The 2023 MDPI Annual Report has
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14 pages, 575 KiB  
Article
The Healthy Fatty Index Allows for Deeper Insights into the Lipid Composition of Foods of Animal Origin when Compared with the Atherogenic and Thrombogenicity Indexes
by Alessandro Dal Bosco, Massimiliano Cavallo, Laura Menchetti, Elisa Angelucci, Alice Cartoni Mancinelli, Gaetano Vaudo, Stefania Marconi, Emanuela Camilli, Francesco Galli, Cesare Castellini and Simona Mattioli
Foods 2024, 13(10), 1568; https://doi.org/10.3390/foods13101568 - 17 May 2024
Abstract
The aim of this research was to validate the effectiveness of the Healthy Fatty Index (HFI) regarding some foods of animal origin (meat, processed, fish, milk products, and eggs) typical of the Western diet and to compare these results with two consolidated indices [...] Read more.
The aim of this research was to validate the effectiveness of the Healthy Fatty Index (HFI) regarding some foods of animal origin (meat, processed, fish, milk products, and eggs) typical of the Western diet and to compare these results with two consolidated indices (atherogenic—AI, and thrombogenic—TI) in the characterization of the nutritional features of their lipids. The fatty acids profile (% of total fatty acids and mg/100 g) of 60 foods, grouped in six subclasses, was used. The AI, TI, and HFI indexes were calculated, and the intraclass correlation coefficients and the degree of agreement were evaluated using different statistical approaches. The results demonstrated that HFI, with respect to AI and TI, seems better able to consider the complexity of the fatty acid profile and the different fat contents. HFI and AI are the two most diverse indices, and they can provide different food classifications. AI and IT exhibit only a fair agreement in regards to food classification, confirming that such indexes are always to be considered indissolubly and never separately, in contrast to the HFI, which can stand alone. Full article
(This article belongs to the Section Food Nutrition)
11 pages, 7348 KiB  
Article
A Proximity-Based Approach for the Identification of Fallen Species of Street Trees during Strong Wind Events in Lisbon
by Flávio Henrique Mendes, Felipe Coelho de Souza Petean, Ezequiel Luís Tavares Correia and António Manuel Saraiva Lopes
Land 2024, 13(5), 708; https://doi.org/10.3390/land13050708 (registering DOI) - 17 May 2024
Abstract
The benefits of urban trees are very well known, but they can fall and cause damage, putting people’s lives at risk. There are few studies on the vulnerability of species to falling. In Lisbon (Portugal), fallen trees have been recorded since 1990 without, [...] Read more.
The benefits of urban trees are very well known, but they can fall and cause damage, putting people’s lives at risk. There are few studies on the vulnerability of species to falling. In Lisbon (Portugal), fallen trees have been recorded since 1990 without, however, the identification of the species, knowledge of which is fundamental for improving their management. This study aimed to identify the tree species most vulnerable to falling in Lisbon through a proximity-based approach of known species, since the city has 47,713 inventoried trees, of which only 26,595 (55.7%) were identified. Four criteria were designed to presume the species: (i) the tree must be within 15 m from the street median axis; (ii) at least three individuals within 30 m from the occurrence must belong to the same species; (iii) the surrounding species must be representative in the street (>50%); and (iv) visual identification of avenue medians. Through this approach, considering 3767 fallen trees, it was possible to identify 736 cases, representing 19.5% of all occurrences throughout the studied time and representing 43 different species. Species like Morus nigra L., Tipuana tipu (Benth.) Kuntze, Liriodendron tulipifera L., Prunus cerasifera Ehrh., and Koelreuteria paniculata Laxm. were most vulnerable. Additionally, in 57.7% of cases (425 fallen trees), the wind speed 12-h before the occurrence was greater than 7 m s−1. This research will provide important data for urban planners seeking to maximize the ecosystem services of urban trees. Full article
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15 pages, 1060 KiB  
Article
Individually Cultured Bovine Zygotes Successfully Develop to the Blastocyst Stage in an Extremely Confined Environment
by Angela Travaglione, Andrea Candela, Vincenza De Gregorio, Vincenzo Genovese, Mario Cimmino, Vincenza Barbato, Riccardo Talevi and Roberto Gualtieri
Cells 2024, 13(10), 868; https://doi.org/10.3390/cells13100868 (registering DOI) - 17 May 2024
Abstract
The possibility of detecting the developmental competence of individually cultured embryos through analysis of spent media is a major current trend in an ART setting. However, individual embryo culture is detrimental compared with high-density group culture due to the reduced concentration of putative [...] Read more.
The possibility of detecting the developmental competence of individually cultured embryos through analysis of spent media is a major current trend in an ART setting. However, individual embryo culture is detrimental compared with high-density group culture due to the reduced concentration of putative embryotropins. The main aim of this study was to identify an individual culture system that is not detrimental over high-density group culture in the bovine model. Blastocyst rates and competence were investigated in a conventional (GC) group, semi-confined group (MG), and individual culture (MS) in a commercial microwell device. Main findings showed that: (1) individual embryos can be continuously cultured for 7 days in ~70 nL microwells (MS) without detrimental effects compared with the GC and MG; (2) MS and MG blastocysts had a reduced number of TUNEL-positive cells compared to GC blastocysts; (3) though blastocyst mean cell numbers, mitochondrial activity, and lipid content were not different among the three culture conditions, MS blastocysts had a higher frequency of small-sized lipid droplets and a reduced mean droplet diameter compared with GC and MG blastocysts. Overall, findings open the way to optimize the development and competence of single embryos in an ART setting. Full article
(This article belongs to the Section Reproductive Cells and Development)
14 pages, 1237 KiB  
Article
Soluble Fluorinated Cardo Copolyimide as an Effective Additive to Photopolymerizable Compositions Based on Di(meth)acrylates: Application for Highly Thermostable Primary Protective Coating of Silica Optical Fiber
by Dmitriy A. Sapozhnikov, Olga A. Melnik, Alexander V. Chuchalov, Roman S. Kovylin, Sergey A. Chesnokov, Dmitriy A. Khanin, Galina G. Nikiforova, Alexey F. Kosolapov, Sergey L. Semjonov and Yakov S. Vygodskii
Int. J. Mol. Sci. 2024, 25(10), 5494; https://doi.org/10.3390/ijms25105494 (registering DOI) - 17 May 2024
Abstract
The development of photocurable compositions is in high demand for the manufacture of functional materials for electronics, optics, medicine, energy, etc. The properties of the final photo-cured material are primarily determined by the initial mixture, which needs to be tuned for each application. [...] Read more.
