Monitoring hydrogen sulfide (H₂S) in living organisms is very important because H₂S acts as a regulator in many physiological and pathological processes. Upregulation of endogenous H₂S concentration has been shown to be closely related to the occurrence and development of tumors, atherosclerosis, neurodegenerative diseases and diabetes. Herin, a novel fluorescent probe HND with aggregation-induced emission was designed. Impressively, HND exhibited a high selectivity, fast response (1 min) and low detection limit (0.61 μM) for H₂S in PBS buffer (10 mM, pH = 7.42). Moreover, the reaction mechanism between HND and H₂S was conducted by Job’s plot, HR-MS, and DFT. In particular, HND was successfully employed to detect H₂S in HeLa cells. Full article

Microgreens are a new, rapidly growing group of foodstuffs. The decorative function of these is often accompanied by their use in traditional dishes. As microgreens are eaten at very early stages, when the development of the epidermis is at its minimum, the bioavailability of minerals will be found to be higher in microgreens then in mature vegetables. So, microgreens can be an excellent functional food, especially for mineral-deficient populations, although they can also be a source of contaminants such as heavy metals or nitrates and nitrites. The purpose of this study was to measure the levels of selected heavy metals (i.e., cadmium, arsenic, lead, chromium, aluminium, zinc, copper, cobalt, molybdenum, manganese, vanadium, boron, antimony, thallium, titanium and strontium), as well as nitrates and nitrites, in microgreens at various stage of vegetation, using uncommon oilseed plants like nigella—Nigella sativa L., safflower—Carthamus tinctorius L., and camelina—Camelina sativa L. The examined microgreens of rare oilseed plants may be a source of contaminants and nitrates. The mineral profile of these plants is mainly determined by their genotype. Microgreens’ cultivation involves compliance with safety standards and replicable conditions to guarantee that the highest nutritional value is reached at the lowest possible contaminant level. Full article

ChatGPT (GPT-3.5), an intelligent Web-based tool capable of conducting text-based conversations akin to human interaction across various subjects, has recently gained significant popularity. This surge in interest has led researchers to examine its impact on numerous fields, including education. The aim of this paper is to investigate the perceptions of undergraduate students regarding ChatGPT’s utility in academic environments, focusing on its strengths, weaknesses, opportunities, and threats. It responds to emerging challenges in educational technology, such as the integration of artificial intelligence in teaching and learning processes. The study involved 257 students from two university departments in Greece—namely primary and early childhood education pre-service teachers. Data were collected using a structured questionnaire. Various methods were employed for data analysis, including descriptive statistics, inferential analysis, K-means clustering, and decision trees. Additional insights were obtained from a subset of students who undertook a project in an elective course, detailing the types of inquiries made to ChatGPT and their reasons for recommending (or not recommending) it to their peers. The findings offer valuable insights for tutors, researchers, educational policymakers, and ChatGPT developers. To the best of the authors’ knowledge, these issues have not been dealt with by other researchers. Full article

In the current century, urbanization and the development of the construction industry have led to the generation of construction and demolition waste (CDW), imposing pressure on ecology and the environment. This has attracted the attention of industry personnel and researchers. This work discusses the current research on recycled coarse or fine aggregate, mainly focusing on the physical, mechanical and durability properties of sustainable concrete with recycled coarse or fine aggregate. Furthermore, it also summarizes CDW recycling and classification in major countries, the production processes of recycled aggregate, and the physical properties. This review will provide a reference for the application of concrete with recycled coarse or fine aggregate. Moreover, this review notes that replacing natural aggregates with both coarse and fine recycled aggregates awaits further experimental exploration. Full article

