For high-precision positioning applications, various GNSS errors need to be mitigated, including the tropospheric error, which remains a significant error source as it can reach up to a few meters. Although some commercial GNSS correction data providers, such as the Quasi-Zenith Satellite System (QZSS) Centimeter Level Augmentation Service (CLAS), have developed real-time precise regional troposphere products, the service is available only in limited regional areas. The International GNSS Service (IGS) has provided precise troposphere correction data in TRO format post-mission, but its long latency of 1 to 2 weeks makes it unable to support real-time applications. In this work, a real-time troposphere prediction method based on the IGS post-processing products was developed using machine learning techniques to eliminate the long latency problem. The test results from tropospheric predictions over a year using the proposed method indicate that the new method can achieve a prediction accuracy (RMSE) of 2 cm, making it suitable for real-time applications. Full article

Nitrogen dioxide (NO₂) gas sensors are pivotal in upholding environmental integrity and human health, necessitating heightened sensitivity and exceptional selectivity. Despite the prevalent use of metal oxide semiconductors (MOSs) for NO₂ detection, extant solutions exhibit shortcomings in meeting practical application criteria, specifically in response, selectivity, and operational temperatures. Here, we successfully employed a facile microwave-solvothermal method to synthesize a mesoporous CeO₂/CNCs nanocomposite. This methodology entails the rapid and comprehensive dispersion of CeO₂ nanoparticles onto helical carbon nanocoils (CNCs), resulting in augmented electronic conductivity and an abundance of active sites within the composite. Consequently, the gas-sensing sensitivity of the nanocomposite at room temperature experienced a notable enhancement. Moreover, the presence of cerium oxide and the conversion of Ce³⁺ and Ce⁴⁺ ions facilitated the generation of oxygen vacancies in the composites, thereby further amplifying the sensing performance. Experimental outcomes demonstrate that the nanocomposite exhibited an approximate 9-fold increase in response to 50 ppm NO₂ in comparison to pure CNCs at room temperature. Additionally, the CeO₂/CNCs sensor displayed remarkable selectivity towards NO₂ when exposed to gases such as NH₃, CO, SO₂, CO₂, and C₂H₅OH. This straightforward microwave-solvothermal method presents an appealing strategy for the research and development of intelligent sensors based on CNCs nanomaterials. Full article

The following article examines the role of the sentidos and the entendimiento in Pedro Calderón de la Barca’s auto sacramental, El cubo de la Almudena. While scholarship recognises the pervasiveness of the play on the senses in early modern Spain, scholars often either deny or overemphasise the reliability of the senses as a means of truth acquisition. Moreover, scholarship often attaches too much weight to hearing, thus neglecting the role of the eyes of the entendimiento. Based on a Thomistic framework, Calderón demonstrates that the literal element of allegory relies on the active vehicle of the senses to serve as guides for the entendimiento and an entrance into devotion. Although hearing plays a central role in the play, it serves as a herald for sight, by which the devotee exercises faith. Moreover, where the sentidos prove limited, the entendimiento is an auxiliary support that makes up for their lack, seeing beyond sensual perception through faith. In this way, the medium of the auto sacramental and the theology of the Eucharist train the audience to use the vision of faith through both the senses and the entendimiento to see the allegorical meaning of the play, the divine nature of the Eucharist provided by Mary. Full article

P2X7 is an ATP-activated purinergic receptor implicated in pro-inflammatory responses. It is associated with the development of several diseases, including inflammatory and neurodegenerative conditions. Although several P2X7 receptor antagonists have recently been reported in the literature, none of them is approved for clinical use. However, the structure of the known antagonists can serve as a scaffold for discovering effective compounds in clinical therapy. This study aimed to propose an improved virtual screening methodology for the identification of novel potential P2X7 receptor antagonists from natural products through the combination of shape-based and docking approaches. First, a shape-based screening was performed based on the structure of JNJ-47965567, a P2X7 antagonist, using two natural product compound databases, MEGx (~5.8 × 10³ compounds) and NATx (~32 × 10³ compounds). Then, the compounds selected by the proposed shape-based model, with Shape–Tanimoto score values ranging between 0.624 and 0.799, were filtered for drug-like properties. Finally, the compounds that met the drug-like filter criteria were docked into the P2X7 allosteric binding site, using the docking programs GOLD and DockThor. The docking poses with the best score values were submitted to careful visual inspection of the P2X7 allosteric binding site. Based on our established visual inspection criteria, four compounds from the MEGx database and four from the NATx database were finally selected as potential P2X7 receptor antagonists. The selected compounds are structurally different from known P2X7 antagonists, have drug-like properties, and are predicted to interact with key P2X7 allosteric binding pocket residues, including F88, F92, F95, F103, M105, F108, Y295, Y298, and I310. Therefore, the combination of shape-based screening and docking approaches proposed in our study has proven useful in selecting potential novel P2X7 antagonist candidates from natural-product-derived compounds databases. This approach could also be useful for selecting potential inhibitors/antagonists of other receptors and/or biological targets. Full article

