The 2023 MDPI Annual Report has
been released!
 
14 pages, 1350 KiB  
Article
Effects of Withania somnifera Extract in Chronically Stressed Adults: A Randomized Controlled Trial
by Srikanta Pandit, Amit K. Srivastav, Tapas K. Sur, Supriyo Chaudhuri, Yan Wang and Tuhin K. Biswas
Nutrients 2024, 16(9), 1293; https://doi.org/10.3390/nu16091293 (registering DOI) - 26 Apr 2024
Abstract
Background: Stress is a known causative factor in modulating cognitive health, which overall well-being and quality of life are dependent on. Long-term stress has been shown to disrupt the balance of the hypothalamic–pituitary–adrenal (HPA) axis. Adaptogens, such as Withania somnifera (ashwagandha), are commonly [...] Read more.
Background: Stress is a known causative factor in modulating cognitive health, which overall well-being and quality of life are dependent on. Long-term stress has been shown to disrupt the balance of the hypothalamic–pituitary–adrenal (HPA) axis. Adaptogens, such as Withania somnifera (ashwagandha), are commonly used in Ayurvedic medicine for stress relief and ameliorating HPA-axis dysfunction. The aim of this study was to support the role of a root and leaf water-extracted ashwagandha extract (WS) in stress reduction by confirming the lowest clinically validated dose for stress management (125 mg/day) in a dose-dependent clinical study in adults with self-reported high stress. Methods: An 8-week, randomized, double-blinded, placebo-controlled study to compare the effects of three different WS extract doses (125, 250 and 500 mg) was performed. A total of 131 adults were enrolled, and 98 were included in the final analysis. Attenuation of chronic stress was measured using the 14-item Perceived Stress Scale (PSS) and biochemical-related stress parameters. Results: We have shown that aqueous WS extract (roots and leaves) safely reduces mild to moderate chronic stress at doses of 125 mg, 250 mg, and 500 mg/day for 8 weeks. Conclusions: Our findings demonstrate the stress-reduction capabilities of this well-characterized aqueous extract of WS (root and leaf) at the low dose of 125 mg/day, in a dose-dependent manner, via the modulation of the HPA axis. Trial registration: This study was registered with the Clinical Trials Registry—India (CTRI) with the registration number: CTRI/2019/11/022100. Full article
Show Figures

Figure 1

10 pages, 1137 KiB  
Article
Clinical Factors Affecting the Rate of Liver Regeneration in Living Donors after Right Hepatectomy
by Minkyoung Kim, Suk-Won Suh, Eun Sun Lee, Sanggyun Suh, Seung Eun Lee and Yoo Shin Choi
J. Pers. Med. 2024, 14(5), 458; https://doi.org/10.3390/jpm14050458 (registering DOI) - 26 Apr 2024
Abstract
Sufficient liver regeneration after a right hepatectomy is important in living donors for preventing postoperative hepatic insufficiency; however, it differs for each living donor so we investigated the clinical factors affecting the rate of liver regeneration after hepatic resection. This retrospective case–control study [...] Read more.
Sufficient liver regeneration after a right hepatectomy is important in living donors for preventing postoperative hepatic insufficiency; however, it differs for each living donor so we investigated the clinical factors affecting the rate of liver regeneration after hepatic resection. This retrospective case–control study investigated fifty-four living donors who underwent a right hepatectomy from July 2015 to March 2023. Patients were classified into 2 groups by the remnant/total volume ratio (RTVR): Group A (RTVR < 30%, n = 9) and Group B (RTVR ≥ 30%, n = 45). The peak postoperative level of total bilirubin was more elevated in Group A than in Group B (3.0 ± 1.1 mg/dL vs. 2.3 ± 0.8 mg/dL, p = 0.046); however, no patients had hepatic insufficiency or major complications. The rates of residual liver volume (RLV) growth at Postoperative Week 1 (89.1 ± 26.2% vs. 53.5 ± 23.7%, p < 0.001) were significantly greater in Group A, and its significant predictors were RTVR (β = −0.478, p < 0.001, variance inflation factor (VIF) = 1.188) and intraoperative blood loss (β = 0.247, p = 0.038, VIF = 1.182). In conclusion, as the RLV decreases, compensatory liver regeneration after hepatic resection becomes more prominent, resulting in comparable operative outcomes. Further studies are required to investigate the relationship between hematopoiesis and the rate of liver regeneration. Full article
(This article belongs to the Special Issue Personalized Medicine in Organ Transplantation 2nd Edition)
Show Figures

Figure 1

14 pages, 5036 KiB  
Article
The Comminution of Chert Gravel by Microwave Irradiation
by Mark Tzibulsky and Vladimir Frid
Resources 2024, 13(5), 63; https://doi.org/10.3390/resources13050063 (registering DOI) - 26 Apr 2024
Abstract
Chert, a by-product rock of sand quarrying, has historically posed economic challenges for aggregate production, resulting in significant “waste” accumulation in quarries. Our study investigates the effect of microwave irradiation on the mechanical properties of chert gravel, a mineralogically homogenous material composed of [...] Read more.
Chert, a by-product rock of sand quarrying, has historically posed economic challenges for aggregate production, resulting in significant “waste” accumulation in quarries. Our study investigates the effect of microwave irradiation on the mechanical properties of chert gravel, a mineralogically homogenous material composed of fine quartz grains. The results, which demonstrate that increased irradiation time leads to a substantial decrease in chert gravel strength (by a factor of 4–6 for 2.5 min of irradiation), underscore the potential impact of this research on comminution processes. With quenching altering the fractional content of the samples after the crushing test, reducing the Gravel-to-Sand ratio, this study is driven by the promising potential of crushed chert gravel as a pivotal aggregate within the concrete and asphalt industries, offering a practical solution to their material needs. The urgent need to rehabilitate previously utilized quarry areas, offering an environmentally beneficial solution for which we all should be responsible, motivated the present study. Full article
Show Figures

