Background/Objective: Diet is a risk factor for gestational diabetes mellitus (GDM). There are few studies on women’s diet and glucose tolerance test (GTT) results during pregnancy. The objective of this study was to evaluate the relationship between one’s previous diet and the number of abnormal values on the diagnostic GTT in women with GDM. We hypothesized that there would be an inverse relation between antioxidant micronutrient consumption and the number of abnormal GTT values. Methods: This cross-sectional study included 60 women diagnosed with GDM (2-h, 75 g-GTT), divided in two groups as follows: 1 abnormal glucose value and 2-3 abnormal values. Shortly after the diagnosis, participants answered a validated food frequency questionnaire to assess their food consumption in the last 6 months. The Mann–Whitney test was used to compare the dietary intake of the participants in the two groups. Results: The participant characteristics were similar. The median intake of total calories, carbohydrates, lipids, and proteins did not differ significantly between groups. Participants with 1 abnormal GTT value had significantly higher intakes of fiber (11.9 vs. 11.0 g/day p = 0.049), vitamin D (40.6 vs. 40.4 mcg/day p = 0.049), and vitamin C (180.0 vs. 151.0 mg/day p = 0.008) than those with 2-3 abnormal values. Conclusions: Our results suggest a possible association between the consumption of fiber and antioxidant micronutrients and the number of abnormal GTT values. Full article

Digital weight loss interventions present a viable and cost-effective alternative to traditional therapy. However, further evidence is needed to establish the equal effectiveness of both approaches. This randomized controlled non-inferiority trial aimed to compare the effects of an intensive in-person weight loss intervention program with Vitadio digital therapy. One hundred patients with obesity and diagnosed with type 2 diabetes, prediabetes, or insulin resistance were enrolled and randomly assigned to one of the two treatment groups. Over a 6-month period, the control group received five in-person consultations with a physician who specialized in obesity treatment, a dietitian and/or a nutrition nurse, while the intervention group followed the digital program based on a multimodal therapeutic approach. The extent of weight loss was assessed and compared between the groups. Additionally, changes in body composition and metabolic parameters for the digital intervention group were analyzed. The study results demonstrated comparable effectiveness of both treatments for weight reduction. The positive effects of Vitadio were further evidenced by favorable changes in body composition and lipid metabolism and improved glycemic control in the intervention group. These findings suggest that Vitadio is an effective tool for assisting patients with managing obesity and preventing diabetes progression. Full article

(1) Background: Since multiple sclerosis (MS) is a neurological pathology known for its disabling effects across many domains, the introduction of virtual reality (VR) usage has been attempted, as it represents a new method of approach to rehabilitation and treatment of chronic neurological pathologies. Encouraging research has explored the use of video game consoles and VR-assisted Robot-Assisted Gait Training (RAGT) to address balance disturbances in this population. (2) Methods: The search involved two databases, Web of Science and PubMed, utilizing a selection of terms including “Virtual reality”, “Multiple sclerosis”, “Balance”, and “Rehabilitation”. Two reviewers initiated and performed the search for articles, subsequently selecting and extracting data from the studies. The PEDro scale was the tool for evaluating the quality of the articles that we introduced in our research. (3) Results: After rigorous scanning, nine articles remained eligible for our study. VR interventions, particularly compared to standard balance training, consistently improved balance in multiple sclerosis. Robotic-assisted technology with 2D VR yielded superior results in balance rehabilitation. VR interventions had varied effects on walking speed. They have shown promise in decreasing the risk of falls and improving patients’ daily lives while reducing fatigue in multiple sclerosis. (4) Conclusions: VR offers comparable or superior benefits to classical exercise and no intervention for balance but does not significantly improve functional mobility. However, it shows the potential to improve quality of life and fatigue in MS patients. Investigation of VR alongside RAGT is important to be performed with larger sample sizes and comprehensive results are needed to fully understand its efficacy in MS rehabilitation. Full article

