This study’s goals are divided into two categories. The first is to design and build an excavator equipped with parallel electrical linear actuators. The second is to generate and test a PSO-based and a PFM-based path for this excavator in order to save energy by reducing energy consumption, improve the digging accuracy by minimizing the deviation between the desired and dug surfaces of the ground, and prevent colliding with subsurface objects. For this purpose, computer vision was employed to improve monitoring and verification. Five types of experiments were carried out in this investigation. The first two and the other three examined the impact of energy conservation in PSO- and PFM-based path generation, respectively. Finally, the results from these experiments were compared to identify and show the effect of optimal path generation. Full article

SARS-CoV-2 vaccination-induced protection against infection is likely to be affected by functional antibody features. To understand the kinetics of antibody responses in healthy individuals after primary series and third vaccine doses, sera from the recipients of the two licensed SARS-CoV-2 mRNA vaccines were assessed for circulating anti-SARS-CoV-2 spike IgG levels and avidity for up to 6 months post-primary series and 9 months after the third dose. Following primary series vaccination, anti-SARS-CoV-2 spike IgG levels declined from months 1 to 6, while avidity increased through month 6, irrespective of the vaccine received. The third dose of either vaccine increased anti-SARS-CoV-2 spike IgG levels and avidity and appeared to enhance antibody level persistence—generating a slower rate of decline in the 3 months following the third dose compared to the decline seen after the primary series alone. The third dose of both vaccines induced significant avidity increases 1 month after vaccination compared to the avidity response 6 months post-primary series vaccination (p ≤ 0.001). A significant difference in avidity responses between the two vaccines was observed 6 months post-third dose, where the BNT162b2 recipients had higher antibody avidity levels compared to the mRNA-1273 recipients (p = 0.020). Full article

Background/Objectives: Lipid metabolism plays an important role in maternal health and fetal development. There is a gap in the knowledge of how lipid metabolism changes during pregnancy for Black women who are at a higher risk of adverse outcomes. We hypothesized that the comprehensive lipidome profiles would show variation across pregnancy indicative of requirements during gestation and fetal development. Methods: Black women were recruited at prenatal clinics. Plasma samples were collected at 8–18 weeks (T₁), 22–29 weeks (T₂), and 30–36 weeks (T₃) of pregnancy. Samples from 64 women who had term births (≥37 weeks gestation) were subjected to “shotgun” Orbitrap mass spectrometry. Mixed-effects models were used to quantify systematic changes and dimensionality reduction models were used to visualize patterns and identify reliable lipid signatures. Results: Total lipids and major lipid classes showed significant increases with the progression of pregnancy. Phospholipids and glycerolipids exhibited a gradual increase from T₁ to T₂ to T₃, while sphingolipids and total sterol lipids displayed a more pronounced increase from T₂ to T₃. Acylcarnitines, hydroxy acylcarnitines, and Lyso phospholipid levels significantly decreased from T₁ to T₃. A deviation was that non-esterified fatty acids decreased from T₁ to T₂ and increased again from T₂ to T₃, suggestive of a potential role for these lipids during the later stages of pregnancy. The fatty acids showing this trend included key fatty acids—non-esterified Linoleic acid, Arachidonic acid, Alpha-linolenic acid, Eicosapentaenoic acid, Docosapentaenoic acid, and Docosahexaenoic acid. Conclusions: Mapping lipid patterns and identifying lipid signatures would help develop intervention strategies to reduce perinatal health disparities among pregnant Black women. Full article

The chief goal of the Blood Profiling Atlas in Cancer (BloodPAC) consortium is to promote collaborative efforts that support the development and implementation of liquid biopsy tests. Here, we report the results of a pilot study conducted by three BloodPAC members that aimed to demonstrate a multisite liquid biopsy testing framework using longitudinal blood specimens from 38 patients with metastatic breast cancer. Three laboratories receiving identical samples from two clinical sites each applied a different targeted sequencing platform to analyze mutations in cell-free DNA (cfDNA). The resulting mutational profiles reflected common breast cancer alterations, including clinically actionable mutations for 40% of hormone- receptor-positive patients. In 12 genes with shared target regions across sequencing panels, perfect inter-assay concordance was also observed for mutations detected above the lowest common assay limit of detection. Whole-genome copy number profiling of cfDNA and circulating tumor cells (CTCs) further revealed marked heterogeneity in copy number alterations and cfDNA tumor fractions across patients. Additionally, comparison of tumor fraction and CTC abundance demonstrated the complementary nature of cfDNA and CTC analyses. Overall, the framework described in this study may serve as a resource for future trials aiming to identify multimodal liquid biopsy biomarkers to guide clinical care. Full article

