The 2023 MDPI Annual Report has
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11 pages, 2830 KiB  
Article
Research on Polar Operational Limit Assessment Risk Indexing System for Ships Operating in Seasonal Sea-Ice Covered Waters
by Jin Xu, Shuai Xu, Long Ma, Sihan Qian and Xiaowen Li
J. Mar. Sci. Eng. 2024, 12(5), 827; https://doi.org/10.3390/jmse12050827 (registering DOI) - 16 May 2024
Abstract
The Polar Operational Limit Assessment Risk Indexing System (POLARIS) has been established as a viable framework for assessing operational capabilities and associated risks in polar waters. Despite its inherent suitability for high-latitude territories, ships navigating through seasonal ice-infested waters at lower latitudes also [...] Read more.
The Polar Operational Limit Assessment Risk Indexing System (POLARIS) has been established as a viable framework for assessing operational capabilities and associated risks in polar waters. Despite its inherent suitability for high-latitude territories, ships navigating through seasonal ice-infested waters at lower latitudes also encounter critical safety, environmental, and economic issues exacerbated by the presence of ice. This necessitates a reliable and adaptable methodology that can serve as a reference for devising effective countermeasures. This study evaluated the use of POLARIS in the intricate ice conditions prevalent in the northern navigable waters (channels and anchorages) within Liaodong Bay of the Bohai Sea, located at relatively low latitudes. Using GF-4 satellite imagery, ice conditions were collected, and the POLARIS methodology was employed to calculate Risk Index Outcome (RIO) values for non-ice-strengthened vessels during the winter season of 2021–2022. The results showed that sectors 3, 4, 5, 7, 9, 10, and 11 within the northern part of Liaodong Bay exhibited a higher risk, with sectors 5 and 10 exhibiting the most significant risk, while sectors 1 and 2 demonstrated relatively lower risk levels. The concurrence of these findings with acknowledged ice patterns and local maritime practices confirms the applicability of the POLARIS methodology in saline, seasonally ice-covered seas. Notably, the combination of POLARIS with high-resolution satellite imagery facilitated a more precise and rapid assessment of ice risk, thereby enhancing situational awareness and informing decision-making processes in maritime operations under icy conditions. In addition, this study provides preliminary evidence that POLARIS is suitable for fine-scale scenarios, in addition to being applicable to sparse-scale scenarios, such as polar waters, especially with high-resolution ice data. At the same time, this study highlights the potential of POLARIS as a disaster prevention strategy and a tool for the maritime industry to address ice challenges. Full article
(This article belongs to the Section Ocean Engineering)
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10 pages, 431 KiB  
Article
Low-Protein Diet in Elderly Patients with Chronic Kidney Disease Stage 4 and 5 in Conservative Management: Focus on Sarcopenia Development
by Francesca K. Martino, Alessandra Zattarin, Chiara Cinquini, Silvia Toniazzo, Francesco Francini Pesenti, Lucia Federica Stefanelli, Martina Cacciapuoti, Elisabetta Bettin, Lorenzo A. Calò and Paolo Spinella
Nutrients 2024, 16(10), 1498; https://doi.org/10.3390/nu16101498 (registering DOI) - 16 May 2024
Abstract
Introduction: Chronic kidney disease is a degenerative and increasingly prevalent condition that includes metabolic abnormalities and is associated with a higher risk of sarcopenia. The conservative approach points primarily to controlling metabolic issues and reducing the risk of malnutrition and sarcopenia, slowing the [...] Read more.
Introduction: Chronic kidney disease is a degenerative and increasingly prevalent condition that includes metabolic abnormalities and is associated with a higher risk of sarcopenia. The conservative approach points primarily to controlling metabolic issues and reducing the risk of malnutrition and sarcopenia, slowing the progression of kidney disease. The present study aims to evaluate the effect of a low-protein diet on malnutrition and sarcopenia. Methods: A total of 45 patients (33 male and 12 female) aged over 70 with chronic kidney disease stage 4–5 in conservative management were considered. All patients had a dietary assessment and prescription of personalized low-protein dietary plans (≤0.6 g protein/kg) and a follow-up control between 4 and 6 months. In preliminary and follow-up evaluations, anthropometric data, blood examinations, body composition results, muscle strength, physical performance, and a 3-day food diary were collected. Results: In the follow-up period, a significant weight loss (p = 0.001) and a decrease in body mass index (p = 0.002) were recorded. Food diaries revealed a significant reduction in protein, sodium, potassium, and phosphorus intake (p < 0.001), with a significant reduction in urea (p < 0.001) and proteinuria (p = 0.01) without any impact on lean mass (p = 0.66). Considerable variations in adherence between food diaries and the prescribed diet were also noted. Conclusions: Providing a personalized low-protein diet led to significant benefits in a short period without worsening the patient’s nutritional status. Full article
(This article belongs to the Special Issue Malnutrition and Sarcopenia in Older Adults)
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22 pages, 1009 KiB  
Article
Motherhood, Human Trafficking, and Asylum Seeking: The Experiences and Needs of Survivor Mothers in Birthing and Postnatal Care
by Lois Bosatta, Mariana Crespi de Valldaura, Kevin Bales, Helen Spiby and Laoise Ni Bhriain
Societies 2024, 14(5), 69; https://doi.org/10.3390/soc14050069 (registering DOI) - 16 May 2024
Abstract
This article aims to illuminate the little-studied phenomenon of asylum-seeking child-bearing women in the UK, survivors of violence and human trafficking. This is a significant issue in terms of the proportion of women affected and the paucity of care and support currently available [...] Read more.
