The 2023 MDPI Annual Report has
been released!
 
26 pages, 1577 KiB  
Review
Neoantigen Identification and Dendritic Cell-Based Vaccines for Lung Cancer Immunotherapy
by Komal Kumari, Amarnath Singh, Archana Chaudhary, Rakesh Kumar Singh, Asheesh Shanker, Vinay Kumar and Rizwanul Haque
Vaccines 2024, 12(5), 498; https://doi.org/10.3390/vaccines12050498 (registering DOI) - 05 May 2024
Abstract
Immunotherapies can treat many cancers, including difficult-to-treat cases such as lung cancer. Due to its tolerability, long-lasting therapeutic responses, and efficacy in a wide spectrum of patients, immunotherapy can also help to treat lung cancer, which has few treatment choices. Tumor-specific antigens (TSAs) [...] Read more.
Immunotherapies can treat many cancers, including difficult-to-treat cases such as lung cancer. Due to its tolerability, long-lasting therapeutic responses, and efficacy in a wide spectrum of patients, immunotherapy can also help to treat lung cancer, which has few treatment choices. Tumor-specific antigens (TSAs) for cancer vaccinations and T-cell therapies are difficult to discover. Neoantigens (NeoAgs) from genetic mutations, irregular RNA splicing, protein changes, or viral genetic sequences in tumor cells provide a solution. NeoAgs, unlike TSAs, are non-self and can cause an immunological response. Next-generation sequencing (NGS) and bioinformatics can swiftly detect and forecast tumor-specific NeoAgs. Highly immunogenic NeoAgs provide personalized or generalized cancer immunotherapies. Dendritic cells (DCs), which originate and regulate T-cell responses, are widely studied potential immunotherapeutic therapies for lung cancer and other cancers. DC vaccines are stable, reliable, and safe in clinical trials. The purpose of this article is to evaluate the current status, limitations, and prospective clinical applications of DC vaccines, as well as the identification and selection of major histocompatibility complex (MHC) class I and II genes for NeoAgs. Our goal is to explain DC biology and activate DC manipulation to help researchers create extremely potent cancer vaccines for patients. Full article
(This article belongs to the Section Clinical Immunology)
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26 pages, 3619 KiB  
Article
Heavy Metal-Based Fungicides Alter the Chemical Fractions of Cu, Zn, and Mn in Vineyards in Southern Brazil
by Guilherme Wilbert Ferreira, Samya Uchoa Bordallo, Edenilson Meyer, Zayne Valéria Santos Duarte, Josué Klein Schmitt, Luana Paula Garlet, Allan Augusto Kokkonen da Silva, Jean Michel Moura-Bueno, George Wellington Bastos de Melo, Gustavo Brunetto, Tales Tiecher and Cledimar Rogério Lourenzi
Agronomy 2024, 14(5), 969; https://doi.org/10.3390/agronomy14050969 (registering DOI) - 05 May 2024
Abstract
This study aimed to evaluate Cu, Zn, and Mn fractions in vineyard soils in two important wine-growing regions in Latin America, which have soils with different soil organic matter (SOM) and clay contents. Soils were collected from vineyards aged 35, 37, and 39 [...] Read more.
This study aimed to evaluate Cu, Zn, and Mn fractions in vineyard soils in two important wine-growing regions in Latin America, which have soils with different soil organic matter (SOM) and clay contents. Soils were collected from vineyards aged 35, 37, and 39 years (Serra Gaúcha) and 13, 19, and 36 years (Campanha Gaúcha). In each region, soils were collected from a non-anthropized area, and in the oldest vineyards, the collection was conducted on and between the planting lines. The available and total Cu, Zn, and Mn contents were analyzed in addition to the chemical fractions. The ΔCu, ΔZn, and ΔMn were also calculated by subtracting the contents of each fraction of the vineyards from the reference areas. The use of fungicides promotes increased metal contents in vineyard soils. In soils with high SOM contents, Cu tended to increase in the organic fraction in surface and depth. In contrast, Zn increased in the residual fraction, and Mn increased in most bioavailable fractions. Cu and Zn increased their contents in soils with low SOM and clay contents in the organic and mineral fractions. Mn accumulated in the mineral and residual fractions. Full article
(This article belongs to the Special Issue Soil Pollution and Remediation in Sustainable Agriculture)
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16 pages, 3477 KiB  
Article
Polyethylene Film Surface Modification via Benzoic Acid Grafting
by Ana Luisa Grafia and Silvia Elena Barbosa
Polymers 2024, 16(9), 1291; https://doi.org/10.3390/polym16091291 (registering DOI) - 05 May 2024
Abstract
A polyethylene (PE) film surface modification method is proposed via benzoic acid (BA) alkylation grafting to improve the surface affinity to polar substances. The procedure involves sequentially spraying AlCl3 and BA onto the heat-softened PE surface. The occurrence of the alkylation reaction [...] Read more.
A polyethylene (PE) film surface modification method is proposed via benzoic acid (BA) alkylation grafting to improve the surface affinity to polar substances. The procedure involves sequentially spraying AlCl3 and BA onto the heat-softened PE surface. The occurrence of the alkylation reaction was evaluated through comparative chemical, morphological, and thermal analyses. It was demonstrated that the grafting reaction of BA onto the PE film surface took place, limited to the surface layer, while preserving the bulk properties of PE. The reaction resulted in the formation of aluminum benzoate complexes, which improved the surface affinity to polar compounds. The impact of grafting on the surface properties of PE was further assessed by comparing the behavior of PE films treated with BA and untreated PE films when painted with watercolors. The PE film grafted with BA exhibited increased affinity towards watercolors, providing strong evidence of a change in surface polarity from hydrophobic to hydrophilic. These findings indicate that the proposed methodology effectively renders the PE surface paintable, even with non-toxic water-based inks, making it suitable for applications such as packaging. Full article
24 pages, 1441 KiB  
Review
Pathophysiology and Advances in the Therapy of Cardiomyopathy in Patients with Diabetes Mellitus
by Patryk Graczyk, Aleksandra Dach, Kamil Dyrka and Andrzej Pawlik
Int. J. Mol. Sci. 2024, 25(9), 5027; https://doi.org/10.3390/ijms25095027 (registering DOI) - 05 May 2024
Abstract
Diabetes mellitus (DM) is known as the first non-communicable global epidemic. It is estimated that 537 million people have DM, but the condition has been properly diagnosed in less than half of these patients. Despite numerous preventive measures, the number of DM cases [...] Read more.