This research aims to promote diversity and inclusion among higher education students by examining the integration of technology into project-based learning (PBL) for English as a foreign language (EFL) teacher candidates. Based on a mixed-methods approach and convenience sampling (n = 84 participants), this study involved pre-service teachers who collaboratively employed several authoring tools to create 16 digital comic strips for teaching English. The focus of the project was on inclusivity, cultural diversity, and affective education. This study consisted of five stages corresponding to different critical thinking skills: comprehension, negotiation, creation, presentation, and evaluation. The instruments used for quantitative data included a pre/post-survey based on two validated scales. Qualitative data were gathered through class discussions and semi-structured interviews. The results, analyzed through SPSS and QDA Miner Lite, revealed that teacher candidates lacked prior experience using digital tools to create EFL-inclusive materials. However, the study also highlighted increased awareness of inclusive education and strong advocacy for the integration of transformative technology in teacher training programs. Full article

Glass ceramics (GCs) containing PbS quantum dots (QDs) are prepared for temperature sensing. Broadband emissions are detected in the GCs when PbS QDs are precipitated from the glasses, and emissions centers are modulated from 1250 nm to 1960 nm via heat treatments. The emission centers of GCs exhibit blue-shifts when environment temperatures increase from room temperature to 210 °C. Importantly, the shift values of emission centers increase linearly with the test temperature, which is beneficial for applications in temperature sensing. A temperature sensor based on PbS QDs GC is heat-treated at 500 °C for 10 h, possesses the highest sensitivity of 0.378 nm/°C, and exhibits excellent stability and repeatability at high temperatures (up to 210 °C). Moreover, GC fibers are fabricated by using the GCs as the fiber core. The sensitivity of the temperature-sensing sensor of the GC fibers is also demonstrated and the sensitivity is as high as 0.558 nm/°C. The designed PbS QDs GCs provide a significant materials base for the manufacturing of fluorescent temperature sensors and the GC fibers offer significant opportunities for temperature detection in complex, integrated and compact devices. Full article

Soil is now a central issue on the European as well as the national political agenda, as it represents a fundamental ecosystem for human survival on the planet. Today, more than ever, its protection and proper use in various contexts (agricultural, natural, urban) require stringent policies that can be implemented immediately. The difficult reversibility of urban transformations is the main threat to the ecosystem integrity of soil. Starting from this statement, the main objective of the proposed work is to analyze how the main European countries (Italy, France, Germany, and Spain) are addressing the issue of the goal of zero net land take by 2050 by examining the current laws and strategies. The results highlight how the regulatory aspect plays a key role in managing the phenomenon and how the absence of a national framework law can generate strong distortions and different interpretations of the soil ecosystem. The analysis of the Nature Restoration Law, adopted by the European Commission in July 2023, enables us to assess whether the regulations and measures adopted by the major European countries align with the European Union’s trends. Through a comparative perspective, the study aims to contribute to a comprehensive understanding of sustainable development practices and provide valuable insights for policymakers, urban planners, and academics. Full article

A series of novel thio-derivatives of d-glucosamine has been synthesized using double inversion procedures at the C3 atom. New compounds were applied as ligands for the diethylzinc addition to benzaldehyde and the products of the addition were obtained with a low to good enantiomeric ratio. The direction and the level of the asymmetric induction were highly dependent on the type of protecting groups on the nitrogen and sulfur atoms. Full article

To solve the problem of environmental pollution caused by road traffic, alternatives to vehicles with internal combustion engines are often proposed. As such, eco-mobility microvehicles have significant potential in the fight against environmental pollution, but only on the condition that they are widely accepted and that they replace the vehicles that predominantly pollute the environment. With this in mind, this study aims to elucidate the main variables that influence the acceptability of these vehicles, using prediction models based on binary logistic regression and a multilayer artificial neural network—a multilayer perceptron (ANN). The data of a random sample obtained via an online questionnaire, answered by 503 inhabitants of Belgrade (Serbia), were used for training and testing the model. A multilayer perceptron with 9 and 7 neurons in two hidden layers, a hyperbolic tangent activation function in the hidden layer, and an identity function in the output layer performed slightly better than the binary logistic regression model. With an accuracy of 85%, a precision of 79%, a recall of 81%, and an area under the ROC curve of 0.9, the multilayer perceptron model recognized the influential variables in predicting acceptability. The results of the model indicate that a respondent’s relationship to their current environmental pollution, the frequency of their use of modes of transport such as bicycles and motorcycles, their mileage for commuting, and their personal income have the greatest influence on the acceptability of using eco-mobility vehicles. Full article

