The 2023 MDPI Annual Report has
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13 pages, 898 KiB  
Article
Exploring In Vitro Immunomodulatory Properties of Moss Atrichum undulatum Extracts
by Tanja Lunić, Marija Rakić, Aneta Sabovljević, Marko Sabovljević, Tamara Filipović, Bojan Božić and Biljana Božić Nedeljković
Plants 2024, 13(10), 1349; https://doi.org/10.3390/plants13101349 (registering DOI) - 13 May 2024
Abstract
Bryophytes are rich sources of diverse secondary metabolites with a wide range of biological activities, including anti-inflammatory, antitumor and antimicrobial effects. The aim of this study was to investigate the chemical composition of extracts from two different genotypes (Serbian and Hungarian) of the [...] Read more.
Bryophytes are rich sources of diverse secondary metabolites with a wide range of biological activities, including anti-inflammatory, antitumor and antimicrobial effects. The aim of this study was to investigate the chemical composition of extracts from two different genotypes (Serbian and Hungarian) of the axenic moss Atrichum undulatum and evaluate the immunomodulatory potential of the prepared extracts in vitro. Both genotypes of moss samples were cultivated in vitro and subsequently extracted in a Soxhlet apparatus with methanol or ethyl acetate. The highest concentration of total phenolic compounds was found in the methanolic extract of the Serbian genotype (54.25 mg GAE/g extract), while the ethyl acetate extract of the Hungarian genotype showed the highest concentration of phenolic acids (163.20 mg CAE/extract), flavonoids (35.57 mg QE/extract), and flavonols (2.25 mg QE/extract). The extracts showed anti-neuroinflammatory properties by reducing the production of reactive oxygen species, nitric oxide, and tumor necrosis factor alpha by lipopolysaccharide-stimulated microglial cells. Moreover, they mitigated the cytotoxic effects of the pro-inflammatory mediators produced by activated microglia on neurons. The data obtained suggest that extracts from A. undulatum moss have promising anti-neuroinflammatory and neuroprotective properties, making them interesting candidates for further research to combat neuroinflammation. Full article
19 pages, 1884 KiB  
Review
Use of Natural Zeolite Clinoptilolite in the Preparation of Photocatalysts and Its Role in Photocatalytic Activity
by Jelena Pavlović and Nevenka Rajić
Minerals 2024, 14(5), 508; https://doi.org/10.3390/min14050508 (registering DOI) - 13 May 2024
Abstract
The use of natural zeolite clinoptilolite in preparing photocatalysts and its function in photocatalysis are discussed in this review. The importance of advanced oxidation processes (AOPs) and the potential of heterogeneous photocatalysis in removing environmental pollutants are emphasized. The review focuses on the [...] Read more.
The use of natural zeolite clinoptilolite in preparing photocatalysts and its function in photocatalysis are discussed in this review. The importance of advanced oxidation processes (AOPs) and the potential of heterogeneous photocatalysis in removing environmental pollutants are emphasized. The review focuses on the synergistic effects of clinoptilolite with semiconductors (TiO2, ZnO, CuO, SnO2, and NiO) to prepare stable and active photocatalysts, highlighting recent advancements in this field. It explores clinoptilolite’s structural characteristics, highlighting its microporous nature, adaptable framework, and improved textural properties due to acid and alkali treatments. Particle size, crystal phase, and calcination temperature are three key synthesis parameters that affect photocatalytic activity and are highlighted in the discussion of these parameters and their methods. A discussion is held regarding the processes and mechanisms of photocatalytic degradation of different organic compounds under varying irradiation conditions, including UV, visible, and ambient sunlight. Clinoptilolite is vital in improving supported semiconductor oxides’ photocatalytic efficiencies, which aid in pollutant degradation and environmental remediation. Full article
11 pages, 1191 KiB  
Article
Exploring the Impact of Humic Biostimulants on Cassava Yield and Nutrition in Northeast Brazil
by Maisa da Conceição Santos, Mônica Tejo Cavalcanti, Larissa Nicácio Pessoa, Zenaide Gomes da Silva, Allisson Miguel da Silva, Tancredo Souza, Juliane Maciel Henschel, Emmanuel Moreira Pereira, Manoel Alexandre Diniz Neto and Belísia Lúcia Moreira Toscano Diniz
Sustainability 2024, 16(10), 4088; https://doi.org/10.3390/su16104088 (registering DOI) - 13 May 2024
Abstract
Cassava is a staple food mainly produced with low management inputs, causing soil depletion and low yields. The use of organic inputs, such as humic substances (HSs), represents a sustainable alternative to increase cassava growth and production, mainly in semi-arid regions such as [...] Read more.
Cassava is a staple food mainly produced with low management inputs, causing soil depletion and low yields. The use of organic inputs, such as humic substances (HSs), represents a sustainable alternative to increase cassava growth and production, mainly in semi-arid regions such as the Brazilian Northeast. Thus, the objective was to evaluate the foliar application of a biostimulant based on humic substances on the morphophysiology, production, and mineral nutrient contents of cassava. The biofortified cultivar BRS Dourada was grown under field conditions and foliar application of a biostimulant based on humic substances (BHSs, treated plants) or water (untreated, control). The experiment was conducted in a randomized block design with four repetitions. At 225 days after planting, the growth, productivity, and mineral nutrient contents of soil, roots, and leaves were determined. No differences between treated and untreated plants were found for growth and productivity (average 15.2 t ha−1). On the other hand, BHS treatment reduced net carbon assimilation, water use efficiency, and carboxylation efficiency by 34%, 24%, and 47%, respectively. Moreover, BHS treatment reduced nutrient uptake from soil, and Na and K contents in roots and leaves, respectively. A foliar BHS application is not recommended for cassava production in the conditions evaluated here. Full article
(This article belongs to the Special Issue Sustainable Soil Management and Crop Production Research)
14 pages, 439 KiB  
Article
Ill, but Still Attractive? The Impact of Mental Illness on Attractiveness Perceptions and Social Judgment
by Nilüfer Aydin, Miriam Clivia Plewe, Luisa Afra Malin Mahr and Janet Kleber
Behav. Sci. 2024, 14(5), 406; https://doi.org/10.3390/bs14050406 (registering DOI) - 13 May 2024
Abstract
In line with the “beautiful-is-good” heuristic, numerous studies show that physically attractive individuals are perceived in a more positive light. However, building on previous findings suggesting that the “beauty–good” relationship is bidirectional, the present research investigates how information on a stigmatized attribute impacts [...] Read more.