Diabetes mellitus (DM) is known as the first non-communicable global epidemic. It is estimated that 537 million people have DM, but the condition has been properly diagnosed in less than half of these patients. Despite numerous preventive measures, the number of DM cases is steadily increasing. The state of chronic hyperglycaemia in the body leads to numerous complications, including diabetic cardiomyopathy (DCM). A number of pathophysiological mechanisms are behind the development and progression of cardiomyopathy, including increased oxidative stress, chronic inflammation, increased synthesis of advanced glycation products and overexpression of the biosynthetic pathway of certain compounds, such as hexosamine. There is extensive research on the treatment of DCM, and there are a number of therapies that can stop the development of this complication. Among the compounds used to treat DCM are antiglycaemic drugs, hypoglycaemic drugs and drugs used to treat myocardial failure. An important element in combating DCM that should be kept in mind is a healthy lifestyle—a well-balanced diet and physical activity. There is also a group of compounds—including coenzyme Q10, antioxidants and modulators of signalling pathways and inflammatory processes, among others—that are being researched continuously, and their introduction into routine therapies is likely to result in greater control and more effective treatment of DM in the future. This paper summarises the latest recommendations for lifestyle and pharmacological treatment of cardiomyopathy in patients with DM. Full article
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18 pages, 351 KiB  
Article
Assessing the Relationship between Physical Health, Mental Health and Students’ Success among Universities in Lebanon: A Cross-Sectional Study
by Samer A. Kharroubi, Nayla Al-Akl, Sarah-Joe Chamate, Tarek Abou Omar and Rouba Ballout
Int. J. Environ. Res. Public Health 2024, 21(5), 597; https://doi.org/10.3390/ijerph21050597 (registering DOI) - 05 May 2024
Abstract
Background: Achieving high academic success is known to be influenced by many factors including, but not limiting to, physical and mental health. The present study aimed to assess the relationship between physical health, mental health, and university students’ success, and to explore the [...] Read more.
Background: Achieving high academic success is known to be influenced by many factors including, but not limiting to, physical and mental health. The present study aimed to assess the relationship between physical health, mental health, and university students’ success, and to explore the associations between these factors and their academic achievement. Methods: A cross-sectional, self-administered online survey was used to collect data from college students in three different universities in Lebanon during the Fall 2023 semester. Mental health was evaluated using validated screening tools for depression, anxiety, and stress, specifically the Patient Health Questionnaire (PHQ-9), the General Anxiety Disorder (GAD-7), and Cohen’s Perceived Stress Scale (PSS), respectively. Additionally, general questions regarding physical health and lifestyle factors were incorporated into the questionnaire. Academic achievement was measured using students’ grade point average (GPA). Results: A total of 261 students completed the self-administered online survey. The results revealed that approximately 42% and 36% of students were experiencing moderate to severe symptoms of depression and anxiety, respectively, and 75.1% of students exhibited symptoms of moderate stress. The majority of participants (99.2%) did not report any physical disability. Chi-square analysis revealed a significant association between mental health status (depression, anxiety, and stress) and GPA level (p = 0.03, p = 0.044, p = 0.015, respectively). Multiple logistic regression models identified eight correlates of GPA and highlighted the relationship between physical health and student success. For instance, students who considered themselves moderately active had lower odds of achieving a higher GPA than those who considered themselves active (OR = 0.41, p = 0.045). Conclusions: This is the first investigation into Lebanese university students’ academic success in relation to lifestyle and mental health profiles. The findings indicate that implementing public health programs and interventions targeting mental health and lifestyle behaviors is essential for enhancing student success. Full article
21 pages, 6282 KiB  
Article
A Numerical Investigation of Film Cooling under the Effects of Different Adverse Pressure Gradients
by Jingwei Shi, Zhonghao Hui, Li Zhou, Zhanxue Wang and Yongquan Liu
Aerospace 2024, 11(5), 365; https://doi.org/10.3390/aerospace11050365 (registering DOI) - 05 May 2024
Abstract
Film cooling needs to be applied to serpentine nozzles due to an increase in thermal load. Adverse pressure gradients (APGs) near the upper wall of such nozzles hinder the forward flow of the coolant, and they may even induce a recirculation zone that [...] Read more.
