The 2023 MDPI Annual Report has
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18 pages, 2832 KiB  
Article
An Explainable Deep Learning Classifier of Bovine Mastitis Based on Whole-Genome Sequence Data—Circumventing the p >> n Problem
by Krzysztof Kotlarz, Magda Mielczarek, Przemysław Biecek, Katarzyna Wojdak-Maksymiec, Tomasz Suchocki, Piotr Topolski, Wojciech Jagusiak and Joanna Szyda
Int. J. Mol. Sci. 2024, 25(9), 4715; https://doi.org/10.3390/ijms25094715 (registering DOI) - 26 Apr 2024
Abstract
The serious drawback underlying the biological annotation of whole-genome sequence data is the p >> n problem, which means that the number of polymorphic variants (p) is much larger than the number of available phenotypic records (n). We propose a way to circumvent [...] Read more.
The serious drawback underlying the biological annotation of whole-genome sequence data is the p >> n problem, which means that the number of polymorphic variants (p) is much larger than the number of available phenotypic records (n). We propose a way to circumvent the problem by combining a LASSO logistic regression with deep learning to classify cows as susceptible or resistant to mastitis, based on single nucleotide polymorphism (SNP) genotypes. Among several architectures, the one with 204,642 SNPs was selected as the best. This architecture was composed of two layers with, respectively, 7 and 46 units per layer implementing respective drop-out rates of 0.210 and 0.358. The classification of the test data resulted in AUC = 0.750, accuracy = 0.650, sensitivity = 0.600, and specificity = 0.700. Significant SNPs were selected based on the SHapley Additive exPlanation (SHAP). As a final result, one GO term related to the biological process and thirteen GO terms related to molecular function were significantly enriched in the gene set that corresponded to the significant SNPs. Our findings revealed that the optimal approach can correctly predict susceptibility or resistance status for approximately 65% of cows. Genes marked by the most significant SNPs are related to the immune response and protein synthesis. Full article
(This article belongs to the Section Molecular Genetics and Genomics)
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16 pages, 13284 KiB  
Article
Screening of Complex Layered Chalcogenide Structures as High-Performance Thermoelectrics by High-Throughput Calculations
by Jing Tian, Weiliang Ma, Manuela Carenzi, Pascal Boulet and Marie-Christine Record
Crystals 2024, 14(5), 403; https://doi.org/10.3390/cryst14050403 (registering DOI) - 26 Apr 2024
Abstract
Thermoelectric materials have drawn much attention over the last two decades due to the increase in global energy demand. However, designing efficient thermoelectrics reveals itself as a tough task for their properties (Seebeck coefficient, electrical conductivity, thermal conductivity) are mutually opposed. Hence, most [...] Read more.
Thermoelectric materials have drawn much attention over the last two decades due to the increase in global energy demand. However, designing efficient thermoelectrics reveals itself as a tough task for their properties (Seebeck coefficient, electrical conductivity, thermal conductivity) are mutually opposed. Hence, most recently, new design approaches have appeared, among which high-throughput methods have been implemented either experimentally or computationally. In this work, a high-throughput computer program has been designed to generate over 4000 structures based on a small set of complex layered chalcogenide compounds taken from the mAIVBVI nA2VB3VI homologous series, where AIV is Ge, AV is Sb and BVI is Te. The computer-generated structures have been investigated using density-functional theory methods, and the electronic and transport properties have been calculated. It has been found, using the quantum theory of atoms in molecules and crystals, that a wide variety of bond types constitutes the bonding network of the structures. All the structures are found to have negative formation energies. Among the obtained final structures, 43 are found with a wide band gap energy (>0.25 eV), 358 with semi-conductor/metal characteristics, and 731 with metallic characteristics. The transport properties calculations, using the Boltzmann equation, reveal that two p-type and 86 n-type structures are potentially promising compounds for thermoelectric applications. Full article
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21 pages, 985 KiB  
Article
Integrating an Ensemble Reward System into an Off-Policy Reinforcement Learning Algorithm for the Economic Dispatch of Small Modular Reactor-Based Energy Systems
by Athanasios Ioannis Arvanitidis and Miltiadis Alamaniotis
Energies 2024, 17(9), 2056; https://doi.org/10.3390/en17092056 (registering DOI) - 26 Apr 2024
Abstract
Nuclear Integrated Energy Systems (NIES) have emerged as a comprehensive solution for navigating the changing energy landscape. They combine nuclear power plants with renewable energy sources, storage systems, and smart grid technologies to optimize energy production, distribution, and consumption across sectors, improving efficiency, [...] Read more.
Nuclear Integrated Energy Systems (NIES) have emerged as a comprehensive solution for navigating the changing energy landscape. They combine nuclear power plants with renewable energy sources, storage systems, and smart grid technologies to optimize energy production, distribution, and consumption across sectors, improving efficiency, reliability, and sustainability while addressing challenges associated with variability. The integration of Small Modular Reactors (SMRs) in NIES offers significant benefits over traditional nuclear facilities, although transferring involves overcoming legal and operational barriers, particularly in economic dispatch. This study proposes a novel off-policy Reinforcement Learning (RL) approach with an ensemble reward system to optimize economic dispatch for nuclear-powered generation companies equipped with an SMR, demonstrating superior accuracy and efficiency when compared to conventional methods and emphasizing RL’s potential to improve NIES profitability and sustainability. Finally, the research attempts to demonstrate the viability of implementing the proposed integrated RL approach in spot energy markets to maximize profits for nuclear-driven generation companies, establishing NIES’ profitability over competitors that rely on fossil fuel-based generation units to meet baseload requirements. Full article
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24 pages, 24671 KiB  
Review
Overview of High-Power and Wideband Radar Technology Development at MIT Lincoln Laboratory
by Michael MacDonald, Mohamed Abouzahra and Justin Stambaugh
Remote Sens. 2024, 16(9), 1530; https://doi.org/10.3390/rs16091530 (registering DOI) - 26 Apr 2024
Abstract
This paper summarizes over 60 years of radar system development at MIT Lincoln Laboratory, from early research on satellite tracking and planetary radar to the present ability to perform the centimeter-resolution imaging of resident space objects and future plans to extend this capability [...] Read more.