The BTB (broad-complex, tramtrack, and bric-a-brac) domain, also known as the POZ (POX virus and zinc finger) domain, is a conserved protein–protein interaction domain present in various organisms. In this study, we conducted a genome-wide search to identify and characterize BTB genes in Solanum tuberosum. A total of 57 StBTBs were identified and analyzed for their physicochemical properties, chromosomal distribution, gene structure, conserved motifs, phylogenetic relationships, tissue-specific expression patterns, and responses to hormonal and stress treatments. We found that StBTBs were unevenly distributed across potato chromosomes and exhibited diverse gene structures and conserved motifs. Tissue-specific expression analysis revealed differential expression patterns across various potato tissues, implying their roles in plant growth and development. Furthermore, differential expression analysis under hormonal and stress treatments indicated the involvement of StBTBs in abiotic and biotic stress responses and hormone signaling pathways. Protein–protein interaction analysis identified potential interactions with ribosomal proteins, suggesting roles in translational regulation. Additionally, microRNA target site analysis revealed regulatory relationships between StBTBs and miRNAs. Our study provides a comprehensive understanding of the StBTB gene family in potato, laying the groundwork for further functional characterization and manipulation of these genes to improve stress tolerance and agricultural productivity in potato and related plant species. Full article

The transdermal delivery of non-steroidal anti-inflammatory drugs (NSAIDs) has the potential to overcome some of the major disadvantages relating to oral NSAID usage, such as gastrointestinal adverse events and compliance. However, the poor solubility of many of the newer NSAIDs creates challenges in incorporating the drugs into formulations suitable for application to skin and may limit transdermal permeation, particularly if the goal is therapeutic systemic drug concentrations. This review is an overview of the various strategies used to increase the solubility of poorly soluble NSAIDs and enhance their permeation through skin, such as the modification of the vehicle, the modification of or bypassing the barrier function of the skin, and using advanced nano-sized formulations. Furthermore, the simple yet highly versatile microemulsion system has been found to be a cost-effective and highly successful technology to deliver poorly water-soluble NSAIDs. Full article

Background: Cytokine storm and oxidative stress are present in chronic obstructive pulmonary disease (COPD). Individuals with COPD present high levels of NF-κB-associated cytokines and pro-oxidant agents as well as low levels of Nrf2-associated antioxidants. This condition creates a steroid-resistant inflammatory microenvironment. Lacticaseibacillus rhamnosus (Lr) is a known anti-cytokine in lung diseases; however, the effect of Lr on lung inflammation and oxidative stress in steroid-resistant COPD mice remains unknown. Objective: Thus, we investigated the Lr effect on lung inflammation and oxidative stress in mice and macrophages exposed to cigarette smoke extract (CSE) and unresponsive to steroids. Methods: Mice and macrophages received dexamethasone or GLPG-094 (a GPR43 inhibitor), and only the macrophages received butyrate (but), all treatments being given before CSE. Lung inflammation was evaluated from the leukocyte population, airway remodeling, cytokines, and NF-κB. Oxidative stress disturbance was measured from ROS, 8-isoprostane, NADPH oxidase, TBARS, SOD, catalase, HO-1, and Nrf2. Results: Lr attenuated cellularity, mucus, collagen, cytokines, ROS, 8-isoprostane, NADPH oxidase, and TBARS. Otherwise, SOD, catalase, HO-1, and Nrf2 were upregulated in Lr-treated COPD mice. Anti-cytokine and antioxidant effects of butyrate also occurred in CSE-exposed macrophages. GLPG-094 rendered Lr and butyrate less effective. Conclusions: Lr attenuates lung inflammation and oxidative stress in COPD mice, suggesting the presence of a GPR43 receptor-dependent mechanism also found in macrophages. Full article

Myelodysplastic syndrome (MDS) is a clonal disease derived from hematopoietic stem cells, characterized by ineffective hematopoiesis (resulting in peripheral blood cytopenia) and an increased risk of transformation into acute myeloid leukemia. MDS is caused by a complex combination of genetic mutations resulting in a heterogeneous genotype. Genetic studies have identified a set of aberrations that play a central role in the pathogenesis of MDS. In this article, we present a clinical case of MDS transformation into acute myeloid leukemia in the context of two cell lines exhibiting morphological, immunophenotypic, and dysmyelopoiesis markers and the presence of two heterozygous mutations in the TET2 gene. Full article

