The 2023 MDPI Annual Report has
been released!
 
12 pages, 1602 KiB  
Article
Development of a Web Application for Simulating Plasma Drug Concentrations in Patients with Zolpidem Intoxication
by Hwa Jun Cha, Sungpil Han, Kwan Cheol Pak and Hyungsub Kim
Pharmaceutics 2024, 16(5), 689; https://doi.org/10.3390/pharmaceutics16050689 (registering DOI) - 20 May 2024
Abstract
Zolpidem is a widely prescribed hypnotic Z-drug used to treat short-term insomnia. However, a growing number of individuals intentionally overdose on these drugs. This study aimed to develop a predictive tool for physicians to assess patients with zolpidem overdose. A population pharmacokinetic (PK) [...] Read more.
Zolpidem is a widely prescribed hypnotic Z-drug used to treat short-term insomnia. However, a growing number of individuals intentionally overdose on these drugs. This study aimed to develop a predictive tool for physicians to assess patients with zolpidem overdose. A population pharmacokinetic (PK) model was established using digitized data obtained from twenty-three healthy volunteers after a single oral administration of zolpidem. Based on the final PK model, a web application was developed using open-source R packages such as rxode2, nonmem2rx, and shiny. The final model was a one-compartment model with first-order absorption and elimination with PK parameters, including clearance (CL, 16.9 L/h), absorption rate constant (Ka, 5.41 h−1), volume of distribution (Vd, 61.7 L), and lag time (ALAG, 0.394 h). Using the established population PK model in the current study, we developed a web application that enables users to simulate plasma zolpidem concentrations and visualize their profiles. This user-friendly web application may provide essential clinical information to physicians, ultimately helping in the management of patients with zolpidem intoxication. Full article
(This article belongs to the Special Issue Population Pharmacokinetics and Its Clinical Applications)
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18 pages, 952 KiB  
Article
Make-or-Buy Policy Decision in Maintenance Planning for Mobility: A Multi-Criteria Approach
by Tommaso Ortalli, Andrea Di Martino, Michela Longo and Dario Zaninelli
Logistics 2024, 8(2), 55; https://doi.org/10.3390/logistics8020055 (registering DOI) - 20 May 2024
Abstract
Background: The ongoing technical innovation is fully involving transportation sector, converting the usual mass-transit system toward a sustainable mobility. Make-or-buy decision are usually adopted to assess different solutions in terms of costs-benefits to put in place strategic choices regarding in-house production or [...] Read more.
Background: The ongoing technical innovation is fully involving transportation sector, converting the usual mass-transit system toward a sustainable mobility. Make-or-buy decision are usually adopted to assess different solutions in terms of costs-benefits to put in place strategic choices regarding in-house production or from an external supplier. This can also be reflected on maintenance operations, thus replicating a similar approach to transport companies involved. Method: A decision-making model by means of a multi-criteria analysis can lead make-or-buy choices adapted to maintenance. A brief introduction into the actual mobility context is provided, evaluating global and national trends with respect to the mobility solutions offered. Then, a focus is set on maintenance approaches in mobility sector and the need of a make-or-buy decision process is considered. The decision-making path is developed through a multi-criteria framework based on eigenvector weighing assessment, where different Key Performance Indicators (KPIs) are identified and exploited to assess the maintenance approach at stake. Results: A comparison among different scenarios considered helped in identify the solution offered to the transport operator. In particular, for the case study of interest a −35% decrease in maintenance specific cost and −44% in cost variability were found. Reliability of the fleet was kept at an acceptable level compared to the reference in-house maintenance (≥90%) while an increase in the Mean Time Between Failure was observed. Conclusions: For the purposes of a small company, the method can address the choice of outsourcing maintenance as the best. Finally, a general trend is then extrapolated from the analysis performed, in order to constitute a decision guideline. The research can benefit from further analysis to test and validate that the selected approach is effective from the perspective of transport operator. Full article
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9 pages, 235 KiB  
Article
Grounding Intelligibility, Safeguarding Mystery: A Neoclassical Reading of Ernan McMullin’s Legacy
by Amerigo Barzaghi
Religions 2024, 15(5), 625; https://doi.org/10.3390/rel15050625 (registering DOI) - 20 May 2024
Abstract
This paper suggests a “neoclassical” reading of Ernan McMullin’s thought on science and theology. McMullin’s Augustinian convictions on God and the God–world relation coincide with those of some prominent scholars from two renowned schools of neo-scholastic philosophy of the twentieth century in Louvain [...] Read more.
This paper suggests a “neoclassical” reading of Ernan McMullin’s thought on science and theology. McMullin’s Augustinian convictions on God and the God–world relation coincide with those of some prominent scholars from two renowned schools of neo-scholastic philosophy of the twentieth century in Louvain and Milan. The school of Milan, thanks to the work of some disciples of its leading figure, Amato Masnovo, developed a neoclassical version of neo-scholasticism, articulating a fundamental theory of knowledge, as well as an essential, rigorous path to God. We recall the main tenets of a neoclassical path to God, and we interpret this path as a possible contribution to the science–theology dialogue, in line with McMullin’s Augustinism. A neoclassical approach to science and theology, with its rediscovery and reactualization of some ideas of classic philosophy in an interdisciplinary context, grounds the intelligibility of the universe and safeguards its mystery. Full article
17 pages, 5988 KiB  
Article
Optimizing Active Disturbance Rejection Control for a Stubble Breaking and Obstacle Avoiding Control System
by Huibin Zhu, Tao Huang, Lizhen Bai and Wenkai Zhang
Agriculture 2024, 14(5), 786; https://doi.org/10.3390/agriculture14050786 (registering DOI) - 20 May 2024
Abstract
In order to improve the obstacle avoidance control performance and anti-interference ability of a stubble breaking device of a no-tillage planter, a back-propagation neural network (BPNN)-optimized fuzzy active disturbance rejection control (ADRC) controller was designed to optimize the control performance of a servo [...] Read more.
