The 2023 MDPI Annual Report has
been released!
 
18 pages, 4067 KiB  
Article
LSTM-Autoencoder Deep Learning Model for Anomaly Detection in Electric Motor
by Fadhila Lachekhab, Messouada Benzaoui, Sid Ahmed Tadjer, Abdelkrim Bensmaine and Hichem Hamma
Energies 2024, 17(10), 2340; https://doi.org/10.3390/en17102340 (registering DOI) - 13 May 2024
Abstract
Anomaly detection is the process of detecting unusual or unforeseen patterns or events in data. Many factors, such as malfunctioning hardware, malevolent activities, or modifications to the data’s underlying distribution, might cause anomalies. One of the key factors in anomaly detection is balancing [...] Read more.
Anomaly detection is the process of detecting unusual or unforeseen patterns or events in data. Many factors, such as malfunctioning hardware, malevolent activities, or modifications to the data’s underlying distribution, might cause anomalies. One of the key factors in anomaly detection is balancing the trade-off between sensitivity and specificity. Balancing these trade-offs requires careful tuning of the anomaly detection algorithm and consideration of the specific domain and application. Deep learning techniques’ applications, such as LSTMs (long short-term memory algorithms), which are autoencoders for detecting an anomaly, have garnered increasing attention in recent years. The main goal of this work was to develop an anomaly detection solution for an electrical machine using an LSTM-autoencoder deep learning model. The work focused on detecting anomalies in an electrical motor’s variation vibrations in three axes: axial (X), radial (Y), and tangential (Z), which are indicative of potential faults or failures. The presented model is a combination of the two architectures; LSTM layers were added to the autoencoder in order to leverage the LSTM capacity for handling large amounts of temporal data. To prove the LSTM efficiency, we will create a regular autoencoder model using the Python programming language and the TensorFlow machine learning framework, and compare its performance with our main LSTM-based autoencoder model. The two models will be trained on the same database, and evaluated on three primary points: training time, loss function, and MSE anomalies. Based on the obtained results, it is clear that the LSTM-autoencoder shows significantly smaller loss values and MSE anomalies compared to the regular autoencoder. On the other hand, the regular autoencoder performs better than the LSTM, comparing the training time. It appears then, that the LSTM-autoencoder presents a superior performance although it was slower than the standard autoencoder due to the complexity of the added LSTM layers. Full article
(This article belongs to the Section F5: Artificial Intelligence and Smart Energy)
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18 pages, 9774 KiB  
Article
Investigating Material Performance in Artificial Ankle Joints: A Biomechanical Study
by Hasan Mhd Nazha, Muhsen Adrah, Thaer Osman, Mohammad Issa, Ahmed Imran, Yicha Zhang and Daniel Juhre
Prosthesis 2024, 6(3), 509-526; https://doi.org/10.3390/prosthesis6030036 (registering DOI) - 13 May 2024
Abstract
This study delves into an in-depth examination of the biomechanical characteristics of various materials commonly utilized in the fabrication of artificial ankle joints. Specifically, this research focuses on the design of an ankle joint resembling the salto-talaris type, aiming to comprehensively understand its [...] Read more.
This study delves into an in-depth examination of the biomechanical characteristics of various materials commonly utilized in the fabrication of artificial ankle joints. Specifically, this research focuses on the design of an ankle joint resembling the salto-talaris type, aiming to comprehensively understand its performance under different loading conditions. Employing advanced finite element analysis techniques, this investigation rigorously evaluates the stresses and displacements experienced by the designed ankle joint when subjected to varying loads. Furthermore, this study endeavors to identify the vibrating frequencies associated with these displacements, offering valuable insights into the dynamic behavior of the ankle joint. Notably, the analysis extends to studying random frequencies across three axes of motion, enabling a comprehensive assessment of directional deformities that may arise during joint function. To validate the effectiveness of the proposed design, a comparative analysis is conducted against the star ankle design, a widely recognized benchmark in ankle joint prosthetics. This comparative approach serves dual purposes: confirming the accuracy of the findings derived from the salto-talaris design and elucidating the relative efficacy of the proposed design in practical application scenarios. Full article
(This article belongs to the Special Issue Recent Advances in Foot Prosthesis and Orthosis)
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22 pages, 3025 KiB  
Article
GHSR Deletion in β-Cells of Male Mice: Ineffective in Obesity, but Effective in Protecting against Streptozotocin-Induced β-Cell Injury in Aging
by Hye Won Han, Geetali Pradhan, Daniel Villarreal, Da Mi Kim, Abhishek Jain, Akhilesh Gaharwar, Yanan Tian, Shaodong Guo and Yuxiang Sun
Nutrients 2024, 16(10), 1464; https://doi.org/10.3390/nu16101464 (registering DOI) - 13 May 2024
Abstract
Insulin secretion from pancreatic β cells is a key pillar of glucose homeostasis, which is impaired under obesity and aging. Growth hormone secretagogue receptor (GHSR) is the receptor of nutrient-sensing hormone ghrelin. Previously, we showed that β-cell GHSR regulated glucose-stimulated insulin secretion (GSIS) [...] Read more.