Rain gardens are used to solve urban problems related to the negative impact of stormwater. (1) Scientific contributions from different countries provide general guidelines for the design and operation of rain gardens in different geographical areas. Given the small spatial scale of rain gardens, the use of existing infiltration models often leads to design errors. (2) The purpose of this paper is to develop a hydrological model by introducing a system of equations that extends the ability to calculate the rate, flow rate and time of saturation of layers with moisture and rainwater leakage from the rain garden system. (3) The results obtained allow us to describe the dynamic processes of passage and saturation of layers of the rain garden at a certain point in time, which extends the ability to calculate the flow rate. It was established that the smaller the area of the rain garden compared to the area of the catchment basin, the faster it reaches its full saturation. Increasing the thickness of the rain garden layers allows for an increase in the efficiency of water retention at a lower value of the area ratio. (4) The practical significance of the results obtained is especially important for the correct description of hydrodynamics in the system and determining the optimal conditions for the effective functioning and management of the rain garden structure for any climatic region. Full article

Urban floods caused by extreme rainstorm events have increased in recent decades, particularly in concave-down bridge zones. To simulate urban flooding processes accurately, an integrated urban flood model (IUFM) was constructed by coupling a distributed urban surface runoff model based on the cellular automata framework (CA-DUSRM), a widely used pipe convergence module in the storm water management model (SWMM), with an inundation module that describes the overflow expansion process associated with terrain and land-cover. The IUFM was used in a case study of the Anhua Bridge (a typical concave-down overpass) study area in Beijing, China. The spatial-temporal variations in flood depth modeled by the IUFM were verified to be reliable by comparison with actual measurements and other simulations. The validated IUFM was used to obtain temporal variations in flood range, depth, and volume under four rainstorm scenarios (return periods of 3-year, 10-year, 50-year, and 100-year). The results showed that the surface runoff process, overflow from drainage networks, and overflow expansion process could affect the flooding status by changing the composition and spatial configuration of pervious or impervious patches, drainage capacity, and underlying surface characteristics (such as terrain and land-cover). Overall, although the simulation results from the IUFM contain uncertainties from the model structures and inputs, the IUFM is an effective tool that can provide accurate and timely information to prevent and control urban flood disasters and provide decision-making support for long-term storm water management and sponge city construction. Full article

This research emphasizes a meta-heuristic modified ant lion optimizer (MALO) optimization approach for the simultaneous utilization of DSTATCOM devices and distributed photovoltaic (PV) sources with network reconfiguration in a radial power distribution scheme. In a radial power distribution network with network reconfiguration, the majority of the research is based on constant power model analysis. However, it is noticed that load models have a substantial impact on the distributed PV sources and the DSTATCOM device’s optimal size and position. The effect of the constant power (CP) and polynomial (ZIP) with load growth load models for the simultaneous insertion of distributed PV sources and DSTATCOM devices with network reconfiguration is examined in this research work for power system planning. The penetration levels of distributed PV sources considered for the investigation are 25%, 50%, 75%, and 100%. The principal objective of this research is to reduce network total power losses, enhance the voltage magnitude profile at all buses, and reduce the overall operating cost while adhering to equality and inequality constraints. The proposed algorithm is verified on 118-node test systems. The investigation is carried out for planning network upgrading to a high-voltage distribution system (HVDS) on 317 nodes in the rural Bangalore Electricity Supply Company Limited (BESCOM) radial distribution scheme. The simulated results obtained with this method are validated with the BAT algorithm and techniques available in the literature. It is observed that in the IEEE 118-bus system, via the simultaneous placement and sizing of PV sources considering a 25% penetration level and DSTATCOM devices during network reconfiguration, the total power loss reduction is 41.47% and 42.98% for the constant power model and ZIP with the load growth model. For the 317-bus system, the total power loss reduction observed for 11 kV is 49.77% and 59.34% for the constant power model and ZIP model with load growth. Similarly, for the 22 kV system, the power loss reduction observed is 51.69% and 55.75% for the constant power model and ZIP with the load growth model. Full article