In order to improve the obstacle avoidance control performance and anti-interference ability of a stubble breaking device of a no-tillage planter, a back-propagation neural network (BPNN)-optimized fuzzy active disturbance rejection control (ADRC) controller was designed to optimize the control performance of a servo motor. Firstly, a negative feedback mathematical model was established for the obstacle avoidance control system. Then, the nonlinear state error feedback (NLSEF) parameters in the fuzzy ADRC were intelligently optimized by the BPNN algorithm. In this way, a fuzzy ADRC controller based on BPNN optimization was formed to optimize the control process of a servo motor. Matlab/Simulink (R2022b) was used to complete the simulation model design and parameter adjustment. Consequently, the response time was 0.089 s using the BPNN fuzzy ADRC controller, which was shorter than the 0.303 s of the ADRC controller and the 0.100 s of the fuzzy ADRC controller. The overshoot was 0.1% using a BPNN fuzzy ADRC controller, which was less than the 2% of the ADRC controller and the 1% of the fuzzy ADRC controller. After noise signal interference was introduced into the control system, the regression steady state time of the BPNN fuzzy ADRC controller was 0.22 s, which was shorter than the 0.56 s of the ADRC controller and the 0.45 s of the fuzzy ADRC controller. A hardware-in-the-loop simulation experimental platform of the obstacle avoidance control system was constructed. The experiment results show that the servo motor control system has a fast dynamic response, small steady-state error and strong anti-interference ability for obstacle avoidance at the target height. Then, the control system error was within the allowable range. The servo motor control effect of the BPNN fuzzy ADRC was better than the ADRC and fuzzy ADRC. This optimized servo motor control method can provide a reference for improving the obstacle avoidance control effect problem of no-tillage seeders in stubble breaking operations on rocky desertification areas. Full article
(This article belongs to the Section Agricultural Technology)
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28 pages, 5849 KiB  
Article
TSANN-TG: Temporal–Spatial Attention Neural Networks with Task-Specific Graph for EEG Emotion Recognition
by Chao Jiang, Yingying Dai, Yunheng Ding, Xi Chen, Yingjie Li and Yingying Tang
Brain Sci. 2024, 14(5), 516; https://doi.org/10.3390/brainsci14050516 - 20 May 2024
Abstract
Electroencephalography (EEG)-based emotion recognition is increasingly pivotal in the realm of affective brain–computer interfaces. In this paper, we propose TSANN-TG (temporal–spatial attention neural network with a task-specific graph), a novel neural network architecture tailored for enhancing feature extraction and effectively integrating temporal–spatial features. [...] Read more.
Electroencephalography (EEG)-based emotion recognition is increasingly pivotal in the realm of affective brain–computer interfaces. In this paper, we propose TSANN-TG (temporal–spatial attention neural network with a task-specific graph), a novel neural network architecture tailored for enhancing feature extraction and effectively integrating temporal–spatial features. TSANN-TG comprises three primary components: a node-feature-encoding-and-adjacency-matrices-construction block, a graph-aggregation block, and a graph-feature-fusion-and-classification block. Leveraging the distinct temporal scales of features from EEG signals, TSANN-TG incorporates attention mechanisms for efficient feature extraction. By constructing task-specific adjacency matrices, the graph convolutional network with an attention mechanism captures the dynamic changes in dependency information between EEG channels. Additionally, TSANN-TG emphasizes feature integration at multiple levels, leading to improved performance in emotion-recognition tasks. Our proposed TSANN-TG is applied to both our FTEHD dataset and the publicly available DEAP dataset. Comparative experiments and ablation studies highlight the excellent recognition results achieved. Compared to the baseline algorithms, TSANN-TG demonstrates significant enhancements in accuracy and F1 score on the two benchmark datasets for four types of cognitive tasks. These results underscore the significant potential of the TSANN-TG method to advance EEG-based emotion recognition. Full article
(This article belongs to the Special Issue Neural Network in Computational Neuroscience)
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20 pages, 1743 KiB  
Review
The Therapeutic Potential of Harpagophytum procumbens and Turnera subulata and Advances in Nutraceutical Delivery Systems in Neurodegenerative Diseases
by Antonio Carlos Vital Júnior, Mikaelly Batista da Silva, Shênia Santos Monteiro and Matheus Augusto de Bittencourt Pasquali
Pharmaceuticals 2024, 17(5), 660; https://doi.org/10.3390/ph17050660 (registering DOI) - 20 May 2024
Abstract
This review article covers the therapeutic potential of the plants Harpagophytum procumbens and Turnera subulata in the treatment of neurodegenerative diseases. Despite the recognition of their beneficial properties, there is notable shortage of specific clinical and in vitro studies on these species regarding [...] Read more.
