Background/Objective: No guidelines indicate surgical risk factors for the elderly because of the lack of data from general neurosurgeons. To better understand the management of surgical risk in elderly patients with meningiomas based on a national database in Japan. Methods: Results of surgically treated meningiomas were explored in 8138 patients registered in the Diagnosis Procedure Combination database in Japan during 2010–2015. Age (<65, 65–74, and ≥75 years), sex, Barthel index (BI), medical history, tumor location, oral medication prescriptions on admission, and stroke complications were evaluated. Multivariate logistic regression analysis identified risk factors for stroke complications, BI deterioration between admission and discharge, and in-hospital mortality. Results: Advanced age was the prominent risk factor for BI deterioration (odds ratio: 3.26; 95% confidence interval: 2.69–3.95) but not for in-hospital mortality. Lower BI (60–80) on admission increased the risk of BI deterioration in all age groups; however, BI < 60 demonstrated a significant inverse risk (0.47; 0.32–0.69) in the elderly (≥75 years). Location (falx, parasagittal, and deep) and anticoagulants were not significant risk factors for BI deterioration in patients aged ≥ 75 years, despite being significant risk factors in patients aged <65 and/or 65–74 years. Conclusions: Although advanced age could lead to postoperative functional decline at discharge, it was not sufficiently significant enough to be associated with in-hospital mortality. Because of the possibility of recovery even in elderly patients with severe disabilities, appropriate surgical selection and optimal management may lead to favorable functional outcomes in elderly patients with meningiomas. Full article

Gastric cancer is the fifth most common cancer and the fourth cause of global cancer mortality. The identification of new biomarkers and drug targets is crucial to allow the better prognosis and treatment of patients. The mitotic spindle positioning (MISP) protein has the function of correcting mitotic spindle positioning and centrosome clustering and has been implicated in the cytokinesis and migration of cancer cells. The goal of this work was to evaluate the expression and clinical relevance of MISP in gastric cancer. MISP expression was evaluated by immunohistochemistry in a single hospital series (n = 286) of gastric adenocarcinomas and compared with normal gastric mucosa and intestinal metaplasia, a preneoplastic lesion. MISP was detected on the membrane in 83% of the cases, being overexpressed in gastric cancer compared to normal gastric mucosa (n = 10). Its expression was negatively associated with diffuse and poorly cohesive types. On the other hand, it was strongly expressed in intestinal metaplasia where it was associated with MUC2 and CDX2 expression. Furthermore, when we silenced MISP in vitro, a significant decrease in the viability of gastric carcinoma cells was observed. In conclusion, MISP is overexpressed in gastric cancer, being associated with an intestinal phenotype in gastric carcinogenesis and having a role in cellular proliferation. Full article

Hypertensive diseases of pregnancy (HDPs) represent a global clinical challenge, affecting 5–10% of women and leading to complications for both maternal well-being and fetal development. At the heart of these complications is endothelial dysfunction, with oxidative stress emerging as a pivotal causative factor. The reduction in nitric oxide (NO) bioavailability is a vital indicator of this dysfunction, culminating in blood pressure dysregulation. In the therapeutic context, although antihypertensive medications are commonly used, they come with inherent concerns related to maternal–fetal safety, and a percentage of women do not respond to these therapies. Therefore, alternative strategies that directly address the pathophysiology of HDPs are required. This article focuses on the potential of the nitrate-nitrite-NO pathway, abundantly present in dark leafy greens and beetroot, as an alternative approach to treating HDPs. The objective of this review is to discuss the prospective antioxidant role of nitrate. We hope our discussion paves the way for using nitrate to improve endothelial dysfunction and control oxidative stress, offering a potential therapy for managing HDPs. Full article

The grouting quality of prestressed pipelines directly affects the safety and durability of prestressed reinforced concrete bridge structures, attracting wide attention from the engineering community. Based on the principles of the scattering wave method, this paper designs and manufactures a large-scale model to simulate the actual construction testing environment. Several sets of design defects with significantly distributed spans in the prestressing ducts were pre-set, and the Engineering Geophysical Instrument System–Pipeline Grouting Profile (EGS-PGP) equipment developed was used to detect the grouting quality of the prestressed pipelines under different conditions, obtaining the frequency attenuation values at defect locations. The study shows that stability of the peak frequency throughout the test can indicate compact grouting, while a large fluctuation in the peak frequency range with no regular changes can indicate non-compact grouting; a sudden increase or decrease in peak frequency can effectively indicate the location of grouting defects along the pipeline. The number of sudden changes in frequency can indicate the number of gaps inside the pipeline. The chirp signal, compared to the hammer impact signal, shows greater stability and engineering application value in detecting defects using the scatter wave method. This study provides technical support for the detection of grouting quality in prestressed pipelines based on chirp signals. Full article