This article aims to illuminate the little-studied phenomenon of asylum-seeking child-bearing women in the UK, survivors of violence and human trafficking. This is a significant issue in terms of the proportion of women affected and the paucity of care and support currently available to them as mother survivors. This study looked to examine the frontline support services of one project to survivor mothers through two collaborating organisations, Happy Baby Community and Hestia, and how their services support mothers’ experiences of perinatal mental health, infant feeding, and the general experiences of migrant women and trafficking survivors in maternity care in the UK. Using evidence collected from semi-structured service-users’ interviews and focus groups, and an anonymous online staff survey, this article shows the types of care and support that are required to address not only the challenges faced by any new mother, but also the additional challenges experienced with trafficking and seeking asylum such as mental health, housing, and legal and access to other support. This article illustrates the many complex and inter-related challenges these women face, and the way the project meets practical, informational, emotional, appraisal, and social needs. It concludes by identifying several implications of the support provided and/or needed, which could be considered by other services or policymakers looking to meet the fundamental needs and rights of this cohort. Full article
(This article belongs to the Special Issue Human Trafficking and Human Rights)
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13 pages, 2514 KiB  
Article
Relationship between Spinal Range of Motion and Functional Tests in University Students: The Role of Demographic Factors
by Nela Tatiana Balint, Bogdan Alexandru Antohe, Huseyin Sahin Uysal, Alina Mihaela Cristuță and Marinela Rață
Healthcare 2024, 12(10), 1029; https://doi.org/10.3390/healthcare12101029 (registering DOI) - 16 May 2024
Abstract
Spinal disorders are some of the most prevalent health concerns, especially among students. Based on student demographics, this cross-sectional study evaluated the correlation between functional tests (FTs) and spinal range of motion (ROM). This study included 206 students (age = 19.85 ± 1.80 [...] Read more.
Spinal disorders are some of the most prevalent health concerns, especially among students. Based on student demographics, this cross-sectional study evaluated the correlation between functional tests (FTs) and spinal range of motion (ROM). This study included 206 students (age = 19.85 ± 1.80 years) from the Vasile Alecsandri University of Bacău. Participants’ assessments were conducted using the following tests: (i) Ott, (ii) Schober, (iii) Stibor, (iv) finger-to-floor distance, (v) lateral flexion of the cervical and lumbar spine, and (vi) flexion of the cervical spine. Correlation analyses were evaluated using the Spearman correlation coefficient analysis. The results indicated a very strong relationship between lateral flexion of the lumbar spine on the left (LFLSL) and right (LFLSR) for all departments (r = 0.85 to 0.97, p < 0.05). There was a stronger relationship between FT results and spinal ROM for physical-education-department students compared to students from other departments (n = 17, r = −0.38 to 0.93, p < 0.05). There was no statistically significant correlation between FTs and spinal ROM based on age (p > 0.05). The study results provide evidence of the primary risk factors that predispose students to postural deviations. Practitioners and physiotherapists can utilize these values as a reference for potential therapeutic interventions. Full article
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20 pages, 3502 KiB  
Review
Review on Mercury Control during Co-Firing Coal and Biomass under O2/CO2 Atmosphere
by Qiang Lyu and Fei Xin
Appl. Sci. 2024, 14(10), 4209; https://doi.org/10.3390/app14104209 (registering DOI) - 16 May 2024
Abstract
Combining biomass co-firing with oxy-fuel combustion is a promising Bioenergy with Carbon Capture and Storage (BECCS) technology. It has the potential to achieve a large-scale reduction in carbon emissions from traditional power plants, making it a powerful tool for addressing global climate change. [...] Read more.
Combining biomass co-firing with oxy-fuel combustion is a promising Bioenergy with Carbon Capture and Storage (BECCS) technology. It has the potential to achieve a large-scale reduction in carbon emissions from traditional power plants, making it a powerful tool for addressing global climate change. However, mercury in the fuel can be released into the flue gas during combustion, posing a significant threat to the environment and human health. More importantly, mercury can also cause the fracture of metal equipment via amalgamation, which is a major risk for the system. Therefore, compared to conventional coal-fired power plants, the requirements for the mercury concentration in BECCS systems are much stricter. This article reviews the latest progress in mercury control under oxy-fuel biomass co-firing conditions, clarifies the impact of biomass co-firing on mercury species transformation, reveals the influence mechanisms of various flue gas components on elemental mercury oxidation under oxy-fuel combustion conditions, evaluates the advantages and disadvantages of various mercury removal methods, and finally provides an outlook for mercury control in BECCS systems. Research shows that after biomass co-firing, the concentrations of chlorine and alkali metals in the flue gas increase, which is beneficial for homogeneous and heterogeneous mercury oxidation. The changes in the particulate matter content could affect the transformation of gaseous mercury to particulate mercury. The high concentrations of CO2 and H2O in oxy-fuel flue gas inhibit mercury oxidation, while the effects of NOx and SO2 are dual-sided. Higher concentrations of fly ash in oxy-fuel flue gas are conducive to the removal of Hg0. Additionally, under oxy-fuel conditions, CO2 and metal ions such as Fe2+ can inhibit the re-emission of mercury in WFGD systems. The development of efficient adsorbents and catalysts is the key to achieving deep mercury removal. Fully utilizing the advantages of chlorine, alkali metals, and CO2 in oxy-fuel biomass co-firing flue gas will be the future focus of deep mercury removal from BECCS systems. Full article
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9 pages, 452 KiB  
Article
What Is Behind? Impact of Pelvic Pain on Perceived Stress and Inflammatory Markers in Women with Deep Endometriosis
by Jordana Diniz Osaki and Marco Aurelio Pinho Oliveira
J. Clin. Med. 2024, 13(10), 2927; https://doi.org/10.3390/jcm13102927 (registering DOI) - 16 May 2024
Abstract
Introduction/Objectives: Endometriosis affects 10% of women worldwide. It is noteworthy that this condition is often accompanied by pelvic pain and stress. Endometriosis is a debilitating gynecological condition where tissue similar to the uterine lining grows outside the uterus, often causing significant pain and [...] Read more.
