The 2023 MDPI Annual Report has
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Article
Index Air Quality Monitoring for Light and Active Mobility
by Stefano Botticini, Elisabetta Comini, Salvatore Dello Iacono, Alessandra Flammini, Luigi Gaioni, Andrea Galliani, Luca Ghislotti, Paolo Lazzaroni, Valerio Re, Emiliano Sisinni, Matteo Verzeroli and Dario Zappa
Sensors 2024, 24(10), 3170; https://doi.org/10.3390/s24103170 (registering DOI) - 16 May 2024
Abstract
Light and active mobility, as well as multimodal mobility, could significantly contribute to decarbonization. Air quality is a key parameter to monitor the environment in terms of health and leisure benefits. In a possible scenario, wearables and recharge stations could supply information about [...] Read more.
Light and active mobility, as well as multimodal mobility, could significantly contribute to decarbonization. Air quality is a key parameter to monitor the environment in terms of health and leisure benefits. In a possible scenario, wearables and recharge stations could supply information about a distributed monitoring system of air quality. The availability of low-power, smart, low-cost, compact embedded systems, such as Arduino Nicla Sense ME, based on BME688 by Bosch, Reutlingen, Germany, and powered by suitable software tools, can provide the hardware to be easily integrated into wearables as well as in solar-powered EVSE (Electric Vehicle Supply Equipment) for scooters and e-bikes. In this way, each e-vehicle, bike, or EVSE can contribute to a distributed monitoring network providing real-time information about micro-climate and pollution. This work experimentally investigates the capability of the BME688 environmental sensor to provide useful and detailed information about air quality. Initial experimental results from measurements in non-controlled and controlled environments show that BME688 is suited to detect the human-perceived air quality. CO2 readout can also be significant for other gas (e.g., CO), while IAQ (Index for Air Quality, from 0 to 500) is heavily affected by relative humidity, and its significance below 250 is quite low for an outdoor uncontrolled environment. Full article
(This article belongs to the Section Physical Sensors)
17 pages, 1354 KiB  
Article
Constrained Symmetric Non-Negative Matrix Factorization with Deep Autoencoders for Community Detection
by Wei Zhang, Shanshan Yu, Ling Wang, Wei Guo and Man-Fai Leung
Mathematics 2024, 12(10), 1554; https://doi.org/10.3390/math12101554 (registering DOI) - 16 May 2024
Abstract
Recently, community detection has emerged as a prominent research area in the analysis of complex network structures. Community detection models based on non-negative matrix factorization (NMF) are shallow and fail to fully discover the internal structure of complex networks. Thus, this article introduces [...] Read more.
Recently, community detection has emerged as a prominent research area in the analysis of complex network structures. Community detection models based on non-negative matrix factorization (NMF) are shallow and fail to fully discover the internal structure of complex networks. Thus, this article introduces a novel constrained symmetric non-negative matrix factorization with deep autoencoders (CSDNMF) as a solution to this issue. The model possesses the following advantages: (1) By integrating a deep autoencoder to discern the latent attributes bridging the original network and community assignments, it adeptly captures hierarchical information. (2) Introducing a graph regularizer facilitates a thorough comprehension of the community structure inherent within the target network. (3) By integrating a symmetry regularizer, the model’s capacity to learn undirected networks is augmented, thereby facilitating the precise detection of symmetry within the target network. The proposed CSDNMF model exhibits superior performance in community detection when compared to state-of-the-art models, as demonstrated by eight experimental results conducted on real-world networks. Full article
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15 pages, 2768 KiB  
Article
Assessment of the Effect on Periodontitis of Antibiotic Therapy and Bacterial Lysate Treatment
by Diana Larisa Ancuţa, Diana Mihaela Alexandru, Florin Muselin, Romeo Teodor Cristina and Cristin Coman
Int. J. Mol. Sci. 2024, 25(10), 5432; https://doi.org/10.3390/ijms25105432 (registering DOI) - 16 May 2024
Abstract
Periodontitis is an inflammatory process that starts with soft tissue inflammation caused by the intervention of oral bacteria. By modulating local immunity, it is possible to supplement or replace current therapeutic methods. The aim of this study was to compare the effects of [...] Read more.
Periodontitis is an inflammatory process that starts with soft tissue inflammation caused by the intervention of oral bacteria. By modulating local immunity, it is possible to supplement or replace current therapeutic methods. The aim of this study was to compare the effects of an immunostimulatory treatment with the antibiotherapy usually applied to periodontitis patients. On a model of periodontitis induced in 30 rats (divided into three equal groups) with bacterial strains selected from the human oral microbiome (Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum and Streptococcus oralis), we administered antibiotics, bacterial lysates and saline for 10 days. Clinically, no significant lesions were observed between the groups, but hematologically, we detected a decrease in lymphocyte and neutrophil counts in both the antibiotic and lysate-treated groups. Immunologically, IL-6 remained elevated compared to the saline group, denoting the body’s effort to compensate for bone loss due to bacterial action. Histopathologically, the results show more pronounced oral tissue regeneration in the antibiotic group and a reduced inflammatory reaction in the lysate group. We can conclude that the proposed bacterial lysate has similar effects to antibiotic therapy and can be considered an option in treating periodontitis, thus eliminating the unnecessary use of antibiotics. Full article
(This article belongs to the Special Issue Periodontitis: Advances in Mechanisms, Treatment and Prevention)
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22 pages, 819 KiB  
Article
Short-to-Medium-Term Wind Power Forecasting through Enhanced Transformer and Improved EMD Integration
by Jiafei Huan, Li Deng, Yue Zhu, Shangguang Jiang and Fei Qi
Energies 2024, 17(10), 2395; https://doi.org/10.3390/en17102395 (registering DOI) - 16 May 2024
Abstract
Accurate wind power forecasting (WPF) is critical in optimizing grid operations and efficiently managing wind energy resources. Challenges arise from the inherent volatility and non-stationarity of wind data, particularly in short-to-medium-term WPF, which extends to longer forecast horizons. To address these challenges, this [...] Read more.