The negatively charged extracellular matrix plays a vital role in intervertebral disc tissues, providing specific cues for cell maintenance and tissue hydration. Unfortunately, suitable biomimetics for intervertebral disc regeneration are lacking. Here, sulfated alginate was investigated as a 3D culture material due to its similarity to the charged matrix of the intervertebral disc. Precursor solutions of standard alginate, or alginate with 0.1% or 0.2% degrees of sulfation, were mixed with primary human nucleus pulposus cells, cast, and cultured for 14 days. A 0.2% degree of sulfation resulted in significantly decreased cell density and viability after 7 days of culture. Furthermore, a sulfation-dependent decrease in DNA content and metabolic activity was evident after 14 days. Interestingly, no significant differences in cell density and viability were observed between surface and core regions for sulfated alginate, unlike in standard alginate, where the cell number was significantly higher in the core than in the surface region. Due to low cell numbers, phenotypic evaluation was not achieved in sulfated alginate biomaterial. Overall, standard alginate supported human NP cell growth and viability superior to sulfated alginate; however, future research on phenotypic properties is required to decipher the biological properties of sulfated alginate in intervertebral disc cells. Full article

This study examines the catalytic activity of NiFeCoO_x catalysts for anion exchange membrane (AEM) water electrolysis. The catalysts were synthesized with a Ni to Co ratio of 2:1 and Fe content ranges from 2.5 to 12.5 wt%. The catalysts were characterized using scanning electron microscopy (SEM) and X-ray diffraction (XRD) techniques. The catalytic activity of the NiFeCoO_x catalysts was evaluated through linear sweep voltammetry (LSV) and chronoamperometry (CA) experiments for the oxygen evolution reaction (OER). The catalyst with 5% Fe content exhibited the highest catalytic activity, achieving an overpotential of 228 mV at a current density of 10 mA cm⁻². Long-term catalyst testing for the OER at 50 mA cm⁻² showed stable electrolysis operation for 100 h. The catalyst was further analyzed in an AEM water electrolyzer in a single-cell test, and the NiFeCoO_x catalyst with 5% Fe at the anode demonstrated the highest current densities of 1516 mA cm⁻² and 1620 mA cm⁻² at 55 °C and 70 °C at 2.1 V. The maximum current density of 1880 mA cm⁻² was achieved at 2.2 V and 70 °C. The Nyquist plot analysis of electrolysis at 55 °C showed that the NiFeCoO_x catalyst with 5% Fe had lower activation resistance compared with the other Fe loadings, indicating enhanced performance. The durability test was performed for 8 h, showing stable AEM water electrolysis with minimum degradation. An overall cell efficiency of 70.5% was achieved for the operation carried out at a higher current density of 0.8 A cm⁻². Full article

The objective of this study was to evaluate the effects of giant cactus harvest time and the inclusion of pigeon pea hay in improving the ensiling process and the nutritional composition of cactus silage. In total, 40 polyvinyl chloride-PVC mini-silos (10 × 40 cm) were used. Mini-silos were distributed in a 2 × 5 factorial scheme, referent to 2 harvest times (18 and 24 months) and 5 levels (0, 10%, 20%, 30%, and 40%) of pigeon pea hay inclusion in a randomized design. Effluent losses (p < 0.001) showed a negative linear effect as the inclusion of pigeon pea hay increased. Gas losses (p < 0.001), dry matter (DM) recovery (p < 0.001), and pH (p < 0.001) revealed the interactive effects between the pigeon pea hay inclusion and the harvest time. The DM content was higher in the giant cactus harvested at 24 months. The difference in nutritional composition promoted by the harvest time did not affect the silage quality. The gradual inclusion of pigeon pea hay improved the fermentative and bromatological characteristics of giant cactus silage. It is important to highlight that the inclusion of pigeon pea hay contributed to the increase in pH without affecting the necessary acidity for ideal conservation. Full article

Adolescent idiopathic scoliosis (AIS) is a three-dimensional structural deformity of the spine that affects 2–3% of adolescents under the age of 16. AIS etiopathogenesis is not completely understood; however, the disease phenotype is correlated to multiple genetic loci and results from genetic–environmental interactions. One of the primary, still unresolved issues is the implementation of reliable diagnostic and prognostic markers. For clinical management improvement, predictors of curve progression are particularly needed. Recently, an epigenetic contribution to AIS development and progression was proposed; nevertheless, validation of data obtained in peripheral tissues and identification of the specific mechanisms and genes under epigenetic control remain limited. In this study, we propose a methodological approach for the identification of epigenetic markers of AIS progression through an original workflow based on the preliminary characterization of local expression of candidate genes in tissues directly involved in the pathology. The feasibility of the proposed methodological protocol has been originally tested here in terms of identification of the putative epigenetic markers of AIS progression, collection of the different tissues, retrieval of an appropriate amount and quality of RNA and DNA, and identification of suitable reference genes. Full article