This review article covers the therapeutic potential of the plants Harpagophytum procumbens and Turnera subulata in the treatment of neurodegenerative diseases. Despite the recognition of their beneficial properties, there is notable shortage of specific clinical and in vitro studies on these species regarding neurodegenerative diseases. Compounds such as harpagosides and vite-xin-2-O-rhamnoside, found in Harpagophytum procumbens and Turnera subulata, respectively, as well as other antioxidants and anti-inflammatory agents, are associated with mechanisms of action that involve reducing oxidative stress and modulating the inflammatory response, indicating their therapeutic potential in these pathologies. Additionally, the use of nutraceuticals derived from medicinal plants has emerged as a promising approach, offering natural therapeutic alternatives. However, the pressing need for studies focusing on the pharmacokinetics, safety, and pharmacological interactions of these extracts for the treatment of neurodegenerative diseases is emphasized. This review also evaluated advances in nutraceutical delivery systems, highlighting technological innovations that can optimize the precise delivery of these compounds to patients. Such findings highlight the gaps in the study of these plants for the treatment of neurodegenerative diseases and, at the same time, the potential for opening new perspectives in the treatment of neurodegenerative diseases, providing expectations for innovative solutions in this critical domain of medicine. Full article
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10 pages, 1664 KiB  
Article
Osteocalcin: A Potential Marker of Peripheral Arterial Stiffness in Hypertensive Patients
by Yung-Hsuan Wang, Chien-Hao Hsiao, Ji-Hung Wang and Bang-Gee Hsu
Medicina 2024, 60(5), 835; https://doi.org/10.3390/medicina60050835 (registering DOI) - 20 May 2024
Abstract
Background and Objectives: Brachial–ankle pulse wave velocity (baPWV) is an established independent risk factor for cardiovascular events, cardiovascular mortality, and all-cause mortality. Osteocalcin (OC) is recognized to be associated with vascular function. The present study assessed the correlation between serum OC levels [...] Read more.
Background and Objectives: Brachial–ankle pulse wave velocity (baPWV) is an established independent risk factor for cardiovascular events, cardiovascular mortality, and all-cause mortality. Osteocalcin (OC) is recognized to be associated with vascular function. The present study assessed the correlation between serum OC levels and peripheral arterial stiffness (PAS) measured through baPWV in hypertensive patients. Materials and Methods: Fasting blood samples were collected from 120 hypertensive participants. The serum total OC levels were measured using a commercial enzyme-linked immunosorbent assay kit, whereas the baPWV device was used to detect PAS. The PAS group had left or right baPWV > 18.0 m/s. Results: Among the hypertensive patients, 24 (20.0%) were classified into the PAS group. The PAS group exhibited a significantly older age (p = 0.011), higher prevalence of diabetes (p = 0.010), systolic blood pressure (p = 0.019), levels of serum fasting glucose (p = 0.003), blood urea nitrogen (p = 0.024), creatinine (p = 0.004), C-reactive protein (p = 0.007), OC (p = 0.002), and lower estimated glomerular filtration rate (p = 0.004) than the non-PAS group. Age (odds ratio [OR]: 1.076, 95% CI: 1.004–1.153, p = 0.037) and serum OC level (OR: 1.797, 95% confidence interval (CI): 1.077–3.000, p = 0.025) were independent factors linked to PAS in hypertensive patients in the multivariate logistic regression analysis. Conclusions: Serum OC levels and older age are positively associated with PAS in hypertensive patients. Full article
(This article belongs to the Section Urology & Nephrology)
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20 pages, 4703 KiB  
Article
Investigation of Carbon Fiber Reinforced Polymer Concrete Reinforcement Ageing Using Microwave Infrared Thermography Method
by Barbara Szymanik, Sam Ang Keo, Franck Brachelet and Didier Defer
Appl. Sci. 2024, 14(10), 4331; https://doi.org/10.3390/app14104331 - 20 May 2024
Abstract
This study presents the utilization of the microwave infrared thermography (MIRT) technique to identify and analyze the defects in the carbon-fiber-reinforced polymer (CFRP) composite reinforcement of concrete specimens. At first, a set of numerical models was created, comprising the broadband pyramidal horn antenna [...] Read more.
This study presents the utilization of the microwave infrared thermography (MIRT) technique to identify and analyze the defects in the carbon-fiber-reinforced polymer (CFRP) composite reinforcement of concrete specimens. At first, a set of numerical models was created, comprising the broadband pyramidal horn antenna and the analyzed specimen. The utilization of the system operating at a power of 1000 W in a continuous mode, operating at frequency of 2.45 GHz, was analyzed. The specimen under examination comprised a compact concrete slab that was covered with an adhesive layer and, thereafter, topped with a layer of CFRP. An air gap represented a defect at the interface between the concrete and the CFRP within the adhesive layer. In the modeling stage, the study investigated three separate scenarios—a sample with no defects, a sample with a defect located at the center, and a sample with a numerous additional random defects located at the rim of the CFRP matte—to analyze the effect of the natural reinforcement degradation in this area. The next phase of the study involved conducting experiments to confirm the results obtained from numerical modeling. In the experiments, the concrete sample aged for 10 years with the defect in the center and naturally developed defects at the CFRP rim was used. The study employed numerical modeling to explore the phenomenon of microwave heating in complex structures. The aim was to assess the chosen antenna design and identify the most effective experimental setup. These conclusions were subsequently confirmed through experimentation. The observations made during the heating process were particularly remarkable since they deviated from earlier studies that solely conducted measurements of the sample post-heating phase. The findings demonstrate that MIRT has the capacity to be employed as a technique for detecting flaws in concrete structures reinforced with CFRP. Full article
16 pages, 311 KiB  
Article
Novel Estimations of Hadamard-Type Integral Inequalities for Raina’s Fractional Operators
by Merve Coşkun, Çetin Yildiz and Luminiţa-Ioana Cotîrlă
Fractal Fract. 2024, 8(5), 302; https://doi.org/10.3390/fractalfract8050302 - 20 May 2024
Abstract
In the present paper, utilizing a wide class of fractional integral operators (namely the Raina fractional operator), we develop novel fractional integral inequalities of the Hermite–Hadamard type. With the help of the well-known Riemann–Liouville fractional operators, s-type convex functions are derived using [...] Read more.
