The 2023 MDPI Annual Report has
been released!
 
17 pages, 9723 KiB  
Article
Study of the Adsorption and Separation Behavior of Scandium and Zirconium by Trialkyl Phosphine Oxide-Modified Resins in Sulfuric and Hydrochloric Acid Media
by Botao Xu, Xiangbiao Yin, Shunyan Ning, Yilai Zhong, Xinpeng Wang, Toyohisa Fujita, Mohammed F. Hamza and Yuezhou Wei
Toxics 2024, 12(5), 350; https://doi.org/10.3390/toxics12050350 (registering DOI) - 10 May 2024
Abstract
Zirconium is recognized as one of the main impurities of the rare earth element scandium during purification. It presents significant challenges due to its similar chemical properties, making separating it difficult. This study used trialkyl phosphine oxide (TRPO) as a functional ligand, and [...] Read more.
Zirconium is recognized as one of the main impurities of the rare earth element scandium during purification. It presents significant challenges due to its similar chemical properties, making separating it difficult. This study used trialkyl phosphine oxide (TRPO) as a functional ligand, and the effects of carrier type and acidity on adsorption performance were first investigated. Among these, the novel extraction resin SiO2-P as a carrier for TRPO demonstrated more prominent separation performance in 0.2 M H2SO4 and 5 M HCl solutions. The kinetic and isotherm data were consistent with the pseudo-secondary kinetics and Langmuir model, respectively, and the adsorption process could be regarded as homogeneous monolayer adsorption subject to the dual effects of chemisorption and internal diffusion. In addition, thermodynamic analysis showed that the adsorption process of zirconium under the experimental conditions was a spontaneous endothermic process. Combined with the results of SEM-EDS, FT-IR, and XPS analyses, scandium and zirconium were successfully adsorbed by the resin and uniformly distributed on its surface, and the greater affinity of the P=O groups on the resin for zirconium was the critical factor contributing to the separation of scandium and zirconium. Finally, scandium and zirconium in sulfuric acid and hydrochloric acid media were extracted and separated by column experiments, and the purity of scandium could reach 99.8% and 99.99%, respectively. Full article
(This article belongs to the Section Toxicity Reduction and Environmental Remediation)
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22 pages, 34378 KiB  
Article
Polarization-Based Reflection Suppression Method and Its Application to Target Detection
by Jin Duan, Jialin Wang, Qiang Fu, Guofang Xie, Suxin Mo and Ruisen Fang
Photonics 2024, 11(5), 445; https://doi.org/10.3390/photonics11050445 (registering DOI) - 10 May 2024
Abstract
Active illumination light becomes strongly reflective interference light after specular reflection. It causes saturation in some areas of the image during target detection, resulting in the inability to recognize detailed target feature information. This greatly limits the application of active illumination detection. Based [...] Read more.
Active illumination light becomes strongly reflective interference light after specular reflection. It causes saturation in some areas of the image during target detection, resulting in the inability to recognize detailed target feature information. This greatly limits the application of active illumination detection. Based on the Mueller matrix analysis of the difference in polarization characteristics between the background specular reflected light and the target reflected light, we propose a reflection suppression method based on orthogonal polarization imaging. The method employs a polarization modulation strategy in a bidirectional manner between the light source and the detector. First, the polarization information difference is amplified by active polarized illumination between the background specular reflected light and the target reflected light. Then, the target recovery is achieved by suppressing the background specular reflected light through the polarized orthogonal imaging method. Meanwhile, this method can also be used for moving target detection. The experimental results show that the reflection suppression method of orthogonal polarization imaging can effectively suppress the interference of specular reflection on the target image. Additionally, it can reduce the problems of missed and false detection that occurs in moving target detection and improve the active illumination detection effect. Full article
(This article belongs to the Section Optical Interaction Science)
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39 pages, 21493 KiB  
Article
Infection-Free and Enhanced Wound Healing Potential of Alginate Gels Incorporating Silver and Tannylated Calcium Peroxide Nanoparticles
by Alexandra Catalina Bîrcă, Oana Gherasim, Adelina-Gabriela Niculescu, Alexandru Mihai Grumezescu, Bogdan Ștefan Vasile, Dan Eduard Mihaiescu, Ionela Andreea Neacșu, Ecaterina Andronescu, Roxana Trușcă, Alina Maria Holban, Ariana Hudiță and George-Alexandru Croitoru
Int. J. Mol. Sci. 2024, 25(10), 5196; https://doi.org/10.3390/ijms25105196 (registering DOI) - 10 May 2024
Abstract
The treatment of chronic wounds involves precise requirements and complex challenges, as the healing process cannot go beyond the inflammatory phase, therefore increasing the healing time and implying a higher risk of opportunistic infection. Following a better understanding of the healing process, oxygen [...] Read more.
