Mesenchymal stem cells (MSCs) have garnered significant interest in the field of regenerative medicine for their ability to potentially treat various diseases, especially neurodegenerative disorders [...] Full article

During the secretory phase of the menstrual cycle, endometrial fibroblast cells begin to change into large epithelial-like cells called decidual cells in a process called decidualization. This differentiation continues more broadly in the endometrium and forms the decidual tissue during early pregnancy. The cells undergoing decidualization as well as the resulting decidual cells, support successful implantation and placentation during early pregnancy. This study was carried out to identify new potentially important long non-coding RNA (lncRNA) genes that may play a role in human endometrial stromal fibroblast cells (hESF) undergoing decidualization in vitro, and several were found. The expression of nine was further characterized. One of these, AC027288.3, showed a dramatic increase in the expression of hESF cells undergoing decidualization. When AC027288.3 expression was targeted, the ability of the cells to undergo decidualization as determined by the expression of decidualization marker protein-coding genes was significantly altered. The most affected markers of decidualization whose expression was significantly reduced were FOXO1, FZD4, and INHBA. Therefore, AC027288.3 may be a major upstream regulator of the WNT-FOXO1 pathway and activin-SMAD3 pathways previously shown as critical for hESF decidualization. Finally, we explored possible regulators of AC027288.3 expression during human ESF decidualization. Expression was regulated by cAMP and progesterone. Our results suggest that AC027288.3 plays a role in hESF decidualization and identifies several other lncRNA genes that may also play a role. Full article

CD133, a cancer stem cell (CSC) marker in tumors, including melanoma, is associated with tumor recurrence, chemoresistance, and metastasis. Patient-derived melanoma cell lines were transduced with a Tet-on vector expressing CD133, generating doxycycline (Dox)-inducible cell lines. Cells were exposed to Dox for 24 h to induce CD133 expression, followed by RNA-seq and bioinformatic analyses, revealing genes and pathways that are significantly up- or downregulated by CD133. The most significantly upregulated gene after CD133 was amphiregulin (AREG), validated by qRT-PCR and immunoblot analyses. Induced CD133 expression significantly increased cell growth, percentage of cells in S-phase, BrdU incorporation into nascent DNA, and PCNA levels, indicating that CD133 stimulates cell proliferation. CD133 induction also activated EGFR and the MAPK pathway. Potential mechanisms highlighting the role(s) of CD133 and AREG in melanoma CSC were further delineated using AREG/EGFR inhibitors or siRNA knockdown of AREG mRNA. Treatment with the EGFR inhibitor gefitinib blocked CD133-induced cell growth increase and MAPK pathway activation. Importantly, siRNA knockdown of AREG reversed the stimulatory effects of CD133 on cell growth, indicating that AREG mediates the effects of CD133 on cell proliferation, thus serving as an attractive target for novel combinatorial therapeutics in melanoma and cancers with overexpression of both CD133 and AREG. Full article

Though crucial for natural bone healing, local calcium ion (Ca²⁺) and phosphate ion (P_i) concentrations can exceed the cytotoxic limit leading to mitochondrial overload, oxidative stress, and cell death. For bone tissue engineering applications, H₂S can be employed as a cytoprotective molecule to enhance mesenchymal stem cell (MSC) tolerance to cytotoxic Ca²⁺/P_i concentrations. Varied concentrations of sodium hydrogen sulfide (NaSH), a fast-releasing H₂S donor, were applied to assess the influence of H₂S on MSC proliferation. The results suggested a toxicity limit of 4 mM for NaSH and that 1 mM of NaSH could improve cell proliferation and differentiation in the presence of cytotoxic levels of Ca²⁺ (32 mM) and/or P_i (16 mM). To controllably deliver H₂S over time, a novel donor molecule (thioglutamic acid—GluSH) was synthesized and evaluated for its H₂S release profile. Excitingly, GluSH successfully maintained cytoprotective level of H₂S over 7 days. Furthermore, MSCs exposed to cytotoxic Ca²⁺/P_i concentrations in the presence of GluSH were able to thrive and differentiate into osteoblasts. These findings suggest that the incorporation of a sustained H₂S donor such as GluSH into CaP-based bone graft substitutes can facilitate considerable cytoprotection, making it an attractive option for complex bone regenerative engineering applications. Full article