Obesity is primarily exacerbated by excessive lipid accumulation during adipogenesis, with triacylglycerol (TG) as a major lipid marker. However, as the association between numerous lipid markers and various health conditions has recently been revealed, investigating the lipid metabolism in detail has become necessary. This study investigates the lipid metabolic effects of Hydrangea serrata (Thunb.) Ser. hot water leaf extract (WHS) on adipogenesis using LC-MS-based lipidomics analysis of undifferentiated, differentiated, and WHS-treated differentiated 3T3-L1 cells. WHS treatment effectively suppressed the elevation of glycerolipids, including TG and DG, and prevented a molecular shift in fatty acyl composition towards long-chain unsaturated fatty acids. This shift also impacted glycerophospholipid metabolism. Additionally, WHS stabilized significant lipid markers such as the PC/PE and LPC/PE ratios, SM, and Cer, which are associated with obesity and related comorbidities. This study suggests that WHS could reduce obesity-related risk factors by regulating lipid markers during adipogenesis. This study is the first to assess the underlying lipidomic mechanisms of the adipogenesis-inhibitory effect of WHS, highlighting its potential in developing natural products for treating obesity and related conditions. Our study provides a new strategy for the development of natural products for the treatment of obesity and related diseases. Full article

With technological development and the decrease in the price of electrical appliances for domestic consumers, combined with users’ desire for a certain level of comfort, the number of electrical devices in homes has increased. Although current equipment is largely energy-efficient, the high number of these devices, used simultaneously, has led to an increase in electricity consumption. Electrical installation in homes has been replaced in most cases, but the connections have remained the same, without any checks being carried out in terms of load and operational safety. This paper presents an exploratory case study based on a questionnaire answered by 678 individuals from Romania. The objectives of the questionnaire were to identify the characteristics of the domestic consumer and their opinion on the state of the installation, energy costs, and energy consumption. Based on the analysis, 74.15% of the respondents stated that the power installed in their homes as domestic consumers increased. Based on the analysis conducted on-site, the risk of fire outbreaks in the power supply columns of apartment buildings was identified. To avoid critical situations, it is necessary to periodically check the connection and supply columns so that they are functional and safe to operate. Full article

The design of 3D scenes is of great significance, and one of the crucial areas is interior scene design. This study not only pertains to the living environment of individuals but also has applications in the design and development of virtual environments. Previous work on indoor scenes has focused on understanding and editing existing indoor scenes, such as scene reconstruction, segmentation tasks, texture, object localization, and rendering. In this study, we propose a novel task in the realm of indoor scene comprehension, amalgamating interior design principles with professional evaluation criteria: 3D indoor scene design assessment. Furthermore, we propose an approach using a transformer encoder–decoder architecture and a dual-graph convolutional network. Our approach facilitates users in posing text-based inquiries; accepts input in two modalities, point cloud representations of indoor scenes and textual queries; and ultimately generates a probability distribution indicating positive, neutral, and negative assessments of interior design. The proposed method uses separately pre-trained modules, including a 3D visual question-answering module and a dual-graph convolutional network for identifying emotional tendencies of text. Full article

Most traditional synthetic dyes and functional reagents used in silk fabrics are not biodegradable and lack green environmental protection. Natural dyes have attracted more and more attention because of their coloring, functionalization effects, and environmental benefits. In this study, natural dyes were extracted from lac and used for coloring and functionalization in silk fabrics without any other harmful dyes. The extraction conditions were studied and analyzed by the univariate method. The optimal extraction process was that the volume ratio of ethanol to water was 60:40 with a solid–liquid ratio of 1:10, and reacting under the neutrality condition for 1 h at 70 °C. Silk fabric can be dyed dark owing to the certain lifting property of lac. After being dyed by Al³⁺ post-medium, the levels of the washing fastness, light fastness, and friction fastness of silk fabric are all above four with excellent fastness. The results show that the dyed silk fabrics have good UV protection, antioxidation, and antibacterial properties. The UV protection coefficient UPF is 42.68, the antioxidant property is 98.57%, and the antibacterial property can reach more than 80%. Therefore, the dyeing and functionalization of silk fabrics by utilizing naturally lac dyes show broad prospects in terms of the application of green sustainable dyeing and functionalization. Full article