The development of photocurable compositions is in high demand for the manufacture of functional materials for electronics, optics, medicine, energy, etc. The properties of the final photo-cured material are primarily determined by the initial mixture, which needs to be tuned for each application. In this study we propose to use simple systems based on di(meth)acrylate, polyimide and photoinitiator for the preparation of new photo-curable compositions. It was established that a fluorinated cardo copolyimide (FCPI) based on 2,2-bis-(3,4-dicarboxydiphenyl)hexafluoropropane dianhydride, 9,9-bis-(4-aminophenyl)fluorene and 2,2-bis-(4-aminophenyl)hexafluoropropane (1.00:0.75:0.25 mol) has excellent solubility in di(met)acrylates. This made it possible to prepare solutions of FCPI in such monomers, to study the effect of FCPI on the kinetics of their photopolymerization in situ and the properties of the resulting polymers. According to the obtained data, the solutions of FCPI (23 wt.%) in 1,4-butanediol diacrylate (BDDA) and FCPI (15 wt.%) in tetraethylene glycol diacrylate were tested for the formation of the primary protective coatings of the silica optical fibers. It was found that the new coating of poly(BDDA–FCPI23%) can withstand prolonged annealing at 200 °C (72 h), which is comparable or superior to the known most thermally stable photo-curable coatings. The proposed approach can be applied to obtain other functional materials. Full article
(This article belongs to the Special Issue Synthesis, Properties and Applications of Polymers)
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20 pages, 2023 KiB  
Article
Critical Threshold-Based Heat Damage Evolution Monitoring to Tea Plants with Remotely Sensed LST over Mainland China
by Peijuan Wang, Xin Li, Junxian Tang, Dingrong Wu, Lifeng Pang and Yuanda Zhang
Remote Sens. 2024, 16(10), 1784; https://doi.org/10.3390/rs16101784 (registering DOI) - 17 May 2024
Abstract
Tea plants (Camellia sinensis (L.) Kuntze) are a cash crop that thrive under warm and moist conditions. However, tea plants are becoming increasingly vulnerable to heat damage (HD) during summer growing seasons due to global climate warming. Because China ranks first in [...] Read more.
Tea plants (Camellia sinensis (L.) Kuntze) are a cash crop that thrive under warm and moist conditions. However, tea plants are becoming increasingly vulnerable to heat damage (HD) during summer growing seasons due to global climate warming. Because China ranks first in the world in both harvested tea area and total tea production, monitoring and tracking HD to tea plants in a timely manner has become a significant and urgent task for scientists and tea producers in China. In this study, the spatiotemporal characteristics of HD evolution were analyzed, and a tracking method using HD LST-weighted geographical centroids was constructed based on HD pixels identified by the critical LST threshold and daytime MYD11A1 products over the major tea planting regions of mainland China from two typical HD years (2013 and 2022). Results showed that the average number of HD days in 2022 was five more than in 2013. Daily HD extent increased at a rate of 0.66% per day in 2022, which was faster than that in 2013 with a rate of 0.21% per day. In two typical HD years, the tea regions with the greatest HD extent were concentrated south of the Yangtze River (SYR), with average HD pixel ratios of greater than 50%, then north of the Yangtze River (NYR) and southwest China (SWC), with average HD pixel ratios of around 40%. The regions with the least HD extent were in South China (SC), where the HD ratios were less than 40%. The HD LST-weighted geographical centroid trajectories showed that HD to tea plants in 2013 initially moved from southwest to northeast, and then moved west. In 2022, HD moved from northeast to west and south. Daily HD centroids were mainly concentrated at the conjunction of SYR, SWC, and SC in 2013, and in northern SWC in 2022, where they were near to the centroid of the tea planting gardens. The findings in this study confirmed that monitoring HD evolution of tea plants over a large spatial extent based on reconstructed remotely sensed LST values and critical threshold was an effective method benefiting from available MODIS LST products. Moreover, this method can identify and track the spatial distribution characteristics of HD to tea plants in a timely manner, and it will therefore be helpful for taking effective preventative measures to mitigate economic losses resulting from HD. Full article
(This article belongs to the Special Issue Remote Sensing in Hazards Monitoring and Risk Assessment)
26 pages, 13608 KiB  
Article
Optimizing Residential Construction Site Selection in Mountainous Regions Using Geospatial Data and eXplainable AI
by Dhafer Alqahtani, Javed Mallick, Abdulmohsen M. Alqahtani and Swapan Talukdar
Sustainability 2024, 16(10), 4235; https://doi.org/10.3390/su16104235 (registering DOI) - 17 May 2024
Abstract
The rapid urbanization of Abha and its surrounding cities in Saudi Arabia’s mountainous regions poses challenges for sustainable and secure development. This study aimed to identify suitable sites for eco-friendly and safe building complexes amidst complex geophysical, geoecological, and socio-economic factors, integrating natural [...] Read more.