The organizational effectiveness of nonprofit organizations (NPOs) has received considerable attention from the scientific research community and society. Nonprofit scholars call for more empirical research that tests existing theories and develops multidimensional frameworks at the organizational level, with a focus on actual management practices. Previous studies have suggested that a broad set of management practices at the program and organizational levels have positive implications for the perceived effectiveness of NPOs. This study evaluates and refines a conceptual model of the antecedents of organizational effectiveness and validates its applicability in the context of charitable foundations established by corporations. Based on survey data from their executive leaders, this study’s empirical findings suggest that perceived organizational effectiveness is less affected by a broad set of management practices and is driven by a few selected best practices that focus on specific stakeholder groups (i.e., experts). Moreover, the results show that certain organizational characteristics, such as organizational experience, can strengthen the perceived effectiveness of charitable foundations. Overall, the results of this study may help nonprofit executive leaders to better understand that a careful selection and implementation of specific practices might be more beneficial for an organization’s effectiveness than an extensive list of practices. Moreover, this study contributes on a broader theoretical level to the study of multidimensional frameworks as a suitable measure for identifying key antecedents of leader-perceived organizational effectiveness across different types of NPOs. Full article

MEK inhibitors (MEKi) represent innovative and promising treatments for managing manifestations of neurofibromatosis type 1 (NF1). To mitigate potential ophthalmic side effects, such as MEKi-associated retinopathy (MEKAR), patients undergoing MEKi therapy routinely receive ophthalmology evaluations. Our study aims to assess the necessity of this regular screening within a predominantly pediatric NF1 population by examining the occurrence of ocular adverse events (OAE). A retrospective study evaluated 45 NF1 patients receiving MEKi. Inclusion criteria included baseline and follow-up examinations following the initiation of MEKi therapy. At each assessment, a comprehensive eye evaluation was performed, comprising a dilated fundus examination, ocular coherence tomography of the macula and nerve fiber layer, and Humphrey visual field testing. Twenty-six patients, with an average age of 13 years (range 2–23 years) and an average follow-up duration of 413 days were included in the analysis. Three different MEKi were used: selumetinib (77%), trametinib (23%), and mirdametinib (4%). None of the patients experienced retinopathy at any point during the study. Some patients had pre-existing optic neuropathies (27%), but no instances of nerve changes occurred after commencing MEKi therapy. Four patients (15%) exhibited symptoms of dry eye, all of which were effectively managed with topical lubrication. Full article

In the study of English denominal adjectives, scholarly attention has predominantly centred on those with Latinate suffixes (e.g., -al, -ary, and -ic/-ical), which are well-known as relational adjectives (RAdjs) and are extensively scrutinised in the existing literature. Conversely, those with English native suffixes (e.g., -en, -ern, -y, and -ed) have not undergone thorough examination to date. In the present study, I delve specifically into denominal adjectives with the suffix -ed (-ed Adjs), such as bearded, long-tailed, and shirt-sleeved. I present a novel basic picture of these adjectives, setting forth the following two central propositions: (i) -ed Adjs are a type of RAdj and (ii) undergo conversion to qualitative adjectives (QAdjs) (e.g., bearded man vs. bearded rock) akin to the better-known Latinate RAdjs (e.g., grammatical error vs. grammatical sentence). The analysis is conducted by examining suffixal etymology (i.e., Latinate or Germanic), suffixal properties (i.e., all-purpose or dedicated), and the driving factor for QAdj-forming conversion (i.e., the modal attribute true). These propositions and analyses collectively enrich our comprehensive understanding of the semantic and morphosyntactic properties of -ed Adjs within the realm of English morphology. Full article