This paper explains how the so-called Einstein locality is to be understood in the Schrödinger picture of quantum mechanics. This notion is fully compatible with the Bell non-locality exhibited by entangled states. Contrary to the belief that quantum mechanics is incomplete, it is, As a matter of fact, its overcompleteness, as exemplified by the different pictures of quantum physics, that points to the same underlying reality. Full article

The article presents an advanced two-dimensional (2D) computational fluid dynamics (CFD) model of an external gear pump which considers relief grooves. Relief grooves are limiting design features for the flow process of this type of pump, and their influence in existing studies is considered by a three-dimensional (3D) model only. The structural modification proposed by the authors is beyond the possibilities of real implementation, but it gives the possibility to precisely model the pump’s design features. In contrast to the existing studies (using 3D CFD), the proposed advanced 2D model requires significantly fewer computing resources. Numerical experiments were carried out using the 2D model at different pump operating modes depending on the rotation frequency (950–1450 min⁻¹) and pressure load (5–150 bar). The numerical results were validated by a real-world experiment for the same pump operating modes using an existing laboratory experimental setup. An analysis of the CFD model and real experiment results was carried out by determining a quantitative index of match (FIT), which varies in the range of 97.93–99.82%. This proves the performance of the proposed CFD model, which can be further used as a part of more complex hydraulic systems models. Full article

The available randomised controlled trials (RCTs) assessing the influence of peritoneal interposition flaps (PIF) on the reduction of symptomatic lymphoceles (sLCs) post robot-assisted radical prostatectomy (RARP) do not constitute a sufficient follow-up (FU) to assess the long-term effects. The PIANOFORTE trial was the first of these RCTs, showing no sLC reduction at the 3-month FU. Therefore, all 232 patients from the PIANOFORTE trial were invited for long-term FU. One hundred seventy-six patients (76%) presented themselves for FU and constituted the study group (SG). The median FU duration was 43 months. No significant differences in group allocation or LC endpoints at 90 days were observed between SG patients and patients not presenting themselves for the FU. During the FU period, four patients (2.3%) in the SG developed sLCs, and six patients (3.4%) developed asymptomatic lymphoceles (aLCs), which persisted in five patients (2.9%). There were no significant differences between PIF and non-PIF regarding sLC/aLC formation or persistence, newly developed complications, stress urinary incontinence or biochemical/clinical tumour recurrence. Therefore, this long-term FU confirms the primary outcomes of the PIANOFORTE trial that, while PIF does not impact complications or functionality, it does not reduce sLC/aLC rates. Furthermore, it shows the potential occurrence of LC after the third postoperative month. Full article

There has been very limited investigation regarding the genetic diversity of Mycobacterium tuberculosis (MTb) strains isolated from human immunodeficiency virus (HIV)-infected patients in Mexico. In this study, we isolated 93 MTb strains from pulmonary and extrapulmonary samples of HIV-infected patients treated in a public hospital in Mexico City to evaluate the genetic diversity using spoligotyping and mycobacterial interspersed repetitive unit-variable-number tandem-repeat (MIRU-VNTR) typing (based on 24 loci). The cohort comprised 80 male and 13 female individuals. There was a positive correlation between a high HIV viral load (>100,000 copies) and extrapulmonary tuberculosis (TB) (r = 0.306, p = 0.008). Lineage 4 was the most frequent lineage (79 strains). In this lineage, we found the H clade (n = 24), including the Haarlem, H3, and H1 families; the T clade (n = 22), including T1 and T2; the X clade (n = 15), including X1 and X3; the LAM clade (n = 14), including LAM1, LAM2, LAM3, LAM6, and LAM9; the S clade (n = 2); Uganda (n = 1); and Ghana (n = 1). We also found 12 strains in the EAI clade belonging to lineage 1, including the EAI2-Manila and EAI5 families. Interestingly, we identified one strain belonging to the Beijing family, which is part of lineage 2. One strain could not be identified. This study reports high genetic diversity among MTb strains, highlighting the need for a molecular epidemiological surveillance system that can help to monitor the spread of these strains, leading to more appropriate measures for TB control in HIV-infected patients. Full article