Insulin secretion from pancreatic β cells is a key pillar of glucose homeostasis, which is impaired under obesity and aging. Growth hormone secretagogue receptor (GHSR) is the receptor of nutrient-sensing hormone ghrelin. Previously, we showed that β-cell GHSR regulated glucose-stimulated insulin secretion (GSIS) in young mice. In the current study, we further investigated the effects of GHSR on insulin secretion in male mice under diet-induced obesity (DIO) and streptozotocin (STZ)-induced β-cell injury in aging. β-cell-specific-Ghsr-deficient (Ghsr-βKO) mice exhibited no glycemic phenotype under DIO but showed significantly improved ex vivo GSIS in aging. We also detected reduced insulin sensitivity and impaired insulin secretion during aging both in vivo and ex vivo. Accordingly, there were age-related alterations in expression of glucose transporter, insulin signaling pathway, and inflammatory genes. To further determine whether GHSR deficiency affected β-cell susceptibility to acute injury, young, middle-aged, and old Ghsr-βKO mice were subjected to STZ. We found that middle-aged and old Ghsr-βKO mice were protected from STZ-induced hyperglycemia and impaired insulin secretion, correlated with increased expression of insulin signaling regulators but decreased pro-inflammatory cytokines in pancreatic islets. Collectively, our findings indicate that β-cell GHSR has a major impact on insulin secretion in aging but not obesity, and GHSR deficiency protects against STZ-induced β-cell injury in aging. Full article
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37 pages, 2184 KiB  
Article
Dynamics of Vortex Structures: From Planets to Black Hole Accretion Disks
by Elizabeth P. Tito and Vadim I. Pavlov
Dynamics 2024, 4(2), 357-393; https://doi.org/10.3390/dynamics4020021 (registering DOI) - 13 May 2024
Abstract
Thermo-vortices (bright spots, blobs, swirls) in cosmic fluids (planetary atmospheres, or even black hole accretion disks) are sometimes observed as clustered into quasi-symmetrical quasi-stationary groups but conceptualized in models as autonomous items. We demonstrate—using the (analytical) Sharp Boundaries Evolution Method and a generic [...] Read more.
Thermo-vortices (bright spots, blobs, swirls) in cosmic fluids (planetary atmospheres, or even black hole accretion disks) are sometimes observed as clustered into quasi-symmetrical quasi-stationary groups but conceptualized in models as autonomous items. We demonstrate—using the (analytical) Sharp Boundaries Evolution Method and a generic model of a thermo-vorticial field in a rotating “thin” fluid layer in a spacetime that may be curved or flat—that these thermo-vortices may be not independent but represent interlinked parts of a single, coherent, multi-petal macro-structure. This alternative conceptualization may influence the designs of numerical models and image-reconstruction methods. Full article
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22 pages, 8212 KiB  
Article
A Semantic Spatial Structure-Based Loop Detection Algorithm for Visual Environmental Sensing
by Xina Cheng, Yichi Zhang, Mengte Kang, Jialiang Wang, Jianbin Jiao, Le Dong and Licheng Jiao
Remote Sens. 2024, 16(10), 1720; https://doi.org/10.3390/rs16101720 (registering DOI) - 13 May 2024
Abstract
Loop closure detection is an important component of the Simultaneous Localization and Mapping (SLAM) algorithm, which is utilized in environmental sensing. It helps to reduce drift errors during long-term operation, improving the accuracy and robustness of localization. Such improvements are sorely needed, as [...] Read more.
Loop closure detection is an important component of the Simultaneous Localization and Mapping (SLAM) algorithm, which is utilized in environmental sensing. It helps to reduce drift errors during long-term operation, improving the accuracy and robustness of localization. Such improvements are sorely needed, as conventional visual-based loop detection algorithms are greatly affected by significant changes in viewpoint and lighting conditions. In this paper, we present a semantic spatial structure-based loop detection algorithm. In place of feature points, robust semantic features are used to cope with the variation in the viewpoint. In consideration of the semantic features, which are region-based, we provide a corresponding matching algorithm. Constraints on semantic information and spatial structure are used to determine the existence of loop-back. A multi-stage pipeline framework is proposed to systematically leverage semantic information at different levels, enabling efficient filtering of potential loop closure candidates. To validate the effectiveness of our algorithm, we conducted experiments using the uHumans2 dataset. Our results demonstrate that, even when there are significant changes in viewpoint, the algorithm exhibits superior robustness compared to that of traditional loop detection methods. Full article
(This article belongs to the Special Issue Remote Sensing Cross-Modal Research: Algorithms and Practices)
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17 pages, 804 KiB  
Article
A C0 Nonconforming Virtual Element Method for the Kirchhoff Plate Obstacle Problem
by Bangmin Wu and Jiali Qiu
Axioms 2024, 13(5), 322; https://doi.org/10.3390/axioms13050322 (registering DOI) - 13 May 2024
Abstract
This paper investigates a novel C0 nonconforming virtual element method (VEM) for solving the Kirchhoff plate obstacle problem, which is described by a fourth-order variational inequality (VI) of the first kind. In our study, we distinguish our approach by introducing new internal [...] Read more.
