The development of e-textiles necessitates the creation of highly conductive inks that are compatible with precise inkjet printing, which remains a key challenge. This work presents an innovative, syringe-based method to optimize a novel bio-sourced silver ink for inkjet printing on textiles. We investigate the relationships between inks’ composition, rheological properties, and printing behavior, ultimately assessing the electrical performance of the fabricated circuits. Using Na–alginate and polyethylene glycol (PEG) as the suspension matrix, we demonstrate their viscosity depends on the component ratios. Rheological control of the silver nanoparticle-laden ink has become paramount for uniform printing on textiles. A specific formulation (3 wt.% AgNPs, 20 wt.% Na–alginate, 40 wt.% PEG, and 40 wt.% solvent) exhibits the optimal rheology, enabling the printing of 0.1 mm thick conductive lines with a low resistivity (8 × 10⁻³ Ω/cm). Our findings pave the way for designing eco-friendly ink formulations that are suitable for inkjet printing flexible antennas and other electronic circuits onto textiles, opening up exciting possibilities for the next generation of E-textiles. Full article

Introduction: Spinal intradural tumors account for 15% of all CNS tumors. Typical tumor entities include ependymomas, astrocytomas, meningiomas, and neurinomas. In cases of multiple affected segments, extensive approaches may be necessary to achieve the gold standard of complete tumor resection. Methods: We performed a bicentric, retrospective cohort study of all patients equal to or older than 14 years who underwent multi-segment surgical treatment for spinal intradural tumors between 2007 and 2023 with approaches longer than four segments without instrumentation. We assessed the surgical technique and the clinical outcome regarding signs of symptomatic spinal instability. Children were excluded from our cohort. Results: In total, we analyzed 33 patients with a median age of 44 years and interquartile range IQR of 30–56 years, including the following tumors: 21 ependymomas, one subependymoma–ependymoma mixed tumor, two meningiomas, two astrocytomas, and seven patients with other entities. The median length of the approach was five spinal segments with a range of 4–14 and with the foremost localization in the cervical or thoracic spine. Laminoplasty was the most chosen approach (72.2%). The median time to follow-up was 13 months IQR (4–56 months). Comparing pre- and post-surgery outcomes, 72.2% of the patients (n = 24) reported pain improvement after surgery. The median modified McCormick scores pre- and post surgery were equal to II IQR (I–II) and II IQR (I–III), respectively. Discussion: We achieved satisfying results with long-segment approaches. In general, patients reported pain improvement after surgery and received similar low modified McCormick scores pre- and post surgery and did not undergo secondary dorsal fixation. Thus, we conclude that intradural tumor resection via extensive approaches does not seem to impair long-term spinal stability in our cohort. Full article

Background: Chordomas pose a challenge in treatment due to their local invasiveness, high recurrence, and potential lethality. Despite being slow-growing and rarely metastasizing, these tumors often resist conventional chemotherapies (CTs) and radiotherapies (RTs), making surgical resection a crucial intervention. However, achieving radical resection for chordomas is seldom possible, presenting therapeutic challenges. The accurate diagnosis of these tumors is vital for their distinct prognoses, yet differentiation is hindered by overlapping radiological and histopathological features. Fortunately, recent molecular and genetic studies, including extracranial location analysis, offer valuable insights for precise diagnosis. This literature review delves into the genetic aberrations and molecular biology of chordomas, aiming to provide an overview of more successful therapeutic strategies. Methods: A systematic search was conducted across major medical databases (PubMed, Embase, and Cochrane Library) up to 28 January 2023. The search strategy utilized relevant Medical Subject Heading (MeSH) terms and keywords related to “chordomas”, “molecular biology”, “gene aberrations”, and “target therapies”. The studies included in this review consist of preclinical cell studies, case reports, case series, randomized controlled trials, non-randomized controlled trials, and cohort studies reporting on genetic and biological aberrations in chordomas. Results: Of the initial 297 articles identified, 40 articles were included in the article. Two tables highlighted clinical studies and ongoing clinical trials, encompassing 18 and 22 studies, respectively. The clinical studies involved 185 patients diagnosed with chordomas. The tumor sites were predominantly sacral (n = 8, 44.4%), followed by clivus (n = 7, 38.9%) and lumbar spine (n = 3, 16.7%). Primary treatments preceding targeted therapies included surgery (n = 10, 55.6%), RT (n = 9, 50.0%), and systemic treatments (n = 7, 38.9%). Various agents targeting specific molecular pathways were analyzed in the studies, such as imatinib (a tyrosine kinase inhibitor), erlotinib, and bevacizumab, which target EGFR/VEGFR. Common adverse events included fatigue (47.1%), skin reactions (32.4%), hypertension (23.5%), diarrhea (17.6%), and thyroid abnormalities (5.9%). Clinical outcomes were systematically assessed based on progression-free survival (PFS), overall survival (OS), and tumor response evaluated using RECIST or CHOI criteria. Notably, stable disease (SD) occurred in 58.1% of cases, and partial responses (PRs) were observed in 28.2% of patients, while 13.7% experienced disease progression (PD) despite targeted therapy. Among the 22 clinical trials included in the analysis, Phase II trials were the most prevalent (40.9%), followed by I-II trials (31.8%) and Phase I trials (27.3%). PD-1 inhibitors were the most frequently utilized, appearing in 50% of the trials, followed by PD-L1 inhibitors (36.4%), CTLA-4 inhibitors (22.7%), and mTOR inhibitors (13.6%). Conclusions: This systematic review provides an extensive overview of the state of targeted therapy for chordomas, highlighting their potential to stabilize the illness and enhance clinical outcomes. Full article