This paper summarizes over 60 years of radar system development at MIT Lincoln Laboratory, from early research on satellite tracking and planetary radar to the present ability to perform the centimeter-resolution imaging of resident space objects and future plans to extend this capability to geosynchronous range. Full article
(This article belongs to the Special Issue Radar for Space Observation: Systems, Methods and Applications)
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16 pages, 4211 KiB  
Article
Proteins Involved in Focal Cell Adhesion and Podosome Formation Are Differentially Expressed during Colorectal Tumorigenesis in AOM-Treated Rats
by Ian X. Swain and Adam M. Kresak
Cancers 2024, 16(9), 1678; https://doi.org/10.3390/cancers16091678 (registering DOI) - 26 Apr 2024
Abstract
Colorectal tumorigenesis involves the development of aberrant crypt foci (ACF) or preneoplastic lesions, representing the earliest morphological lesion visible in colon cancer. The purpose of this study was to determine changes in protein expression in carcinogen-induced ACF as they mature and transform into [...] Read more.
Colorectal tumorigenesis involves the development of aberrant crypt foci (ACF) or preneoplastic lesions, representing the earliest morphological lesion visible in colon cancer. The purpose of this study was to determine changes in protein expression in carcinogen-induced ACF as they mature and transform into adenomas. Protein expression profiles of azoxymethane (AOM)-induced F344 rat colon ACF and adenomas were compared at four time points, 4 (control), 8, 16, and 24 weeks post AOM administration (n = 9/group), with time points correlating with induction and transformation events. At each time point, micro-dissected ACF and/or adenoma tissues were analyzed across multiple quantitative two-dimensional (2D-DIGE) gels using a Cy-dye labeling technique and a pooled internal standard to quantify expression changes with statistical confidence. Western blot and subsequent network pathway mapping were used to confirm and elucidate differentially expressed (p ≤ 0.05) proteins, including changes in vinculin (Vcl; p = 0.007), scinderin (Scin; p = 0.02), and profilin (Pfn1; p = 0.01), By determining protein expression changes in ACF as they mature and transform into adenomas, a “baseline” of altered regulatory proteins associated with adenocarcinoma development in this model has been elucidated. These data will enable future studies aimed at biomarker identification and understanding the molecular biology of intestinal tumorigenesis and adenocarcinoma maturation under varying intestinal conditions. Full article
(This article belongs to the Section Molecular Cancer Biology)
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14 pages, 1350 KiB  
Article
Effects of Withania somnifera Extract in Chronically Stressed Adults: A Randomized Controlled Trial
by Srikanta Pandit, Amit K. Srivastav, Tapas K. Sur, Supriyo Chaudhuri, Yan Wang and Tuhin K. Biswas
Nutrients 2024, 16(9), 1293; https://doi.org/10.3390/nu16091293 (registering DOI) - 26 Apr 2024
Abstract
Background: Stress is a known causative factor in modulating cognitive health, which overall well-being and quality of life are dependent on. Long-term stress has been shown to disrupt the balance of the hypothalamic–pituitary–adrenal (HPA) axis. Adaptogens, such as Withania somnifera (ashwagandha), are commonly [...] Read more.
Background: Stress is a known causative factor in modulating cognitive health, which overall well-being and quality of life are dependent on. Long-term stress has been shown to disrupt the balance of the hypothalamic–pituitary–adrenal (HPA) axis. Adaptogens, such as Withania somnifera (ashwagandha), are commonly used in Ayurvedic medicine for stress relief and ameliorating HPA-axis dysfunction. The aim of this study was to support the role of a root and leaf water-extracted ashwagandha extract (WS) in stress reduction by confirming the lowest clinically validated dose for stress management (125 mg/day) in a dose-dependent clinical study in adults with self-reported high stress. Methods: An 8-week, randomized, double-blinded, placebo-controlled study to compare the effects of three different WS extract doses (125, 250 and 500 mg) was performed. A total of 131 adults were enrolled, and 98 were included in the final analysis. Attenuation of chronic stress was measured using the 14-item Perceived Stress Scale (PSS) and biochemical-related stress parameters. Results: We have shown that aqueous WS extract (roots and leaves) safely reduces mild to moderate chronic stress at doses of 125 mg, 250 mg, and 500 mg/day for 8 weeks. Conclusions: Our findings demonstrate the stress-reduction capabilities of this well-characterized aqueous extract of WS (root and leaf) at the low dose of 125 mg/day, in a dose-dependent manner, via the modulation of the HPA axis. Trial registration: This study was registered with the Clinical Trials Registry—India (CTRI) with the registration number: CTRI/2019/11/022100. Full article
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10 pages, 1137 KiB  
Article
Clinical Factors Affecting the Rate of Liver Regeneration in Living Donors after Right Hepatectomy
by Minkyoung Kim, Suk-Won Suh, Eun Sun Lee, Sanggyun Suh, Seung Eun Lee and Yoo Shin Choi
J. Pers. Med. 2024, 14(5), 458; https://doi.org/10.3390/jpm14050458 (registering DOI) - 26 Apr 2024
Abstract
Sufficient liver regeneration after a right hepatectomy is important in living donors for preventing postoperative hepatic insufficiency; however, it differs for each living donor so we investigated the clinical factors affecting the rate of liver regeneration after hepatic resection. This retrospective case–control study [...] Read more.