Figure 1

17 pages, 1351 KiB  
Article
Palladium-Catalyzed Esterification of Aryl Fluorosulfates with Aryl Formates
by Xue Chen, Yuan Liang, Wen-Wen Wang, Chengping Miao, Xue-Qiang Chu, Weidong Rao, Hao Xu, Xiaocong Zhou and Zhi-Liang Shen
Molecules 2024, 29(9), 1991; https://doi.org/10.3390/molecules29091991 (registering DOI) - 26 Apr 2024
Abstract
An efficient palladium-catalyzed carbonylation of aryl fluorosulfates with aryl formates for the facile synthesis of esters was developed. The cross-coupling reactions proceeded effectively in the presence of a palladium catalyst, phosphine ligand, and triethylamine in DMF to produce the corresponding esters in moderate [...] Read more.
An efficient palladium-catalyzed carbonylation of aryl fluorosulfates with aryl formates for the facile synthesis of esters was developed. The cross-coupling reactions proceeded effectively in the presence of a palladium catalyst, phosphine ligand, and triethylamine in DMF to produce the corresponding esters in moderate to good yields. Of note, functionalities or substituents, such as nitro, cyano, methoxycarbonyl, trifluoromethyl, methylsulfonyl, trifluoromethoxy, fluoro, chloro, bromo, methyl, methoxy, N,N-dimethyl, and [1,3]dioxolyl, were well-tolerated in the reactions, which could be kept for late-stage modification. The reactions employing readily available and relatively robust aryl fluorosulfates as coupling electrophiles could potentially serve as an attractive alternative to traditional cross-couplings with the use of aryl halides and pseudohalides as substrates. Full article
(This article belongs to the Section Organic Chemistry)
Show Figures

Graphical abstract

19 pages, 5330 KiB  
Article
Dual Deletion of Keap1 and Rbpjκ Genes in Liver Leads to Hepatomegaly and Hypercholesterolemia
by Nobunao Wakabayashi, Yoko Yagishita, Tanvi Joshi and Thomas W. Kensler
Int. J. Mol. Sci. 2024, 25(9), 4712; https://doi.org/10.3390/ijms25094712 (registering DOI) - 26 Apr 2024
Abstract
The hepatic deletion of Rbpjκ (RbpjF/F::AlbCre) in the mouse leads to exhibition of the Alagille syndrome phenotype during early postnatal liver development with hyperlipidemia and cholestasis due to attenuated disruption of NOTCH signaling. Given the roles of NRF2 signaling [...] Read more.
The hepatic deletion of Rbpjκ (RbpjF/F::AlbCre) in the mouse leads to exhibition of the Alagille syndrome phenotype during early postnatal liver development with hyperlipidemia and cholestasis due to attenuated disruption of NOTCH signaling. Given the roles of NRF2 signaling in the regulation of lipid metabolism and bile ductal formation, it was anticipated that these symptoms could be alleviated by enhancing NRF2 signaling in the RbpjF/F::AlbCre mouse by hepatic deletion of Keap1 in compound Keap1F/F::RbpjF/F::AlbCre mice. Unexpectedly, these mice developed higher hepatic and plasma cholesterol levels with more severe cholestatic liver damage during the pre-weaning period than in the RbpjF/F::AlbCre mice. In addition, hypercholesterolemia and hepatic damage were sustained throughout the growth period unlike in the RbpjF/F::AlbCre mouse. These enhanced abnormalities in lipid metabolism appear to be due to NRF2-dependent changes in gene expression related to cholesterol synthetic and subsequent bile acid production pathways. Notably, the hepatic expression of Cyp1A7 and Abcb11 genes involved in bile acid homeostasis was significantly reduced in Keap1F/F::RbpjF/F::AlbCre compared to RbpjF/F::AlbCre mice. The accumulation of liver cholesterol and the weakened capacity for bile excretion during the 3 pre-weaning weeks in the Keap1F/F::RbpjF/F::AlbCre mice may aggravate hepatocellular damage level caused by both excessive cholesterol and residual bile acid toxicity in hepatocytes. These results indicate that a tuned balance of NOTCH and NRF2 signaling is of biological importance for early liver development after birth. Full article
(This article belongs to the Special Issue The Role of NRF2 in Health and Disease)
Show Figures

Figure 1

18 pages, 5573 KiB  
Article
Effects of Illumination Conditions on Individual Tree Height Extraction Using UAV LiDAR: Pilot Study of a Planted Coniferous Stand
by Tianxi Li, Jiayuan Lin, Wenjian Wu and Rui Jiang
Forests 2024, 15(5), 758; https://doi.org/10.3390/f15050758 (registering DOI) - 26 Apr 2024
Abstract
Tree height is one of the key dendrometric parameters for indirectly estimating the timber volume or aboveground biomass of a forest. Field measurement is time-consuming and labor-intensive, while unmanned aerial vehicle (UAV)-borne LiDAR is a more efficient tool for acquiring tree heights of [...] Read more.
Tree height is one of the key dendrometric parameters for indirectly estimating the timber volume or aboveground biomass of a forest. Field measurement is time-consuming and labor-intensive, while unmanned aerial vehicle (UAV)-borne LiDAR is a more efficient tool for acquiring tree heights of large-area forests. Although individual tree heights extracted from point cloud data are of high accuracy, they are still affected by some weather and environment factors. In this study, taking a planted M. glyptostroboides (Metasequoia glyptostroboides Hu & W.C. Cheng) stand as the study object, we preliminarily assessed the effects of various illumination conditions (solar altitude angle and cloud cover) on tree height extraction using UAV LiDAR. The eight point clouds of the target stand were scanned at four time points (sunrise, noon, sunset, and night) in two consecutive days (sunny and overcast), respectively. The point clouds were first classified into ground points and aboveground vegetation points, which accordingly produced digital elevation model (DEM) and digital surface model (DSM). Then, the canopy height model (CHM) was obtained by subtracting DEM from DSM. Subsequently, individual trees were segmented based on the seed points identified by local maxima filtering. Finally, the individual tree heights of sample trees were separately extracted and assessed against the in situ measured values. As results, the R2 and RMSEs of tree heights obtained in the overcast daytime were commonly better than those in the sunny daytime; the R2 and RMSEs at night were superior among all time points, while those at noon were poorest. These indicated that the accuracy of individual tree height extraction had an inverse correlation with the intensity of illumination. To obtain more accurate tree heights for forestry applications, it is best to acquire point cloud data using UAV LiDAR at night, or at least not at noon when the illumination is generally strongest. Full article
(This article belongs to the Topic Individual Tree Detection (ITD) and Its Applications)
Show Figures