The treatment of chronic wounds involves precise requirements and complex challenges, as the healing process cannot go beyond the inflammatory phase, therefore increasing the healing time and implying a higher risk of opportunistic infection. Following a better understanding of the healing process, oxygen supply has been validated as a therapeutic approach to improve and speed up wound healing. Moreover, the local implications of antimicrobial agents (such as silver-based nano-compounds) significantly support the normal healing process, by combating bacterial contamination and colonization. In this study, silver (S) and tannylated calcium peroxide (CaO2@TA) nanoparticles were obtained by adapted microfluidic and precipitation synthesis methods, respectively. After complementary physicochemical evaluation, both types of nanoparticles were loaded in (Alg) alginate-based gels that were further evaluated as possible dressings for wound healing. The obtained composites showed a porous structure and uniform distribution of nanoparticles through the polymeric matrix (evidenced by spectrophotometric analysis and electron microscopy studies), together with a good swelling capacity. The as-proposed gel dressings exhibited a constant and suitable concentration of released oxygen, as shown for up to eight hours (UV–Vis investigation). The biofilm modulation data indicated a synergistic antimicrobial effect between silver and tannylated calcium peroxide nanoparticles, with a prominent inhibitory action against the Gram-positive bacterial biofilm after 48 h. Beneficial effects in the human keratinocytes cultured in contact with the obtained materials were demonstrated by the performed tests, such as MTT, LDH, and NO. Full article
(This article belongs to the Special Issue Nanoparticles in Nanobiotechnology and Nanomedicine)
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23 pages, 15745 KiB  
Article
An Integrated Petrographic, Geomatic and Geophysical Approach for the Characterization of the Carbonate Rocks of the Calcari di Cagliari Formation
by Giuseppe Casula, Silvana Fais, Francesco Cuccuru, Maria Giovanna Bianchi and Paola Ligas
Minerals 2024, 14(5), 501; https://doi.org/10.3390/min14050501 (registering DOI) - 10 May 2024
Abstract
Non-invasive techniques, such as close-range photogrammetry (CRP) and 3D ultrasonic tomography complemented with optical and scanning electron microscopy and mercury porosimetry, were applied to characterize the carbonate rock samples of the Calcari di Cagliari formation. The integrated approach started with the computation of [...] Read more.
Non-invasive techniques, such as close-range photogrammetry (CRP) and 3D ultrasonic tomography complemented with optical and scanning electron microscopy and mercury porosimetry, were applied to characterize the carbonate rock samples of the Calcari di Cagliari formation. The integrated approach started with the computation of high-resolution 3D models of the carbonate samples using the CRP technique to produce 3D high-resolution models texturized both with natural colors and intensity. Starting from the 3D models from previous techniques, a 3D ultrasonic tomography on each rock sample was accurately planned and carried out in order to detect the elastic properties of such rocks and relate them to textural heterogeneity or internal defects. The results indicate that the relationship between longitudinal velocity and rock properties is complex even in the same carbonate formation. Understanding the relationship between the geomatic and geophysical responses in the investigated rock properties, such as textural characteristics and especially structure and geometry of pores, type of pores, tortuosity and cementing material, is important for many practical applications and especially in the diagnostic process of the conservation state of monumental structures. The integration of the above non-invasive techniques complemented by petrographical–petrophysical data proved to be a powerful method to associate each lithotype with a different susceptibility to degradation. The results presented in this paper demonstrate that the proposed integrated use of complementary methodologies would guarantee the reproducibility of the measurements both at the laboratory and field scale for the monitoring in time of the rock condition while giving a useful contribution in making decisions on an appropriate remedial strategy. Full article
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15 pages, 6160 KiB  
Article
miR-423-5p Regulates Skeletal Muscle Growth and Development by Negatively Inhibiting Target Gene SRF
by Yanqin Pang, Jing Liang, Jianfang Huang, Ganqiu Lan, Fumei Chen, Hui Ji and Yunxiang Zhao
Genes 2024, 15(5), 606; https://doi.org/10.3390/genes15050606 (registering DOI) - 10 May 2024
Abstract
The process of muscle growth directly affects the yield and quality of pork food products. Muscle fibers are created during the embryonic stage, grow following birth, and regenerate during adulthood; these are all considered to be phases of muscle development. A multilevel network [...] Read more.
The process of muscle growth directly affects the yield and quality of pork food products. Muscle fibers are created during the embryonic stage, grow following birth, and regenerate during adulthood; these are all considered to be phases of muscle development. A multilevel network of transcriptional, post-transcriptional, and pathway levels controls this process. An integrated toolbox of genetics and genomics as well as the use of genomics techniques has been used in the past to attempt to understand the molecular processes behind skeletal muscle growth and development in pigs under divergent selection processes. A class of endogenous noncoding RNAs have a major regulatory function in myogenesis. But the precise function of miRNA-423-5p in muscle development and the related molecular pathways remain largely unknown. Using target prediction software, initially, the potential target genes of miR-423-5p in the Guangxi Bama miniature pig line were identified using various selection criteria for skeletal muscle growth and development. The serum response factor (SRF) was found to be one of the potential target genes, and the two are negatively correlated, suggesting that there may be targeted interactions. In addition to being strongly expressed in swine skeletal muscle, miR-423-5p was also up-regulated during C2C12 cell development. Furthermore, real-time PCR analysis showed that the overexpression of miR-423-5p significantly reduced the expression of myogenin and the myogenic differentiation antigen (p < 0.05). Moreover, the results of the enzyme-linked immunosorbent assay (ELISA) demonstrated that the overexpression of miR-423-5p led to a significant reduction in SRF expression (p < 0.05). Furthermore, miR-423-5p down-regulated the luciferase activities of report vectors carrying the 3′ UTR of porcine SRF, confirming that SRF is a target gene of miR-423-5p. Taken together, miR-423-5p’s involvement in skeletal muscle differentiation may be through the regulation of SRF. Full article
(This article belongs to the Section Animal Genetics and Genomics)
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13 pages, 1382 KiB  
Article
Fish Emulsions, Cyano-Fertilizer, and Seaweed Extracts Affect Bell Pepper (Capsicum annuum L.) Plant Architecture, Yield, and Fruit Quality
by Allison Wickham and Jessica G. Davis
Horticulturae 2024, 10(5), 491; https://doi.org/10.3390/horticulturae10050491 (registering DOI) - 10 May 2024
Abstract
Bell peppers (Capsicum annuum) were grown in a greenhouse to evaluate organic fertilizer and foliar seaweed application effects on plant architecture, yield, and fruit quality. Many organic fertilizers contain phytohormones intrinsically. Hydrolyzed and non-hydrolyzed fish fertilizer and cyano-fertilizer treatments were applied [...] Read more.