With the aging of China’s population, the problem of pension security has become more and more prominent, and whether delayed retirement can effectively alleviate the pension fund gap and ensure the sustainability of the pension fund has become the focus of social concern. This study predicts the income and expenditure of urban workers’ basic pension insurance fund from 2021 to 2050 by constructing an actuarial model of pension insurance fund income and expenditure, and simulates the effect of delayed retirement policy. The prediction results show that under the existing system, the basic pension insurance fund for urban workers will have a shortfall for the first time in 2027, and the shortfall will expand year by year. Compared with the non-implementation of delayed retirement policy, the simulation of the implementation of a delayed retirement program delayed the emergence of the fund gap until 2029, and the forecast period of the pension fund gap significantly narrowed, indicating that delayed retirement policy has a certain positive impact on alleviating the pressure of pension payments, but delayed retirement cannot completely eliminate the pension fund gap. In view of this, this paper suggests that a progressive and flexible delayed retirement policy should be introduced as soon as possible to better adapt to the needs of different groups. At the same time, differentiated policies should be formulated for different groups of people and a pension incentive mechanism for delayed retirement should be set up to improve public acceptance of delayed retirement policy. In addition, delayed retirement policy should be combined with other measures, such as lowering the corporate contribution rate and enhancing the value-added capacity of the pension fund, so as to ensure the sustainability of the pension fund. Full article

Ensuring the tightness of buildings using self-adhesive tapes is one of the cost-effective, efficient, and reliable solutions. There is a lack of research, standards, and methodologies for construction adhesive tape, especially for assessing the functional properties of the tape after ageing. The aim of this work is to evaluate the tightness of different building surfaces and adhesive tape systems by conducting artificial ageing. It was found that adhesive tapes with an acrylic adhesive base ensured a fully sealed system. In all cases, tapes applied to surfaces such as plywood, gypsum plasterboard, cement-bonded particle board, plastered cement-bonded particle board, and plastic board provided sufficient sealing. The air permeability of the tapes on the OSB was two to seven times higher than that of the defined sealed system with other surfaces. In most cases, air permeability increased on OSB, gypsum plasterboard, and plastered cement-bonded particle board after ageing. The least problematic surface is the plastic board. In all tested cases, adequate sealing was observed after ageing, with only three of all tested tapes not providing sufficient bonding strength. Full article

The application of continuous glass fiber-reinforced polypropylene thermoplastic composites (GF/PP) is limited due to the inadequate flame retardancy of the polypropylene (PP) matrix. Apart from altering the composition of the flame retardants, the distribution modes of flame retardants also impact material performance. In this study, an alternative approach involving non-uniform distribution is proposed, namely, dispersed distribution, in which non-flame-retardant-content layers (NFRLs) and/or low-flame-retardant-content layers (LFRLs) are dispersed among high-flame-retardant-content layers (HFRLs). The mechanical, flame retardant and dielectric properties of GF/PP with intumescent flame retardant (IFR/GF/PP) are investigated comparatively under uniform, gradient, and dispersed distributions of the flame retardants. The results demonstrate that non-uniform distribution exhibits superior flame retardant performance compared to uniform distribution. Dispersed distribution enables IFR/GF/PP to attain enhanced mechanical properties and reduced dielectric constants while maintaining excellent flame-retardant properties. Full article

The efficient and timely identification of oil spill areas is crucial for ocean environmental protection. Synthetic aperture radar (SAR) is widely used in oil spill detection due to its all-weather monitoring capability. Meanwhile, existing deep learning-based oil spill detection methods mainly rely on the classical U-Net framework and have achieved impressive results. However, SAR images exhibit high noise, blurry boundaries, and irregular shapes of target areas, as well as speckles and shadows, which lead to the loss of performance in existing algorithms. In this paper, we propose a novel network architecture to achieve more precise segmentation of oil spill areas by reintroducing rich semantic contextual information before obtaining the final segmentation mask. Specifically, the proposed architecture can re-fuse feature maps from different levels at the decoder end. We design a multi-convolutional layer (MCL) module to extract basic feature information from SAR images, and a feature extraction module (FEM) module further extracts and fuses feature maps generated by the U-Net decoder at different levels. Through these operations, the network can learn rich global and local contextual information, enable sufficient interaction of feature information at different stages, enhance the model’s contextual awareness, and improve its ability to recognize complex textures and blurry boundaries, thereby enhancing the segmentation accuracy of SAR images. Compared to many U-Net based segmentation networks, our method shows promising results and achieves state-of-the-art performance on multiple evaluation metrics. Full article