In line with the “beautiful-is-good” heuristic, numerous studies show that physically attractive individuals are perceived in a more positive light. However, building on previous findings suggesting that the “beauty–good” relationship is bidirectional, the present research investigates how information on a stigmatized attribute impacts attractiveness perceptions and social judgments. Within a controlled experimental design, we present evidence that the mere label of mental illness (i.e., schizophrenia) decreased the positivity of personality evaluations and perceived attractiveness of a male target that had previously been validated to be highly attractive. Consistent with the “good-is-beautiful” heuristic, a mental illness label led to decreased perceptions of attractiveness, which was mediated by the inference of less positive personality characteristics. This finding lends further support for the bidirectional nature of the “beauty–good” relationship and provides a valuable avenue for future research on the multifaceted ways in which the stigma of mental illness affects social perceptions. Full article
(This article belongs to the Section Social Psychology)
22 pages, 2855 KiB  
Article
Test Coverage in Microservice Systems: An Automated Approach to E2E and API Test Coverage Metrics
by Amr S. Abdelfattah, Tomas Cerny, Jorge Yero, Eunjee Song and Davide Taibi
Electronics 2024, 13(10), 1913; https://doi.org/10.3390/electronics13101913 (registering DOI) - 13 May 2024
Abstract
Test coverage is a critical aspect of the software development process, aiming for overall confidence in the product. When considering cloud-native systems, testing becomes complex, as it becomes necessary to deal with multiple distributed microservices that are developed by different teams and may [...] Read more.
Test coverage is a critical aspect of the software development process, aiming for overall confidence in the product. When considering cloud-native systems, testing becomes complex, as it becomes necessary to deal with multiple distributed microservices that are developed by different teams and may change quite rapidly. In such a dynamic environment, it is important to track test coverage. This is especially relevant for end-to-end (E2E) and API testing, as these might be developed by teams distinct from microservice developers. Moreover, indirection exists in E2E, where the testers may see the user interface but not know how comprehensive the test suits are. To ensure confidence in health checks in the system, mechanisms and instruments are needed to indicate the test coverage level. Unfortunately, there is a lack of such mechanisms for cloud-native systems. This manuscript introduces test coverage metrics for evaluating the extent of E2E and API test suite coverage for microservice endpoints. It elaborates on automating the calculation of these metrics with access to microservice codebases and system testing traces, delves into the process, and offers feedback with a visual perspective, emphasizing test coverage across microservices. To demonstrate the viability of the proposed approach, we implement a proof-of-concept tool and perform a case study on a well-established system benchmark assessing existing E2E and API test suites with regard to test coverage using the proposed endpoint metrics. The results of endpoint coverage reflect the diverse perspectives of both testing approaches. API testing achieved 91.98% coverage in the benchmark, whereas E2E testing achieved 45.42%. Combining both coverage results yielded a slight increase to approximately 92.36%, attributed to a few endpoints tested exclusively through one testing approach, not covered by the other. Full article
(This article belongs to the Special Issue Software Analysis, Quality, and Security)
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11 pages, 325 KiB  
Article
Selenium and Arsenic Levels, Prevalence of Common Variants of Genes Involved in Their Metabolism, and Psoriasis Disease
by Tadeusz Dębniak, Piotr Baszuk, Ewa Duchnik, Karolina Rowińska, Emilia Rogoża-Janiszewska, Magdalena Boer, Magdalena Kiedrowicz, Mariola Marchlewicz, Daniel Watola, Martyna Feherpataky, Róża Derkacz, Anna Dębniak, Wojciech Marciniak, Katarzyna Gołębiewska, Jan Lubiński, Rodney J. Scott and Jacek Gronwald
Biomedicines 2024, 12(5), 1082; https://doi.org/10.3390/biomedicines12051082 (registering DOI) - 13 May 2024
Abstract
Using an Inductively Coupled Plasma Mass Spectrometer we measured the concentration of selenium and arsenic in serum and blood samples from 336 unselected psoriatic patients and 336 matched healthy controls to evaluate any associations with the clinical course of the disease. We genotyped [...] Read more.