The excessive discharge of phosphorus-containing wastewater contributes to eutrophication, posing a serious threat to aquatic ecosystems. Therefore, methods such as electrocoagulation should be utilized to remove phosphorus from wastewater prior to discharging it into a water body. In this study, we aimed to determine the effectiveness of electrocoagulation in treating simulated phosphorus-containing wastewater under different parameters, including anode material (aluminum, iron, and magnesium), electrode distance (ED) (1, 2.5, and 4.5 cm), pH (3, 6, and 9), and current density (CD) (3, 6, and 9 mA/cm²). Additionally, three models of phosphate removal, the pseudo-first-order (PFO), pseudo-second-order (PSO), and Behnajady–Modirshahla–Ghanbery (BMG) models, were used to simulate the relationship between phosphate concentration and time in the electrocoagulation process using the three metals for phosphate removal. The experimental results showed that the aluminum system had the highest removal efficiency (90%) when energized for 20 min under a CD of 3 mA/cm², followed by those of the iron (80%) and magnesium (35%) systems. Furthermore, a life cycle assessment (LCA) showed that the aluminum electrode system had a smaller environmental impact than the iron and magnesium electrode systems. Therefore, the aluminum electrode system is suitable for phosphorus removal from wastewater. Full article

Environmental pollution and energy crises have garnered global attention. The substantial discharge of organic waste into water bodies has led to profound environmental contamination. Photocatalytic fuel cells (PFCs) enabling the simultaneous removal of refractory contaminants and recovery of the chemical energy contained in organic pollutants provides a potential strategy to solve environmental issues and the energy crisis. This review will discuss the fundamentals, working principle, and configuration development of PFCs and photocatalytic microbial fuel cells (PMFCs). We particularly focus on the strategies for improving the wastewater treatment performance of PFCs/PMFCs in terms of coupled advanced oxidation processes, the rational design of high-efficiency electrodes, and the strengthening of the mass transfer process. The significant potential of PFCs/PMFCs in various fields is further discussed in detail. This review is intended to provide some guidance for the better implementation and widespread adoption of PFC wastewater treatment technologies. Full article

Energy production from coal combustion is responsible for nearly 40% of global CO₂ emissions including SO_x and NO_x. This study aims to produce solid biomass fuels from oil-palm residues by torrefaction, having a high heating value (HHV) equivalent to fossil coals. The experiments were designed using Design Expert version 13 software to optimize the conditions affecting the fuel characteristics of the torrefied products. The statistical analysis suggested that the optimal conditions to achieve a high HHV and fixed carbon content while retaining the mass yield of biomass mainly depended on the temperature and torrefying time, while the size played a less important role in affecting the properties. The optimal conditions were observed to be at 283 °C (120 min) for EFBs, 301 °C (111 min) for PF, and 285 °C (120 min) for PKSs. The maximum HHV of 5229, 5969, and 5265 kcal/kg were achieved for the torrefied EFBs, PF, and PKSs, respectively. The energy efficiency of torrefied biomass was increased to 1.25–1.35. Ecoefficiency analysis suggested that torrefaction should be carried out at high temperatures with a short torrefying time. This low-cost bio-circular torrefied biomass showed promising fuel characteristics that could be potentially used as an alternative to coals. Full article

Shrimp fry counting is an important task for biomass estimation in aquaculture. Accurate counting of the number of shrimp fry in tanks can not only assess the production of mature shrimp but also assess the density of shrimp fry in the tanks, which is very helpful for the subsequent growth status, transportation management, and yield assessment. However, traditional manual counting methods are often inefficient and prone to counting errors; a more efficient and accurate method for shrimp fry counting is urgently needed. In this paper, we first collected and labeled the images of shrimp fry in breeding tanks according to the constructed experimental environment and generated corresponding density maps using the Gaussian kernel function. Then, we proposed a multi-scale attention fusion-based shrimp fry counting network called the SFCNet. Experiments showed that our proposed SFCNet model reached the optimal performance in terms of shrimp fry counting compared to CNN-based baseline counting models, with MAEs and RMSEs of 3.96 and 4.682, respectively. This approach was able to effectively calculate the number of shrimp fry and provided a better solution for accurately calculating the number of shrimp fry. Full article