Accurate wind power forecasting (WPF) is critical in optimizing grid operations and efficiently managing wind energy resources. Challenges arise from the inherent volatility and non-stationarity of wind data, particularly in short-to-medium-term WPF, which extends to longer forecast horizons. To address these challenges, this study introduces a novel model that integrates Improved Empirical Mode Decomposition (IEMD) with an enhanced Transformer called TransIEMD. TransIEMD begins by decomposing the wind speed into Intrinsic Mode Functions (IMFs) using IEMD, transforming the scalar wind speed into a vector form that enriches the input data to reveal hidden temporal dynamics. Each IMF is then processed with channel attention, embedding, and positional encoding to prepare inputs for an enhanced Transformer. The Direct Embedding Module (DEM) provides an alternative viewpoint on the input data. The distinctive perspectives of IEMD and DEM offer interaction through cross-attention within the encoder, significantly enhancing the ability to capture dynamic wind patterns. By combining cross-attention and self-attention within the encoder–decoder structure, TransIEMD demonstrates enhanced proficiency in detecting and leveraging long-range dependencies and dynamic wind patterns, improving the forecasting precision. Extensive evaluations on a publicly available dataset from the National Renewable Energy Laboratory (NREL) demonstrate that TransIEMD significantly improves the forecasting accuracy across multiple horizons of 4, 8, 16, and 24 h. Specifically, at the 24 h forecast horizon, TransIEMD achieves reductions in the normalized mean absolute error and root mean square error of 4.24% and 4.37%, respectively, compared to the traditional Transformer. These results confirm the efficacy of integrating IEMD with attention mechanisms to enhance the accuracy of WPF. Full article
(This article belongs to the Section A3: Wind, Wave and Tidal Energy)
24 pages, 3730 KiB  
Article
The Development of a New Vagus Nerve Simulation Electroceutical to Improve the Signal Attenuation in a Living Implant Environment
by Daeil Jo, Hyunung Lee, Youlim Jang, Paul Oh and Yongjin Kwon
Sensors 2024, 24(10), 3172; https://doi.org/10.3390/s24103172 (registering DOI) - 16 May 2024
Abstract
An electroceutical is a medical device that uses electrical signals to control biological functions. It can be inserted into the human body as an implant and has several crucial advantages over conventional medicines for certain diseases. This research develops a new vagus nerve [...] Read more.
An electroceutical is a medical device that uses electrical signals to control biological functions. It can be inserted into the human body as an implant and has several crucial advantages over conventional medicines for certain diseases. This research develops a new vagus nerve simulation (VNS) electroceutical through an innovative approach to overcome the communication limitations of existing devices. A phased array antenna with a better communication performance was developed and applied to the electroceutical prototype. In order to effectively respond to changes in communication signals, we developed the steering algorithm and firmware, and designed the smart communication protocol that operates at a low power that is safe for the patients. This protocol is intended to improve a communication sensitivity related to the transmission and reception distance. Based on this technical approach, the heightened effectiveness and safety of the prototype have been ascertained, with the actual clinical tests using live animals. We confirmed the signal attenuation performance to be excellent, and a smooth communication was achieved even at a distance of 7 m. The prototype showed a much wider communication range than any other existing products. Through this, it is conceivable that various problems due to space constraints can be resolved, hence presenting many benefits to the patients whose last resort to the disease is the VNS electroceutical. Full article
(This article belongs to the Special Issue Body Sensor Networks and Wearables for Health Monitoring)
35 pages, 6597 KiB  
Article
Stealth Aircraft Penetration Trajectory Planning in 3D Complex Dynamic Based on Radar Valley Radius and Turning Maneuver
by Xiaoqiang Lu, Jun Huang, Jingxin Guan and Lei Song
Aerospace 2024, 11(5), 402; https://doi.org/10.3390/aerospace11050402 (registering DOI) - 16 May 2024
Abstract
Based on the quasi-six-degree-of-freedom flight dynamic equations, considering the changes in the elevation angle caused by an increase in the rolling angle during maneuvering turns, which leads to a rise in the radar cross-section. A computational model for the radar detection probability of [...] Read more.
Based on the quasi-six-degree-of-freedom flight dynamic equations, considering the changes in the elevation angle caused by an increase in the rolling angle during maneuvering turns, which leads to a rise in the radar cross-section. A computational model for the radar detection probability of aircraft in complex environments was constructed. By comprehensively considering flight parameters such as turning angle, rolling angle, Mach number, and radar power factor, this study quantitatively analyzed the influence of these factors on the radar detection probability. It revealed the variation patterns of radar detection probability under different flight conditions. The results provide theoretical support for the Radar Valley Radius and Turning Maneuver Method (RVR-TM) based on decision trees, and lay the foundation for the development of subsequent intelligent decision-making models. To further optimize the trajectory selection of aircraft in complex environments, this study combines theoretical analysis with reinforcement learning algorithms to establish an intelligent decision-making model. This model is trained using the Proximal Policy Optimization (PPO) algorithm, and through precisely defining the state space and reward functions, it accomplishes intelligent trajectory planning for stealth aircraft under radar threat scenarios. Full article
(This article belongs to the Special Issue Advanced Aircraft Technology)
30 pages, 5535 KiB  
Review
Potential of 3D Printing for Heat Exchanger Heat Transfer Optimization—Sustainability Perspective
by Beata Anwajler
Inventions 2024, 9(3), 60; https://doi.org/10.3390/inventions9030060 (registering DOI) - 16 May 2024
Abstract
In just a few short years, the additive manufacturing (AM) technology known as 3D printing has experienced intense growth from a niche technology to a disruptive innovation that has captured the imagination of mainstream manufacturers and hobbyists alike. The purpose of this article [...] Read more.