Introduction/Objectives: Endometriosis affects 10% of women worldwide. It is noteworthy that this condition is often accompanied by pelvic pain and stress. Endometriosis is a debilitating gynecological condition where tissue similar to the uterine lining grows outside the uterus, often causing significant pain and reproductive issues. We aimed to study the relationship between the intensity of pelvic pain, and stress and inflammatory markers in women with deep endometriosis. Methods: This cross-sectional study analyzed women diagnosed with deep endometriosis through imaging, surgery, and/or biopsy. We assessed pain using the Numerical Rating Scale (NRS). Stress was assessed with the Perceived Stress Scale (PSS-10) questionnaire and the serum cortisol levels. Additionally, we analyzed inflammatory markers, including C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR). Results: Fifty-two women, with an average age of 37.8 ± 6.9 years, participated in this study. Forty-four percent of these participants demonstrated high levels of stress, as indicated by scores above 26 on the PSS-10. Those categorized with “high stress” on the PSS-10 questionnaire exhibited significantly higher pain levels compared to those with “low stress” (p < 0.05). Furthermore, patients experiencing more-severe pelvic pain (pain score > 7) had notably higher serum cortisol levels. Women with intense pelvic pain (scores above 7 on the NRS) had significantly elevated serum cortisol levels (Cohen’s d = 0.72; p = 0.018). Conclusions: A positive association was found between stress levels and the intensity of pelvic pain in women with deep endometriosis, suggesting an interconnection between emotional aspects and biological responses. Full article
(This article belongs to the Special Issue Recent Advances and Clinical Outcomes of Endometriosis)
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17 pages, 7178 KiB  
Article
Facile Fabrication of Highly Efficient Chitosan-Based Multifunctional Coating for Cotton Fabrics with Excellent Flame-Retardant and Antibacterial Properties
by Yuan-Yuan Huang, Li-Ping Zhang, Xing Cao, Xin-Yu Tian and Yan-Peng Ni
Polymers 2024, 16(10), 1409; https://doi.org/10.3390/polym16101409 (registering DOI) - 16 May 2024
Abstract
Interest in the development of eco-friendly, sustainable, and convenient bio-based coatings to enhance flame retardancy and antibacterial properties in cotton fabrics is growing. In this work, chitosan was protonated at its amino groups using a method with a high atom economy using an [...] Read more.
Interest in the development of eco-friendly, sustainable, and convenient bio-based coatings to enhance flame retardancy and antibacterial properties in cotton fabrics is growing. In this work, chitosan was protonated at its amino groups using a method with a high atom economy using an equimolar amount of amino trimethylene phosphonic acid (ATMP), resulting in the fabrication of a single-component chitosan-based multifunctional coating (ATMP-CS), thereby avoiding any additional neutralization or purification steps. Cotton fabrics coated with various loads of ATMP-CS were prepared through a padding–drying–curing process. The morphology, thermal stability, mechanical properties, antibacterial properties, flame-retardant behavior, and flame-retardant mechanism of these fabrics were investigated. The coating exhibited excellent film-forming properties, and it imparted a uniform protective layer onto the surfaces of the cotton fabrics. When the load capacity reached 11.5%, the coated fabrics achieved a limiting oxygen index of 29.7% and successfully passed the VFT test. Moreover, the ATMP-CS coating demonstrated antibacterial rates against Escherichia coli and Staphylococcus aureus reaching 95.1% and 99.9%, respectively. This work presents a straightforward and gentle approach to fabricating colorless, environmentally friendly, and highly efficient fabric coatings that have potential applications in promoting the use of bio-based materials. Full article
(This article belongs to the Special Issue Green Flame-Retardant Polymer Material)
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13 pages, 6421 KiB  
Article
The Microstructure, Mechanical, and Friction-Wear Properties of Boron Carbide-Based Composites with TiB2 and SiC Formed In Situ by Reactive Spark Plasma Sintering
by Agnieszka Twardowska and Marcin Kowalski
Materials 2024, 17(10), 2379; https://doi.org/10.3390/ma17102379 (registering DOI) - 16 May 2024
Abstract
The paper presents the influence of the temperature of the sintering process on the microstructure and selected properties of boron carbide/TiB2/SiC composites obtained in situ by spark plasma sintering (SPS). The homogeneous mixture of boron carbide and 5% vol. Ti5 [...] Read more.
The paper presents the influence of the temperature of the sintering process on the microstructure and selected properties of boron carbide/TiB2/SiC composites obtained in situ by spark plasma sintering (SPS). The homogeneous mixture of boron carbide and 5% vol. Ti5Si3 micropowders were used as the initial material. Spark plasma sintering was conducted at 1700 °C, 1800 °C, and 1900 °C for 10 min after the initial pressing at 35 MPa. The heating and cooling rate was 200 °C/min. The obtained boron carbide composites were subjected to density measurement, an analysis of the chemical and phase composition, microstructure examination, and dry friction-wear tests in ball-on-disc geometry using WC as a counterpart material. The phase compositions of the produced composites differed from the composition of the initial powder mixture. Instead of titanium silicide, two new phases appeared: TiB2 and SiC. The complete disappearance of Ti5Si3 was accompanied by a decrease in the boron carbide content of the stoichiometry formula B13C2 and an increase in the content of TiB2, while the SiC content was almost constant. The relative density of the obtained boron carbide composites, as well as their hardness and resistance to wear, increased with the sintering temperature and TiB2 content. Unfortunately, the reactions occurring during sintering did not allow us to obtain composites with high density and hardness. The relative density was 76–85.2% of the theoretical one, while the Vickers hardness was in the range of 4–12 GPa. The mechanism wear of boron carbide composites tested in friction contact with WC was abrasive. The volumetric wear rate (Wv) of composites decreased with increasing sintering temperature and TiB2 content. The average value of coefficient of friction (CoF) was in the range of 0.54–0.61, i.e., it did not differ significantly from the value for B4C sinters. Full article
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15 pages, 2841 KiB  
Article
Fabrication and Characterization of Pectin Films Containing Solid Lipid Nanoparticles for Buccal Delivery of Fluconazole
by Namon Hirun, Jongjan Mahadlek, Sontaya Limmatvapirat, Pornsak Sriamornsak, Etsuo Yonemochi, Takayuki Furuishi and Pakorn Kraisit
Int. J. Mol. Sci. 2024, 25(10), 5413; https://doi.org/10.3390/ijms25105413 (registering DOI) - 16 May 2024
Abstract
Fluconazole (FZ) is a potential antifungal compound for treating superficial and systemic candidiasis. However, the use of conventional oral drug products has some limitations. The development of buccal film may be a potential alternative to oral formulations for FZ delivery. The present study [...] Read more.