Film cooling needs to be applied to serpentine nozzles due to an increase in thermal load. Adverse pressure gradients (APGs) near the upper wall of such nozzles hinder the forward flow of the coolant, and they may even induce a recirculation zone that complicates the cooling of the film in serpentine nozzles under different APGs. In this study, the film cooling characteristics of a serpentine nozzle under various APGs are investigated through numerical simulations. The studied pressure gradients include strong, moderate, and weak APGs. The results show that the APG weakened the adhesion of the coolant to the surface, thereby reducing the film cooling effectiveness (FCE) and the convective heat transfer coefficient (CHTC). The stronger the APG, the greater its obstructive effect. However, the recirculation zone induced by the strong APG was composed of the coolant, and it adhered tightly to the wall, thereby significantly strengthening the FCE and CHTC. The CHTC under the moderate APG significantly increased due to the convergence of two jets ejected from different holes. For the four blowing ratios, the area-averaged FCE under the strong APG was 29.8% and 24.5% higher than that under the moderate and weak APGs, while the area-averaged ratios of the CHTC under the moderate APG were 1.6% and 16.7% higher than those under the strong and weak APGs. Therefore, more holes should be arranged on the film in the zones of moderate and weak APGs. Full article
(This article belongs to the Special Issue New Insights into Aerodynamics and Cooling in Gas Turbine Engines)
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24 pages, 2204 KiB  
Article
Modelling Rigid Body Potential of Small Celestial Bodies for Analyzing Orbit–Attitude Coupled Motions of Spacecraft
by Jinah Lee and Chandeok Park
Aerospace 2024, 11(5), 364; https://doi.org/10.3390/aerospace11050364 (registering DOI) - 05 May 2024
Abstract
The present study aims to propose a general framework of modeling rigid body potentials (RBPs) suitable for analyzing the orbit–attitude coupled motion of a spacecraft (S/C) near small celestial bodies, regardless of gravity estimation models. Here, ‘rigid body potential’ refers to the potential [...] Read more.
The present study aims to propose a general framework of modeling rigid body potentials (RBPs) suitable for analyzing the orbit–attitude coupled motion of a spacecraft (S/C) near small celestial bodies, regardless of gravity estimation models. Here, ‘rigid body potential’ refers to the potential of a small celestial body integrated across the finite volume of an S/C, assuming that the mass of the S/C has no influence on the motion of the small celestial body. First proposed is a comprehensive formulation for modeling the RBP including its associated force, torque, and Hessian matrix, which is then applied to three gravity estimation models. The Hessian of potential plays a crucial role in calculating the RBP. This study assesses the RBP via numerical simulations for the purpose of determining proper gravity estimation models and seeking modeling conditions. The gravity estimation models and the associated RBP are tested for eight small celestial bodies. In this study, we utilize distance units (DUs) instead of SI units, where the DU is defined as the mean radius of the given small celestial body. For a given specific distance in Dus, the relative error of the gravity estimation model at this distance has a similar value regardless of the small celestial body. However, the difference value between the potential and RBP depends on the DU; in other words, it depends on the size of the small celestial body. This implies that accurate gravity estimation models are imperative for conducting RBP analysis. The overall results can help develop a propagation system for orbit–attitude coupled motions of an S/C in the vicinity of small celestial bodies. Full article
(This article belongs to the Special Issue Deep Space Exploration)
12 pages, 314 KiB  
Article
Adolescent Mental Health: A Focus on Psychiatric Counseling from the Emergency Room of an Italian University Hospital in the Five Years from 2019 to 2023
by Maria Giuseppina Petruzzelli, Lucia Marzulli, Giuseppe Colacicco, Fabio Tarantino, Flora Furente, Alessandra Gabellone, Lucia Margari and Emilia Matera
Eur. J. Investig. Health Psychol. Educ. 2024, 14(5), 1248-1259; https://doi.org/10.3390/ejihpe14050082 (registering DOI) - 05 May 2024
Abstract
Recent studies have revealed increasingly worse and more complex mental health conditions in young people, which is reflected in a growing trend in emergency room (ER) visits for acute psychopathological symptoms (APSs). This phenomenon has become exacerbated in recent decades, with a peak [...] Read more.
Recent studies have revealed increasingly worse and more complex mental health conditions in young people, which is reflected in a growing trend in emergency room (ER) visits for acute psychopathological symptoms (APSs). This phenomenon has become exacerbated in recent decades, with a peak in the post-pandemic period. To better characterize the phenomenon, we investigated the change in the rate and type of ER counseling requests provided at the Child Neuropsychiatry Unit of the University Hospital of Bari, Italy over the period between 2019 and 2023 for subjects younger than 18 years old. For this purpose, we retrospectively analyzed a total number of 1073 urgent consultation reports retrieved through the reporting computerized operating system of our hospital. The distribution of the counseling requests provided for APSs and, among these, the distribution of the numbers of APSs and of the male: female ratio were significantly different over the years, with an increasing linear trend identified for APSs (p = 3.095 × 10−7), the average number of APSs (p = 3.598 × 10−7), and female gender prevalence (p = 0.03908), as well as for the patients with a history of psychotropic drug assumption (p = 0.0006319). A significant change in the number of urgent counseling requests received for eating disorders (p = 0.0007408), depression (p = 7.92 × 10−8), somatization (p = 4.03 × 10−6), self-harm (SA) (p = 1.358 × 10−6), and non-suicidal self-injury (NSSI) (p = 8.965 × 10−6) was found, with a significant increasing trend for anxiety (p = 0.0444), depression (p = 8.06 × 10−6), somatization (p = 0.004616), SA (p = 3.998 × 10−8), and NSSI (p = 5.074 × 10−7). The findings of our study support the hypothesis of an alarming progressive worsening of the mental health of children and adolescents, with an overlapping effect of the pandemic exacerbating the process. Full article
20 pages, 18440 KiB  
Article
Exploration of an Open Vocabulary Model on Semantic Segmentation for Street Scene Imagery
by Zichao Zeng and Jan Boehm
ISPRS Int. J. Geo-Inf. 2024, 13(5), 153; https://doi.org/10.3390/ijgi13050153 (registering DOI) - 05 May 2024
Abstract
This study investigates the efficacy of an open vocabulary, multi-modal, foundation model for the semantic segmentation of images from complex urban street scenes. Unlike traditional models reliant on predefined category sets, Grounded SAM uses arbitrary textual inputs for category definition, offering enhanced flexibility [...] Read more.