Sufficient liver regeneration after a right hepatectomy is important in living donors for preventing postoperative hepatic insufficiency; however, it differs for each living donor so we investigated the clinical factors affecting the rate of liver regeneration after hepatic resection. This retrospective case–control study investigated fifty-four living donors who underwent a right hepatectomy from July 2015 to March 2023. Patients were classified into 2 groups by the remnant/total volume ratio (RTVR): Group A (RTVR < 30%, n = 9) and Group B (RTVR ≥ 30%, n = 45). The peak postoperative level of total bilirubin was more elevated in Group A than in Group B (3.0 ± 1.1 mg/dL vs. 2.3 ± 0.8 mg/dL, p = 0.046); however, no patients had hepatic insufficiency or major complications. The rates of residual liver volume (RLV) growth at Postoperative Week 1 (89.1 ± 26.2% vs. 53.5 ± 23.7%, p < 0.001) were significantly greater in Group A, and its significant predictors were RTVR (β = −0.478, p < 0.001, variance inflation factor (VIF) = 1.188) and intraoperative blood loss (β = 0.247, p = 0.038, VIF = 1.182). In conclusion, as the RLV decreases, compensatory liver regeneration after hepatic resection becomes more prominent, resulting in comparable operative outcomes. Further studies are required to investigate the relationship between hematopoiesis and the rate of liver regeneration. Full article
(This article belongs to the Special Issue Personalized Medicine in Organ Transplantation 2nd Edition)
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14 pages, 5036 KiB  
Article
The Comminution of Chert Gravel by Microwave Irradiation
by Mark Tzibulsky and Vladimir Frid
Resources 2024, 13(5), 63; https://doi.org/10.3390/resources13050063 (registering DOI) - 26 Apr 2024
Abstract
Chert, a by-product rock of sand quarrying, has historically posed economic challenges for aggregate production, resulting in significant “waste” accumulation in quarries. Our study investigates the effect of microwave irradiation on the mechanical properties of chert gravel, a mineralogically homogenous material composed of [...] Read more.
Chert, a by-product rock of sand quarrying, has historically posed economic challenges for aggregate production, resulting in significant “waste” accumulation in quarries. Our study investigates the effect of microwave irradiation on the mechanical properties of chert gravel, a mineralogically homogenous material composed of fine quartz grains. The results, which demonstrate that increased irradiation time leads to a substantial decrease in chert gravel strength (by a factor of 4–6 for 2.5 min of irradiation), underscore the potential impact of this research on comminution processes. With quenching altering the fractional content of the samples after the crushing test, reducing the Gravel-to-Sand ratio, this study is driven by the promising potential of crushed chert gravel as a pivotal aggregate within the concrete and asphalt industries, offering a practical solution to their material needs. The urgent need to rehabilitate previously utilized quarry areas, offering an environmentally beneficial solution for which we all should be responsible, motivated the present study. Full article
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17 pages, 1351 KiB  
Article
Palladium-Catalyzed Esterification of Aryl Fluorosulfates with Aryl Formates
by Xue Chen, Yuan Liang, Wen-Wen Wang, Chengping Miao, Xue-Qiang Chu, Weidong Rao, Hao Xu, Xiaocong Zhou and Zhi-Liang Shen
Molecules 2024, 29(9), 1991; https://doi.org/10.3390/molecules29091991 (registering DOI) - 26 Apr 2024
Abstract
An efficient palladium-catalyzed carbonylation of aryl fluorosulfates with aryl formates for the facile synthesis of esters was developed. The cross-coupling reactions proceeded effectively in the presence of a palladium catalyst, phosphine ligand, and triethylamine in DMF to produce the corresponding esters in moderate [...] Read more.
An efficient palladium-catalyzed carbonylation of aryl fluorosulfates with aryl formates for the facile synthesis of esters was developed. The cross-coupling reactions proceeded effectively in the presence of a palladium catalyst, phosphine ligand, and triethylamine in DMF to produce the corresponding esters in moderate to good yields. Of note, functionalities or substituents, such as nitro, cyano, methoxycarbonyl, trifluoromethyl, methylsulfonyl, trifluoromethoxy, fluoro, chloro, bromo, methyl, methoxy, N,N-dimethyl, and [1,3]dioxolyl, were well-tolerated in the reactions, which could be kept for late-stage modification. The reactions employing readily available and relatively robust aryl fluorosulfates as coupling electrophiles could potentially serve as an attractive alternative to traditional cross-couplings with the use of aryl halides and pseudohalides as substrates. Full article
(This article belongs to the Section Organic Chemistry)
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19 pages, 5330 KiB  
Article
Dual Deletion of Keap1 and Rbpjκ Genes in Liver Leads to Hepatomegaly and Hypercholesterolemia
by Nobunao Wakabayashi, Yoko Yagishita, Tanvi Joshi and Thomas W. Kensler
Int. J. Mol. Sci. 2024, 25(9), 4712; https://doi.org/10.3390/ijms25094712 (registering DOI) - 26 Apr 2024
Abstract
The hepatic deletion of Rbpjκ (RbpjF/F::AlbCre) in the mouse leads to exhibition of the Alagille syndrome phenotype during early postnatal liver development with hyperlipidemia and cholestasis due to attenuated disruption of NOTCH signaling. Given the roles of NRF2 signaling [...] Read more.