Fluconazole (FZ) is a potential antifungal compound for treating superficial and systemic candidiasis. However, the use of conventional oral drug products has some limitations. The development of buccal film may be a potential alternative to oral formulations for FZ delivery. The present study involved the development of novel FZ-loaded solid lipid nanoparticles (FZ-SLNs) in pectin solutions and the investigation of their particle characteristics. The particle sizes of the obtained FZ-SLNs were in the nanoscale range. To produce pectin films with FZ-SLNs, four formulations were selected based on the small particle size of FZ-SLNs and their suitable polydispersity index. The mean particle sizes of all chosen FZ-SLNs formulations did not exceed 131.7 nm, and the mean polydispersity index of each formulation was less than 0.5. The properties of films containing FZ-SLNs were then assessed. The preparation of all FZ-SLN-loaded pectin films provided the mucoadhesive matrices. The evaluation of mechanical properties unveiled the influence of particle size variation in FZ-SLNs on the integrity of the film. The Fourier-transform infrared spectra indicated that hydrogen bonds could potentially form between the pectin-based matrix and the constituents of FZ-SLNs. The differential scanning calorimetry thermogram of each pectin film with FZ-SLNs revealed that the formulation was thermally stable and behaved in a solid state at 37 °C. According to a drug release study, a sustained drug release pattern with a burst in the initial stage for all films may be advantageous for reducing the lag period of drug release. All prepared films with FZ-SLNs provided a sustained release of FZ over 6 h. The films containing FZ-SLNs with a small particle size provided good permeability across the porcine mucosa. All film samples demonstrated antifungal properties. These results suggest the potential utility of pectin films incorporating FZ-SLNs for buccal administration. Full article
(This article belongs to the Special Issue New Perspectives of Colloids for Biological Applications)
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11 pages, 3189 KiB  
Article
Blood Coagulation-Inspired Fibrin Hydrogel for Portable Detection of Thrombin Based on Personal Glucometer
by Dan-Ni Yang, Shu-Yi Wu, Han-Yu Deng, Hao Zhang, Shan Shi and Shan Geng
Biosensors 2024, 14(5), 250; https://doi.org/10.3390/bios14050250 (registering DOI) - 16 May 2024
Abstract
As one of the biomarkers of coagulation system-related diseases, the detection of thrombin is of practical importance. Thus, this study developed a portable biosensor based on a personal glucometer for rapid detection of thrombin activity. Fibrinogen was used for the detection of thrombin, [...] Read more.
As one of the biomarkers of coagulation system-related diseases, the detection of thrombin is of practical importance. Thus, this study developed a portable biosensor based on a personal glucometer for rapid detection of thrombin activity. Fibrinogen was used for the detection of thrombin, and the assay principle was inspired by the blood coagulation process, where thrombin hydrolyzes fibrinogen to produce a fibrin hydrogel, and the amount of invertase encapsulated in the fibrin hydrogel fluctuates in accordance with the activity of thrombin in the sample solution. The quantitative assay is conducted by measuring the amount of unencapsulated invertase available to hydrolyze the substrate sucrose, and the signal readout is recorded using a personal glucometer. A linear detection range of 0–0.8 U/mL of thrombin with a limit of detection of 0.04 U/mL was obtained based on the personal glucometer sensing platform. The results of the selectivity and interference experiments showed that the developed personal glucometer sensing platform is highly selective and accurate for thrombin activity. Finally, the reliability of the portable glucometer method for rapid thrombin detection in serum samples was investigated by measuring the recovery rate, which ranged from 92.8% to 107.7%. In summary, the fibrin hydrogel sensing platform proposed in this study offers a portable and versatile means for detecting thrombin using a personal glucometer. This approach not only simplifies the detection process, but also eliminates the need for large instruments and skilled operators, and substantially reduces detection costs. Full article
(This article belongs to the Special Issue Enzyme Biosensors: Challenges and Future Perspectives)
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11 pages, 1180 KiB  
Article
Evaluation of Neuromuscular Morphometry of the Vaginal Wall Using Protein Gene Product 9.5 (Pgp 9.5) and Smooth Muscle α-Actin (Sma) in Patients with Posterior Vaginal Wall Prolapse
by Mustafa Çetin, Güven Güney, Özer Birge, Emine Arslan, Burcu Timur and Hakan Timur
Medicina 2024, 60(5), 816; https://doi.org/10.3390/medicina60050816 (registering DOI) - 16 May 2024
Abstract
Background and Objectives: This study aims to compare the neuromuscular structure of the vagina in women with posterior vaginal wall prolapse with the neuromuscular structure of the vagina in women without prolapse, to determine the difference, and to demonstrate the role of [...] Read more.