Bell peppers (Capsicum annuum) were grown in a greenhouse to evaluate organic fertilizer and foliar seaweed application effects on plant architecture, yield, and fruit quality. Many organic fertilizers contain phytohormones intrinsically. Hydrolyzed and non-hydrolyzed fish fertilizer and cyano-fertilizer treatments were applied in split applications every 7 days over a 135-day growing period. Control plants received no supplemental N. Each fertilizer treatment received applications of one of two different foliar seaweeds or no foliar seaweed in a 4 × 3 factorial design with three replications. Both hydrolyzed and non-hydrolyzed fish fertilizers and cyano-fertilizer increased the number of branches per plant compared to the N-deficient control. The plants receiving cyano-fertilizer or non-hydrolyzed fish fertilizer yielded more than the N-deficient control, and those treatments received 2–3 times the auxin application as the hydrolyzed fish fertilizer. In addition, the leaves from the plants treated with non-hydrolyzed fish fertilizer contained substantially higher levels of abscisic acid, although no abscisic acid was detected in the fertilizers. Both seaweed products decreased the number of fruits that were “bell”-shaped and increased the number of “long”-shaped fruits. Organic fertilizers are complex matrices of nutrients, phytohormones, and other metabolites, making it very challenging to determine the mechanisms behind the observations. Full article
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27 pages, 384 KiB  
Review
Updates on the Management of Colorectal Cancer in Older Adults
by Conor D. J. O’Donnell, Joleen Hubbard and Zhaohui Jin
Cancers 2024, 16(10), 1820; https://doi.org/10.3390/cancers16101820 (registering DOI) - 10 May 2024
Abstract
Colorectal cancer (CRC) poses a significant global health challenge. Notably, the risk of CRC escalates with age, with the majority of cases occurring in those over the age of 65. Despite recent progress in tailoring treatments for early and advanced CRC, there is [...] Read more.
Colorectal cancer (CRC) poses a significant global health challenge. Notably, the risk of CRC escalates with age, with the majority of cases occurring in those over the age of 65. Despite recent progress in tailoring treatments for early and advanced CRC, there is a lack of prospective data to guide the management of older patients, who are frequently underrepresented in clinical trials. This article reviews the contemporary landscape of managing older individuals with CRC, highlighting recent advancements and persisting challenges. The role of comprehensive geriatric assessment is explored. Opportunities for treatment escalation/de-escalation, with consideration of the older adult’s fitness level. are reviewed in the neoadjuvant, surgical, adjuvant, and metastatic settings of colon and rectal cancers. Immunotherapy is shown to be an effective treatment option in older adults who have CRC with microsatellite instability. Promising new technologies such as circulating tumor DNA and recent phase III trials adding later-line systemic therapy options are discussed. Clinical recommendations based on the data available are summarized. We conclude that deliberate efforts to include older individuals in future colorectal cancer trials are essential to better guide the management of these patients in this rapidly evolving field. Full article
(This article belongs to the Topic Advances in Colorectal Cancer Therapy)
16 pages, 4499 KiB  
Article
The Effect of Methyl-Derivatives of Flavanone on MCP-1, MIP-1β, RANTES, and Eotaxin Release by Activated RAW264.7 Macrophages
by Małgorzata Kłósek, Anna Kurek-Górecka, Radosław Balwierz, Agnieszka Krawczyk-Łebek, Edyta Kostrzewa-Susłow, Joanna Bronikowska, Dagmara Jaworska and Zenon P. Czuba
Molecules 2024, 29(10), 2239; https://doi.org/10.3390/molecules29102239 (registering DOI) - 10 May 2024
Abstract
Chemokines, also known as chemotactic cytokines, stimulate the migration of immune cells. These molecules play a key role in the pathogenesis of inflammation leading to atherosclerosis, neurodegenerative disorders, rheumatoid arthritis, insulin-resistant diabetes, and cancer. Moreover, they take part in inflammatory bowel disease (IBD). [...] Read more.
Chemokines, also known as chemotactic cytokines, stimulate the migration of immune cells. These molecules play a key role in the pathogenesis of inflammation leading to atherosclerosis, neurodegenerative disorders, rheumatoid arthritis, insulin-resistant diabetes, and cancer. Moreover, they take part in inflammatory bowel disease (IBD). The main objective of our research was to determine the activity of methyl-derivatives of flavanone, namely, 2′-methylflavanone (5B), 3′-methylflavanone (6B), 4′-methylflavanone (7B), and 6-methylflavanone (8B), on the releasing of selected cytokines by RAW264.7 macrophages activated by LPS. We determined the concentration of chemokines belonging to the CC chemokine family, namely, MCP-1, MIP-1β, RANTES, and eotaxin, using the Bio-Plex Magnetic Luminex Assay and the Bio-PlexTM 200 System. Among the tested compounds, only 5B and 6B had the strongest effect on inhibiting the examined chemokines’ release by macrophages. Therefore, 5B and 6B appear to be potentially useful in the prevention of diseases associated with the inflammatory process. Full article
(This article belongs to the Special Issue Recent Research in Plant Polyphenols and Gut Health)
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17 pages, 3676 KiB  
Article
Coordination Compounds of Nickel(II) with 3,5–Dibromo–Salicylaldehyde: Structure and Interaction with Biomolecules
by Georgios I. Psarras, Ariadni Zianna, Antonios G. Hatzidimitriou and George Psomas
Inorganics 2024, 12(5), 138; https://doi.org/10.3390/inorganics12050138 (registering DOI) - 10 May 2024
Abstract
Three neutral nickel(II) complexes of 3,5–dibromo–salicylaldehyde (3,5–diBr–saloH) were synthesized in the presence or absence of 1,10–phenanthroline (phen) or its derivative 2,9–dimethyl–1,10–phenanthroline (neoc) as co–ligands, namely [Ni(3,5–diBr–salo)2(neoc)] (complex 1), [Ni(3,5–diBr–salo)2(phen)] (complex 2) and [Ni(3,5–diBr–salo)2(H2O) [...] Read more.