This study investigates the efficacy of an open vocabulary, multi-modal, foundation model for the semantic segmentation of images from complex urban street scenes. Unlike traditional models reliant on predefined category sets, Grounded SAM uses arbitrary textual inputs for category definition, offering enhanced flexibility and adaptability. The model’s performance was evaluated across single and multiple category tasks using the benchmark datasets Cityscapes, BDD100K, GTA5, and KITTI. The study focused on the impact of textual input refinement and the challenges of classifying visually similar categories. Results indicate strong performance in single-category segmentation but highlighted difficulties in multi-category scenarios, particularly with categories bearing close textual or visual resemblances. Adjustments in textual prompts significantly improved detection accuracy, though challenges persisted in distinguishing between visually similar objects such as buses and trains. Comparative analysis with state-of-the-art models revealed Grounded SAM’s competitive performance, particularly notable given its direct inference capability without extensive dataset-specific training. This feature is advantageous for resource-limited applications. The study concludes that while open vocabulary models such as Grounded SAM mark a significant advancement in semantic segmentation, further improvements in integrating image and text processing are essential for better performance in complex scenarios. Full article
(This article belongs to the Special Issue Advances in AI-Driven Geospatial Analysis and Data Generation)
13 pages, 3807 KiB  
Article
Detection of Dopamine Based on Aptamer-Modified Graphene Microelectrode
by Cuicui Zhang, Tianyou Chen, Yiran Ying and Jing Wu
Sensors 2024, 24(9), 2934; https://doi.org/10.3390/s24092934 (registering DOI) - 05 May 2024
Abstract
In this paper, a novel aptamer-modified nitrogen-doped graphene microelectrode (Apt-Au-N-RGOF) was fabricated and used to specifically identify and detect dopamine (DA). During the synthetic process, gold nanoparticles were loaded onto the active sites of nitrogen-doped graphene fibers. Then, aptamers were modified on the [...] Read more.
In this paper, a novel aptamer-modified nitrogen-doped graphene microelectrode (Apt-Au-N-RGOF) was fabricated and used to specifically identify and detect dopamine (DA). During the synthetic process, gold nanoparticles were loaded onto the active sites of nitrogen-doped graphene fibers. Then, aptamers were modified on the microelectrode depending on Au-S bonds to prepare Apt-Au-N-RGOF. The prepared microelectrode can specifically identify DA, avoiding interference with other molecules and improving its selectivity. Compared with the N-RGOF microelectrode, the Apt-Au-N-RGOF microelectrode exhibited higher sensitivity, a lower detection limit (0.5 μM), and a wider linear range (1~100 μM) and could be applied in electrochemical analysis fields. Full article
(This article belongs to the Special Issue Editorial Board Members' Collection Series: Aptamer Biosensors)
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16 pages, 4595 KiB  
Article
Modified Composite Biodegradable Mulch for Crop Growth and Sustainable Agriculture
by Bo Guo, Liyan Zhu, Xiaochan He, Xiaojun Zhou, Boru Dong and Jialei Liu
Polymers 2024, 16(9), 1295; https://doi.org/10.3390/polym16091295 (registering DOI) - 05 May 2024
Abstract
Using biodegradable films as a substitute for conventional polyolefin films has emerged as a crucial technology to combat agricultural white pollution. To address the shortcomings in the tensile strength, water vapor barrier properties, and degradation period of PBAT-based biodegradable films, this investigation aimed [...] Read more.
Using biodegradable films as a substitute for conventional polyolefin films has emerged as a crucial technology to combat agricultural white pollution. To address the shortcomings in the tensile strength, water vapor barrier properties, and degradation period of PBAT-based biodegradable films, this investigation aimed to create a composite film that could improve the diverse properties of PBAT films. To achieve this, a PBAT/PLA-PPC-PTLA ternary blend system was introduced in the study. The system effectively fused PBAT with PLA and PPC, as evidenced by electron microscopy tests showing no apparent defects on the surface and cross-section of the blended film. The developed ternary blend system resulted in a 58.62% improvement in tensile strength, a 70.33% enhancement in water vapor barrier properties, and a 30-day extension of the functional period compared to pure PBAT biodegradable films. Field experiments on corn crops demonstrated that the modified biodegradable film is more suitable for agricultural production, as it improved thermal insulation and moisture retention, leading to a 5.45% increase in corn yield, approaching the yield of traditional polyolefin films. Full article
(This article belongs to the Special Issue High Performance Polymer Membranes II)
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18 pages, 2255 KiB  
Systematic Review
Chordoma Genetic Aberrations and Targeted Therapies Panorama: A Systematic Literature Review
by Edoardo Agosti, Sara Antonietti, Marco Zeppieri, Tamara Ius, Alessandro Fiorindi, Alessandro Tel, Massimo Robiony, Pier Paolo Panciani and Marco Maria Fontanella
J. Clin. Med. 2024, 13(9), 2711; https://doi.org/10.3390/jcm13092711 (registering DOI) - 05 May 2024
Abstract
Background: Chordomas pose a challenge in treatment due to their local invasiveness, high recurrence, and potential lethality. Despite being slow-growing and rarely metastasizing, these tumors often resist conventional chemotherapies (CTs) and radiotherapies (RTs), making surgical resection a crucial intervention. However, achieving radical [...] Read more.