We are living in an era of advanced nanoscience and nanotechnology. Numerous nanomaterials, culminating in nanorobots, have demonstrated ingenious applications in biomedicine, including breast cancer (BC) nano-theranostics. To solve the complicated problem of BC heterogeneity, non-targeted drug distribution, invasive diagnostics or surgery, resistance to classic onco-therapies and real-time monitoring of tumors, nanorobots are designed to perform multiple tasks at a small scale, even at the organelles or molecular level. Over the last few years, most nanorobots have been bioengineered as biomimetic and biocompatible nano(bio)structures, resembling different organisms and cells, such as urchin, spider, octopus, fish, spermatozoon, flagellar bacterium or helicoidal cyanobacterium. In this review, readers will be able to deepen their knowledge of the structure, behavior and role of several types of nanorobots, among other nanomaterials, in BC theranostics. We summarized here the characteristics of many functionalized nanodevices designed to counteract the main neoplastic hallmark features of BC, from sustaining proliferation and evading anti-growth signaling and resisting programmed cell death to inducing angiogenesis, activating invasion and metastasis, preventing genomic instability, avoiding immune destruction and deregulating autophagy. Most of these nanorobots function as targeted and self-propelled smart nano-carriers or nano-drug delivery systems (nano-DDSs), enhancing the efficiency and safety of chemo-, radio- or photodynamic therapy, or the current imagistic techniques used in BC diagnosis. Most of these nanorobots have been tested in vitro, using various BC cell lines, as well as in vivo, mainly based on mice models. We are still waiting for nanorobots that are low-cost, as well as for a wider transition of these favorable effects from laboratory to clinical practice. Full article

Nanofibrous materials generated through electrospinning have gained significant attention in tissue regeneration, particularly in the domain of bone reconstruction. There is high interest in designing a material resembling bone tissue, and many scientists are trying to create materials applicable to bone tissue engineering with piezoelectricity similar to bone. One of the prospective candidates is highly piezoelectric poly(vinylidene fluoride) (PVDF), which was used for fibrous scaffold formation by electrospinning. In this study, we focused on the effect of PVDF molecular weight (180,000 g/mol and 530,000 g/mol) and process parameters, such as the rotational speed of the collector, applied voltage, and solution flow rate on the properties of the final scaffold. Fourier Transform Infrared Spectroscopy allows for determining the effect of molecular weight and processing parameters on the content of the electroactive phases. It can be concluded that the higher molecular weight of the PVDF and higher collector rotational speed increase nanofibers’ diameter, electroactive phase content, and piezoelectric coefficient. Various electrospinning parameters showed changes in electroactive phase content with the maximum at the applied voltage of 22 kV and flow rate of 0.8 mL/h. Moreover, the cytocompatibility of the scaffolds was confirmed in the culture of human adipose-derived stromal cells with known potential for osteogenic differentiation. Based on the results obtained, it can be concluded that PVDF scaffolds may be taken into account as a tool in bone tissue engineering and are worth further investigation. Full article

Understanding the intricate relationships between diseases is critical for both prevention and recovery. However, there is a lack of suitable methodologies for exploring the precedence relationships within multiple censored time-to-event data, resulting in decreased analytical accuracy. This study introduces the Censored Event Precedence Analysis (CEPA), which is a nonparametric Bayesian approach suitable for understanding the precedence relationships in censored multivariate events. CEPA aims to analyze the precedence relationships between events to predict subsequent occurrences effectively. We applied CEPA to neonatal data from the National Health Insurance Service, identifying the precedence relationships among the seven most commonly diagnosed diseases categorized by the International Classification of Diseases. This analysis revealed a typical diagnostic sequence, starting with respiratory diseases, followed by skin, infectious, digestive, ear, eye, and injury-related diseases. Furthermore, simulation studies were conducted to demonstrate CEPA suitability for censored multivariate datasets compared to traditional models. The performance accuracy reached 76% for uniform distribution and 65% for exponential distribution, showing superior performance in all four tested environments. Therefore, the statistical approach based on CEPA enhances our understanding of disease interrelationships beyond competitive methodologies. By identifying disease precedence with CEPA, we can preempt subsequent disease occurrences and propose a healthcare system based on these relationships. Full article

Frailty is increasingly recognized as a significant health concern, particularly due to its association with cardiovascular pathologies. This study aims to examine how vascular endothelial dysfunction, a known premorbid stage in the pathophysiology of cardiovascular diseases, contributes to the link between cardiovascular illness and frailty. Methods: The inclusion criteria allowed us to focus on original clinical research articles published in English between January 2014 and January 2024, which reported quantitative assessments of the relationship between frailty and vascular endothelial dysfunction. Excluded from the study were systematic literature reviews, meta-analyses, editorials, conference articles, theses, methodological articles, and studies using animal or cell culture models. Searches were conducted of electronic databases, including Scopus, ScienceDirect, and Medline, up to 22 January 2024. The risk of bias was assessed using the Joanna Briggs Institute’s critical appraisal tools. The methods used to present and synthesize the results involved data extraction and categorization based on biomolecular and clinical findings of endothelial dysfunction. Results: Following the application of the inclusion and exclusion criteria, a total of 29 studies were identified. Vascular endothelial dysfunction was associated with increased frailty phenotypes, and we also identified SGLT-2 inhibitors’ potential role as an anti-fragility treatment that affects endothelial dysfunction. This study found that the physical and biomolecular markers of endothelial dysfunction are associated with frailty measures and have predictive value for incident frailty. Furthermore, some studies have shown inflammation to have an impact on endothelial dysfunction and frailty, and an innovative age-related chronic inflammation measure has been proven to predict frailty scores. Conclusions: The current evidence suggests an association between endothelial dysfunction and frailty, highlighting the need for further research to elucidate the underlying mechanisms. Full article