This study investigated the interfacial reactions between n-type Bi₂(Te,Se)₃ thermoelectric material, characterized by a highly-oriented (110) plane, and pure Sn and Sn-3.0Ag-0.5Cu (wt.%) solders, respectively. At 250 °C, the liquid-state Sn/Bi₂(Te,Se)₃ reactions resulted in the formation of both SnTe and BiTe phases, with Bi-rich particles dispersed within the SnTe phase. The growth of the SnTe phase exhibited diffusion-controlled parabolic behavior over time. In contrast, the growth rate was considerably slower compared to that observed with p-type (Bi,Sb)₂Te₃. Solid-state Sn/Bi₂(Te,Se)₃ reactions conducted between 160 °C and 200 °C exhibited similar interfacial microstructures. The SnTe phase remained the primary reaction product, embedded with tiny Bi-rich particles, revealing a diffusion-controlled growth. However, the BiTe layer had no significant growth. Further investigation into growth kinetics of intermetallic compounds and microstructural evolution was conducted to elucidate the reaction mechanism. The slower growth rates in Bi₂(Te,Se)₃, compared to the reactions with (Bi,Sb)₂Te₃, could be attributed to the strong suppression effect of Se on SnTe growth. Additionally, the interfacial reactions of Bi₂(Te,Se)₃ with Sn-3.0Ag-0.5Cu were also examined, showing similar growth behavior to those observed with Sn solder. Notably, compared with Ag, Cu tends to diffuse towards the interfacial reaction phases, resulting in a high Cu solubility within the SnTe phase. Full article

Fungi are eukaryotic organisms with relatively few pathogenic members dangerous for humans, usually acting as opportunistic infections. In the last decades, several life-threatening fungal infections have risen mostly associated with the worldwide extension of chronic diseases and immunosuppression. The available antifungal therapies cannot combat this challenge because the arsenal of compounds is scarce and displays low selective action, significant adverse effects, and increasing resistance. A growing isolation of outbreaks triggered by fungal species formerly considered innocuous is being recorded. From ancient times, natural substances harvested from plants have been applied to folk medicine and some of them recently emerged as promising antifungals. The most used are briefly revised herein. Combinations of chemotherapeutic drugs with natural products to obtain more efficient and gentle treatments are also revised. Nevertheless, considerable research work is still necessary before their clinical use can be generally accepted. Many natural products have a highly complex chemical composition, with the active principles still partially unknown. Here, we survey the field underlying lights and shadows of both groups. More studies involving clinical strains are necessary, but we illustrate this matter by discussing the potential clinical applications of combined carnosic acid plus propolis formulations. Full article