In just a few short years, the additive manufacturing (AM) technology known as 3D printing has experienced intense growth from a niche technology to a disruptive innovation that has captured the imagination of mainstream manufacturers and hobbyists alike. The purpose of this article is to introduce the use of 3D printing for specific applications, materials, and manufacturing processes that help to optimize heat transfer in heat exchangers, with an emphasis on sustainability. The ability to create complex geometries, customize designs, and use advanced materials provides opportunities for more efficient and stable heat transfer solutions. One of the key benefits of incremental technology is the potential reduction in material waste compared to traditional manufacturing methods. By optimizing the design and structure of heat transfer components, 3D printing enables lighter yet more efficient solutions and systems. The localized manufacturing of components, which reduces the need for intensive transportation and associated carbon emissions, can lead to reduced energy consumption and improved overall efficiency. The customization and flexibility of 3D printing enables the integration of heat transfer components into renewable energy systems. This article presents the key challenges to be addressed and the fundamental research needed to realize the full potential of incremental manufacturing technologies to optimize heat transfer in heat exchangers. It also presents a critical discussion and outlook for solving global energy challenges through innovative incremental manufacturing technologies in the heat exchanger sector. Full article
(This article belongs to the Special Issue Innovations in Heat Exchangers)
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25 pages, 6445 KiB  
Article
Impacts of Climate Change and Adaptation Strategies for Rainfed Barley Production in the Almería Province, Spain
by Francesco Saretto, Bishwajit Roy, Ricardo Encarnação Coelho, Alfredo Reder, Giusy Fedele, Robert Oakes, Luigia Brandimarte and Tiago Capela Lourenço
Atmosphere 2024, 15(5), 606; https://doi.org/10.3390/atmos15050606 (registering DOI) - 16 May 2024
Abstract
Mediterranean water-stressed areas face significant challenges from higher temperatures and increasingly severe droughts. We assess the effect of climate change on rainfed barley production in the aridity-prone province of Almería, Spain, using the FAO AquaCrop model. We focus on rainfed barley growth by [...] Read more.
Mediterranean water-stressed areas face significant challenges from higher temperatures and increasingly severe droughts. We assess the effect of climate change on rainfed barley production in the aridity-prone province of Almería, Spain, using the FAO AquaCrop model. We focus on rainfed barley growth by the mid-century (2041–2070) and end-century (2071–2100) time periods, using three Shared Socio-economic Pathway (SSP)-based scenarios: SSP1-2.6, SSP2-4.5, and SSP5-8.5. Using the paired t-test, Spearman and Pearson correlation coefficient, Root Mean Squared Error, and relative Root Mean Squared Error, we verified AquaCrop’s ability to capture local multi-year trends (9 or more years) using standard barley crop parameters, without local recalibration. Starting with a reference Initial Soil Water Content (ISWC), different soil water contents within barley rooting depth were modelled to account for decreases in soil water availability. We then evaluated the efficiency of different climate adaptation strategies: irrigation, mulching, and changing sowing dates. We show average yield changes of +14% to −44.8% (mid-century) and +12% to −55.1% (end-century), with ISWC being the main factor determining yields. Irrigation increases yields by 21.1%, utilizing just 3% of Almería’s superficial water resources. Mulches improve irrigated yield performances by 6.9% while reducing irrigation needs by 40%. Changing sowing dates does not consistently improve yields. We demonstrate that regardless of the scenario used, climate adaptation of field barley production in Almería should prioritize limiting soil water loss by combining irrigation with mulching. This would enable farmers in Almería’s northern communities to maintain their livelihoods, reducing the province’s reliance on horticulture while continuing to contribute to food security goals. Full article
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18 pages, 10683 KiB  
Article
Machine Learning Methods and Visual Observations to Categorize Behavior of Grazing Cattle Using Accelerometer Signals
by Ira Lloyd Parsons, Brandi B. Karisch, Amanda E. Stone, Stephen L. Webb, Durham A. Norman and Garrett M. Street
Sensors 2024, 24(10), 3171; https://doi.org/10.3390/s24103171 (registering DOI) - 16 May 2024
Abstract
Accelerometers worn by animals produce distinct behavioral signatures, which can be classified accurately using machine learning methods such as random forest decision trees. The objective of this study was to identify accelerometer signal separation among parsimonious behaviors. We achieved this objective by (1) [...] Read more.
Accelerometers worn by animals produce distinct behavioral signatures, which can be classified accurately using machine learning methods such as random forest decision trees. The objective of this study was to identify accelerometer signal separation among parsimonious behaviors. We achieved this objective by (1) describing functional differences in accelerometer signals among discrete behaviors, (2) identifying the optimal window size for signal pre-processing, and (3) demonstrating the number of observations required to achieve the desired level of model accuracy,. Crossbred steers (Bos taurus indicus; n = 10) were fitted with GPS collars containing a video camera and tri-axial accelerometers (read-rate = 40 Hz). Distinct behaviors from accelerometer signals, particularly for grazing, were apparent because of the head-down posture. Increasing the smoothing window size to 10 s improved classification accuracy (p < 0.05), but reducing the number of observations below 50% resulted in a decrease in accuracy for all behaviors (p < 0.05). In-pasture observation increased accuracy and precision (0.05 and 0.08 percent, respectively) compared with animal-borne collar video observations. Full article
(This article belongs to the Special Issue Crop and Animal Sensors for Agriculture 5.0)
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8 pages, 1920 KiB  
Article
Characterization of Japanese Encephalitis Virus Isolated from Persistently Infected Mouse Embryo Cells
by Yume Kondo and Tomoyoshi Komiya
Trop. Med. Infect. Dis. 2024, 9(5), 117; https://doi.org/10.3390/tropicalmed9050117 (registering DOI) - 16 May 2024
Abstract
Japanese encephalitis virus (JEV) has a positive-sense single-stranded RNA genome and belongs to the genus Flavivirus of the family Flaviviridae. Persistent JEV infection was previously shown in pig blood cells, which act as a natural reservoir of this virus. We aimed to [...] Read more.