Three neutral nickel(II) complexes of 3,5–dibromo–salicylaldehyde (3,5–diBr–saloH) were synthesized in the presence or absence of 1,10–phenanthroline (phen) or its derivative 2,9–dimethyl–1,10–phenanthroline (neoc) as co–ligands, namely [Ni(3,5–diBr–salo)2(neoc)] (complex 1), [Ni(3,5–diBr–salo)2(phen)] (complex 2) and [Ni(3,5–diBr–salo)2(H2O)2] (complex 3), and were characterized by various techniques. The crystal structure of [Ni(3,5–diBr–salo)2(neoc)] was determined by single-crystal X-ray crystallography. According to employed studying techniques, the complexes interact tightly with calf-thymus DNA by an intercalative fashion. Furthermore, compounds 1–3 bind tightly and reversibly to human and bovine serum albumin. Full article
(This article belongs to the Special Issue Metal-Based Compounds: Relevance for the Biomedical Field)
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22 pages, 5877 KiB  
Article
Scenario-Based Green Infrastructure Installations for Building Urban Stormwater Resilience—A Case Study of Fengxi New City, China
by Yuyang Mao, Yu Li, Xinlu Bai, Xiaolu Yang, Youting Han and Xin Fu
Sustainability 2024, 16(10), 3990; https://doi.org/10.3390/su16103990 (registering DOI) - 10 May 2024
Abstract
Global climate change has precipitated a surge in urban flooding challenges, prompting the imperative role of green infrastructure (GI) as the linchpin of sponge city construction to enhance urban sustainability and resilience. But the evaluation of urban stormwater resilience faces challenges due to [...] Read more.
Global climate change has precipitated a surge in urban flooding challenges, prompting the imperative role of green infrastructure (GI) as the linchpin of sponge city construction to enhance urban sustainability and resilience. But the evaluation of urban stormwater resilience faces challenges due to the lack of a comprehensive evaluation framework taking the intrinsic features of the resilience system into account and the insufficient coverage of alternative scenarios’ performance under multiple rainfall return periods. This study, focusing on Fengxi New City, China, evaluates the suitability of GI (i.e., green roofs, rain gardens, and permeable pavements) and constructs a stormwater management model (SWMM) for urban stormwater hydrological simulation. This study also establishes a comprehensive urban stormwater resilience evaluation system and uses quantitative methods to unify the performances of scenarios under different rainfall return periods. Our analytical findings elucidate that the suitability of GI is predominantly concentrated in the northern and western areas of the study area, with the smallest suitable area observed for permeable pavements. Divergent GIs exhibit disparate performances, with rain gardens emerging as particularly efficacious. Importantly, the combination of multiple GIs yields a synergistic enhancement in resilience, underscoring the strategic advantage of adopting a diverse and integrated approach to GI implementation. This study facilitates a deeper understanding of urban stormwater resilience and assists in informed planning decisions for GI and sponge cities. Full article
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16 pages, 3019 KiB  
Review
A Review of the Structure–Property Relationship of Nickel Phosphides in Hydrogen Production
by Linyuan Chen and Xian-Kui Wei
Energies 2024, 17(10), 2294; https://doi.org/10.3390/en17102294 (registering DOI) - 10 May 2024
Abstract
Hydrogen, one of the most promising forms of new energy sources, due to its high energy density, low emissions, and potential to decarbonize various sectors, has attracted significant research attention. It is known that electrocatalytic hydrogen production is one of the most widely [...] Read more.
Hydrogen, one of the most promising forms of new energy sources, due to its high energy density, low emissions, and potential to decarbonize various sectors, has attracted significant research attention. It is known that electrocatalytic hydrogen production is one of the most widely investigated research directions due to its high efficiency in the conversion of electricity to H2 gas. However, given the limited reserves and high cost of precious metals, the search for non-precious metal-based catalysts has been widely explored, for example, transition metal phosphides, oxides, and sulfides. Despite this interest, a detailed survey unveils that the surface and internal structures of the alternative catalysts, including their surface reconstruction, composition, and electronic structure, are poorly studied. As a result, a disconnection in the structure–property relationship severely hinders the rational design of efficient and reliable non-precious metal-based catalysts. In this review, by focusing on Ni5P4, a bifunctional catalyst for water splitting, we systematically summarize the material motifs pertaining to the different synthetic methods, surface characteristics, and hydrolysis properties. It is believed that a cascaded correlation may provide insights toward understanding the fundamental catalytic mechanism and design of robust alternative catalysts for hydrogen production. Full article
(This article belongs to the Section A5: Hydrogen Energy)
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15 pages, 5122 KiB  
Article
Effect of Exogenous Organic Matter on Phosphorus Forms in Middle-High Fertility Cinnamon Soil
by Xiaodi Shi, Duanyin Gu, Haotian Yang, Yun Li, Yaqun Jiang, Nanbiao Zhan and Xiumin Cui
Plants 2024, 13(10), 1313; https://doi.org/10.3390/plants13101313 (registering DOI) - 10 May 2024
Abstract
Objectives: To slow down the chemical fixation of phosphate fertilizer, reduce the risk of active phosphorus leaching, stimulate the inherent phosphorus resource activity of soil, and improve phosphorus supply capacity. Methods: This study utilized a combination of field experiments and indoor chemical analysis. [...] Read more.