Solid–liquid separation plays a decisive role in various industrial applications particularly in the treatment and purification of suspensions. Solid bowl centrifuges, such as the decanter centrifuge, are commonly employed in these processes as they operate continuously and enable high throughputs with short processing times. However, predicting the separation performance of solid bowl centrifuges proves to be challenging due to dynamic phenomena within the apparatus, such as particle settling, sediment build-up, consolidation and sediment transport. In practice, design considerations and the dimensioning of the apparatus rely on analytical models and the manufacturer’s expertise. Computational Fluid Dynamics (CFD) offers a way to deepen our understanding of these devices by allowing detailed examination of flow phenomena and their influence on the separation processes. This study utilizes the open-source software OpenFOAM to simulate multiphase flow in a laboratory-scale decanter centrifuge, solving individual transport equations for each particle size class. The basis is the characterization of the material through targeted laboratory experiments to derive material functions that describe the hindered settling and the sediment consolidation. Furthermore, experiments on a laboratory decanter served as validation. The results demonstrate the solver’s capability to replicate clarification and classification within the apparatus. Furthermore, the solver supports the definition of geometries tailored to specific separation tasks. This research demonstrates the potential of CFD for a better understanding of complex centrifuge processes and for optimizing their design to improve performance. Full article

Wildfires pose a direct threat to the property, life, and well-being of the population of Montana, USA, and indirectly to their health through hazardous smoke and gases emitted into the atmosphere. Studies have shown that elevated levels of particulate matter cause impacts to human health ranging from early death, to neurological and immune diseases, to cancer. Although there is currently a network of ground-based air quality sensors (n = 20) in Montana, the geographically sparse network has large gaps and lacks the ability to make accurate predictions for air quality in many areas of the state. Using the random forest method, a predictive model was developed in the Google Earth Engine (GEE) environment to estimate PM2.5 concentrations using satellite-based aerosol optical depth (AOD), dewpoint temperature (DPT), relative humidity (RH), wind speed (WIND), wind direction (WDIR), pressure (PRES), and planetary-boundary-layer height (PBLH). The validity of the prediction model was evaluated using 10-fold cross validation with a R² value of 0.572 and RMSE of 9.98 µg/m³. The corresponding R² and RMSE values for ‘held-out data’ were 0.487 and 10.53 µg/m³. Using the validated prediction model, daily PM2.5 concentration maps (1 km-resolution) were estimated from 2012 to 2023 for the state of Montana. These concentration maps are accessible via an application developed using GEE. The product provides valuable insights into spatiotemporal trends of PM2.5 concentrations, which will be useful for communities to take appropriate mitigation strategies and minimize hazardous PM2.5 exposure. Full article

A growing number of organizations have used artificial intelligence (AI) to make decisions to replace human resource (HR) workers; yet, the fairness perceptions of the people affected by the decision are still unclear. Given that an organization’s sustainability is significantly influenced by individuals’ perceptions of fairness, this study takes a resume-screening scenario as an example to explore the impact of AI replacing humans on applicants’ perceptions of fairness. This study adopts the method of the online scenario experiment and uses SPSS to analyze the experimental data: 189 and 214 people, respectively, participated in two online scenarios, with two independent variables of decision makers (AI and humans), two dependent variables of procedural and distributive fairness, and two moderating variables of outcome favorability and the expertise of AI. The results show that the applicants tend to view AI screening resumes as less fair than humans. Furthermore, moderating effects exist between the outcome favorability and the expertise of AI. This study reveals the impact of AI substituting for humans in decision-making on fairness. The proposed model can help organizations use AI to screen resumes more effectively. And future research can explore the collaboration between humans and AI to make human resource management decisions. Full article