Background: Additive manufacturing (AM) for patient-specific medical care products offers great opportunities. However, evidence about the supply chain (SC) performance impact based on empirical data is limited. Methods: In this case study, we gathered real-life data about a traditional manufacturing orthopedic shoe SC and developed future scenarios in which AM is introduced at various points and with different degrees of penetration in the SC. Results: Presently, AM can only replace traditional manufacturing of tools and shoe components at a higher total cost. However, with maturing technology, the complete AM production of orthopedic shoes is expected to become feasible. Theoretically, that could disrupt existing SCs, eliminating 70% of the SC steps, improving SC lead time by 90%, and altering SC relations. However, certain thresholds currently prevent disruption. Specifically, the AM of complete orthopedic shoes has to become possible, manufacturing prices have to drop, and traditional craftsmanship has to be integrated into the digital product design. Conclusions: A framework for transition pathways, including directions for future research, is formed. Findings provide valuable insights for scholars and decision makers in the patient-specific products industry, health insurance providers, and healthcare policy makers to be better prepared by adjusting SC designs, relationships, and remuneration programs while AM technology develops towards maturity. Full article

We studied some fibrotic aspects of chronic interstitial pneumonitis in the lungs of dogs infected with Leishmania infantum. The lungs of eleven naturally infected dogs, twelve experimentally infected with two distinct strains of L. infantum (BH401 and BH46), and six uninfected (controls) dogs, were analyzed by histological, parasitological, and immunohistochemical studies. Conventional histology (HE), collagen deposition (Gomori’s silver staining for reticulin collagen fibers), and immunohistochemistry for myofibroblast characterization were carried out based on the cellular expression of alpha-smooth muscle actin, vimentin, cytokeratin, E-cadherin, snail antigen homologue 1 (SNAI1) (Snail), and the cytokine expression of transforming growth factor-beta (TGF-β). Parasitological screening was carried out using conventional polymerase chain reaction (PCR) and the immunohistochemical reaction of streptavidin–peroxidase for visualizing Leishmania amastigotes. Dogs naturally infected with L. infantum and experimentally infected with L. infantum BH401 strains showed intense interstitial pneumonitis characterized by thickening of the alveolar septa as a consequence of an intense diffuse and focal (plaques) chronic exudate of mononuclear cells associated with fibrogenesis. The expression of alpha-actin, vimentin, and TGF-β was higher in the lung interstitium of all infected dogs than in the other two groups (BH46 strain and controls). Moreover, in both the naturally and experimentally infected dog (BH401 strain) groups, the expression of Snail was moderate to intense in contrast to the other groups. Based on these immunohistochemical results, we concluded that mesenchymal cells are active in promoting changes in the extracellular matrix in the lungs of dogs naturally and experimentally infected with L. infantum, but it depends on the virulence of the parasite. Full article

While digital twins (DTs) have recently gained prominence as a viable option for creating reliable asset representations, many existing frameworks and architectures in the literature involve the integration of different technologies and paradigms, including the Internet of Things (IoTs), data modeling, and machine learning (ML). This complexity requires the orchestration of these different technologies, often resulting in subsystems and composition frameworks that are difficult to seamlessly align. In this paper, we present a scalable compositional framework designed for the development of a DT-based production management system (PMS) with advanced production monitoring capabilities. The conducted approach used to design the compositional framework utilizes the Factory Design and Improvement (FDI) methodology. Furthermore, the validation of our proposed framework is illustrated through a case study conducted in a phosphate screening station within the context of the mining industry. Full article

Urban areas are undergoing significant changes with the rise of smart cities, with technology transforming how cities develop through enhanced connectivity and data-driven services. However, these advancements also bring new challenges, especially in dealing with urban emergencies that can disrupt city life and infrastructure. The emergency management systems have become crucial elements for enabling cities to better handle urban emergencies, although ensuring the reliability and detectability of such system remains critical. This article introduces a new method to perform reliability and detectability assessments. By using Fault Tree Markov chain models, this article evaluates their performance under extreme conditions, providing valuable insights for designing and operating urban emergency systems. These analyses fill a gap in the existing research, offering a comprehensive understanding of emergency management systems functionality in complex urban settings. Full article

