read more.
This research evaluates the quality of the indoor environment and comfort of Palestinian public schools. The importance of this study is related to the pivotal role of indoor environmental quality (IEQ) on students’ health, well-being, and academic performance, especially in a region facing significant challenges such as limited financial resources and diverse climate conditions. Unlike traditional technical evaluations, this research uses a post-occupancy evaluation (POE) methodology. This research is based on a questionnaire about classes’ indoor environment and comfort parameters, including thermal comfort, lighting, acoustics, indoor air quality, and ergonomic environment. The research focuses on students’ overall well-being, considering factors often overlooked in traditional assessments. Key findings reveal significant challenges in thermal conditions due to inadequate heating, cooling, and ventilation systems and a lack of passive thermal design. High carbon dioxide levels in classrooms due to inadequate ventilation highlight a second critical challenge. Schools also suffered from noise pollution due to the absence of noise-absorbing materials. Students expressed their satisfaction with the lighting and indoor ergonomic comfort. This research resulted in recommendations to address classrooms’ IEQ challenges, focusing on strategies to improve thermal comfort, acoustics, and indoor air quality. Full article
(This article belongs to the Section Building Energy, Physics, Environment, and Systems)
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39 pages, 2537 KiB  
Article
Multi Criteria Frameworks Using New Meta-Heuristic Optimization Techniques for Solving Multi-Objective Optimal Power Flow Problems
by Murtadha Al-Kaabi, Virgil Dumbrava and Mircea Eremia
Energies 2024, 17(9), 2209; https://doi.org/10.3390/en17092209 (registering DOI) - 04 May 2024
Abstract
This article develops two metaheuristics optimization techniques, Grey Wolf Optimizer (GWO) and Harris Hawks Optimization (HHO), to handle multi-objective optimal power flow (MOOPF) issues. Multi Objective GWO (MOGWO) and Multi Objective HHO (MOHHO) are the names of the developed techniques. By combining these [...] Read more.
This article develops two metaheuristics optimization techniques, Grey Wolf Optimizer (GWO) and Harris Hawks Optimization (HHO), to handle multi-objective optimal power flow (MOOPF) issues. Multi Objective GWO (MOGWO) and Multi Objective HHO (MOHHO) are the names of the developed techniques. By combining these optimization techniques with Pareto techniques, the non-dominated solution set can be obtained. These developed approaches are characterized by simplicity and have few control parameters. Fuel cost, emissions, real power losses, and voltage deviation were the four objective functions considered. The theories used to determine the best compromise solution and organize the Pareto front options are the fuzzy membership equation and the crowding distance approach, respectively. To validate and evaluate the performance of the presented techniques, two standard IEEE bus systems—30-bus and 57-bus power systems—were proposed. Bi, Tri, and Quad objective functions with 21 case studies are the types of objective functions and the scenarios that were applied in this paper. As compared to the results of the most recent optimization techniques documented in the literature, the comparative analysis results for the proposed methodologies demonstrated the superiority and robustness of MOGWO and MOHHO. Full article
(This article belongs to the Section F1: Electrical Power System)
20 pages, 687 KiB  
Article
Exploring Flexural Strength Variation in Polymeric Materials for Provisional Fixed Prosthetic Structures: Comparative Analysis with and without Reinforcement through Laboratory Experimentation and Statistical Evaluation
by Mariana Dimova-Gabrovska, Todor Uzunov, Angela Gusiyska, Dobromira Shopova, Iva Taneva, Ivan Gerdzhikov and Stefan Rangelov
Appl. Sci. 2024, 14(9), 3923; https://doi.org/10.3390/app14093923 (registering DOI) - 04 May 2024
Abstract
Provisional fixed partial dentures represent a critical phase in dental treatment, necessitating heightened mechanical durability, particularly in comprehensive and extended treatment plans. Strengthening these structures with various reinforcing materials offers a method to enhance their resilience. Utilizing a three-point testing methodology on standardized [...] Read more.
