The 2023 MDPI Annual Report has
been released!
 
28 pages, 7647 KiB  
Article
Efficiency Assessment on Roof Geometry and Trombe Wall Shape for Improving Buildings’ Heating Performance
by Maher Dhahri, Ahmet Yüksel, Hana Aouinet, Di Wang, Müslüm Arıcı and Habib Sammouda
Buildings 2024, 14(5), 1297; https://doi.org/10.3390/buildings14051297 (registering DOI) - 04 May 2024
Abstract
It is crucial to consider structural design issues in Trombe wall (T-wall) buildings to promote more suitable indoor climates and thermal comfort standards. Therefore, the present study examined the impact of two different T-wall designs and six different roof types on the energy [...] Read more.
It is crucial to consider structural design issues in Trombe wall (T-wall) buildings to promote more suitable indoor climates and thermal comfort standards. Therefore, the present study examined the impact of two different T-wall designs and six different roof types on the energy and operational efficiency of a building located in a low-temperature and high-humidity winter climate. Ansys-CFX 15.0 software was employed to simulate the thermal and fluid dynamics behavior of the T-wall system, and flow, thermal comfort, energy, and exergy analyses were conducted. Three-dimensional simulation results and the pertinent literature data showed a good level of agreement, and the accuracy of the model was ensured. Outcomes revealed an average air velocity variation of 0.186 m/s and maximum average indoor air temperature variation of 3.3 °C between the six roof geometries. The highest air speed (0.988 m/s) was recorded for the gambrel roof while the lowest one (0.802 m/s) was recorded for the typical flat roof. The shed roof right with a rounded T-wall was more comfortable for standing and sitting activity than the others for the two T-wall shapes, and, at Y = 0.6 m and Y = 1.1 m, the average predicted percentages of dissatisfied (PPD) values were 31 and 28%, respectively. Furthermore, it was determined in the study that solar radiation intensity and T-wall and roof geometries had a significant effect on energy and exergy efficiency, and high energy and exergy efficiencies were achieved at higher solar intensity values. The best energy and exergy efficiencies were obtained for the butterfly and shed roof configurations. This study can serve as a reference for the thermal environment design of buildings with T-walls. Full article
(This article belongs to the Section Building Structures)
18 pages, 5270 KiB  
Article
Detracking Autoencoding Conditional Generative Adversarial Network: Improved Generative Adversarial Network Method for Tabular Missing Value Imputation
by Jingrui Liu, Zixin Duan, Xinkai Hu, Jingxuan Zhong and Yunfei Yin
Entropy 2024, 26(5), 402; https://doi.org/10.3390/e26050402 (registering DOI) - 04 May 2024
Abstract
Due to various reasons, such as limitations in data collection and interruptions in network transmission, gathered data often contain missing values. Existing state-of-the-art generative adversarial imputation methods face three main issues: limited applicability, neglect of latent categorical information that could reflect relationships among [...] Read more.
Due to various reasons, such as limitations in data collection and interruptions in network transmission, gathered data often contain missing values. Existing state-of-the-art generative adversarial imputation methods face three main issues: limited applicability, neglect of latent categorical information that could reflect relationships among samples, and an inability to balance local and global information. We propose a novel generative adversarial model named DTAE-CGAN that incorporates detracking autoencoding and conditional labels to address these issues. This enhances the network’s ability to learn inter-sample correlations and makes full use of all data information in incomplete datasets, rather than learning random noise. We conducted experiments on six real datasets of varying sizes, comparing our method with four classic imputation baselines. The results demonstrate that our proposed model consistently exhibited superior imputation accuracy. Full article
22 pages, 5089 KiB  
Article
Use of Recycled Plastic Fibers to Control Shrinkage and Desiccation Cracking in Clayey Soils
by Carolina Hernández, Gloria Beltrán and Eduardo Botero
Sustainability 2024, 16(9), 3853; https://doi.org/10.3390/su16093853 (registering DOI) - 04 May 2024
Abstract
Two main issues are addressed in this work. The first issue is environmental concerns about managing plastic waste on a large scale by promoting reuse with low energy requirements in the recycling processes. The second issue is the desiccation cracks in fine soils, [...] Read more.
Two main issues are addressed in this work. The first issue is environmental concerns about managing plastic waste on a large scale by promoting reuse with low energy requirements in the recycling processes. The second issue is the desiccation cracks in fine soils, induced by prolonged droughts, which have motivated the interest in mitigating the adverse effects on the stability of geotechnical works using recycled materials. Therefore, this work addresses a strategy based on the use of recycled polyethylene terephthalate (PET) and polypropylene (PP) fibers for the reinforcement of soils prone to cracking. To evaluate the effectiveness of plastic fibers in controlling soil volumetric changes and cracking during drying, several experiments were conducted in an environmental chamber to properly simulate and monitor the desiccation process. Image analysis and suction measurements provided several metrics and parameters, and their usefulness is discussed in detail, both for the unconventional determination of the optimum fiber content by weight with 100% effectiveness in preventing cracking and for correlating fiber content with reductions in shrinkage and cracking patterns, thus contributing to the understanding of the behavior of fiber-reinforced soils. Finally, examples of large-scale applications of recycled plastic fibers in geotechnical works are proposed, and the positive environmental impact is estimated. Full article
37 pages, 2323 KiB  
Review
Deciphering the Molecular Mechanisms behind Drug Resistance in Ovarian Cancer to Unlock Efficient Treatment Options
by Mariana Nunes, Carla Bartosch, Miguel Henriques Abreu, Alan Richardson, Raquel Almeida and Sara Ricardo
Cells 2024, 13(9), 786; https://doi.org/10.3390/cells13090786 (registering DOI) - 04 May 2024
Abstract
Ovarian cancer is a highly lethal form of gynecological cancer. This disease often goes undetected until advanced stages, resulting in high morbidity and mortality rates. Unfortunately, many patients experience relapse and succumb to the disease due to the emergence of drug resistance that [...] Read more.