With the system interconnection and intelligence of application scenario equipment, the electromagnetic environment of chips is becoming more and more complex. Problems such as communication interruption and data loss caused by electromagnetic interference often occur. The electromagnetic reliability of chips has become an important index to measure their availability. In order to effectively detect the electromagnetic reliability of industrial chips applied to specific scenarios, it is necessary to measure and analyze the electromagnetic characteristics of the application scenarios, as the boundary conditions of the electromagnetic protection simulation analysis and design of the chip, and to develop Electromagnetic Compatibility (EMC) test items, test limits and test methods suitable for carrying out tests and monitoring on chips. The paper presents an acquisition system, which can complete the collection of transient electromagnetic interference, steady electromagnetic field, temperature, humidity and near-field data. The transient interference measurement frequency range is 300 kHz–500 MHz, with a rising edge of 1.5 ns; the steady-state electromagnetic field measurement frequency ranges from 100 Hz to 3 GHz. By collecting the electromagnetic environmental characteristics of chips and analyzing situations in which chips are prone to interference, protective measures can be implemented. Full article

This study investigated the influence and mechanism of the excavation width on excavation deformations in Shanghai soft clay. Based on three excavations that had different final excavation depths, dissimilar retaining structures and diverse geological conditions, 40 sets of two-dimensional numerical models with different excavation widths were employed to analyze the deformation rules affected by the excavation width. Moreover, a series of simplified models with different excavation widths were employed to analyze the effect of the excavation width on excavation deformations. The results show that under the same excavation depth, both the horizontal displacements of the retaining walls and ground surface settlements increase as the excavation width increases, but the increasing rate gradually decreases. Factors such as the unloading influence depth, the overlap degree of the passive zones, the stress state of the basal soils and the development of the relative shear stress have a significant influence on excavation deformations. With increasing excavation width, the unloading influence depth gradually deepens, the overlap area of the passive zones gradually decreases, the direction of the rotation of the major principal stress gradually reduces and the relative shear stress of the distant and deep soils gradually expands. Therefore, the constraint ability of the passive zones on excavation deformation gradually reduces and excavation deformations gradually increase. Full article

Magnonics is an emerging field within spintronics that focuses on developing novel magnetic devices capable of manipulating information through the modification of spin waves in nanostructures with submicron size. Here, we provide a confined magnetic rectangular element to modulate the standing spin waves, by changing the saturation magnetisation (M_S), exchange constant (A), and the aspect ratio of rectangular magnetic elements via micromagnetic simulation. It is found that the bulk mode and the edge mode of the magnetic element form a hybrid with each other. With the decrease in M_S, both the Kittel mode and the standing spin waves undergo a shift towards higher frequencies. On the contrary, as A decreases, the frequencies of standing spin waves become smaller, while the Kittel mode is almost unaffected. Moreover, when the length-to-width aspect ratio of the element is increased, standing spin waves along the width and length become split, leading to the observation of additional modes in the magnetic spectra. For each mode, the vibration style is discussed. These spin dynamic modes were further confirmed via FMR experiments, which agree well with the simulation results. Full article

The study assesses the direct effects of climate change by 2060, including extreme events, on the productivity of regional crop farming and livestock in Greece, and the broader socio-economic effects on the agri-food and other sectors. Different approaches (i.e., agronomic models, statistical regression models, and equations linking thermal stress to livestock output) were combined to estimate the effects on productivity from changes in the average values of climatic parameters, and subsequently the direct economic effects from this long-term climate change. Recorded damages from extreme events together with climatic thresholds per event and crop were combined to estimate the direct economic effects of these extremes. The broader socio-economic effects were then estimated through input–output analysis. Under average levels of future extreme events, the total direct economic losses for Greek agriculture due to climate change will be significant, from EUR 437 million/year to EUR 1 billion/year. These losses approximately double when indirect effects on other sectors using agricultural products as inputs (e.g., food and beverage, hotels, and restaurants) are considered, and escalate further under a tenfold impact of extreme events. Losses in the GDP and employment are moderate at the national level, but significant in regions where the contribution of agriculture is high. Full article