The hepatic deletion of Rbpjκ (RbpjF/F::AlbCre) in the mouse leads to exhibition of the Alagille syndrome phenotype during early postnatal liver development with hyperlipidemia and cholestasis due to attenuated disruption of NOTCH signaling. Given the roles of NRF2 signaling in the regulation of lipid metabolism and bile ductal formation, it was anticipated that these symptoms could be alleviated by enhancing NRF2 signaling in the RbpjF/F::AlbCre mouse by hepatic deletion of Keap1 in compound Keap1F/F::RbpjF/F::AlbCre mice. Unexpectedly, these mice developed higher hepatic and plasma cholesterol levels with more severe cholestatic liver damage during the pre-weaning period than in the RbpjF/F::AlbCre mice. In addition, hypercholesterolemia and hepatic damage were sustained throughout the growth period unlike in the RbpjF/F::AlbCre mouse. These enhanced abnormalities in lipid metabolism appear to be due to NRF2-dependent changes in gene expression related to cholesterol synthetic and subsequent bile acid production pathways. Notably, the hepatic expression of Cyp1A7 and Abcb11 genes involved in bile acid homeostasis was significantly reduced in Keap1F/F::RbpjF/F::AlbCre compared to RbpjF/F::AlbCre mice. The accumulation of liver cholesterol and the weakened capacity for bile excretion during the 3 pre-weaning weeks in the Keap1F/F::RbpjF/F::AlbCre mice may aggravate hepatocellular damage level caused by both excessive cholesterol and residual bile acid toxicity in hepatocytes. These results indicate that a tuned balance of NOTCH and NRF2 signaling is of biological importance for early liver development after birth. Full article
(This article belongs to the Special Issue The Role of NRF2 in Health and Disease)
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18 pages, 5573 KiB  
Article
Effects of Illumination Conditions on Individual Tree Height Extraction Using UAV LiDAR: Pilot Study of a Planted Coniferous Stand
by Tianxi Li, Jiayuan Lin, Wenjian Wu and Rui Jiang
Forests 2024, 15(5), 758; https://doi.org/10.3390/f15050758 (registering DOI) - 26 Apr 2024
Abstract
Tree height is one of the key dendrometric parameters for indirectly estimating the timber volume or aboveground biomass of a forest. Field measurement is time-consuming and labor-intensive, while unmanned aerial vehicle (UAV)-borne LiDAR is a more efficient tool for acquiring tree heights of [...] Read more.
Tree height is one of the key dendrometric parameters for indirectly estimating the timber volume or aboveground biomass of a forest. Field measurement is time-consuming and labor-intensive, while unmanned aerial vehicle (UAV)-borne LiDAR is a more efficient tool for acquiring tree heights of large-area forests. Although individual tree heights extracted from point cloud data are of high accuracy, they are still affected by some weather and environment factors. In this study, taking a planted M. glyptostroboides (Metasequoia glyptostroboides Hu & W.C. Cheng) stand as the study object, we preliminarily assessed the effects of various illumination conditions (solar altitude angle and cloud cover) on tree height extraction using UAV LiDAR. The eight point clouds of the target stand were scanned at four time points (sunrise, noon, sunset, and night) in two consecutive days (sunny and overcast), respectively. The point clouds were first classified into ground points and aboveground vegetation points, which accordingly produced digital elevation model (DEM) and digital surface model (DSM). Then, the canopy height model (CHM) was obtained by subtracting DEM from DSM. Subsequently, individual trees were segmented based on the seed points identified by local maxima filtering. Finally, the individual tree heights of sample trees were separately extracted and assessed against the in situ measured values. As results, the R2 and RMSEs of tree heights obtained in the overcast daytime were commonly better than those in the sunny daytime; the R2 and RMSEs at night were superior among all time points, while those at noon were poorest. These indicated that the accuracy of individual tree height extraction had an inverse correlation with the intensity of illumination. To obtain more accurate tree heights for forestry applications, it is best to acquire point cloud data using UAV LiDAR at night, or at least not at noon when the illumination is generally strongest. Full article
(This article belongs to the Topic Individual Tree Detection (ITD) and Its Applications)
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16 pages, 2119 KiB  
Article
The Effect of High-Pressure Processing of Caprine Milk on the Production and Properties of Yoghurt
by Agnieszka Jankowska, Katarzyna Kiełczewska, Maria Wachowska, Aneta Dąbrowska, Krzysztof Siemianowski, Elżbieta Haponiuk and Katarzyna Stasiewicz
Foods 2024, 13(9), 1327; https://doi.org/10.3390/foods13091327 (registering DOI) - 26 Apr 2024
Abstract
The aim of this study was to determine the suitability of HP-treated caprine milk for yoghurt production and to evaluate the effect of HP treatment on yoghurt properties. Reconstituted caprine milk was subjected to HP treatment (350 MPa/10 min/20 °C); a lactic acid [...] Read more.
The aim of this study was to determine the suitability of HP-treated caprine milk for yoghurt production and to evaluate the effect of HP treatment on yoghurt properties. Reconstituted caprine milk was subjected to HP treatment (350 MPa/10 min/20 °C); a lactic acid starter culture (YC-X16, Chr. Hansen) was added. Milk was fermented at a temperature of 43 °C until pH 4.60. Bacterial counts, pH, color, rheological characteristics, texture, microstructure, and the sensory attributes of the yoghurt were determined after production and after seven days of storage at a temperature of 4 °C. HP treatment increased color saturation and whiteness index and induced a minor increase in milk pH. Minor differences in the acidification curve were noted. During storage, Streptococcus thermophilus counts were significantly higher in yoghurt from HP-treated than from untreated milk, whereas Lactobacillus delbruecki ssp. bulgaricus counts remained stable. A color analysis did not reveal differences between the experimental and control yoghurts. After storage, yoghurt made from HP-treated milk was characterized by thicker consistency and lower rheological stability than the control yoghurt. The micrographs of the yoghurts confirmed the differences in rheological parameters. Yoghurt produced from HP-treated caprine milk and stored for seven days received the highest scores in the sensory evaluation. Full article
(This article belongs to the Section Dairy)
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11 pages, 590 KiB  
Article
Platelet-Rich Plasma Injections in Chronic Lateral Ankle Instability: A Case Series
by Ivan Medina-Porqueres, Pablo Martin-Garcia, Sofia Sanz-De-Diego, Marcelo Reyes-Eldblom, Francisco Moya-Torrecilla, Rafael Mondragon-Cortes, Daniel Rosado-Velazquez and Abel Gomez-Caceres
Biomedicines 2024, 12(5), 963; https://doi.org/10.3390/biomedicines12050963 (registering DOI) - 26 Apr 2024
Abstract
The platelet-rich plasma (PRP) approach may be an effective treatment for joint and cartilage pathologies. However, the rationale for its effectiveness on joint instability is limited. This study aimed to assess the safety and effectiveness of PRP injections in patients with chronic lateral [...] Read more.