Ovarian cancer is a highly lethal form of gynecological cancer. This disease often goes undetected until advanced stages, resulting in high morbidity and mortality rates. Unfortunately, many patients experience relapse and succumb to the disease due to the emergence of drug resistance that significantly limits the effectiveness of currently available oncological treatments. Here, we discuss the molecular mechanisms responsible for resistance to carboplatin, paclitaxel, polyadenosine diphosphate ribose polymerase inhibitors, and bevacizumab in ovarian cancer. We present a detailed analysis of the most extensively investigated resistance mechanisms, including drug inactivation, drug target alterations, enhanced drug efflux pumps, increased DNA damage repair capacity, and reduced drug absorption/accumulation. The in-depth understanding of the molecular mechanisms associated with drug resistance is crucial to unveil new biomarkers capable of predicting and monitoring the kinetics during disease progression and discovering new therapeutic targets. Full article
(This article belongs to the Special Issue Unlocking the Secrets behind Drug Resistance at the Cellular Level)
15 pages, 7147 KiB  
Article
Improving Scanning Performance of Patch Phased Array Antenna by Using a Modified SIW Cavity and Sequential Rotation Technique
by Hao Liu, Tianci Guan, Chunsen Fu, Shuqi Zhang, Xin Xu, Ziqiang Xu, Anyong Qing and Xianqi Lin
Electronics 2024, 13(9), 1776; https://doi.org/10.3390/electronics13091776 (registering DOI) - 04 May 2024
Abstract
A novel patch phased array antenna with improved scanning performance is presented in this paper. The active element pattern is changed as desired through a modified SIW cavity, resulting in an extension of the phased array’s 3 dB scanning range. Furthermore, sequential rotation [...] Read more.
A novel patch phased array antenna with improved scanning performance is presented in this paper. The active element pattern is changed as desired through a modified SIW cavity, resulting in an extension of the phased array’s 3 dB scanning range. Furthermore, sequential rotation is used to reduce the cross-polarization level of the array, which also improves the scanning gain at ±45°. Without altering the element size or profile, the array has the merits of low cost, low complexity, and a simple feed structure. The presented phased array antenna (PAA) exhibits a gain fluctuation of less than 2.2 dB when steering to 45°. Furthermore, the cross-polarization levels are below −68.1 dB when scanning to 45° in a E-/H-plane over the whole working band. To validate the proposed design, a prototype of a 24 × 16 active PAA is designed, fabricated, and measured. A good agreement between the simulated and measured results is achieved, Thus, this paper offers a viable solution to enhance the scanning performance of a PAA with fixed interelement spacing. Full article
(This article belongs to the Special Issue Recent Advances in Antenna Arrays and Millimeter-Wave Components)
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18 pages, 3869 KiB  
Article
Leveraging Temporal Information to Improve Machine Learning-Based Calibration Techniques for Low-Cost Air Quality Sensors
by Sharafat Ali, Fakhrul Alam, Johan Potgieter and Khalid Mahmood Arif
Sensors 2024, 24(9), 2930; https://doi.org/10.3390/s24092930 (registering DOI) - 04 May 2024
Abstract
Low-cost ambient sensors have been identified as a promising technology for monitoring air pollution at a high spatio-temporal resolution. However, the pollutant data captured by these cost-effective sensors are less accurate than their conventional counterparts and require careful calibration to improve their accuracy [...] Read more.
Low-cost ambient sensors have been identified as a promising technology for monitoring air pollution at a high spatio-temporal resolution. However, the pollutant data captured by these cost-effective sensors are less accurate than their conventional counterparts and require careful calibration to improve their accuracy and reliability. In this paper, we propose to leverage temporal information, such as the duration of time a sensor has been deployed and the time of day the reading was taken, in order to improve the calibration of low-cost sensors. This information is readily available and has so far not been utilized in the reported literature for the calibration of cost-effective ambient gas pollutant sensors. We make use of three data sets collected by research groups around the world, who gathered the data from field-deployed low-cost CO and NO2 sensors co-located with accurate reference sensors. Our investigation shows that using the temporal information as a co-variate can significantly improve the accuracy of common machine learning-based calibration techniques, such as Random Forest and Long Short-Term Memory. Full article
(This article belongs to the Section Sensor Networks)
17 pages, 1085 KiB  
Article
Design, Synthesis and Biological Activity of Novel Methoxy- and Hydroxy-Substituted N-Benzimidazole-Derived Carboxamides
by Anja Beč, Katarina Zlatić, Mihailo Banjanac, Vedrana Radovanović, Kristina Starčević, Marijeta Kralj and Marijana Hranjec
Molecules 2024, 29(9), 2138; https://doi.org/10.3390/molecules29092138 (registering DOI) - 04 May 2024
Abstract
This work presents the design, synthesis and biological activity of novel N-substituted benzimidazole carboxamides bearing either a variable number of methoxy and/or hydroxy groups. The targeted carboxamides were designed to investigate the influence of the number of methoxy and/or hydroxy groups, the [...] Read more.