This paper investigates a novel C0 nonconforming virtual element method (VEM) for solving the Kirchhoff plate obstacle problem, which is described by a fourth-order variational inequality (VI) of the first kind. In our study, we distinguish our approach by introducing new internal degrees of freedom to the traditional lowest-order C0 nonconforming VEM, which originally lacked such degrees. This addition not only facilitates error estimation but also enhances its intuitiveness. Importantly, our novel C0 nonconforming VEM naturally satisfies the constraints of the obstacle problem. We then establish an a priori error estimate for our novel C0 nonconforming VEM, with the result indicating that the lowest order of our method achieves optimal convergence. Finally, we present a numerical example to validate the theoretical result. Full article
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10 pages, 263 KiB  
Article
Factors Affecting Autistic Students’ School Motivation
by Chandra Lebenhagen and Jaclyn Dynia
Educ. Sci. 2024, 14(5), 527; https://doi.org/10.3390/educsci14050527 (registering DOI) - 13 May 2024
Abstract
Very little identifiable research explores the factors impacting autistic students’ school motivation and how these factors may or may not affect their academic and well-being outcomes in secondary school and beyond, including post-secondary enrollment, employment, and their quality of life. Instead, research on [...] Read more.
Very little identifiable research explores the factors impacting autistic students’ school motivation and how these factors may or may not affect their academic and well-being outcomes in secondary school and beyond, including post-secondary enrollment, employment, and their quality of life. Instead, research on autism and inclusive education mainly focuses on the efficacy of interventions aimed at teaching skills related to sensory, communication, social, and behavior. Methods: A secondary analysis of survey data from an original mixed-method study was conducted to investigate how environmental, teacher, and peer factors are associated with autistic students’ school motivation. Eligible participants were between the ages of 15 and 21. In total, 72 participants (n = 72) completed an online survey to share their perspectives on their school experiences. Subsequently, linear regression analysis was conducted to answer the research question. Results: Participants who rated their schools as having pleasant physical spaces and felt that their peers understood them as a person had higher levels of school motivation. Teachers were not found to be significantly related to students’ school motivation. Participants who shared that typing was their preferred mode of communication were less motivated to attend school than students who preferred speaking communication. Conclusions: Environmental and peer factors are related to more than the day-to-day school experiences of autistic students; they are also related to their school motivation. These findings add to the existing literature on inclusive education and positive school outcomes for autistic students and offer additional explanations of the barriers that affect autistic students’ graduation from secondary school and interest in attending post-secondary education. Full article
10 pages, 1249 KiB  
Article
Mortality in Community-Acquired Sepsis and Infections in the Faroe Islands—A Prospective Observational Study
by Marija Todorovic Markovic, Mirjana Todorovic Mitic, Aleksandra Ignjatovic, Magnús Gottfredsson and Shahin Gaini
Infect. Dis. Rep. 2024, 16(3), 448-457; https://doi.org/10.3390/idr16030033 (registering DOI) - 13 May 2024
Abstract
The aim of this study was to collect data and analyze mortality among patients hospitalized with community-acquired infections in the Faroe Islands. A prospective observational study was conducted in the Medical Department of the National Hospital of the Faroe Islands from October 2013 [...] Read more.
The aim of this study was to collect data and analyze mortality among patients hospitalized with community-acquired infections in the Faroe Islands. A prospective observational study was conducted in the Medical Department of the National Hospital of the Faroe Islands from October 2013 to April 2015. Cumulative all-cause, in-hospital, short-term, intermediate-term and long-term mortality rates were calculated. Kaplan–Meier survival curves comparing infection-free patients with infected patients of all severities and different age groups are presented. A log-rank test was used to compare groups. Mortality hazard ratios were calculated for subgroups using Cox regression multivariable models. There were 1309 patients without infection and 755 patients with infection. There were 51% female and 49% male patients. Mean age was 62.73 ± 19.71. Cumulative all-cause mortality and in-hospital mortality were highest in more severe forms of infection. This pattern remained the same for short-term mortality in the model adjusted for sex and age, while there were no significant differences among the various infection groups in regard to intermediate- or long-term survival after adjustment. Overall and short-term mortality rates were highest among those with severe manifestations of infection and those with infection compared to infection-free patients. Full article
(This article belongs to the Section Bacterial Diseases)
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12 pages, 2331 KiB  
Article
Evolution of Core Stability, Athletic Performance, and ACL Injury Risk across a Soccer Season
by Théo A. Weber, Youri Duchene, Frédéric R. Simon, Guillaume Mornieux and Gerôme C. Gauchard
Appl. Sci. 2024, 14(10), 4116; https://doi.org/10.3390/app14104116 (registering DOI) - 13 May 2024
Abstract
Soccer athletic performance varies across a soccer season due to training and fatigue. In addition, it is known that core stability is linked with anterior cruciate ligament (ACL) injury risk but their variations over a season are unknown. The aim of the study [...] Read more.
