Oxytocin, a significant pleiotropic neuropeptide, regulates psychological stress adaptation and social communication, as well as peripheral actions, such as uterine contraction and milk ejection. Recently, a Japanese Kampo medicine called Kamikihito (KKT) has been reported to stimulate oxytocin neurons to induce oxytocin secretion. Two-pore-domain potassium channels (K2P) regulate the resting potential of excitable cells, and their inhibition results in accelerated depolarization that elicits neuronal and endocrine cell activation. We assessed the effects of KKT and 14 of its components on a specific K2P, the potassium channel subfamily K member 2 (TREK-1), which is predominantly expressed in oxytocin neurons in the central nervous system (CNS). KKT inhibited the activity of TREK-1 induced via the channel activator ML335. Six of the 14 components of KKT inhibited TREK-1 activity. Additionally, we identified that 22 of the 41 compounds in the six components exhibited TREK-1 inhibitory effects. In summary, several compounds included in KKT partially activated oxytocin neurons by inhibiting TREK-1. The pharmacological effects of KKT, including antistress effects, may be partially mediated through the oxytocin pathway. Full article

Synthetic aperture radar tomography (TomoSAR) is an extension of synthetic aperture radar (SAR) imaging. It introduces the synthetic aperture principle into the elevation direction to achieve three-dimensional (3-D) reconstruction of the observed target. Compressive sensing (CS) is a favorable technology for sparse elevation recovery. However, for the non-sparse elevation distribution of the forested areas, if CS is selected to reconstruct it, it is necessary to utilize some orthogonal bases to first represent the elevation reflectivity sparsely. The iterative adaptive approach (IAA) is a non-parametric algorithm that enables super-resolution reconstruction with minimal snapshots, eliminates the need for hyperparameter optimization, and requires fewer iterations. This paper introduces IAA to tomographicinversion of the forested areas and proposes a novel multi-polarimetric-channel joint 3-D imaging method. The proposed method relies on the characteristics of the consistent support of the elevation distribution of different polarimetric channels and uses the $L_2$-norm to constrain the IAA-based 3-D reconstruction of each polarimetric channel. Compared with typical spectral estimation (SE)-based algorithms, the proposed method suppresses the elevation sidelobes and ambiguity and, hence, improves the quality of the recovered 3-D image. Compared with the wavelet-based CS algorithm, it reduces computational cost and avoids the influence of orthogonal basis selection. In addition, in comparison to the IAA, it demonstrates greater accuracy in identifying the support of the elevation distribution in forested areas. Experimental results based on BioSAR 2008 data are used to validate the proposed method. Full article

The main purpose of this article is to identify and classify smart and sustainable urban mobility solutions in the context of three narratives for sustainable mobility: electromobility, collective transport 2.0 and low-mobility societies. The research process of this study included the following methods: review of the literature, namely, strategic European documents, sustainable urban mobility plans in chosen cities and scientific publications addressing smart and sustainable mobility, case studies of selected cities in Europe and technology mapping to visualize the study results. The main result of this study is the review of various smart and sustainable urban solutions (SSUM) and their classification within the three narratives of electromobility, collective transport 2.0 and low-mobility societies. This article expands the concept of the three narratives for sustainable mobility with the aspect of smart mobility enriched with the variety of example solutions, case studies and good practices within mobility strategies in European cities. The study results can be useful for different stakeholders engaged in developing and introducing the sustainable mobility strategies in cities. Based on the catalogue of SSUM solutions, presented case studies and good practices, they may gain the necessary knowledge, consider the possible initiatives towards green transformation in cities and finally adjust them to the citizens’ need. Full article