This work presents the design, synthesis and biological activity of novel N-substituted benzimidazole carboxamides bearing either a variable number of methoxy and/or hydroxy groups. The targeted carboxamides were designed to investigate the influence of the number of methoxy and/or hydroxy groups, the type of substituent placed on the N atom of the benzimidazole core and the type of substituent placed on the benzimidazole core on biological activity. The most promising derivatives with pronounced antiproliferative activity proved to be N-methyl-substituted derivatives with hydroxyl and methoxy groups at the phenyl ring and cyano groups on the benzimidazole nuclei with selective activity against the MCF-7 cell line (IC50 = 3.1 μM). In addition, the cyano-substituted derivatives 10 and 11 showed strong antiproliferative activity against the tested cells (IC50 = 1.2–5.3 μM). Several tested compounds showed significantly improved antioxidative activity in all three methods compared to standard BHT. In addition, the antioxidative activity of 9, 10, 32 and 36 in the cells generally confirmed their antioxidant ability demonstrated in vitro. However, their antiproliferative activity was not related to their ability to inhibit oxidative stress nor to their ability to induce it. Compound 8 with two hydroxy and one methoxy group on the phenyl ring showed the strongest antibacterial activity against the Gram-positive strain E. faecalis (MIC = 8 μM). Full article
(This article belongs to the Special Issue Heterocycles in Medicinal Chemistry II)
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22 pages, 441 KiB  
Article
Social Determinants of Health and College Food Insecurity
by Catherine Mobley, Ye Luo, Mariela Fernandez and Leslie Hossfeld
Nutrients 2024, 16(9), 1391; https://doi.org/10.3390/nu16091391 (registering DOI) - 04 May 2024
Abstract
In recent years, many students have faced economic hardship and experienced food insecurity, even as universities strive to create more equitable pathways to college. There is a need for a more holistic perspective that addresses the complexity of food insecurity amongst college students. [...] Read more.
In recent years, many students have faced economic hardship and experienced food insecurity, even as universities strive to create more equitable pathways to college. There is a need for a more holistic perspective that addresses the complexity of food insecurity amongst college students. To this end, we examined the relationship between the social determinants of health, including college food insecurity (CoFI) and childhood food insecurity (ChFI), and their relationship with well-being measures. The study sample was a convenience sample that included 372 students at a public university who responded to an online survey in fall 2021. Students were asked to report their food security status in the previous 30 days. We used the following analytical strategies: chi-square tests to determine differences between food secure (FS) and food insecure (FI) students; binary logistic regression of CoFI on student demographics and ChFI; and ordinal or binary logistic regression for well-being measures. Black students, off-campus students, first-generation students, in-state students, and humanities/behavioral/social/health sciences majors were more likely to report CoFI. FI students were more likely to have experienced ChFI and to have lower scores on all well-being measures. ChFI was associated with four well-being measures and its effects were mediated by CoFI. College student health initiatives would benefit from accounting for SDOH, including ChFI experiences and its subsequent cumulative disadvantages experienced during college. Full article
(This article belongs to the Section Nutrition and Public Health)
17 pages, 11165 KiB  
Article
A Novel Multi-LiDAR-Based Point Cloud Stitching Method Based on a Constrained Particle Filter
by Gaofan Ji, Yunhan He, Chuanxiang Li, Li Fan, Haibo Wang and Yantong Zhu
Electronics 2024, 13(9), 1777; https://doi.org/10.3390/electronics13091777 (registering DOI) - 04 May 2024
Abstract
In coal-fired power plants, coal piles serve as the fundamental management units. Acquiring point clouds of coal piles facilitates the convenient measurement of daily coal consumption and combustion efficiency. When using servo motors to drive Light Detection and Ranging (LiDAR) scanning of large-scale [...] Read more.
In coal-fired power plants, coal piles serve as the fundamental management units. Acquiring point clouds of coal piles facilitates the convenient measurement of daily coal consumption and combustion efficiency. When using servo motors to drive Light Detection and Ranging (LiDAR) scanning of large-scale coal piles, the motors are subject to rotational errors due to gravitational effects. As a result, the acquired point clouds often contain significant noise. To address this issue, we proposes a Rapid Point Cloud Stitching–Constrained Particle Filter (RPCS-CPF) method. By introducing random noise to simulate servo motor rotational errors, both local and global point clouds are sequentially subjected to RPCS-CPF operations, resulting in smooth and continuous coal pile point clouds. Moreover, this paper presents a coal pile boundary detection method based on gradient region growing clustering. Experimental results demonstrate that our proposed RPCS-CPF method can generate smooth and continuous coal pile point clouds, even in the presence of servo motor rotational errors. Full article
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39 pages, 2537 KiB  
Article
Multi Criteria Frameworks Using New Meta-Heuristic Optimization Techniques for Solving Multi-Objective Optimal Power Flow Problems
by Murtadha Al-Kaabi, Virgil Dumbrava and Mircea Eremia
Energies 2024, 17(9), 2209; https://doi.org/10.3390/en17092209 (registering DOI) - 04 May 2024
Abstract
This article develops two metaheuristics optimization techniques, Grey Wolf Optimizer (GWO) and Harris Hawks Optimization (HHO), to handle multi-objective optimal power flow (MOOPF) issues. Multi Objective GWO (MOGWO) and Multi Objective HHO (MOHHO) are the names of the developed techniques. By combining these [...] Read more.
