One-third of humanity harbors a lifelong infection with Toxoplasma gondii, and probably about 80% are infected with human cytomegalovirus (CMV). This study aims to delineate the associations between toxoplasmosis and cognitive abilities and compare these to the associations with CMV. We evaluated the cognitive performance of 557 students, who had been examined for Toxoplasma and CMV infections, using intelligence, memory, and psychomotor tests. The results indicated cognitive impairments in seropositive individuals for both pathogens, with variations in cognitive impact related to sex and the Rh factor. Specifically, Toxoplasma infection was associated with lower IQ in men, whereas CMV was predominantly associated with worse performance by women when testing memory and reaction speeds. Analysis of the antibody concentrations indicated that certain Toxoplasma-associated cognitive detrimental effects may wane (impaired intelligence) or worsen (impaired reaction times) over time following infection. The findings imply that the cognitive impairments caused by both neurotropic pathogens are likely due to pathological changes in the brain rather than from direct manipulative action by the parasites. Full article

Building information modeling (BIM) has been used by the architectural and engineering disciplines to streamline the building design, construction, and management process, but there has been much more limited experience in extending the application to landscape design and implementation. This study integrated BIM software (Autodesk InfraWorks 2024.1) with a dynamic, process-oriented, conceptual hydrologic/hydraulic model (PCSWMM 2023, version 7.6.3665) to enhance the analytical tools for sustainable landscape design. We illustrate the model integration through a case study that links an existing nature-based solution (NbS) development, the PTT Metro Forest Park, Bangkok, Thailand, with theoretical new-build NbS for an adjacent property. A BIM school building was virtually situated on an empty lot beside the Metro Forest Park and seven NbS scenarios were run with design storms having 2-year, 5-year, and 100-year return intervals. The combination of a rain garden, permeable pavement, a retention pond, and a green roof was effective in sustainably managing runoff from the theoretical new-build site discharging to the Metro Forest. NbS design characteristics such as rain garden substrate depth and green roof area were optimized using the hydrologic/hydraulic model. Model results showed that even with the 100-year rainfall event, the existing Metro Forest pond storage capacity was sufficient so that flooding on the property would not occur. The consideration of connectivity between NbS features is facilitated by the modeling approach, which is important for NbS planning and assessment at a regional scale. Full article

A strong case can be made that the concept of naskh, “abrogation” or “annulment”, was the most potent weapon in the arsenal of Muslim polemicists seeking to convert Jews (Burton‘s Encyclopaedia of the Qurʾān is highly informative but deals almost exclusively with naskh in its internal Islamic contexts, e.g., hermeneutics and legal theory). Naskh did not necessarily involve any rejection of Jewish scripture or tradition as fraudulent or corrupt. It rested on the simple premise, explicitly confirmed by the Qur’an, that the deity may alter or replace His legislation over the course of time. In the first part of this paper, I will briefly review the topic, adding some texts and observations that, to the best of my knowledge, have not appeared in the academic literature (comprehensively surveyed in Adang’s Muslim Writers on Judaism and the Hebrew Bible: From Ibn Rabban to Ibn Hazm, 1996; also in Adang and Schmidtke’s Polemics (Muslim-Jewish) in Encyclopedia of Jews in the Islamic World, 2010). The bulk of this paper will consist of a fairly detailed summary of an unpublished tract on naskh written by Rashīd al-Dīn Faḍlullāh Hamadānī (RD) (1247–1318), himself a Jewish convert to Islam and a monumental politician, cultural broker, historian, and author. Full article

This study aimed to examine the spatio-temporal variations in the atmospheric boundary layer height (ABLH) over the Tarim Basin (TB). Monthly ABLH data from the ERA-Interim dataset from January 1979 to December 2018 were used. Periodicity analysis and the Mann–Kendall Abrupt Changes test were employed to identify the change cycle and abrupt change year of the boundary layer height. The Empirical Orthogonal Function (EOF) method was utilized to determine the spatial distribution of the boundary layer height, and the RF method was used to establish the relationship between the ABLH and influencing factors. The results demonstrated that the highest values of ABLH (over 1900 m) were observed in the middle parts of the study area in June, and the ABLH exhibited a significant increase over the TB throughout the study period. Abrupt changes in the ABLH were also identified in 2004, as well as in 2-, 5-, 9-, and 15-year changing cycles. The first EOF ABLH mode indicated that the middle and northeast regions are relatively high ABLH areas within the study area. Additionally, the monthly variations in ABLH show a moderately positive correlation with air temperature, while exhibiting a negative correlation with air pressure and relative humidity. Full article