Determining the tumor origin in humans is vital in clinical applications of molecular diagnostics. Metastatic cancer is usually a very aggressive disease with limited diagnostic procedures, despite the fact that many protocols have been evaluated for their effectiveness in prognostication. Research has shown that dysregulation in miRNAs (a class of non-coding, regulatory RNAs) is remarkably involved in oncogenic conditions. This research paper aims to develop a machine learning model that processes an array of miRNAs in 1097 metastatic tissue samples from patients who suffered from various stages of breast cancer. The suggested machine learning model is fed with miRNA quantitative read count data taken from The Cancer Genome Atlas Data Repository. Two main feature-selection techniques have been used, mainly Neighborhood Component Analysis and Minimum Redundancy Maximum Relevance, to identify the most discriminant and relevant miRNAs for their up-regulated and down-regulated states. These miRNAs are then validated as biological identifiers for each of the four cancer stages in breast tumors. Both machine learning algorithms yield performance scores that are significantly higher than the traditional fold-change approach, particularly in earlier stages of cancer, with Neighborhood Component Analysis and Minimum Redundancy Maximum Relevance achieving accuracy scores of up to 0.983 and 0.931, respectively, compared to 0.920 for the FC method. This study underscores the potential of advanced feature-selection methods in enhancing the accuracy of cancer stage identification, paving the way for improved diagnostic and therapeutic strategies in oncology. Full article

To the best of our knowledge, a novel concept of mode heterogeneity for the design of multimode devices is presented in this paper and applied to the design of scalable multimode power splitters. Based on a cascade of mode-dependent splitters and converters, we achieve beam splitting and mode conversion for four modes from $T{E}_0$ to $T{E}_3$ in the bandwidth from 1525 nm to 1560 nm. The measurements of the device at 1550 nm show excellent performance, with the insertion loss ranging from 0.16 dB to 0.63 dB, crosstalk all below −16.71 dB, and power uniformity between 0.026 dB and 0.168 dB. Full article

The rise in the antibiotic resistance of bacteria has increased scientific interest in the study of materials with unique mechanisms of antimicrobial action. This paper presents the results of studies on the antimicrobial activity of carbon materials and textiles decorated with them. A comparative analysis of the bactericidal and fungicidal activities of graphene oxide, electrochemically exfoliated multigraphene, carbon dots, and their combinations was performed. Microbiological studies on reference strains of E. coli, S. aureus, and C. albicans showed that graphene oxide inhibited growth with up to 98% efficiency. Electrochemically exfoliated multigraphene was less effective (up to 40%). This study found no significant antimicrobial activity of carbon dots and the combination of carbon dots with graphene oxide significantly weakened their effectiveness. However, the combination of electrochemically exfoliated multigraphene and carbon dots exhibits a synergistic effect (up to 76%). A study on the antimicrobial activity of decorated cotton textiles demonstrated the effectiveness of antimicrobial textiles with graphene oxide, electrochemically exfoliated multigraphene, and a combination of carbon dots with electrochemically exfoliated multigraphene. Full article

The pathogenicity of many bacteria, including Bacillus cereus and Staphylococcus aureus, depends on pore-forming toxins (PFTs), which cause the lysis of host cells by forming pores in the membranes of eukaryotic cells. Bioinformatic analysis revealed a region homologous to the Lys171-Gly250 sequence in hemolysin II (HlyII) from B. cereus in over 600 PFTs, which we designated as a “homologous peptide”. Three β-barrel PFTs were used for a detailed comparative analysis. Two of them—HlyII and cytotoxin K2 (CytK2)—are synthesized in Bacillus cereus sensu lato; the third, S. aureus α-toxin (Hla), is the most investigated representative of the family. Protein modeling showed certain amino acids of the homologous peptide to be located on the surface of the monomeric forms of these β-barrel PFTs. We obtained monoclonal antibodies against both a cloned homologous peptide and a 14-membered synthetic peptide, DSFNTFYGNQLFMK, as part of the homologous peptide. The HlyII, CytK2, and Hla regions recognized by the obtained antibodies, as well as an antibody capable of suppressing the hemolytic activity of CytK2, were identified in the course of this work. Antibodies capable of recognizing PFTs of various origins can be useful tools for both identification and suppression of the cytolytic activity of PFTs. Full article