Using an Inductively Coupled Plasma Mass Spectrometer we measured the concentration of selenium and arsenic in serum and blood samples from 336 unselected psoriatic patients and 336 matched healthy controls to evaluate any associations with the clinical course of the disease. We genotyped 336 patients and 903 matched controls to evaluate the prevalence of SOD2 (rs4880), CAT (rs1001179), GPX1 (rs1050450), and DMGDH (rs921943) polymorphisms using Taqman assays. The mean selenium (Se) level in serum was 74 µg/L in patients and 86 µg/L in controls (p < 0.001). The mean Se level in blood was 95 µg/L in patients and 111 µg/L in controls (p < 0.001). Psoriasis risk was greatest among participants with the lowest serum (<68.75 µg/L, OR: 8.30; p < 0.001) and lowest blood concentrations of Se (<88.04 µg/L, OR: 10.3; p < 0.001). Similar results were observed in subgroups of males and females. We found an inverse correlation of selenium levels with PASI, NAPSI, and BSA scores. There was no significant difference in the distribution of the CAT, GPX1, DMGDH, and SOD2 polymorphisms. Among carriers of rs4880, rs1001179, and rs921943 polymorphisms, blood selenium levels were significantly lower. The mean arsenic level in serum was 0.79 µg/L in patients and 0.7 µg/L in controls (p = 0.2). The mean concentration in blood was 1.1 µg/L in patients and 1.3 µg/L in controls (p < 0.001). In conclusion, we found that lower selenium levels, in blood and serum, are associated with psoriasis risk and its more severe course. Future prospective studies should focus on the optimalisation of the concentration of this trace element not only for prophylactic guidance but also to support the treatment of this disease. Full article
(This article belongs to the Section Molecular Genetics and Genetic Diseases)
18 pages, 1353 KiB  
Article
Bone Regenerative Effect of Injectable Hypoxia Preconditioned Serum-Fibrin (HPS-F) in an Ex Vivo Bone Defect Model
by Jun Jiang, Lynn Röper, Finja Fuchs, Marc Hanschen, Sandra Failer, Sarah Alageel, Xiaobin Cong, Ulf Dornseifer, Arndt F. Schilling, Hans-Günther Machens and Philipp Moog
Int. J. Mol. Sci. 2024, 25(10), 5315; https://doi.org/10.3390/ijms25105315 (registering DOI) - 13 May 2024
Abstract
Biofunctionalized hydrogels are widely used in tissue engineering for bone repair. This study examines the bone regenerative effect of the blood-derived growth factor preparation of Hypoxia Preconditioned Serum (HPS) and its fibrin-hydrogel formulation (HPS-F) on drilled defects in embryonic day 19 chick femurs. [...] Read more.
Biofunctionalized hydrogels are widely used in tissue engineering for bone repair. This study examines the bone regenerative effect of the blood-derived growth factor preparation of Hypoxia Preconditioned Serum (HPS) and its fibrin-hydrogel formulation (HPS-F) on drilled defects in embryonic day 19 chick femurs. Measurements of bone-related growth factors in HPS reveal significant elevations of Osteopontin, Osteoprotegerin, and soluble-RANKL compared with normal serum (NS) but no detection of BMP-2/7 or Osteocalcin. Growth factor releases from HPS-F are measurable for at least 7 days. Culturing drilled femurs organotypically on a liquid/gas interface with HPS media supplementation for 10 days demonstrates a 34.6% increase in bone volume and a 52.02% increase in bone mineral density (BMD) within the defect area, which are significantly higher than NS and a basal-media-control, as determined by microcomputed tomography. HPS-F-injected femur defects implanted on a chorioallantoic membrane (CAM) for 7 days exhibit an increase in bone mass of 123.5% and an increase in BMD of 215.2%, which are significantly higher than normal-serum-fibrin (NS-F) and no treatment. Histology reveals calcification, proteoglycan, and collagen fiber deposition in the defect area of HPS-F-treated femurs. Therefore, HPS-F may offer a promising and accessible therapeutic approach to accelerating bone regeneration by a single injection into the bone defect site. Full article
(This article belongs to the Special Issue Bone Tissue Engineering: Opportunities and Challenges)
12 pages, 553 KiB  
Article
Radiographical Diagnostic Evaluation of Mandibular Cortical Index Classification and Mandibular Cortical Width in Female Patients Prescribed Antiosteoporosis Medication: A Retrospective Cohort Study
by Keisuke Seki, Maki Nagasaki, Tona Yoshino, Mayuko Yano, Aki Kawamoto and Osamu Shimizu
Diagnostics 2024, 14(10), 1009; https://doi.org/10.3390/diagnostics14101009 (registering DOI) - 13 May 2024
Abstract
Osteoporosis is often detected late and becomes severe because of a lack of subjective symptoms. Digital panoramic radiography (DPR) has been reported to be useful for osteoporosis screening based on the morphological classification of the mandibular inferior cortex. The purpose of this study [...] Read more.
Osteoporosis is often detected late and becomes severe because of a lack of subjective symptoms. Digital panoramic radiography (DPR) has been reported to be useful for osteoporosis screening based on the morphological classification of the mandibular inferior cortex. The purpose of this study was to evaluate the sensitivity and specificity of the mandibular cortical index (MCI) in the diagnosis of osteoporosis in a group of patients who were and were not using antiosteoporosis medication (AOM). Three hundred and fifty female patients aged 40 years or older who had DPR imaging performed during a 6-year period from December 2015 to February 2022 met the selection criteria. Two examiners recorded mandibular cortical width and MCI from the images. These results were statistically examined together with the patients’ demographic data. Forty-nine patients were using AOM (13 nonbisphosphonate/denosumab and 36 bisphosphonate/denosumab). MCI type 3 was the most common in the AOM group. In the MCI classification, DPR imaging among the AOM group was more sensitive (0.95) than that of the control group. This method of estimating osteoporosis based on MCI classification using DPR images has high sensitivity, especially in patients using AOM, suggesting that this method is useful as a screening test. Full article
(This article belongs to the Section Medical Imaging and Theranostics)
11 pages, 616 KiB  
Article
Comparison of the Application of High-Resolution Inductively Coupled Plasma Mass Spectrometry (HR-ICP-MS) and Collision/Reaction Cell Technology of Inductively Coupled Plasma Mass Spectrometry (ICP-CCT-MS) in the Determination of Selenium in Coal-Bearing Strata
by Shumao Zhao, Rongkun Jia, Qiuchan Han, Niande Shang, Kaiyan Teng and Jiawei Feng
Minerals 2024, 14(5), 510; https://doi.org/10.3390/min14050510 (registering DOI) - 13 May 2024
Abstract
Selenium, a trace element of significant importance for human health and the environment, can be introduced into the environment through coal combustion. Accurate determination of selenium in coal and coal-bearing strata is essential for implementing effective management strategies and control measures to minimize [...] Read more.