Pathological processes often change the mechanical properties of cells. Increased rigidity could be a marker of cellular malfunction. Erythrocytes are a type of cell that deforms to squeeze through tiny capillaries; changes in their rigidity can dramatically affect their functionality. Furthermore, differences in the homeostatic elasticity of the cell can be used as a tool for diagnosis and even for choosing the adequate treatment for some illnesses. More accurate types of equipment needed to study biomechanical phenomena at the single-cell level are very costly and thus out of reach for many laboratories around the world. This study presents a simple and low-cost technique to study the rigidity of red blood cells (RBCs) through the application of electric fields in a hand-made microfluidic chamber that uses a capacitor principle. As RBCs are deformed with the application of voltage, cells are observed under a light microscope. From mechanical force vs. deformation data, the elastic constant of the cells is determined. The results obtained with the capacitor-based method were compared with those obtained using optical tweezers, finding good agreement. In addition, P. falciparum-infected erythrocytes were tested with the electric field applicator. Our technique provides a simple means of testing the mechanical properties of individual cells. Full article

Bézier and B-spline curves are foundational tools for curve representation in computer graphics and computer-aided geometric design, with their intersection computation presenting a fundamental challenge in geometric modeling. This study introduces an innovative algorithm that quickly and effectively resolves intersections between Bézier and B-spline curves. The number of intersections between the two input curves within a specified region is initially determined by applying the resultant of a polynomial system and Sturm’s theorem. Subsequently, the potential region of the intersection is established through the utilization of the pseudo-curvature-based subdivision scheme and the bounding box detection technique. The projected Gauss-Newton method is ultimately employed to efficiently converge to the intersection. The robustness and efficiency of the proposed algorithm are demonstrated through numerical experiments, demonstrating a speedup of 3 to 150 times over traditional methods. Full article

To enhance the energy efficiency of exploding foil initiator systems (EFIs) and mitigate energy loss due to ablation in the bridge-wing regions, a low-energy bridge-wing-thickened EFI chip was designed and fabricated. Computational analysis revealed that increasing the thickness of the bridge flanks significantly reduces ablation within the bridge region during the electrical explosion. The refinement of the design led to the adoption of a bridge flank thickness of 19 μm, with the bridge area dimensions specified as 0.25 mm × 0.25 mm × 4 μm. This bridge-wing-thickened EFI chip was produced by employing micro-electro-mechanical systems (MEMS) technology and underwent rigorous performance evaluations. The empirical results closely matched the computational predictions, thereby corroborating the precision of the proposed model in simulating the temperature distribution seen during the explosion process. Notably, this enhanced EFI design achieves a flyer velocity of 3800 m/s at a condition of 900 V/0.22 μF, signifying a significant advancement in EFI system efficiency and performance. Full article

Wireless communication represents the basis for the next generation of vehicle safety systems, whereas visible light communication (VLC) is one of the most suitable technologies for this purpose. In this context, this work introduces a novel VLC receiver architecture that integrates a field-of-view (FoV) adaptation mechanism in accordance with the optical noise generated by the sun. In order to demonstrate the benefits of this concept, a VLC prototype was experimentally tested in an infrastructure-to-vehicle (I2V) VLC configuration, which uses an LED traffic light as the transmitter. At the receiver side, an automatic FoV adaptation mechanism was designed based on a mechanical iris placed in front of a photodetector. Adjustments were made based on the values recorded by a multi-angle light sensor, built with an array of IR photodiodes covering an elevation from 0° to 30° and an azimuth from −30° to 30°. Depending on the incidence of solar light, the mechanical iris can adjust the FoV from ±1° to ±22°, taking into account both the light irradiance and the sun’s position relative to the VLC receiver. For experimental testing, two identical VLC receivers were used: one with an automatic FoV adjustment, and the other with a ±22° fixed FoV. The test results performed at a distance of 50 m, in the presence of solar irradiance reaching up to 67,000 µW/cm², showed that the receiver with a fixed FoV saturated and lost the communication link most of the time, whereas the receiver with an adjustable FoV maintained an active link throughout the entire period, with a bit error rate (BER) of less than 10⁻⁷. Full article