Background: Chordomas pose a challenge in treatment due to their local invasiveness, high recurrence, and potential lethality. Despite being slow-growing and rarely metastasizing, these tumors often resist conventional chemotherapies (CTs) and radiotherapies (RTs), making surgical resection a crucial intervention. However, achieving radical resection for chordomas is seldom possible, presenting therapeutic challenges. The accurate diagnosis of these tumors is vital for their distinct prognoses, yet differentiation is hindered by overlapping radiological and histopathological features. Fortunately, recent molecular and genetic studies, including extracranial location analysis, offer valuable insights for precise diagnosis. This literature review delves into the genetic aberrations and molecular biology of chordomas, aiming to provide an overview of more successful therapeutic strategies. Methods: A systematic search was conducted across major medical databases (PubMed, Embase, and Cochrane Library) up to 28 January 2023. The search strategy utilized relevant Medical Subject Heading (MeSH) terms and keywords related to “chordomas”, “molecular biology”, “gene aberrations”, and “target therapies”. The studies included in this review consist of preclinical cell studies, case reports, case series, randomized controlled trials, non-randomized controlled trials, and cohort studies reporting on genetic and biological aberrations in chordomas. Results: Of the initial 297 articles identified, 40 articles were included in the article. Two tables highlighted clinical studies and ongoing clinical trials, encompassing 18 and 22 studies, respectively. The clinical studies involved 185 patients diagnosed with chordomas. The tumor sites were predominantly sacral (n = 8, 44.4%), followed by clivus (n = 7, 38.9%) and lumbar spine (n = 3, 16.7%). Primary treatments preceding targeted therapies included surgery (n = 10, 55.6%), RT (n = 9, 50.0%), and systemic treatments (n = 7, 38.9%). Various agents targeting specific molecular pathways were analyzed in the studies, such as imatinib (a tyrosine kinase inhibitor), erlotinib, and bevacizumab, which target EGFR/VEGFR. Common adverse events included fatigue (47.1%), skin reactions (32.4%), hypertension (23.5%), diarrhea (17.6%), and thyroid abnormalities (5.9%). Clinical outcomes were systematically assessed based on progression-free survival (PFS), overall survival (OS), and tumor response evaluated using RECIST or CHOI criteria. Notably, stable disease (SD) occurred in 58.1% of cases, and partial responses (PRs) were observed in 28.2% of patients, while 13.7% experienced disease progression (PD) despite targeted therapy. Among the 22 clinical trials included in the analysis, Phase II trials were the most prevalent (40.9%), followed by I-II trials (31.8%) and Phase I trials (27.3%). PD-1 inhibitors were the most frequently utilized, appearing in 50% of the trials, followed by PD-L1 inhibitors (36.4%), CTLA-4 inhibitors (22.7%), and mTOR inhibitors (13.6%). Conclusions: This systematic review provides an extensive overview of the state of targeted therapy for chordomas, highlighting their potential to stabilize the illness and enhance clinical outcomes. Full article
(This article belongs to the Special Issue State of the Art—Treatment of Skull Base Diseases: Volume II)
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18 pages, 2713 KiB  
Article
Research on Summer Indoor Air Conditioning Design Parameters in Haikou City: A Field Study of Indoor Thermal Perception and Comfort
by Jiaxi Hu, Chengxi Lyu, Yinzhen Hou, Neng Zhu and Kairui Liu
Sustainability 2024, 16(9), 3864; https://doi.org/10.3390/su16093864 (registering DOI) - 05 May 2024
Abstract
Escalating global climate change and the intensification of urban heatwaves have led to an increase in summer air conditioning cooling energy consumption. This phenomenon is particularly critical in tropical regions, as it may trigger an energy crisis. The rational setting of indoor thermal [...] Read more.
Escalating global climate change and the intensification of urban heatwaves have led to an increase in summer air conditioning cooling energy consumption. This phenomenon is particularly critical in tropical regions, as it may trigger an energy crisis. The rational setting of indoor thermal design parameters can help conserve energy to the maximum extent while ensuring thermal comfort for occupants. This study selected Haikou City, a unique tropical city in China, as the research location. Indoor environment measurements and a questionnaire survey were conducted with participants, and the outdoor thermal environment sensitivity, population attributes and differences in thermal sensation, thermal neutral temperature, and comfort range were calculated and analyzed. The following results were obtained. Based on the overall population, long-term residence, and temporary residence classification, the indoor thermal comfort needs of residents in tropical cities in Haikou were effectively identified. The actual thermal neutral temperature of the overall population is 25.7 °C, and 90% of the acceptable thermal comfort temperature range is 23.2 °C–28.0 °C. The actual thermal neutral temperature of the regular residents is 27.3 °C, and 90% of the acceptable thermal comfort temperature range is 23.3 °C–31.4 °C. The actual thermal neutral temperature of the temporary population is 25.5 °C, and 90% of the acceptable thermal comfort temperature range is 23.0 °C–28.0 °C. These research results have an important reference value for improving the setting of the temperature of air conditioning in tropical areas in summer and further reducing energy consumption, which is conducive to sustainable development. Full article
11 pages, 2681 KiB  
Article
Genetic Diversity Assessment of Cupressus gigantea W. C. Cheng & L. K. Fu Using Inter-Simple Sequence Repeat Technique
by Ximei Ji, Yaxuan Jiang, Jianxin Li, Pei Lei and Fanjuan Meng
Agronomy 2024, 14(5), 970; https://doi.org/10.3390/agronomy14050970 (registering DOI) - 05 May 2024
Abstract
Cupressus gigantea W. C. Cheng & L. K. Fu is an endemic conifer tree species that is distributed widely along the northern portion of the deep gorge of the Yarlung Tsangbo River on the Tibetan Plateau. However, as a key plant species growing [...] Read more.