This article develops two metaheuristics optimization techniques, Grey Wolf Optimizer (GWO) and Harris Hawks Optimization (HHO), to handle multi-objective optimal power flow (MOOPF) issues. Multi Objective GWO (MOGWO) and Multi Objective HHO (MOHHO) are the names of the developed techniques. By combining these optimization techniques with Pareto techniques, the non-dominated solution set can be obtained. These developed approaches are characterized by simplicity and have few control parameters. Fuel cost, emissions, real power losses, and voltage deviation were the four objective functions considered. The theories used to determine the best compromise solution and organize the Pareto front options are the fuzzy membership equation and the crowding distance approach, respectively. To validate and evaluate the performance of the presented techniques, two standard IEEE bus systems—30-bus and 57-bus power systems—were proposed. Bi, Tri, and Quad objective functions with 21 case studies are the types of objective functions and the scenarios that were applied in this paper. As compared to the results of the most recent optimization techniques documented in the literature, the comparative analysis results for the proposed methodologies demonstrated the superiority and robustness of MOGWO and MOHHO. Full article
(This article belongs to the Section F1: Electrical Power System)
13 pages, 2301 KiB  
Article
The Psychological Impact on Romanian Women Infected with SARS-CoV-2 during Pregnancy
by Ruxandra-Gabriela Cigăran, Gheorghe Peltecu, Laura-Mihaela Mustață and Radu Botezatu
Healthcare 2024, 12(9), 945; https://doi.org/10.3390/healthcare12090945 (registering DOI) - 04 May 2024
Abstract
Background: It is well-known that the uncertainty about the COVID-19 pandemic has an indirect negative impact on pregnant women’s mental health, given the fact that pregnant women are more vulnerable emotionally and psychologically than non-pregnant women. The aim of this study was to [...] Read more.
Background: It is well-known that the uncertainty about the COVID-19 pandemic has an indirect negative impact on pregnant women’s mental health, given the fact that pregnant women are more vulnerable emotionally and psychologically than non-pregnant women. The aim of this study was to evaluate the maternal psychological impact on Romanian women who were infected with SARS-CoV-2 during pregnancy and their concerns and to determine which are the best measures to prevent negative outcomes. Methods: A 40-item questionnaire was created for data collection and was shared on social platforms (Facebook and Instagram) and also with obstetric communities between February 2021 and January 2023. Our cross-sectional survey recruited 317 Romanian pregnant women who suffered from SARS-CoV-2 infection. Among general questions about their life and pregnancy during the pandemic, the survey included questions about their SARS-CoV-2 infection during pregnancy, their concerns and how they perceived this period in order to evaluate their emotional status. Results: Of 317 women recruited, 91% of them had a mild to moderate form of COVID-19, and 2% had serious symptoms. Only 9% of women were hospitalized, 4% of women considered that the SARS-CoV-2 infection affected their physical condition to a great extent, and 8% considered to be affected in terms of mental state to a great extent. The main negative feelings of pregnant women during the COVID-19 disease were the fear regarding the possibility of affecting the pregnancy and the concern for their life (51.4%). These increase the risk of developing anxiety or depression. Pregnant women who contracted SARS-CoV-2 infection faced negative feelings, especially those with a severe form of the disease or who recovered with difficulty after the disease. Patients who required hospitalization reported an impairment of the mental state to a great extent and to a very great extent with a frequency of approximately two times and four times higher than non-hospitalized patients, respectively (p < 0.05 and p < 0.001, respectively). Also, giving birth during SARS-CoV-2 and the difficulty of accessing medical services represented a high level of stress. Also, 47% of patients who reported difficulty accessing medical services during the illness evaluated their mental state significantly less favorably. Conclusion: Preventive measures are essential to minimizing the negative psychological impact of COVID-19 disease during pregnancy among pregnant women. The medical treatment of COVID-19 disease during pregnancy should be prioritized, but emotional and mental health support must also be provided. Full article
17 pages, 4032 KiB  
Article
Pioglitazone Phases and Metabolic Effects in Nanoparticle-Treated Cells Analyzed via Rapid Visualization of FLIM Images
by Biagio Todaro, Luca Pesce, Francesco Cardarelli and Stefano Luin
Molecules 2024, 29(9), 2137; https://doi.org/10.3390/molecules29092137 (registering DOI) - 04 May 2024
Abstract
Fluorescence lifetime imaging microscopy (FLIM) has proven to be a useful method for analyzing various aspects of material science and biology, like the supramolecular organization of (slightly) fluorescent compounds or the metabolic activity in non-labeled cells; in particular, FLIM phasor analysis (phasor-FLIM) has [...] Read more.
Fluorescence lifetime imaging microscopy (FLIM) has proven to be a useful method for analyzing various aspects of material science and biology, like the supramolecular organization of (slightly) fluorescent compounds or the metabolic activity in non-labeled cells; in particular, FLIM phasor analysis (phasor-FLIM) has the potential for an intuitive representation of complex fluorescence decays and therefore of the analyzed properties. Here we present and make available tools to fully exploit this potential, in particular by coding via hue, saturation, and intensity the phasor positions and their weights both in the phasor plot and in the microscope image. We apply these tools to analyze FLIM data acquired via two-photon microscopy to visualize: (i) different phases of the drug pioglitazone (PGZ) in solutions and/or crystals, (ii) the position in the phasor plot of non-labelled poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs), and (iii) the effect of PGZ or PGZ-containing NPs on the metabolism of insulinoma (INS-1 E) model cells. PGZ is recognized for its efficacy in addressing insulin resistance and hyperglycemia in type 2 diabetes mellitus, and polymeric nanoparticles offer versatile platforms for drug delivery due to their biocompatibility and controlled release kinetics. This study lays the foundation for a better understanding via phasor-FLIM of the organization and effects of drugs, in particular, PGZ, within NPs, aiming at better control of encapsulation and pharmacokinetics, and potentially at novel anti-diabetics theragnostic nanotools. Full article
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15 pages, 593 KiB  
Article
An Improvement of Adam Based on a Cyclic Exponential Decay Learning Rate and Gradient Norm Constraints
by Yichuan Shao, Jiapeng Yang, Wen Zhou, Haijing Sun, Lei Xing, Qian Zhao and Le Zhang
Electronics 2024, 13(9), 1778; https://doi.org/10.3390/electronics13091778 (registering DOI) - 04 May 2024
Abstract
Aiming at a series of limitations of the Adam algorithm, such as hyperparameter sensitivity and unstable convergence, in this paper, an improved optimization algorithm, the Cycle-Norm-Adam (CN-Adam) algorithm, is proposed. The algorithm integrates the ideas of a cyclic exponential decay learning rate (CEDLR) [...] Read more.