Median arcuate ligament syndrome (MALS) is an uncommon condition characterized by the compression of the celiac trunk by the median arcuate ligament. Due to the anatomical proximity to the foregut, MALS has significant implications in hepato-pancreato-biliary (HPB) surgery. It can pose complications in pancreatoduodenectomy and orthotopic liver transplantation, where the collateral arterial supply from the superior mesenteric artery is often disrupted. The estimated prevalence of MALS in HPB surgery is approximately 10%. Overall, there is consensus for a cautious approach to MALS when embarking on complex foregut surgery, with a low threshold for intraoperative median arcuate ligament release or hepatic artery reconstruction. The role of endovascular intervention in the management of MALS prior to HPB surgery continues to evolve, but more evidence is required to establish its efficacy. Recognizing the existing literature gap concerning optimal management in this population, we describe our tertiary center experience as a clinical algorithm to facilitate decision-making. Research question: What is the significance and management of median arcuate ligament syndrome in patients undergoing hepato-pancreato-biliary surgery? Full article

Air pollution in upper northern Thailand raises health concerns. This study examined trends and associations between air pollutants and respiratory diseases, focusing on COPD and lung cancer during haze (December–May) and non-haze (June–November) seasons in upper northern Thailand from 2013 to 2022. This study utilized data from the Pollution Control Department and Chiang Mai Provincial Public Health. The key air pollutants included PM₁₀, PM_2.5, SO₂, NO₂, CO, and O₃. Respiratory disease data included fatality rates for lung cancer and COPD and the re-admission rate for COPD. Results indicated peak air pollutant levels and COPD re-admission rates in March, with PM_2.5 concentrations exceeding air quality standards from January to April. During haze periods, COPD fatality and re-admission rates significantly increased (mean difference: 0.43 and 4.23 per 1000-case population, respectively; p < 0.001), while lung cancer fatality rates were higher without statistical significance. Pearson correlation analysis found positive correlations between PM₁₀, PM_2.5, O₃, and NO₂ concentrations and COPD re-admission and fatality rates at 0–1 month lag times, with a declining trend observed at subsequent lag intervals of 2 to 3 months. Overall, this study highlights the predictable pattern of air pollution in the region, correlating with higher COPD fatality and re-admission rates. Full article

Pressure–temperature estimates of a xenolith found within a post-obduction granodiorite in southern New Caledonia provide evidence for subcrustal, granulite facies, peak crystallisation conditions (ca. 850 °C—8.5 ± 1.0 kbar), followed by isobaric cooling to 700 °C, and final decompression with partial rehydration at ca. 650 °C—3.5 kbar. The xenolith, dated at 24.7 Ma (U-Pb zircon), i.e., the same age as the granodiorite host rock, has low SiO₂ (35.5 wt%) and high Al₂O₃ (33.2 wt%) contents, suggesting that it is the restite of a previous melting episode, while the elevated Ca (Ba and Sr) contents suggest mantle metasomatism. Although the concentrations of Rb, K, Ca, Ba, and Sr have been strongly modified, some geochemical (REE patterns and some “immobile” trace element ratios) and isotopic (Sr and Nd isotopic ratios, U-Pb zircon age) characteristics of the granulite facies xenolith are similar to those of the xenoliths found in other Late Oligocene intrusions in southern New Caledonia; therefore, this rock is interpreted to be related to an early magmatic episode. The rock protolith was emplaced and equilibrated at the base of the crust where it underwent ductile deformation. Younger ascending magma picked it up and they eventually crystallised together at a shallow crustal level, near the tectonic sole of the ophiolite. The recrystallisation and ductile deformation at ~8.5 kbar suggest that a rheological discontinuity existed at about 25–28 km, probably representing the Moho. It is concluded that a continental crust of normal thickness must have existed beneath New Caledonia at about 24 Ma, i.e., 10 Ma after obduction. Full article

Aluminum (Al) components of high quality often require an optimal ratio of lightness and favorable mechanical properties. In order to improve the physical-mechanical properties of Al, an aluminum oxide (Al₂O₃) film is usually formed on the surface of Al, which itself is characterized by high strength, hardness, corrosion resistance, and other technical properties. Unfortunately, depending on the conditions, the oxide film may be formed from different crystal phases on the Al surface, which are not always of desirable quality, i.e., the α-Al₂O₃ phase. The present review demonstrates that the properties of the Al₂O₃ film may be improved by Al processing with a laser beam according to the scheme: Al (Al alloy) → electrochemical anodizing → treatment with laser irradiation → α-Al₂O₃. Both Al substrate and the anodizing electrolyte affect the phase transformation of anodic Al₂O₃. Laser irradiation of the Al₂O₃ surface leads to high heating and cooling rates, which may promote the formation of a highly crystalline α-Al₂O₃ phase on anodic Al₂O₃. Full article