In the present paper, utilizing a wide class of fractional integral operators (namely the Raina fractional operator), we develop novel fractional integral inequalities of the Hermite–Hadamard type. With the help of the well-known Riemann–Liouville fractional operators, s-type convex functions are derived using the important results. We also note that some of the conclusions of this study are more reasonable than those found under certain specific conditions, e.g., s=1, λ=α, σ(0)=1, and w=0. In conclusion, the methodology described in this article is expected to stimulate further research in this area. Full article
(This article belongs to the Special Issue Fractional Integral Inequalities and Applications, 2nd Edition)
32 pages, 18049 KiB  
Article
The Challenges of Blood Sample Delivery via Drones in Urban Environment: A Feasibility Study through Specific Operation Risk Assessment Methodology
by Sara Molinari, Riccardo Patriarca and Marco Ducci
Drones 2024, 8(5), 210; https://doi.org/10.3390/drones8050210 - 20 May 2024
Abstract
In recent years, Unmanned Aircraft System (UAS) usage in the medical sector as an alternative to traditional means of goods transport has grown significantly. Even though the reduced response time achieved with UASs can be lifesaving in critical situations, their usage must comply [...] Read more.
In recent years, Unmanned Aircraft System (UAS) usage in the medical sector as an alternative to traditional means of goods transport has grown significantly. Even though the reduced response time achieved with UASs can be lifesaving in critical situations, their usage must comply with technological constraints such as range, speed and capacity, while minimizing potential risks. In this paper, the feasibility of a drone operation dedicated to the transport of blood samples in an urban area is studied through a safety risk analysis. The assessment utilizes the Specific Operation Risk Assessment (SORA) framework, in line with current European regulations, and extends it to define flight trajectories with minimal risk. A case study in the Helsinki urban area is used as a reference, with an exemplary case of commercial drone transportation of blood samples between the Töölö and Malmi Hospitals. By leveraging the drone performance capabilities and minimizing the risk for people on the ground, this approach demonstrates that medical delivery using drones in densely populated urban environments remains challenging. Nonetheless, it argues that the proposed method can enhance risk awareness and support the planning of feasible operations. Full article
(This article belongs to the Special Issue Flight Control and Collision Avoidance of UAVs)
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22 pages, 299 KiB  
Article
An International Data-Based Systems Agency IDA: Striving for a Peaceful, Sustainable, and Human Rights-Based Future
by Peter G. Kirchschlaeger
Philosophies 2024, 9(3), 73; https://doi.org/10.3390/philosophies9030073 - 20 May 2024
Abstract
Digital transformation and “artificial intelligence (AI)”—which can more adequately be called “data-based systems (DS)”—comprise ethical opportunities and risks. Therefore, it is necessary to identify precisely ethical opportunities and risks in order to be able to benefit sustainably from the opportunities and to master [...] Read more.
Digital transformation and “artificial intelligence (AI)”—which can more adequately be called “data-based systems (DS)”—comprise ethical opportunities and risks. Therefore, it is necessary to identify precisely ethical opportunities and risks in order to be able to benefit sustainably from the opportunities and to master the risks. The UN General Assembly has recently adopted a resolution aiming for ‘safe, secure and trustworthy artificial intelligence systems’. It is now urgent to implement and build on the UN General Assembly Resolution. Allowing humans and the planet to flourish sustainably in peace and guaranteeing globally that human dignity is respected not only offline but also online, in the digital sphere, and in the domain of DS, requires two policy measures: (1) human rights-based data-based systems (HRBDS): HRBDS means that human rights serve as the basis of digital transformation and DS. (2) International Data-Based Systems Agency (IDA): IDA should be established at the UN as a platform for cooperation in the field of digital transformation and DS, fostering human rights, security, and peaceful uses of DS, as well as a global supervisory institution and regulatory authority in digital transformation and DS. The establishment of IDA is realistic because humanity has already shown in its past that we are able to not always “blindly” pursue the technically possible but also to limit ourselves to what is technically feasible when humanity and the planet are at stake. For instance, humans researched the field of nuclear technology, developed the atomic bomb, and detonated it several times. Nonetheless, the same humans limited research and development in the field of nuclear technology to prevent even worse consequences by establishing the International Atomic Energy Agency (IAEA) at the UN. Full article
(This article belongs to the Special Issue The Ethics of Modern and Emerging Technology)
33 pages, 46215 KiB  
Article
The Necessity and Goodness of Animals in Sijistānī’s Kashf Al-Maḥjūb
by Peter Adamson and Hanif Amin Beidokhti
Philosophies 2024, 9(3), 72; https://doi.org/10.3390/philosophies9030072 - 20 May 2024
Abstract
The Neoplatonic notion of “emanation” implies a required progression through hierarchical stages, originating from the highest principle (the One or God) and cascading down through a series of principles. While this process is deemed necessary, it is also inherently good, even “choiceworthy”, aligning [...] Read more.