The platelet-rich plasma (PRP) approach may be an effective treatment for joint and cartilage pathologies. However, the rationale for its effectiveness on joint instability is limited. This study aimed to assess the safety and effectiveness of PRP injections in patients with chronic lateral ankle instability (CLAI). This retrospective study was performed at a single-center outpatient clinic between January 2015 and February 2023 and included pre-intervention assessment and short-term follow-up. Patients were excluded if they had received previous surgical treatment or had constitutional hyperlaxity, systemic diseases, or grade II or III osteoarthritis. The clinical and functional evaluation consisted of the Karlsson score, the Cumberland Ankle Instability Tool (CAIT), Good’s grading system, the patient’s subjective satisfaction level, and the time required to return to exercise. The entire PRP therapy regime consisted of three PRP administrations at 7-day intervals and follow-up appointments. PRP was administered both intraarticularly and into talofibular ligaments. A total of 47 consecutive patients with CLAI were included, 11 were female (23.4%), with a mean age at intervention of 31.19 ± 9.74 years. A statistically significant improvement was found in the CAIT and Karlsson scores at 3 months (27.74 ± 1.68 and 96.45 ± 4.28, respectively) relative to the pre-intervention status (10.26 ± 4.33 and 42.26 ± 14.9, respectively, p < 0.000). The mean follow-up of patients with CLAI was 17.94 ± 3.25 weeks. This study represents successful short-term functional and clinical outcomes in patients with CLAI after PRP treatment, with no adverse effects. It demonstrates the feasibility of a randomized controlled trial to further assess this therapy. Full article
(This article belongs to the Special Issue Musculoskeletal Regenerative Medicine)
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22 pages, 4413 KiB  
Article
Thermal Stability, Durability, and Service Life Estimation of Woven Flax-Carbon Hybrid Polyamide Biocomposites
by Mohsen Bahrami, Juana Abenojar, Gladis M. Aparicio and Miguel Angel Martínez
Materials 2024, 17(9), 2020; https://doi.org/10.3390/ma17092020 (registering DOI) - 26 Apr 2024
Abstract
Woven flax-carbon hybrid polyamide biocomposites offer a blend of carbon fibers’ mechanical strength and flax’s environmental advantages, potentially developing material applications. This study investigated their thermal behavior, degradation kinetics, and durability to water uptake and relative humidity exposure and compared them with pure [...] Read more.
Woven flax-carbon hybrid polyamide biocomposites offer a blend of carbon fibers’ mechanical strength and flax’s environmental advantages, potentially developing material applications. This study investigated their thermal behavior, degradation kinetics, and durability to water uptake and relative humidity exposure and compared them with pure flax and carbon composites with the same matrix. The hybrid composite exhibited intermediate water/moisture absorption levels between pure flax and carbon composites, with 7.2% water absorption and 3.5% moisture absorption. It also displayed comparable thermal degradation resistance to the carbon composite, effectively maintaining its weight up to 300 °C. Further analysis revealed that the hybrid composite exhibited a decomposition energy of 268 kJ/mol, slightly lower than the carbon composite’s value of 288.5 kJ/mol, indicating similar thermal stability. Isothermal lifetime estimation, employing the activation energy (Ed) and degree of conversion facilitated by the Model Free Kinetics method, indicated a 41% higher service life of the hybrid laminate at room temperature compared to the carbon laminate. These insights are crucial for understanding the industrial applications of these materials without compromising durability. Full article
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23 pages, 6742 KiB  
Article
A Cost-Effective Integrated Methodology for Electromagnetic Actuation via Visual Feedback
by Shuwan Chen, Damiano Padovani, Andrea Cioncolini and Angelo Alessandri
Sensors 2024, 24(9), 2760; https://doi.org/10.3390/s24092760 (registering DOI) - 26 Apr 2024
Abstract
Electromagnetic actuation can support many fields of technology, such as robotics or biomedical applications. In this context, fully understanding the system behavior and proposing a low-cost package for feedback control is challenging. Modeling the electromagnetic force is particularly tricky because it is a [...] Read more.