Cropland is a vital resource intricately connected to food security. Currently, the issue of cropland abandonment poses a serious threat to food production and supply, presenting a significant challenge to rural economies and the stability of the food supply chain. The hilly and cloudy regions of southwest China are particularly affected by cropland abandonment, presenting significant challenges in accurately mapping the distribution of abandoned cropland due to fragmentation and heavy cloud pollution. Therefore, this study focuses on Mingshan County, located in Ya’an City, Sichuan Province, China, as the study area. Utilizing Google Earth Engine (GEE) and a random forest algorithm, a method integrating multi-source data from Landsat 8, Sentinel-2, and Sentinel-1 is proposed to extract abandoned cropland spanning from 2018 to 2022. This study analyzes spatial and temporal characteristics, employing the Geodetector with optimal parameters to explore the underlying mechanisms. The findings reveal the following: (1) The method achieves an overall accuracy of land use classification surpassing 88.67%, with a Kappa coefficient exceeding 0.87. Specifically, the accuracy for identifying abandoned cropland reaches 87.00%. (2) From 2018 to 2022, the abandonment rate in Mingshan County fluctuated between 4.58% and 5.77%, averaging 5.03%. The lowest abandonment rate occurred in 2019–2020, while the highest was observed in 2020–2021. (3) Cropland abandonment is influenced by both natural and social factors. Elevation and slope are the main driving factors, alongside factors such as distance to road, town, and residential settlement that all significantly contribute to abandonment trends. These five factors exhibit positive correlation with the abandonment rate, with distance to the river showing relatively weaker explanatory power. Full article

A circularly polarized wearable antenna operating in the 2.45/5.8 GHz ISM dual bands is proposed, which consists of a coplanar waveguide-fed rectangular monopole antenna and two parasitic branches. The monopole rectangular radiation patch can generate 2.45 and 7 GHz frequency bands and has linear polarization characteristics. By adding L-shaped parasitic branches and L-like grounded branches on both sides of the monopole, the 7 GHz operating frequency band can be moved to the 5.8 GHz frequency band, and circular polarization characteristics can be achieved in both the 2.45 and 5.8 GHz frequency bands. The size of the antenna is 48.7 mm × 42.1 mm × 1.016 mm. The simulated −10 dB impedance bandwidths of the antenna are 1.8–2.66 GHz and 5.48–6.98 GHz, respectively. The 3 dB axial ratio bandwidths are 2.34–2.67 GHz and 5.58–6.39 GHz, respectively, and it has dual-band circular polarization characteristics. In addition, the radiation characteristics of the antenna and its safety performance near the human body were analyzed. The antenna prototype has been constructed, and the measurement and simulation results have good consistency. The proposed antenna is suitable for application in wearable devices. Full article

Bacterial ghosts (BGs) are hollow bacterial cell envelopes with intact cellular structures, presenting as promising candidates for various biotechnological and biomedical applications. However, the yield and productivity of BGs have encountered limitations, hindering their large-scale preparation and multi-faceted applications of BGs. Further optimization of BGs is needed for the commercial application of BG technology. In this study, we screened out the most effective lysis protein ID52-E-W4A among 13 mutants based on phage ID52 lysis protein E and optimized the liquid culture medium for preparing Escherichia coli Nissle 1917 (EcN). The results revealed a significantly higher lysis rate of ID52-E-W4A compared to that of ID52-E in the 2xYT medium. Furthermore, EcN BGs were cultivated in a fermenter, achieving an initial OD₆₀₀ as high as 6.0 after optimization, indicating enhanced BG production. Moreover, the yield of ID52-E-W4A-induced BGs reached 67.0%, contrasting with only a 3.1% yield from φX174-E-induced BGs. The extended applicability of the lysis protein ID52-E-W4A was demonstrated through the preparation of Salmonella pullorum ghosts and Salmonella choleraesuis ghosts. Knocking out the molecular chaperone gene slyD and dnaJ revealed that ID52-mediated BGs could still undergo lysis. Conversely, overexpression of integral membrane enzyme gene mraY resulted in the loss of lysis activity for ID52-E, suggesting that the lysis protein ID52-E may no longer rely on SlyD or DnaJ to function, with MraY potentially being the target of ID52-E. This study introduces a novel approach utilizing ID52-E-W4A for recombinant expression, accelerating the BG formation and thereby enhancing BG yield and productivity. Full article