The Neoplatonic notion of “emanation” implies a required progression through hierarchical stages, originating from the highest principle (the One or God) and cascading down through a series of principles. While this process is deemed necessary, it is also inherently good, even “choiceworthy”, aligning with the identification of the first principle with the Good. Plotinus, a prominent Neoplatonist, emphasizes the beauty and goodness of the sensible world, governed by divine providence. This perspective, transmitted through Arabic adaptations of Plotinus, influences Islamic philosophers too. This paper delves into the thought of the Ismāʿīlī philosopher Abū Yaʿqūb al-Sijistānī (d. after. 349/971), exploring the interplay of necessity and goodness in his cosmology, with a focus on non-human animals. Sijistānī’s Persian Uncovering the Veiled provides a unique perspective on animals, presenting them as both necessary unfoldings of the universal intellect and inherently good beings with intrinsic value. The paper concludes with an appendix featuring an improved edition and English translation of relevant passages. Full article
(This article belongs to the Special Issue Ancient and Medieval Theories of Soul)
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15 pages, 257 KiB  
Article
Making the Memory Book: War-Time Loss and Memorialization through Ephemera
by Bruce Scates
Genealogy 2024, 8(2), 64; https://doi.org/10.3390/genealogy8020064 - 20 May 2024
Abstract
This article explores the way a family fashioned a memorial to a son ‘taken by the war’. It focuses on the Robert’s collection in Melbourne, Australia’s largest bound collection of war time ephemera, and the making of what was called ‘Frank’s Memory Book’. [...] Read more.
This article explores the way a family fashioned a memorial to a son ‘taken by the war’. It focuses on the Robert’s collection in Melbourne, Australia’s largest bound collection of war time ephemera, and the making of what was called ‘Frank’s Memory Book’. It argues that families asserted ownership over their dead, crafting different modes of memorialization to authorized modes of remembrance, considers the way communities of mourners were brought together and highlights tensions between private loss and public memory. The making of ephemera is examined at length as is the part material culture plays in libraries and archives. Full article
16 pages, 240 KiB  
Article
Adoption in the Era of Secrecy: Practical and Ethical Challenges Facing Adult Adoptees in the Search for Birth Families
by Patricia Robinson
Genealogy 2024, 8(2), 63; https://doi.org/10.3390/genealogy8020063 - 20 May 2024
Abstract
This article explores findings from research into the impact of adoption throughout the life course of adults who were adopted in the era of secrecy, the 1940s–1970s. A narrative approach was used to explore their reflections, and semi-structured interviews were undertaken with 11 [...] Read more.
This article explores findings from research into the impact of adoption throughout the life course of adults who were adopted in the era of secrecy, the 1940s–1970s. A narrative approach was used to explore their reflections, and semi-structured interviews were undertaken with 11 adults. The findings were then analysed through the lens of the Life Course Perspective. Previous studies on adoption have largely explored the outcomes of searching for birth family members, but few have focused on how adoptees went about this, the challenges they encountered, the decisions made and what happened as they began to dismantle layers of secrecy surrounding their adoption. For most of the participants, resources such as genealogical websites and particular guidance were not available at the time they were searching for birth information or attempting to make contact with birth families. Their accounts highlighted how social workers with potential birth information did not appear to be able to consider the broader emotional impact this might entail for adoptees. Initial meetings were described by some adoptees as hurdles to be overcome, and little birth information was given. Some continued to search for birth relatives without support, using random methods to gain contact. The ways in which adults went about their search sometimes appeared to suggest a lack of consideration or awareness on their part of the possible impact on others involved. In reality, they were faced with obstacles and barriers as they attempted to learn about their origins. Their stories provide a valuable insight into how adult adoptees sought to dismantle layers of secrecy, highlighting the complex, challenging and isolated situation they found themselves in as they searched for birth information and birth families, as well as the ethical challenges and dilemmas they had to negotiate in order to do so. Full article
(This article belongs to the Special Issue Ethics and Family History: Challenges, Dilemmas and Responsibilities)
14 pages, 1413 KiB  
Article
Genetic Mapping for Leaf Shape and Leaf Size in Non-Heading Chinese Cabbage by a RIL Population
by Tianzi Zhao, Aimei Bai, Xinya Wang, Feixue Zhang, Miaomiao Yang, Yuhui Wang, Tongkun Liu, Xilin Hou and Ying Li
Horticulturae 2024, 10(5), 529; https://doi.org/10.3390/horticulturae10050529 - 20 May 2024
Abstract
Leaves are the predominant photosynthetic and edible organs in non-heading Chinese cabbage (Brassica campestris ssp. chinensis, NHCC), contributing significantly to yield, appearance, and desirability to consumers. However, the genetic basis of leaf shape and size in non-heading Chinese cabbage remains unclear. [...] Read more.