Soccer athletic performance varies across a soccer season due to training and fatigue. In addition, it is known that core stability is linked with anterior cruciate ligament (ACL) injury risk but their variations over a season are unknown. The aim of the study was to determine the evolution of core stability, athletic performance, and ACL injury risk among young high-level soccer players at four key moments of a season: pre-season (PRE), start of season (START), mid-season (MID), and the end of the season (END). Core stability scores increased until mid-season, while ACL injury risk scores (measured during sidestep cuttings and single-leg landing) decreased thanks to an injury prevention program between START and MID. These results are in line with the literature, which demonstrates that a high level of core stability is linked to a low injury risk. Evolution of athletic performance was not consistent throughout the season, being dependent on the specific phases of training performed by the athletes. Therefore, assessing core stability, athletic performance, and ACL injury risk multiple times across a soccer season could help coaches to adapt their training programs properly. Full article
(This article belongs to the Special Issue Advances in the Biomechanics of Sports)
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17 pages, 6377 KiB  
Article
The Effects of Pigeage, Délestage, Remontage and Oxygenation Treatments Applied during Maceration on Phenolic Content, Aroma Composition and Sensory Properties of Red Teran (Vitis vinifera L.) Wine
by Marina Tomašević, Katarina Perić, Kristijan Damijanić, Mario Staver, Natka Ćurko and Karin Kovačević Ganić
Fermentation 2024, 10(5), 252; https://doi.org/10.3390/fermentation10050252 (registering DOI) - 13 May 2024
Abstract
The aim of this study was to evaluate the effects of mechanical (pigeage, délestage and remontage) and oxygenation treatments on the phenolic and aromatic compounds and sensory characteristics of Teran wines. The experiment included a 20-day maceration period, during which the above-mentioned treatments [...] Read more.
The aim of this study was to evaluate the effects of mechanical (pigeage, délestage and remontage) and oxygenation treatments on the phenolic and aromatic compounds and sensory characteristics of Teran wines. The experiment included a 20-day maceration period, during which the above-mentioned treatments were applied, as well as the post-fermentation processes of pressing and first rack. The analysis of phenolic, chromatic and aroma compounds and the sensory characterization of the wines were used to describe the effects of the treatments investigated. After the observed maceration period, remontage resulted in wines with the highest total phenols (2682.0 ± 14.8 mg GAE/L). In contrast, délestage resulted in the lowest total phenols (2499.1 ± 17.6 mg GAE/L) and total anthocyanins (530.1 ± 2.8 mg/L) and had the strongest effects on chromatic characteristics. The post-fermentation processes (pressing, racking) showed similar trends and resulted in higher phenolic concentrations in the remontage wine, while the délestage was again characterized by lower total phenol and anthocyanin concentrations. In addition, the délestage wine contained a higher concentration of almost all analyzed esters and two higher alcohols (2-methylpropan-1-ol and 1-hexanol), while the remontage wine had the highest concentration of 2-phenylethanol and 3-methylbutyl acetate. Finally, maceration proved to be a key factor in defining the wines’ sensory characteristics, with the remontage-treated wine showing the best overall quality. Full article
(This article belongs to the Special Issue Management of Grape Phenolic Extraction in Wine Production)
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12 pages, 4736 KiB  
Review
Ocular Manifestation in Systemic Sclerosis—A Literature Review
by Katarzyna Paczwa, Magdalena Rerych, Katarzyna Romanowska-Próchnicka, Radosław Różycki and Joanna Gołębiewska
Life 2024, 14(5), 627; https://doi.org/10.3390/life14050627 (registering DOI) - 13 May 2024
Abstract
Systemic sclerosis (SSc) is a chronic autoimmune connective tissue disease that affects more than 2 million people worldwide. It manifests through vasculopathy, an abnormal immunological response, and fibrosis leading to dysfunction of the multiple organs. The disease is categorized into two subtypes: limited [...] Read more.
Systemic sclerosis (SSc) is a chronic autoimmune connective tissue disease that affects more than 2 million people worldwide. It manifests through vasculopathy, an abnormal immunological response, and fibrosis leading to dysfunction of the multiple organs. The disease is categorized into two subtypes: limited cutaneous SSc and diffuse cutaneous SSc. Scleroderma can affect vital organs with respiratory, cardiac, renal, ocular, and dermatological complications. The ocular manifestations of the disease can occur in the anterior and posterior segments of the eye. Changes in the anterior segment related to the disease include eyelid skin remodeling, dry eye syndrome, and conjunctival abnormalities. The disease’s impact on the posterior segment of the eye mostly causes pathologies in the retinal microcirculatory system and abnormalities in the optic nerve. This review provides detailed insights into ocular complications associated with scleroderma. Full article
(This article belongs to the Special Issue Eye Manifestations of Systemic Disease, 2nd Edition)
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22 pages, 2639 KiB  
Article
Crowd Counting in Diverse Environments Using a Deep Routing Mechanism Informed by Crowd Density Levels
by Abdullah N Alhawsawi, Sultan Daud Khan and Faizan Ur Rehman
Information 2024, 15(5), 275; https://doi.org/10.3390/info15050275 (registering DOI) - 13 May 2024
Abstract
Automated crowd counting is a crucial aspect of surveillance, especially in the context of mass events attended by large populations. Traditional methods of manually counting the people attending an event are error-prone, necessitating the development of automated methods. Accurately estimating crowd counts across [...] Read more.