Cupressus gigantea W. C. Cheng & L. K. Fu is an endemic conifer tree species that is distributed widely along the northern portion of the deep gorge of the Yarlung Tsangbo River on the Tibetan Plateau. However, as a key plant species growing on the Tibetan plateau, C. gigantea has since become an endangered species due to habitat loss and degradation, overexploitation, and other factors. It has been listed as a first-grade national protected wild plant species in China. Accordingly, to conserve this plant species, we should obtain more information on its genetic structure. In this study, the genetic diversity and structure among 67 samples were evaluated by the inter-simple sequence repeat (ISSR) technique. Overall, 78 bands were produced with a molecular length of 200 bp to 3100 bp using 10 ISSR primers. The mean values for the average number of alleles (Na), effective number of alleles (Ne), Nei’s gene diversity (H), and Shannon’s information index (I) were 1.529, 1.348, 0.199, and 0.293, respectively. Additionally, the number of polymorphic loci (NPLs) and percentage of polymorphic loci (PPLs) averaged 41.25 and 52.90, respectively. Further, total variation among populations was 14.2%, while that within populations was 85.8%; accordingly, the within-population genetic differentiation was found to be significant (p < 0.001). These results demonstrated that a genetic structure model with K = 3 fitted the data best, which agreed with the unweighted pair group method with arithmetic average (UPGMA) cluster and the principal coordinate analysis (PCoA). These findings are beneficial for ensuring the development and genetic protection of C. gigantea populations in the future. Full article
(This article belongs to the Section Crop Breeding and Genetics)
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13 pages, 5155 KiB  
Article
Exposure to a Low-Oxygen Environment Causes Implantation Failure and Transcriptomic Shifts in Mouse Uteruses and Ovaries
by Asmaa Y. Ammar, Fatma M. Minisy, Hossam H. Shawki, Mohamed Mansour, Shabaan A. Hemeda, Abeer F. El Nahas, Ahmed H. Sherif and Hisashi Oishi
Biomedicines 2024, 12(5), 1016; https://doi.org/10.3390/biomedicines12051016 (registering DOI) - 05 May 2024
Abstract
Hypoxia is a condition in which tissues of the body do not receive sufficient amounts of oxygen supply. Numerous studies have elucidated the intricate roles of hypoxia and its involvement in both physiological and pathological conditions. This study aimed to clarify the impact [...] Read more.
Hypoxia is a condition in which tissues of the body do not receive sufficient amounts of oxygen supply. Numerous studies have elucidated the intricate roles of hypoxia and its involvement in both physiological and pathological conditions. This study aimed to clarify the impact of a forced low-oxygen environment in early pregnancy by exposing mice to low-oxygen conditions for 24–72 h after fertilization. The treatment resulted in the complete failure of blastocyst implantation, accompanied by vascular hyperpermeability in the uterus. A transcriptome analysis of the uterus revealed remarkable alterations in gene expression between control normoxic- and hypoxic-treatment groups. These alterations were characterized by the differentially expressed genes categorized into the immune responses and iron coordination. Furthermore, exposure to a low-oxygen environment caused apoptosis in the corpus luteum within the ovary and a reduction in progesterone secretion. Consequently, diminished plasma progesterone levels were considered to contribute to implantation failure in combination with the activation of the hypoxic pathway in the uterus. Additionally, previous studies have demonstrated the impact of hypoxic reactions on blastocyst development and the pre-implantation process in the endometrium. Our findings suggest that the corpus luteum exhibits elevated susceptibility to hypoxia, thereby elucidating a critical aspect of its physiological response. Full article
(This article belongs to the Section Molecular and Translational Medicine)
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18 pages, 4838 KiB  
Article
Quantitative Analysis of Formate Production from Plasma-Assisted Electrochemical Reduction of CO2 on Pd-Based Catalysts
by Jie Hu and Fuqiang Liu
AppliedChem 2024, 4(2), 174-191; https://doi.org/10.3390/appliedchem4020012 (registering DOI) - 05 May 2024
Abstract
The escalating levels of atmospheric CO2, primarily attributed to human activities, underscore the urgent need for innovative solutions to mitigate environmental challenges. This study delves into the electrochemical reduction of CO2 as a promising avenue for sustainable carbon capture and [...] Read more.
The escalating levels of atmospheric CO2, primarily attributed to human activities, underscore the urgent need for innovative solutions to mitigate environmental challenges. This study delves into the electrochemical reduction of CO2 as a promising avenue for sustainable carbon capture and utilization. Focused on the formation of formate (HCOO/HCOOH), a high-value product, the research explores the integration of nonthermal plasma (NTP) with electrochemical processes—an approach rarely studied in existing literature. A comprehensive investigation involves varying parameters such as plasma discharging voltage, carrier gas, discharging mode, electrolysis voltage, polarity, and plasma type. The electrochemical tests employ a 10 wt.% Pd/C catalyst, and formate production is quantitatively analyzed using NMR. Results reveal that NTP significantly enhances CO2 reduction, with key factors influencing formate yield elucidated. The study reveals the complexity of CO2 electrochemical reduction, providing novel insights into the synergistic effects of NTP. These findings contribute to advancing sustainable technologies for CO2 utilization, paving the way for more efficient and environmentally friendly processes in the pursuit of a carbon-neutral future. Full article
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10 pages, 280 KiB  
Article
Gender Differences in Anthropometric, Functional Capacity Measures and Quality of Life in Individuals with Intellectual and Developmental Disabilities
by Miguel Jacinto, Diogo Monteiro, Filipe Rodrigues, Susana Diz, Rui Matos, Nuno Amaro and Raul Antunes
J. Funct. Morphol. Kinesiol. 2024, 9(2), 84; https://doi.org/10.3390/jfmk9020084 (registering DOI) - 05 May 2024
Abstract
The aim of the of the current investigation was to investigate the possible differences concerning males and females in anthropometry, body composition, functional capacity, strength and quality of life variables. After obtaining signed informed consent, 37 participants (18 males; 19 females), with mean [...] Read more.