Selenium, a trace element of significant importance for human health and the environment, can be introduced into the environment through coal combustion. Accurate determination of selenium in coal and coal-bearing strata is essential for implementing effective management strategies and control measures to minimize potential risks to human health and the environment. This study introduces an improved approach for the determination of 77Se in the medium resolution mode using HR-ICP-MS, effectively separating interference from doubly charged ions and enabling precise determination of selenium in coal-bearing strata. The relative errors of the standard reference samples obtained by HR-ICP-MS are between 0.65% and 6.33%, comparing to that of ICP-CCT-MS (1.58%–17.27%), prove the reliability of this method. Additionally, the X (bar)—S control charts obtained from HR-ICP-MS compared to ICP-CCT-MS demonstrate the superior stability of HR-ICP-MS in continuous determination. Consequently, though ICP-CCT-MS has better instrumental stability reflected through the internal standard recovery (ICP-CCT-MS:104.81%; HR-ICP-MS:80.54%), HR-ICP-MS is recommended as the preferred method for selenium determination in coal-bearing strata because of its high accuracy and good stability. Full article
(This article belongs to the Special Issue Selenium, Tellurium and Precious Metal Mineralogy)
22 pages, 1991 KiB  
Article
Significance of Sonic Velocities in Limestones and Dolostones: A Comprehensive Study Revealing Limited Impact of Mineralogy
by Ralf J. Weger, Gregor T. Baechle, Shouwen Shen and Gregor P. Eberli
Minerals 2024, 14(5), 509; https://doi.org/10.3390/min14050509 (registering DOI) - 13 May 2024
Abstract
Seismic reflection data and implicitly sonic velocity are undoubtedly the most important source of information for large-scale subsurface characterization. Yet, deriving reservoir and fluid flow properties from acoustic data is still challenging in carbonates, which display large acoustic velocity variations that contest many [...] Read more.
Seismic reflection data and implicitly sonic velocity are undoubtedly the most important source of information for large-scale subsurface characterization. Yet, deriving reservoir and fluid flow properties from acoustic data is still challenging in carbonates, which display large acoustic velocity variations that contest many of the conventional assumptions regarding wave propagation in porous media. In this comprehensive study on 370 carbonate samples (247 limestones and 123 dolomites), we re-evaluate the impact of mineral velocity on bulk rock acoustic properties of dolomite and limestone by assessing the link between sonic velocity and the rock’s pore geometry. We quantify pore size and pore network complexity using parameters from both digital image analysis (DIA) and the extended Biot theory (EBT). We then compare DIA and EBT parameters to assess the impact of pore network geometry versus mineral velocity on the acoustic velocity of carbonate rocks. We explore the usefulness of EBT parameter γk in improving permeability estimates. Published values of velocity indicate that dolomites exhibit higher velocities than limestones at any given porosity. Our laboratory measurements of acoustic velocity, however, reveal that both dolomites and limestones show extreme variations in sonic velocities where samples with compressional velocity of ~5000 m/s may range in porosity from 5% to 25% and samples with porosity of ~20% may range in velocity from ~4000 m/s to 5700 m/s. Through the quantitative assessment of the pore network in our samples we document that pore network geometry has much more impact on the acoustic velocity of carbonates than variations in mineralogy, in this case dolomite and calcite. Most of the dolostone samples studied are dominated by small pores, resulting in relatively low velocities for their given porosity, while limestones with similar velocity–porosity values often possess simpler pore networks with larger pores. This pore size difference offsets the faster velocity of dolomite. The extended Biot theory parameter γk, captures this variation in pore size and internal geometry and exhibits a strong correlation to specific surface. Moreover, γk captures the impact of internal pore geometry on acoustic velocity, providing the basis for challenging existing assumptions regarding the importance of mineral velocity. By quantifying internal geometry, γk can improve permeability estimates in reservoir characterization and enhance evaluations of producibility and injectability. With that, it has direct implications on general geophysics, hydrocarbon exploration, and CCS initiatives. Full article
17 pages, 1738 KiB  
Article
Study on SR-Crossbar RF MEMS Switch Matrix Port Configuration Scheme with Optimized Consistency
by Weiwei Zhou, Weixing Sheng and Binyun Yan
Sensors 2024, 24(10), 3099; https://doi.org/10.3390/s24103099 (registering DOI) - 13 May 2024
Abstract
The performance consistency of an RF MEMS switch matrix is a crucial metric that directly impacts its operational lifespan. An improved crossbar-based RF MEMS switch matrix topology, SR-Crossbar, was investigated in this article. An optimized port configuration scheme was proposed for the RF [...] Read more.
The performance consistency of an RF MEMS switch matrix is a crucial metric that directly impacts its operational lifespan. An improved crossbar-based RF MEMS switch matrix topology, SR-Crossbar, was investigated in this article. An optimized port configuration scheme was proposed for the RF MEMS switch matrix. Both the utilization probability of individual switch nodes and the path lengths in the switch matrix achieve their best consistency simultaneously under the proposed port configuration scheme. One significant advantage of this scheme lies in that it only adjusts the positions of the input and output ports, with the topology and individual switch nodes kept unchanged. This grants it a high level of generality and feasibility and also introduces an additional degree of freedom for optimizations. In this article, a universal utilization probability function of single nodes was constructed and an optimization objective function for the SR-Crossbar RF MEMS switch matrix was formulated, which provide a convenient approach to directly solving the optimized port configuration scheme for practical applications. Simulations to demonstrate the optimized dynamic and static consistencies were conducted. For an 8×8 SR-Crossbar switch matrix, the standard deviations of contact resistances of 128 units and losses of all 64 paths decreased from 1.00 and 0.42 to 0.51 and 0.23, respectively. These results aligned closely with theoretical calculations derived from the proposed model. Full article
(This article belongs to the Section Intelligent Sensors)
18 pages, 7353 KiB  
Article
Realistic Texture Mapping of 3D Medical Models Using RGBD Camera for Mixed Reality Applications
by Cosimo Aliani, Alberto Morelli, Eva Rossi, Sara Lombardi, Vincenzo Yuto Civale, Vittoria Sardini, Flavio Verdino and Leonardo Bocchi
Appl. Sci. 2024, 14(10), 4133; https://doi.org/10.3390/app14104133 (registering DOI) - 13 May 2024
Abstract
Augmented and mixed reality in the medical field is becoming increasingly important. The creation and visualization of digital models similar to reality could be a great help to increase the user experience during augmented or mixed reality activities like surgical planning and educational, [...] Read more.