The rapid urbanization of Abha and its surrounding cities in Saudi Arabia’s mountainous regions poses challenges for sustainable and secure development. This study aimed to identify suitable sites for eco-friendly and safe building complexes amidst complex geophysical, geoecological, and socio-economic factors, integrating natural hazards assessment and risk management. Employing the Fuzzy Analytic Hierarchy Process (Fuzzy-AHP), the study constructed a suitability model incorporating sixteen parameters. Additionally, a Deep Neural Network (DNN) based on eXplainable Artificial Intelligence (XAI) conducted sensitivity analyses to assess the parameters’ influence on optimal location decision making. The results reveal slope as the most crucial parameter (22.90%), followed by altitude and land use/land cover (13.24%), emphasizing topography and environmental considerations. Drainage density (11.36%) and rainfall patterns (9.15%) are also significant for flood defense and water management. Only 12.21% of the study area is deemed “highly suitable”, with “no-build zones” designated for safety and environmental protection. DNN-based XAI demonstrates the positive impact of variables like the NDVI and municipal solid waste generation on site selection, informing waste management and ecological preservation strategies. This integrated methodology provides actionable insights for sustainable and safe residential development in Abha, aiding informed decision making and balancing urban expansion with environmental conservation and hazard risk reduction. Full article
(This article belongs to the Section Sustainability in Geographic Science)
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12 pages, 260 KiB  
Article
Canine Oral Melanoma: Questioning the Existing Information through a Series of Clinical Cases
by Carmen G. Pérez-Santana, Ana A. Jiménez-Alonso, Francisco Rodríguez-Esparragón, Sara Cazorla-Rivero and Enrique Rodríguez Grau-Bassas
Vet. Sci. 2024, 11(5), 226; https://doi.org/10.3390/vetsci11050226 (registering DOI) - 17 May 2024
Abstract
Twelve dogs with oral malignant melanomas (MM) were evaluated in this study, with demographic details indicating a balanced distribution of gender, age, and weight among various breeds. Tumor locations varied, with diverse surgical procedures being performed, including mandibulectomies and maxillectomies. Lymphadenectomies were conducted, [...] Read more.
Twelve dogs with oral malignant melanomas (MM) were evaluated in this study, with demographic details indicating a balanced distribution of gender, age, and weight among various breeds. Tumor locations varied, with diverse surgical procedures being performed, including mandibulectomies and maxillectomies. Lymphadenectomies were conducted, revealing a 16.66% metastatic rate in regional lymph nodes. At the time of surgery, clinical staging identified stages I, II, and III, with most cases having non-infiltrated margins and a high mitotic index. Follow-up revealed local recurrences and metastases, prompting additional surgeries and affecting survival rates. This study reports varying outcomes, with some dogs completing one year without recurrence, while others experienced progressive disease, leading to six oral melanoma-related deaths. The characteristics of melanotic melanoma and amelanotic melanoma are observed in order to study differences between them, the degree of aggressiveness, the mortality rate and the possibility of future therapeutic targets. Although high pigmentation has been correlated with a better outcome, we could not find any significant correlation between survival and achromia. Oral benign melanomas might exist, and this could justify variabilities between stage and survival; however, carefulness is required due to their unpredictable behavior. The findings underscore the complexity of oral melanoma cases and highlight the need for further research on effective management strategies. Full article
18 pages, 1940 KiB  
Article
Alcohol Exposure and Disease Associations: A Mendelian Randomization and Meta-Analysis on Weekly Consumption and Problematic Drinking
by Mengyao Li, Xuying Zhang, Kailei Chen, Yang Miao, Yaxin Xu, Yishuo Sun, Mengxian Jiang, Mengcao Liu, Yan Gao, Xiaoxia Xue and Xuelian Li
Nutrients 2024, 16(10), 1517; https://doi.org/10.3390/nu16101517 (registering DOI) - 17 May 2024
Abstract
Alcohol consumption significantly impacts disease burden and has been linked to various diseases in observational studies. However, comprehensive meta-analyses using Mendelian randomization (MR) to examine drinking patterns are limited. We aimed to evaluate the health risks of alcohol use by integrating findings from [...] Read more.
Alcohol consumption significantly impacts disease burden and has been linked to various diseases in observational studies. However, comprehensive meta-analyses using Mendelian randomization (MR) to examine drinking patterns are limited. We aimed to evaluate the health risks of alcohol use by integrating findings from MR studies. A thorough search was conducted for MR studies focused on alcohol exposure. We utilized two sets of instrumental variables—alcohol consumption and problematic alcohol use—and summary statistics from the FinnGen consortium R9 release to perform de novo MR analyses. Our meta-analysis encompassed 64 published and 151 de novo MR analyses across 76 distinct primary outcomes. Results show that a genetic predisposition to alcohol consumption, independent of smoking, significantly correlates with a decreased risk of Parkinson’s disease, prostate hyperplasia, and rheumatoid arthritis. It was also associated with an increased risk of chronic pancreatitis, colorectal cancer, and head and neck cancers. Additionally, a genetic predisposition to problematic alcohol use is strongly associated with increased risks of alcoholic liver disease, cirrhosis, both acute and chronic pancreatitis, and pneumonia. Evidence from our MR study supports the notion that alcohol consumption and problematic alcohol use are causally associated with a range of diseases, predominantly by increasing the risk. Full article
(This article belongs to the Section Nutrition and Public Health)
17 pages, 1043 KiB  
Article
Use of Botanical Ingredients: Nice Opportunities to Avoid Premature Oxidation of NABLABs by Increasing Their ORAC Values Strongly Impacted by Dealcoholization or Pasteurization
by Margaux Simon, Hubert Kageruka and Sonia Collin
Molecules 2024, 29(10), 2370; https://doi.org/10.3390/molecules29102370 (registering DOI) - 17 May 2024
Abstract
Even when fresh, non-alcoholic, and low-alcoholic beers (NABLABs) exhibit significant staling defects due to premature oxidation. In this study, the antioxidant power of eleven fresh commercial NABLABs was assessed by means of three different assays: the oxygen radical absorbance capacity (ORAC), the linoleic [...] Read more.