The bioprinting of high-concentrated collagen bioinks is a promising technology for tissue engineering and regenerative medicine. Collagen is a widely used biomaterial for bioprinting because of its natural abundance in the extracellular matrix of many tissues and its biocompatibility. High-concentrated collagen hydrogels have shown great potential in tissue engineering due to their favorable mechanical and structural properties. However, achieving high cell proliferation rates within these hydrogels remains a challenge. In static cultivation, the volume of the culture medium is changed once every few days. Thus, perfect perfusion is not achieved due to the relative increase in metabolic concentration and no medium flow. Therefore, in our work, we developed a culture system in which printed collagen bioinks (collagen concentration in hydrogels of 20 and 30 mg/mL with a final concentration of 10 and 15 mg/mL in bioink) where samples flow freely in the culture medium, thus enhancing the elimination of nutrients and metabolites of cells. Cell viability, morphology, and metabolic activity (MTT tests) were analyzed on collagen hydrogels with a collagen concentration of 20 and 30 mg/mL in static culture groups without medium exchange and with active medium perfusion; the influence of pure growth culture medium and smooth muscle cells differentiation medium was next investigated. Collagen isolated from porcine skins was used; every batch was titrated to optimize the pH of the resulting collagen to minimize the difference in production batches and, therefore, the results. Active medium perfusion significantly improved cell viability and activity in the high-concentrated gel, which, to date, is the most limiting factor for using these hydrogels. In addition, based on SEM images and geometry analysis, the cells remodel collagen material to their extracellular matrix. Full article

Over the past decade, microbiome research has significantly expanded in both scope and volume, leading to the development of new models and treatments targeting the gut–brain axis to mitigate the effects of various disorders. Related research suggests that interventions during the critical period from birth to three years old may yield the greatest benefits. Investigating the substantial link between the gut and brain during this crucial developmental phase raises fundamental issues about the role of microorganisms in human health and brain development. This underscores the importance of focusing on the prevention rather than the treatment of neurodevelopmental and neuropsychiatric disorders. The present review examines the gut microbiota from birth to age 3, with a particular focus on its potential relationship with neurodevelopment. This review emphasizes the immunological mechanisms underlying this relationship. Additionally, the study investigates the impact of the microbiome on cognitive development and neurobehavioral issues such as anxiety and autism. Importantly, it highlights the need to integrate mechanistic studies of animal models with epidemiological research across diverse cultures to better understand the role of a healthy microbiome in early life and the implications of dysbiosis. Furthermore, this review summarizes factors contributing to the transmission of gut microbiome-targeted therapies and their effects on neurodevelopment. Recent studies on environmental toxins known to impact neurodevelopment are also reviewed, exploring whether the microbiota may mitigate or modulate these effects. Full article

Accurately detecting defects while reconstructing a high-quality normal background in surface defect detection using unsupervised methods remains a significant challenge. This study proposes an unsupervised method that effectively addresses this challenge by achieving both accurate defect detection and a high-quality normal background reconstruction without noise. We propose an adaptive weighted structural similarity (AW-SSIM) loss for focused feature learning. AW-SSIM improves structural similarity (SSIM) loss by assigning different weights to its sub-functions of luminance, contrast, and structure based on their relative importance for a specific training sample. Moreover, it dynamically adjusts the Gaussian window’s standard deviation ($\sigma$) during loss calculation to balance noise reduction and detail preservation. An artificial defect generation algorithm (ADGA) is proposed to generate an artificial defect closely resembling real ones. We use a two-stage training strategy. In the first stage, the model trains only on normal samples using AW-SSIM loss, allowing it to learn robust representations of normal features. In the second stage of training, the weights obtained from the first stage are used to train the model on both normal and artificially defective training samples. Additionally, the second stage employs a combined learned Perceptual Image Patch Similarity (LPIPS) and AW-SSIM loss. The combined loss helps the model in achieving high-quality normal background reconstruction while maintaining accurate defect detection. Extensive experimental results demonstrate that our proposed method achieves a state-of-the-art defect detection accuracy. The proposed method achieved an average area under the receiver operating characteristic curve (AuROC) of 97.69% on six samples from the MVTec anomaly detection dataset. Full article

Film bulk acoustic-wave resonators (FBARs) are widely utilized in the field of radio frequency (RF) filters due to their excellent performance, such as high operation frequency and high quality. In this paper, we present the design, fabrication, and characterization of an FBAR filter for the 3.0 GHz–3.2 GHz S-band. Using a scandium-doped aluminum nitride (Sc_0.2Al_0.8N) film, the filter is designed through a combined acoustic–electromagnetic simulation method, and the FBAR and filter are fabricated using an eight-step lithographic process. The measured FBAR presents an effective electromechanical coupling coefficient ($k_{eff}^2$) value up to 13.3%, and the measured filter demonstrates a −3 dB bandwidth of 115 MHz (from 3.013 GHz to 3.128 GHz), a low insertion loss of −2.4 dB, and good out-of-band rejection of −30 dB. The measured 1 dB compression point of the fabricated filter is 30.5 dBm, and the first series resonator burns out first as the input power increases. This work paves the way for research on high-power RF filters in mobile communication. Full article