The aim of the of the current investigation was to investigate the possible differences concerning males and females in anthropometry, body composition, functional capacity, strength and quality of life variables. After obtaining signed informed consent, 37 participants (18 males; 19 females), with mean age of 39.08 and standard deviation of 11.66 years, voluntarily participated in this study. Anthropometry, body composition, functional capacity, strength, and quality of life were assessed using validated and reliable instruments and tests for this population. The males and females were compared using a Mann–Whitney U signed rank test. Significant differences were detected among the following variables, height (p = 0.028), body mass index (p = 0.033), fat mass (p = 0.002), muscle mass (p ≤ 0.001), phase angle (p = 0.005), medicine ball throwing strength (p = 0.010), and peak toque left knee (p = 0.028), with males showing better results in all the variables. The sample in this study showed differences in the anthropometric, composition, and strength variables. Studying this population can help ensure that everyone has equal access to services and adequate support for their personal needs, improving their quality of life. Full article
(This article belongs to the Section Kinesiology and Biomechanics)
21 pages, 1341 KiB  
Article
Novel Ransomware Detection Exploiting Uncertainty and Calibration Quality Measures Using Deep Learning
by Mazen Gazzan and Frederick T. Sheldon
Information 2024, 15(5), 262; https://doi.org/10.3390/info15050262 (registering DOI) - 05 May 2024
Abstract
Ransomware poses a significant threat by encrypting files or systems demanding a ransom be paid. Early detection is essential to mitigate its impact. This paper presents an Uncertainty-Aware Dynamic Early Stopping (UA-DES) technique for optimizing Deep Belief Networks (DBNs) in ransomware detection. UA-DES [...] Read more.
Ransomware poses a significant threat by encrypting files or systems demanding a ransom be paid. Early detection is essential to mitigate its impact. This paper presents an Uncertainty-Aware Dynamic Early Stopping (UA-DES) technique for optimizing Deep Belief Networks (DBNs) in ransomware detection. UA-DES leverages Bayesian methods, dropout techniques, and an active learning framework to dynamically adjust the number of epochs during the training of the detection model, preventing overfitting while enhancing model accuracy and reliability. Our solution takes a set of Application Programming Interfaces (APIs), representing ransomware behavior as input we call “UA-DES-DBN.” The method incorporates uncertainty and calibration quality measures, optimizing the training process for better more accurate ransomware detection. Experiments demonstrate the effectiveness of UA-DES-DBN compared to more conventional models. The proposed model improved accuracy from 94% to 98% across various input sizes, surpassing other models. UA-DES-DBN also decreased the false positive rate from 0.18 to 0.10, making it more useful in real-world cybersecurity applications. Full article
22 pages, 4731 KiB  
Article
Classification of Roadway Context and Target Speed for Multilane Highways in Thailand Using Fuzzy Expert System
by Chomphunut Sutheerakul, Nopadon Kronprasert, Wichuda Satiennam and Moe Sandi Zaw
Sustainability 2024, 16(9), 3865; https://doi.org/10.3390/su16093865 (registering DOI) - 05 May 2024
Abstract
The classification of roadway contexts and speeds is a critical step in the planning, design, and operation of highway infrastructure. In developing countries, road users encounter safety and operational issues due to poorly defined roadway contexts and inappropriately determined target speeds for a [...] Read more.
The classification of roadway contexts and speeds is a critical step in the planning, design, and operation of highway infrastructure. In developing countries, road users encounter safety and operational issues due to poorly defined roadway contexts and inappropriately determined target speeds for a highway network. This study developed an expert system for classifying roadway contexts and target speeds of multilane highway segments and applied the classification process to 16,235 km of multilane highways in Thailand’s highway network. The proposed methodology used a fuzzy decision mechanism to deal with subjective and imprecise expert judgment (e.g., low, high), many variables, and a complex evaluation process. This study used the Fuzzy Delphi method to identify the possible important factors influencing contexts and speeds and the Fuzzy Inference System method to reason factors to categorize multilane highway segments in Thailand into different classes of roadway contexts (e.g., rural, low-density suburban, high-density suburban, and urban highways) and target speeds (e.g., ≤50 km/h, 50–60 km/h, 60–70 km/h, 70–80 km/h, 80–90 km/h, 90–100 km/h, and 100 km/h). The study was based on data from questionnaire surveys of experts and field investigations of 120 highway segments. The results showed that roadside environments and activities influence the roadway contexts, while the target speeds are sensitive to the roadway characteristics and contexts. These findings support the need for changes in context-adapted highway design and speed management. The proposed expert system provided high accuracy (90.8%) in classifications of both roadway contexts and target speeds. The fuzzy expert system provides a systematic and structural framework for analyzing imprecise data in highway contextual and speed classifications and improving the clarity and accuracy of the evaluation process. The implementation of the fuzzy expert system has the potential to revolutionize the highway classification decision-making problem under uncertainty. Full article
20 pages, 976 KiB  
Review
Crop HTP Technologies: Applications and Prospects
by Shuyuan He, Xiuni Li, Menggen Chen, Xiangyao Xu, Fenda Tang, Tao Gong, Mei Xu, Wenyu Yang and Weiguo Liu
Agriculture 2024, 14(5), 723; https://doi.org/10.3390/agriculture14050723 (registering DOI) - 05 May 2024
Abstract
In order to rapidly breed high-quality varieties, an increasing number of plant researchers have identified the functions of a large number of genes, but there is a serious lack of research on plants’ phenotypic traits. This severely hampers the breeding process and exacerbates [...] Read more.
In order to rapidly breed high-quality varieties, an increasing number of plant researchers have identified the functions of a large number of genes, but there is a serious lack of research on plants’ phenotypic traits. This severely hampers the breeding process and exacerbates the dual challenges of scarce resources and resource development and utilization. Currently, research on crop phenotyping has gradually transitioned from traditional methods to HTP technologies, highlighting the high regard scientists have for these technologies. It is well known that different crops’ phenotypic traits exhibit certain differences. Therefore, in rapidly acquiring phenotypic data and efficiently extracting key information from massive datasets is precisely where HTP technologies play a crucial role in agricultural development. The core content of this article, starting from the perspective of crop phenomics, summarizes the current research status of HTP technology, both domestically and internationally; the application of HTP technology in above-ground and underground parts of crops; and its integration with precision agriculture implementation and multi-omics research. Finally, the bottleneck and countermeasures of HTP technology in the current agricultural context are proposed in order to provide a new method for phenotype research. HTP technologies dynamically monitor plant growth conditions with multi-scale, comprehensive, and automated assessments. This enables a more effective exploration of the intrinsic “genotype-phenotype-environment” relationships, unveiling the mechanisms behind specific biological traits. In doing so, these technologies support the improvement and evolution of superior varieties. Full article
(This article belongs to the Section Genotype Evaluation and Breeding)
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13 pages, 7654 KiB  
Article
Effects of the Nozzle Configuration with and without an Internal Guide Vane on the Efficiency in Cross-Flow Small Hydro Turbines
by Fredys Romero-Menco, Juan Pineda-Aguirre, Laura Velásquez, Ainhoa Rubio-Clemente and Edwin Chica
Processes 2024, 12(5), 938; https://doi.org/10.3390/pr12050938 (registering DOI) - 05 May 2024
Abstract
In this work, an experimental analysis of the performance of a cross-flow turbine, commonly referred to as a Michell–Banki turbine (MBT), is carried out for small-scale hydropower production in rural areas located in developing countries to support their social and economic development activities. [...] Read more.