Figure 1

16 pages, 2119 KiB  
Article
The Effect of High-Pressure Processing of Caprine Milk on the Production and Properties of Yoghurt
by Agnieszka Jankowska, Katarzyna Kiełczewska, Maria Wachowska, Aneta Dąbrowska, Krzysztof Siemianowski, Elżbieta Haponiuk and Katarzyna Stasiewicz
Foods 2024, 13(9), 1327; https://doi.org/10.3390/foods13091327 (registering DOI) - 26 Apr 2024
Abstract
The aim of this study was to determine the suitability of HP-treated caprine milk for yoghurt production and to evaluate the effect of HP treatment on yoghurt properties. Reconstituted caprine milk was subjected to HP treatment (350 MPa/10 min/20 °C); a lactic acid [...] Read more.
The aim of this study was to determine the suitability of HP-treated caprine milk for yoghurt production and to evaluate the effect of HP treatment on yoghurt properties. Reconstituted caprine milk was subjected to HP treatment (350 MPa/10 min/20 °C); a lactic acid starter culture (YC-X16, Chr. Hansen) was added. Milk was fermented at a temperature of 43 °C until pH 4.60. Bacterial counts, pH, color, rheological characteristics, texture, microstructure, and the sensory attributes of the yoghurt were determined after production and after seven days of storage at a temperature of 4 °C. HP treatment increased color saturation and whiteness index and induced a minor increase in milk pH. Minor differences in the acidification curve were noted. During storage, Streptococcus thermophilus counts were significantly higher in yoghurt from HP-treated than from untreated milk, whereas Lactobacillus delbruecki ssp. bulgaricus counts remained stable. A color analysis did not reveal differences between the experimental and control yoghurts. After storage, yoghurt made from HP-treated milk was characterized by thicker consistency and lower rheological stability than the control yoghurt. The micrographs of the yoghurts confirmed the differences in rheological parameters. Yoghurt produced from HP-treated caprine milk and stored for seven days received the highest scores in the sensory evaluation. Full article
(This article belongs to the Section Dairy)
Show Figures

Figure 1

11 pages, 590 KiB  
Article
Platelet-Rich Plasma Injections in Chronic Lateral Ankle Instability: A Case Series
by Ivan Medina-Porqueres, Pablo Martin-Garcia, Sofia Sanz-De-Diego, Marcelo Reyes-Eldblom, Francisco Moya-Torrecilla, Rafael Mondragon-Cortes, Daniel Rosado-Velazquez and Abel Gomez-Caceres
Biomedicines 2024, 12(5), 963; https://doi.org/10.3390/biomedicines12050963 (registering DOI) - 26 Apr 2024
Abstract
The platelet-rich plasma (PRP) approach may be an effective treatment for joint and cartilage pathologies. However, the rationale for its effectiveness on joint instability is limited. This study aimed to assess the safety and effectiveness of PRP injections in patients with chronic lateral [...] Read more.
The platelet-rich plasma (PRP) approach may be an effective treatment for joint and cartilage pathologies. However, the rationale for its effectiveness on joint instability is limited. This study aimed to assess the safety and effectiveness of PRP injections in patients with chronic lateral ankle instability (CLAI). This retrospective study was performed at a single-center outpatient clinic between January 2015 and February 2023 and included pre-intervention assessment and short-term follow-up. Patients were excluded if they had received previous surgical treatment or had constitutional hyperlaxity, systemic diseases, or grade II or III osteoarthritis. The clinical and functional evaluation consisted of the Karlsson score, the Cumberland Ankle Instability Tool (CAIT), Good’s grading system, the patient’s subjective satisfaction level, and the time required to return to exercise. The entire PRP therapy regime consisted of three PRP administrations at 7-day intervals and follow-up appointments. PRP was administered both intraarticularly and into talofibular ligaments. A total of 47 consecutive patients with CLAI were included, 11 were female (23.4%), with a mean age at intervention of 31.19 ± 9.74 years. A statistically significant improvement was found in the CAIT and Karlsson scores at 3 months (27.74 ± 1.68 and 96.45 ± 4.28, respectively) relative to the pre-intervention status (10.26 ± 4.33 and 42.26 ± 14.9, respectively, p < 0.000). The mean follow-up of patients with CLAI was 17.94 ± 3.25 weeks. This study represents successful short-term functional and clinical outcomes in patients with CLAI after PRP treatment, with no adverse effects. It demonstrates the feasibility of a randomized controlled trial to further assess this therapy. Full article
(This article belongs to the Special Issue Musculoskeletal Regenerative Medicine)
Show Figures

Figure 1

22 pages, 4413 KiB  
Article
Thermal Stability, Durability, and Service Life Estimation of Woven Flax-Carbon Hybrid Polyamide Biocomposites
by Mohsen Bahrami, Juana Abenojar, Gladis M. Aparicio and Miguel Angel Martínez
Materials 2024, 17(9), 2020; https://doi.org/10.3390/ma17092020 (registering DOI) - 26 Apr 2024
Abstract
Woven flax-carbon hybrid polyamide biocomposites offer a blend of carbon fibers’ mechanical strength and flax’s environmental advantages, potentially developing material applications. This study investigated their thermal behavior, degradation kinetics, and durability to water uptake and relative humidity exposure and compared them with pure [...] Read more.
Woven flax-carbon hybrid polyamide biocomposites offer a blend of carbon fibers’ mechanical strength and flax’s environmental advantages, potentially developing material applications. This study investigated their thermal behavior, degradation kinetics, and durability to water uptake and relative humidity exposure and compared them with pure flax and carbon composites with the same matrix. The hybrid composite exhibited intermediate water/moisture absorption levels between pure flax and carbon composites, with 7.2% water absorption and 3.5% moisture absorption. It also displayed comparable thermal degradation resistance to the carbon composite, effectively maintaining its weight up to 300 °C. Further analysis revealed that the hybrid composite exhibited a decomposition energy of 268 kJ/mol, slightly lower than the carbon composite’s value of 288.5 kJ/mol, indicating similar thermal stability. Isothermal lifetime estimation, employing the activation energy (Ed) and degree of conversion facilitated by the Model Free Kinetics method, indicated a 41% higher service life of the hybrid laminate at room temperature compared to the carbon laminate. These insights are crucial for understanding the industrial applications of these materials without compromising durability. Full article
Show Figures