Infrared (IR) imaging-based detection systems are of vital significance in the domains of early warning and security, necessitating a high level of precision and efficiency in infrared small moving target detection. IR targets often appear dim and small relative to the background and are easily buried by noise and difficult to detect. A novel high-speed spatial–temporal saliency model (HS-STSM) based on a guided filter (GF) is proposed, which innovatively introduces GF into IR target detection to extract the local anisotropy saliency in the spatial domain, and substantially suppresses the background region as well as the bright clutter false alarms present in the background. Moreover, the proposed model extracts the motion saliency of the target in the temporal domain through vectorization of IR image sequences. Additionally, the proposed model significantly improves the detection efficiency through a vectorized filtering process and effectively suppresses edge components in the background by integrating a prior weight. Experiments conducted on five real infrared image sequences demonstrate the superior performance of the model compared to existing algorithms in terms of the detection rate, noise suppression, real-time processing, and robustness to the background. Full article

Targeting the issues of slow speed and inadequate precision of optimal solution calculation for multi-user detection in complex noise environments, this paper proposes a multi-user detection algorithm based on a Hybrid Cheetah Optimizer (HCO). The algorithm first optimizes the control parameters and individual update mechanism of the Cheetah Optimizer (CO) algorithm using a nonlinear strategy to improve the uniformity and discretization of the individual search range, and then dynamically introduces a differential evolutionary algorithm into the improved selection mechanism of the CO algorithm, which is utilized to fine-tune the solution space and maintain the local diversity during the fast search process. Simulation results demonstrate that this detection algorithm not only realizes fast convergence with a very low bit error rate (BER) at eight iterations but also has obvious advantages in terms of noise immunity, resistance to far and near effects, communication capacity, etc., which greatly improves the speed and accuracy of optimal position solving for multi-user detection and can achieve the purpose of accurate solving in complex environments. Full article

Melatonin is ubiquitously present in all animals and plants, where it exerts a variety of physiological activities thanks to its antioxidant properties and its key role as the first messenger of extracellular signaling functions. Most of the clinical studies on melatonin refer to its widespread oral use as a dietary supplement to improve sleep. A far smaller number of articles describe the clinical applications of topical melatonin to treat or prevent skin disorders by exploiting its antioxidant and anti-inflammatory activities. This review focuses on the clinical studies in which melatonin was applied on the skin as a photoprotective, anti-aging, or hair growth-promoting agent. The methodologies and results of such studies are discussed to provide an overall picture of the state of the art in this intriguing field of research. The clinical studies in which melatonin was applied on the skin before exposure to radiation (UV, sunlight, and high-energy beams) were all characterized by an appropriate design (randomized, double-blind, and placebo-controlled) and strongly support its clinical efficacy in preventing or reducing skin damage such as dermatitis, erythema, and sunburn. Most of the studies examined in this review do not provide a clear demonstration of the efficacy of topical melatonin as a skin anti-aging or as a hair growth-promoting agent owing to limitations in their design and/or to the use of melatonin combined with extra active ingredients, except for one trial that suggests a possible beneficial role of melatonin in treating some forms of alopecia in women. Further research efforts are required to reach definitive conclusions concerning the actual benefits of topical melatonin to counteract skin aging and hair loss. Full article

The aim of this paper is to prove a theorem for holomorphic twisted quiver bundles over a special non-compact Gauduchon manifold, connecting the existence of $(\sigma ,\tau )$-Hermite–Yang–Mills metric in differential geometry and the analytic $(\sigma ,\tau )$-stability in algebraic geometry. The proof of the theorem relies on the flow method and the Uhlenbeck–Yau’s continuity method. Full article

The rising Greenhouse Gas (GHG) emissions stemming from the extensive use of automobiles across the globe represent a critical environmental challenge, contributing significantly to phenomena such as global warming and the deterioration of air quality. To address these challenges, there is a critical need for research and development in electric vehicles (EVs) and their associated charging infrastructure, including off-board and on-board chargers (OBCs). This paper aims to bridge the gaps in existing review literature by offering a comprehensive review of both integrated and non-integrated OBCs for EVs, based on the authors’ knowledge at the time of writing. The paper begins by outlining trends in the EV market, including voltage levels, power ratings, and relevant standards. It then provides a detailed analysis of two-level and multi-level power converter topologies, covering AC-DC power factor correction (PFC) and isolated DC-DC topologies. Subsequently, it discusses single-stage and two-stage non-integrated OBC solutions. Additionally, various categories of integrated OBCs (iOBCs) are explored, accompanied by relevant examples. The paper also includes comparison tables containing technical specifications and key characteristics for reference and analysis. Full article