Aiming at a series of limitations of the Adam algorithm, such as hyperparameter sensitivity and unstable convergence, in this paper, an improved optimization algorithm, the Cycle-Norm-Adam (CN-Adam) algorithm, is proposed. The algorithm integrates the ideas of a cyclic exponential decay learning rate (CEDLR) and gradient paradigm constraintsand accelerates the convergence speed of the Adam model and improves its generalization performance by dynamically adjusting the learning rate. In order to verify the effectiveness of the CN-Adam algorithm, we conducted extensive experimental studies. The CN-Adam algorithm achieved significant performance improvementsin both standard datasets. The experimental results show that the CN-Adam algorithm achieved 98.54% accuracy in the MNIST dataset and 72.10% in the CIFAR10 dataset. Due to the complexity and specificity of medical images, the algorithm was tested in a medical dataset and achieved an accuracy of 78.80%, which was better than the other algorithms. The experimental results show that the CN-Adam optimization algorithm provides an effective optimization strategy for improving model performance and promoting medical research. Full article
(This article belongs to the Special Issue Advances in Algorithm Optimization and Computational Intelligence)
16 pages, 5502 KiB  
Article
The Effect of Inhibiting the Wingless/Integrated (WNT) Signaling Pathway on the Early Embryonic Disc Cell Culture in Chickens
by Wenjie Ren, Dan Zheng, Guangzheng Liu, Gaoyuan Wu, Yixiu Peng, Jun Wu, Kai Jin, Qisheng Zuo, Yani Zhang, Guohui Li, Wei Han, Xiang-Shun Cui, Guohong Chen, Bichun Li and Ying-Jie Niu
Animals 2024, 14(9), 1382; https://doi.org/10.3390/ani14091382 (registering DOI) - 04 May 2024
Abstract
The utilization of chicken embryonic-derived pluripotent stem cell (PSC) lines is crucial in various fields, including growth and development, vaccine and protein production, and germplasm resource protection. However, the research foundation for chicken PSCs is relatively weak, and there are still challenges in [...] Read more.
The utilization of chicken embryonic-derived pluripotent stem cell (PSC) lines is crucial in various fields, including growth and development, vaccine and protein production, and germplasm resource protection. However, the research foundation for chicken PSCs is relatively weak, and there are still challenges in establishing a stable and efficient PSC culture system. Therefore, this study aims to investigate the effects of the FGF2/ERK and WNT/β-catenin signaling pathways, as well as different feeder layers, on the derivation and maintenance of chicken embryonic-derived PSCs. The results of this study demonstrate that the use of STO cells as feeder layers, along with the addition of FGF2, IWR-1, and XAV-939 (FIX), allows for the efficient derivation of chicken PSC-like cells. Under the FIX culture conditions, chicken PSCs express key pluripotency genes, such as POUV, SOX2, and NANOG, as well as specific proteins SSEA-1, C-KIT, and SOX2, indicating their pluripotent nature. Additionally, the embryoid body experiment confirms that these PSC-like cells can differentiate into cells of three germ layers in vitro, highlighting their potential for multilineage differentiation. Furthermore, this study reveals that chicken Eyal–Giladi and Kochav stage X blastodermal cells express genes related to the primed state of PSCs, and the FIX culture system established in this research maintains the expression of these genes in vitro. These findings contribute significantly to the understanding and optimization of chicken PSC culture conditions and provide a foundation for further exploration of the biomedical research and biotechnological applications of chicken PSCs. Full article
(This article belongs to the Section Poultry)
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15 pages, 4050 KiB  
Article
Transverse Spin Hall Effect and Twisted Polarization Ribbons at the Sharp Focus
by Victor V. Kotlyar, Alexey A. Kovalev, Alexey M. Telegin, Elena S. Kozlova, Sergey S. Stafeev, Alexander Kireev, Kai Guo and Zhongyi Guo
Appl. Sci. 2024, 14(9), 3926; https://doi.org/10.3390/app14093926 (registering DOI) - 04 May 2024
Abstract
In this work, using a Richards-Wolf formalism, we derive explicit analytical relationships to describe vectors of the major and minor axes of polarization ellipses centered in the focal plane when focusing a cylindrical vector beam of integer order n. In these beams, the [...] Read more.
In this work, using a Richards-Wolf formalism, we derive explicit analytical relationships to describe vectors of the major and minor axes of polarization ellipses centered in the focal plane when focusing a cylindrical vector beam of integer order n. In these beams, the major axis of a polarization ellipse is found to lie in the focal plane, with the minor axis being perpendicular to the focal plane. This means that the polarization ellipse is perpendicular to the focal plane, with its polarization vector rotating either clockwise or anticlockwise and forming “photonic wheels”. Considering that the wave vector is also perpendicular to the focal plane, we conclude that the polarization ellipse and the wave vector are in the same plane, so that at some point these can coincide, which is uncharacteristic of transverse electromagnetic oscillations. In a cylindrical vector beam, the spin angular momentum vector lies in the focal plane, so when making a circle centered on the optical axis, at some sections, the handedness of the spin vector and circular motion are the same, being opposite elsewhere. This effect may be called an azimuthal transverse spin Hall effect, unlike the familiar longitudinal spin Hall effect found at the sharp focus. The longitudinal spin Hall effect occurs when opposite-sign longitudinal projections of the spin angular momentum vector are spatially separated in the focal plane. In this work, we show that for the latter, there are always an even number of spatially separated regions and that, when making an axis-centered circle, the major-axis vector of polarization ellipse forms a two-sided twisted surface with an even number of twists. Full article
(This article belongs to the Section Optics and Lasers)
24 pages, 1171 KiB  
Review
Bone and Extracellular Signal-Related Kinase 5 (ERK5)
by Lei Wen, Zirui Liu, Libo Zhou, Zhongcheng Liu, Qingda Li, Bin Geng and Yayi Xia
Biomolecules 2024, 14(5), 556; https://doi.org/10.3390/biom14050556 (registering DOI) - 04 May 2024
Abstract
Bones are vital for anchoring muscles, tendons, and ligaments, serving as a fundamental element of the human skeletal structure. However, our understanding of bone development mechanisms and the maintenance of bone homeostasis is still limited. Extracellular signal-related kinase 5 (ERK5), a recently identified [...] Read more.