The licensing of new reactors implies the use of verified and validated neutronic codes. Numerical validation can rely on sensitivity and uncertainty studies, but they require repeated execution of time-consuming neutron flux and depletion calculations. The computational costs can be reduced by using perturbation theories. However, the uncoupled Depletion Perturbation Theory is restricted to single integral values such as nuclide density. Relying on reduced-basis approaches, which reconstruct all nuclide densities at once, is one way to get around this restriction. Furthermore, the adjoint-based reduced-order model uses the direct and adjoint equations for projection. For diffusion or transport calculations, the Exact-to-Precision Generalized Perturbation Theory was developed. Still, no models for depletion calculations are readily available. Therefore, this paper describes a novel adjoint-based reduced-order model for the Bateman Equation. It uses a range-finding algorithm to create the basis and the uncoupled Depletion Perturbation Theory for the reconstruction of the first order replaced by with a first order formulation. Our paper shows that for several perturbed cases, the depletion reduced-order model successfully reconstructs the nuclide densities. As a result, this serves as a proof of concept for our adjoint-based reduced-order model, which can perform sensitivity and uncertainty burn-up analysis in a shorter time. Full article

In this paper, a solar thermochemical reactor is designed based on a 5 kW non-coaxial concentrating solar simulator, and a mathematical model is established for thermal calculations. The calculated temperature distribution is used as a load condition for thermal stress analyses. The model is used to study the influence of the solar simulator power, solar reactor inner wall material’s emissivity, working pressure, gas inlet velocity, and thermocouple opening diameter on the thermal stress of the solar reactor. The results show that thermal stress increases with the increase in solar simulator power and the emissivity of the inner wall material in the solar reactor. The inlet velocity and working pressure have little effect on the thermal stress of the reactor and cannot prevent damage to the reactor. In the case of maintaining the diameter of the thermocouple at the front end of the reactor, increasing the diameter of the thermocouple inside the reactor leads to an increase in thermal stress around the reactor. Meanwhile, using a finer thermocouple can reduce the thermal stress inside the reactor and extend its service life, which will provide a foundation for designing practical industrial applications in the future. Full article

Every year, a significant amount of pepper stalks are wasted due to low utilization. The ash produced from pepper stalks contains a significant amount of alkaline salts, which are food additives that can enhance the quality of noodles. Therefore, utilizing natural pepper straw ash to improve the quality of noodles shows promising development prospects. In this study, pepper straw ash leachate (PSAL) was extracted and added to noodles. The quality of the noodles gradually improved with the addition of PSAL, with the best effect observed at a concentration of 18% (PSAL mass/flour mass). This addition resulted in a 57.8% increase in noodle hardness, a 55.43% increase in chewiness, a 19.41% rise in water absorption rate, and a 13.28% increase in disulfide bond content. These alterations rendered the noodles more resilient during cooking, reducing their tendency to soften and thus enhancing chewiness and palatability. Incorporating PSAL also reduced cooking loss by 57.79%. Free sulfhydryl groups decreased by 5.1%, and scanning electron microscopy revealed a denser gluten network structure in the noodles, with more complete starch wrapping. This study significantly enhanced noodle quality and provided a new pathway for the application of pepper straw resources in the food industry. Full article

Habitat quality is an important basis for human well-being and the achievement of sustainable development. Based on land-use data for the Bosten Lake Basin in 2000, 2005, 2010, 2015, and 2022, the PLUS and InVEST models are applied in this study to predict and analyze land-use changes and explore the spatial and temporal evolution characteristics of the region’s habitat quality. Additionally, we use a geographic detector model to reveal the drivers of spatial variation in habitat quality. The results show that: (1) Land use in Bosten Lake Basin is dominated by grassland and bare land, with an area share of 93.21%. Habitat quality shows a trend of degradation followed by improvement, with a spatial pattern of high in the northwest and low in the southeast. (2) Habitat quality in 2030 increased from 2022 in all cases, with a mean of 0.354 for the natural development scenario, a maximum of 0.355 for the ecological development scenario, and a minimum of 0.353 for the economic development scenario. (3) The main drivers affecting habitat quality in the Bosten Lake watershed are DEM, mean annual precipitation (MAP), and GDP per capita. X1∩X4 (0.50) and X4∩X10 (0.51) are the interaction factors with the largest dominant effect in 2000, 2010 and 2020, respectively. Full article