Oligodontia can be isolated or syndromic, associated with other ectodermal abnormalities. The aim of the study was to perform hair examination in orthodontic patients diagnosed with oligodontia with a low clinical expression of symptoms of ectodermal origin. All available orthodontic patients diagnosed with oligodontia in the permanent dentition were enrolled. Hair examination included clinical evaluation of the patients’ hair, trichoscopy, trichogram and evaluation of the hair shafts under a polarized light microscope. In total, 25 patients, 18 males and 7 females, aged 6 to 24 years were evaluated for the presence of dental and hair abnormalities. The number of congenitally absent teeth ranged from 6 to 24 teeth and diastemas, microdontia, taurodontism and altered tooth shape were found in 23 patients. Hair disorders were found in 68% of the subjects. Hypotrichosis, the heterogeneity of shaft color and loss of pigment, androgenetic alopecia, telogen effluvium, trichoschisis, pili canaliculi, trichorrhexis nodosa and pseudomoniletrix were observed. Trichoscopy and trichogram are valid non-invasive diagnostic tests which could be used to differentiate between isolated and syndromic oligodontia in patients with a low clinical expression of ectodermal symptoms. Full article

Age estimation is a critical aspect of reconstructing a biological profile in forensic sciences. Diverse biochemical processes have been studied in their correlation with age, and the results have driven DNA methylation to the forefront as a promising biomarker. DNA methylation, an epigenetic modification, has been extensively studied in recent years for developing age estimation models in criminalistics and forensic anthropology. Epigenetic clocks, which analyze DNA sites undergoing hypermethylation or hypomethylation as individuals age, have paved the way for improved prediction models. A wide range of biomarkers and methods for DNA methylation analysis have been proposed, achieving different accuracies across samples and cell types. This review extensively explores literature from the past 5 years, showing scientific efforts toward the ultimate goal: applying age prediction models to assist in human identification. Full article

A neutral Polygonatum cyrtonema polysaccharide (NPCP) was isolated and purified from Polygonatum cyrtonema by various chromatographic techniques, including DEAE-52 and Sephadex-G100 chromatography. The structure of NPCP was characterized by HPLC, HPGPC, GC-MS, FT-IR, NMR, and SEM. Results showed that NPCP is composed of glucose (55.4%) and galactose (44.6%) with a molecular weight of 3.2 kDa, and the sugar chain of NPCP was →1)-α-D-Glc-(4→1)-β-D-Gal-(3→. In vitro bioactivity experiments demonstrated that NPCP significantly enhanced macrophages proliferation and phagocytosis while inhibiting the M1 polarization induced by LPS as well as the M2 polarization induced by IL-4 and IL-13 in macrophages. Additionally, NPCP suppressed the secretion of IL-6 and TNF-α in both M1 and M2 cells but promoted the secretion of IL-10. These results suggest that NPCP could serve as an immunomodulatory agent with potential applications in anti-inflammatory therapy. Full article

The main objective of this study was to evaluate the reliability of Garmin Vivofit^® Jr. physical activity (PA) wristbands during daily life physical activities. Six wristbands were randomly selected from a stock of twenty-four. The wristbands were worn by a single four-year-old participant, with three on the right wrist area and three on the left wrist area. To assess device reliability under laboratory conditions on a treadmill (Powerjog, model JM200, SportEngineering Ltd., Birmingham, UK), the participant wore the six wristbands while performing five work conditions: sitting and standing (30 times per minute, controlled by a metronome), walking at 3 km/h, walking at 4 km/h, running at 5 km/h, and running at 6 km/h. Throughout the six minutes, variables related to physical activity provided by the device, step volume, and minutes of physical activity were recorded using the specific application of the wristband (Garmin International Inc., Olathe, KS, USA). The intraclass correlation coefficients (ICCs) were high for all six wristbands with each other, for both the number of steps taken (ICC = 0.991–0.998) and the number of minutes of PA (ICC = 0.892–0.977). The critical alpha value of the Cusum test was highest at.050 for all wristband associations. In conclusion, good reliability was found among the six wristbands, which could be adopted for field-based research to quantify physical activities. Full article