Automated crowd counting is a crucial aspect of surveillance, especially in the context of mass events attended by large populations. Traditional methods of manually counting the people attending an event are error-prone, necessitating the development of automated methods. Accurately estimating crowd counts across diverse scenes is challenging due to high variations in the sizes of human heads. Regression-based crowd-counting methods often overestimate counts in low-density situations, while detection-based models struggle in high-density scenarios to precisely detect the head. In this work, we propose a unified framework that integrates regression and detection models to estimate the crowd count in diverse scenes. Our approach leverages a routing strategy based on crowd density variations within an image. By classifying image patches into density levels and employing a Patch-Routing Module (PRM) for routing, the framework directs patches to either the Detection or Regression Network to estimate the crowd count. The proposed framework demonstrates superior performance across various datasets, showcasing its effectiveness in handling diverse scenes. By effectively integrating regression and detection models, our approach offers a comprehensive solution for accurate crowd counting in scenarios ranging from low-density to high-density situations. Full article
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14 pages, 2614 KiB  
Article
Fecal Microbial Communities of Nellore and Crossbred Beef Calves Raised at Pasture
by José Antônio Bessegatto, Júlio Augusto Naylor Lisbôa, Bruna Parapinski Santos, Juliana Massitel Curti, Carlos Montemor, Amauri Alcindo Alfieri, Núria Mach and Marcio Carvalho Costa
Animals 2024, 14(10), 1447; https://doi.org/10.3390/ani14101447 (registering DOI) - 13 May 2024
Abstract
This study aimed to investigate the effect of age and genetics on the fecal microbiota of beef calves. Ten purebred Nellore (Bos taurus indicus) and ten crossbreed 50% Nellore-50% European breed (Bos taurus taurus) calves co-habiting on the same [...] Read more.
This study aimed to investigate the effect of age and genetics on the fecal microbiota of beef calves. Ten purebred Nellore (Bos taurus indicus) and ten crossbreed 50% Nellore-50% European breed (Bos taurus taurus) calves co-habiting on the same pasture paddock had fecal samples collected on days five (5 d), 14 d, 28 d, 60 d, 90 d, 180 d, 245 d (weaning) and 260 d after birth. All calves were kept with their mothers, and six Nellore dams were also sampled at weaning. Microbiota analysis was carried out by amplification of the V4 region of the 16S rRNA gene following high-throughput sequencing with a MiSeq Illumina platform. Results revealed that bacterial richness increased with age and became more similar to adults near weaning. Differences in microbiota membership between breeds were found at 60 d and 90 d and for structure at 60 d, 90 d, 245 d, and 260 d (p < 0.05). In addition, crossbreed calves presented less variability in their microbiota. In conclusion, the genetic composition significantly impacted the distal gut microbiota of calves co-habiting in the same environment, and further studies investigating food intake can reveal possible associations between microbiota composition and performance. Full article
(This article belongs to the Section Cattle)
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16 pages, 7151 KiB  
Article
A Response Surface Methodological Approach for Large-Scale Production of Antibacterials from Lactiplantibacillus plantarum with Potential Utility against Foodborne and Orthopedic Infections
by Paulpandian Prema, Daoud Ali, Van-Huy Nguyen, Bhathini Vaikuntavasan Pradeep, Veeramani Veeramanikandan, Maria Daglia, Carla Renata Arciola and Paulraj Balaji
Antibiotics 2024, 13(5), 437; https://doi.org/10.3390/antibiotics13050437 (registering DOI) - 13 May 2024
Abstract
A variety of bacteria, including beneficial probiotic lactobacilli, produce antibacterials to kill competing bacteria. Lactobacilli secrete antimicrobial peptides (AMPs) called bacteriocins and organic acids. In the food industry, bacteriocins, but even whole cell-free supernatants, are becoming more and more important as bio-preservatives, while, [...] Read more.
A variety of bacteria, including beneficial probiotic lactobacilli, produce antibacterials to kill competing bacteria. Lactobacilli secrete antimicrobial peptides (AMPs) called bacteriocins and organic acids. In the food industry, bacteriocins, but even whole cell-free supernatants, are becoming more and more important as bio-preservatives, while, in orthopedics, bacteriocins are introducing new perspectives in biomaterials technologies for anti-infective surfaces. Studies are focusing on Lactiplantibacillus plantarum (previously known as Lactobacillus plantarum). L. plantarum exhibits great phenotypic versatility, which enhances the chances for its industrial exploitation. Importantly, more than other lactobacilli, it relies on AMPs for its antibacterial activity. In this study, Response Surface Methodology (RSM) through a Box–Behnken experimental design was used to estimate the optimal conditions for the production of antibacterials by L. plantarum. A temperature of 35 °C, pH 6.5, and an incubation time of 48 h provided the highest concentration of antibacterials. The initial pH was the main factor influencing the production of antibacterials, at 95% confidence level. Thanks to RSM, the titer of antibacterials increased more than 10-fold, this result being markedly higher than those obtained in the very few studies that have so far used similar statistical methodologies. The Box–Behnken design turned out to be a valid model to satisfactorily plan a large-scale production of antibacterials from L. plantarum. Full article
(This article belongs to the Special Issue Development and Biomedical Application of Antibacterial Coatings)
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24 pages, 374 KiB  
Article
Laozi’s Ecofeminist Ethos: Bridging Ancient Wisdom with Contemporary Gender and Environmental Justice
by Pinghua Liu
Religions 2024, 15(5), 599; https://doi.org/10.3390/rel15050599 (registering DOI) - 13 May 2024
Abstract
This paper delves into the convergence of Laozi’s Daoist mysticism with the principles of ecofeminism, highlighting the potential for ancient wisdom to inform contemporary issues of gender and environmental justice. Through an examination of the Dao De Jing, we uncover insights into [...] Read more.