Virtual-reality 3D modeling helps primary school students to develop creative thinking and problem-solving skills. Through hands-on practice, students can understand abstract concepts more intuitively, and can realize the combination of theory and practice. However, in conventional virtual 3D modeling teaching, students often lack immersive modeling experience, and the modeling method may not be in line with the cognitive way of thinking of primary school students, which, in turn, causes high cognitive load. Immersive virtual reality (IVR) environments provide students with more immersive and intuitive interactions, which can help promote students’ cognitive, emotional, and social development. Therefore, this study combined IVR with 3D virtual modeling to form an immersive virtual-reality-based 3D modeling approach (IVR-based 3D modeling) and designed a quasi-experiment to compare it with the conventional virtual reality 3D modeling approach (CVR-based 3D modeling) to explore its effectiveness. The results of the study show that the IVR-based 3D modeling approach significantly enhanced elementary school students’ creative thinking, including its sub-dimensions (e.g., challenge, imagination, and curiosity), when compared to the CVR-based 3D modeling approach. The same conclusion was reached for problem-solving skills. IVR-based 3D modeling also reduced students’ cognitive load during the learning process, especially in terms of mental effort. The results of the interviews complement the experimental results, and the learners’ perceptions of the new approach explain the experimental results to some extent. Full article

This study identified the practices of adaptation strategies to climate change in Jimma, Bedelle, Bonga, and Sokorru urban centers using a survey of 384 households, 55 key informant interviews, 4 focus group discussions, and field observations. A cross-sectional study design was employed from 2019 to 2021. The adaptive capacity of municipalities to reduce climate extreme events was rated as poor by the majority (51%), mostly reactive measures (76%). The climate hazards identified in four urban centers were riverine and flash floods, urban heat waves, landslides, and windstorms. The urban households practiced lifestyle modification, reduce paved surfaces, the use of air conditioner, planting trees, and multiple windows. The adaptation strategies practiced by municipalities include the relocation of prone areas, the support of basic amenities, the construction of protection walls, diversion ditches, the clearance of waterways and rivers, greenery, and park development. The adaptation actions were constrained by a lack of awareness, commitment, cooperation and coordination, adaptive capacity, and participation. Gray/physical infrastructures (costly but important) as adaptation actions were hampered by the low municipal capacity. We recommend that urban authorities should incorporate climate change adaptation strategies into urban planning and development proactively to ensure future resilient climate smart urban centers of southwest Ethiopia. Full article

Many corporations have now revised their value statements to showcase their commitment to sustainable development and green business due to the pressing issues of climate and environmental damage. Despite the importance of value statements that can direct companies to achieve sustainable goals, which kind of values can be perceived as organizational orientations towards sustainability remains unknown. This study explores how the general public views the inclusion of sustainable components in value statements from listed companies in Hong Kong by using Q-sort methodology (n = 30). Analyzing the final sample of 40 value statements extracted from 27 listed companies, we identified three factors related to sustainability, namely, Empowering business process management, Empowering customer-centric excellence, and Empowering sustainable progress. This study provides an additional component to the traditional triple bottom line by suggesting that the internal operation of a company is an emerging idea in understanding corporate sustainability. Full article

The design of Activity-Based Working (ABW) environments embraces workers’ continuous mobility enabled by technology and the mindset of seeking work zones that best support the task at hand. This paper focuses on aspects of workspace selection within a facility designed to support ABW, focusing on the overall occupancy dynamics, temporal context, and information capturing less-explored details of the physical environment. This study analyses the active use of a workspace in relation to work desk shapes, rectangular and trapezial. Drawing from a longitudinal dataset spanning 12 months from an ABW facility, capturing the active workstation usage of 964 occupants through individual computer logins, this study employs descriptive statistics to analyse the active use of workspace relative to total work hours over the year. Inferential statistical techniques are utilised to compare active use measurements between and within specific workspace areas, revealing significant differences and highlighting the importance of temporal and spatial contexts in workspace utilisation patterns. The presented results demonstrate both tendencies and statistically significant differences, confirming the relevance of the studied variables in examining workspace utilisation. The results show significant usage variations throughout the day across different zones of the observed workspace, with peak activity between 11:00 and 13:00 h for both work desk shapes. This study’s insights are relevant to improving the utilisation of facilities designed for ABW and contribute to a longstanding interest in designing and arranging workplaces to better fit the people who use them. Full article