A new approach for output feedback ${\mathcal{L}}_1$ adaptive control based on a proportional adaptation law is presented. The effectiveness of this design is assessed in simulation and validated through real-time testing on an airfoil pitch control wind tunnel experimental rig. Experimental evaluation of the robustness of the controllers, assessed by introducing various disturbances into the control signals, shows that the adaptive control has a better performance compared to PID control, particularly in scenarios with reduced control effectiveness and time-varying disturbances. The experimental results demonstrate the efficacy of the proposed method in practical applications. Full article

Edible grey oyster mushroom, Pleurotus sajor-caju, β (1,3), (1,6) glucan possesses a wide range of biological activities, including anti-inflammation, anti-microorganism and antioxidant. However, its biological activity is limited by low water solubility resulting from its high molecular weight. Our previous study demonstrated that enzymatic hydrolysis of grey oyster mushroom β-glucan using Hevea β-1,3-glucanase isozymes obtains a lower molecular weight and higher water solubility, Pleurotus sajor-caju glucanoligosaccharide (Ps-GOS). Additionally, Ps-GOS potentially reduces osteoporosis by enhancing osteoblast–bone formation, whereas its effect on osteoclast–bone resorption remains unknown. Therefore, our study investigated the modulatory activities and underlying mechanism of Ps-GOS on Receptor activator of nuclear factor kappa-Β ligand (RANKL) -induced osteoclastogenesis in pre-osteoclastic RAW 264.7 cells. Cell cytotoxicity of Ps-GOS on RAW 264.7 cells was determined by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay and its effect on osteoclast differentiation was determined by tartrate-resistant acid phosphatase (TRAP) staining. Additionally, its effect on osteoclast bone-resorptive ability was detected by pit formation assay. The osteoclastogenic-related factors were assessed by quantitative reverse transcriptase polymerase chain reaction (qRT-PCR), Western blot and immunofluorescence. The results revealed that Ps-GOS was non-toxic and significantly suppressed the formation of mature osteoclast multinucleated cells and their resorption activity by reducing the number of TRAP-positive cells and pit formation areas in a dose-dependent manner. Additionally, Ps-GOS attenuated the nuclear factor kappa light chain-enhancer of activated B cells’ P65 (NFκB-P65) expression and their subsequent master osteoclast modulators, including nuclear factor of activated T cell c1 (NFATc1) and Fos proto-oncogene (cFOS) via the NF-κB pathway. Furthermore, Ps-GOS markedly inhibited RANK expression, which serves as an initial transmitter of many osteoclastogenesis-related cascades and inhibited proteolytic enzymes, including TRAP, matrix metallopeptidase 9 (MMP-9) and cathepsin K (CTK). These findings indicate that Ps-GOS could potentially be beneficial as an effective natural agent for bone metabolic disease. Full article

The assessment of sustainable tourism development in the rural areas of the Aktobe oblast of Kazakhstan involved thoroughly analyzing multiple dimensions. Environmental, socio-economic, and cultural sustainability aspects were considered to comprehensively understand the region’s tourism potential. The study began by evaluating the available tourism resources in rural Aktobe. This included assessing natural attractions such as landscapes, wildlife, and geological features, as well as cultural heritage sites and infrastructure like accommodation facilities and transportation networks. A crucial aspect of the study was to analyze the environmental impact of tourism activities in rural areas. This involved evaluating the effects on ecosystems and natural resources. The measures for conserving these resources were also identified. Another focus was on the socio-cultural aspects of tourism development. The study aimed to preserve local traditions, cultural heritage, and community identity amidst tourism growth. Strategies for achieving socio-cultural sustainability were devised. Ranking methods were employed to identify key factors influencing rural tourism development. These methods helped prioritize areas for improvement and resource allocation. A balanced approach was adopted to assess the interaction between different dimensions of sustainability. This ensured that environmental, economic, and socio-cultural aspects were considered equally to achieve overall sustainable tourism development. ArcGIS 10 was used for data analysis and visualization. Maps and charts were created to represent spatial and statistical information, aiding in identifying trends and patterns. The study findings were crucial for identifying priority areas for infrastructure development and formulating strategies and programs for rural tourism promotion. The study aimed to ensure that tourism development aligns with the principles of sustainable development, benefiting both the local communities and the environment. The study provided valuable insights into the current status of rural tourism in Aktobe oblast and offered recommendations for sustainable development, contributing to the region’s long-term prosperity. Full article