In this paper, we present a study investigating the impact of jamming in a Dual-Hop free-space optical (FSO) communication system assisted by reconfigurable intelligent surfaces (RIS) in the presence of a malicious jammer. We analyze the combined effects of atmospheric turbulence (AT), pointing error (PE), and angle of arrival (AoA) fluctuation of unmanned aerial vehicles (UAVs). Closed-form expressions for the overall average bit error rate (ABER) are derived while considering these impairments. To mitigate the jamming effect, we explore a Single-Input Multiple-Output (SIMO) FSO system and derive the end-to-end Average Bit Error Rate (ABER) under various jamming scenarios. Additionally, we conduct a comprehensive study by examining different placements of the malicious UAV jammer and RIS, drawing insightful conclusions on system performance. The analytically derived expressions are validated through Monte Carlo simulations. Full article

The genus Angelica comprises various species utilized for diverse medicinal purposes, with differences attributed to the varying levels or types of inherent chemical components in each species. This study employed DNA barcode analysis and HPLC analysis to genetically authenticate and chemically classify eight medicinal Angelica species (n = 106) as well as two non-medicinal species (n = 14) that have been misused. Nucleotide sequence analysis of the nuclear internal transcribed spacer (ITS) region revealed differences ranging from 11 to 117 bp, while psbA-trnH showed variances of 3 to 95 bp, respectively. Phylogenetic analysis grouped all samples except Angelica sinensis into the same cluster, with some counterfeits forming separate clusters. Verification using the NCBI database confirmed the feasibility of species identification. For chemical identification, a robust quantitative HPLC analysis method was developed for 46 marker compounds. Subsequently, two A. reflexa-specific and seven A. biserrata-specific marker compounds were identified, alongside non-specific markers. Moreover, chemometric clustering analysis reflecting differences in chemical content between species revealed that most samples formed distinct clusters according to the plant species. However, some samples formed mixed clusters containing different species. These findings offer crucial insights for the standardization and quality control of medicinal Angelica species. Full article

Long-term preventive maintenance planning using finite annual budgets is vital for maintaining the service performance of airport runway composite pavements. Using the pavement condition index (PCI) to quantify composite pavement performance, this study investigated the PCI deterioration tendencies of middle runways, terminal runways, and taxiways and developed prediction models related to structural thickness and air traffic. Performance jump (PJ) and deterioration rate reduction (DRR) were used to measure maintenance benefits. Based on 112 composite pavement sections in the Long-term Pavement Performance Program, this study analyzed the influences of five typical preventive maintenance technologies on PJ, DRR, and PCI deterioration rates. The logarithmic regression relationship between PJ and PCI was obtained. For sections treated with crack sealing and crack filling, the DRR was nearly 0. For sections treated with fog seal, thin HMA overlay, and hot-mix recycled AC, the DRR was 0.2, 0.7, and 0.8, respectively. To solve the multi-objective maintenance problem, this study proposed a decision-making optimization method based on dynamic programming, and the solution algorithm was optimized, which was applied in a five-year maintenance plan. Considering different PCI deterioration tendencies of airport regions, as well as PJ, DRR, and costs of maintenance technologies, the preventive maintenance decision-making optimization method meets performance and financial requirements sufficiently. Full article

This paper proposes a novel approach to audio game design by introducing the concept of speech puzzles (spuzzles) to describe the utilisation of recorded voice for the creation of audio puzzles in ways that challenge players’ different listening modes. In the fields of audio games and audio-interactive applications, speech serves instructive, descriptive, narrative, and in some cases—in the form of hints or quizzes—gameplay purposes by addressing users through language. The suggested approach of spuzzles extends this potential by including, besides encoded meaning, the acoustic properties of sound, thus engaging the user’s causal and reduced listening modes in parallel with the semantic listening mode. An audio game consisting of four inherently different spuzzles was designed as proof of concept and tested by seven third-year students of Audiovisual Arts, who elaborated on their experience through a focus group semi-structured discussion. Despite their difficulty, the spuzzles were well accepted by most of the participants (5/7), whereas all participants agreed on their acoustic richness, need for concentration, and independence from pre-existing musical knowledge. Therefore, the authors suggest that the proposed design approach could serve as a paradigm for future research in the design of complex audio-based game mechanics. Full article