Augmented and mixed reality in the medical field is becoming increasingly important. The creation and visualization of digital models similar to reality could be a great help to increase the user experience during augmented or mixed reality activities like surgical planning and educational, training and testing phases of medical students. This study introduces a technique for enhancing a 3D digital model reconstructed from cone-beam computed tomography images with its real coloured texture using an Intel D435 RGBD camera. This method is based on iteratively projecting the two models onto a 2D plane, identifying their contours and then minimizing the distance between them. Finally, the coloured digital models were displayed in mixed reality through a Microsoft HoloLens 2 and an application to interact with them using hand gestures was developed. The registration error between the two 3D models evaluated using 30,000 random points indicates values of: 1.1 ± 1.3 mm on the x-axis, 0.7 ± 0.8 mm on the y-axis, and 0.9 ± 1.2 mm on the z-axis. This result was achieved in three iterations, starting from an average registration error on the three axes of 1.4 mm to reach 0.9 mm. The heatmap created to visualize the spatial distribution of the error shows how it is uniformly distributed over the surface of the pointcloud obtained with the RGBD camera, except for some areas of the nose and ears where the registration error tends to increase. The obtained results indicate that the proposed methodology seems effective. In addition, since the used RGBD camera is inexpensive, future approaches based on the simultaneous use of multiple cameras could further improve the results. Finally, the augmented reality visualization of the obtained result is innovative and could provide support in all those cases where the visualization of three-dimensional medical models is necessary. Full article
18 pages, 7670 KiB  
Article
Development and Analysis of Six-Phase Synchronous Reluctance Motor for Increased Fault Tolerance Capabilities
by Cezary Jedryczka, Michal Mysinski and Wojciech Szelag
Energies 2024, 17(10), 2351; https://doi.org/10.3390/en17102351 (registering DOI) - 13 May 2024
Abstract
This paper contains research on the development of a fault-tolerant six-phase synchronous reluctance motor (SynRM) based on the stator adopted from a general-purpose three-phase induction motor. In the design and calculation process, an extended Clarke transformation was developed for a six-phase asymmetrical system. [...] Read more.
This paper contains research on the development of a fault-tolerant six-phase synchronous reluctance motor (SynRM) based on the stator adopted from a general-purpose three-phase induction motor. In the design and calculation process, an extended Clarke transformation was developed for a six-phase asymmetrical system. To verify the proposed design approach, a field–circuit model of electromagnetic phenomena in the studied motor was developed and used to study the motor performance. The increased torque value and reduction in torque ripples were confirmed by comparison to the classical three-phase SynRM design. To illustrate fault tolerance capabilities, the operation of the studied three- and six-phase synchronous reluctance motors under inverter-fault conditions was examined. The conducted analysis shows, among other things, that from the electromagnetic performance point of view, only the proposed six-phase machine is able to properly operate under inverter-fault conditions. The results of the winding design calculations, the performed simulations of six-phase motor operation, and the preliminary tests of the prototype motor are presented and discussed. Full article
(This article belongs to the Section F: Electrical Engineering)
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8 pages, 377 KiB  
Article
Impact and Occurrence of Herpesvirus and Aspergillosis Superinfection in Patients with Severe COVID-19 Pneumonia
by Antoinette D. Reichert, Júlia M. da Silva Voorham, Karin H. Groenewegen and Huub La van den Oever
COVID 2024, 4(5), 637-644; https://doi.org/10.3390/covid4050042 (registering DOI) - 13 May 2024
Abstract
Background: Pulmonary superinfections with Herpesviridae and Aspergillus spp. are common in severe coronavirus disease 2019 (COVID-19) pneumonia but their epidemiology and impact remain poorly understood. Methods: We conducted a retrospective observational study of 61 mechanically ventilated COVID-19 patients at Deventer Hospital’s ICU (2020–2021) [...] Read more.
Background: Pulmonary superinfections with Herpesviridae and Aspergillus spp. are common in severe coronavirus disease 2019 (COVID-19) pneumonia but their epidemiology and impact remain poorly understood. Methods: We conducted a retrospective observational study of 61 mechanically ventilated COVID-19 patients at Deventer Hospital’s ICU (2020–2021) who underwent bronchoalveolar lavage (BL) due to clinical deterioration. We analyzed blood and respiratory samples, treatment, and clinical outcomes. Results: Among 61 mechanically ventilated COVID-19 patients who underwent BL, 34 (55.7%) had superinfections, with 18 having COVID-19-associated pulmonary aspergillosis (CAPA), 7 having herpes simplex virus (HSV) infection, and 9 having both. Patients with HSV had later diagnoses (median 14 vs. 8 days, p = 0.014), longer mechanical ventilation (median 47 vs. 18.5 days, p = 0.015), and longer ICU stays (median 74 vs. 24 days, p = 0.021) compared to CAPA patients. At baseline, laboratory parameters and treatment (dexamethasone or tocilizumab) showed no significant association with superinfections. Mortality did not differ significantly among groups. Conclusion: In mechanically ventilated COVID-19 patients undergoing bronchoalveolar lavage, HSV reactivation occurred later in the course of illness and was associated with longer mechanical ventilation and ICU stays compared to CAPA. Baseline parameters did not predict superinfections. Full article
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28 pages, 13737 KiB  
Article
Emergence of Novel WEDEx-Kerberotic Cryptographic Framework to Strengthen the Cloud Data Security against Malicious Attacks
by Syeda Wajiha Zahra, Muhammad Nadeem, Ali Arshad, Saman Riaz, Waqas Ahmed, Muhammad Abu Bakr and Amerah Alabrah
Symmetry 2024, 16(5), 605; https://doi.org/10.3390/sym16050605 (registering DOI) - 13 May 2024
Abstract
Researchers have created cryptography algorithms that encrypt data using a public or private key to secure it from intruders. It is insufficient to protect the data by using such a key. No research article has identified an algorithm capable of protecting both the [...] Read more.