Heat stress is one of the stressors that negatively affect broiler chickens, leading to a reduction in production efficiency and profitability. This reduction affects the economy in general, especially in hot and semi-hot countries. Therefore, improving heat tolerance of broiler chicks is a key to sustained peak performance, especially under adverse environmental heat stress conditions. The present study investigated three early feed withdrawal regimes (FWD) as a potential mitigation for thermal stress exposure. A total of 240 unsexed one-day-old Cobb-500 chicks were randomly recruited to one of four experimental groups using a completely randomized design (10 birds × 6 replicates). The experimental groups included the control group with no feed withdrawal (control), while the other three groups were subjected to early feed withdrawal for either 24 h on the 5th day of age (FWD-24), 12 h on the 3rd and 5th day of age (FWD-12), or 8 h on the 3rd, 4th, and 5th day of age (FWD-8), respectively. Production performance was monitored throughout the experiment. Meanwhile, blood and liver samples were taken at the end of the experimental period to evaluate major physiological dynamic changes. Our findings demonstrated that under chronic heat stress conditions, FWD treatments significantly improved broilers’ production performance and enhanced several physiological parameters compared with the control. Serum levels of thyroid hormones were elevated, whereas leptin hormone was decreased in FWD groups compared with the control. Moreover, serum total protein, globulin, and hemoglobin levels were higher, while total cholesterol and uric acid were lower in the FWD groups. Furthermore, FWD groups showed significantly higher antioxidant marker activity with a significantly lower lipid peroxidation level. Immunoglobulin levels, lysozyme, complement factor C3, and liver heat shock protein 70 (HSP70) concentration were also elevated in FWD compared with the control. Also, serum interleukin-1β (IL-1β) and interferon-gamma (IFN-γ) significantly increased with FWD. Based on our findings, early feed withdrawal can be applied as a promising non-invasive nutritional strategy for broilers reared under chronic heat stress conditions. Such a strategy promotes the alleviation of the deleterious effects of heat stress on broiler performance, immunity, and redox status, owing to the onset of physiological adaptation and the development of thermotolerance ability. Full article

The effects of submerged plant-induced calcium and phosphorus coprecipitation on the phosphorus cycle in aquatic environments and interspecific differences are still unclear. Herein, we selected Ceratophyllum demersum L. and Potamogeton crispus L. to construct a sediment–water-submerged plant system. We examined how phosphorus concentrations in the water, sediment, and plant ash changed over time with different phosphorus and calcium treatments and explored the effects of photosynthesis-induced calcium and phosphorus coprecipitation on water’s phosphorus cycle and variations between different submerged plant species. The main results were as follows: (1) The phosphorus reduction in the P. crispus system was less than that in the C. demersum system. (2) P. crispus had higher total ash phosphorus (TAP) values than C. demersum. (3) The sediment total phosphorus (STP) and its fractions with P. crispus were most affected by phosphorus concentration while those with C. demersum were most affected by time. Overall, the two submerged species exhibited different calcium and phosphorus coprecipitation levels and had distinct effects on the water-to-phosphorus cycle. When submerged plants are introduced to reduce and stabilize the phosphorus levels, plant interspecific differences in their induced calcium and phosphorus coprecipitation on water and phosphorus cycling must be fully assessed. Full article

The small intestine is important to the digestion and absorption of rumen undegradable nutrients, as well as the barrier functionality and immunological responses in ruminants. Oxidative stress induces a spectrum of pathophysiological symptoms and nutritional deficits, causing various gastrointestinal ailments. Previous studies have shown that nicotinamide (NAM) has antioxidant properties, but the potential mechanism has not been elucidated. The aim of this study was to explore the effects of NAM on hydrogen peroxide (H₂O₂)-induced oxidative injury in bovine intestinal epithelial cells (BIECs) and its potential mechanism. The results showed that NAM increased the cell viability and total antioxidant capacity (T-AOC) and decreased the release of lactate dehydrogenase (LDH) in BIECs challenged by H₂O₂. The NAM exhibited increased expression of catalase, superoxide dismutase 2, and tight junction proteins. The expression of autophagy-related proteins was increased in BIECs challenged by H₂O₂, and NAM significantly decreased the expression of autophagy-related proteins. When an autophagy-specific inhibitor was used, the oxidative injury in BIECs was not alleviated by NAM, and the T-AOC and the release of LDH were not affected. Collectively, these results indicated that NAM could alleviate oxidative injury in BIECs by enhancing antioxidant capacity and increasing the expression of tight junction proteins, and autophagy played a crucial role in the alleviation. Full article