Even when fresh, non-alcoholic, and low-alcoholic beers (NABLABs) exhibit significant staling defects due to premature oxidation. In this study, the antioxidant power of eleven fresh commercial NABLABs was assessed by means of three different assays: the oxygen radical absorbance capacity (ORAC), the linoleic acid-induced oxidation (TINH), and the indicator time test (ITT). Only the first two assays, both involving radicalar degradations initiated by AAPH, were found to correlate with each other. NABLABs displayed lower ORAC values than conventional beers (on average, 6127 μmol eq. Trolox/L), except for three samples made with special-colored malts or dry-hopped. Dealcoholization was the step with the greatest impact on the ORAC value (up to a 95% loss) and on flavan-3-ols, sotolon, and polyfunctional thiols, while pasteurization strongly affected color, TBA, and Strecker aldehydes. ORAC assays applied to hop, alternative cereals, and various botanical ingredients indicated that mashing with red sorghum, dry hopping/spicing, and wood maturation could bring the antioxidant power of a NABLAB close to those of conventional beers. With an ORAC value not reached by any other tested botanical ingredient (5234 µmol eq. Trolox/g), African Vernonia amygdalina leaves (traditionally used for Rwandan Ikigage beers) emerged here as the best candidate. Full article
(This article belongs to the Section Flavours and Fragrances)
9 pages, 295 KiB  
Communication
Sleep Quality in Greek Adolescent Swimmers
by Vasileios T. Stavrou, George D. Vavougios, Glykeria Tsirimona, Zoe Daniil and Konstantinos I. Gourgoulianis
J. Funct. Morphol. Kinesiol. 2024, 9(2), 87; https://doi.org/10.3390/jfmk9020087 (registering DOI) - 17 May 2024
Abstract
The aim of our study was to investigate the relationship between sleep quality and functional indices, swimming distance and gender in adolescent competitive swimmers. Forty-eight adolescent swimmers (boys, n = 22, 15.7 ± 1.0 years and girls, n = 26, 15.1 ± 0.8 [...] Read more.
The aim of our study was to investigate the relationship between sleep quality and functional indices, swimming distance and gender in adolescent competitive swimmers. Forty-eight adolescent swimmers (boys, n = 22, 15.7 ± 1.0 years and girls, n = 26, 15.1 ± 0.8 years) were included in our study. They were assessed for handgrip strength, respiratory muscle strength and pulmonary function, answered a Pittsburg Sleep Quality Index questionnaire (PSQI), and recorded their anthropometric and morphological characteristics and training load for the last four weeks. The results showed differences between swimming distance and chest circumference difference, between maximal inhalation and exhalation (Δchest) (p = 0.033), PSQI score (p < 0.001), and sleep quality domains for “cannot breathe comfortably” (p = 0.037) and “have pain” (p = 0.003). Binary logistic regression (chi-square = 37.457, p = 0.001) showed that the variables Δchest (p = 0.038, 95% CI: 1.05–6.07) and PSQI score (p = 0.048, 95% CI: 0.1–1.07) remained independent predictors of the swim distance groups. Girls had a lower percentage of predicted values for the maximal inspiratory pressure (p < 0.001), maximal expiratory pressure (p = 0.027), forced expiratory volume within the first second (p = 0.026), forced vital capacity (p = 0.008) and sleep quality domains for “cough or snore loudly” (p = 0.032) compared to boys. A regression analysis showed that the sleep quality score was explained by the six independent variables: respiratory muscle strength (t = 2.177, β = 0.164, p = 0.035), Δchest (t = −2.353, β = −0.17, p = 0.023), distance (t = −5.962, β = −0.475, p < 0.001), total body water (t = −7.466, β = −0.687, p < 0.001), lean body mass (t = −3.120, β = −0.434, p = 0.003), and handgrip (t = 7.752, β = 1.136, p < 0.001). Our findings demonstrate that sleep quality in adolescent swimmers is a multifactorial result of morphometric characteristics, strength and respiratory function. Full article
23 pages, 5800 KiB  
Article
The Impact of Missing Continuous Blood Glucose Samples on Machine Learning Models for Predicting Postprandial Hypoglycemia: An Experimental Analysis
by Najib Ur Rehman, Ivan Contreras, Aleix Beneyto and Josep Vehi
Mathematics 2024, 12(10), 1567; https://doi.org/10.3390/math12101567 (registering DOI) - 17 May 2024
Abstract
This study investigates how missing data samples in continuous blood glucose data affect the prediction of postprandial hypoglycemia, which is crucial for diabetes management. We analyzed the impact of missing samples at different times before meals using two datasets: virtual patient data and [...] Read more.
This study investigates how missing data samples in continuous blood glucose data affect the prediction of postprandial hypoglycemia, which is crucial for diabetes management. We analyzed the impact of missing samples at different times before meals using two datasets: virtual patient data and real patient data. The study uses six commonly used machine learning models under varying conditions of missing samples, including custom and random patterns reflective of device failures and arbitrary data loss, with different levels of data removal before mealtimes. Additionally, the study explored different interpolation techniques to counter the effects of missing data samples. The research shows that missing samples generally reduce the model performance, but random forest is more robust to missing samples. The study concludes that the adverse effects of missing samples can be mitigated by leveraging complementary and informative non-point features. Consequently, our research highlights the importance of strategically handling missing data, selecting appropriate machine learning models, and considering feature types to enhance the performance of postprandial hypoglycemia predictions, thereby improving diabetes management. Full article
(This article belongs to the Special Issue Artificial Intelligence Solutions in Healthcare)
17 pages, 797 KiB  
Review
Animal Feed Formulation—Connecting Technologies to Build a Resilient and Sustainable System
by Oreofeoluwa Akintan, Kifle G. Gebremedhin and Daniel Dooyum Uyeh
Animals 2024, 14(10), 1497; https://doi.org/10.3390/ani14101497 (registering DOI) - 17 May 2024
Abstract
The unprecedented challenges presented by the increase in global population have placed substantial demands on the livestock industry for human nutrition, necessitating heightened animal productivity and leading to an increased demand for natural resources to produce animal feed. Feed producers are leading the [...] Read more.