Provisional fixed partial dentures represent a critical phase in dental treatment, necessitating heightened mechanical durability, particularly in comprehensive and extended treatment plans. Strengthening these structures with various reinforcing materials offers a method to enhance their resilience. Utilizing a three-point testing methodology on standardized trial specimens allows for a comparative assessment of various materials and reinforcement techniques for pre-prosthetic applications. This study aims to validate and assess the significance of integrating different reinforcing materials into standardized test bodies. The study focuses on test specimens comprising three types of unreinforced laboratory and clinical polymers for provisional constructions (n = 6)—heat-cured PMMA (Superpont C+B, Spofa Dental, Czech Republic), CAD-CAM prefabricated PMMA (DD temp MED, Dental Direkt, Germany), CAD-CAM printing resin (Temporary CB Resin, FormLabs, USA), self-polymerizing PEMA (DENTALON plus, Kulzer, Germany), light-polymerizing composite (Revotek LC, GC, Japan), and dual-polymerizing composite (TempSpan, Pentron, USA). Additionally, laboratory polymers are evaluated in groups with five types of reinforcing filaments (n = 15)—Glass Fiber (Fiber Splint One-Layer, Polydentia, Switzerland), Polyethylene thread (Ribbond Regular 4.0 mm, Ribbond Inc., USA), triple-stranded chrome-cobalt wire for splinting 015″ (Leone S.p.a., Italy), Aesthetic ligature wire 012” (Leone S.p.a., Italy), and Glass Fiber coated with light-cured composite 8.5 × 0.2 mm (Interlig, Angelus, Brazil). Analysis of the data using Generalized Linear Models (GLMs) reveals that the experimental bodies, produced via the subtractive digital method using PMMA (DD temp MED, Dental Direkt GmbH, Germany) as the polymer and glass filaments as the reinforcement, exhibit superior mechanical properties, particularly when pre-wetted with Interlig liquid composite (Angelus, Brazil). Full article
(This article belongs to the Section Applied Dentistry and Oral Sciences)
23 pages, 1302 KiB  
Article
Approach for Calculating and Analyzing Carbon Emissions and Sinks of Villages: A Case Study in Northern China
by Tiantian Du, Yan Jiao, Yue Zhang, Ziyu Jia, Jueqi Wang, Jinhao Zhang and Zheng Cheng
Energies 2024, 17(9), 2212; https://doi.org/10.3390/en17092212 (registering DOI) - 04 May 2024
Abstract
Despite a gradual decline in rural population due to urbanization, as of 2022, approximately 35% of China’s total population still resides in villages. Over a span of 40 years, carbon emissions from villages have significantly surged, with a sevenfold increase from energy consumption [...] Read more.
Despite a gradual decline in rural population due to urbanization, as of 2022, approximately 35% of China’s total population still resides in villages. Over a span of 40 years, carbon emissions from villages have significantly surged, with a sevenfold increase from energy consumption and a 46% rise from agriculture. Consequentially, the development of low-carbon villages is imperative. A comprehensive understanding of the primary sources of carbon emissions in villages is crucial for implementing practical and effective strategies towards low-carbon development. However, limited research has been conducted on quantifying carbon emissions and sinks for Chinese villages. This study aims to address this gap by proposing a methodology for assessing carbon emissions in villages, including the emissions of CO2, CH4 and N2O. Inspired by the IPCC standard methodology for greenhouse gas emissions at national levels and provincial greenhouse gas inventory guidelines customized for China’s context incorporating localized characteristics, this approach has been applied to seven villages in Northern China based on field investigations. Employing a range of methods including field surveys, questionnaires, statistical records and big-data platforms, we collected the carbon emission activity levels of the seven villages using the most up-to-date carbon emission factors. Subsequently, the collected data and facts are quantitatively processed to generate results that are compared among the seven villages. These findings are also compared with those from other studies. The analysis indicates that the primary industries in these villages significantly influence the total carbon emissions. Moreover, the study reveals that energy consumption in buildings, agriculture, transportation and waste disposal are the most influential emission sources. These findings provide valuable insights into the carbon emission landscape of villages and can serve as a guide for implementing strategies and policies aimed at promoting low-carbon development in the rural areas of Northern China. Full article
(This article belongs to the Section B: Energy and Environment)
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10 pages, 1544 KiB  
Article
Design and Performance of a Low-Energy Gamma-Ray Trigger System for HERD
by Luis Fariña, Keerthana Lathika, Giulio Lucchetta, Monong Yu, Joan Boix, Laia Cardiel-Sas, Oscar Blanch, Manel Martinez and Javier Rico
Instruments 2024, 8(2), 31; https://doi.org/10.3390/instruments8020031 (registering DOI) - 04 May 2024
Abstract
The High Energy cosmic-Radiation Detection (HERD) facility has been proposed as one of the main experiments on board the Chinese space station. HERD is scheduled to be installed around 2027 and to operate for at least 10 years. Its main scientific goals are [...] Read more.