Japanese encephalitis virus (JEV) has a positive-sense single-stranded RNA genome and belongs to the genus Flavivirus of the family Flaviviridae. Persistent JEV infection was previously shown in pig blood cells, which act as a natural reservoir of this virus. We aimed to determine the pathogenicity factors involved in persistent JEV infection by analyzing the pathogenicity and genome sequences of a virus isolated from a persistent infection model. We established persistent JEV infections in cells by inoculating mouse fetus primary cell cultures with the Beijing-1 strain of JEV and then performing repeated infected cell passages, harvesting viruses after each passage while monitoring the plaque size over 100 generations. The virus growth rate was compared among Vero, C6/36, and Neuro-2a cells. The pathogenicity was examined in female ICR mice at several ages. Additionally, we determined the whole-genome sequences. The 134th Beijing-1-derived persistent virus (ME134) grew in Vero cells at a similar rate to the parent strain but did not grow well in C6/36 or Neuro-2a cells. No differences were observed in pathogenicity after intracerebral inoculation in mice of different ages, but the survival time was extended in older mice. Mutations in the persistent virus genomes were found across all regions but were mainly focused in the NS3, NS4b, and 3′NCR regions, with a 34-base-pair deletion found in the variable region. The short deletion in the 3′NCR region appeared to be responsible for the reduced pathogenicity and growth efficiency. Full article
(This article belongs to the Special Issue Japanese Encephalitis)
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18 pages, 2027 KiB  
Article
Runtime Verification-Based Safe MARL for Optimized Safety Policy Generation for Multi-Robot Systems
by Yang Liu and Jiankun Li
Big Data Cogn. Comput. 2024, 8(5), 49; https://doi.org/10.3390/bdcc8050049 (registering DOI) - 16 May 2024
Abstract
The intelligent warehouse is a modern logistics management system that uses technologies like the Internet of Things, robots, and artificial intelligence to realize automated management and optimize warehousing operations. The multi-robot system (MRS) is an important carrier for implementing an intelligent warehouse, which [...] Read more.
The intelligent warehouse is a modern logistics management system that uses technologies like the Internet of Things, robots, and artificial intelligence to realize automated management and optimize warehousing operations. The multi-robot system (MRS) is an important carrier for implementing an intelligent warehouse, which completes various tasks in the warehouse through cooperation and coordination between robots. As an extension of reinforcement learning and a kind of swarm intelligence, MARL (multi-agent reinforcement learning) can effectively create the multi-robot systems in intelligent warehouses. However, MARL-based multi-robot systems in intelligent warehouses face serious safety issues, such as collisions, conflicts, and congestion. To deal with these issues, this paper proposes a safe MARL method based on runtime verification, i.e., an optimized safety policy-generation framework, for multi-robot systems in intelligent warehouses. The framework consists of three stages. In the first stage, a runtime model SCMG (safety-constrained Markov Game) is defined for the multi-robot system at runtime in the intelligent warehouse. In the second stage, rPATL (probabilistic alternating-time temporal logic with rewards) is used to express safety properties, and SCMG is cyclically verified and refined through runtime verification (RV) to ensure safety. This stage guarantees the safety of robots’ behaviors before training. In the third stage, the verified SCMG guides SCPO (safety-constrained policy optimization) to obtain an optimized safety policy for robots. Finally, a multi-robot warehouse (RWARE) scenario is used for experimental evaluation. The results show that the policy obtained by our framework is safer than existing frameworks and includes a certain degree of optimization. Full article
(This article belongs to the Special Issue Field Robotics and Artificial Intelligence (AI))
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25 pages, 4212 KiB  
Article
Heat Transfer Models and Measurements of Brushless DC Motors for Small UASs
by Farid Saemi, Annalaine Whitson and Moble Benedict
Aerospace 2024, 11(5), 401; https://doi.org/10.3390/aerospace11050401 (registering DOI) - 16 May 2024
Abstract
Heat transfer affects a motor’s sizing, its performance, and, ultimately, the overall vehicle’s range and endurance. However, the thermal literature does not have early-stage models for outrunner brushless DC (BLDC) motors found in small unmanned aerial systems (UASs). To address this gap, we [...] Read more.
Heat transfer affects a motor’s sizing, its performance, and, ultimately, the overall vehicle’s range and endurance. However, the thermal literature does not have early-stage models for outrunner brushless DC (BLDC) motors found in small unmanned aerial systems (UASs). To address this gap, we have developed a non-dimensional heat transfer model (Nusselt correlation). Parametric experiments of four different-sized BLDC motors under load in Reynolds-matched wind tunnel tests generated data for model correlation. The motors’ aspect ratios (diameter/length) ranged from 0.9 to 1.5. The freestream Reynolds number of the axial flow over the motors ranged from 20,000 to 40,000. The rotational Reynolds number ranged from 10,000 to 20,000. The results showed that aspect ratio had the largest influence on heat transfer, followed by rotational and freestream Reynolds numbers. A steady-state model used the correlation to predict the motor’s ambient temperature differential within 10 K of experimental data. A case study applied the correlation to predict a hypothetical motor’s continuous torque in different environments. The correlation enables conceptual designers to capture thermally-driven trade-offs in early design stages and reduce costly revisions in later stages. Full article
(This article belongs to the Special Issue Aircraft Design (SI-5/2023))
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15 pages, 806 KiB  
Article
Carbon Emission Analysis and Reporting in Urban Emissions: An Analysis of the Greenhouse Gas Inventories and Climate Action Plans in Sarıçam Municipality
by Orkun Davutluoğlu, Abdurrahman Yavuzdeğer, Burak Esenboğa, Özge Demirdelen, Kübra Tümay Ateş and Tuğçe Demirdelen
Sustainability 2024, 16(10), 4184; https://doi.org/10.3390/su16104184 (registering DOI) - 16 May 2024
Abstract
The urban carbon footprint (UCF) is an important tool for assessing an organization’s ecological impacts and in guiding sustainability efforts. This calculation is usually measured in tons of carbon dioxide equivalent (CO2-eq). Calculations provide important data to determine strategies to reduce [...] Read more.