Leaves are the predominant photosynthetic and edible organs in non-heading Chinese cabbage (Brassica campestris ssp. chinensis, NHCC), contributing significantly to yield, appearance, and desirability to consumers. However, the genetic basis of leaf shape and size in non-heading Chinese cabbage remains unclear. In this study, we developed a RIL population using ‘Maertou’, with slender leaves and narrow petioles, and ‘Suzhouqing’, with oval leaves and wide petioles, to construct a genetic linkage map and detect QTLs. To obtain stable and reliable QTLs, the 11 leaf-related traits, including the leaf length, leaf width, and fresh weight of the lamina and petiole and the thickness of petiole was observed on two locations—while the leaf shape, petiole shape, index of lamina/petiole length, and index of petiole fresh weight were calculated based on 7 leaf-related traits. QTL mapping illustrated that a total of 27 QTLs for leaf-related traits were preliminarily detected. The candidate genes were annotated and several genes involved in leaf development and leaf shape appeared in the overlapping regions of multiple loci, such as KRP2, GRF4, ARGOS, and SAUR9. This study lays the foundation for further exploration of the genetic mechanisms and development of effective molecular markers for leaf shape and size in NHCC. Full article
(This article belongs to the Section Vegetable Production Systems)
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24 pages, 3846 KiB  
Article
Insights into Medieval Grape Cultivation in Al-Andalus: Morphometric, Domestication, and Multivariate Analysis of Vitis vinifera Seed Types
by Javier Valera, Diego Rivera, Gonzalo Matilla-Séiquer, Diego José Rivera-Obón, Carlos-Alvar Ocete, Rafael Ocete, Julio Navarro, Pedro Jiménez, Rafael González, Juan Antonio Ramírez, José María Moreno, José Javier Martínez and Concepción Obón
Horticulturae 2024, 10(5), 530; https://doi.org/10.3390/horticulturae10050530 - 20 May 2024
Abstract
Understanding the origins and evolution of modern grapevine varieties in the Iberian Peninsula and western Europe necessitates an examination of the proportions of Vitis vinifera cultivars, their relationships with wild grapevine populations, and the utilization of seedless cultivars in al-Andalus. Employing morphometric studies, [...] Read more.
Understanding the origins and evolution of modern grapevine varieties in the Iberian Peninsula and western Europe necessitates an examination of the proportions of Vitis vinifera cultivars, their relationships with wild grapevine populations, and the utilization of seedless cultivars in al-Andalus. Employing morphometric studies, domestication indices, multivariate analysis, and Bayesian hypothesis testing, this study investigates several distinct seed types identified in materials from Roman and medieval deposits. These seeds exhibit a spectrum from highly domesticated to purely wild. Our findings reveal the predominance of Proles Occidentalis Negrul, and the presence of feral-like grapevines associated with Proles Euphratica. Additionally, we observe the continuous presence of wild grapevines related to Vitis sylvestris CC Gmelin throughout the studied period. Seeds exhibiting intermediate characteristics are documented, alongside the identification of “stenosperms”, suggesting anomalies in seed formation. Notably, the presence of Vitis vinifera raisins “stenospermocarpics” of the sultana type is suggested, potentially elucidating the absence of table grapes and raisins of the Proles Orientalis Negrul in the archaeological record, despite frequent mentions by medieval agronomy writers from al-Andalus. Full article
(This article belongs to the Section Viticulture)
14 pages, 1673 KiB  
Article
Effect of Menthol Treatment on the Sprouting and Quality of Potato Tuber
by Ye Xu, Yang Qin, Qianqian Hou, Defu Niu and Qingmin Chen
Horticulturae 2024, 10(5), 528; https://doi.org/10.3390/horticulturae10050528 - 20 May 2024
Abstract
This study used Dutch potatoes at the end of dormancy as a material to explore the impact of menthol (0.2 and 0.5 g/kg based on potato mass) treatment on sprouting inhibition and potato quality. The findings revealed that a menthol concentration of 0.5 [...] Read more.
This study used Dutch potatoes at the end of dormancy as a material to explore the impact of menthol (0.2 and 0.5 g/kg based on potato mass) treatment on sprouting inhibition and potato quality. The findings revealed that a menthol concentration of 0.5 g/kg effectively inhibited potato tuber sprouting and significantly reduced glucoside alkaloid production. After a storage period of 15 days, the sprouting percentage and glucoside alkaloid content of potatoes treated with 0.5 g/kg menthol were observed to be significantly lower at 4.17% and 68.63 mg/kg, respectively, compared to the control group which exhibited values of 100% and 282.01 mg/kg, respectively (p < 0.05). Throughout the storage period, 0.5 g/kg of menthol promoted respiration, reduced malondialdehyde production in potatoes, inhibited polyphenol oxidase activity, and slowed down tissue browning. Additionally, it mitigated the decline in starch and soluble protein content, inhibiting the accumulation of reducing sugars. Full article
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16 pages, 1159 KiB  
Article
Bigel Matrix Loaded with Probiotic Bacteria and Prebiotic Dietary Fibers from Berry Pomace Suitable for the Development of Probiotic Butter Spread Product
by Laura Tamašauskaitė, Vidmantė Minelgaitė, Aušra Šipailienė, Rimantė Vinauskienė, Viktorija Eisinaitė and Daiva Leskauskaitė
Gels 2024, 10(5), 349; https://doi.org/10.3390/gels10050349 - 20 May 2024
Abstract
This study presents a novel approach to developing a probiotic butter spread product. We evaluated the prebiotic activity of soluble dietary fibers extracted from cranberry and sea buckthorn berry pomace with different probiotic strains (Limosilactobacillus reuteri, Lacticaseibacillus paracasei, and Lactiplantibacillus [...] Read more.