Objectives: To slow down the chemical fixation of phosphate fertilizer, reduce the risk of active phosphorus leaching, stimulate the inherent phosphorus resource activity of soil, and improve phosphorus supply capacity. Methods: This study utilized a combination of field experiments and indoor chemical analysis. Six types of exogenous organic matter (fulvic acid, biochar, compound microbial fertilizer, high-energy microbial inoculum, pig manure-vermicompost, cow manure-vermicompost) were added based on conventional fertilization. The experiment was conducted under the wheat-maize rotation system in the Huang-Huai-Hai region. Results: Compared with control (CK) without exogenous organic matter (EOM), all the other treatments with EOM had an enhancing effect on the available phosphorus of the cultivated soil. During the maize harvest, the combined application of biochar, pig manure-vermicompost and cow manure-vermicompost treatment significantly increased the content of available phosphorus in 0–20 cm soil by 45.87–56.59% compared with CK. The combined application of fulvic acid, biochar, pig manure-vermicompost and cow manure-vermicompost treatment significantly increased the content of Ca2-P in 0–20 cm soil by 34.04–65.14%. The content of Ca10-P in each treatment with EOM exhibited a lower level compared to CK. EOM could slow down the fixation of phosphorus to some degree. Correlation analysis revealed significant associations between Ca2-P, Ca8-P, Al-P, Fe-P, neutral phosphatase activity, acid phosphatase activity, and the available phosphorus content in the soil. The combined application of fulvic acid, biochar, and cow manure-vermicompost could enhance the activity of neutral and acid phosphatase in topsoil to a certain extent, thereby facilitating the conversion of phosphorus into highly available Ca2-P. EOM could enhance the soil phosphorus availability and decelerate the conversion of soil phosphorus into O-P and Ca10-P forms with low availability. Among all treatments, biochar exhibited the most pronounced efficiency in mitigating phosphorus leaching downward. Conclusions: All the EOMs had the potential to enhance the conversion of phosphorus into soluble phosphorus (Ca2-P), thereby mitigating the chemical fixation of soil phosphorus and ameliorating non-point source pollution caused by phosphorus. EOM enhanced the activity of neutral and acid phosphatase, which was beneficial to the conversion of organic phosphorus to inorganic phosphorus and increasing the content of available phosphorus. All EOMs had good effects on the retention of soil effective phosphorus, among which biochar had the best effect on retaining effective phosphorus in the tillage layer and blocking phosphorus leaching downward. Full article
(This article belongs to the Special Issue Advances in Plant Nutrition and Novel Fertilizers)
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22 pages, 18356 KiB  
Article
Multi-Objective Evcuation Planning Model Considering Post-Earthquake Fire Spread: A Tokyo Case Study
by Kai Tang and Toshihiro Osaragi
Sustainability 2024, 16(10), 3989; https://doi.org/10.3390/su16103989 (registering DOI) - 10 May 2024
Abstract
As an integral part of the 2030 Agenda for Sustainable Development, Disaster Risk Reduction (DRR) is essential for human safety and city sustainability. In recent years, natural disasters, which have had a tremendous negative impact on economic and social development, have frequently occurred [...] Read more.
As an integral part of the 2030 Agenda for Sustainable Development, Disaster Risk Reduction (DRR) is essential for human safety and city sustainability. In recent years, natural disasters, which have had a tremendous negative impact on economic and social development, have frequently occurred in cities. As one of these devastating disasters, earthquakes can severely damage the achievements of urban development and impact the sustainable development of cities. To prepare for potential large earthquakes in the future, efficient evacuation plans need to be developed to enhance evacuation efficiency and minimize casualties. Most previous research focuses on minimization of distance or cost while ignoring risk factors. We propose a multi-objective optimization model with the goal of reducing the risk during the evacuation process, which is called the risk reduction model (RRM). Problem-specific indicators for screening optimal solutions are introduced. The research selects the Ogu area in Tokyo as a case study, where there is a relatively high density of wooden structures, increasing the risks of building collapse and fire spread after an earthquake, and is based on a two-phase evacuation flow that considers secondary evacuation for fire response. The results indicate that, in this case, RRM can, in most situations, reduce the risk level during the evacuation process and improve evacuation efficiency and success rate without significantly increasing the total evacuation distance. It proves to be superior to the traditional distance minimization model (DMM), which prioritizes minimizing the total distance as the objective function. Full article
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20 pages, 2947 KiB  
Review
Tiny Organs, Big Impact: How Microfluidic Organ-on-Chip Technology Is Revolutionizing Mucosal Tissues and Vasculature
by Ishita Dasgupta, Durga Prasad Rangineni, Hasan Abdelsaid, Yixiao Ma and Abhinav Bhushan
Bioengineering 2024, 11(5), 476; https://doi.org/10.3390/bioengineering11050476 (registering DOI) - 10 May 2024
Abstract
Organ-on-chip (OOC) technology has gained importance for biomedical studies and drug development. This technology involves microfluidic devices that mimic the structure and function of specific human organs or tissues. OOCs are a promising alternative to traditional cell-based models and animals, as they provide [...] Read more.