Electromagnetic actuation can support many fields of technology, such as robotics or biomedical applications. In this context, fully understanding the system behavior and proposing a low-cost package for feedback control is challenging. Modeling the electromagnetic force is particularly tricky because it is a nonlinear function of the actuated object’s position and coil’s current. Measuring in real time the position of the actuated object with the precision required for accurate motion control is also nontrivial. In this study, we propose a novel, cost-effective electromagnetic set-up to achieve position control via visual feedback. We actuated vertically and under different experimental conditions a 10 mm diameter steel ball hanging on a low-stiffness spring, demonstrating good tracking performance (the position error remained within ±0.5 mm, with a negligible phase delay in the best scenarios). The experimental results confirm the feasibility of the proposed set-up, which is characterized by minimum complexity and realized with off-the-shelf and cost-effective components. For these reasons, such a contribution helps to understand and apply electromagnetic actuation even further. Full article
(This article belongs to the Section Navigation and Positioning)
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17 pages, 3669 KiB  
Article
DBO-CNN-BiLSTM: Dung Beetle Optimization Algorithm-Based Thrust Estimation for Micro-Aero Engine
by Baijun Lei, Haozhong Huang, Guixin Chen, Jianguo Liang and Huigui Long
Aerospace 2024, 11(5), 344; https://doi.org/10.3390/aerospace11050344 (registering DOI) - 26 Apr 2024
Abstract
Thrust constitutes a pivotal performance parameter for aircraft engines. Thrust, being an indispensable parameter in control systems, has garnered significant attention, prompting numerous scholars to propose various methods and algorithms for its estimation. However, research methods for estimating the thrust of the micro-turbojet [...] Read more.
Thrust constitutes a pivotal performance parameter for aircraft engines. Thrust, being an indispensable parameter in control systems, has garnered significant attention, prompting numerous scholars to propose various methods and algorithms for its estimation. However, research methods for estimating the thrust of the micro-turbojet engines used in unmanned aerial vehicles are relatively scarce. Therefore, this paper proposes a thrust estimator for micro-turbojet engines based on DBO (dung beetle optimization) utilizing bidirectional long short-term memory (BiLSTM) and a convolutional neural network (CNN). Furthermore, the efficacy of the proposed model is further validated through comparative analysis with others in this paper. Full article
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18 pages, 1533 KiB  
Systematic Review
Closing the Gap: The Tripartite Structure of Sustainability as a Tool for Sustainable Education—A Systematic Literature Review
by Barbara E. Meyer, Elena Gaertner and Christian Elting
Sustainability 2024, 16(9), 3622; https://doi.org/10.3390/su16093622 (registering DOI) - 26 Apr 2024
Abstract
(1) In an era where sustainable behavior is increasingly crucial, understanding the discrepancy between individuals’ sustainability-oriented values and their actual behaviors, known as the inner–outer gap, is vital. This systematic literature review explores the potential of the Tripartite Structure of Sustainability (TSS) framework [...] Read more.
(1) In an era where sustainable behavior is increasingly crucial, understanding the discrepancy between individuals’ sustainability-oriented values and their actual behaviors, known as the inner–outer gap, is vital. This systematic literature review explores the potential of the Tripartite Structure of Sustainability (TSS) framework to address this gap within the context of sustainable education. By reviewing the literature from the APA, ERIC, and Web of Science databases, searched on 25 October 2020, the factors influencing sustainable actions were systematically examined. Articles had to be relevant to the topic (sustainability, morality in relation to sustainability, or morality in general) and report on empirically validated factors that have an impact on the inner-outer gap. (2) By employing a qualitative content analysis approach, 56 articles over a 15-year period were analyzed, identifying 83 factors that either bridged or reinforced the inner–outer gap. These factors were categorized within the TSS framework, which segments sustainability-oriented actions into individual, social, and self-transcendent domains, alongside their activation points: stable, situational, or automated. (3) The analysis revealed that self-focused factors often reinforce the gap, suggesting they are a hindrance to sustainable behavior. Conversely, self-transcendent factors consistently bridged the gap, promoting sustainability. Social factors showed variable impacts based on the ethical and sustainable context they were placed in, suggesting that the social environment’s orientation significantly influences sustainable behavior. (4) This study concludes that the TSS framework offers a promising approach to advancing education for sustainable development (ESD) and contributes insights into how to promote the required paradigm shift towards holistic and interconnected perspectives. Full article
(This article belongs to the Section Sustainable Education and Approaches)
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21 pages, 13150 KiB  
Article
A Comprehensive Resource Assessment for Wind Power Generation on the Rural Island of Sibuyan, Philippines
by Jerome G. Gacu, Junrey D. Garcia, Eddie G. Fetalvero, Merian P. Catajay-Mani, Cris Edward F. Monjardin and Christopher Power
Energies 2024, 17(9), 2055; https://doi.org/10.3390/en17092055 (registering DOI) - 26 Apr 2024
Abstract
Amid rising energy demands in rural areas, thorough resource assessments for initiatives such as wind power are crucial. This study involves a land resource assessment for wind power generation on the rustic Sibuyan Island in the Philippines, which is currently experiencing an electricity [...] Read more.
Amid rising energy demands in rural areas, thorough resource assessments for initiatives such as wind power are crucial. This study involves a land resource assessment for wind power generation on the rustic Sibuyan Island in the Philippines, which is currently experiencing an electricity shortage. A comprehensive overview of the island’s suitability for wind energy projects is performed via evaluation and analysis using geospatial data and multi-criteria decision making (MCDM). The research results indicate that 50.44% (220.68 km2) of the island’s land area is categorized as ‘poorly suitable’ since it considers protected areas where developments are not allowed. Only 0.08% (0.35 km2) of the island can be classified as ‘marginally suitable’, while 9.15% (40.73 km2), 36.64% (176.39 km2), and 0.69% (3.05 km2) are labeled as ‘moderately suitable’, ‘suitable’, and ‘highly suitable’, respectively. This confirms the potential for wind energy exploration on the island. Delineating the suitability levels provides a foundational framework for stakeholders that enables them to identify optimal sites for wind power, sustain the island’s resources, and contribute to the renewable energy landscape of this rural location. Overall, this study, underpinned by data analysis, offers invaluable insights for decision making in wind power development, with the presented framework adaptable to other areas of interest. Full article
(This article belongs to the Special Issue Wind Turbines, Wind Farms, and Wind Energy: 2nd Edition)
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14 pages, 530 KiB  
Article
Expression of Selected miRNAs in Undifferentiated Carcinoma with Osteoclast-like Giant Cells (UCOGC) of the Pancreas: Comparison with Poorly Differentiated Pancreatic Ductal Adenocarcinoma
by Alexey Popov, Jan Hrudka, Arpád Szabó, Martin Oliverius, Zdeněk Šubrt, Jana Vránová, Vanda Ciprová, Jana Moravcová and Václav Mandys
Biomedicines 2024, 12(5), 962; https://doi.org/10.3390/biomedicines12050962 (registering DOI) - 26 Apr 2024
Abstract
Undifferentiated carcinoma with osteoclast-like giant cells (UCOGC) of the pancreas represents a rare subtype of pancreatic ductal adenocarcinoma (PDAC). Despite a distinct morphology and specific clinical behavior, UCOGCs exhibit unexpected similarities in regard to DNA mutational profiles with conventional PDAC. Treating pancreatic ductal [...] Read more.