This paper delves into the convergence of Laozi’s Daoist mysticism with the principles of ecofeminism, highlighting the potential for ancient wisdom to inform contemporary issues of gender and environmental justice. Through an examination of the Dao De Jing, we uncover insights into a holistic approach to social justice that integrates ecological sustainability and gender equality. Laozi’s teachings, characterized by the principles of Dao, Wu-wei, and Ziran, offer a foundational framework for understanding the interconnectedness of all beings and the importance of living in harmony with the natural world. By analyzing relevant passages and concepts from the Dao De Jing, this paper demonstrates how Daoist philosophy aligns with and enriches ecofeminist values, advocating for a society that honors the balance between humanity and nature and recognizes the integral role of women in achieving environmental and social harmony. This paper presents case studies that illustrate the practical application of Daoist principles in ecological feminist practices, shedding light on the successes and challenges of integrating ancient philosophical insights into modern activism. The fusion of Daoist mysticism and ecofeminism provides a compelling vision for addressing the intertwined challenges of gender inequality and environmental degradation, suggesting pathways toward a more just, sustainable, and harmonious world. In doing so, it calls for a reimagined approach to social justice that is deeply informed by an understanding of ecological sustainability and gender equality as mutually reinforcing goals. Full article
(This article belongs to the Special Issue Mysticism and Social Justice)
20 pages, 559 KiB  
Article
Predictors of Adopting a Sustainability Policy in Museums
by Izabela Luiza Pop, Diana Sabina Ighian, Rita Monica Toader and Rada Florina Hahn
Sustainability 2024, 16(10), 4062; https://doi.org/10.3390/su16104062 (registering DOI) - 13 May 2024
Abstract
This paper aims to identify certain factors that may influence museums’ success in adopting and implementing a sustainability policy. The research hypotheses were formulated based on an in-depth study of the literature and subsequently tested using classical linear regression methodology. The empirical research [...] Read more.
This paper aims to identify certain factors that may influence museums’ success in adopting and implementing a sustainability policy. The research hypotheses were formulated based on an in-depth study of the literature and subsequently tested using classical linear regression methodology. The empirical research is based on 86 Romanian national questionnaires collected in October and November 2016, which tracked museums’ self-reported sustainability practices. To examine the relationships between sustainability policy and independent variables, we developed three generalized linear regression models. Our results revealed that environmental behavior and some components of social responsibility (heritage exposure and community involvement) have a positive impact on implementing sustainability policies and principles within museums. Surprisingly, economic performance did not prove to have a significant influence on sustainability policy, suggesting that financial autonomy, efficiency, and productivity are not essential elements in fostering a sustainable mindset within museums. The developed models serve as valuable tools for museum managers, providing guidance in adopting appropriate managerial decisions to achieve sustainability goals. Furthermore, the empirical research offers new insights that enhance and advance current knowledge and research in the field of sustainable management in museums. Full article
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16 pages, 9267 KiB  
Article
Ag-Incorporated Cr-Doped BaTiO3 Aerogel toward Enhanced Photocatalytic Degradation of Methyl Orange
by Jun Wu, Gaofeng Shao, Xiaodong Wu, Sheng Cui and Xiaodong Shen
Nanomaterials 2024, 14(10), 848; https://doi.org/10.3390/nano14100848 (registering DOI) - 13 May 2024
Abstract
A novel Cr-doped BaTiO3 aerogel was successfully synthesized using a co-gelation technique that involves two metallic alkoxides and a supercritical drying method. This freshly prepared aerogel has a high specific surface area of over 100 m2/g and exhibits improved responsiveness [...] Read more.