Organ-on-chip (OOC) technology has gained importance for biomedical studies and drug development. This technology involves microfluidic devices that mimic the structure and function of specific human organs or tissues. OOCs are a promising alternative to traditional cell-based models and animals, as they provide a more representative experimental model of human physiology. By creating a microenvironment that closely resembles in vivo conditions, OOC platforms enable the study of intricate interactions between different cells as well as a better understanding of the underlying mechanisms pertaining to diseases. OOCs can be integrated with other technologies, such as sensors and imaging systems to monitor real-time responses and gather extensive data on tissue behavior. Despite these advances, OOCs for many organs are in their initial stages of development, with several challenges yet to be overcome. These include improving the complexity and maturity of these cellular models, enhancing their reproducibility, standardization, and scaling them up for high-throughput uses. Nonetheless, OOCs hold great promise in advancing biomedical research, drug discovery, and personalized medicine, benefiting human health and well-being. Here, we review several recent OOCs that attempt to overcome some of these challenges. These OOCs with unique applications can be engineered to model organ systems such as the stomach, cornea, blood vessels, and mouth, allowing for analyses and investigations under more realistic conditions. With this, these models can lead to the discovery of potential therapeutic interventions. In this review, we express the significance of the relationship between mucosal tissues and vasculature in organ-on-chip (OOC) systems. This interconnection mirrors the intricate physiological interactions observed in the human body, making it crucial for achieving accurate and meaningful representations of biological processes within OOC models. Vasculature delivers essential nutrients and oxygen to mucosal tissues, ensuring their proper function and survival. This exchange is critical for maintaining the health and integrity of mucosal barriers. This review will discuss the OOCs used to represent the mucosal architecture and vasculature, and it can encourage us to think of ways in which the integration of both can better mimic the complexities of biological systems and gain deeper insights into various physiological and pathological processes. This will help to facilitate the development of more accurate predictive models, which are invaluable for advancing our understanding of disease mechanisms and developing novel therapeutic interventions. Full article
(This article belongs to the Section Biomedical Engineering and Biomaterials)
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67 pages, 5953 KiB  
Review
N-Heterocycles as Promising Antiviral Agents: A Comprehensive Overview
by Gulraiz Ahmad, Maria Sohail, Muhammad Bilal, Nasir Rasool, Muhammad Usman Qamar, Codrut Ciurea, Luigi Geo Marceanu and Catalin Misarca
Molecules 2024, 29(10), 2232; https://doi.org/10.3390/molecules29102232 (registering DOI) - 10 May 2024
Abstract
Viruses are a real threat to every organism at any stage of life leading to extensive infections and casualties. N-heterocycles can affect the viral life cycle at many points, including viral entrance into host cells, viral genome replication, and the production of [...] Read more.
Viruses are a real threat to every organism at any stage of life leading to extensive infections and casualties. N-heterocycles can affect the viral life cycle at many points, including viral entrance into host cells, viral genome replication, and the production of novel viral species. Certain N-heterocycles can also stimulate the host’s immune system, producing antiviral cytokines and chemokines that can stop the reproduction of viruses. This review focused on recent five- or six-membered synthetic N-heterocyclic molecules showing antiviral activity through SAR analyses. The review will assist in identifying robust scaffolds that might be utilized to create effective antiviral drugs with either no or few side effects. Full article
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14 pages, 3636 KiB  
Article
Influence of Physical–Mechanical Strength and Water Absorption Capacity on Sawdust–Waste Paper–Recycled Plastic Hybrid Composite for Ceiling Tile Application
by Berhanu Tolessa Amena and Nazia Hossain
J. Compos. Sci. 2024, 8(5), 176; https://doi.org/10.3390/jcs8050176 (registering DOI) - 10 May 2024
Abstract
In recent times, there has been a notable surge in the interest in promoting environmentally conscious products, particularly within the building industry where the focus has shifted towards sustainable materials. In this study, as a sustainable building material, ceiling tiles have been fabricated [...] Read more.
In recent times, there has been a notable surge in the interest in promoting environmentally conscious products, particularly within the building industry where the focus has shifted towards sustainable materials. In this study, as a sustainable building material, ceiling tiles have been fabricated as a composite board containing waste materials, namely waste paper, sawdust, recycled polyethylene terephthalate (PET), and epoxy resin, and characterized comprehensively through physical and mechanical tests, density, thickness swelling (TS), modulus of elasticity (MOE), modulus of rupture (MOR), and flexural strength (FS) for product stability. A total of nine composites were fabricated with different ratios through molding techniques, and the characterization results were compared to determine the optimized stable ratio of composite composition. The composition of 25% waste paper, 15% sawdust, 10% recycled PET, and 50% epoxy resin presented the maximum FS compared to the other composite ratios. Water absorption (WA) and thickness swelling were evaluated after immersion durations of 1–24 h. The findings revealed that as the density increased, the sawdust content within the matrix decreased from 25–35%. Concurrently, an increase in recycled PET content resulted in decreased water absorption and thickness swelling. Significantly, the MOE, MOR, and FS demonstrated optimal values at 864.256 N/mm2, 12.786 N/mm2, and 4.64 MPa, respectively. These observations represent the excellent qualities of this hybrid composite board, particularly in terms of sustainability, stability, and water absorption capacity. Moreover, its lightweight nature and ability to support ceiling loads further enhance its appeal for construction applications. This study not only advances the discourse on sustainable construction materials but also fosters opportunities for broader acceptance and innovation within the industry. Full article
(This article belongs to the Special Issue Recycled Polymer Composites: Futuristic Sustainable Material)
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5 pages, 215 KiB  
Editorial
Therapeutic Uses and Efficacy of Botulinum Toxin in Orofacial Medicine: A Dental Perspective
by Kazuya Yoshida and Merete Bakke
Toxins 2024, 16(5), 220; https://doi.org/10.3390/toxins16050220 (registering DOI) - 10 May 2024
Abstract
Botulinum neurotoxin (BoNT) is the exotoxin of Clostridium botulinum, a Gram-positive, spore-forming bacterium [...] Full article
17 pages, 1774 KiB  
Article
Ecological Requirements for Abundance and Dispersion of Brazilian Yellow Fever Vectors in Tropical Areas
by Amanda Francisco Prado, Paula Ribeiro Prist, Luis Filipe Mucci and Patrícia Domingues de Freitas
Int. J. Environ. Res. Public Health 2024, 21(5), 609; https://doi.org/10.3390/ijerph21050609 (registering DOI) - 10 May 2024
Abstract
In the Americas, wild yellow fever (WYF) is an infectious disease that is highly lethal for some non-human primate species and non-vaccinated people. Specifically, in the Brazilian Atlantic Forest, Haemagogus leucocelaenus and Haemagogus janthinomys mosquitoes act as the major vectors. Despite transmission risk [...] Read more.