The unprecedented challenges presented by the increase in global population have placed substantial demands on the livestock industry for human nutrition, necessitating heightened animal productivity and leading to an increased demand for natural resources to produce animal feed. Feed producers are leading the charge, consistently refining formulations to adapt to the evolving needs of livestock, driven in part by the cost of over 50% associated with feed production. This paper critically analyses the pressing issues within feed formulation, addressing the requirement for environmentally sustainable practices amidst the challenges of climate change. The exploration extends to how advanced decision support tools can enhance formulation techniques and profitability and contribute to environmental sustainability. Through an in-depth review of current feed formulation technologies, encompassing their applications and limitations, this study aims to enhance the existing knowledge base. Additionally, we examined future trends, highlighting the essential role of connecting technologies to establish a resilient and sustainable system. The emphasis is on the potential of formulation techniques to positively impact the environment and enhance the overall quality and performance of the animals. This paper provides actionable insights to improve animal production by examining feed formulation models and decision support tools. The anticipated outcome is a more informed and sustainable decision-making process, addressing the multifaceted challenges confronted by the livestock industry and making contributions to global efforts in climate change mitigation and environmental stewardship in animal production agriculture. Full article
(This article belongs to the Section Animal Nutrition)
12 pages, 405 KiB  
Article
Molecular Screening for Digital Dermatitis-Associated Treponemes in Bovine Ischaemic Teat Necrosis Lesions and Milk in Dairy Cattle
by Hayley E. Crosby-Durrani, Stuart D. Carter, Roger W. Blowey and Nicholas J. Evans
Pathogens 2024, 13(5), 427; https://doi.org/10.3390/pathogens13050427 (registering DOI) - 17 May 2024
Abstract
Bovine ischaemic teat necrosis (ITN) is a disease affecting the skin of the teats of dairy cows with an unknown aetiopathogenesis. Digital dermatitis (DD)-associated treponemes have previously been suggested as a potential aetiological agent in ITN, although the sample size was small. The [...] Read more.
Bovine ischaemic teat necrosis (ITN) is a disease affecting the skin of the teats of dairy cows with an unknown aetiopathogenesis. Digital dermatitis (DD)-associated treponemes have previously been suggested as a potential aetiological agent in ITN, although the sample size was small. The current study, using established PCR techniques, aimed to examine the association with the presence of DD-associated treponemes in a large number of ITN samples from a wider geographical area, and surveyed the potential of milk as an infection reservoir. From 95 ITN lesions, 35.8% (n = 34) were positive for at least one DD-associated treponeme compared with only 5.6% (n = 1) of 18 non-lesioned teats from cows with ITN lesions on a different teat using a nested PCR approach. All 10 age- and production-matched control cows were negative for DD-associated treponemes via PCR. No DD-associated treponemes could be detected from foremilk of cows with (n = 19) and without (n = 31) a DD lesion on the hind feet. DD-associated treponemes could be detected via PCR after incubation in milk for up to 2 h. Therefore, milk does not appear to be a competent reservoir for transmission of DD-associated treponemes. Moreover, in the current study DD-associated treponemes were only detected in a subset of ITN samples, so it is unlikely these opportunistic skin-associated pathogens are the major or sole agent of ITN. Full article
(This article belongs to the Section Bacterial Pathogens)
34 pages, 5744 KiB  
Review
Mapping the Landscape of the Literature on Environmental, Social, Governance Disclosure and Firm Value: A Bibliometric Analysis and Systematic Review
by Chun Cai, Saddam A. Hazaea, Mohammed Hael, Ebrahim Mohammed Al-Matari, Adeeb Alhebri and Abdulmajeed Mawhan H. Alfadhli
Sustainability 2024, 16(10), 4239; https://doi.org/10.3390/su16104239 (registering DOI) - 17 May 2024
Abstract
Increased interest in sustainability and related issues has led to the development of disclosed corporate information on environmental, social, and governance (ESG) issues. Additionally, questions have arisen about whether these disclosures affect the firm’s value. Therefore, we conducted a bibliometric analysis coupled with [...] Read more.
Increased interest in sustainability and related issues has led to the development of disclosed corporate information on environmental, social, and governance (ESG) issues. Additionally, questions have arisen about whether these disclosures affect the firm’s value. Therefore, we conducted a bibliometric analysis coupled with a systematic literature review (SLR) of the current literature in the Scopus database from 2001 to 2023. We utilized VOS viewer, Site Space, and R Studio tools for this analysis. Our findings indicate that the relationship between ESG disclosures and the firm’s value has different effects and that disclosure impacts through various channels, such as increasing stakeholder trust. Moreover, the keyword analysis results before and after 2015 demonstrate significant advancement in the utilization of a theoretical foundation in the literature. Furthermore, China (Country), “Universidad de Salamanca” (University), “Uyar, Ali and García-Sánchez, Isabel-María” (Authors), and “Sustainability” and “Corporate Social Responsibility and Environmental Management” (Journals) were the most contributing and influential in this field. On the other hand, the results revealed six thematic clusters: society, sustainable development, ESG, organization, innovation, and stakeholders. We found promising research paths and emerging themes through content analysis of these clusters, such as sustainability assurance, green innovation, and sustainable development goals (SDGs). This review concludes by providing a roadmap that includes emerging lines of research that can be explored in depth in future studies to promote better and more comprehensive integration to achieve sustainability and maximize firm value. Full article
(This article belongs to the Section Economic and Business Aspects of Sustainability)
25 pages, 2085 KiB  
Article
Size and Shape Selective Classification of Nanoparticles
by Cornelia Damm, Danny Long, Johannes Walter and Wolfgang Peukert
Powders 2024, 3(2), 255-279; https://doi.org/10.3390/powders3020016 - 17 May 2024
Abstract
As nanoparticle syntheses on a large scale usually yield products with broad size and shape distributions, the properties of nanoparticle-based products need to be tuned after synthesis by narrowing the size and shape distributions or via the removal of undesired fractions. The development [...] Read more.