This paper proposes a reinforcement learning method using a deep residual shrinkage network based on multi-reward priority experience playback for high-frequency and high-dimensional continuous vibration control. Firstly, we keep the underlying equipment unchanged and construct a vibration system simulator using FIR filters to ensure the complete fidelity of the physical model. Then, by interacting with the simulator using our proposed algorithm, we identify the optimal control strategy, which is directly applied to real-world scenarios in the form of a neural network. A multi-reward mechanism is proposed to assist the lightweight network to find a near-optimal control strategy, and a priority experience playback mechanism is used to prioritize the data to accelerate the convergence speed of the neural network and improve the data utilization efficiency. At the same time, the deep residual shrinkage network is introduced to realize adaptive denoising and lightweightness of the neural network. The experimental results indicate that under narrowband white-noise excitation ranging from 0 to 100 Hz, the DDPG algorithm achieved a vibration reduction effect of 12.728 dB, while our algorithm achieved a vibration reduction effect of 20.240 dB. Meanwhile, the network parameters were reduced by more than 7.5 times. Full article

Disturbances often occur in transfer stations; however, little is known about the weaknesses of transfer stations and their ability to cope with passenger flows. Therefore, this paper introduces resilience into the study of transfer stations to enhance their emergency response processes and improve the sustainability of URT networks. It establishes a two-level fuzzy evaluation model, using the G1 weighting method, to assess resilience across various scenarios (daily operation, heavy passenger flow, and emergencies) and identify weaknesses; then, corresponding enhancement strategies are proposed. First, factor sets are established according to resilience stages, including rapidity before disturbance, robustness, redundancy, resourcefulness, and rapidity after disturbance. Using the G1 method, the weight matrix for each factor is calibrated, and a membership degree matrix is determined based on their affiliation with the review set. Multiplying the weight matrix and membership degree matrix yields the resilience value. We apply these steps to a representative station with the assistance of Anylogic simulation in calculating the hard-to-obtain data, yielding a peak-hour resilience value of 0.3425, which indicates a “poor” rating in the review set. By combining the peak-hour resilience with resilience curves under different multiples of peak-hour flows, an enhancement prioritization strategy is proposed for the station, which can act as a reference for the management of URT transfer stations. Full article

The chlorination mechanism of neodymium oxide for the production of anhydrous neodymium chloride was analyzed based on the reaction temperature and reaction ratio of ammonium chloride, considering the suppression of the generation of NdOCl, an intermediate product of the reaction process. The results were obtained by distinguishing the shape of the produced NdCl₃ (powder and bulk) and the setup of the chlorination equipment, reflecting its sensitivity to moisture and oxygen. The powdered form of NdCl₃ produced at 400 °C and under argon gas flow was identified as NdCl₃·6(H₂O), while the bulk form of NdCl₃ produced by melting at 760 °C after a chlorination process consisted of anhydrous NdCl₃ and NdCl₃∙n(H₂O). The powdered NdCl₃ produced in an argon gas environment with a controlled level of oxygen (below 16.05 ppm) and moisture (below 0.01 ppm) content was identified as single-phase anhydrous NdCl₃ and showed the highest chlorination conversion rate of 98.65%. The addition of overstoichiometric ratios of NH₄Cl in the chlorination process decreased the total amount of impurities (N, H, and O) in the NdCl₃ product and increased the conversion rate of NdCl₃. Full article

Currently, the use of modern technologies, such as UAVs, allows for a detailed analysis of the protection of Sites of Cultural Interest (BICs) in Spain. Cala Castle in Huelva is selected for this study, which is one of the most important medieval fortifications in the mountainous region and was rehabilitated between 2003 and 2011. After a decade of its architectural rehabilitation, the use of this new UAV technology will allow the creation of a database of the property and its surroundings, made up of a series of 3D models and photogrammetric studies of the territory. This analysis allows us two complementary readings to the original study: on the one hand, to characterize the natural and landscape context of Cala Castle, and on the other, to identify the pre-existence of a series of historic buildings, which have historically articulated this region. The 3D models obtained provide relevant graphic information. The current state of the BIC allows this space to be considered for reactivation as a social space at the regional level. The visuals of the regional environment allow us to identify that the most recent growth has been articulated longitudinally along the N-630 highway, this infrastructure being the backbone of the nucleus. As a pilot test, the beginning of this graphic and visual database (3D) at a regional level will provide a valuable tool for the conservation and registration of built heritage, given that it seeks to incorporate other fortifications that make up Banda Gallega with the aim of defining a sustainable development strategy at county level. Full article