Figure 1

23 pages, 6742 KiB  
Article
A Cost-Effective Integrated Methodology for Electromagnetic Actuation via Visual Feedback
by Shuwan Chen, Damiano Padovani, Andrea Cioncolini and Angelo Alessandri
Sensors 2024, 24(9), 2760; https://doi.org/10.3390/s24092760 (registering DOI) - 26 Apr 2024
Abstract
Electromagnetic actuation can support many fields of technology, such as robotics or biomedical applications. In this context, fully understanding the system behavior and proposing a low-cost package for feedback control is challenging. Modeling the electromagnetic force is particularly tricky because it is a [...] Read more.
Electromagnetic actuation can support many fields of technology, such as robotics or biomedical applications. In this context, fully understanding the system behavior and proposing a low-cost package for feedback control is challenging. Modeling the electromagnetic force is particularly tricky because it is a nonlinear function of the actuated object’s position and coil’s current. Measuring in real time the position of the actuated object with the precision required for accurate motion control is also nontrivial. In this study, we propose a novel, cost-effective electromagnetic set-up to achieve position control via visual feedback. We actuated vertically and under different experimental conditions a 10 mm diameter steel ball hanging on a low-stiffness spring, demonstrating good tracking performance (the position error remained within ±0.5 mm, with a negligible phase delay in the best scenarios). The experimental results confirm the feasibility of the proposed set-up, which is characterized by minimum complexity and realized with off-the-shelf and cost-effective components. For these reasons, such a contribution helps to understand and apply electromagnetic actuation even further. Full article
(This article belongs to the Section Navigation and Positioning)
Show Figures

Figure 1

17 pages, 3669 KiB  
Article
DBO-CNN-BiLSTM: Dung Beetle Optimization Algorithm-Based Thrust Estimation for Micro-Aero Engine
by Baijun Lei, Haozhong Huang, Guixin Chen, Jianguo Liang and Huigui Long
Aerospace 2024, 11(5), 344; https://doi.org/10.3390/aerospace11050344 (registering DOI) - 26 Apr 2024
Abstract
Thrust constitutes a pivotal performance parameter for aircraft engines. Thrust, being an indispensable parameter in control systems, has garnered significant attention, prompting numerous scholars to propose various methods and algorithms for its estimation. However, research methods for estimating the thrust of the micro-turbojet [...] Read more.
Thrust constitutes a pivotal performance parameter for aircraft engines. Thrust, being an indispensable parameter in control systems, has garnered significant attention, prompting numerous scholars to propose various methods and algorithms for its estimation. However, research methods for estimating the thrust of the micro-turbojet engines used in unmanned aerial vehicles are relatively scarce. Therefore, this paper proposes a thrust estimator for micro-turbojet engines based on DBO (dung beetle optimization) utilizing bidirectional long short-term memory (BiLSTM) and a convolutional neural network (CNN). Furthermore, the efficacy of the proposed model is further validated through comparative analysis with others in this paper. Full article
Show Figures

Figure 1

18 pages, 1533 KiB  
Systematic Review
Closing the Gap: The Tripartite Structure of Sustainability as a Tool for Sustainable Education—A Systematic Literature Review
by Barbara E. Meyer, Elena Gaertner and Christian Elting
Sustainability 2024, 16(9), 3622; https://doi.org/10.3390/su16093622 (registering DOI) - 26 Apr 2024
Abstract
(1) In an era where sustainable behavior is increasingly crucial, understanding the discrepancy between individuals’ sustainability-oriented values and their actual behaviors, known as the inner–outer gap, is vital. This systematic literature review explores the potential of the Tripartite Structure of Sustainability (TSS) framework [...] Read more.
(1) In an era where sustainable behavior is increasingly crucial, understanding the discrepancy between individuals’ sustainability-oriented values and their actual behaviors, known as the inner–outer gap, is vital. This systematic literature review explores the potential of the Tripartite Structure of Sustainability (TSS) framework to address this gap within the context of sustainable education. By reviewing the literature from the APA, ERIC, and Web of Science databases, searched on 25 October 2020, the factors influencing sustainable actions were systematically examined. Articles had to be relevant to the topic (sustainability, morality in relation to sustainability, or morality in general) and report on empirically validated factors that have an impact on the inner-outer gap. (2) By employing a qualitative content analysis approach, 56 articles over a 15-year period were analyzed, identifying 83 factors that either bridged or reinforced the inner–outer gap. These factors were categorized within the TSS framework, which segments sustainability-oriented actions into individual, social, and self-transcendent domains, alongside their activation points: stable, situational, or automated. (3) The analysis revealed that self-focused factors often reinforce the gap, suggesting they are a hindrance to sustainable behavior. Conversely, self-transcendent factors consistently bridged the gap, promoting sustainability. Social factors showed variable impacts based on the ethical and sustainable context they were placed in, suggesting that the social environment’s orientation significantly influences sustainable behavior. (4) This study concludes that the TSS framework offers a promising approach to advancing education for sustainable development (ESD) and contributes insights into how to promote the required paradigm shift towards holistic and interconnected perspectives. Full article
(This article belongs to the Section Sustainable Education and Approaches)
Show Figures