In the Americas, wild yellow fever (WYF) is an infectious disease that is highly lethal for some non-human primate species and non-vaccinated people. Specifically, in the Brazilian Atlantic Forest, Haemagogus leucocelaenus and Haemagogus janthinomys mosquitoes act as the major vectors. Despite transmission risk being related to vector densities, little is known about how landscape structure affects vector abundance and movement. To fill these gaps, we used vector abundance data and a model-selection approach to assess how landscape structure affects vector abundance, aiming to identify connecting elements for virus dispersion in the state of São Paulo, Brazil. Our findings show that Hg. leucocelaenus and Hg. janthinomys abundances, in highly degraded and fragmented landscapes, are mainly affected by increases in forest cover at scales of 2.0 and 2.5 km, respectively. Fragmented landscapes provide ecological corridors for vector dispersion, which, along with high vector abundance, promotes the creation of risk areas for WYF virus spread, especially along the border with Minas Gerais state, the upper edges of the Serra do Mar, in the Serra da Cantareira, and in areas of the metropolitan regions of São Paulo and Campinas. Full article
(This article belongs to the Section Environmental Health)
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16 pages, 2003 KiB  
Article
Loss of Conserved rRNA Modifications in the Peptidyl Transferase Center Leads to Diminished Protein Synthesis and Cell Growth in Budding Yeast
by Margus Leppik, Liisa Pomerants, Anett Põldes, Piret Mihkelson, Jaanus Remme and Tiina Tamm
Int. J. Mol. Sci. 2024, 25(10), 5194; https://doi.org/10.3390/ijms25105194 (registering DOI) - 10 May 2024
Abstract
Ribosomal RNAs (rRNAs) are extensively modified during the transcription and subsequent maturation. Three types of modifications, 2′-O-methylation of ribose moiety, pseudouridylation, and base modifications, are introduced either by a snoRNA-driven mechanism or by stand-alone enzymes. Modified nucleotides are clustered at the functionally important [...] Read more.
Ribosomal RNAs (rRNAs) are extensively modified during the transcription and subsequent maturation. Three types of modifications, 2′-O-methylation of ribose moiety, pseudouridylation, and base modifications, are introduced either by a snoRNA-driven mechanism or by stand-alone enzymes. Modified nucleotides are clustered at the functionally important sites, including peptidyl transferase center (PTC). Therefore, it has been hypothesised that the modified nucleotides play an important role in ensuring the functionality of the ribosome. In this study, we demonstrate that seven 25S rRNA modifications, including four evolutionarily conserved modifications, in the proximity of PTC can be simultaneously depleted without loss of cell viability. Yeast mutants lacking three snoRNA genes (snR34, snR52, and snR65) and/or expressing enzymatically inactive variants of spb1(D52A/E679K) and nop2(C424A/C478A) were constructed. The results show that rRNA modifications in PTC contribute collectively to efficient translation in eukaryotic cells. The deficiency of seven modified nucleotides in 25S rRNA resulted in reduced cell growth, cold sensitivity, decreased translation levels, and hyperaccurate translation, as indicated by the reduced missense and nonsense suppression. The modification m5C2870 is crucial in the absence of the other six modified nucleotides. Thus, the pattern of rRNA-modified nucleotides around the PTC is essential for optimal ribosomal translational activity and translational fidelity. Full article
(This article belongs to the Special Issue Advanced Studies in Ribosomal RNA)
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20 pages, 7143 KiB  
Article
An Open-Source Supervisory Control and Data Acquisition Architecture for Photovoltaic System Monitoring Using ESP32, Banana Pi M4, and Node-RED
by Wei He, Mirza Jabbar Aziz Baig and Mohammad Tariq Iqbal
Energies 2024, 17(10), 2295; https://doi.org/10.3390/en17102295 (registering DOI) - 10 May 2024
Abstract
To overcome the issues of the existing properties and the non-configurable supervisory control and data acquisition (SCADA) architecture, this paper proposes an IoT-centered open-source SCADA system for monitoring photovoltaic (PV) systems. The system consists of three voltage sensors and three current sensors for [...] Read more.
To overcome the issues of the existing properties and the non-configurable supervisory control and data acquisition (SCADA) architecture, this paper proposes an IoT-centered open-source SCADA system for monitoring photovoltaic (PV) systems. The system consists of three voltage sensors and three current sensors for data accumulation from the PV panel, the battery, and the load. As a part of the system design, a relay is used that controls the load remotely. An ESP32-E microcontroller transmits the collected data to a Banana Pi M4 Berry (BPI-M4 Berry) through the Message Queuing Telemetry Transport (MQTT) protocol over a privately established communication channel using Wi-Fi. The ESP32-E is configured as the MQTT publisher and the BPI-M4 Berry serves as the MQTT broker. Locally installed on the BPI-M4 Berry, the Node-RED platform creates highly customizable dashboards as human–machine interfaces (HMIs) to achieve real-time monitoring of the PV system. The proposed system was successfully tested to collect the PV system voltage/current/power data and to control the load in a supervisory way under a laboratory setup. The complete SCADA architecture details and test results for the PV system data during the total eclipse on 8 April 2024 and another day are presented in this paper. Full article
(This article belongs to the Section A2: Solar Energy and Photovoltaic Systems)
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9 pages, 2765 KiB  
Case Report
A Difficult Case of Ventriculitis in a 40-Year-Old Woman with Acute Myeloid Leukemia
by Raffaella Rubino, Marcello Trizzino, Luca Pipitò, Giuseppe Sucato, Marco Santoro, Rosario Maugeri, Domenico Gerardo Iacopino, Giovanni Maurizio Giammanco, Sergio Siragusa and Antonio Cascio
Antibiotics 2024, 13(5), 432; https://doi.org/10.3390/antibiotics13050432 (registering DOI) - 10 May 2024
Abstract
Ventriculitis and nosocomial meningitis caused by carbapenem-resistant Gram-negative and vancomycin-resistant Gram-positive bacteria represent a growing treatment challenge. A case of ventriculitis and bacteremia caused by carbapenem-resistant, KPC-producing Klebsiella pneumoniae and vancomycin-resistant Enterococcus faecium in a young woman with acute leukemia who was successfully [...] Read more.