Background and Objectives: This study aims to compare the neuromuscular structure of the vagina in women with posterior vaginal wall prolapse with the neuromuscular structure of the vagina in women without prolapse, to determine the difference, and to demonstrate the role of neuromuscular structure in the physiopathology of prolapse. Materials and Methods: In this prospective study, women aged between 40 and 75 years who had not undergone any vaginal surgery and had not undergone any abdominal prolapse surgery were included. Thirty-one women diagnosed with rectocele on examination were included in the study group. Thirty-one patients who underwent vaginal intervention and hysterectomy for reasons other than rectocele (colposcopy, conization, etc.) without anterior or posterior wall prolapse were included in the control group. Biopsy material was obtained from the epithelium of the posterior wall of the vagina, including the fascia that fits the Ap point. Immunohistochemical staining with Protein Gene Product 9.5 and smooth muscle α-actin was performed in the pathology laboratory. The epithelial thickness measurement and smooth muscle density parameters obtained with these immunohistochemical stainings were compared between the two groups. The collected data were analyzed using the SPSS 23 package program. p values less than 0.05 were considered statistically significant. Results: In the control group, muscle thickness and the number of nerves per mm2 of fascia were statistically significantly higher than in the study group (p < 0.05). Conclusions: We found that smooth muscle tissue and the number of nerves per mm2 of fascia were decreased in posterior vaginal wall prolapse compared to the general population. Based on the correlation coefficients, age was the parameter that most affected the degree of prolapse, followed by parity, number of live births, and number of vaginal deliveries. Full article
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18 pages, 1799 KiB  
Review
“Oh, Dear We Are in Tribble”: An Overview of the Oncogenic Functions of Tribbles 1
by Karnika Singh, Christian A. Showalter, Heather R. Manring, Saikh Jaharul Haque and Arnab Chakravarti
Cancers 2024, 16(10), 1889; https://doi.org/10.3390/cancers16101889 (registering DOI) - 16 May 2024
Abstract
Pseudokinases are catalytically inactive proteins in the human genome that lack the ability to transfer phosphate from ATP to their substrates. The Tribbles family of pseudokinases contains three members: Tribbles 1, 2, and 3. Tribbles 1 has recently gained importance because of its [...] Read more.
Pseudokinases are catalytically inactive proteins in the human genome that lack the ability to transfer phosphate from ATP to their substrates. The Tribbles family of pseudokinases contains three members: Tribbles 1, 2, and 3. Tribbles 1 has recently gained importance because of its involvement in various diseases, including cancer. It acts as a scaffolding protein that brings about the degradation of its substrate proteins, such as C/EBPα/β, MLXIPL, and RAR/RXRα, among others, via the ubiquitin proteasome system. It also serves as an adapter protein, which sequesters different protein molecules and activates their downstream signaling, leading to processes, such as cell survival, cell proliferation, and lipid metabolism. It has been implicated in cancers such as AML, prostate cancer, breast cancer, CRC, HCC, and glioma, where it activates oncogenic signaling pathways such as PI3K-AKT and MAPK and inhibits the anti-tumor function of p53. TRIB1 also causes treatment resistance in cancers such as NSCLC, breast cancer, glioma, and promyelocytic leukemia. All these effects make TRIB1 a potential drug target. However, the lack of a catalytic domain renders TRIB1 “undruggable”, but knowledge about its structure, conformational changes during substrate binding, and substrate binding sites provides an opportunity to design small-molecule inhibitors against specific TRIB1 interactions. Full article
(This article belongs to the Special Issue Protein Kinases and Pseudokinases in Cancers)
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15 pages, 6500 KiB  
Article
Enhancing Oil–Water Flow Prediction in Heterogeneous Porous Media Using Machine Learning
by Gaocheng Feng, Kai Zhang, Huan Wan, Weiying Yao, Yuande Zuo, Jingqi Lin, Piyang Liu, Liming Zhang, Yongfei Yang, Jun Yao, Ang Li and Chen Liu
Water 2024, 16(10), 1411; https://doi.org/10.3390/w16101411 (registering DOI) - 16 May 2024
Abstract
The rapid and accurate forecasting of two-phase flow in porous media is a critical challenge in oil field development, exerting a substantial impact on optimization and decision-making processes. Although the Convolutional Long Short-Term Memory (ConvLSTM) network effectively captures spatiotemporal dynamics, its generalization in [...] Read more.
The rapid and accurate forecasting of two-phase flow in porous media is a critical challenge in oil field development, exerting a substantial impact on optimization and decision-making processes. Although the Convolutional Long Short-Term Memory (ConvLSTM) network effectively captures spatiotemporal dynamics, its generalization in predicting complex engineering problems remains limited. Similarly, although the Fourier Neural Operator (FNO) demonstrates adeptness at learning operators for solving partial differential equations (PDEs), it struggles with three-dimensional, long-term prediction. In response to these limitations, we introduce an innovative hybrid model, the Convolutional Long Short-Term Memory-Fourier Neural Operator (CL-FNO), specifically designed for the long-term prediction of three-dimensional two-phase flows. This model integrates a 3D convolutional encoder–decoder structure to extract and generate hierarchical spatial features of the flow fields. It incorporates physical constraints to enhance the model’s forecasts with robustness through the infusion of prior knowledge. Additionally, a temporal function, constructed using gated memory-forgetting mechanisms, augments the model’s capacity to analyze time series data. The efficacy and practicality of the CL-FNO model are validated using a synthetic three-dimensional case study and application to an actual reservoir model. Full article
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28 pages, 7943 KiB  
Article
Systemic Risk and Bank Networks: A Use of Knowledge Graph with ChatGPT
by Ren-Yuan Lyu, Ren-Raw Chen, San-Lin Chung and Yilu Zhou
FinTech 2024, 3(2), 274-301; https://doi.org/10.3390/fintech3020016 (registering DOI) - 16 May 2024
Abstract
In this paper, we study the networks of financial institutions using textual data (i.e., news). We draw knowledge graphs after the textual data has been processed via various natural language processing and embedding methods, including use of the most recent version of ChatGPT [...] Read more.