Studies on the sediments of lakes with varying trophic status are of particular importance when considering changes in the natural environment. In this study, our objective was to examine subfossil remains of Cladocera species and the relationship between the sedimental Cladocera assemblages and geochemical variables during 11 years of sediment records from northern Hungarian lakes. To achieve this, we compared sedimental cladoceran communities and the geochemistry of the sediment layers among lakes. Among the studied lakes, one was an intermittent lake (KMT: the Kis-Morotva Lake) which dried out in 2012 but was subsequently naturally refilled in 2013 by groundwater affected by the high-water level of the River Tisza. The other type consisted of permanent lakes (SZA: the Szabolcs oxbow lake, TI: the Timár Morotva Lake) that never dried out. The results of the beta diversity analysis show that the deposition of Cladocera communities was similar among the sediment layers of lakes, while the abundance differences contributed significantly to replacement. Subsequently, core sediment samples of the three lakes were compared based on the remains of Cladocera communities and geochemical variables using Adonis (PERMANOVA). The core sediment samples indicate variations in Cladocera communities alongside disparities in geochemical variables across the same lakes. In conclusion, the significance of sediment cores containing the remains of the Cladocera community has grown significantly in the reconstruction of historical ecological and climatic changes. Full article

Overexploitation in wild-capture fisheries is a principal driver of marine biodiversity loss. Currently, efforts are underway to improve the representation of marine damage indicators in Life Cycle Impact Assessment (LCIA) methods. The recently operationalised fisheries impact pathway has introduced fishing impacts on the marine system into the LCIA framework, and the current work seeks to further develop this complex pathway. In total, 5000+ Characterisation Factors for exploited marine organisms have been re-computed with updated fisheries production data (2018), exploring temporal effects on dynamic, biotic resource impacts. An estimation of discarded unwanted by-catch is incorporated into the characterisation. Regional to global scaling factors are tested for the representation of species-specific vulnerability. The temporal and spatial variations in impacts reflect the dynamic nature of real-world fisheries trends, global average impacts increased by 41% (2015–2018). Discarding as an additive, regional estimate increases impacts, most notably for lower impacted stocks. The retention of species-specific detail relating to species distributions is of particular relevance to fisheries when computing global-scale impacts. Updating CFs improves the relevance of the fisheries impact assessment, and continued periodic re-computation is recommended to maintain relevance with real-world trends. Data availability remains a challenge to large-scale marine impact assessment and the continued development of this emergent impact pathway is expected. Full article

The use of medicinal substances in nanosized forms (nanoforms, nanoparticles) allows the therapeutic effectiveness of pharmaceutical preparations to be increased due to several factors: (1) the high specific surface area of nanomaterials, and (2) the high concentration of surface-active centers interacting with biological objects. In the case of drug nanoforms, even low concentrations of a bioactive substance can have a significant therapeutic effect on living organisms. These effects allow pharmacists to use lower doses of active components, consequently lowering the toxic side effects of pharmaceutical nanoform preparations. It is known that many drug substances that are currently in development are poorly soluble in water, so they have insufficient bioavailability. Converting them into nanoforms will increase their rate of dissolution, and the increased saturation solubility of drug nanocrystals also makes a significant contribution to their high therapeutic efficiency. Some physical and chemical methods can contribute to the formation of both pure drug nanoparticles and their ligand or of polymer-covered nanoforms, which are characterized by higher stability. This review describes the most commonly used methods for the preparation of nanoforms (nanoparticles) of different medicinal substances, paying close attention to modern supercritical and cryogenic technologies and the advantages and disadvantages of the described methods and techniques; moreover, the improvements in the physico-chemical and biomedical properties of the obtained medicinal nanoforms are also discussed. Full article