With the rising popularity of fitness supplements, understanding the factors driving their consumption behaviors is crucial. This study investigated the actual consumption of fitness supplements utilizing the Theory of Planned Behavior (TPB), Health Belief Model (HBM), and the Theory of Effort Minimization in Physical Activity (TEMPA) frameworks. The TPB provided insights into how attitudes, subjective norms, and perceived behavioral control influence individuals’ intentions to consume fitness supplements. Additionally, the HBM sheds light on perceived effectiveness, benefits, barriers, and health motivation related to supplement consumption. Integrating the TEMPA framework further investigated the role of effort minimization in physical activity contexts. Through an online questionnaire, data were collected from a sample of 250 fitness supplement-consuming respondents. SEM analysis revealed significant associations between behavioral intentions and attitudes, perceived behavioral control, health motivation, and controlled precursors. However, it was seen that subjective norms, perceived effectiveness, perceived benefits, and automatic precursors were deemed insignificant. The findings contribute to a comprehensive understanding of the factors shaping actual consumption behaviors, offering valuable implications for marketers, health professionals, and policymakers seeking to promote informed and responsible supplement use among health and fitness enthusiasts. Full article

Background: Series of whole-body cryotherapy (WBC) among healthy and physically active individuals can potentially reduce inflammatory response, although exact mechanisms remain unclear. Methods: The impact of whole-body cryotherapy on inflammation modulators among 28 young males, categorized as non-training (NTR, N = 10), non-training with WBC (NTR-WBC, N = 10), and training with WBC (TR-WBC, N = 8), is investigated in this study. Over a period of eight weeks, NTR-WBC and TR-WBC subjects underwent 24 WBC treatments (−130 °C for 3 min, three times a week), examining changes in mRNA expressions of IL-1A, IL-6, IL-10, IFN-G, SIRT1, SIRT3, SOD2, GSS, and ICAM-1. Results: The received data indicate an acute inflammatory response to initial WBC (increased IL-1A, IL-6, and SIRT), with a greater effect in NTR-WBC. Subsequent sessions showed enhanced expressions of antioxidative genes in both WBC groups, particularly non-trained, suggesting improved oxidative stress adaptation. A notable decrease in ICAM-1 mRNA post-24 WBC treatments in NTR-WBC signifies a potential systemic anti-inflammatory effect. Conclusions: The findings of the study suggest that the combination of regular physical activity with WBC administered three times per week can potentially modulate inflammatory and antioxidant responses. This modulation is evidenced by changes in the expression of genes related to these processes. Full article

This study is based on the need to improve packaging sustainability in the food industry. Its aim was to assess the performance of a recyclable plastic material for semi-hard sheep’s cheese wedges packaging as an alternative to conventional non-sustainable plastic materials. Four different packaging treatments (air, vacuum, and CO₂/N₂ gas mixtures 50/50 and 80/20% (v/v)) were studied. Changes in gas headspace composition, sensory properties, cheese gross composition, weight loss, pH, colour, and texture profile were investigated at 5 ± 1 °C storage for 56 days. The sensory analysis indicated that vacuum packaging scored the worst in paste appearance and holes, and air atmosphere the worst in flavour; it was concluded that cheeses were unfit from day 14–21 onwards. Air and vacuum packaging were responsible for most of the significant changes identified in the texture profile analysis, and most of these happened in the early stages of storage. The colour parameters a* and b* differentiated the air packaging from the rest of the conditions. As in previous studies using conventional plastic materials, modified atmosphere packaging, either CO₂/N₂ 50/50 or 80/20% (v/v), was the most effective preserving technique to ensure the quality of this type of cheese when comparing air and vacuum packaging treatments. Full article