In this paper, we study the networks of financial institutions using textual data (i.e., news). We draw knowledge graphs after the textual data has been processed via various natural language processing and embedding methods, including use of the most recent version of ChatGPT (via OpenAI api). Our final graphs represent bank networks and further shed light on the systemic risk of the financial institutions. Financial news reflects live how financial institutions are connected, via graphs which provide information on conditional dependencies among the financial institutions. Our results show that in the year 2016, the chosen 22 top U.S. financial firms are not closely connected and, hence, present no systemic risk. Full article
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14 pages, 2502 KiB  
Article
The Function of Termicin from Odontotermes formosanus (Shiraki) in the Defense against Bacillus thuringiensis (Bt) and Beauveria bassiana (Bb) Infection
by Xiaogang Li, Mingyu Wang, Kai Feng, Hao Sun and Fang Tang
Insects 2024, 15(5), 360; https://doi.org/10.3390/insects15050360 (registering DOI) - 16 May 2024
Abstract
Odontotermes formosanus (Shiraki) is a subterranean termite species known for causing severe damage to trees and structures such as dams. During the synergistic evolution of O. formosanus with pathogenic bacteria, the termite has developed a robust innate immunity. Termicin is a crucial antimicrobial [...] Read more.
Odontotermes formosanus (Shiraki) is a subterranean termite species known for causing severe damage to trees and structures such as dams. During the synergistic evolution of O. formosanus with pathogenic bacteria, the termite has developed a robust innate immunity. Termicin is a crucial antimicrobial peptide in termites, significantly contributing to the defense against external infections. Building upon the successful construction and expression of the dsRNA-HT115 engineering strains of dsOftermicin1 and dsOftermicin2 in our laboratory, this work employs the ultrasonic breaking method to establish an inactivated dsOftermicins-HT115 technological system capable of producing a substantial quantity of dsRNA. This approach also addresses the limitation of transgenic strains which cannot be directly applied. Treatment of O. formosanus with dsOftermicins produced by this method could enhance the virulence of both Bt and Bb to the termites. This study laid the theoretical groundwork for the development of novel termite immunosuppressants and for the advancement and application of termite biological control strategies. Full article
(This article belongs to the Section Insect Pest and Vector Management)
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8 pages, 2251 KiB  
Article
Mineralization of Octacalcium Phosphate under Magnetic Field
by Wenhao He, Bingyu Xue, Qi Qian, Shenye Chen, Zhengyi Fu and Kun Wang
Crystals 2024, 14(5), 463; https://doi.org/10.3390/cryst14050463 (registering DOI) - 16 May 2024
Abstract
The mineralization of octacalcium phosphate (OCP) crystals in gel media was studied in the presence of a magnetic field. OCP crystal growth was found to be dependent on mineralization temperature, mineralization time, and the magnetic field. Higher temperatures significantly reduced the mineralization time, [...] Read more.
The mineralization of octacalcium phosphate (OCP) crystals in gel media was studied in the presence of a magnetic field. OCP crystal growth was found to be dependent on mineralization temperature, mineralization time, and the magnetic field. Higher temperatures significantly reduced the mineralization time, which is crucial for directional growth of OCP crystals. The growth of OCP crystals was accelerated by the applied magnetic field, while OCP crystals generated in the presence of a magnetic field exhibited increased length and width of oriented growth. This study provides valuable insights into the influence of mineralization factors in bioprocessing-inspired manufacturing processes. Full article
(This article belongs to the Section Mineralogical Crystallography and Biomineralization)
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11 pages, 1005 KiB  
Article
The Incidence of Thyroid Cancer in Bethesda III Thyroid Nodules: A Retrospective Analysis at a Single Endocrine Surgery Center
by Iyad Hassan, Lina Hassan, Nahed Balalaa, Mohamad Askar, Hussa Alshehhi and Mohamad Almarzooqi
Diagnostics 2024, 14(10), 1026; https://doi.org/10.3390/diagnostics14101026 (registering DOI) - 16 May 2024
Abstract
Background: Fine-needle aspiration cytology (FNAC) is widely used to diagnose and monitor thyroid nodules. The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) is the standard for interpreting FNAC specimens. The risk of malignancy in Bethesda III nodules, also known as Atypia of Undetermined [...] Read more.
Background: Fine-needle aspiration cytology (FNAC) is widely used to diagnose and monitor thyroid nodules. The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) is the standard for interpreting FNAC specimens. The risk of malignancy in Bethesda III nodules, also known as Atypia of Undetermined Significance (AUS), varies significantly throughout several studies published worldwide. This retrospective study examines the risk of cancer in thyroid FNAC categorized as Bethesda III as identified in the final histopathology of thyroidectomy specimens at a single endocrine surgery center. Methods: This retrospective cohort analysis included 1038 consecutive patients who underwent elective thyroid surgery with complete follow-up data between January 2020 and March 2024. Preoperative data on clinical and pathological characteristics have been collected. The final histopathology report from the thyroidectomy specimen was compared to the results of the preoperative FNAC on nodules that were judged to be Bethesda category III. Statistical methods were performed using SPSS version 29. Results: A total of 670 ultrasound-guided FNACs (64.5%) performed during the study period were included in the final analysis. The study population was predominantly female, represented by 79.6% of patients with a mean age of 42.5 (SD 12.1), while 20.4% were male and significantly older with mean age of 45.13 years (p = 0.02). The FNAC inadequacy rate was 5.1%, which was associated with a high risk of malignancy (6 out of 34; 17.6%). Out of the total sample size of 170 patients classified as group III, 57 were found to have malignancies in final surgical histopathology, representing 33.5% of the cases within this category. The secondary gender-related outcome analysis showed that female patients classified under the Bethesda II category had a significantly higher risk of malignancy, with a rate of 21.2%, compared to males who had a malignancy rate of 3.4% in the same Bethesda category (p = 0.001, chi-square test). However, the female patients exhibited prognostically superior non-invasive tumors compared to male individuals (p = 0.02, chi-square test). Conclusion: This study’s results indicate that Bethesda categories II and III are associated with a higher risk of malignancy in comparison to the reports of the first and third editions of the TBSRTC, particularly for female patients classified under category II. Full article
(This article belongs to the Special Issue Cyto-Histological Correlations in Pathology Diagnosis)
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14 pages, 1195 KiB  
Article
Acute Kidney Injury in the Context of COVID-19: An Analysis in Hospitalized Mexican Patients
by Juan Carlos Borrego-Moreno, María Julieta Cárdenas-de Luna, José Carlos Márquez-Castillo, José Manuel Reyes-Ruiz, Juan Fidel Osuna-Ramos, Moisés León-Juárez, Rosa María del Ángel, Adrián Rodríguez-Carlos, Bruno Rivas-Santiago, Carlos Noe Farfan-Morales, Ana Cristina García-Herrera and Luis Adrián De Jesús-González
Infect. Dis. Rep. 2024, 16(3), 458-471; https://doi.org/10.3390/idr16030034 (registering DOI) - 16 May 2024
Abstract
During the COVID-19 pandemic, a considerable proportion of patients developed a severe condition that included respiratory failure, shock, or multiple organ dysfunction. Acute Kidney Injury (AKI) has been recognized as a possible cause of severe COVID-19 development. Given this, this study investigates the [...] Read more.