Figure 1

21 pages, 13150 KiB  
Article
A Comprehensive Resource Assessment for Wind Power Generation on the Rural Island of Sibuyan, Philippines
by Jerome G. Gacu, Junrey D. Garcia, Eddie G. Fetalvero, Merian P. Catajay-Mani, Cris Edward F. Monjardin and Christopher Power
Energies 2024, 17(9), 2055; https://doi.org/10.3390/en17092055 (registering DOI) - 26 Apr 2024
Abstract
Amid rising energy demands in rural areas, thorough resource assessments for initiatives such as wind power are crucial. This study involves a land resource assessment for wind power generation on the rustic Sibuyan Island in the Philippines, which is currently experiencing an electricity [...] Read more.
Amid rising energy demands in rural areas, thorough resource assessments for initiatives such as wind power are crucial. This study involves a land resource assessment for wind power generation on the rustic Sibuyan Island in the Philippines, which is currently experiencing an electricity shortage. A comprehensive overview of the island’s suitability for wind energy projects is performed via evaluation and analysis using geospatial data and multi-criteria decision making (MCDM). The research results indicate that 50.44% (220.68 km2) of the island’s land area is categorized as ‘poorly suitable’ since it considers protected areas where developments are not allowed. Only 0.08% (0.35 km2) of the island can be classified as ‘marginally suitable’, while 9.15% (40.73 km2), 36.64% (176.39 km2), and 0.69% (3.05 km2) are labeled as ‘moderately suitable’, ‘suitable’, and ‘highly suitable’, respectively. This confirms the potential for wind energy exploration on the island. Delineating the suitability levels provides a foundational framework for stakeholders that enables them to identify optimal sites for wind power, sustain the island’s resources, and contribute to the renewable energy landscape of this rural location. Overall, this study, underpinned by data analysis, offers invaluable insights for decision making in wind power development, with the presented framework adaptable to other areas of interest. Full article
(This article belongs to the Special Issue Wind Turbines, Wind Farms, and Wind Energy: 2nd Edition)
Show Figures

Figure 1

14 pages, 530 KiB  
Article
Expression of Selected miRNAs in Undifferentiated Carcinoma with Osteoclast-like Giant Cells (UCOGC) of the Pancreas: Comparison with Poorly Differentiated Pancreatic Ductal Adenocarcinoma
by Alexey Popov, Jan Hrudka, Arpád Szabó, Martin Oliverius, Zdeněk Šubrt, Jana Vránová, Vanda Ciprová, Jana Moravcová and Václav Mandys
Biomedicines 2024, 12(5), 962; https://doi.org/10.3390/biomedicines12050962 (registering DOI) - 26 Apr 2024
Abstract
Undifferentiated carcinoma with osteoclast-like giant cells (UCOGC) of the pancreas represents a rare subtype of pancreatic ductal adenocarcinoma (PDAC). Despite a distinct morphology and specific clinical behavior, UCOGCs exhibit unexpected similarities in regard to DNA mutational profiles with conventional PDAC. Treating pancreatic ductal [...] Read more.
Undifferentiated carcinoma with osteoclast-like giant cells (UCOGC) of the pancreas represents a rare subtype of pancreatic ductal adenocarcinoma (PDAC). Despite a distinct morphology and specific clinical behavior, UCOGCs exhibit unexpected similarities in regard to DNA mutational profiles with conventional PDAC. Treating pancreatic ductal adenocarcinoma is particularly challenging, with limited prospects for cure. As with many other malignant neoplasms, the exploration of microRNAs (miRNAs, miRs) in regulating the biological characteristics of pancreatic cancer is undergoing extensive investigation to enhance tumor diagnostics and unveil the therapeutic possibilities. Herein, we evaluated the expression of miR-21, -96, -148a, -155, -196a, -210, and -217 in UCOGCs and poorly differentiated (grade 3, G3) PDACs. The expression of miR-21, miR-155, and miR-210 in both UCOGCs and G3 PDACs was significantly upregulated compared to the levels in normal tissue, while the levels of miR-148a and miR-217 were downregulated. We did not find any significant differences between cancerous and normal tissues for the expression of miR-96 and miR-196a in G3 PDACs, whereas miR-196a was slightly, but significantly, downregulated in UCOGCs. On the other hand, we have not observed significant differences in the expression of the majority of miRNAs between UCOGC and G3 PDAC, with the exception of miR-155. UCOGC samples demonstrated lower mean levels of miR-155 in comparison with those in G3 PDACs. Full article
Show Figures

Figure 1

25 pages, 2348 KiB  
Article
Resource Scheduling Optimization of Fresh Food Delivery Porters Considering Ambient Temperature Variations
by Ziyu Shan and Jianming Yao
Sustainability 2024, 16(9), 3624; https://doi.org/10.3390/su16093624 (registering DOI) - 26 Apr 2024
Abstract
In the context of an evolving socio-economic landscape and rising living standards, the online market for fresh products, encompassing fruits, vegetables, meats, dairy, and eggs, has seen substantial growth, necessitating sophisticated logistics for e-commerce home delivery. This study tackles the distinct challenges of [...] Read more.
In the context of an evolving socio-economic landscape and rising living standards, the online market for fresh products, encompassing fruits, vegetables, meats, dairy, and eggs, has seen substantial growth, necessitating sophisticated logistics for e-commerce home delivery. This study tackles the distinct challenges of fresh product delivery, which demand rigorous adherence to climate conditions and product mix during transport, significantly influencing the operational strategies and scheduling of delivery platforms. To address these challenges, a comprehensive mathematical model was developed to optimize fresh food home delivery scheduling, focusing on reducing spoilage rates and accommodating the dynamic impact of environmental temperature changes. The model posits assumptions of a consistent and ample supply of fresh goods, standard initial quality loss, and efficient porter assignment for multi-category order combinations. It introduces three objective functions, targeting the minimization of fresh food loss, maximization of customer satisfaction, and reduction of distributor costs. The efficacy of the model and its genetic-algorithm-based solution method was assessed through numerical analysis and case studies, illustrating that the model enhances delivery efficiency and service quality across varying temperature conditions. This substantiates the critical role of environmental temperature management in optimizing fresh food delivery, offering a robust framework for advancing logistical operations in the perishable goods sector and ensuring quality and efficiency in fresh food e-commerce delivery. Full article
(This article belongs to the Section Energy Sustainability)
Show Figures