A novel Cr-doped BaTiO3 aerogel was successfully synthesized using a co-gelation technique that involves two metallic alkoxides and a supercritical drying method. This freshly prepared aerogel has a high specific surface area of over 100 m2/g and exhibits improved responsiveness to the simulated sunlight spectrum. Methyl orange (MO) was chosen as the simulated pollutant, and the results reveal that the Cr-doped BaTiO3 aerogel, when modified with the noble metal silver (Ag), achieves a pollutant removal rate approximately 3.2 times higher than that of the commercially available P25, reaching up to 92% within 60 min. The excellent photocatalytic performance of the Ag-modified Cr-doped BaTiO3 aerogel can be primarily attributed to its extensive specific surface area and three-dimensional porous architecture. Furthermore, the incorporation of Ag nanoparticles effectively suppresses the recombination of photo-generated electrons and holes. Stability and reusability tests have confirmed the reliability of the Ag-modified Cr-doped BaTiO3 aerogel. Therefore, this material emerges as a highly promising candidate for the treatment of textile wastewater. Full article
(This article belongs to the Special Issue Nanomaterials in Aerogel Composites)
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4 pages, 161 KiB  
Editorial
Antibiotic Use in Communities
by Timo J. Lajunen
Antibiotics 2024, 13(5), 438; https://doi.org/10.3390/antibiotics13050438 (registering DOI) - 13 May 2024
Abstract
Since their discovery and clinical introduction in the 1930s–1940s, penicillin and sulphonamides have had a profound impact on public health [...] Full article
(This article belongs to the Special Issue Feature Papers in Antibiotic Use in the Communities)
10 pages, 237 KiB  
Article
Understanding Pharmacy Students’ Preparedness towards Counseling over Cannabis Use Disorder
by Sourab Ganna, Jerusha Daggolu and Sujit S. Sansgiry
Pharmacy 2024, 12(3), 77; https://doi.org/10.3390/pharmacy12030077 (registering DOI) - 13 May 2024
Abstract
The rise in cannabis use prompts significant concerns regarding pharmacy students’ abilities to counsel patients over cannabis use disorder. This study aims to understand pharmacy students’ preparedness to counsel patients with cannabis use disorder (CUD) and evaluate the relationship between knowledge, attitudes towards [...] Read more.
The rise in cannabis use prompts significant concerns regarding pharmacy students’ abilities to counsel patients over cannabis use disorder. This study aims to understand pharmacy students’ preparedness to counsel patients with cannabis use disorder (CUD) and evaluate the relationship between knowledge, attitudes towards medical cannabis (MC) and recreational cannabis (RC), and behavior intention (BI) to counsel over CUD. A cross-sectional survey was administered to pharmacy students. Descriptive analyses of sample characteristics were assessed with the t-test and one-way ANOVA test. Pearson correlation and linear regression were conducted, measuring the strength and direction of relationships. The average scores for knowledge, attitudes towards MC use and RC, and behavioral intention were 81% (SD 16%), 4.13 (SD 0.75), 3.28 (0.80), and 2.74 (1.00). Significant correlations were observed between knowledge–attitudes toward MC, knowledge–attitudes towards RC, and attitudes towards RC–behavioral intentions. Linear regression indicated attitudes towards MC use and RC, academic year, awareness of MC use legality, obtained knowledge, and past patient interaction were significantly associated with behavioral intention on confidence in counseling over CUD. There is a gap in students’ behavioral intention to counsel. These findings emphasize the importance of ample preparation that enables student pharmacists to address patient needs related to cannabis use confidently. Full article
16 pages, 23035 KiB  
Article
Porcospino Flex: A Bio-Inspired Single-Track Robot with a 3D-Printed, Flexible, Compliant Vertebral Column
by Shahab Edin Nodehi, Luca Bruzzone, Mohammadreza Lalegani Dezaki, Ali Zolfagharian and Mahdi Bodaghi
Robotics 2024, 13(5), 76; https://doi.org/10.3390/robotics13050076 (registering DOI) - 13 May 2024
Abstract
This paper is focused on the design and development of the Porcospino Flex, a single-track robot inspired by nature and featuring a meta-material structure. In the earlier version of the Porcospino, the main body was composed of a chain of vertebrae and two [...] Read more.
This paper is focused on the design and development of the Porcospino Flex, a single-track robot inspired by nature and featuring a meta-material structure. In the earlier version of the Porcospino, the main body was composed of a chain of vertebrae and two end sections linked by flexible joints, but the excessive use of materials in 3D printing and the resulting weight of the robot posed challenges, ultimately leading to a decrease in its overall efficiency and performance. The Porcospino Flex is manufactured through the fused deposition modeling process using acrylonitrile butadiene styrene and thermoplastic polyurethane, featuring a singular meta-material structure vertebral column. The adoption of a lattice structure in the main body of the Porcospino Flex leads to a substantial increase in performance, reducing its weight from 4200 g to 3600 g. Furthermore, the decrease in weight leads to a reduction in material usage and waste, making a substantial contribution to the sustainability of the robot. The discussion focuses on the testing results of the Porcospino Flex prototype, highlighting the enhancements observed compared to its prior version. Full article
(This article belongs to the Special Issue Bio-Inspired Service Robots)
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14 pages, 1859 KiB  
Article
Breast Cancer Prevention by Dietary Polyphenols: Microemulsion Formulation and In Vitro Studies
by Ghea Putri Cristy, Desy Liana, Jaruwan Chatwichien, Chanat Aonbangkhen, Chantragan Srisomsap and Anuchit Phanumartwiwath
Sci. Pharm. 2024, 92(2), 25; https://doi.org/10.3390/scipharm92020025 (registering DOI) - 13 May 2024
Abstract
Concerns surrounding breast cancer have been increasing, as it leads to the current global cancer incidence and causes a high mortality rate in women. This study investigated the physiological effects of common dietary polyphenols that might prevent breast cancer progression. Quercetin, kaempferol, and [...] Read more.