The endoscopic contralateral transmaxillary (CTM) approach has been proposed as a potential route to widen the corridor posterolateral to the internal carotid artery (ICA). In this study, we first refined the surgical technique of a combined multiportal endoscopic endonasal transclival (EETC) and CTM approach to the petrous apex (PA) and petroclival synchondrosis (PCS) in the dissection laboratory, and then validated its applications in a preliminary surgical series. The combined EETC and CTM approach was performed on three cadaver specimens based on four surgical steps: (1) the nasal, (2) the clival, (3) the maxillary and (4) the petrosal phases. The CTM provided a “head-on trajectory” to the PA and PCS and a short distance to the surgical field considerably furthering surgical maneuverability. The best operative set-up was achieved by introducing angled optics via the endonasal route and operative instruments via the transmaxillary corridor exploiting the advantages of a non-coaxial multiportal surgery. Clinical applications of the combined EETC and CTM approach were reported in three cases, a clival chordoma and two giant pituitary adenomas. The present translational study explores the safety and feasibility of a combined multiportal EETC and CTM approach to access the petroclival region though different corridors. Full article

The current study reports on the impact of a series of functional alkoxysilanes on the wettability and structure of a well-established silicon/zirconium hybrid anticorrosion sol–gel coating. The selected functional alkoxysilanes comprise tetra ethylorthosilicate (TEOS), 3-glycidyloxypropyltrimethoxysilane (GPTMS), 3-aminopropyltriethoxysilane (APTES) and vinyltriethoxysilane (VTES) and are incorporated at various concentrations (1, 5, 10 and 20%) within the silicon/zirconium sol–gel material. The prepared materials are successfully processed as coatings and cured at different temperatures in the range of 100–150 °C. The characterisation of the structures and surfaces is performed by dynamic light scattering (DLS), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), silicon nuclear magnetic resonance spectroscopy (²⁹Si-NMR), atomic force microscopy (AFM) and static water contact angle (WCA). Structural characterisations (DLS, FTIR,²⁹Si-NMR) show that the functional alkoxysilanes effectively bind at the surface of the reference sol–gel material, resulting in the formation of functional core–shell nanoparticles. WCA results show that the hydrophobic properties of all materials decrease with curing temperature, and AFM analysis demonstrated that this behaviour is associated with a decrease in roughness. The physico-chemical processes taking place are critically assigned and discussed. Full article

This research aimed to explore the healing impacts of Melittin treatment on gastrocnemius muscle wasting caused by immobilization with a cast in rabbits. Twenty-four rabbits were randomly allocated to four groups. The procedures included different injections: 0.2 mL of normal saline to Group 1 (G1-NS); 4 μg/kg of Melittin to Group 2 (G2-4 μg/kg Melittin); 20 μg/kg of Melittin to Group 3 (G3-20 μg/kg Melittin); and 100 μg/kg of Melittin to Group 4 (G4-100 μg/kg Melittin). Ultrasound was used to guide the injections into the rabbits’ atrophied calf muscles following two weeks of immobilization via casting. Clinical measurements, including the length of the calf, the compound muscle action potential (CMAP) of the tibial nerve, and the gastrocnemius muscle thickness, were assessed. Additionally, cross-sectional slices of gastrocnemius muscle fibers were examined, and immunohistochemistry and Western blot analyses were performed following two weeks of therapy. The mean regenerative changes, as indicated by clinical parameters, in Group 4 were significantly more pronounced than in the other groups (p < 0.05). Furthermore, the cross-sectional area of the gastrocnemius muscle fibers and immunohistochemical indicators in Group 4 exceeded those in the remaining groups (p < 0.05). Western blot analysis also showed a more significant presence of anti-inflammatory and angiogenic cytokines in Group 4 compared to the others (p < 0.05). Melittin therapy at a higher dosage can more efficiently activate regeneration in atrophied gastrocnemius muscle compared to lower doses of Melittin or normal saline. Full article

Herein, a catalytic amplification enhanced dual-signal immunochromatographic assay (ICA) based on Pt nanoparticles (Pt NPs) modified with Ti₃C₂Tx MXene (Ti₃C₂Tx@Pt) was first developed for chloramphenicol (CAP) in animal-derived foods. Due to the large specific surface area and abundant active sites of Ti₃C₂Tx@Pt, they can be loaded with hundreds of Pt NPs to enhance their catalytic activity, resulting in a significant increase in the detection sensitivity; the sensitivity was up to 50-fold more sensitive than the reported ICA for CAP. The LODs of the developed method for milk/chicken/fish were 0.01 μg/kg, the LOQs were 0.03 μg/kg and the recovery rates were 80.5–117.0%, 87.2–118.1% and 92.7–117.9%, with corresponding variations ranging from 3.1 to 9.6%, 6.0 to 12.7% and 6.0 to 13.6%, respectively. The linear range was 0.0125–1.0 μg/kg. The results of the LC-MS/MS confirmation test on 30 real samples had a good correlation with that of our established method (R² > 0.98), indicating the practical reliability of the established method. The above results indicated that an ICA based on the Ti₃C₂Tx@Pt nanozyme has excellent potential as a food safety detection tool. Full article