For the last 30 years, Piscirickettsia salmonis has caused major economic losses to the aquaculture industry as the aetiological agent for the piscirickettsiosis disease. Replacing the current interventions, based on antibiotics, with natural alternatives (e.g., organic acids) represents a priority. With this study, we aimed to better understand their biological mechanism of action in an in vitro model of infection with salmon epithelial cells (CHSE-214). Our first observation revealed that at the sub-inhibitory concentration of 0.5%, the organic acid blend (Aq) protected epithelial cell integrity and significantly reduced P. salmonis invasion. The MIC was established at 1% Aq and the MBC at 2% against P. salmonis. The sub-inhibitory concentration significantly increased the expression of the antimicrobial peptides Cath2 and Hepcidin1, and stimulated the activity of the innate immune effector iNOS. The increase in iNOS activity also led to higher levels of nitric oxide (NO) being released in the extracellular space. The exposure of P. salmonis to the endogenous NO caused an increase in bacterial lipid peroxidation levels, a damaging effect which can ultimately reduce the pathogen’s ability to attach or multiply intracellularly. We also demonstrate that the increased NO release by the host CHSE-214 cells is a consequence of direct exposure to Aq and is not dependent on P. salmonis infection. Additionally, the presence of Aq during P. salmonis infection of CHSE-214 cells significantly mitigated the expression of the pro-inflammatory cytokines IL-1β, IL-8, IL-12, and IFNγ. Taken together, these results indicate that, unlike antibiotics, natural antimicrobials can weaponize the iNOS pathway and secreted nitric oxide to reduce infection and inflammation in a Piscirickettsia salmonis in vitro model of infection. Full article

This study follows 99 subjects vaccinated with Pfizer/BioNTech COVID-19 vaccines over two years, with particular focus on the last year of observation (between days 360 and 720). The response to the vaccination was assessed with Diasorin’s SARS-CoV-2 TrimericSpike IgG. Screening for SARS-CoV-2 infection was performed with Abbott’s SARS-CoV-2 Nucleocapsid IgG immunoassay. Data from questionnaires were also analyzed. Two years after the first vaccine dose administration, 100% of the subjects were positive for anti-spike SARS-CoV-2 IgG and the median antibody level was still high (3600 BAU/mL), dropping insignificantly over the last year. Simultaneously, a substantial increase in seropositivity in anti-nucleocapsid SARS-CoV-2 IgG was noted, reaching 33%. There was no statistically significant agreement between anti-N seropositivity and reported COVID-19. Higher anti-spike concentrations and lower COVID-19 incidence was seen in the older vaccinees. It was noted that only subjects boosted between days 360 and 720 showed an increase in anti-spike IgG concentrations. The higher antibody concentrations (median 7440 BAU/mL) on day 360 were noted in participants not infected over the following year. Vaccination, including booster administrations, and natural, even unrecognized, contact with SARS-CoV-2 entwined two years after the primary vaccination, leading to high anti-spike antibody concentrations. Full article

Bartonella is an intracellular parasitic zoonotic pathogen that can infect animals and cause a variety of human diseases. This study investigates Bartonella infection in small mammals in Yunnan Province, China, focusing on tissue tropism. A total of 333 small mammals were sampled from thirteen species, three orders, four families, and four genera in Heqing and Gongshan Counties. Conventional PCR and real-time quantitative PCR (qPCR) were utilized for detection and quantification, followed by bioinformatic analysis of obtained DNA sequences. Results show a 31.5% detection rate, varying across species. Notably, Apodemus chevrieri, Eothenomys eleusis, Niviventer fulvescens, Rattus tanezumi, Episoriculus leucops, Anourosorex squamipes, and Ochotona Thibetana exhibited infection rates of 44.4%, 27.7%, 100.0%, 6.3%, 60.0%, 23.5%, and 22.2%, respectively. Genetic analysis identified thirty, ten, and five strains based on ssrA, rpoB, and gltA genes, with nucleotide identities ranging from 92.1% to 100.0%. Bartonella strains were assigned to B. grahamii, B. rochalimae, B. sendai, B. koshimizu, B. phoceensis, B. taylorii, and a new species identified in Episoriculus leucops (GS136). Analysis of the different tissues naturally infected by Bartonella species revealed varied copy numbers across different tissues, with the highest load in spleen tissue. These findings underscore Bartonella’s diverse species and host range in Yunnan Province, highlighting the presence of extensive tissue tropism in Bartonella species naturally infecting small mammalian tissues. Full article