As nanoparticle syntheses on a large scale usually yield products with broad size and shape distributions, the properties of nanoparticle-based products need to be tuned after synthesis by narrowing the size and shape distributions or via the removal of undesired fractions. The development of property-selective classification processes requires a universal framework for the quantitative evaluation of multi-dimensional particle fractionation processes. This framework must be applicable to any property and any particle classification process. We extended the well-known one-dimensional methodology commonly used for describing particle size distributions and fractionation processes to the multi-dimensional case to account for the higher complexity of the property distribution and separation functions. In particular, multi-dimensional lognormal distributions are introduced and applied to diameter and length distributions of gold nanorods. The fractionation of nanorods via centrifugation and by orthogonal centrifugal and electric forces is modeled. Moreover, we demonstrate that analytical ultracentrifugation with a multi-wavelength detector (MWL-AUC) is a fast and very accurate method for the measurement of two-dimensional particle size distributions in suspension. The MWL-AUC method is widely applicable to any class of nanoparticles with size-, shape- or composition-dependent optical properties. In addition, we obtained distributions of the lateral diameter and the number of layers of molybdenum disulfide nanosheets via stepwise centrifugation and spectroscopic evaluation of the size fractions. Full article
13 pages, 472 KiB  
Article
Academic Performance of Excellence: The Impact of Self-Regulated Learning and Academic Time Management Planning
by Abílio Afonso Lourenço and Maria Olímpia Paiva
Knowledge 2024, 4(2), 289-301; https://doi.org/10.3390/knowledge4020016 - 17 May 2024
Abstract
The Program for International Student Assessment highlights the persistent lack of commitment and motivation among students worldwide in their school activities, which are resulting in decreased proficiency levels in reading, mathematics, and science. The magnitude of this phenomenon, with its clear social implications, [...] Read more.
The Program for International Student Assessment highlights the persistent lack of commitment and motivation among students worldwide in their school activities, which are resulting in decreased proficiency levels in reading, mathematics, and science. The magnitude of this phenomenon, with its clear social implications, suggests that we are facing a concerning quest for immediate answers and results. This research focuses on the impact of the relationships between self-regulated learning processes and the planning of time management that is dedicated to school activities on student performance, specifically in the subjects of the Mother Tongue and Mathematics. The instruments used for analysis included the Inventory of Self-Regulated Learning Processes, the Inventory of Time Management Planning, a personal data sheet, and a school data sheet. The sample in this study consisted of 688 students from primary schools in northern Portugal. The results reveal that self-regulated learning has a positive influence on how students plan time management, both in the short and long term. Additionally, a positive and statistically significant relationship is observed between short-term and long-term time management planning and students’ academic performance. This study provides an in-depth perspective on the dynamics between these elements, shedding light on the crucial nuances that shape students’ academic journeys. Full article
12 pages, 37783 KiB  
Article
Microscopic Image Dataset with Segmentation and Detection Labels for Microplastic Analysis in Sewage: Enhancing Research and Environmental Monitoring
by Gwanghee Lee, Jaeheon Jung, Sangjun Moon, Jihyun Jung and Kyoungson Jhang
Microplastics 2024, 3(2), 264-275; https://doi.org/10.3390/microplastics3020016 - 17 May 2024
Abstract
We introduce a novel microscopic image dataset augmented with segmentation and detection labels specifically designed for microplastic analysis in sewage environments. Recognizing the increasing concern over microplastics—particles of synthetic polymers smaller than 5 mm—and their detrimental effects on marine ecosystems and human health, [...] Read more.
We introduce a novel microscopic image dataset augmented with segmentation and detection labels specifically designed for microplastic analysis in sewage environments. Recognizing the increasing concern over microplastics—particles of synthetic polymers smaller than 5 mm—and their detrimental effects on marine ecosystems and human health, our research focuses on enhancing detection and analytical methodologies through advanced computer vision and deep learning techniques. The dataset comprises high-resolution microscopic images of microplastics collected from sewage, meticulously labeled for both segmentation and detection tasks, aiming to facilitate accurate and efficient identification and quantification of microplastic pollution. In addition to dataset development, we present example deep learning models optimized for segmentation and detection of microplastics within complex sewage samples. The models demonstrate significant potential in automating the analysis of microplastic contamination, offering a scalable solution to environmental monitoring challenges. Furthermore, we ensure the accessibility and reproducibility 12 of our research by making the dataset and model codes publicly available, accompanied by detailed 13 documentation on GitHub and LabelBox. Full article
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14 pages, 387 KiB  
Article
Molecular Markers in Melanoma Progression: A Study on the Expression of miRNA Gene Subtypes in Tumoral vs. Benign Nevi
by Mihaela Prodan, Sergiu Costescu, Ahmed Elagez, Sorina Maria Denisa Laitin, Vlad Bloanca, Zorin Crainiceanu, Edward Seclaman, Ana-Olivia Toma, Roxana Manuela Fericean, George Puenea and Gabriel Veniamin Cozma
Curr. Oncol. 2024, 31(5), 2881-2894; https://doi.org/10.3390/curroncol31050220 - 17 May 2024
Abstract
This study investigates the differential expression of miRNA gene subtypes in tumoral versus benign nevi in individuals with melanoma, aiming to identify clinically significant correlations that could serve as reliable markers for assessing tumor stage and progression. Conducted between 2019 and 2022, this [...] Read more.