Pteridines are important cofactors for many biological functions of all living organisms, and they were first discovered as pigments of insects, mainly in butterfly wings and the eye and body colors of insects. Most of the information on their structures and biosynthesis has been obtained from studies with the model insects Drosophila melanogaster and the silkworm Bombyx mori. This review discusses, and integrates into one metabolic pathway, the different branches which lead to the synthesis of the red pigments “drosopterins”, the yellow pigments sepiapterin and sepialumazine, the orange pigment erythropterin and its related yellow metabolites (xanthopterin and 7-methyl-xanthopterin), the colorless compounds with violet fluorescence (isoxanthopterin and isoxantholumazine), and the branch leading to tetrahydrobiopterin, the essential cofactor for the synthesis of aromatic amino acids and biogenic amines. Full article

Maritime emergency communication facilities play a crucial role in establishing communication links between land and sea, serving as essential communication means for maintaining maritime safety, disaster response, and emergency rescue operations. With the increasing frequency of marine activities, the rapid response capability of maritime emergency communication is becoming increasingly critical. With their characteristics of high-speed mobility, broad coverage and flexibility, aircraft serve as carriers for emergency communication facilities. The selection of aircraft bases is paramount in meeting the requirement of rapid response for maritime emergency communication. In this paper, we present a multi-objective optimization model for site selection by considering the coverage capabilities of different carriers. The model incorporates hierarchical coverage of unmanned aerial vehicles (UAVs) and helicopters with a genetic algorithm. Through a case study of the Bohai Sea, this paper verifies the feasibility and effectiveness of the model. Full article

The deadwood contributes to an increase in soil heterogeneity due to the changing the microrelief (by the formation of windthrow-soil complexes), as well as changes in physical and chemical characteristics of decaying wood directly during xylolysis. We hypothesized that fallen logs as an element of microrelief influence the species composition and cover structure of vascular plants. We studied the influence of Picea abies (L.) Karst fallen logs of moderate and advanced decay stages on the horizontal distribution and heterogeneity of vascular plant cover in different microsite types (small boreal grass type, blueberry type, small boreal grass-blueberry type, herbs, and blueberry type) in old-growth middle taiga spruce forest in the Kivach State Nature Reserve (Republic of Karelia, Russia). The fallen deadwood acts as a factor of heterogeneity, causing reversible changes in the homogeneity of the original plant cover. The decaying logs influence the horizontal distribution of small herbs by changing the occurrence and density of shoots of Oxalis acetosella L., Maianthemum bifolium (L.) F.W. Schmidt, Vaccinium myrtillus L., and Vaccinium vitis-idaea L., as well as the occurrence of Luzula pilosa (L.) Willd. and Calamagrostis arundinacea (L.) Roth. Its impact on the heterogeneity parameters can be traced up to 20 cm from the log. The differences in vascular plant cover between fallen logs and the surrounding forest floor depend on the soil conditions of the microsite. The heterogeneity of conditions created by the logs smoothed out with increasing decay class, resulting in decreasing differences in the heterogeneity parameters of vascular plant cover between deadwood and forest floor. The changes in the homogeneity of the initial vascular plant cover by deadwood and the gradual smoothing of heterogeneity between the logs and the forest floor in rich and poor conditions have different, mainly opposite, trends. Finally, the structure of the vegetation cover reaches a state that is typical of particular growth conditions beyond deadwood. Full article