Undifferentiated carcinoma with osteoclast-like giant cells (UCOGC) of the pancreas represents a rare subtype of pancreatic ductal adenocarcinoma (PDAC). Despite a distinct morphology and specific clinical behavior, UCOGCs exhibit unexpected similarities in regard to DNA mutational profiles with conventional PDAC. Treating pancreatic ductal adenocarcinoma is particularly challenging, with limited prospects for cure. As with many other malignant neoplasms, the exploration of microRNAs (miRNAs, miRs) in regulating the biological characteristics of pancreatic cancer is undergoing extensive investigation to enhance tumor diagnostics and unveil the therapeutic possibilities. Herein, we evaluated the expression of miR-21, -96, -148a, -155, -196a, -210, and -217 in UCOGCs and poorly differentiated (grade 3, G3) PDACs. The expression of miR-21, miR-155, and miR-210 in both UCOGCs and G3 PDACs was significantly upregulated compared to the levels in normal tissue, while the levels of miR-148a and miR-217 were downregulated. We did not find any significant differences between cancerous and normal tissues for the expression of miR-96 and miR-196a in G3 PDACs, whereas miR-196a was slightly, but significantly, downregulated in UCOGCs. On the other hand, we have not observed significant differences in the expression of the majority of miRNAs between UCOGC and G3 PDAC, with the exception of miR-155. UCOGC samples demonstrated lower mean levels of miR-155 in comparison with those in G3 PDACs. Full article
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25 pages, 2348 KiB  
Article
Resource Scheduling Optimization of Fresh Food Delivery Porters Considering Ambient Temperature Variations
by Ziyu Shan and Jianming Yao
Sustainability 2024, 16(9), 3624; https://doi.org/10.3390/su16093624 (registering DOI) - 26 Apr 2024
Abstract
In the context of an evolving socio-economic landscape and rising living standards, the online market for fresh products, encompassing fruits, vegetables, meats, dairy, and eggs, has seen substantial growth, necessitating sophisticated logistics for e-commerce home delivery. This study tackles the distinct challenges of [...] Read more.
In the context of an evolving socio-economic landscape and rising living standards, the online market for fresh products, encompassing fruits, vegetables, meats, dairy, and eggs, has seen substantial growth, necessitating sophisticated logistics for e-commerce home delivery. This study tackles the distinct challenges of fresh product delivery, which demand rigorous adherence to climate conditions and product mix during transport, significantly influencing the operational strategies and scheduling of delivery platforms. To address these challenges, a comprehensive mathematical model was developed to optimize fresh food home delivery scheduling, focusing on reducing spoilage rates and accommodating the dynamic impact of environmental temperature changes. The model posits assumptions of a consistent and ample supply of fresh goods, standard initial quality loss, and efficient porter assignment for multi-category order combinations. It introduces three objective functions, targeting the minimization of fresh food loss, maximization of customer satisfaction, and reduction of distributor costs. The efficacy of the model and its genetic-algorithm-based solution method was assessed through numerical analysis and case studies, illustrating that the model enhances delivery efficiency and service quality across varying temperature conditions. This substantiates the critical role of environmental temperature management in optimizing fresh food delivery, offering a robust framework for advancing logistical operations in the perishable goods sector and ensuring quality and efficiency in fresh food e-commerce delivery. Full article
(This article belongs to the Section Energy Sustainability)
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11 pages, 1831 KiB  
Article
Multi-Magnet Cochlear-Implant Technology and Magnetic Resonance Imaging: The Safety Issue
by Pietro Canzi, Elena Carlotto, Elisabetta Zanoletti, Johan H. M. Frijns, Daniele Borsetto, Antonio Caruso, Luisa Chiapparini, Andrea Ciorba, Giorgio Conte, Nathan Creber, Stefania Criscuolo, Filippo Di Lella, Sebastiano Franchella, Erik F. Hensen, Lorenzo Lauda, Stefano Malpede, Marco Mandalà, Liselotte J. C. Rotteveel, Anna Simoncelli, Anna Chiara Stellato, Diego Zanetti and Marco Benazzoadd Show full author list remove Hide full author list
Audiol. Res. 2024, 14(3), 401-411; https://doi.org/10.3390/audiolres14030034 (registering DOI) - 26 Apr 2024
Abstract
Despite the spread of novel-generation cochlear-implant (CI) magnetic systems, access to magnetic resonance imaging (MRI) for CI recipients is still limited due to safety concerns. The aim of this study is to assess and record the experiences of Hires Ultra 3D (Advanced Bionics) [...] Read more.