The High Energy cosmic-Radiation Detection (HERD) facility has been proposed as one of the main experiments on board the Chinese space station. HERD is scheduled to be installed around 2027 and to operate for at least 10 years. Its main scientific goals are the study of the cosmic ray spectrum and composition up to the PeV energy range, indirect dark matter detection, and all-sky gamma-ray observation above 100. HERD features a novel design in order to optimize its acceptance per weight, with a central 3D imaging calorimeter surrounded on top and on its four lateral sides by complementary subdetectors. A dedicated trigger, dubbed the ultra-low-energy gamma-ray (ULEG) trigger, is required to enable the detection of gamma rays down to 100 . The ULEG trigger design is based upon the search for energy deposition patterns on the tracker and the anticoincidence shield, compatible with the conversion of a gamma ray within the tracker volume and resulting in enough tracker hits to allow for a good-quality gamma-ray direction reconstruction. We describe the current status of the design of the ULEG trigger system. We also characterize its performance in detecting gamma rays as inferred from Monte Carlo studies. Full article
13 pages, 4010 KiB  
Article
Binuclear Dioxomolybdenum(VI) Complex Based on Bis(2-pyridinecarboxamide) Ligand as Effective Catalyst for Fuel Desulfurization
by Fátima Mirante, Catarina N. Dias, André Silva, Sandra Gago and Salete S. Balula
Catalysts 2024, 14(5), 305; https://doi.org/10.3390/catal14050305 (registering DOI) - 04 May 2024
Abstract
A binuclear dioxomolybdenum catalyst [(MoO2Cl2)2(L)] (1) (with L (1S,2S)-N,N′-bis(2-pyridinecarboxamide)-1,2-cyclohexane) was prepared and used as catalyst for the desulfurization of a multicomponent model fuel containing the most refractory [...] Read more.
A binuclear dioxomolybdenum catalyst [(MoO2Cl2)2(L)] (1) (with L (1S,2S)-N,N′-bis(2-pyridinecarboxamide)-1,2-cyclohexane) was prepared and used as catalyst for the desulfurization of a multicomponent model fuel containing the most refractory sulfur compounds in real fuels. This complex was shown to have a high efficiency to oxidize the aromatic benzothiophene derivative compounds present in fuels, mainly using a biphasic 1:1 model fuel/MeOH system. This process conciliates catalytic oxidative and extractive desulfurization, resulting in the oxidation of the sulfur compounds in the polar organic solvent. The oxidative catalytic performance of (1) was shown to be influenced by the presence of water in the system. Using 50% aq. H2O2, it was possible to reuse the catalyst and the extraction solvent, MeOH, during ten consecutive cycles without loss of desulfurization efficiency. Full article
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40 pages, 2707 KiB  
Review
Quantum Dot Research in Breast Cancer: Challenges and Prospects
by Hossein Omidian, Renae L. Wilson and Luigi X. Cubeddu
Materials 2024, 17(9), 2152; https://doi.org/10.3390/ma17092152 (registering DOI) - 04 May 2024
Abstract
The multifaceted role of quantum dots (QDs) in breast cancer research highlights significant advancements in diagnostics, targeted therapy, and drug delivery systems. This comprehensive review addresses the development of precise imaging techniques for early cancer detection and the use of QDs in enhancing [...] Read more.
The multifaceted role of quantum dots (QDs) in breast cancer research highlights significant advancements in diagnostics, targeted therapy, and drug delivery systems. This comprehensive review addresses the development of precise imaging techniques for early cancer detection and the use of QDs in enhancing the specificity of therapeutic delivery, particularly in challenging cases like triple-negative breast cancer (TNBC). The paper also discusses the critical understanding of QDs’ interactions with cancer cells, offering insights into their potential for inducing cytotoxic effects and facilitating gene therapy. Limitations such as biocompatibility, toxicity concerns, and the transition from laboratory to clinical practice are critically analyzed. Future directions emphasize safer, non-toxic QD development, improved targeting mechanisms, and the integration of QDs into personalized medicine, aiming to overcome the current challenges and enhance breast cancer management. Full article
16 pages, 2501 KiB  
Article
Pharmacologically Induced Accommodation Palsy and the Bioelectrical Activity of the Muscular System: A Preliminary Investigation
by Grzegorz Zieliński, Beata Pająk-Zielińska, Anna Woźniak, Michał Ginszt, Nicola Marchili, Piotr Gawda and Robert Rejdak
Diagnostics 2024, 14(9), 961; https://doi.org/10.3390/diagnostics14090961 (registering DOI) - 04 May 2024
Abstract
The aim of this study was to pharmacologically induce accommodative paralysis and evaluate its effects on the bioelectrical activity of the muscular system. The study included two participant groups: those with myopia and those with normal vision (emmetropes). Electromyographic assessments were performed using [...] Read more.