Researchers have created cryptography algorithms that encrypt data using a public or private key to secure it from intruders. It is insufficient to protect the data by using such a key. No research article has identified an algorithm capable of protecting both the data and the associated key, nor has any mechanism been developed to determine whether access to the data is permissible or impermissible based on the authentication of the key. This paper presents a WEDEx-Kerberotic Framework for data protection, in which a user-defined key is firstly converted to a cipher key using the “Secure Words on Joining Key (SWJK)” algorithm. Subsequently, a WEDEx-Kerberotic encryption mechanism is created to protect the data by encrypting it with the cipher key. The first reason for making the WEDEx-Kerberotic Framework is to convert the user-defined key into a key that has nothing to do with the original key, and the length of the cipher key is much shorter than the original key. The second reason is that each ciphertext and key value are interlinked. When an intruder utilizes the snatching mechanism to obtain data, the attacker obtains data or a key unrelated to the original data. No matter how efficient the algorithm is, an attacker cannot access the data when these methods and algorithms are used to protect it. Finally, the proposed algorithm is compared to the previous approaches to determine the uniqueness of the algorithm and assess its superiority to the previous algorithms. Full article
(This article belongs to the Section Computer)
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15 pages, 1807 KiB  
Article
Surface Bubbles Emergence as an Indicator for Optimal Concrete Compaction
by Hassan Ahmed and Jouni Punkki
Materials 2024, 17(10), 2306; https://doi.org/10.3390/ma17102306 (registering DOI) - 13 May 2024
Abstract
Compaction quality significantly influences the strength and durability of concrete in structures. Under-compacting can retain entrapped air, reducing strength, while over-compacting can lead to segregation, creating local variances in strength distribution and modulus of elasticity in the concrete structure. This study examines the [...] Read more.
Compaction quality significantly influences the strength and durability of concrete in structures. Under-compacting can retain entrapped air, reducing strength, while over-compacting can lead to segregation, creating local variances in strength distribution and modulus of elasticity in the concrete structure. This study examines the widely adopted concept that compaction is optimal when bubbles cease to emerge on the concrete surface. We recorded the surface activity of six comparable concrete specimens during the compaction process using a 4K video camera. Four specimens were compacted using a table vibrator and two with a poker vibrator. From the video frames, we isolated the bubbles for analysis, employing digital image processing techniques to distinguish newly risen bubbles per frame. It was found that the bubbles continuously rose to the surface in all specimens throughout the compaction process, suggesting a need for extended compaction, with some specimens showing a slow in the rate of the bubbles’ emergence. However, upon examining the segregation levels, it was discovered that all the specimens were segregated, some severely, despite the continued bubble emergence. These findings undermine the reliability of using bubble emergence as a principle to stop compaction and support the need for developing online measurement tools for evaluating compaction quality. Full article
(This article belongs to the Section Construction and Building Materials)
21 pages, 1257 KiB  
Article
An Edge Computing System with AMD Xilinx FPGA AI Customer Platform for Advanced Driver Assistance System
by Tsun-Kuang Chi, Tsung-Yi Chen, Yu-Chen Lin, Ting-Lan Lin, Jun-Ting Zhang, Cheng-Lin Lu, Shih-Lun Chen, Kuo-Chen Li and Patricia Angela R. Abu
Sensors 2024, 24(10), 3098; https://doi.org/10.3390/s24103098 (registering DOI) - 13 May 2024
Abstract
The convergence of edge computing systems with Field-Programmable Gate Array (FPGA) technology has shown considerable promise in enhancing real-time applications across various domains. This paper presents an innovative edge computing system design specifically tailored for pavement defect detection within the Advanced Driver-Assistance Systems [...] Read more.
The convergence of edge computing systems with Field-Programmable Gate Array (FPGA) technology has shown considerable promise in enhancing real-time applications across various domains. This paper presents an innovative edge computing system design specifically tailored for pavement defect detection within the Advanced Driver-Assistance Systems (ADASs) domain. The system seamlessly integrates the AMD Xilinx AI platform into a customized circuit configuration, capitalizing on its capabilities. Utilizing cameras as input sensors to capture road scenes, the system employs a Deep Learning Processing Unit (DPU) to execute the YOLOv3 model, enabling the identification of three distinct types of pavement defects with high accuracy and efficiency. Following defect detection, the system efficiently transmits detailed information about the type and location of detected defects via the Controller Area Network (CAN) interface. This integration of FPGA-based edge computing not only enhances the speed and accuracy of defect detection, but also facilitates real-time communication between the vehicle’s onboard controller and external systems. Moreover, the successful integration of the proposed system transforms ADAS into a sophisticated edge computing device, empowering the vehicle’s onboard controller to make informed decisions in real time. These decisions are aimed at enhancing the overall driving experience by improving safety and performance metrics. The synergy between edge computing and FPGA technology not only advances ADAS capabilities, but also paves the way for future innovations in automotive safety and assistance systems. Full article
(This article belongs to the Special Issue Sensors for Intelligent Vehicles and Autonomous Driving)
28 pages, 5233 KiB  
Article
Machine Learning Algorithms That Emulate Controllers Based on Particle Swarm Optimization—An Application to a Photobioreactor for Algal Growth
by Viorel Mînzu, Iulian Arama and Eugen Rusu
Processes 2024, 12(5), 991; https://doi.org/10.3390/pr12050991 (registering DOI) - 13 May 2024
Abstract
Particle Swarm Optimization (PSO) algorithms within control structures are a realistic approach; their task is often to predict the optimal control values working with a process model (PM). Owing to numerous numerical integrations of the PM, there is a big computational effort that [...] Read more.