Predicting sound sources in reverberant environments is a challenging task because reverberation causes reflection and scattering of sound waves, making it difficult to accurately determine the position of the sound source. Due to the characteristics of overcoming multipath effects and adaptive focusing of the time reversal technology, this paper focuses on the application of the time reversal operator decomposition method for sound source localization in reverberant environments and proposes the image-source time reversal multiple signals classification (ISTR-MUSIC) method. Firstly, the time reversal operator is derived, followed by the proposal of a subspace method to achieve sound source localization. Meanwhile, the use of the image-source method is proposed to calculate and construct the transfer matrix. To validate the effectiveness of the proposed method, simulations and real-data experiments were performed. In the simulation experiments, the performance of the proposed method under different array element numbers, signal-to-noise ratios, reverberation times, frequencies, and numbers of sound sources were studied and analyzed. A comparison was also made with the traditional time reversal method and the MUSIC algorithm. The experiment was conducted in a reverberation chamber. Simulation and experimental results show that the proposed method has good localization performance and robustness in reverberant environments. Full article

The remote detection of hydrothermally altered grounds in geothermal exploration demands datasets capable of reliably detecting key outcrops with fine spatial resolution. While optical thermal or radar-based datasets have resolution limitations, airborne LiDAR offers point-based detection through its LiDAR return intensity (LRI) values, serving as a proxy for surface reflectivity. Despite this potential, few studies have explored LRI value variations in the context of hydrothermal alteration and their utility in distinguishing altered from unaltered rocks. Although the link between alteration degree and LRI values has been established under laboratory conditions, this relationship has yet to be demonstrated in airborne data. This study investigates the applicability of laboratory results to airborne LRI data for alteration detection. Utilising LRI data from an airborne LiDAR point cloud (wavelength 1064 nm, density 12 points per square metre) acquired over a prospective geothermal area in Bajawa, Indonesia, where rock sampling for a related laboratory study took place, we compare the airborne LRI values within each ground sampling area of a 3 m radius (due to hand-held GPS uncertainty) with laboratory LRI values of corresponding rock samples. Our findings reveal distinguishable differences between strongly altered and unaltered samples, with LRI discrepancies of approximately ~28 for airborne data and ~12 for laboratory data. Furthermore, the relative trends of airborne and laboratory-based LRI data concerning alteration degree exhibit striking similarity. These consistent results for alteration degree in laboratory and airborne data mark a significant step towards LRI-based alteration mapping from airborne platforms. Full article

Everyday activity incurs carbon footprints, which are classified as personal, production, organizational and national, and may be assessed by input–output analysis (IOA), life-cycle assessment (LCA), or the combination of LCA and IOA methods. Notwithstanding international standards, like ISO 14064 and Publicly Available Specification (PAS) released for standardization, carbon footprint results can vary and sometimes lack consistency that due to variations in data sources, crossover boundary definitions, and operational boundaries for indirect emissions. The novelty of this study is the direct utilization of condensed water in an existing cooling water system, without the need for prior wastewater treatment, as typically required for greywater. The lack of practical case studies exploring the water–energy nexus in the context of reclaiming condensed water for evaporative cooling tower systems makes this research particularly significant. This highlights that condensed water can be a straightforward and cost-effective solution for both water conservation and energy savings. This case study highlights the benefits of reclaiming condensed water as supplementary cooling water, which proved effective in water quality treatment and dilution augmentation, considering that a higher cycle of concentration (CoC) was achieved, leading to reduced bleed-off that resulted in a water saving of 44% for make-up and 80% for bleed-off water, and energy savings from 6.9% to 13.1% per degree Celsius of condensing refrigerant temperature (CRT). The analytical assessment revealed that reclaiming condensed water is a promising answer for green building and is a by-product of condensation without extra power demands, avoiding the generation of an increased carbon footprint and exacerbation of greenhouse gas (GHG) emissions from freshwater resource extraction, and for the production of energy-efficient devices or substitutions. By eliminating the need for wastewater treatment, this research enhances the practicality and feasibility of direct use of condensed water in various applications. This approach not only promotes sustainability by conserving water and energy but also renews interest among proponents of green building practices. It has the potential to accelerate the adoption of this method and integrate it into green building designs. Full article