The aim of this study was to pharmacologically induce accommodative paralysis and evaluate its effects on the bioelectrical activity of the muscular system. The study included two participant groups: those with myopia and those with normal vision (emmetropes). Electromyographic assessments were performed using the Noraxon Ultium DTS 8-K MR 3 myo Muscle Master Edition system. The muscles analyzed in this study were the temporalis, masseter, sternocleidomastoid, trapezius, abdominal muscles, biceps brachii, and the external oblique muscles of the abdomen. It is important to acknowledge that, based on the current findings, it cannot be definitively stated that the observed effects have clinical significance, and additional studies are encouraged. Full article
(This article belongs to the Section Pathology and Molecular Diagnostics)
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19 pages, 8290 KiB  
Article
Numerical Estimation of Nonlinear Thermal Conductivity of SAE 1020 Steel
by Ariel Flores Monteiro de Oliveira, Elisan dos Santos Magalhães, Kahl Dick Zilnyk, Philippe Le Masson and Ernandes José Gonçalves do Nascimento
Computation 2024, 12(5), 92; https://doi.org/10.3390/computation12050092 (registering DOI) - 04 May 2024
Abstract
Thermally characterizing high-thermal conductivity materials is challenging, especially considering high temperatures. However, the modeling of heat transfer processes requires specific material information. The present study addresses an inverse approach to estimate the thermal conductivity of SAE 1020 relative to temperature during an autogenous [...] Read more.
Thermally characterizing high-thermal conductivity materials is challenging, especially considering high temperatures. However, the modeling of heat transfer processes requires specific material information. The present study addresses an inverse approach to estimate the thermal conductivity of SAE 1020 relative to temperature during an autogenous LASER Beam Welding (LBW) experiment. The temperature profile during LBW is computed with the aid of an in-house CUDA-C algorithm. Here, the governing three-dimensional heat diffusion equation is discretized through the Finite Volume Method (FVM) and solved using the Successive Over-Relaxation (SOR) parallelized iterative solver. With temperature information, one may employ a minimization procedure to assess thermal properties or process parameters. In this work, the Quadrilateral Optimization Method (QOM) is applied to perform estimations because it allows for the simultaneous optimization of variables with no quantity restriction and renders the assessment of parameters in unsteady states valid, thereby preventing the requirement for steady-state experiments. We extended QOM’s prior applicability to account for more parameters concurrently. In Case I, the optimization of the three parameters that compose the second-degree polynomial function model of thermal conductivity is performed. In Case II, the heat distribution model’s gross heat rate (Ω) is also estimated in addition to the previous parameters. Ω [W] quantifies the power the sample receives and is related to the process’s efficiency. The method’s suitability for estimating the parameters was confirmed by investigating the reduced sensitivity coefficients, while the method’s stability was corroborated by performing the estimates with noisy data. There is a good agreement between the reference and estimated values. Hence, this study introduces a proper methodology for estimating a temperature-dependent thermal property and an LBW parameter. As the performance of the present algorithm is increased using parallel computation, a pondered solution between estimation reliability and computational cost is achieved. Full article
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11 pages, 1597 KiB  
Article
Evaluation of miR-148a-3p and miR-106a-5p as Biomarkers for Prostate Cancer: Pilot Study
by Roxana Andra Coman, Vlad Horia Schitcu, Liviuta Budisan, Lajos Raduly, Cornelia Braicu, Bogdan Petrut, Ioan Coman, Ioana Berindan-Neagoe and Nadim Al Hajjar
Genes 2024, 15(5), 584; https://doi.org/10.3390/genes15050584 (registering DOI) - 04 May 2024
Abstract
MicroRNAs (miRNAs) are a class of small non-coding RNAs that may function as tumor suppressors or oncogenes. Alteration of their expression levels has been linked to a range of human malignancies, including cancer. The objective of this investigation is to assess the relative [...] Read more.