Duplex stainless steels are widely used in many fields due to their excellent corrosion resistance and mechanical properties. However, it is a challenge to achieve duplex microstructure and excellent properties through additive manufacturing. In this work, a 0.09% N 25Cr-type duplex stainless steel was prepared by additive manufacturing (AM) and heat treatment, and its corrosion resistance was investigated. The results show that, compared with S32750 duplex stainless steel prepared by a conventional process, the combination value of film resistance and charge transfer resistance of AM duplex stainless steel was increased by 3.2–5.5 times and the pitting potential was increased by more than 100 mV. The disappearance of residual thermal stress and the reasonable distribution of Cr and N elements in the two phases are the reasons for the improvement of the corrosion resistance of AM duplex stainless steel after heat treatment. In addition, the extremely high purity of AM duplex stainless steel with no visible inclusions resulted in a higher corrosion resistance exhibited at lower pitting-resistance-equivalent number values. Full article

In this study, we investigated the hepatoprotective effects of an ethanol extract of Sophora flavescens Aiton (ESF) on an alcohol-induced liver disease mouse model. Alcoholic liver disease (ALD) was caused by the administration of ethanol to male C57/BL6 mice who were given a Lieber−DeCarli liquid diet, including ethanol. The alcoholic fatty liver disease mice were orally administered ESF (100 and 200 mg/kg bw/day) or silymarin (50 mg/kg bw/day), which served as a positive control every day for 16 days. The findings suggest that ESF enhances hepatoprotective benefits by significantly decreasing serum levels of aspartate transaminase (AST) and alanine transaminase (ALT), markers for liver injury. Furthermore, ESF alleviated the accumulation of triglyceride (TG) and total cholesterol (TC), increased serum levels of superoxide dismutase (SOD) and glutathione (GSH), and improved serum alcohol dehydrogenase (ADH) activity in the alcoholic fatty liver disease mice model. Cells and organisms rely on the Kelch-like ECH-associated protein 1- Nuclear factor erythroid 2-related factor 2 (Keap1-Nrf2) system as a critical defensive mechanism in response to oxidative stress. Therefore, Nrf2 plays an important role in ALD antioxidant responses, and its level is decreased by increased reactive oxidation stress (ROS) in the liver. ESF increased Nrf2, which was decreased in ethanol-damaged livers. Additionally, four polyphenol compounds were identified through a qualitative analysis of the ESF using LC-MS/MS. This study confirmed ESF’s antioxidative and hangover-elimination effects and suggested the possibility of using Sophora flavescens Aiton (SF) to treat ALD. Full article

Transport electrification is essential for reducing CO₂ emissions, and technologies such as hybrid and range-extended electric vehicles will play a crucial transitional role. Such vehicles employ an internal combustion engine for on-board chemical energy conversion. The Wankel rotary engine should be an excellent candidate for this purpose, offering a high power-to-weight ratio, simplicity, compactness, perfect balance, and low cost. Until recently, however, it has not been in production in the automotive market, due, in part, to relatively low combustion efficiency and high fuel consumption and unburnt hydrocarbon emissions, which can be traced to constraints on flame speed, an elongated combustion chamber, and relatively low compression ratios. This work used large eddy simulations to study the in-chamber flow in a peripherally ported 225cc Wankel rotary engine, providing insight into these limitations. Flow structures created during the intake phase play a key role in turbulence production but the presence of the pinch point inherent to Wankel engine combustion chambers inhibits flame propagation. Two efficiency-enhancement technologies are introduced as disruptive solutions: (i) pre-chamber jet ignition and (ii) a two-stage rotary engine. These concepts overcome the traditional efficiency limitations and show that the Wankel rotary engine design can be further enhanced for its role as a range extender in electrified vehicles. Full article