Particle Swarm Optimization (PSO) algorithms within control structures are a realistic approach; their task is often to predict the optimal control values working with a process model (PM). Owing to numerous numerical integrations of the PM, there is a big computational effort that leads to a large controller execution time. The main motivation of this work is to decrease the computational effort and, consequently, the controller execution time. This paper proposes to replace the PSO predictor with a machine learning model that has “learned” the quasi-optimal behavior of the couple (PSO and PM); the training data are obtained through closed-loop simulations over the control horizon. The new controller should preserve the process’s quasi-optimal control. In identical conditions, the process evolutions must also be quasi-optimal. The multiple linear regression and the regression neural networks were considered the predicting models. This paper first proposes algorithms for collecting and aggregating data sets for the learning process. Algorithms for constructing the machine learning models and implementing the controllers and closed-loop simulations are also proposed. The simulations prove that the two machine learning predictors have learned the PSO predictor’s behavior, such that the process evolves almost identically. The resulting controllers’ execution time have decreased hundreds of times while keeping their optimality; the performance index has even slightly increased. Full article
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18 pages, 1370 KiB  
Article
A Sparse Recovery Algorithm for Suppressing Multiple Linear Frequency Modulation Interference in the Synthetic Aperture Radar Image Domain
by Guanqi Tong, Xingyu Lu, Jianchao Yang, Wenchao Yu, Hong Gu and Weimin Su
Sensors 2024, 24(10), 3095; https://doi.org/10.3390/s24103095 (registering DOI) - 13 May 2024
Abstract
In synthetic aperture radar (SAR) signal processing, compared with the raw data of level-0, level-1 SAR images are more readily accessible and available in larger quantities. However, an amount of level-1 images are affected by radio frequency interference (RFI), which typically originates from [...] Read more.
In synthetic aperture radar (SAR) signal processing, compared with the raw data of level-0, level-1 SAR images are more readily accessible and available in larger quantities. However, an amount of level-1 images are affected by radio frequency interference (RFI), which typically originates from Linear Frequency Modulation (LFM) signals emitted by ground-based radars. Existing research on interference suppression in level-1 data has primarily focused on two methods: transforming SAR images into simulated echo data for interference suppression, or focusing interference in the frequency domain and applying notching filters to reduce interference energy. However, these methods overlook the effective utilization of the interference parameters or are confined to suppressing only one type of LFM interference at a time. In certain SAR images, multiple types of LFM interference manifest bright radiation artifacts that exhibit varying lengths along the range direction while remaining constant in the azimuth direction. It is necessary to suppress multiple LFM interference on SAR images when original echo data are unavailable. This article proposes a joint sparse recovery algorithm for interference suppression in the SAR image domain. In the SAR image domain, two-dimensional LFM interference typically exhibits differences in parameters such as frequency modulation rate and pulse width in the range direction, while maintaining consistency in the azimuth direction. Based on this observation, this article constructs a series of focusing operators for LFM interference in SAR images. These operators enable the sparse representation of dispersed LFM interference. Subsequently, an optimization model is developed that can effectively suppress multi-LFM interference and reduce image loss with the assistance of a regularization term in the image domain. Simulation experiments conducted in various scenarios validate the superior performance of the proposed method. Full article
(This article belongs to the Section Radar Sensors)
9 pages, 390 KiB  
Article
I am Afraid I Will Not Be Able to Walk, That is What Worries Me—The Experience of Patients with Knee Osteoarthritis before Total Knee Arthroplasty: A Qualitative Study
by Umile Giuseppe Longo, Alessandra Corradini, Anna Marchetti, Chiara Di Sarno, Carlotta D’Angelo, Claudia Arias, Maria Grazia De Marinis, Alessandro de Sire and Vincenzo Denaro
J. Clin. Med. 2024, 13(10), 2878; https://doi.org/10.3390/jcm13102878 (registering DOI) - 13 May 2024
Abstract
Knee osteoarthritis is the most prevalent type of osteoarthritis. Patients frequently encounter pain triggered by movement that evolves into impaired joint function. Needing persistent rest or having night-time pain signifies advanced disease. Qualitative research is considered the most effective method for comprehending patients’ [...] Read more.