Despite the spread of novel-generation cochlear-implant (CI) magnetic systems, access to magnetic resonance imaging (MRI) for CI recipients is still limited due to safety concerns. The aim of this study is to assess and record the experiences of Hires Ultra 3D (Advanced Bionics) recipients who underwent an MRI examination. A multicentric European survey about this topic was conducted focusing on safety issues, and the results were compared with the current literature. We collected a total of 65 MRI scans performed in 9 otologic referral centers for a total of 47 Hires Ultra 3D recipients, including, for the first time, 2 children and 3 teenagers. Preventive measures were represented by scanning time and sedation for children. Head wrapping was used in eight cases, and six of the eight cases received local anesthesia, even if both measures were not needed. Only three patients complained of pain (3/65 examinations, 4.6%) due to the tight head bandage, and one of the three cases required MRI scan interruption. No other adverse events were reported. We believe that these results should encourage MRI execution in accordance with manufacturer recommendations for Ultra 3D recipients. Full article
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18 pages, 10223 KiB  
Article
Chitosan Oligosaccharides Mitigate Flooding Stress Damage in Rice by Affecting Antioxidants, Osmoregulation, and Hormones
by Haoyu Lu, Mei Wang, Shangfeng Zhou, Ke Chen, Lifeng Wang, Zhenxie Yi, Lianyang Bai and Yuzhu Zhang
Antioxidants 2024, 13(5), 521; https://doi.org/10.3390/antiox13050521 (registering DOI) - 26 Apr 2024
Abstract
Rice (Oryza sativa L.) is one of the most important food crops worldwide. However, during direct seeding, rice is extremely vulnerable to flooding stress, which impairs rice’s emergence and seedling growth and results in a significant yield loss. According to our research, [...] Read more.
Rice (Oryza sativa L.) is one of the most important food crops worldwide. However, during direct seeding, rice is extremely vulnerable to flooding stress, which impairs rice’s emergence and seedling growth and results in a significant yield loss. According to our research, chitosan oligosaccharides have the potential to be a chemical seed-soaking agent that greatly increases rice’s resistance to flooding. Chitosan oligosaccharides were able to enhance seed energy supply, osmoregulation, and antioxidant capacity, according to physiological index assessments. Using transcriptome and metabolomic analysis, we discovered that important differential metabolites and genes were involved in the signaling pathway for hormone synthesis and antioxidant capacity. Exogenous chitosan oligosaccharides specifically and significantly inhibit genes linked to auxin, jasmonic acid, and abscisic acid. This suggested that applying chitosan oligosaccharides could stabilize seedling growth and development by controlling associated hormones and reducing flooding stress by enhancing membrane stability and antioxidant capacity. Finally, we verified the effectiveness of exogenous chitosan oligosaccharides imbibed in seeds by field validation, demonstrating that they can enhance rice seedling emergence and growth under flooding stress. Full article
(This article belongs to the Special Issue Antioxidant Mechanisms and Redox Signalling in Seeds)
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14 pages, 1469 KiB  
Article
Distribution Characteristics of Low-Molecular-Weight Organic Acids in Reclaimed Soil Filled with Fly Ash: A Study
by Yonghong Zheng, Yue Wu, Zhiguo Zhang, Fangling Chen, Qingbin Ma, Zihao Kong and Ying Ma
Toxics 2024, 12(5), 312; https://doi.org/10.3390/toxics12050312 (registering DOI) - 26 Apr 2024
Abstract
This study aims to assess the contents of different kinds of low-molecular-weight organic acids (LMWOAs) in reclaimed soil filled with fly ash in the Huainan mining area in China using high-performance liquid chromatography (HPLC). Using a mobile phase consisting of 0.1% phosphoric acid [...] Read more.
This study aims to assess the contents of different kinds of low-molecular-weight organic acids (LMWOAs) in reclaimed soil filled with fly ash in the Huainan mining area in China using high-performance liquid chromatography (HPLC). Using a mobile phase consisting of 0.1% phosphoric acid and acetonitrile in a volume ratio of 98:2, the detection was performed at a wavelength of 210 nm for 15 min. In addition, a cluster analysis was performed on the detected LMWOAs in the reclaimed soil. The correlations between the LMWOA and nutrient contents in the reclaimed soil were also analyzed. In total, eight and seven LMWOAs were detected in the reclaimed soil and filled fly ash, respectively. In contrast, no LMWOAs were detected in the fresh fly ash from a thermal power plant. The order of total LMWOA contents at different sampling points followed the order of farmland control soil > 1# (Triticum aestivum) > 4# (Phragmites australis) > 5# (Vigna radiata) > 2# (Sorghum bicolor) > 3# (Tamarix ramosissima) > fly ash-filled soil. The farmland control soil and fly ash-filled soil exhibited the highest and lowest LMWOA contents of 648.22 and 85.09 μg·g−1, respectively. The LMWOA contents in the reclaimed soil followed the order of oxalic acid > tartaric acid > malonic acid > lactic acid > acetic acid > citric acid > propionic acid > succinic acid. Indeed, oxalic acids exhibited the highest total amount of 1445.79 μg·g−1 and succinic acids exhibited the lowest total amount of 6.50 μg·g−1. The LMWOA contents in the reclaimed soil decreased with increasing soil depth, showing statistically significant differences between the 0–10 and 10–40 cm soil layers (p < 0.05). According to the obtained clustering results, the detected LMWOAs can be divided into two categories. The first category consisted of oxalic acid, while the second category included the remaining LMWOAs. The soil LMWOA contents of 4# (Phragmites australis) and 5# (Vigna radiata) were significantly different from those at the other sampling points. According to the Pearson correlation analysis results, the occurrence and characteristics of the soil LMWOAs can be controlled by regulating the pH values and available nutrient contents in the soil, thereby improving the eco-environmental conditions of the reclaimed rhizosphere. Full article
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