During the COVID-19 pandemic, a considerable proportion of patients developed a severe condition that included respiratory failure, shock, or multiple organ dysfunction. Acute Kidney Injury (AKI) has been recognized as a possible cause of severe COVID-19 development. Given this, this study investigates the occurrence and consequences of AKI in Mexican patients to contribute to better knowledge and management of this problem. Methods: Using a retrospective observational cohort methodology, we investigated 313 cases from a cohort of 1019 patients diagnosed with COVID-19 at the IMSS Zacatecas General Hospital of Zone No. 1 in 2020. The prevalence of AKI was determined using the AKIN criteria based on serum creatinine levels and a detailed review of demographic characteristics, medical history, comorbidities, and clinical development. Results: The data showed a 25.30% prevalence of AKI among patients infected with severe COVID-19. Remarkably, these patients with AKI exhibited an advanced age (>65 years), arterial hypertension, a higher number of white blood cells during admission and the hospital stay, and elevated levels of C-reactive protein, serum creatinine, and blood urea nitrogen (BUN). Clinically, patients with AKI had signs of prostration, pneumonia, and the requirement for ventilatory assistance when compared to those without AKI. Finally, those diagnosed with AKI and COVID-19 had a 74% death rate. Relative risk analyses indicated that age (>65 years), arterial hypertension, high creatinine levels, endotracheal intubation, and pneumonia are associated with the development of AKI. On the other hand, among the protective factors against AKI, high hemoglobin levels and the consumption of statins during COVID-19 were found. Conclusions: The findings of this study underscore the significance of promptly identifying and effectively managing AKI to potentially alleviate the negative consequences of this complication within the Mexican population during COVID-19. Full article
(This article belongs to the Section Infection Prevention and Control)
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13 pages, 4092 KiB  
Article
Photoperiod-Dependent Nutrient Accumulation in Rice Cultivated in Plant Factories: A Comparative Metabolomic Analysis
by Jingyao Yu, Yu Yang, Lanjun Luo, Fang Feng, Sana Saeed, Jie Luo, Chuanying Fang, Junjie Zhou and Kang Li
Foods 2024, 13(10), 1544; https://doi.org/10.3390/foods13101544 (registering DOI) - 16 May 2024
Abstract
Plant factories offer a promising solution to some of the challenges facing traditional agriculture, allowing for year-round rapid production of plant-derived foods. However, the effects of conditions in plant factories on metabolic nutrients remain to be explored. In this study, we used three [...] Read more.
Plant factories offer a promising solution to some of the challenges facing traditional agriculture, allowing for year-round rapid production of plant-derived foods. However, the effects of conditions in plant factories on metabolic nutrients remain to be explored. In this study, we used three rice accessions (KongYu131, HuangHuaZhan, and Kam Sweet Rice) as objectives, which were planted in a plant factory with strict photoperiods that are long-day (12 h light/12 h dark) or short-day (8 h light/16 h dark). A total of 438 metabolites were detected in the harvested rice grains. The difference in photoperiod leads to a different accumulation of metabolites in rice grains. Most metabolites accumulated significantly higher levels under the short-day condition than the long-day condition. Differentially accumulated metabolites were enriched in the amino acids and vitamin B6 pathway. Asparagine, pyridoxamine, and pyridoxine are key metabolites that accumulate at higher levels in rice grains harvested from the short-day photoperiod. This study reveals the photoperiod-dependent metabolomic differences in rice cultivated in plant factories, especially the metabolic profiling of taste- and nutrition-related compounds. Full article
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11 pages, 376 KiB  
Article
Prognostic Value of Fibrosis 4 (FIB-4) Index in Sepsis Patients
by Tuna Albayrak and Beyza Yuksel
J. Pers. Med. 2024, 14(5), 531; https://doi.org/10.3390/jpm14050531 (registering DOI) - 16 May 2024
Abstract
Background: Sepsis remains a major health challenge worldwide, characterized by a dysregulated host response to infection, leading to high mortality and morbidity in intensive care units (ICUs). The Fibrosis 4 (FIB-4) index, originally developed to assess liver fibrosis in hepatitis C patients, has [...] Read more.