This study investigates the differential expression of miRNA gene subtypes in tumoral versus benign nevi in individuals with melanoma, aiming to identify clinically significant correlations that could serve as reliable markers for assessing tumor stage and progression. Conducted between 2019 and 2022, this descriptive, quantitative observational research analyzed 90 formalin-fixed paraffin-embedded (FFPE) samples from the Pius Brinzeu County Emergency Clinical Hospital, Timisoara, including 45 samples of advanced-stage melanoma and 45 samples of pigmented nevi. miRNA purification and analysis were performed using the miRNeasy Kit and the Human Cancer PathwayFinder miScript miRNA PCR Array, with statistical analysis (including logistic regression) to determine associations with cancer staging, such as high Breslow index risk, number of mitoses, and vascular invasion. After the analysis and comparison of 180 miRNA gene subtypes, we selected 10 of the most upregulated and 10 most downregulated genes. The results revealed that hsa-miR-133b, hsa-miR-335-5p, hsa-miR-200a-3p, and hsa-miR-885-5p were significantly upregulated in melanoma samples, with fold changes ranging from 1.09 to 1.12. Conversely, hsa-miR-451a and hsa-miR-29b-3p showed notable downregulation in melanoma, with fold changes of 0.90 and 0.92, respectively. Additionally, logistic regression analysis identified hsa-miR-29b-3p (OR = 2.51) and hsa-miR-200a-3p (OR = 2.10) as significantly associated with an increased risk of a high Breslow index, while hsa-miR-127-3p and hsa-miR-451a were associated with a reduced risk. Conclusively, this study underscores the significant alterations in miRNA expression in melanoma compared to benign nevi and highlights the potential of specific miRNAs as biomarkers for melanoma progression. The identification of miRNAs with significant associations to melanoma characteristics suggests their utility in developing non-invasive, cost-effective diagnostic tools and in guiding therapeutic decisions, potentially improving patient outcomes in melanoma management. Full article
(This article belongs to the Special Issue Epidemiology and Risk Factors of Skin Cancer)
31 pages, 2416 KiB  
Article
Investigating and Improving Pedestrian Safety in an Urban Environment of a Low- or Middle-Income Country: A Case Study of Yaoundé, Cameroon
by Steffel Ludivin Tezong Feudjio, Dimitri Tchaheu Tchaheu, Stephen Kome Fondzenyuy, Isaac Ndumbe Jackai II, Davide Shingo Usami and Luca Persia
Future Transp. 2024, 4(2), 548-578; https://doi.org/10.3390/futuretransp4020026 - 17 May 2024
Abstract
In Yaoundé, Cameroon, where walking dominates transport modes, pedestrian safety remains an issue as pedestrians account for a fair share of road traffic casualties, partly due to the lack of walking policies and pedestrian facilities safety data, hindering targeted intervention. This study used [...] Read more.
In Yaoundé, Cameroon, where walking dominates transport modes, pedestrian safety remains an issue as pedestrians account for a fair share of road traffic casualties, partly due to the lack of walking policies and pedestrian facilities safety data, hindering targeted intervention. This study used a pedestrian safety index (PSI) and the Global Walkability Index (GWI) to investigate 12 road segments frequented by diverse pedestrian groups. Indexes were graded from E—lowest to A—highest and analyzed using description and rank correlation. Main safety issues included lack of adequate and accessible sidewalks, bollards, pedestrian crossings, signage, shade, and street lighting. Only one segment (R7) achieved grade C, while the remainder scored D or E, indicating poor pedestrian safety conditions and an unpleasant walking experience. The correlation coefficient (0.69) between the PSI and GWI at a 99% significance level validated the safety assessment, providing confidence in the results. A seven-year (2024–2030) safety strategy is proposed to improve all roads to grade B. This strategy contains several interventions, including engineering improvement, which have been proven effective. This study offers evidence for city officials to improve pedestrian safety and informs walking policies and the implementation of upcoming projects. Future research should quantify the recommendations’ benefits and validate indexes with crash or conflict data. Full article
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19 pages, 3812 KiB  
Article
Evaluation of Tactile and Thermophysiological Comfort in Reusable Surgical Gowns Compared to Disposable Gowns
by Magdalena Georgievska, Abreha Bayrau Nigusse, Benny Malengier, Hasan Riaz Tahir, Charlotte Harding, Sufiyan Derbew Tiku and Lieva Van Langenhove
Textiles 2024, 4(2), 237-255; https://doi.org/10.3390/textiles4020014 - 17 May 2024
Abstract
Though the transition from disposable to reusable surgical gowns holds substantial promise, successful implementation faces challenges. This study investigated tactile and thermophysiological comfort in surgical reusable gowns, comparing them with their disposable counterparts. Parameters such as surface roughness, compression, heat flux, and material [...] Read more.
Though the transition from disposable to reusable surgical gowns holds substantial promise, successful implementation faces challenges. This study investigated tactile and thermophysiological comfort in surgical reusable gowns, comparing them with their disposable counterparts. Parameters such as surface roughness, compression, heat flux, and material rigidity were tested using a Fabric Touch Tester. Additionally, the water vapour permeability and static charge of the gowns were assessed. Thermophysiological comfort of the gowns was evaluated by measuring the temperature and relative humidity (RH) on test subjects during wear trials where they were engaged in an activity that mimics a surgeon’s performance. Skin temperature was monitored using iButton sensors and a thermal camera, and the impact on heart rate during the task was analysed. Following each test, participants provided subjective feedback through a questionnaire. The results indicated that reusable gowns boasted a smoother texture, translating to reduced friction on the skin and better heat transfer compared to the disposable fabrics, as indicated using FTT. They also exhibited higher water vapour permeability compared to their disposable counterparts. The wear trials revealed minimal differences in comfort between disposable and reusable gowns. While performing the activity, an increase in body temperature led to decreased RH, yet this rise did not adversely affect subject comfort, as validated using heart rate and questionnaire survey data. From a comfort point of view, switching from disposable to reusable gowns would not have drawbacks, meaning hospitals should be able to switch provided logistics and costs can be managed. Full article
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16 pages, 1997 KiB  
Article
Feasibility of Using Green Laser for Underwater Infrastructure Monitoring: Case Studies in South Florida
by Rahul Dev Raju, Sudhagar Nagarajan, Madasamy Arockiasamy and Stephen Castillo
Geomatics 2024, 4(2), 173-188; https://doi.org/10.3390/geomatics4020010 - 17 May 2024
Abstract
Scour around bridges present a severe threat to the stability of railroad and highway bridges. Scour needs to be monitored to prevent the bridges from becoming damaged. This research studies the feasibility of using green laser for monitoring the scour around candidate railroad [...] Read more.