MicroRNAs (miRNAs) are a class of small non-coding RNAs that may function as tumor suppressors or oncogenes. Alteration of their expression levels has been linked to a range of human malignancies, including cancer. The objective of this investigation is to assess the relative expression levels of certain miRNAs to distinguish between prostate cancer (PCa) from benign prostatic hyperplasia (BPH). Blood plasma was collected from 66 patients diagnosed with BPH and 58 patients with PCa. Real-time PCR technology was used to evaluate the relative expression among the two groups for miR-106a-5p and miR-148a-3p. The significant downregulation of both miRNAs in plasma from PCa versus BPH patients suggests their potential utility as diagnostic biomarkers for distinguishing between these conditions. The concurrent utilization of these two miRNAs slightly enhanced the sensitivity for discrimination among the two analyzed groups, as shown in ROC curve analysis. Further validation of these miRNAs in larger patient cohorts and across different stages of PCa may strengthen their candidacy as clinically relevant biomarkers for diagnosis and prognosis. Full article
(This article belongs to the Special Issue Non-coding RNAs in Human Health and Disease)
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16 pages, 4950 KiB  
Article
Analysis of Mechanical Properties of Fiber-Reinforced Soil Cement Based on Kaolin
by Junnan Zhao, Zhongling Zong, Hang Cen and Pai Jiang
Materials 2024, 17(9), 2153; https://doi.org/10.3390/ma17092153 (registering DOI) - 04 May 2024
Abstract
Adding fibers into cement to form fiber-reinforced soil cement material can effectively enhance its physical and mechanical properties. In order to investigate the effect of fiber type and dosage on the strength of fiber-reinforced soil cement, polypropylene fibers (PPFs), polyvinyl alcohol fibers (PVAFs), [...] Read more.
Adding fibers into cement to form fiber-reinforced soil cement material can effectively enhance its physical and mechanical properties. In order to investigate the effect of fiber type and dosage on the strength of fiber-reinforced soil cement, polypropylene fibers (PPFs), polyvinyl alcohol fibers (PVAFs), and glass fibers (GFs) were blended according to the mass fraction of the mixture of cement and dry soil (0.5%, 1%, 1.5%, and 2%). Unconfined compressive strength tests, split tensile strength tests, scanning electron microscopy (SEM) tests, and mercury intrusion porosimetry (MIP) pore structure analysis tests were conducted. The results indicated that the unconfined compressive strength of the three types of fiber-reinforced soil cement peaked at a fiber dosage of 0.5%, registering 26.72 MPa, 27.49 MPa, and 27.67 MPa, respectively. The split tensile strength of all three fiber-reinforced soil cement variants reached their maximum at a 1.5% fiber dosage, recording 2.29 MPa, 2.34 MPa, and 2.27 MPa, respectively. The predominant pore sizes in all three fiber-reinforced soil cement specimens ranged from 10 nm to 100 nm. Furthermore, analysis from the perspective of energy evolution revealed that a moderate fiber dosage can minimize energy loss. This paper demonstrates that the unconfined compressive strength test, split tensile strength test, scanning electron microscopy (SEM), and mercury intrusion porosimetry (MIP) pore structure analysis offer theoretical underpinnings for the utilization of fiber-reinforced soil cement in helical pile core stiffening and broader engineering applications. Full article
(This article belongs to the Section Construction and Building Materials)
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21 pages, 445 KiB  
Article
Adaptive Fuzzy Fixed-Time Control for Uncertain Nonlinear Systems with Mismatched Disturbances
by Rongzheng Luo, Lu Zhang and You Li
Symmetry 2024, 16(5), 560; https://doi.org/10.3390/sym16050560 (registering DOI) - 04 May 2024
Abstract
This paper focuses on addressing the adaptive fuzzy fixed-time issue for a class of nonlinear systems with uncertainty functions and mismatched disturbances. Fuzzy logical systems are utilized for identifying unknown functions. Additionally, to tackle challenges posed by mismatched disturbances, disturbance observers are constructed [...] Read more.