Background: Sepsis remains a major health challenge worldwide, characterized by a dysregulated host response to infection, leading to high mortality and morbidity in intensive care units (ICUs). The Fibrosis 4 (FIB-4) index, originally developed to assess liver fibrosis in hepatitis C patients, has recently been explored for its potential prognostic value in sepsis patients. Method: this study retrospectively analyzed 309 sepsis patients admitted to the Internal Medicine and An-aesthesia ICUs between 12 December 2021 and 15 December 2023 to investigate the relationship between FIB-4 levels, the Acute Physiology and Chronic Health Evaluation (APACHE), the Sequential Organ Failure Assessment (SOFA), and clinical outcomes. Results: This study found that higher FIB-4 measurements were statistically significantly associated with increased 28-day mortality, with a cut-off value of 4.9, providing a sensitivity of 54.92% and specificity of 74.25%. Logistic regression analysis indicated that elevated FIB-4 levels were a significant predictor of early mortality, suggesting that the FIB-4 index could serve as a valuable prognostic tool in assessing the severity and prognosis of sepsis patients. Conclusions: by elucidating the potential role of the FIB-4 index in sepsis prognosis, this study contributes to the ongoing efforts to improve risk stratification and enhance patient care in sepsis management. Full article
(This article belongs to the Special Issue Personalized Medicine in the ICU—2nd Edition)
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18 pages, 252 KiB  
Article
Integrating Climate Change Risks and Sustainability Goals into Saudi Arabia’s Financial Regulation: Pathways to Green Finance
by Mohammad Omar Alhejaili
Sustainability 2024, 16(10), 4159; https://doi.org/10.3390/su16104159 (registering DOI) - 16 May 2024
Abstract
This study examines the integration of climate change risks and sustainability goals within Saudi Arabia’s financial regulatory framework to enhance green finance initiatives aligned with Vision 2030. A qualitative research design synthesises insights from a comprehensive literature review, semi-structured interviews with domain experts, [...] Read more.
This study examines the integration of climate change risks and sustainability goals within Saudi Arabia’s financial regulatory framework to enhance green finance initiatives aligned with Vision 2030. A qualitative research design synthesises insights from a comprehensive literature review, semi-structured interviews with domain experts, and a detailed analysis of critical Saudi green finance frameworks and legislation. This research identifies mechanisms for embedding sustainability in the financial sector and addresses the challenges, opportunities, and strategic directions essential for Saudi Arabia within the global context of sustainable finance. The findings reveal a robust foundation laid by Vision 2030 initiatives yet underscore the need for enhanced regulatory frameworks, increased market readiness, and greater societal engagement. This study highlights a significant literature gap in understanding Saudi Arabia’s unique approach to green finance amid its economic diversification and sustainability goals. Contributing to original insights, this research underscores the critical role of Saudi Arabia in the global energy market and its substantial economic and environmental transformations. It offers detailed analyses and recommendations that enrich the discourse on sustainable finance, impacting policymakers, financial practitioners, and scholars. Full article
(This article belongs to the Special Issue Green Finance, Economics and SDGs)
8 pages, 557 KiB  
Review
The Influence of Behavioral Sciences on Adherence to Physical Activity and Weight Loss in Overweight and Obese Patients: A Systematic Review of Randomized Controlled Trials
by Rafael Corrêa and Benjamin Miranda Tabak
Int. J. Environ. Res. Public Health 2024, 21(5), 630; https://doi.org/10.3390/ijerph21050630 (registering DOI) - 16 May 2024
Abstract
In recent years, weight gain and reduced physical activity in the general population have contributed to the development of obesity and other health problems; on the other hand, studies in behavioral sciences have been used to modify behaviors for a healthier life, so [...] Read more.
In recent years, weight gain and reduced physical activity in the general population have contributed to the development of obesity and other health problems; on the other hand, studies in behavioral sciences have been used to modify behaviors for a healthier life, so the objective of this study was to identify the evidence of interventions in behavioral sciences on adherence to physical activity and weight loss in obese patients. This systematic review study is based on a search of the electronic databases PubMed, Web of Science, Scopus, and Cochrane. Studies assessed the evidence from intervention studies that assessed the influence of intervention studies of behavioral sciences on public health. The articles were published between 2013 and 2023. The systematic search of the databases identified 2951 articles. The review analyzed 10 studies. Behavioral science interventions presented evidence through strategies such as multicomponent interventions, lottery and financial incentives, message framing, message framing with financial incentive and physical activity, and psychological satisfaction, demonstrating results in weight loss and maintenance and increased physical activity. This study presents scientific evidence through healthy behavior change methodologies, and future studies can explore these strategies in conjunction with public health technologies in the search for public–private partnerships to promote physical activity in adults. Full article
(This article belongs to the Special Issue Exercise and Physical Activity in Health Promotion)
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16 pages, 521 KiB  
Article
“I Thought It Was Beautiful; I Just Wish I Could Understand It”: The Awkward Dance of Multilingual Worship
by Marcell Silva Steuernagel
Religions 2024, 15(5), 611; https://doi.org/10.3390/rel15050611 (registering DOI) - 16 May 2024
Abstract
This article explores strategies for planning and leading multilingual worship. It offers an overview of translation and multilingualism for readers unfamiliar with the growing body of scholarship in these fields and connects them to the role of translation and multilingualism in Christian worship, [...] Read more.
This article explores strategies for planning and leading multilingual worship. It offers an overview of translation and multilingualism for readers unfamiliar with the growing body of scholarship in these fields and connects them to the role of translation and multilingualism in Christian worship, leveraging decolonial perspectives to critique its history. This article draws from a data set of approximately 40 liturgies designed for the Course of Study School of the United Methodist Church at Perkins School of Theology, Southern Methodist University. It uses selections from these liturgies to demonstrate how issues of translation and multilingualism might be dealt with in worship planning and leadership. Finally, the article points to possibilities for further exploration at the intersection between Christian worship and multilingualism. Full article
(This article belongs to the Special Issue Multilingualism in Religious Musical Practice)
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