Concerns surrounding breast cancer have been increasing, as it leads to the current global cancer incidence and causes a high mortality rate in women. This study investigated the physiological effects of common dietary polyphenols that might prevent breast cancer progression. Quercetin, kaempferol, and rosmarinic acid were selected to explore their potential bioactivities. Each polyphenol was formulated into a microemulsion to improve its bioactivity and bioavailability. In vitro antioxidant and cytotoxicity activities of the selected polyphenols and their microemulsion forms were further investigated. The optimized microemulsion carrier with 1% oleic acid, 3% ethanol, 10% polysorbate 20, and 86% ultrapure water achieved more than 90% polyphenol encapsulation efficiency. The microemulsion was stable for more than 30 days when encapsulating polyphenol in the fluctuating temperature treatment. In vitro studies suggested that rosmarinic acid-loaded microemulsion had the best antioxidant activity compared with other polyphenol-loaded microemulsions (PL-MEs). Blank microemulsion and all PL-MEs significantly inhibited the proliferation of both hormone-dependent (T47D) and hormone-independent (MDA-MB-231) breast cancer cells. More studies are warranted to confirm the contribution of the microemulsion carrier components to the polyphenols’ improved antioxidant activity and high toxicity of PL-MEs on breast cancer cells. Full article
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42 pages, 3774 KiB  
Review
Oxidative Stress in Breast Cancer: A Biochemical Map of Reactive Oxygen Species Production
by Lyudmila V. Bel’skaya and Elena I. Dyachenko
Curr. Issues Mol. Biol. 2024, 46(5), 4646-4687; https://doi.org/10.3390/cimb46050282 (registering DOI) - 13 May 2024
Abstract
This review systematizes information about the metabolic features of breast cancer directly related to oxidative stress. It has been shown those redox changes occur at all levels and affect many regulatory systems in the human body. The features of the biochemical processes occurring [...] Read more.
This review systematizes information about the metabolic features of breast cancer directly related to oxidative stress. It has been shown those redox changes occur at all levels and affect many regulatory systems in the human body. The features of the biochemical processes occurring in breast cancer are described, ranging from nonspecific, at first glance, and strictly biochemical to hormone-induced reactions, genetic and epigenetic regulation, which allows for a broader and deeper understanding of the principles of oncogenesis, as well as maintaining the viability of cancer cells in the mammary gland. Specific pathways of the activation of oxidative stress have been studied as a response to the overproduction of stress hormones and estrogens, and specific ways to reduce its negative impact have been described. The diversity of participants that trigger redox reactions from different sides is considered more fully: glycolytic activity in breast cancer, and the nature of consumption of amino acids and metals. The role of metals in oxidative stress is discussed in detail. They can act as both co-factors and direct participants in oxidative stress, since they are either a trigger mechanism for lipid peroxidation or capable of activating signaling pathways that affect tumorigenesis. Special attention has been paid to the genetic and epigenetic regulation of breast tumors. A complex cascade of mechanisms of epigenetic regulation is explained, which made it possible to reconsider the existing opinion about the triggers and pathways for launching the oncological process, the survival of cancer cells and their ability to localize. Full article
(This article belongs to the Special Issue Targeting Tumor Microenvironment for Cancer Therapy, 2nd Edition)
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14 pages, 2529 KiB  
Article
Reducing Methane Emissions with Humic Acid–Iron Complex in Rice Cultivation: Impact on Greenhouse Gas Emissions and Rice Yield
by Hyoung-Seok Lee, Hyo-Suk Gwon, Sun-Il Lee, Hye-Ran Park, Jong-Mun Lee, Do-Gyun Park, So-Ra Lee, So-Hyeon Eom and Taek-Keun Oh
Sustainability 2024, 16(10), 4059; https://doi.org/10.3390/su16104059 (registering DOI) - 13 May 2024
Abstract
Methane emissions from flooded rice paddies are a major source of atmospheric methane and represent a significant greenhouse gas with high climate-forcing potential due to anthropogenic activities globally. For sustainable agriculture, it is necessary to find effective methods for mitigating greenhouse gas emissions [...] Read more.
Methane emissions from flooded rice paddies are a major source of atmospheric methane and represent a significant greenhouse gas with high climate-forcing potential due to anthropogenic activities globally. For sustainable agriculture, it is necessary to find effective methods for mitigating greenhouse gas emissions without reducing crop productivity. We investigated mechanisms to reduce methane emissions during rice cultivation by applying rice straw, rice husk biochar, humic acid, and a humic acid–iron complex, assessing greenhouse gases and rice yield over a single season. The results demonstrated that the treatment plots with rice straw and the humic acid–iron complex significantly reduced methane emissions (563 ± 113.9 kg ha−1) by 34.4% compared to plots treated with rice straw alone (859 ± 126.4 kg ha−1). Rice yield was not compromised compared to the control group treated with only NPK fertilizer, and growth in terms of plant height and tiller number was enhanced in the plots treated with rice straw and the humic acid–iron complex. Conversely, the plots treated solely with rice husk biochar and humic acid did not show a methane reduction effect when compared to the NPK treatment. The humic acid–iron complex has demonstrated potential as a methane mitigation agent with practical applicability in the field, warranting further long-term studies to validate its effectiveness. Full article
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