The mineralization of soil organic carbon (SOC) is a critical process in the soil carbon cycle. This study aimed to investigate the vertical distribution characteristics and mineralization dynamics of SOC in soils and their aggregates across different steppe types in the Loess Plateau (LP). Soil profiles from three steppe types under varying precipitation gradients were selected: meadow steppe (MS), typical steppe (TS), and desert steppe (DS). A 60-day controlled laboratory incubation study was conducted for carbon mineralization and the influence of climatic and soil properties on SOC mineralization was analyzed. The results showed that the SOC content and cumulative mineralization (C_M) in 1–2 mm aggregates were higher than in other particle sizes; SOC content and C_M followed the order MS > TS > DS and both decreased significantly with increasing soil depth. Correlation analysis revealed that precipitation significantly affected aggregate mineralization (p < 0.001) and that mineralization in the 1–2 mm aggregates was more closely related to mean annual precipitation (MAP), SOC, and water-soluble organic carbon (SWOC). Precipitation primarily controlled SOC mineralization in the 0–50 cm soil layer, while SOC mineralization in the 50–100 cm layer was influenced by soil-related carbon content. Structural Equation Modeling indicated that precipitation influences the mineralization of organic carbon in topsoil indirectly through its direct impact on SOC. In the context of global warming, the SOC turnover rate in high-precipitation areas (MS) was faster than in low-precipitation areas (TS, DS), necessitating greater attention to soil carbon dynamics in these regions. Full article

Soil moisture is among the most essential variables in hydrology and earth science. Many satellite missions, such as AMSR-E/2, have been launched to observe it in broader spatial coverage to overcome the shortage of in situ observations. However, the satellite soil moisture products have been reported to comprise errors caused by the so-called “temperature effects” widely observed in dielectrically measured in situ volumetric soil water content (SWC). In this work, we confirmed the existence of these errors in AMSR2 soil moisture products. A new algorithm was developed to remove these errors using satellite data at ascending and descending overpasses. The application of this algorithm to both satellite and in situ data of SWC and soil temperature at the Mongolia site shows that the difference between SWC values at ascending and descending overpasses caused by temperature effects is effectively removed. We assess the impact of this removal method on satellite data by comparing it with in situ data, utilizing metrics such as the correlation coefficient and other widely adopted evaluation methods. It is shown that the difference between the original and corrected in situ SWC is much smaller than that between AMSR2 and in situ SWC, either corrected or not. The results indicate that the metric values between the corrected AMSR2 and in situ SWC, after removing apparent differences caused by temperature effects, slightly improved compared to those between the original AMSR2 and in situ SWC. Though these findings imply that the removed errors may not be the most dominant, considering the current significant difference between AMSR2 and in situ SWC, the removal makes the ascending and descending data have close characteristics. It may allow using data at both ascending and descending overpasses and double the temporal resolution of AMSR2 SWC data. Full article

Size exclusion chromatography with total organic carbon detection (HPSEC-TOC) is a widely employed technique for characterizing aquatic natural organic matter (NOM) into high, medium, and low molecular weight fractions. This study validates the suitability of HPSEC-TOC for a simplified yet efficient routine analysis of freshwater and its application within drinking water treatment plants. The investigation highlights key procedural considerations for optimal results and shows the importance of sample preservation by refrigeration with a maximum storage duration of two weeks. Prior to analysis, the removal of inorganic carbon is essential, which is achieved without altering the NOM composition through sample acidification to pH 6 and subsequent N₂-purging. The chromatographic separation employs a preparative TSK HW-50S column to achieve a limit of detection of 19.0 µgC dm⁻³ with an injection volume of 1350 mm⁻³. The method demonstrates linearity up to 10 000 µgC dm⁻³. Precision, trueness and recovery assessments are conducted using certified reference materials, model compounds, and real water samples. The relative measurement uncertainty in routine analysis ranges from 3.22% to 5.17%, while the measurement uncertainty on the bias is 8.73%. Overall, the HPSEC-TOC represents a reliable tool for NOM fractions analysis in both treated and untreated ground and surface water. Full article