The urban carbon footprint (UCF) is an important tool for assessing an organization’s ecological impacts and in guiding sustainability efforts. This calculation is usually measured in tons of carbon dioxide equivalent (CO2-eq). Calculations provide important data to determine strategies to reduce the carbon footprint and establish sustainability targets. Various standards and protocols guide UCF calculation, and many organizations aim to make these data transparent to their stakeholders and the public. This study aims to calculate the UCF of Sarıçam Municipality (SM) in the Adana Province of Türkiye. This study includes the greenhouse gas emission inventories resulting from all activities of the SM main service building, guest house, construction site service building, Cultural Center service building, and additional service buildings between 1 January 2022 and 31 December 2022. The calculations include generator fuel consumption, electricity consumption, the refrigerant gas leaks and refills resulting from these activities, the fuel consumed in vehicles owned by the company or whose fuel consumption is under company control, emissions originating from personal travel, emissions originating from customers and visitors, emissions originating from business travel, purchases, etc. Emissions from products purchased and emissions from waste transportation are included. The findings show that, in 2022, the total UCF of SM was equal to 10,862.46 tons of CO2-eq. The Paris Agreement aims to reduce the per capita emissions to approximately two tons of CO2-eq by 2030. The carbon footprint per employee within the municipality was calculated at 12.43 tons of CO2-eq, as derived from the analyzed data. The results reveal the importance of implementing sustainable practices and strategies within SM, such as energy efficiency measures, waste reduction, and the adoption of renewable energy sources, to mitigate its carbon footprint. This study plans to provide a basis for SM’s reduction efforts by keeping greenhouse gas emissions under control. Full article
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17 pages, 5769 KiB  
Article
Evaluating the Effects of Metallic Waste on the Structural and Gamma-Ray Shielding Properties of Epoxy Composites
by Sitah Alanazi, Mohammad Hanfi, Mohammad W. Marashdeh, Mamduh J. Aljaafreh and Karem A. Mahmoud
Polymers 2024, 16(10), 1415; https://doi.org/10.3390/polym16101415 (registering DOI) - 16 May 2024
Abstract
The objective of the research is to develop novel materials that are both inexpensive and have a low density, while also being able to endure the transportation of γ-photons with low-to-medium energy levels. The outcome consisted of four epoxy resins that were strengthened [...] Read more.
The objective of the research is to develop novel materials that are both inexpensive and have a low density, while also being able to endure the transportation of γ-photons with low-to-medium energy levels. The outcome consisted of four epoxy resins that were strengthened with different quantities of heavy metallic waste. The density of the formed composites improved from 1.134 ± 0.022 g/cm3 to 1.560 ± 0.0312 g/cm3 when the waste content was raised from 0 to 40 weight percent. The theoretical investigation was determined using Monte Carlo (MCNP) simulation software, and the results of linear attenuation coefficient were justified experimentally in a low and medium energy range of 15–662 keV. The mass attenuation coefficient results in a low gamma energy range (15–122 keV) varied in between 3.175 and 0.159 cm2/g (for E-MW0 composite) and in between 8.212 and 0.164 cm2/g (for E-MW40 composite). The decrease in mass attenuation coefficient was detected in a medium gamma photon energy range (122–662 keV) with 0.123–0.082 cm2/g (for E-MW0 composite) and 0.121–0.080 cm2/g (for E-MW40 composite). The density of the enhanced composites influenced these parameters. As the metallic waste composition increased, the fabricated composites’ half-value thickness decreased. At 15 keV, the half-value thickness decreased from 0.19 to 0.05 cm. At 59 keV, it fell from 2.70 to 1.41 cm. At 122 keV, it fell from 3.90 to 2.72 cm. At 662 keV, it fell from 7.45 to 5.56 cm. This decrease occurred as the heavy metal waste concentration increased from 0 to 40 wt.%. The study indicates that as metallic waste concentrations rise, there is a rise in the effective atomic number and a decline in the buildup factors. Full article
(This article belongs to the Special Issue Resin-Based Polymer Materials and Related Applications: Volume 2)
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26 pages, 2228 KiB  
Article
Pregestational Prediabetes Induces Maternal Hypothalamic–Pituitary–Adrenal (HPA) Axis Dysregulation and Results in Adverse Foetal Outcomes
by Mathuli Ngema, Nombuso D. Xulu, Phikelelani S. Ngubane and Andile Khathi
Int. J. Mol. Sci. 2024, 25(10), 5431; https://doi.org/10.3390/ijms25105431 (registering DOI) - 16 May 2024
Abstract
Maternal type 2 diabetes mellitus (T2DM) has been shown to result in foetal programming of the hypothalamic–pituitary–adrenal (HPA) axis, leading to adverse foetal outcomes. T2DM is preceded by prediabetes and shares similar pathophysiological complications. However, no studies have investigated the effects of maternal [...] Read more.