In this work, an experimental analysis of the performance of a cross-flow turbine, commonly referred to as a Michell–Banki turbine (MBT), is carried out for small-scale hydropower production in rural areas located in developing countries to support their social and economic development activities. The study investigates how the efficiency of the MBT is influenced by the presence or absence of a nozzle, along with variations in the internal guide vane (GV) and its angle. The runner had 26 blades that were arranged symmetrically in the periphery between two circular plates. The designed MBT had the ability to generate a maximum of 100 W of power at a water flow rate and a head of 0.009 m3/s and 0.6311 m, respectively. The experimental tests were carried out using a hydraulic bench. The turbine efficiency without the inner GV was found to be higher than that of the turbine with the inner GV; i.e., it was found that the utilization of the GV did not enhance the efficiency of the MBT due to the occurrence of a choking effect. A maximum hydraulic efficiency of 85% was achieved in the turbine without an inner GV in comparison with the efficiency achieved (77%) with this device and an optimum opening angle of the GV of 24° (75% of opening). In this regard, the GV design should be carefully carried out to improve the MBT efficiency. Additionally, the effect of the GV shape on the MBT performance should be experimentally investigated to obtain a more general judgment regarding the role of this device. Full article
(This article belongs to the Special Issue Process and Modelling of Renewable and Sustainable Energy Sources)
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21 pages, 11447 KiB  
Article
Flexural Performance of Steel–Normal Concrete–Ultra-High-Performance Concrete Composite Slabs with Steel Ribs
by Songsong Guo, Chao Liu and Xiaogang Ma
Buildings 2024, 14(5), 1301; https://doi.org/10.3390/buildings14051301 (registering DOI) - 05 May 2024
Abstract
For steel–concrete composite bridges, the cracking of concrete in the tensile zone influences the serviceability of bridges and decreases their durability. UHPC, as a high-tensile and -durability material, is used to replace a part of the concrete to enhance the tensile performance. Thus, [...] Read more.
For steel–concrete composite bridges, the cracking of concrete in the tensile zone influences the serviceability of bridges and decreases their durability. UHPC, as a high-tensile and -durability material, is used to replace a part of the concrete to enhance the tensile performance. Thus, the steel–normal concrete–UHPC composite slab, as a new composite structure, is formed. This paper investigates the flexural behaviours of steel–normal concrete–UHPC composite slabs through a full-scale experiment, numerical simulation, and theoretical analysis. The research results indicate that (1) UHPC enhances the flexural performance of the tensile zone and delays the development of cracks. The initial cracking force of concrete increases from 44 kN to 91 kN. (2) UHPC effectively enhances the carrying capacity of composite slabs. A 50 mm UHPC layer makes the flexural bearing capacity of steel–concrete composite slabs increase by 13.51%. (3) The construction methods influence the initial cracking force of composite slabs. For full-span scaffolding construction, the initial cracking force decreases from 91 kN to 69 kN compared with construction without brackets. (4) The theoretical model considering the tensile contribution of cracking UHPC can accurately predict the bearing capacity of the composite slabs. And the theoretical values of the bearing capacity are lower than the experimental values, which makes the composite slabs safer in service. Full article
(This article belongs to the Section Building Structures)
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10 pages, 2229 KiB  
Article
Inkjet Printing of High-Color-Purity Blue Organic Light-Emitting Diodes with Host-Free Inks
by Hui Fang, Jiale Li, Shaolong Gong, Jinliang Lin and Guohua Xie
Molecules 2024, 29(9), 2147; https://doi.org/10.3390/molecules29092147 (registering DOI) - 05 May 2024
Abstract
Inkjet printing technology offers a unique approach to producing direct-patterned pixels without fine metal masks for active matrix displays. Organic light-emitting diodes (OLEDs) consisting of thermally activated delayed fluorescence (TADF) emitters facilitate efficient light emission without heavy metals, such as platinum and iridium. [...] Read more.
Inkjet printing technology offers a unique approach to producing direct-patterned pixels without fine metal masks for active matrix displays. Organic light-emitting diodes (OLEDs) consisting of thermally activated delayed fluorescence (TADF) emitters facilitate efficient light emission without heavy metals, such as platinum and iridium. Multi-resonance TADF molecules, characterized by their small full width at half maxima (FWHM), are highly suitable for the requirements of wide color-gamut displays. Herein, host-free TADF inks with a low concentration of 1 mg/mL were developed and inkjet-printed onto a seeding layer, concurrently serving as the hole-transporting layer. Attributed to the proof-of-concept of host-free inks printed on a mixed seeding layer, a maximum external quantum efficiency of 13.1% (improved by a factor of 21.8) was achieved in the inkjet-printed OLED, with a remarkably narrow FWHM of only 32 nm. Highly efficient energy transfer was facilitated by the effective dispersion of the sensitizer around the terminal emitters. Full article
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