This review focuses on recent research on the phytochemicals found in bark from different trees and their potential to be used as substrates for the synthesis of thermosetting resins. Recent studies about the influence of each bark harvesting step on the extracted phytochemicals, from debarking to extraction, are investigated. A comparison of bark extracts in terms of the correlation between extraction conditions and efficiency (based on the total phenolic content (TPC) and extraction yield) is presented for six groups of trees (Norway spruce, pine species, other conifers, oak species, other deciduous trees of the north temperate zone, tropical and subtropical trees) and evaluated. The evaluation revealed that there is an interesting relationship between the extraction time and the type of solvent for some types of tree bark. It was found that a relatively short extraction time and a solvent temperature close to the boiling point are favourable. The latest research on the application of bark extracts in different types of thermosetting resins is described. This review discusses the attractiveness of bark extracts in terms of functional groups and the possibilities arising from extractable phytochemicals. In addition, different approaches (selective versus holistic) and methods of application are presented and compared. Full article

Improving crop yield and resource utilization efficiency is essential for agricultural productivity. In the Huang-Huai-Hai maize region of China, optimizing planting density, nitrogen (N) application, and fertilization methods are key strategies for enhancing maize yield and N use efficiency. However, traditional approaches have often hindered these improvements. To address this issue, we conducted a study in Baoding, Hebei, from 2022 to 2023, focusing on planting density, the N application rate, and the fertilization method on grain yield, N use efficiency, water use efficiency (WUE), and economic benefits. The trial involved two planting densities: 6.0 × 10⁴ plants ha⁻¹ (D1, typical local density) and 9.0 × 10⁴ plants ha⁻¹ (D2). Five N application rates were tested: 0 (N0), 120 kg ha⁻¹ (N1), 180 kg ha⁻¹ (N2), 240 kg ha⁻¹ (N3), and 300 kg ha⁻¹ (N4). The control treatment (D1N4) utilized the local planting density and traditional fertilization methods. Our findings revealed a positive correlation between the maize yield and N application rate, with the maximum yields (13.78–13.88 t ha⁻¹), high WUE (24.42–29.85 kg m⁻³), agronomic efficiency of N (AE_N) (18.11–19.00 kg kg⁻¹), and economic benefits (2.44 × 10⁴–2.47 × 10⁴ CNY ha⁻¹) observed with D2N3 and surface drip fertilization. This was significantly higher than the yield and resource efficiency of traditional fertilization methods and saved fertilizer and production costs. Therefore, adopting surface drip fertilization, adjusting planting density, and optimizing N application rates proved effective in enhancing maize yield and resource utilization efficiency in the Huang-Huai-Hai maize region. Full article

This study provides an empirical test of a previously proposed assertion that intelligence as adaptation has an attitudinal as well as an ability component. The ability component deals with what the basic knowledge and skills are that underlie intelligence, and how much of each one an individual has. The attitudinal component deals with how an individual chooses to deploy the abilities they have. In other words, to what use are the abilities put? It is argued that it is impossible fully to separate the measurement of the ability component from the attitudinal one. In a diverse population, even taking an intelligence test will show itself to involve an attitude toward the test, which may enhance or detract from performance, as when one sees the test as irrelevant or harmful to one’s life, or as a sociocultural misfit to one’s life experience. To succeed, people need not only to have abilities, but attitudes that put those abilities to effective use to accomplish individuals’ life goals. In the study, we found that intelligent attitudes are related, but non-identical, to germane constructs, such as wisdom, the need for cognition, creativity, and openness to experience. Scores on the attitudinal measure were not related to scores on tests of fluid intelligence and academic abilities/achievement. Thus, the range of attitudes regarding how to deploy intelligence can vary over ability levels. Full article