Recognizing the omnipresence of mathematics across various contexts, this paper addresses the untapped potential of museums as rich venues for informal mathematics learning beyond traditional educational settings like classrooms. This paper presents the InformalMath program, designed for the professional development of primary and middle school teachers using integrating mathematics education within art and history museums through designing mathematics visit workshops. Specifically, the focus is placed on Phase 1 of the program, in which teachers participated in two informal mathematics education workshops at two museums in Turin, Italy, and were asked to reflect on their participation through a written essay. The analysis of the essays reveals significant engagement, appreciation of mathematics as a cultural artifact, and the emergence of creativity and inclusion among participating teachers. These findings highlight the benefits of such interdisciplinary approaches in enhancing mathematical understanding and pedagogical strategies. Conclusions emphasize the program’s success in not only enriching teachers’ instructional repertoire but also in promoting a more holistic, engaging, and contextualized approach to mathematics education, suggesting a promising avenue for future educational practices and research in informal learning environments. Full article

Urban plant diversity is one of the key elements for sustainable urban development. Urban plant landscapes not only create a variety of experiences for residents but also have a positive effect on their physiology and psychology. In order to better introduce nature into urban green spaces, this study conducted a field survey in Nanjing, China, to analyze the current situation of spontaneous plants in Nanjing’s urban green spaces and propose a plant planning strategy that takes into account both ecology and residents’ well-being. This study surveyed the herbaceous plant resources in 96 sample plots in nine typical urban parks in Nanjing, and recorded 284 plant species in 192 genera and 78 families. The research results show that the differences in plant diversity, richness, and evenness among urban parks in Nanjing are significant; combined with cluster analysis and ranking results, the total area of urban parks, green space construction time, lighting conditions, and management frequency have an impact on plant communities. Further analysis of the species composition of plant communities showed that moderate management frequency in urban parks can increase plant diversity. With the advantages of both high ecological benefits and low management costs, a model of “artificial plants + native spontaneous plants” was finally proposed for the planting of herbaceous plants in sustainable urban green spaces. Full article

Unmanned aerial vehicle (UAV) air-to-ground (AG) communication plays a critical role in the evolving space–air–ground integrated network of the upcoming sixth-generation cellular network (6G). The integration of massive multiple-input multiple-output (MIMO) systems has become essential for ensuring optimal performing communication technologies. This article presents a novel dual-driven learning-based network for millimeter-wave (mm-wave) massive MIMO symbol detection of UAV AG communications. Our main contribution is that the proposed approach combines a data-driven symbol-correction network with a model-driven orthogonal approximate message passing network (OAMP-Net). Through joint training, the dual-driven network reduces symbol detection errors propagated through each iteration of the model-driven OAMP-Net. The numerical results demonstrate the superiority of the dual-driven detector over the conventional minimum mean square error (MMSE), orthogonal approximate message passing (OAMP), and OAMP-Net detectors at various noise powers and channel estimation errors. The dual-driven MIMO detector exhibits a 2–3 dB lower signal-to-noise ratio (SNR) requirement compared to the MMSE and OAMP-Net detectors to achieve a bit error rate (BER) of $1\times {10}^{-2}$ when the channel estimation error is −30 dB. Moreover, the dual-driven MIMO detector exhibits an increased tolerance to channel estimation errors by 2–3 dB to achieve a BER of $1\times {10}^{-3}$. Full article

Human papillomavirus (HPV) is associated with cellular changes in the cervix leading to cancer, which highlights the importance of vaccination in preventing HPV infections and subsequent cellular changes. Women undergoing the loop electrosurgical excision procedure (LEEP), a treatment for high-grade cervical intraepithelial neoplasia (CIN2+), remain at risk of recurrence. This study assessed the effect of post-conization HPV vaccination on the viral status of women at six months post-conization, aiming to evaluate the vaccine’s effectiveness in preventing recurrence of CIN2+. A retrospective cohort study was conducted among women in Troms and Finnmark who underwent conization in 2022. Using the SymPathy database and the national vaccination register (SYSVAK), we analyzed the vaccination statuses and HPV test results of women born before 1991, who had not received the HPV vaccine prior to conization. Out of 419 women undergoing conization, 243 met the inclusion criteria. A significant association was found between post-conization HPV vaccination and a negative HPV test at six months of follow-up (ARR = 12.1%, p = 0.039). Post-conization HPV vaccination significantly reduced the risk of a positive HPV test at the first follow-up, suggesting its potential in preventing the recurrence of high-grade cellular changes. However, the retrospective design and the insufficient control of confounding variables in this study underscore the need for further studies to confirm these findings. Full article