Shadow banking is a main way for the financial market to serve the real economy today, and this process is closely related to systemic risk. This study examines the impact of shadow banking associated with sustainable development in China’s banking on systemic risk. We analyze the data obtained from a rich sample of 31 listed commercial banks in China and shadow banking represented by wealth management products (WMPs) by constructing a dynamic complex interbank network model. The results show that the risks and vulnerabilities generated by shadow banking spread out through the interbank network and cause systemic risk to increase. The effect operates through increasing the number of default banks, reducing banks’ survival rate and profit, and forcing central bank bailout funds expansion. However, it has a positive impact in terms of augmenting liquidity and enhancing investment opportunities. Furthermore, the variability in the influence of different categories of shadow banking is assessed, emphasizing that short-term shadow banking exerts a more pronounced impact on systemic risk. In addition, the heterogeneity of the shadow banking effect on different types of commercial banks is explored, revealing that local and rural commercial banks experience a more conspicuous effect compared to state-owned and joint-stock banks. Our findings highlight that improving external supervision, promoting financial internal governance, and constraining credit linkages are vital for alleviating the increase in risks in shadow banking and maintaining the sustainable development of banking. Full article

Aim: C1q/TNF-related protein 6 (CTRP6) is a novel adipokine involved in insulin resistance. Thus, we aim to investigate the expression profile of CTRP6 in the plasma, adipose tissue and placenta of GDM patients and mice. Methods: Chinese Han pregnant women (GDM n = 9, control n = 10) with a scheduled caesarean section delivery were recruited. A number of high-fat diet (HFD) induced-pregnancy C57BL/6 mice were chosen as an animal model of GDM. Circulating levels of CTRP6 and adiponectin were examined by ELISA. CTRP6 expression in adipose tissue and placenta were detected by real-time qPCR and WB. Result: Plasma CTRP6 levels were decreased during the first and second trimesters in mice, as well as the second and third trimesters in patients, while they were increased at delivery in GDM patients and mice. Plasma CTRP6 levels were significantly correlated with WBC, systolic pressure, diastolic pressure and fasting blood glucose. Moreover, CTRP6 mRNA expression in the subcutaneous (sWAT) and omental white adipose tissue (oWAT), as well as in the placenta, was significantly higher in GDM human patients at cesarean delivery. Furthermore, the mRNA expression of Ctrp6 was increased in the sWAT and visceral WAT (vWAT), whilst decreased in the interscapular brown adipose tissue (iBAT), of GDM mice at cesarean delivery. Conclusion: Dynamically expressed CTRP6 may be served as a candidate target for treatment of GDM. Full article

Encapsulation with polymers is a well-known strategy to stabilize and functionalize nanomaterials and tune their physicochemical properties. Amphiphilic copolymers are promising in this context, but their structural diversity and complexity also make understanding and predicting their behavior challenging. This is particularly the case in complex media which are relevant for intended applications in medicine and nanobiotechnology. Here, we studied the encapsulation of gold nanoparticles and quantum dots with amphiphilic copolymers differing in their charge and molecular structure. Protein adsorption to the nanoconjugates was studied with fluorescence correlation spectroscopy, and their surface activity was studied with dynamic interfacial tensiometry. Encapsulation of the nanoparticles without affecting their characteristic properties was possible with all tested polymers and provided good stabilization. However, the interaction with proteins and cells significantly depended on structural details. We identified statistical copolymers providing strongly reduced protein adsorption and low unspecific cellular uptake. Interestingly, different zwitterionic amphiphilic copolymers showed substantial differences in their resulting bio-repulsive properties. Among the polymers tested herein, statistical copolymers with sulfobetaine and phosphatidylcholine sidechains performed better than copolymers with carboxylic acid- and dimethylamino-terminated sidechains. Full article