This study presents a novel approach to developing a probiotic butter spread product. We evaluated the prebiotic activity of soluble dietary fibers extracted from cranberry and sea buckthorn berry pomace with different probiotic strains (Limosilactobacillus reuteri, Lacticaseibacillus paracasei, and Lactiplantibacillus plantarum), uploaded selected compatible combination in the bigel matrix, and applied it in the probiotic butter spread formulation. Bigels and products were characterized by physical stability, rheological, textural properties, and viability of probiotics during storage at different conditions. The highest prebiotic activity score was observed in soluble cranberry (1.214 ± 0.029) and sea buckthorn (1.035 ± 0.009) fibers when cultivated with L. reuteri. The bigels loaded with probiotics and prebiotic fiber exhibited a significant increase in viscosity (higher consistency coefficient 40–45 Pa·sn) and better probiotic viability (>6 log CFU/g) during long-term storage at +4 °C temperature, surpassing the bigels loaded with probiotics alone. Bigels stored at a lower temperature (−18 °C) maintained high bacterial viability (above 8.5 log CFU/g). The butter spread enriched with the bigel matrix was softer (7.6–14.2 N), indicating improved spreadability. The butter spread product consistently met the required 6 log CFU/g for a functional probiotic food product until 60 days of storage at +4 °C temperature. The butter stored at −18 °C remained probiotic throughout the entire storage period, confirming the protective effect of the bigel matrix. The study’s results showed the potential of the bigel to co-encapsulate, protect, and deliver probiotics during prolonged storage under different conditions. Full article
(This article belongs to the Special Issue Recent Advances in Food Gels)
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18 pages, 409 KiB  
Article
Financial Literacy: A Case Study for Portugal
by Luís Almeida, João Chanoca and Fernando Tavares
J. Risk Financial Manag. 2024, 17(5), 215; https://doi.org/10.3390/jrfm17050215 - 20 May 2024
Abstract
This work aims at understanding the level of financial literacy in Portugal, identifying the determinants of financial literacy in the Portuguese population, taking as an example certain sociodemographic factors such as gender and age. The aim is to understand whether there is a [...] Read more.
This work aims at understanding the level of financial literacy in Portugal, identifying the determinants of financial literacy in the Portuguese population, taking as an example certain sociodemographic factors such as gender and age. The aim is to understand whether there is a high level of adherence to financial literacy programs and initiatives, as well as the impact of financial knowledge variables on the financial literacy of the Portuguese population. The methodology used was quantitative and based on a questionnaire survey. The sample consisted of 600 individuals, all over 18 years old. It was concluded that individuals in the 26 to 35 age group had the best knowledge and that this sample showed better knowledge of interest rates compared to inflation and risk. The exploratory factor analysis shows five factors that determine the financial literacy of the Portuguese population and the way they manage their finances, which are (1) the perception of their current financial situation; (2) planning and controlling personal finances; (3) the perception of risky financial assets; (4) the perception of risk-free financial assets; and (5) savings. This research contributes to expanding scientific understanding in the field of financial literacy and offering support to the review of financial education policies by formulators, aiming to develop tools that help improve the financial behavior of the Portuguese population. Full article
(This article belongs to the Section Financial Markets)
12 pages, 234 KiB  
Article
Impact of Pain on Activities of Daily Living in Older Adults: A Cross-Sectional Analysis of Korean Longitudinal Study of Aging (KLoSA)
by Ambrish Singh, Sreelatha Akkala, Minakshi Nayak, Anirudh Kotlo, Naresh Poondla, Syed Raza, Jim Stankovich and Benny Antony
Geriatrics 2024, 9(3), 65; https://doi.org/10.3390/geriatrics9030065 - 20 May 2024
Abstract
Pain, particularly musculoskeletal (MSK) and multi-site pain, significantly impacts activities of daily living (ADL) in the elderly, leading to a decline in overall quality of life (QoL). This study, comprising 7490 participants, (mean age: 69 ± 10; females: 57%) from the sixth wave [...] Read more.
Pain, particularly musculoskeletal (MSK) and multi-site pain, significantly impacts activities of daily living (ADL) in the elderly, leading to a decline in overall quality of life (QoL). This study, comprising 7490 participants, (mean age: 69 ± 10; females: 57%) from the sixth wave of the Korean Longitudinal Study of Aging (KLoSA), aimed to assess the association between self-reported pain and ADL impairment among the elderly population. Notably, 62% of participants reported experiencing pain, with back pain being the most prevalent (36%) and stomachache the least (0.39%). A majority (61%) of individuals reported MSK-related pain. Additionally, 20% reported pain at one site and 0.03% experienced pain at 12 sites. ADL impairment was observed in 376 (5.0%) participants. Compared to those without pain, participants reporting moderate and severe pain had higher odds of ADL impairment [2.31 (95% CI, 1.66–3.21) and 2.98 (95% CI, 1.95–4.53), respectively]. Pain experienced in the shoulder, arm, wrist, back, hip, leg, and ankle had a significant association with ADL impairment, with ORs ranging from 2.66 (95% CI, 1.80–3.93; hip pain) to 1.36 (95% CI 1.07–1.72; back pain). Furthermore, multi-site pain was associated with higher ADL impairment [1–6 sites: OR: 1.49 (95% CI, 1.11–2.01); 7–12 sites: OR: 7.16 (95% CI, 3.60–14.26)]. These findings underscore the importance of addressing MSK and multi-site pain through targeted interventions, potentially enhancing ADL and contributing to an improved QoL among the elderly population. Full article
(This article belongs to the Section Geriatric Rheumatology)
18 pages, 556 KiB  
Article
South African Real Estate Investment Trusts Prefer Tuesdays
by Oluwaseun Damilola Ajayi and Emmanuel Kofi Gavu
J. Risk Financial Manag. 2024, 17(5), 214; https://doi.org/10.3390/jrfm17050214 - 20 May 2024
Abstract
This study examines the day-of-the-week effect on the returns of different classifications of South African REITs. Ordinary least squares regression (OLS), generalized autoregressive conditional heteroskedasticity (GARCH) (1,1) (2,1), and Kruskal–Wallis (KW) tests were performed on data obtained from the IRESS Expert database from [...] Read more.