Figure 1

11 pages, 1831 KiB  
Article
Multi-Magnet Cochlear-Implant Technology and Magnetic Resonance Imaging: The Safety Issue
by Pietro Canzi, Elena Carlotto, Elisabetta Zanoletti, Johan H. M. Frijns, Daniele Borsetto, Antonio Caruso, Luisa Chiapparini, Andrea Ciorba, Giorgio Conte, Nathan Creber, Stefania Criscuolo, Filippo Di Lella, Sebastiano Franchella, Erik F. Hensen, Lorenzo Lauda, Stefano Malpede, Marco Mandalà, Liselotte J. C. Rotteveel, Anna Simoncelli, Anna Chiara Stellato, Diego Zanetti and Marco Benazzoadd Show full author list remove Hide full author list
Audiol. Res. 2024, 14(3), 401-411; https://doi.org/10.3390/audiolres14030034 (registering DOI) - 26 Apr 2024
Abstract
Despite the spread of novel-generation cochlear-implant (CI) magnetic systems, access to magnetic resonance imaging (MRI) for CI recipients is still limited due to safety concerns. The aim of this study is to assess and record the experiences of Hires Ultra 3D (Advanced Bionics) [...] Read more.
Despite the spread of novel-generation cochlear-implant (CI) magnetic systems, access to magnetic resonance imaging (MRI) for CI recipients is still limited due to safety concerns. The aim of this study is to assess and record the experiences of Hires Ultra 3D (Advanced Bionics) recipients who underwent an MRI examination. A multicentric European survey about this topic was conducted focusing on safety issues, and the results were compared with the current literature. We collected a total of 65 MRI scans performed in 9 otologic referral centers for a total of 47 Hires Ultra 3D recipients, including, for the first time, 2 children and 3 teenagers. Preventive measures were represented by scanning time and sedation for children. Head wrapping was used in eight cases, and six of the eight cases received local anesthesia, even if both measures were not needed. Only three patients complained of pain (3/65 examinations, 4.6%) due to the tight head bandage, and one of the three cases required MRI scan interruption. No other adverse events were reported. We believe that these results should encourage MRI execution in accordance with manufacturer recommendations for Ultra 3D recipients. Full article
Show Figures

Figure 1

18 pages, 10223 KiB  
Article
Chitosan Oligosaccharides Mitigate Flooding Stress Damage in Rice by Affecting Antioxidants, Osmoregulation, and Hormones
by Haoyu Lu, Mei Wang, Shangfeng Zhou, Ke Chen, Lifeng Wang, Zhenxie Yi, Lianyang Bai and Yuzhu Zhang
Antioxidants 2024, 13(5), 521; https://doi.org/10.3390/antiox13050521 (registering DOI) - 26 Apr 2024
Abstract
Rice (Oryza sativa L.) is one of the most important food crops worldwide. However, during direct seeding, rice is extremely vulnerable to flooding stress, which impairs rice’s emergence and seedling growth and results in a significant yield loss. According to our research, [...] Read more.
Rice (Oryza sativa L.) is one of the most important food crops worldwide. However, during direct seeding, rice is extremely vulnerable to flooding stress, which impairs rice’s emergence and seedling growth and results in a significant yield loss. According to our research, chitosan oligosaccharides have the potential to be a chemical seed-soaking agent that greatly increases rice’s resistance to flooding. Chitosan oligosaccharides were able to enhance seed energy supply, osmoregulation, and antioxidant capacity, according to physiological index assessments. Using transcriptome and metabolomic analysis, we discovered that important differential metabolites and genes were involved in the signaling pathway for hormone synthesis and antioxidant capacity. Exogenous chitosan oligosaccharides specifically and significantly inhibit genes linked to auxin, jasmonic acid, and abscisic acid. This suggested that applying chitosan oligosaccharides could stabilize seedling growth and development by controlling associated hormones and reducing flooding stress by enhancing membrane stability and antioxidant capacity. Finally, we verified the effectiveness of exogenous chitosan oligosaccharides imbibed in seeds by field validation, demonstrating that they can enhance rice seedling emergence and growth under flooding stress. Full article
(This article belongs to the Special Issue Antioxidant Mechanisms and Redox Signalling in Seeds)
Show Figures

Figure 1

14 pages, 1469 KiB  
Article
Distribution Characteristics of Low-Molecular-Weight Organic Acids in Reclaimed Soil Filled with Fly Ash: A Study
by Yonghong Zheng, Yue Wu, Zhiguo Zhang, Fangling Chen, Qingbin Ma, Zihao Kong and Ying Ma
Toxics 2024, 12(5), 312; https://doi.org/10.3390/toxics12050312 (registering DOI) - 26 Apr 2024
Abstract
This study aims to assess the contents of different kinds of low-molecular-weight organic acids (LMWOAs) in reclaimed soil filled with fly ash in the Huainan mining area in China using high-performance liquid chromatography (HPLC). Using a mobile phase consisting of 0.1% phosphoric acid [...] Read more.
This study aims to assess the contents of different kinds of low-molecular-weight organic acids (LMWOAs) in reclaimed soil filled with fly ash in the Huainan mining area in China using high-performance liquid chromatography (HPLC). Using a mobile phase consisting of 0.1% phosphoric acid and acetonitrile in a volume ratio of 98:2, the detection was performed at a wavelength of 210 nm for 15 min. In addition, a cluster analysis was performed on the detected LMWOAs in the reclaimed soil. The correlations between the LMWOA and nutrient contents in the reclaimed soil were also analyzed. In total, eight and seven LMWOAs were detected in the reclaimed soil and filled fly ash, respectively. In contrast, no LMWOAs were detected in the fresh fly ash from a thermal power plant. The order of total LMWOA contents at different sampling points followed the order of farmland control soil > 1# (Triticum aestivum) > 4# (Phragmites australis) > 5# (Vigna radiata) > 2# (Sorghum bicolor) > 3# (Tamarix ramosissima) > fly ash-filled soil. The farmland control soil and fly ash-filled soil exhibited the highest and lowest LMWOA contents of 648.22 and 85.09 μg·g−1, respectively. The LMWOA contents in the reclaimed soil followed the order of oxalic acid > tartaric acid > malonic acid > lactic acid > acetic acid > citric acid > propionic acid > succinic acid. Indeed, oxalic acids exhibited the highest total amount of 1445.79 μg·g−1 and succinic acids exhibited the lowest total amount of 6.50 μg·g−1. The LMWOA contents in the reclaimed soil decreased with increasing soil depth, showing statistically significant differences between the 0–10 and 10–40 cm soil layers (p < 0.05). According to the obtained clustering results, the detected LMWOAs can be divided into two categories. The first category consisted of oxalic acid, while the second category included the remaining LMWOAs. The soil LMWOA contents of 4# (Phragmites australis) and 5# (Vigna radiata) were significantly different from those at the other sampling points. According to the Pearson correlation analysis results, the occurrence and characteristics of the soil LMWOAs can be controlled by regulating the pH values and available nutrient contents in the soil, thereby improving the eco-environmental conditions of the reclaimed rhizosphere. Full article
Show Figures