Bones are vital for anchoring muscles, tendons, and ligaments, serving as a fundamental element of the human skeletal structure. However, our understanding of bone development mechanisms and the maintenance of bone homeostasis is still limited. Extracellular signal-related kinase 5 (ERK5), a recently identified member of the mitogen-activated protein kinase (MAPK) family, plays a critical role in the pathogenesis and progression of various diseases, especially neoplasms. Recent studies have highlighted ERK5’s significant role in both bone development and bone-associated pathologies. This review offers a detailed examination of the latest research on ERK5 in different tissues and diseases, with a particular focus on its implications for bone health. It also examines therapeutic strategies and future research avenues targeting ERK5. Full article
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7 pages, 349 KiB  
Communication
Rikkosan’s Short-Term Analgesic Effect on Burning Mouth Syndrome: A Single-Arm Cohort Study
by Tatsuki Itagaki, Keisuke Nakamura, Tougo Tanabe, Takumi Shimura, Yu Nakai, Ken-ichiro Sakata, Jun Sato and Yoshimasa Kitagawa
Biomedicines 2024, 12(5), 1013; https://doi.org/10.3390/biomedicines12051013 (registering DOI) - 04 May 2024
Abstract
Burning mouth syndrome (BMS) is a chronic oral pain disorder. There is a theory that BMS is a form of nociplastic pain. A standard treatment for BMS has not yet been established. Kampo medicine is a traditional oriental medicine. The purpose of this [...] Read more.
Burning mouth syndrome (BMS) is a chronic oral pain disorder. There is a theory that BMS is a form of nociplastic pain. A standard treatment for BMS has not yet been established. Kampo medicine is a traditional oriental medicine. The purpose of this study is to evaluate the effectiveness of Rikkosan—a traditional Japanese herbal medicine (Kampo)—in the treatment of BMS. A single-center retrospective study was conducted on 20 patients who were diagnosed with BMS and treated with Rikkosan alone (total daily dose; 7.5 g) three times daily for approximately 4 weeks (29.5 ± 6.5 days). Rikkosan was dissolved in hot water and taken internally. They had an average age of 63 years, and 90% were being treated for other illnesses, but their medication status was the same during this study period, except for Rikkosan. No adverse events were observed in patients. Numerical rating scale (NRS) or visual analog scale (VAS)/10 scores decreased significantly between the time of the initiation of Rikkosan and one month after (−2.1 ± 1.2, p < 0.05). Rikkosan has a short-term effect of reducing NRS by two levels in BMS patients. Full article
14 pages, 2253 KiB  
Article
A Highly Homogeneous Airborne Fungal Community around a Copper Open Pit Mine Reveals the Poor Contribution Made by the Local Aerosolization of Particles
by Sebastián Fuentes-Alburquenque, Victoria Olivencia Suez, Omayra Aguilera, Blanca Águila, Luis Rojas Araya and Dinka Mandakovic
Microorganisms 2024, 12(5), 934; https://doi.org/10.3390/microorganisms12050934 (registering DOI) - 04 May 2024
Abstract
Fungi are ubiquitous and metabolically versatile. Their dispersion has important scientific, environmental, health, and economic implications. They can be dispersed through the air by the aerosolization of near surfaces or transported from distant sources. Here, we tested the contribution of local (scale of [...] Read more.
Fungi are ubiquitous and metabolically versatile. Their dispersion has important scientific, environmental, health, and economic implications. They can be dispersed through the air by the aerosolization of near surfaces or transported from distant sources. Here, we tested the contribution of local (scale of meters) versus regional (kilometers) sources by analyzing an airborne fungal community by ITS sequencing around a copper mine in the North of Chile. The mine was the regional source, whereas the soil and vegetal detritus were the local sources at each point. The airborne community was highly homogeneous at ca. 2000 km2, impeding the detection of regional or local contributions. Ascomycota was the dominant phylum in the three communities. Soil and vegetal detritus communities had lower alpha diversity, but some taxa had abundance patterns related to the distance from the mine and altitude. On the contrary, the air was compositionally even and unrelated to environmental or spatial factors, except for altitude. The presence of plant pathogens in the air suggests that other distant sources contribute to this region’s airborne fungal community and reinforces the complexity of tracking the sources of air microbial communities in a real world where several natural and human activities coexist. Full article
(This article belongs to the Special Issue Airborne Microbial Communities)
29 pages, 3087 KiB  
Article
Hunting Search Algorithm-Based Adaptive Fuzzy Tracking Controller for an Aero-Pendulum
by Ricardo Rojas-Galván, José R. García-Martínez, Edson E. Cruz-Miguel, Omar A. Barra-Vázquez, Luis F. Olmedo-García and Juvenal Rodríguez-Reséndiz
Technologies 2024, 12(5), 63; https://doi.org/10.3390/technologies12050063 (registering DOI) - 04 May 2024
Abstract
The aero-pendulum is a non-linear system used broadly to develop and test new controller strategies. This paper presents a new methodology for an adaptive PID fuzzy-based tracking controller using a Hunting Search (HuS) algorithm. The HuS algorithm computes the parameters of the membership [...] Read more.