This paper focuses on addressing the adaptive fuzzy fixed-time issue for a class of nonlinear systems with uncertainty functions and mismatched disturbances. Fuzzy logical systems are utilized for identifying unknown functions. Additionally, to tackle challenges posed by mismatched disturbances, disturbance observers are constructed based on the backstepping method. Utilizing the adding one power integrator approach and the fixed-time control method, this paper introduces a fixed-time adaptive fuzzy control algorithm. Notably, this algorithm accommodates the presence of unknown mismatched disturbances and nonlinear functions. The paper establishes, through the application of the Lyapunov stability theory, that the designed adaptive fixed-time fuzzy control algorithm ensures practical fixed-time stability for the resulting closed-loop systems. Finally, the effectiveness of the derived strategy is demonstrated through an illustrative example involving two cases. Full article
13 pages, 1888 KiB  
Article
Biomechanical Posture Analysis in Healthy Adults with Machine Learning: Applicability and Reliability
by Federico Roggio, Sarah Di Grande, Salvatore Cavalieri, Deborah Falla and Giuseppe Musumeci
Sensors 2024, 24(9), 2929; https://doi.org/10.3390/s24092929 (registering DOI) - 04 May 2024
Abstract
Posture analysis is important in musculoskeletal disorder prevention but relies on subjective assessment. This study investigates the applicability and reliability of a machine learning (ML) pose estimation model for the human posture assessment, while also exploring the underlying structure of the data through [...] Read more.
Posture analysis is important in musculoskeletal disorder prevention but relies on subjective assessment. This study investigates the applicability and reliability of a machine learning (ML) pose estimation model for the human posture assessment, while also exploring the underlying structure of the data through principal component and cluster analyses. A cohort of 200 healthy individuals with a mean age of 24.4 ± 4.2 years was photographed from the frontal, dorsal, and lateral views. We used Student’s t-test and Cohen’s effect size (d) to identify gender-specific postural differences and used the Intraclass Correlation Coefficient (ICC) to assess the reliability of this method. Our findings demonstrate distinct sex differences in shoulder adduction angle (men: 16.1° ± 1.9°, women: 14.1° ± 1.5°, d = 1.14) and hip adduction angle (men: 9.9° ± 2.2°, women: 6.7° ± 1.5°, d = 1.67), with no significant differences in horizontal inclinations. ICC analysis, with the highest value of 0.95, confirms the reliability of the approach. Principal component and clustering analyses revealed potential new patterns in postural analysis such as significant differences in shoulder–hip distance, highlighting the potential of unsupervised ML for objective posture analysis, offering a promising non-invasive method for rapid, reliable screening in physical therapy, ergonomics, and sports. Full article
(This article belongs to the Special Issue Sensors and Artificial Intelligence in Gait and Posture Analysis)
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26 pages, 638 KiB  
Review
A Systematic Literature Review of Predictors of Erythropoiesis-Stimulating Agent Failure in Lower-Risk Myelodysplastic Syndromes
by Ralph Boccia, Hong Xiao, Caroline von Wilamowitz-Moellendorff, Renuka Raorane, Sohan Deshpande, Sven L. Klijn and Aylin Yucel
J. Clin. Med. 2024, 13(9), 2702; https://doi.org/10.3390/jcm13092702 (registering DOI) - 04 May 2024
Abstract
Erythropoiesis-stimulating agents (ESAs) are the first-line treatment option for anemia in patients with lower-risk myelodysplastic syndromes (LR-MDS). A systematic literature review was conducted to identify evidence of the association between prognostic factors and ESA response/failure in LR-MDS. MEDLINE, Embase, and relevant conferences were [...] Read more.