In this systematic literature review, we delve into the realm of intention recognition within the context of digital forensics and cybercrime. The rise of cybercrime has become a major concern for individuals, organizations, and governments worldwide. Digital forensics is a field that deals with the investigation and analysis of digital evidence in order to identify, preserve, and analyze information that can be used as evidence in a court of law. Intention recognition is a subfield of artificial intelligence that deals with the identification of agents’ intentions based on their actions and change of states. In the context of cybercrime, intention recognition can be used to identify the intentions of cybercriminals and even to predict their future actions. Employing a PRISMA systematic review approach, we curated research articles from reputable journals and categorized them into three distinct modeling approaches: logic-based, classical machine learning-based, and deep learning-based. Notably, intention recognition has transcended its historical confinement to network security, now addressing critical challenges across various subdomains, including social engineering attacks, artificial intelligence black box vulnerabilities, and physical security. While deep learning emerges as the dominant paradigm, its inherent lack of transparency poses a challenge in the digital forensics landscape. However, it is imperative that models developed for digital forensics possess intrinsic attributes of explainability and logical coherence, thereby fostering judicial confidence, mitigating biases, and upholding accountability for their determinations. To this end, we advocate for hybrid solutions that blend explainability, reasonableness, efficiency, and accuracy. Furthermore, we propose the creation of a taxonomy to precisely define intention recognition, paving the way for future advancements in this pivotal field. Full article

Pediatric multiple sclerosis (MS) and neuromyelitis optica (NMO) are rare acquired demyelinating syndrome with limited epidemiological data available, particularly in non-Western setting. This study aimed to demonstrate the epidemiology of pediatric MS and NMO in South Korea and to analyze of healthcare utilization and economic burden associated with these conditions. Using a nationwide population-based database from the Korean Health Insurance Review and Assessment Service database, we identified pediatric cases (age < 20 years) of MS and NMO from 2016 to 2020. We analyzed incidence, prevalence, healthcare utilization and medical costs. The study found low age-standardized incidence and prevalence rates for pediatric MS and NMO in South Korea. There was a marked disparity in healthcare utilization between urban and rural areas. Most healthcare interactions occurred in tertiary hospitals in urban settings, particularly in Seoul. The study also highlighted the substantial economic burden associated with the management of rare diseases, with annual variability in medical costs. Pediatric MS and NMO are extremely rare in South Korea, with significant regional disparity in healthcare utilization. The findings emphasize the need for targeted healthcare policies to improve access and reduce disparities, particularly for chronic and rare diseases requiring specialized care. Full article

An arbitrary Lagrangian-Eulerian lattice Boltzmann flux solver (ALE-LBFS) coupled with the mode superposition method is proposed in this work and applied to study two- and three-dimensional flutter phenomenon on dynamic unstructured meshes. The ALE-LBFS is applied to predict the flow field by using the vertex-centered finite volume method with an implicit dual time-stepping method. The convective fluxes are evaluated by using lattice Boltzmann solutions of the non-free D1Q4 lattice model and the viscous fluxes are obtained directly. Additional fluxes due to mesh motion are calculated directly by using local conservative variables and mesh velocity. The mode superposition method is used to solve for the dynamic response of solid structures. The exchange of aerodynamic forces and structural motions is achieved through interpolation with the radial basis function. The flow solver and the structural solver are tightly coupled so that the restriction on the physical time step can be removed. In addition, geometric conservation law (GCL) is also applied to guarantee conservation laws. The proposed method is tested through a series of simulations about moving boundaries and fluid–structure interaction problems in 2D and 3D. The present results show good consistency against the experiments and numerical simulations obtained from the literature. It is also shown that the proposed method not only can effectively predict the flutter boundaries in both 2D and 3D cases but can also accurately capture the transonic dip phenomenon. The tight coupling of the ALE-LBFS and the mode superposition method presents an effective and powerful tool for flutter prediction and can be applied to many essential aeronautical problems. Full article