Maternal type 2 diabetes mellitus (T2DM) has been shown to result in foetal programming of the hypothalamic–pituitary–adrenal (HPA) axis, leading to adverse foetal outcomes. T2DM is preceded by prediabetes and shares similar pathophysiological complications. However, no studies have investigated the effects of maternal prediabetes on foetal HPA axis function and postnatal offspring development. Hence, this study investigated the effects of pregestational prediabetes on maternal HPA axis function and postnatal offspring development. Pre-diabetic (PD) and non-pre-diabetic (NPD) female Sprague Dawley rats were mated with non-prediabetic males. After gestation, male pups born from the PD and NPD groups were collected. Markers of HPA axis function, adrenocorticotropin hormone (ACTH) and corticosterone, were measured in all dams and pups. Glucose tolerance, insulin and gene expressions of mineralocorticoid (MR) and glucocorticoid (GR) receptors were further measured in all pups at birth and their developmental milestones. The results demonstrated increased basal concentrations of ACTH and corticosterone in the dams from the PD group by comparison to NPD. Furthermore, the results show an increase basal ACTH and corticosterone concentrations, disturbed MR and GR gene expression, glucose intolerance and insulin resistance assessed via the Homeostasis Model Assessment (HOMA) indices in the pups born from the PD group compared to NPD group at all developmental milestones. These observations reveal that pregestational prediabetes is associated with maternal dysregulation of the HPA axis, impacting offspring HPA axis development along with impaired glucose handling. Full article
(This article belongs to the Section Molecular Endocrinology and Metabolism)
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15 pages, 1553 KiB  
Article
Ticks and Tick-Borne Pathogens Circulating in Peri-Domestic Areas in Mainland Portugal
by Leonardo Moerbeck, Ricardo Parreira, Magdalena Szczotko, Gonçalo Seixas, Rita Velez, Małgorzata Dmitryjuk, Ana Sofia Santos, Ana Domingos and Sandra Antunes
Microorganisms 2024, 12(5), 1006; https://doi.org/10.3390/microorganisms12051006 (registering DOI) - 16 May 2024
Abstract
Over the years, tick-borne pathogens (TBPs) have garnered significant interest due to their medical, veterinary and economic importance. Additionally, TBPs have drawn attention to how these microorganisms interact with their own vectors, increasing the risk to human and animal infection of emerging and [...] Read more.
Over the years, tick-borne pathogens (TBPs) have garnered significant interest due to their medical, veterinary and economic importance. Additionally, TBPs have drawn attention to how these microorganisms interact with their own vectors, increasing the risk to human and animal infection of emerging and reemerging zoonoses. In this sense, ticks, which are obligate hematophagous ectoparasites, have a key role in maintaining and transmitting TBPs among humans and animals. The aim of this study was to assess the prevalence of neglected TBPs in mainland Portugal, namely Anaplasma spp., Babesia spp., Ehrlichia spp. and Neoehrlichia mikurensis. DNA fragments were detected in questing ticks collected from five different ecological areas under investigation. To the best of the authors’ knowledge, this study reports new worldwide findings, including B. bigemina infecting Ixodes frontalis, Ixodes ricinus and Rhipicephalus sanguineus sensu lato. Additionally, it presents new findings in Portugal of N. mikurensis infecting I. ricinus and of presumably Wolbachia endosymbionts being detected in I. ricinus. Overall, there were 208 tick samples that were negative for all screened TBPs. The results herein obtained raise concerns about the circulation of neglected TBPs in mainland Portugal, especially in anthropophilic ticks, highlighting the importance of adopting a One Health perspective. Full article
(This article belongs to the Special Issue The One Health Challenge: Zoonotic Parasites)
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17 pages, 5439 KiB  
Article
Pavement Crack Detection Based on the Improved Swin-Unet Model
by Song Chen, Zhixuan Feng, Guangqing Xiao, Xilong Chen, Chuxiang Gao, Mingming Zhao and Huayang Yu
Buildings 2024, 14(5), 1442; https://doi.org/10.3390/buildings14051442 (registering DOI) - 16 May 2024
Abstract
Accurate pavement surface crack detection is crucial for analyzing pavement survey data and the development of maintenance strategies. On the basis of Swin-Unet, this study develops the improved Swin-Unet (iSwin-Unet) model with the developed skip attention module and the residual Swin Transformer block. [...] Read more.
Accurate pavement surface crack detection is crucial for analyzing pavement survey data and the development of maintenance strategies. On the basis of Swin-Unet, this study develops the improved Swin-Unet (iSwin-Unet) model with the developed skip attention module and the residual Swin Transformer block. Based on the channel attention mechanism, the pavement crack region can be better captured while the crack feature channels can be assigned more weights. Taking advantage of the developed residual Swin Transformer block, the encoder architecture can globally model the pavement crack feature. Meanwhile, the crack feature information can be efficiently exchanged. To verify the pavement crack detection performance of the proposed model, we compare the training performance and visualization results with the other three models, which are Swin-Unet, Swin Transformer, and Unet, respectively. Three public benchmarks (CFD, Crack500, and CrackSC) have been adopted for the purpose of training, validation, and testing. Based on the test results, it can be found that the developed iSwin-Unet achieves a significant increase in mF1 score, mPrecision, and mRecall compared to the existing models, thereby establishing its efficacy in pavement crack detection and underlining its significant advancements over current methodologies. Full article
(This article belongs to the Section Building Materials, and Repair & Renovation)
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18 pages, 6181 KiB  
Article
MR Imaging of Adverse Effects and Ocular Growth Decline after Selective Intra-Arterial Chemotherapy for Retinoblastoma
by Christiaan M. de Bloeme, Sabien van Elst, Paolo Galluzzi, Robin W. Jansen, Joeka de Haan, Sophia Göricke, Annette C. Moll, Joseph C. J. Bot, Francis L. Munier, Maja Beck-Popovic, Francesco Puccinelli, Isabelle Aerts, Theodora Hadjistilianou, Selma Sirin, Mériam Koob, Hervé J. Brisse, Liesbeth Cardoen, Philippe Maeder, Marcus C. de Jong and Pim de Graaf
Cancers 2024, 16(10), 1899; https://doi.org/10.3390/cancers16101899 (registering DOI) - 16 May 2024
Abstract
This retrospective multicenter study examines therapy-induced orbital and ocular MRI findings in retinoblastoma patients following selective intra-arterial chemotherapy (SIAC) and quantifies the impact of SIAC on ocular and optic nerve growth. Patients were selected based on medical chart review, with inclusion criteria requiring [...] Read more.