Scour around bridges present a severe threat to the stability of railroad and highway bridges. Scour needs to be monitored to prevent the bridges from becoming damaged. This research studies the feasibility of using green laser for monitoring the scour around candidate railroad and highway bridges. The laboratory experiments that provided the basis for using green laser for underwater mapping are also discussed. The results of the laboratory and field experiments demonstrate the feasibility of using green laser for underwater infrastructure monitoring with limitations on the turbidity of water that affects the penetrability of the laser. This method can be used for scour monitoring around offshore structures in shallow water as well as corrosion monitoring of bridges. Full article
26 pages, 5983 KiB  
Article
Geoinformatics-Based Mapping of Environmental Sensitive Areas for Desertification over Satara and Sangli Districts of Maharashtra, India
by Chandra Shekhar Dwivedi, Dishant, Bikash Ranjan Parida, Arvind Chandra Pandey, Ravi Kumar and Navneet Kumar
GeoHazards 2024, 5(2), 415-440; https://doi.org/10.3390/geohazards5020022 - 17 May 2024
Abstract
Desertification processes in arid, semi-arid, and dry sub-humid conditions have been enhanced in recent decades. The geospatial database and associated satellite data can be effectively employed for regional planning to address desertification and land degradation. In this study, the Mediterranean Desertification and Land [...] Read more.
Desertification processes in arid, semi-arid, and dry sub-humid conditions have been enhanced in recent decades. The geospatial database and associated satellite data can be effectively employed for regional planning to address desertification and land degradation. In this study, the Mediterranean Desertification and Land Use (MEDALUS) model has been used to map environmentally sensitive areas due to desertification in the Satara and Sangli districts of Maharashtra, India. This was achieved by combining Landsat-8 multispectral data, Census data, soil data, and climatic variables like temperature, rainfall, and evapotranspiration. The algorithm of MEDALUS is the geometric mean of four indicators, namely soil quality index (SQI), climate quality index (CQI), vegetation quality index (VQI), and socio-economic quality index (SEQI). The findings indicated that the majority of the study area comes under the potential category of desertification (60.32%) followed by fragile (27.87%) and critical (11.81%). Areas with a high propensity for desertification were found over the low to very low climatic quality and moderate to high soil quality including lower socio-economic quality. The lower socio-economic quality is mainly due to high to very high population density (>100 people/km2), low to moderate illiteracy rate (<16%), and low to moderate work participation rate (<50%) that incentivize unsustainable land use practices. The study provides a valuable tool for understanding and managing natural resources. It offers a detailed analysis of the environmental sensitivity of the study area, taking into account various factors like land use, vegetation cover, slope, and soil erosion potential. The developed comprehensive map of the area helps in identifying the most sensitive regions and developing appropriate conservation strategies. The information obtained from the study can be utilized to develop and implement successful measures to prevent or alleviate desertification, which is crucial for sustaining the health of ecosystems and the welfare of local residents. Full article
12 pages, 443 KiB  
Article
Relationship between Maternal Socioeconomic Factors and Preterm Birth in Latvia
by Katrīne Kūkoja, Anita Villeruša and Irisa Zīle-Velika
Medicina 2024, 60(5), 826; https://doi.org/10.3390/medicina60050826 - 17 May 2024
Abstract
Background and Objectives: Worldwide, preterm birth (PTB) stands as the primary cause of mortality among children under 5 years old. Socioeconomic factors significantly impact pregnancy outcomes, influencing both maternal well-being and newborn health. Understanding and addressing these socioeconomic factors is essential for developing [...] Read more.
Background and Objectives: Worldwide, preterm birth (PTB) stands as the primary cause of mortality among children under 5 years old. Socioeconomic factors significantly impact pregnancy outcomes, influencing both maternal well-being and newborn health. Understanding and addressing these socioeconomic factors is essential for developing effective public health interventions and policies aimed at improving pregnancy outcomes. This study aims to analyse the relationship between socioeconomic factors (education level, marital status, place of residence and nationality) and PTB in Latvia, considering mother’s health habits, health status, and pregnancy process. Materials and Methods: A cross-sectional study was conducted using data from the Medical Birth Register (MBR) of Latvia about women with singleton pregnancies in 2022 (n = 15,431). Data analysis, involving crosstabs, chi-square tests, and multivariable binary logistic regression, was performed. Adjusted Odds ratios (aOR) with 95% confidence intervals (CI) were estimated. Results: Lower maternal education was statistically significantly associated with increased odds of PTB. Mothers with education levels below secondary education had over two times higher odds of PTB (aOR = 2.07, p < 0.001, CI 1.58–2.70) and those with secondary or vocational secondary education had one and a half times higher odds (aOR = 1.58, p < 0.001, CI 1.33–1.87) after adjusting for other risk factors. Study results also showed the cumulative effect of socioeconomic risk factors on PTB. Additionally, mothers facing two or three socioeconomic risk factors in Latvia exhibited one and a half times higher odds of PTB (aOR = 1.59, p = 0.021). Conclusions: The study highlights the cumulative impact of socioeconomic risk factors on PTB, with higher maternal education demonstrating the highest protective effect against it. This underscores the importance of education in promoting optimal foetal development. Since the influence of socioeconomic factors on PTB is not a widely studied issue in Latvia, further research is needed to improve understanding of this complex topic. Full article
(This article belongs to the Section Epidemiology & Public Health)
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