Background: Pirfenidone and Nintedanib have significantly improved the prognosis of patients with idiopathic pulmonary fibrosis (IPF), reducing mortality risk and exacerbations. This study aimed to analyze antifibrotic treatment utilization and its association with clinical outcomes (i.e., acute exacerbation or death) during 2014–2021 in newly diagnosed IPF patients, using Healthcare Utilization Databases of the Marche Region, Italy. Methods: The first 12-month adherence to antifibrotic was estimated using the Proportion of Days Covered (PDC), defining adherence as PDC ≥ 75%. State Sequence Analysis over the initial 52 weeks of treatment was used to identify adherence patterns. The role of adherence patterns on acute exacerbations/death, adjusted by demographic, clinical features, and monthly adherence after the 52-week period (time-dependent variable), was assessed with Cox regression. Results: Among 667 new IPF cases, 296 received antifibrotic prescriptions, with 62.8% being adherent in the first year. Three antifibrotic utilization patterns emerged—high adherence (37.2%), medium adherence (42.5%), and low adherence (20.3%)—with median PDCs of 95.3%, 79.5%, and 18.6%, respectively. These patterns did not directly influence three-year mortality/exacerbation probability, but sustained adherence reduced risk over time. Conclusions: Good adherence was observed in in this population-based study, emphasizing the importance of continuous antifibrotics therapy over time to mitigate adverse outcomes. Full article

This essay reads a short narrative, “Savoir” by Hélène Cixous, to describe susceptibility as a problem organized around two lines of impingement: between subject and world and between consciousness and the wayward impulses of interior life. The young girl in Cixous’s text suffers a moment of disorientation and distress one misty morning and, against presumptions of inviolability and ideals of subjective consistency, this unhappy event comes to resonate with her disappointed trust in the generosity of the world, her anxious sense of betrayal with respect to those who ought to protect her and her insecurity about her own role in this complex of associations. The frame of susceptibility thus opens up a space for Cixous’s reader and this essay to think the subject in her inconsistency and self-strangeness. Full article

Understanding pedestrian perceptions and attitudes is crucial for promoting walking as a daily transportation mode for sustainable mobility and the effective development of smart cities. Pedestrian preferences, shaped by factors such as age, gender, and urban infrastructure, play a pivotal role in travel behaviors. Based on a survey study, this paper examines the impact of individual and urban factors on pedestrian perceptions and attitudes towards walking in the cities of Bologna and Porto. Results reveal that individuals generally value short, safe, and green walking routes, appreciating walking for physical activity, cost savings, and time efficiency. Disliked aspects include adverse weather conditions and walking on inadequate sidewalks. Through carrying out Chi-square statistical analysis tests, a variety of significant correlations between individual and urban variables have been revealed on what people like or dislike about walking. For instance, males, young individuals, and students were more likely to prefer short pedestrian routes, while adults and seniors favored safe and green routes. These findings can assist urban planners in identifying factors that make walking both convenient and enjoyable and in supporting sustainable urban mobility policies. Full article

In this paper, a W-band waveguide bandpass filter with a standard fourth-order Chebyshev response is proposed based on the computer numerical control (CNC)-milling technology. The harmonics-staggered technique and orthogonal coupling method are incorporated into this waveguide filter design without increasing the complexity of the filter structure in order to suppress the intrinsic spurious responses near the passband. Furthermore, the proposed filter design maintains a simple construction, which can be conveniently fabricated using CNC milling. The fabricated waveguide filter exhibits an average insertion loss of 0.9 dB and a return loss of above 20 dB in a 3 dB fractional bandwidth (FBW) of 5.5% centered at 85 GHz. The excellent spurious suppression property can reach better than −25 dB up to 165 GHz. The wide stopband performance of the proposed W-band filter is very competitive compared with the reported waveguide filters. Full article

In this study, we have investigated the effects of Tremella fuciformis polysaccharide (TP) on the pasting, rheological, structural and in vitro digestive properties of Cyperus esculentus starch (CS). The results showed that the addition of TP significantly changed the pasting characteristics of CS, increased the pasting temperature and pasting viscosity, inhibited pasting, reduced the exudation of straight-chain starch and was positively correlated with the amount of TP added. The addition of the appropriate amount of TP could increase its apparent viscosity and enhance its viscoelasticity. The composite system of CS/TP exhibited higher short-range ordered structure and solid dense structure, which protected the crystal structure of CS, but was related to the amount of TP added. In addition, the introduction of TP not only decreased the in vitro digestion rate of CS and increased the content of slow-digestible starch (SDS) and resistant starch (RS), but also reduced the degree of digestion. Correlation studies established that TP could improve the viscoelasticity, relative crystallinity and short-range order of the CS/TP composite gel, maintain the integrity of the starch granule and crystalline structure, reduce the degree of starch pasting and strengthen the gel network structure of CS, which could help to lower the digestibility of CS. Full article