This retrospective multicenter study examines therapy-induced orbital and ocular MRI findings in retinoblastoma patients following selective intra-arterial chemotherapy (SIAC) and quantifies the impact of SIAC on ocular and optic nerve growth. Patients were selected based on medical chart review, with inclusion criteria requiring the availability of posttreatment MR imaging encompassing T2-weighted and T1-weighted images (pre- and post-intravenous gadolinium administration). Qualitative features and quantitative measurements were independently scored by experienced radiologists, with deep learning segmentation aiding total eye volume assessment. Eyes were categorized into three groups: eyes receiving SIAC (Rb-SIAC), eyes treated with other eye-saving methods (Rb-control), and healthy eyes. The most prevalent adverse effects post-SIAC were inflammatory and vascular features, with therapy-induced contrast enhancement observed in the intraorbital optic nerve segment in 6% of patients. Quantitative analysis revealed significant growth arrest in Rb-SIAC eyes, particularly when treatment commenced ≤ 12 months of age. Optic nerve atrophy was a significant complication in Rb-SIAC eyes. In conclusion, this study highlights the vascular and inflammatory adverse effects observed post-SIAC in retinoblastoma patients and demonstrates a negative impact on eye and optic nerve growth, particularly in children treated ≤ 12 months of age, providing crucial insights for clinical management and future research. Full article
(This article belongs to the Special Issue Current Progress and Research Trends in Ocular Oncology)
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14 pages, 5339 KiB  
Article
Dormancy-like Phenotype of Aggregatibacter actinomycetemcomitans: Survival during Famine
by Natalia O. Tjokro, Carolyn B. Marks, Ashley Wu and Casey Chen
Pathogens 2024, 13(5), 418; https://doi.org/10.3390/pathogens13050418 (registering DOI) - 16 May 2024
Abstract
Microbes frequently experience nutrient deprivations in the natural environment and may enter dormancy. Aggregatibacter actinomycetemcomitans is known to establish long-term infections in humans. This study examined the dormancy-like phenotype of an A. actinomycetemcomitans strain D7S-1 and its isogenic smooth-colony mutant D7SS. A tissue [...] Read more.
Microbes frequently experience nutrient deprivations in the natural environment and may enter dormancy. Aggregatibacter actinomycetemcomitans is known to establish long-term infections in humans. This study examined the dormancy-like phenotype of an A. actinomycetemcomitans strain D7S-1 and its isogenic smooth-colony mutant D7SS. A tissue culture medium RPMI-1640 was nutrient-deficient (ND) and unable to support A. actinomycetemcomitans growth. RPMI-1640 amended with bases was nutrient-limited (NL) and supported limited growth of A. actinomycetemcomitans less than the nutrient-enriched (NE) laboratory medium did. Strain D7S-1, after an initial 2-log reduction in viability, maintained viability from day 4 to day 15 in the NL medium. Strain D7SS, after 1-log reduction in viability, maintained viability from day 3 to day 5. In contrast, bacteria in the NE medium were either non-recoverable (D7S-1; >6-log reduction) or continued to lose viability (D7SS; 3-log reduction) on day 5 and beyond. Scanning and transmission electron microscopy showed that A. actinomycetemcomitans in the NL medium formed robust biofilms similar to those in the NE medium but with evidence of stress. A. actinomycetemcomitans in the ND medium revealed scant biofilms and extensive cellular damage. We concluded that A. actinomycetemcomitans grown in the NL medium exhibited a dormancy-like phenotype characterized by minimum growth, prolonged viability, and distinct cellular morphology. Full article
(This article belongs to the Special Issue Aggregatibacter actinomycetemcomitans)
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13 pages, 4339 KiB  
Article
Evaluating the Margins of Breast Cancer Tumors by Using Digital Breast Tomosynthesis with Deep Learning: A Preliminary Assessment
by Wei-Chung Shia, Yu-Hsun Kuo, Fang-Rong Hsu, Joseph Lin, Wen-Pei Wu, Hwa-Koon Wu, Wei-Cheng Yeh and Dar-Ren Chen
Diagnostics 2024, 14(10), 1032; https://doi.org/10.3390/diagnostics14101032 (registering DOI) - 16 May 2024
Abstract
Background: The assessment information of tumor margins is extremely important for the success of the breast cancer surgery and whether the patient undergoes a second operation. However, conducting surgical margin assessments is a time-consuming task that requires pathology-related skills and equipment, and often [...] Read more.
Background: The assessment information of tumor margins is extremely important for the success of the breast cancer surgery and whether the patient undergoes a second operation. However, conducting surgical margin assessments is a time-consuming task that requires pathology-related skills and equipment, and often cannot be provided in a timely manner. To address this challenge, digital breast tomosynthesis technology was utilized to generate detailed cross-sectional images of the breast tissue and integrate deep learning algorithms for image segmentation, achieving an assessment of tumor margins during surgery. Methods: this study utilized post-operative tissue samples from 46 patients who underwent breast-conserving treatment, and generated image sets using digital breast tomosynthesis for the training and evaluation of deep learning models. Results: Deep learning algorithms effectively identifying the tumor area. They achieved a Mean Intersection over Union (MIoU) of 0.91, global accuracy of 99%, weighted IoU of 44%, precision of 98%, recall of 83%, F1 score of 89%, and dice coefficient of 93% on the training dataset; for the testing dataset, MIoU was at 83%, global accuracy at 97%, weighted IoU at 38%, precision at 87%, recall rate at 69%, F1 score at 76%, dice coefficient at 86%. Conclusions: The initial evaluation suggests that the deep learning-based image segmentation method is highly accurate in measuring breast tumor margins. This helps provide information related to tumor margins during surgery, and by using different datasets, this research method can also be applied to the surgical margin assessment of various types of tumors. Full article
(This article belongs to the Special Issue Advances in Breast Radiology)
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14 pages, 2706 KiB  
Article
Methodology for Selecting a Location for a Photovoltaic Farm on the Example of Poland
by Katarzyna Stala-Szlugaj, Piotr Olczak, Jaroslaw Kulpa and Maciej Soltysik
Energies 2024, 17(10), 2394; https://doi.org/10.3390/en17102394 (registering DOI) - 16 May 2024
Abstract
As the LCOE for photovoltaics has decreased several times, it is once again gaining popularity. The intensification of the development of PV installations is contributing to the duck curve phenomenon in an increasing number of countries and, consequently, affecting current electricity prices. Decisions [...] Read more.