Knee osteoarthritis is the most prevalent type of osteoarthritis. Patients frequently encounter pain triggered by movement that evolves into impaired joint function. Needing persistent rest or having night-time pain signifies advanced disease. Qualitative research is considered the most effective method for comprehending patients’ needs and contexts. Methods: This study employed a qualitative research design, allowing the researchers to acquire insights into the patients’ beliefs and values, and the contextual factors influencing the formation and expression of these beliefs and values. Results: A cohort of nine patients awaiting total knee replacement (TKR) surgery was included and they were interviewed until data saturation was achieved. The results of the phenomenological analysis resulted in the identification of three themes: “The existence of pain impedes the capacity to participate in daily life activities”; “TKR induced fears and uncertainties regarding the progression of the disease”; “Severe nighttime pain compromising sleep quality”. Conclusions: This study analyzes the experiences of people awaiting TKR surgery, emphasizing the importance of addressing their unique needs to improve preoperative education and rehabilitation. In this way, patients’ recovery during the postoperative phase can be improved. Full article
(This article belongs to the Section Orthopedics)
23 pages, 513 KiB  
Communication
The Paradox of Alcohol and Food Affordability: Minimal Impact of Leading Beer and Cachaça Brands on Brazilian Household Income Amid Hazardous Drinking Patterns
by Ian C. C. Nóbrega, Rhennan V. L. Marques, Matheus A. Ferreira and Dirk W. Lachenmeier
Nutrients 2024, 16(10), 1469; https://doi.org/10.3390/nu16101469 (registering DOI) - 13 May 2024
Abstract
Alcohol consumption, associated with various cancers, mental disorders, and aggressive behavior, leads to three million deaths globally each year. In Brazil, the alcohol per capita consumption among drinkers aged 15 and over is 41.7 g of pure alcohol/day (~1 L beer/day), which falls [...] Read more.
Alcohol consumption, associated with various cancers, mental disorders, and aggressive behavior, leads to three million deaths globally each year. In Brazil, the alcohol per capita consumption among drinkers aged 15 and over is 41.7 g of pure alcohol/day (~1 L beer/day), which falls into the risky consumption category and exceeds the global average by almost 30%. An effective way to mitigate alcohol-related harm is to increase its retail price. This study assesses the costs of consuming leading brands of beer and sugarcane spirit cachaça (Brazil’s most popular alcoholic beverages) against the expenditure on staple foods. Data on food and alcoholic beverage prices were collected in João Pessoa, Brazil, for 2020 and 2021. The cost per gram of pure alcohol and food were considered to establish consumption patterns of 16.8 g/day (moderate), 41.7 g/day, and 83.4 g/day (heavy), distributed in three scenarios involving the beverages alone or combined (64% beer and 36% cachaça), and a balanced 2000 kcal/day staple diet. The study finds that all heavy consumption scenarios cost less or significantly less (cachaça alone) than a 2000 kcal/day staple diet, highlighting an urgent need for fiscal policies, such as a minimum unit pricing for alcohol, to address public health concerns. Full article
(This article belongs to the Special Issue Public Health, Nutritional Behavior and Nutritional Status)
18 pages, 1370 KiB  
Article
Accelerated Ballast Tank Corrosion Simulation Protocols: A Critical Assessment
by Remke Willemen, Kris De Baere, Rob Baetens, Maarten Van Rossum and Silvia Lenaerts
Materials 2024, 17(10), 2304; https://doi.org/10.3390/ma17102304 (registering DOI) - 13 May 2024
Abstract
 In the realm of accelerated testing within controlled laboratory settings, the fidelity of the service environment assumes paramount importance. It is imperative to replicate real-world conditions while compressing the testing duration to facilitate early evaluations, thereby optimizing time and cost efficiencies. Traditional [...] Read more.
 In the realm of accelerated testing within controlled laboratory settings, the fidelity of the service environment assumes paramount importance. It is imperative to replicate real-world conditions while compressing the testing duration to facilitate early evaluations, thereby optimizing time and cost efficiencies. Traditional immersion protocols, reflective solely of full ballast tank conditions, inadequately expedite the corrosion process representative of an average ballast tank environment. Through the integration of immersion with fog/dry conditions, aligning the test protocol more closely with the internal conditions of an average ballast tank, heightened rates of general corrosion are achieved. This augmentation yields an acceleration factor of 7.82 times the standard test duration, under the assumption of a general corrosion rate of 0.4 mm/year for uncoated ballast tank steel, with both sides exposed. Subsequently, the fog/dry test protocol, albeit only resembling the environment of an empty ballast tank, closely trails in terms of acceleration efficacy. The fog/dry test protocol offers cost-effectiveness and replicability compared to the AMACORT CIFD-01 protocol, making it a strong competitor despite the relatively close acceleration factor. Full article
(This article belongs to the Section Corrosion)
16 pages, 370 KiB  
Article
Lower Limb Motion Recognition with Improved SVM Based on Surface Electromyography
by Pengjia Tu, Junhuai Li and Huaijun Wang
Sensors 2024, 24(10), 3097; https://doi.org/10.3390/s24103097 (registering DOI) - 13 May 2024
Abstract
During robot-assisted rehabilitation, failure to recognize lower limb movement may efficiently limit the development of exoskeleton robots, especially for individuals with knee pathology. A major challenge encountered with surface electromyography (sEMG) signals generated by lower limb movements is variability between subjects, such as [...] Read more.
During robot-assisted rehabilitation, failure to recognize lower limb movement may efficiently limit the development of exoskeleton robots, especially for individuals with knee pathology. A major challenge encountered with surface electromyography (sEMG) signals generated by lower limb movements is variability between subjects, such as motion patterns and muscle structure. To this end, this paper proposes an sEMG-based lower limb motion recognition using an improved support vector machine (SVM). Firstly, non-negative matrix factorization (NMF) is leveraged to analyze muscle synergy for multi-channel sEMG signals. Secondly, the multi-nonlinear sEMG features are extracted, which reflect the complexity of muscle status change during various lower limb movements. The Fisher discriminant function method is utilized to perform feature selection and reduce feature dimension. Then, a hybrid genetic algorithm-particle swarm optimization (GA-PSO) method is leveraged to determine the best parameters for SVM. Finally, the experiments are carried out to distinguish 11 healthy and 11 knee pathological subjects by performing three different lower limb movements. Results demonstrate the effectiveness and feasibility of the proposed approach in three different lower limb movements with an average accuracy of 96.03% in healthy subjects and 93.65% in knee pathological subjects, respectively. Full article
(This article belongs to the Section Biosensors)
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