This study examines the day-of-the-week effect on the returns of different classifications of South African REITs. Ordinary least squares regression (OLS), generalized autoregressive conditional heteroskedasticity (GARCH) (1,1) (2,1), and Kruskal–Wallis (KW) tests were performed on data obtained from the IRESS Expert database from 2013 to 2021. We found statistical differences in the day-of-the-week effects for SAREITs; the best day to invest in office REITs is Friday, for diversified REITs Thursday, and for industrial REITs Friday. Generally, Wednesday was found to be the least profitable day to invest in all REIT classifications because it had the least average daily return. Tuesdays were the most profitable days for all REIT classifications, with the highest average daily return. REITs traded the most on Fridays, while REITs traded the least on Mondays. Returns were the most volatile on Monday, while volume was the least volatile on Thursday. The KW test revealed a statistically significant difference between the median returns across days of the week. Based on the above, profitability is expressed on Tuesdays in South African REITs. By recognizing the day-of-the-week effect, investors can buy and sell South African REITs more effectively. This study, apart from being the first in the context of South African REITs, provides updated evidence of the contested calendar anomaly issues. Full article
(This article belongs to the Section Financial Markets)
21 pages, 3708 KiB  
Review
A Systematic Review of Social Sustainability Indicators for Water Use along the Agricultural Value Chain
by Pascalina Matohlang Pilane, Henry Jordaan and Yonas T. Bahta
Hydrology 2024, 11(5), 72; https://doi.org/10.3390/hydrology11050072 - 20 May 2024
Abstract
The concept of sustainable water use serves as an indicator of environmental, economic, and social pressure on freshwater resources globally; however, the social element of sustainability is not well researched within water-consumption studies. The objective of this paper is to consider the current [...] Read more.
The concept of sustainable water use serves as an indicator of environmental, economic, and social pressure on freshwater resources globally; however, the social element of sustainability is not well researched within water-consumption studies. The objective of this paper is to consider the current state of the literature on social sustainability indicators for water use in agriculture, as well as to describe the social (people) element of sustainability and establish water use as an element of society. By combining viewpoints, systematic literature reviews address research topics with a strength that no single work can have. From 314 papers published between 2013 and 2023, 42 papers were eligible for the review. This work employed a mixed-methods approach that included a systematic review following the (PRISMA) framework, scientific mapping through VOSviewer software (version 1.6.19), thematic reviews, and a review of the grey literature retrieved from artificial intelligence and deep learning technologies. The findings indicate that social sustainability indicators are based on environmental indicators. There are no set standards for what to consider as a social indicator of water use or for how these indictors can be measured. Life-cycle assessment and water-footprint assessment frameworks have shown progress with indicators that capture the social value of water such as productivity-reducing externalities, equity, and jobs per cubic metre of water. Full article
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27 pages, 1903 KiB  
Article
Comparative Biomechanical Stability of the Fixation of Different Miniplates in Restorative Laminoplasty after Laminectomy: A Finite Element Study
by Guoyin Liu, Weiqian Huang, Nannan Leng, Peng He, Xin Li, Muliang Lin, Zhonghua Lian, Yong Wang, Jianmin Chen and Weihua Cai
Bioengineering 2024, 11(5), 519; https://doi.org/10.3390/bioengineering11050519 - 20 May 2024
Abstract
A novel H-shaped miniplate (HSM) was specifically designed for restorative laminoplasties to restore patients’ posterior elements after laminectomies. A validated finite element (FE) model of L2/4 was utilized to create a laminectomy model, as well as three restorative laminoplasty models based on the [...] Read more.
A novel H-shaped miniplate (HSM) was specifically designed for restorative laminoplasties to restore patients’ posterior elements after laminectomies. A validated finite element (FE) model of L2/4 was utilized to create a laminectomy model, as well as three restorative laminoplasty models based on the fixation of different miniplates after a laminectomy (the RL-HSM model, the RL-LSM model, and the RL-THM model). The biomechanical effects of motion and displacement on a laminectomy and restorative laminoplasty with three different shapes for the fixation of miniplates were compared under the same mechanical conditions. This study aimed to validate the biomechanical stability, efficacy, and feasibility of a restorative laminoplasty with the fixation of miniplates post laminectomy. The laminectomy model demonstrated the greatest increase in motion and displacement, especially in axial rotation, followed by extension, flexion, and lateral bending. The restorative laminoplasty was exceptional in preserving the motion and displacement of surgical segments when compared to the intact state. This preservation was particularly evident in lateral bending and flexion/extension, with a slight maintenance efficacy observed in axial rotation. Compared to the laminectomy model, the restorative laminoplasties with the investigated miniplates demonstrated a motion-limiting effect for all directions and resulted in excellent stability levels under axial rotation and flexion/extension. The greatest reduction in motion and displacement was observed in the RL-HSM model, followed by the RL-LSM model and then the RL-THM model. When comparing the fixation of different miniplates in restorative laminoplasties, the HSMs were found to be superior to the LSMs and THMs in maintaining postoperative stability, particularly in axial rotation. The evidence suggests that a restorative laminoplasty with the fixation of miniplates is more effective than a conventional laminectomy due to the biomechanical effects of restoring posterior elements, which helps patients regain motion and limit load displacement responses in the spine after surgery, especially in axial rotation and flexion/extension. Additionally, our evaluation in this research study could benefit from further research and provide a methodological and modeling basis for the design and optimization of restorative laminoplasties. Full article
(This article belongs to the Special Issue Mechanobiology in Biomedical Engineering)

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