As the LCOE for photovoltaics has decreased several times, it is once again gaining popularity. The intensification of the development of PV installations is contributing to the duck curve phenomenon in an increasing number of countries and, consequently, affecting current electricity prices. Decisions on new investments in large-scale PV sources are driven by potential economic and environmental effects, and these, in turn, are subject to locational considerations, both as to the country and its region. In calculating the economic impact of locating a 1 MWp PV farm, it was assumed that the electricity generated by the farm would be fed into the national grid, and that the life of the PV farm would be 20 years. Poland was considered as an example country for the placement of a photovoltaic farm. The authors of this paper proposed that the main verification parameter is the availability of connection capacities to feed the produced electricity into the country’s electricity grid. The methodology proposed by the authors for the selection of the location of a PV farm consists of four steps: step (i) identification and selection of the administrative division of a given country; step (ii) verification of available connection capacities; step (iii) (two stages) verification of other factors related to the location of the PV farm (e.g., information on land availability and the distance of the land from the substation), and analysis of productivity at each potential location and electricity prices achieved on the power exchange; step (iv) economic analysis of the investment—analyses of PV farm energy productivity in monetary terms on an annual basis, cost analysis (CAPEX, OPEX) and evaluation of economic efficiency (DPP, NPV, IRR). The greatest impact on the economic efficiency of a PV project is shown by the value of land (as part of CAPEX), which is specific to a given location, and revenues from energy sales, which are pretty similar for all locations. Full article
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28 pages, 1196 KiB  
Article
Turbulence and Rossby Wave Dynamics with Realizable Eddy Damped Markovian Anisotropic Closure
by Jorgen S. Frederiksen and Terence J. O’Kane
Fluids 2024, 9(5), 116; https://doi.org/10.3390/fluids9050116 (registering DOI) - 16 May 2024
Abstract
The theoretical basis for the Eddy Damped Markovian Anisotropic Closure (EDMAC) is formulated for two-dimensional anisotropic turbulence interacting with Rossby waves in the presence of advection by a large-scale mean flow. The EDMAC is as computationally efficient as the Eddy Damped Quasi Normal [...] Read more.
The theoretical basis for the Eddy Damped Markovian Anisotropic Closure (EDMAC) is formulated for two-dimensional anisotropic turbulence interacting with Rossby waves in the presence of advection by a large-scale mean flow. The EDMAC is as computationally efficient as the Eddy Damped Quasi Normal Markovian (EDQNM) closure, but, in contrast, is realizable in the presence of transient waves. The EDMAC is arrived at through systematic simplification of a generalization of the non-Markovian Direct Interaction Approximation (DIA) closure that has its origin in renormalized perturbation theory. Markovian Anisotropic Closures (MACs) are obtained from the DIA by using three variants of the Fluctuation Dissipation Theorem (FDT) with the information in the time history integrals instead carried by Markovian differential equations for two relaxation functions. One of the MACs is simplified to the EDMAC with analytical relaxation functions and high numerical efficiency, like te EDQNM. Sufficient conditions for the EDMAC to be realizable in the presence of Rossby waves are determined. Examples of the numerical integration of the EDMAC compared with the EDQNM are presented for two-dimensional isotropic and anisotropic turbulence, at moderate Reynolds numbers, possibly interacting with Rossby waves and large-scale mean flow. The generalization of the EDMAC for the statistical dynamics of other physical systems to higher dimension and higher order nonlinearity is considered. Full article
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17 pages, 5091 KiB  
Article
Effects of Graphene Oxide on Endophytic Bacteria Population Characteristics in Plants from Soils Contaminated by Polycyclic Aromatic Hydrocarbons
by Xingxing Zhou, Bo Zhang, Qingzhu Meng and Lingmei Li
Molecules 2024, 29(10), 2342; https://doi.org/10.3390/molecules29102342 (registering DOI) - 16 May 2024
Abstract
Environmental pollution stands as one of the significant global challenges we face today. Polycyclic aromatic hydrocarbons (PAHs), a class of stubborn organic pollutants, have long been a focal point of bioremediation research. This study aims to explore the impact and mechanisms of graphene [...] Read more.
Environmental pollution stands as one of the significant global challenges we face today. Polycyclic aromatic hydrocarbons (PAHs), a class of stubborn organic pollutants, have long been a focal point of bioremediation research. This study aims to explore the impact and mechanisms of graphene oxide (GO) on the phytoremediation effectiveness of PAHs. The results underscore the significant efficacy of GO in accelerating the degradation of PAHs. Additionally, the introduction of GO altered the diversity and community structure of endophytic bacteria within the roots, particularly those genera with potential for PAH degradation. Through LEfSe analysis and correlation studies, we identified specific symbiotic bacteria, such as Mycobacterium, Microbacterium, Flavobacterium, Sphingomonas, Devosia, Bacillus, and Streptomyces, which coexist and interact under the influence of GO, synergistically degrading PAHs. These bacteria may serve as key biological markers in the PAH degradation process. These findings provide new theoretical and practical foundations for the application of nanomaterials in plant-based remediation of polluted soils and showcase the immense potential of plant–microbe interactions in environmental restoration. Full article
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