Soybean vegetable oil is an important source of the human diet. However, the analysis of the genetic mechanism leading to changes in soybean oil content is still incomplete. In this study, a total of 227 soybean materials were applied and analyzed by a genome-wide association study (GWAS). There are 44 quantitative trait nucleotides (QTNs) that were identified as associated with oil content. A total of six, four, and 34 significant QTN loci were identified in Xiangyang, Hulan, and Acheng, respectively. Of those, 26 QTNs overlapped with or were near the known oil content quantitative trait locus (QTL), and 18 new QTNs related to oil content were identified. A total of 594 genes were located near the peak single nucleotide polymorphism (SNP) from three tested environments. These candidate genes exhibited significant enrichment in tropane, piperidine, and pyridine alkaloid biosynthesiss (ko00960), ABC transporters (ko02010), photosynthesis-antenna proteins (ko00196), and betalain biosynthesis (ko00965). Combined with the GWAS and weighted gene co-expression network analysis (WGCNA), four candidate genes (Glyma.18G300100, Glyma.11G221100, Glyma.13G343300, and Glyma.02G166100) that may regulate oil content were identified. In addition, Glyma.18G300100 was divided into two main haplotypes in the studied accessions. The oil content of haplotype 1 is significantly lower than that of haplotype 2. Our research findings provide a theoretical basis for improving the regulatory mechanism of soybean oil content. Full article

An original plasma chemical process initiated by microwave discharge in a mixture of metal and dielectric powders was applied to prepare specific materials, which consisted of microsized spherical particles of aluminum oxide covered with silver nanoparticles. The prepared materials are highly uniform in shape, size distribution, and composition. Their cytotoxicity was investigated using the human cell lines MCF7, HEK293T, A549, and VA-13 and the bacterial strains E. coli JW5503 (ΔtolC) and E. coli K12. Their cytotoxicity was found not to exceed the cytotoxicity of the starting materials. Thus, the prepared materials can be considered highly promising for catalysis and biotechnology applications. Full article

Society expects history to be objective and factual. Collectively history is the memory of the nation, that group, the imagined community that believes that it has always been together. It could even be said that the nation is about forgetting; forgetting that the people who make up that community were not always together as they are now, or the forgetting of those hurdles and hindrances that create obstacles to cohesion and continuity. Memory is collaborative by nature, and provides a legacy to society, a response to its own mortality in the future. This paper proposes to examine the case of subjective recounting of the past through a family memory of war, the forgetting, the gaps created in narratives to enable cohesion and to fit in with publicly acceptable discourse. It ultimately attempts to answer the question as to why it might be important to re-examine such stories of an individual nature, in a wider scope of the nation, and links those seemingly antinomic periods of time of past, present, and future, which are not as exclusive as might be believed. This paper focuses upon a deserter ancestor, going against the grain of traditional narratives. Traditionally, soldiers are considered by definition of what is expected from them in the national narrative, as ‘war heroes’. However, this paper examines the life of a military ancestor who, in reality, did not fit into that framework, and who deserted from the army (although never on the front line, thus avoiding being shot). Nevertheless, the multiple desertions (deserted five times in total, lost kit twice, was imprisoned, and was detained for desertion three times) only ‘resurfaced’ recently due to the availability of documentation and research carried out in archives. While the ancestor conformed socially to what was expected of him, the reality of his military files seems to reveal the contrary. Despite the high numbers of times that he did desert, he did also rejoin every time, and ended up spending 3 decades in the same military unit. Or, perhaps the manner in which society views soldiers pre- and post-WWI has been altered, and, as such, desertion was not once what it has become. Forgetting has been the norm in society regarding certain pasts that step outside of the national narrative, rather than remembering. This paper attempts to imagine the nation’s past in a different way, by including those who also deserted, an area of ill-defined research in military history. Full article

In this communication, I focus on Shawi forms of address used in Peruvian State posters during the COVID-19 pandemic. The COVID-19 pandemic took a heavy toll on the Peruvian Indigenous population. A recent study showed that Indigenous people had 3.18 times the risk of infection and 0.4 times the mortality risk of the general population in Peru. The Shawi have not been included among the most heavily affected. A preliminary descriptive and critical account of Peruvian State posters whereby languages such as Shawi and other Peruvian Indigenous languages (Awajun, Ashaninka, different varieties of Quechua, Shipibo, etc.) have been used to prevent the spread of COVID-19 is provided. Shawi seems to be the only language of the sample where information has been framed using first-person inclusive forms. This appears to have led to enhanced communal engagement in the suggested health-related practices. Additionally, opinions on the issue from local stakeholders are briefly discussed. While the results are derived solely from preliminary observations, my findings could serve as a basis for enhancing health communication strategies in other Indigenous contexts, utilizing linguistically informed intercultural approaches. Full article