Fatty infiltration of the rotator cuff muscles is very common following rotator cuff tears and is one of the most important factors in determining treatment. Current clinical practice relies on subjective evaluation of fatty infiltration through categorical scoring based on the Goutallier classification system. The Dixon magnetic resonance imaging (MRI) sequence provides flexibility in selecting echo times for water–fat separation. The Dixon method, therefore, has the potential to provide robust and high-quality fat quantification that allows for more accurate calculation of fat fraction (%Fat) of the rotator cuff muscles than the Goutallier classification system. However, significant variance exists in sequencing and post-processing methodology within the recent application of Dixon sequences to quantify rotator cuff fatty infiltration. In this paper, we conducted a systematic review to synthesize the relevant literature utilizing Dixon sequencing for the quantification of rotator cuff fatty infiltration. The literature search was extracted from 1094 articles, with 12 studies included in the final review. Regardless of the varying sequencing pattern and post-processing techniques among studies, the findings suggest the Dixon method is reliable for quantitatively calculating the fat fraction of the rotator cuff muscles, even at very low levels of fatty infiltration. In addition, a quantitative difference in fat fraction was observed between participants with different degrees of tear vs. those without any shoulder pathologies. Multi-point Dixon imaging has the potential to be utilized clinically to objectively quantify fatty infiltration and may lead to improved clinical decision making for patients with rotator cuff tears. Full article

As an important support for power systems with high penetration of sustainable energy, the energy storage system (ESS) has changed the traditional model of simultaneous implementation of electricity production and consumption. Its installed capacity under the source-grid-load scenario is rising year by year, contributing to sustainable development, but it faces the problems of insufficient utilization and benefits. This study analyzes the functional combination of ESS under source-grid-load scenarios. A comprehensive benefit evaluation method of energy storage projects (ESPs), based on a fuzzy decision-making trial and evaluation laboratory (DEMATEL) and super-efficiency data envelopment analysis (DEA), is proposed. Firstly, the functional requirements of energy storage in source-grid-load scenarios are explored, and the characteristics of various functions are analyzed to form eight functional combination schemes. Secondly, index modeling is carried out from three aspects—the whole life cycle cost, functional combination benefits, and social and environmental benefits—and a comprehensive benefit evaluation index system of ESP is proposed. Then, the intuitionistic trapezoidal fuzzy number (ITFN) is combined with DEMATEL to form an effective analysis method for the input–output relationship of the indices, and the comprehensive evaluation is realized based on the SE-DEA model. Compared with other methods, this model can ensure the objectivity and stability of the evaluation results in ESP evaluation. Finally, the effectiveness of the proposed evaluation method and the rationality of the functional combination are verified under source-grid-load scenarios. The calculation results show that in the application scenario of source-grid-load, after adopting the functional combination scheme formulated in this article, the comprehensive investment benefits of ESPs have been improved. Moreover, the source side effect is at its best, with an efficiency value of 2.209. Full article

Pancreatic cystic lesions (PCL) are frequently encountered in clinical practice and some are referred to surgery due to their neoplastic risk or malignant transformation. The management of PCL involves complex decision-making, with postoperative surveillance being a key component for long-term outcomes, due to the potential for recurrence and postoperative morbidity. Unfortunately, the follow-up of resected patients is far from being optimal and there is a lack of consensus on recommendations with regard to timing and methods of surveillance. Here, we summarize the current knowledge on the postoperative surveillance of neoplastic pancreatic cysts, focusing on the mechanisms and risk factors for recurrence, the recurrence rates according to the initial indication for surgery, the final result of the surgical specimen and neoplastic risk in the remaining pancreas, as well as the postsurgical morbidity comprising pancreatic exocrine insufficiency, metabolic dysfunction and diabetes after resection, according to the type of surgery performed. We analyze postsurgical recurrence rates and morbidity profiles, as influenced by different surgical techniques, to better delineate at-risk patients, and highlight the need for tailored surveillance strategies adapted to preoperative and operative factors with an impact on outcomes. Full article