The aero-pendulum is a non-linear system used broadly to develop and test new controller strategies. This paper presents a new methodology for an adaptive PID fuzzy-based tracking controller using a Hunting Search (HuS) algorithm. The HuS algorithm computes the parameters of the membership functions of the fuzzification stage. As a novelty, the algorithm guarantees the overlap of the membership functions to ensure that all the functions are interconnected, generating new hunters to search for better solutions in the overlapping area. For the defuzzification stage, the HuS algorithm sets the singletons in optimal positions to evaluate the controller response using the centroid method. To probe the robustness of the methodology, the PID fuzzy controller algorithm is implemented in an embedded system to track the angular position of an aero-pendulum test bench. The results show that the adaptive PID fuzzy controller proposed presents root mean square error values of 0.42, 0.40, and 0.49 for 80, 90, and 100 degrees, respectively. Full article
(This article belongs to the Special Issue Smart Systems (SmaSys2023))
15 pages, 2371 KiB  
Article
Radiographic Study of Transcrestal Sinus Floor Elevation Using Osseodensification Technique with Graft Material: A Pilot Study
by Khrystyna Sulyhan-Sulyhan, Javier Barberá-Millán, Carolina Larrazábal-Morón, Julián Espinosa-Giménez and María Dolores Gómez-Adrián
Biomimetics 2024, 9(5), 276; https://doi.org/10.3390/biomimetics9050276 (registering DOI) - 04 May 2024
Abstract
This pilot study aimed to evaluate the level of implant success after transcrestal sinus floor elevation (tSFE) using the osseodensification technique (OD) combined with beta-tricalcium phosphate (β-TCP) by analyzing clinical and radiographic results. Moreover, the increase in bone height was analyzed immediately after [...] Read more.
This pilot study aimed to evaluate the level of implant success after transcrestal sinus floor elevation (tSFE) using the osseodensification technique (OD) combined with beta-tricalcium phosphate (β-TCP) by analyzing clinical and radiographic results. Moreover, the increase in bone height was analyzed immediately after surgery, 3 months after, and before loading by taking standardized radiographic measurements. Thirteen patients, four males and nine females, with a mean age of 54.69 ± 5.86 years, requiring the placement of one implant in the upper posterior maxilla, with a residual bone height of <8 mm and a minimum bone width of 5 mm, participated in the study. The bone gain data was obtained using cone-beam computed tomography (CBCT) immediately after surgery and twelve months after the placement. The correlation between initial and final bone height with implant stability was also assessed. The results were analyzed using SPSS 23 software (p < 0.05). The results of the study indicated a 100% implant success rate after a follow-up period of twelve months. Preoperative main bone height was 5.70 ± 0.95 mm. The osseodensification technique allowed a significant increase of 6.65 ± 1.06 mm immediately after surgery. After a twelve-month follow-up, a graft material contraction of 0.90 ± 0.49 mm was observed. No correlation was observed between the bone height at the different times of the study and the primary stability of the implant. Considering the limitations of the size sample of this study, the osseodensification technique used for transcrestal sinus lift with the additional bone graft material (β-TCP) may provide a predictable elevation of the maxillary sinus floor, allowing simultaneous implant insertion with adequate stability irrespective of bone height limitations. Full article
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12 pages, 2743 KiB  
Article
Plastic and Reconstructive Surgery in the Wake of the Eid al-Adha: A Single-Center, Five-Year Investigation
by Mehmet Tapan, Burak Yaşar, Hasan Murat Ergani and Süleyman Can Ceylan
J. Clin. Med. 2024, 13(9), 2704; https://doi.org/10.3390/jcm13092704 (registering DOI) - 04 May 2024
Abstract
(1) Background: The Festival of Sacrifice, commonly known as Eid al-Adha, has a profound religious and cultural impact on nations with a Muslim majority. This festival is celebrated every year in Muslim countries; however, it is a time in which patients present to [...] Read more.
(1) Background: The Festival of Sacrifice, commonly known as Eid al-Adha, has a profound religious and cultural impact on nations with a Muslim majority. This festival is celebrated every year in Muslim countries; however, it is a time in which patients present to the emergency department with serious injuries. In our study, we examined current injuries occurring during Eid al-Adha in one of the largest hospitals in Türkiye, providing the largest patient population to date. This included mapping tendon and maxillofacial injuries, a first in the literature. To the best of our knowledge, this is the largest case series of injuries sustained during Eid al-Adha. The significance of this study lies in its potential to significantly benefit patients and healthcare systems by providing reference data. (2) Methods: Patients admitted to Ankara City Hospital during Eid al-Adha between 2019 and 2023 were examined. The demographic characteristics, injury patterns, and injury sites of patients admitted on the four days of Eid al-Adha were collected and analyzed. Maxillofacial traumas during the festival were analyzed. Tendon injuries on the left hand, which is the most commonly injured body part in the literature, were mapped into a figure. To compare the change in the number of patients, a comparison was made with the number of patients in our hospital for four consecutive days 2 weeks before Eid. Statistical analysis was performed using IBM SPSS Statistics for Windows. (3) Results: A total of 610 patients, including 101 female and 509 male patients, were included in this study. A statistically significant increase (p < 0.001 for all years) in hospital admission due to injury was observed. Individuals between the ages of 30 and 40 years were the most frequently admitted patients (n = 182, 29.8%). Knife injuries were significantly more common in all patients (p < 0.001). When the total number of patients was evaluated in terms of injured areas where patients present to the emergency department, left-hand injuries were found to be significantly more common than injuries in other areas (p < 0.001 for all). The extensor pollicus longus tendon was the most commonly injured tendon among all extensor and flexor tendon injuries (n = 104). The most commonly injured tendon was the flexor tendon in zone 2 of the first finger (n = 45). This study showed that injuries to the extensor tendon in zone 1 of the fifth finger, the flexor tendon in zone 4 of the first finger, and the flexor tendon in zone 1 of the fifth finger were never seen. Twenty-five patients with maxillofacial injuries were admitted to the hospital. Orbital floor fractures were the most common type of maxillofacial injury. The anesthesia technique we preferred for all patients was local anesthesia (n = 267). Wide-awake local anesthesia no tourniquet (WALANT) was the second most preferred anesthetic technique. The number of patients who were selected in a random 4-day period for each year were compared with the number of patients who came during Eid al-Adha. The Mann–Whitney U tests revealed a significant increase in injuries on the first day of Eid al-Adha compared to non-festival days (p < 0.001). However, no significant differences were observed on the subsequent days or in the overall injury counts during the festival period (p = 0.841 for day 2, p = 0.151 for day 3, p = 0.310 for day 4). (4) Conclusions: According to this study, which is the largest known case series in the literature, the number of patients admitted to the hospital increased annually. In our study, we observed a significant increase in injuries only on the first day of Eid al-Adha compared to a randomly selected 4-day period of the same year. Left-hand extensor tendon injuries from a knife were the most common injuries in middle-aged men. The extensor pollicis longus tendon was the most commonly injured extensor tendon, with zones 3 and 4 being the most commonly affected. The flexor pollicis longus tendon was the most commonly injured flexor tendon in zone 2. During this period, patients may not only need hand surgery but also maxillofacial plastic surgery. We recommend, in addition to the indications I,n the literature that during Eid al-Adha, the WALANT technique should be widely adopted in patients where local anesthesia will be insufficient. We also recommend utilizing a diagram to manage the patient load during Eid al-Adha and prevent overburdening the healthcare system. Full article
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16 pages, 601 KiB  
Article
The Effects of Tillage and the Combined Application of Organic and Inorganic Fertilizers on the Antioxidant Enzyme Activity and Yield of Maize Leaves
by Guangming Xie, Min Liang, Pei Chen, Chang Zhang, Mingyuan Fan, Chuangyun Wang and Li Zhao
Agronomy 2024, 14(5), 968; https://doi.org/10.3390/agronomy14050968 (registering DOI) - 04 May 2024
Abstract
The aim of this study was to explore the characteristics of the combined application of organic fertilizer and inorganic fertilizer using different tillage methods to delay the senescence of maize leaves. The yield and activities of GDH, CAT, APX, GR, and GSH enzymes [...] Read more.
The aim of this study was to explore the characteristics of the combined application of organic fertilizer and inorganic fertilizer using different tillage methods to delay the senescence of maize leaves. The yield and activities of GDH, CAT, APX, GR, and GSH enzymes in maize leaves were measured at different growth stages by using two tillage methods, three organic and inorganic combined applications (P1, P2, and P3), and four control treatments. (1) During the growth period, the R + S and R treatments were P1 treatments, with the highest enzyme activities noted for GDH, CAT, APX, GR, and GSH, which were 36.79–103.22% higher than those of CK. (2) The average yield of all R + S treatments was higher than that of R treatments, and the average yield of P1 treatment was the highest under R + S, which was 13,663.79 kg hm2, which was 6.39%, 7.90%, and 14.67% higher than that of P2, P3, and CK, respectively, which was lower than that of R. The yield of P1 treatment was 2.53% higher. (3) There was a significant positive correlation between APX activity, CAT activity, GR activity, GDH activity, GSH activity, grain number per ear, ear length, and 100-grain weight of maize leaves at the grain filling stage, and a significant negative correlation between bald tip length and yield. The treatment details had the strongest enzyme activity and the highest yield when using the rotary tillage + subsoiling (R + S) P1 method, which was the most suitable tillage method and the best fertilizer ratio combination, which could be demonstrated and popularized in a large area in the dry farming area of spring maize in Shanxi Province. Full article
17 pages, 3007 KiB  
Article
Indoor Environmental Quality for Comfort Learning Environments: Case Study of Palestinian School Buildings
by Aya Baba, Isam Shahrour and Mutasim Baba
Buildings 2024, 14(5), 1296; https://doi.org/10.3390/buildings14051296 (registering DOI) - 04 May 2024
Abstract
This research evaluates the quality of the indoor environment and comfort of Palestinian public schools. The importance of this study is related to the pivotal role of indoor environmental quality (IEQ) on students’ health, well-being, and academic performance, especially in a region facing [...] Read more.
This research evaluates the quality of the indoor environment and comfort of Palestinian public schools. The importance of this study is related to the pivotal role of indoor environmental quality (IEQ) on students’ health, well-being, and academic performance, especially in a region facing significant challenges such as limited financial resources and diverse climate conditions. Unlike traditional technical evaluations, this research uses a post-occupancy evaluation (POE) methodology. This research is based on a questionnaire about classes’ indoor environment and comfort parameters, including thermal comfort, lighting, acoustics, indoor air quality, and ergonomic environment. The research focuses on students’ overall well-being, considering factors often overlooked in traditional assessments. Key findings reveal significant challenges in thermal conditions due to inadequate heating, cooling, and ventilation systems and a lack of passive thermal design. High carbon dioxide levels in classrooms due to inadequate ventilation highlight a second critical challenge. Schools also suffered from noise pollution due to the absence of noise-absorbing materials. Students expressed their satisfaction with the lighting and indoor ergonomic comfort. This research resulted in recommendations to address classrooms’ IEQ challenges, focusing on strategies to improve thermal comfort, acoustics, and indoor air quality. Full article
(This article belongs to the Section Building Energy, Physics, Environment, and Systems)
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