Figure 1

16 pages, 4673 KiB  
Article
Highly Self-Adaptive Path-Planning Method for Unmanned Ground Vehicle Based on Transformer Encoder Feature Extraction and Incremental Reinforcement Learning
by Tao Zhang, Jie Fan, Nana Zhou and Zepeng Gao
Machines 2024, 12(5), 289; https://doi.org/10.3390/machines12050289 (registering DOI) - 26 Apr 2024
Abstract
Path planning is an indispensable component in guiding unmanned ground vehicles (UGVs) from their initial positions to designated destinations, aiming to determine trajectories that are either optimal or near-optimal. While conventional path-planning techniques have been employed for this purpose, planners utilizing reinforcement learning [...] Read more.
Path planning is an indispensable component in guiding unmanned ground vehicles (UGVs) from their initial positions to designated destinations, aiming to determine trajectories that are either optimal or near-optimal. While conventional path-planning techniques have been employed for this purpose, planners utilizing reinforcement learning (RL) exhibit superior adaptability within exceedingly complex and dynamic environments. Nevertheless, existing RL-based path planners encounter several shortcomings, notably, redundant map representations, inadequate feature extraction, and limited adaptiveness across diverse environments. In response to these challenges, this paper proposes an innovative and highly self-adaptive path-planning approach based on Transformer encoder feature extraction coupled with incremental reinforcement learning (IRL). Initially, an autoencoder is utilized to compress redundant map representations, providing the planner with sufficient environmental data while minimizing dimensional complexity. Subsequently, the Transformer encoder, renowned for its capacity to analyze global long-range dependencies, is employed to capture intricate correlations among UGV statuses at continuous intervals. Finally, IRL is harnessed to enhance the path planner’s generalization capabilities, particularly when the trained agent is deployed in environments distinct from its training counterparts. Our empirical findings demonstrate that the proposed method outperforms traditional uniform-sampling-based approaches in terms of execution time, path length, and trajectory smoothness. Furthermore, it exhibits a fivefold increase in adaptivity compared to conventional transfer-learning-based fine-tuning methodologies. Full article
Show Figures

Figure 1

17 pages, 832 KiB  
Review
Mapping and Omics Integration: Towards Precise Rice Disease Resistance Breeding
by John Christian Ontoy and Jong Hyun Ham
Plants 2024, 13(9), 1205; https://doi.org/10.3390/plants13091205 (registering DOI) - 26 Apr 2024
Abstract
Rice (Oryza sativa), as a staple crop feeding a significant portion of the global population, particularly in Asian countries, faces constant threats from various diseases jeopardizing global food security. A precise understanding of disease resistance mechanisms is crucial for developing resilient [...] Read more.
Rice (Oryza sativa), as a staple crop feeding a significant portion of the global population, particularly in Asian countries, faces constant threats from various diseases jeopardizing global food security. A precise understanding of disease resistance mechanisms is crucial for developing resilient rice varieties. Traditional genetic mapping methods, such as QTL mapping, provide valuable insights into the genetic basis of diseases. However, the complex nature of rice diseases demands a holistic approach to gain an accurate knowledge of it. Omics technologies, including genomics, transcriptomics, proteomics, and metabolomics, enable a comprehensive analysis of biological molecules, uncovering intricate molecular interactions within the rice plant. The integration of various mapping techniques using multi-omics data has revolutionized our understanding of rice disease resistance. By overlaying genetic maps with high-throughput omics datasets, researchers can pinpoint specific genes, proteins, or metabolites associated with disease resistance. This integration enhances the precision of disease-related biomarkers with a better understanding of their functional roles in disease resistance. The improvement of rice breeding for disease resistance through this integration represents a significant stride in agricultural science because a better understanding of the molecular intricacies and interactions underlying disease resistance architecture leads to a more precise and efficient development of resilient and productive rice varieties. In this review, we explore how the integration of mapping and omics data can result in a transformative impact on rice breeding for enhancing disease resistance. Full article
(This article belongs to the Collection Advances in Plant Breeding)
Show Figures