Ventriculitis and nosocomial meningitis caused by carbapenem-resistant Gram-negative and vancomycin-resistant Gram-positive bacteria represent a growing treatment challenge. A case of ventriculitis and bacteremia caused by carbapenem-resistant, KPC-producing Klebsiella pneumoniae and vancomycin-resistant Enterococcus faecium in a young woman with acute leukemia who was successfully treated with meropenem/vaborbactam (MVB), rifampicin, and linezolid is described in this paper. This case report emphasizes the importance of a multidisciplinary strategy, including infectious focus control, for the treatment of device-associated central nervous system (CNS) infections from multidrug-resistant bacteria. Considering the novel resistance patterns, more research on drug penetration into the central nervous system, as well as on the necessity of association therapies, is needed. Full article
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19 pages, 3389 KiB  
Article
Exploring Nitric Oxide as a Regulator in Salt Tolerance: Insights into Photosynthetic Efficiency in Maize
by Georgi D. Rashkov, Martin A. Stefanov, Ekaterina K. Yotsova, Preslava B. Borisova, Anelia G. Dobrikova and Emilia L. Apostolova
Plants 2024, 13(10), 1312; https://doi.org/10.3390/plants13101312 (registering DOI) - 10 May 2024
Abstract
The growing issue of salinity is a significant threat to global agriculture, affecting diverse regions worldwide. Nitric oxide (NO) serves as an essential signal molecule in regulating photosynthetic performance under physiological and stress conditions. The present study reveals the protective effects of different [...] Read more.
The growing issue of salinity is a significant threat to global agriculture, affecting diverse regions worldwide. Nitric oxide (NO) serves as an essential signal molecule in regulating photosynthetic performance under physiological and stress conditions. The present study reveals the protective effects of different concentrations (0–300 µM) of sodium nitroprusside (SNP, a donor of NO) on the functions of the main complexes within the photosynthetic apparatus of maize (Zea mays L. Kerala) under salt stress (150 mM NaCl). The data showed that SNP alleviates salt-induced oxidative stress and prevents changes in the fluidity of thylakoid membranes (Laurdan GP) and energy redistribution between the two photosystems (77K chlorophyll fluorescence ratio F735/F685). Chlorophyll fluorescence measurements demonstrated that the foliar spray with SNP under salt stress prevents the decline of photosystem II (PSII) open reaction centers (qP) and improves their efficiency (Φexc), thereby influencing QA reoxidation. The data also revealed that SNP protects the rate constants for two pathways of QA reoxidation (k1 and k2) from the changes caused by NaCl treatment alone. Additionally, there is a predominance of QA interaction with plastoquinone in comparison to the recombination of electrons in QA QB with the oxygen-evolving complex (OEC). The analysis of flash oxygen evolution showed that SNP treatment prevents a salt-induced 10% increase in PSII centers in the S0 state, i.e., protects the initial S0–S1 state distribution, and the modification of the Mn cluster in the OEC. Moreover, this study demonstrates that SNP-induced defense occurs on both the donor and acceptor sides of the PSII, leading to the protection of overall photosystems performance (PIABS) and efficient electron transfer from the PSII donor side to the reduction of PSI end electron acceptors (PItotal). This study clearly shows that the optimal protection under salt stress occurs at approximately 50–63 nmoles NO/g FW in leaves, corresponding to foliar spray with 50–150 µM SNP. Full article
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9 pages, 1867 KiB  
Brief Report
Targeted Tick-Borne Disease Recognition: Assessing Risk for Improved Public Health
by Pyung Kim, Sarah Maxwell, Nabila Parijat, Dohyeong Kim and Connie L. McNeely
Healthcare 2024, 12(10), 984; https://doi.org/10.3390/healthcare12100984 (registering DOI) - 10 May 2024
Abstract
Tick-borne diseases (TBDs) pose a rapidly growing threat to public health. The incidence of TBDs is on the rise, necessitating a comprehensive understanding of the risk factors beyond demographic considerations. This brief report combines a preliminary review of the literature with geographical case [...] Read more.
Tick-borne diseases (TBDs) pose a rapidly growing threat to public health. The incidence of TBDs is on the rise, necessitating a comprehensive understanding of the risk factors beyond demographic considerations. This brief report combines a preliminary review of the literature with geographical case mapping to identify the various factors influencing TBD risk. The report highlights the vulnerability of outdoor workers, the importance of outdoor activities, and the role of education in adopting preventive behaviors. Pet ownership and interactions with animals are also associated with an increased risk. The state of Illinois is used as a case study for this report, revealing regional variations in TBD incidence, and linking them to agricultural practices, forested areas, and park accessibility. These findings inform recommendations for targeted prevention strategies, emphasizing the need for detailed geographical data to enhance public health efforts in curbing TBD incidence and risk. Full article
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