Erythropoiesis-stimulating agents (ESAs) are the first-line treatment option for anemia in patients with lower-risk myelodysplastic syndromes (LR-MDS). A systematic literature review was conducted to identify evidence of the association between prognostic factors and ESA response/failure in LR-MDS. MEDLINE, Embase, and relevant conferences were searched systematically for studies assessing the association between prognostic factors and ESA response/failure in adult patients. Of 1566 citations identified, 38 were included. Patient risk status in studies published from 2000 onwards was commonly assessed using the International Prognostic Scoring System (IPSS) or revised IPSS. ESA response was generally assessed using the International Working Group MDS criteria. Among the included studies, statistically significant relationships were found, in both univariate and multivariate analyses, between ESA response and the following prognostic factors: higher hemoglobin levels, lower serum erythropoietin levels, and transfusion independence. Furthermore, other prognostic factors such as age, bone marrow blasts, serum ferritin level, IPSS risk status, and karyotype status did not demonstrate statistically significant relationships with ESA response. This systematic literature review has confirmed prognostic factors of ESA response/failure. Guidance to correctly identify patients with these characteristics could be helpful for clinicians to provide optimal treatment. Full article
(This article belongs to the Section Hematology)
13 pages, 4082 KiB  
Article
Effects of Heating Bituminous Mixtures in a Hot-Gas Drum Based on a Finite Volume Method
by Xuan Li, Haiying Cheng, Xiaohui Liu and Wenfeng Zhu
Symmetry 2024, 16(5), 559; https://doi.org/10.3390/sym16050559 (registering DOI) - 04 May 2024
Abstract
Hot-gas drum heating (HDH) of bituminous mixtures is a new approach to heating bituminous mixtures that is influenced by the parameters of the hot gas and drum. A fluid thermal numerical model was developed to evaluate the effects of heating bituminous mixtures with [...] Read more.
Hot-gas drum heating (HDH) of bituminous mixtures is a new approach to heating bituminous mixtures that is influenced by the parameters of the hot gas and drum. A fluid thermal numerical model was developed to evaluate the effects of heating bituminous mixtures with HDH using a finite-volume method (FVM). The FVM was verified through the heating test of a bituminous mixture. The effects of the drum rotating speed and hot-gas speed on the efficiency of heating the bituminous mixture during HDH were analyzed using Fluent. The results indicated that the drum rotating speed directly influenced the formation of a bituminous-mixture curtain, which had a significant effect on the efficiency of heating the bituminous mixture. The efficiency of the heat exchange between the hot gas and the bituminous mixture was high, with full contact between the hot gas and the bituminous mixture. With an increase in the hot-gas speed, the heating time became shorter; however, the rate of hot-gas utilization was reduced. A symmetrical temperature distribution and a superior heating efficiency of the bituminous mixture were achieved when the drum rotating speed was 7 rpm and the hot-gas speed was 1.4 m/s. Full article
(This article belongs to the Section Engineering and Materials)
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11 pages, 5547 KiB  
Article
Evaluating the Agreement between Oral, Armpit, and Ear Temperature Readings during Physical Activities in an Outdoor Setting
by Yuanzhe Zhao, Leonardo de Almeida e Bueno, David A. Holdsworth and Jeroen H. M. Bergmann
Int. J. Environ. Res. Public Health 2024, 21(5), 595; https://doi.org/10.3390/ijerph21050595 (registering DOI) - 04 May 2024
Abstract
Accurate body temperature measurement is essential for monitoring and managing safety during outdoor activities. Physical activities are an essential consideration for public health, with sports taking up an important proportion of these. Athletes’ performances can be directly affected by body temperature fluctuations, with [...] Read more.
Accurate body temperature measurement is essential for monitoring and managing safety during outdoor activities. Physical activities are an essential consideration for public health, with sports taking up an important proportion of these. Athletes’ performances can be directly affected by body temperature fluctuations, with overheating or hypothermia posing serious health risks. Monitoring these temperatures allows coaches and medical staff to make decisions that enhance performance and safety. Traditional methods, like oral, axillary, and tympanic readings, are widely used, but face challenges during intense physical activities in real-world environments. This study evaluated the agreement, correlation, and interchangeability of oral, axillary, and tympanic temperature measurements in outdoor exercise conditions. Systems developed for specific placements might generate different sensor readouts. Conducted as an observational field study, it involved 21 adult participants (11 males and 10 females, average age 25.14 ± 5.80 years) that underwent the Yo-Yo intermittent recovery test protocol on an outdoor court. The main outcomes measured were the agreement and correlation between temperature readings from the three methods, both before and after exercise. The results indicate poor agreement between the measurement sites, with significant deviations observed post-exercise. Although the Spearman correlation coefficients showed consistent temperature changes post-exercise across all methods, the standard deviations in the pairwise comparisons exceeded 0.67 °C. This study concluded that widely used temperature measurement methods are challenging to use during outdoor exercises and should not be considered interchangeable. This variability, especially after exercise, underscores the need for further research using gold standard temperature measurement methods to determine the most suitable site for accurate readings. Care should thus be taken when temperature screening is done at scale using traditional methods, as each measurement site should be considered within its own right. Full article
(This article belongs to the Special Issue Effect of Physical Activity on Human Fitness)
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