Figure 1

14 pages, 7544 KiB  
Article
Insight into the Hot Corrosion Behavior of FeMnCrSi/TiC Coatings at 900 °C
by Xu Tang, Lei Li, Ze Huang, Jieji Zhou, Yonghuang Qin, Shiyang Zhao, Da Liu, Zhengbing Xu, Jianmin Zeng, Hongqun Tang and Youbin Wang
Metals 2024, 14(5), 504; https://doi.org/10.3390/met14050504 (registering DOI) - 26 Apr 2024
Abstract
This study explores the deposition of an Fe-MnCrSi/TiC coating on 45 steel surfaces using high-velocity arc spraying technology, examining the microstructure and hot corrosion behavior of the resultant layer. The microstructure of the FeMnCrSi/TiC coating primarily consists of an α-Fe (BCC) solid solution, [...] Read more.
This study explores the deposition of an Fe-MnCrSi/TiC coating on 45 steel surfaces using high-velocity arc spraying technology, examining the microstructure and hot corrosion behavior of the resultant layer. The microstructure of the FeMnCrSi/TiC coating primarily consists of an α-Fe (BCC) solid solution, composed of Fe, Mn, Cr, Si, C, and other elements, with a minor presence of β-Fe (FCC) solid-solution phase and unmelted TiC particles. Following 100 h of cyclic 900 °C hot corrosion, Mn on the coating surface preferentially oxidizes, forming a manganese-rich oxide layer. This process reduces the oxygen partial pressure (O2) within the coating, prompting the formation of a dense Cr2O3 layer on the inner side of the oxide layer. Concurrently, the rapid diffusion of Mn and Cr elements triggers the generation of Mn- and Cr-deficient regions at the metal/oxide layer interface, inducing the transformation of the coated metal primary matrix from an FCC + BCC dual phase to an α-Fe (BCC) single phase. After the reaction, the hot corrosion weight gain of the coating reached 12.43 mg/cm2, approximately one-fourteenth of the weight gain of the 45 steel substrates. This weight gain adheres to the parabolic law, suggesting that the FeMnCrSi/TiC coating exhibits excellent corrosion resistance under the given conditions. Full article
Show Figures

Figure 1

12 pages, 3245 KiB  
Article
Transparent and Efficient Wood-Based Triboelectric Nanogenerators for Energy Harvesting and Self-Powered Sensing
by Ting Cheng, Kunli Cao, Yidan Jing, Hongyan Wang and Yan Wu
Polymers 2024, 16(9), 1208; https://doi.org/10.3390/polym16091208 (registering DOI) - 26 Apr 2024
Abstract
Wood possesses several advantageous qualities including innocuity, low cost, aesthetic appeal, and excellent biocompatibility, and its naturally abundant functional groups and diverse structural forms facilitate functionalization modification. As the most sustainable bio-based material, the combination of wood with triboelectric nanogenerators (TENGs) stands poised [...] Read more.
Wood possesses several advantageous qualities including innocuity, low cost, aesthetic appeal, and excellent biocompatibility, and its naturally abundant functional groups and diverse structural forms facilitate functionalization modification. As the most sustainable bio-based material, the combination of wood with triboelectric nanogenerators (TENGs) stands poised to significantly advance the cause of green sustainable production while mitigating the escalating challenges of energy consumption. However, the inherent weak polarizability of natural wood limits its development for TENGs. Herein, we present the pioneering development of a flexible transparent wood-based triboelectric nanogenerator (TW-TENG) combining excellent triboelectrical properties, optical properties, and wood aesthetics through sodium chlorite delignification and epoxy resin impregnation. Thanks to the strong electron-donating groups in the epoxy resin, the TW-TENG obtained an open-circuit voltage of up to ~127 V, marking a remarkable 530% enhancement compared to the original wood. Furthermore, durability and stability were substantiated through 10,000 working cycles. In addition, the introduction of epoxy resin and lignin removal endowed the TW-TENG with excellent optical characteristics, with optical transmittance of up to 88.8%, while preserving the unique texture and aesthetics of the wood completely. Finally, we show the application prospects of TW-TENGs in the fields of self-power supply, motion sensing, and smart home through the demonstration of a TW-TENG in the charging and discharging of capacitors and the output of electrical signals in different scenarios. Full article
(This article belongs to the Special Issue High Proformance Wood Coating)
Show Figures

Figure 1

12 pages, 6839 KiB  
Article
Recognition of a Single β-D-Xylopyranose Molecule by Xylanase GH11 from Thermoanaerobacterium saccharolyticum
by Ki Hyun Nam
Crystals 2024, 14(5), 402; https://doi.org/10.3390/cryst14050402 (registering DOI) - 26 Apr 2024
Abstract
The endo-β-1,4-xylanase glycosyl hydrolase (GH11) decomposes the backbone of xylan into xylooligosaccharides or xylose. These enzymes are important for industrial applications in the production of biofuel, feed, food, and value-added materials. β-D-xylopyranose (XYP, also known as β-D-xylose) is the fundamental unit of the [...] Read more.
The endo-β-1,4-xylanase glycosyl hydrolase (GH11) decomposes the backbone of xylan into xylooligosaccharides or xylose. These enzymes are important for industrial applications in the production of biofuel, feed, food, and value-added materials. β-D-xylopyranose (XYP, also known as β-D-xylose) is the fundamental unit of the substrate xylan, and understanding its recognition is fundamental for the initial steps of GH11’s molecular mechanism. However, little is known about the recognition of a single XYP molecule by GH11. In this study, the crystal structures of GH11 from Thermoanaerobacterium saccharolyticum (TsaGH11) complexed with an XYP molecule were determined at a resolution of 1.7–1.9 Å. The XYP molecule binds to subsite −2 of the substrate-binding cleft. The XYP molecule is mainly stabilized by a π–π interaction with the conserved Trp36 residue. The O2 and O3 atoms of XYP are stabilized by hydrogen bond interactions with the hydroxyl groups of Tyr96 and Tyr192. The conformation of the thumb domain of TsaGH11 does not play a critical role in XYP binding, and XYP binding induces a shift in the thumb domain of TsaGH11 toward the XYP molecule. A structural comparison of TsaGH11 with other GH11 xylanases revealed that the XYP molecule forms π–π stacking with the center between the phenyl and indoline ring of Trp36, whereas the XYP molecule unit from xylobiose or xylotetraose forms π–π stacking with the indoline of Trp36, which indicates that the binding modes of the substrate and XYP differ. These structural results provide a greater understanding of the recognition of XYP by the GH11 family. Full article
(This article belongs to the Special Issue The Crystal Structure and Characteristics of Enzymes)
Show Figures

Figure 1

Open Access Journals

Browse by Indexing Browse by Subject Selected Journals
Back to TopTop