Although the effect of campus landscape space on stress relief among college students has been confirmed, few existing studies have considered the impact on stress recovery from the perspective of factor combination, and the key visual elements and the most effective combination of visual elements to relieve stress are still unclear. This study attempts to conduct a natural experiment within Chinese campuses, measuring physiological indicators of stress such as heart rate (HR), frequency domain index of heart rate variability (LF/HF), skin conductance level (SCL), skin temperature (SKT), and respiratory rate (RESP) using physiological instruments. It explored the effects of visual elements and their combinations in campus landscape spaces on short-term stress relief among college students through semantic segmentation, multifactorial analysis of variance, and post hoc multiple comparison methods. Research results demonstrate that the presence of water elements in the field of vision can effectively improve the stress relief effects of landscape spaces. Reasonable combinations of natural landscape elements and artificial landscape elements in the design can also effectively promote stress relief among students. Building facade area and sky area, water area and sky area, and plant species and pavement area are three combinations of factors with the strongest interactive effects. “Natural water scenery” and “exquisite artificial” are two campus landscape design patterns most conducive to short-term stress relief. Full article

Absorptive bandpass filters (ABPFs) are highly attractive in modern microwave communication systems due to their ability to internally absorb the harmful stopband RF-power reflections. This paper reports an approach to designing quasi-elliptic ABPFs with ultra-wide reflectionless range, enhanced selectivity, and compact size. The method is realized based on a fourth-order quasi-elliptic absorptive lowpass filter (ALPF) prototype with a simplified structure. This ALPF prototype exhibits both good impedance-matching over the whole normalized frequency domain and an adjustable transmission zero close to the passband. By applying an equivalent impedance transformer model, a coupled-line-based ABPF scheme is devised from the ALPF prototype, which eliminates conventional dispersive transmission line inverters, resulting in an ultra-wide reflectionless range and a compact size. Closed-form equations are derived to support the filter synthesis. A 2.45 GHz microstrip ABPF with 30% fractional bandwidth is designed for verification. The measured minimum in-band insertion loss is 0.83 dB and the reflectionless range of return loss better than 10 dB is from DC to 12.88 GHz. Both the upper and lower stopband suppression exceed 20 dB, with the upper stopband extending up to 6.80 GHz. The upper and lower out-of-band roll-off rates are 93.9 and 121.4 dB/GHz, respectively. The overall circuit size is 0.12 λ_g². Full article

At present, heavy-metal-free quantum dot light-emitting diodes (QLEDs) have shown great potential as a research hotspot in the field of optoelectronic devices. This article reviews the research on heavy-metal-free quantum dot (QD) materials and light-emitting diode (LED) devices. In the first section, we discussed the hazards of heavy-metal-containing quantum dots (QDs), such as environmental pollution and human health risks. Next, the main representatives of heavy-metal-free QDs were introduced, such as InP, ZnE (E=S, Se and Te), CuInS₂, Ag₂S, and so on. In the next section, we discussed the synthesis methods of heavy-metal-free QDs, including the hot injection (HI) method, the heat up (HU) method, the cation exchange (CE) method, the successful ionic layer adsorption and reaction (SILAR) method, and so on. Finally, important progress in the development of heavy-metal-free QLEDs was summarized in three aspects (QD emitter layer, hole transport layer, and electron transport layer). Full article

Childhood obesity might threaten children’s current and adulthood health outcomes. Previous studies have illustrated the positive effects of physical activity on weight control; however, there is a lack of evidence on the optimal dose of physical activity. Therefore, we aimed to explore the relationship between physical activity and overweight and obesity, as well as the optimal threshold for physical activity. The median (interquartile range) and number (proportion) were used to describe the statistics. The Mann–Whitney U test and chi-square test were used for an univariable analysis. The generalized additive model with a smooth function was used to depict the preliminary relationship between physical activity and overweight and obesity. The cut-off level of physical activity was identified using AddFor algorithms, and a logistic regression model was applied to explore the multivariable relationship between physical activity and overweight and obesity after adjusting for control variables. According to the statistical analyses, 24.3% of 842 children and adolescents had overweight and obesity. The average number of days that the participants engaged in more than one hour of physical activity was three days a week. The optimal cut-off level of physical activity for the prevention of childhood overweight and obesity was 4 times a week. The participants who exercised more than four times a week (AOR(95% CI) = 0.56(0.38, 0.83), p = 0.004) were less likely to be overweight and obese. In the context of the general lack of physical activity among children and adolescents, we recommend that children and adolescents engage in 60 min of physical activity more than four times a week for a healthy weight. Full article

The association between pre-harvest sprouting (PHS) and seed coat color has long been recognized. Red-grained wheats generally exhibit greater PHS resistance compared to white-grained wheat, although variability in PHS resistance exists within red-grained varieties. Here, we conducted a genome-wide association study on a panel consisting of red-grained wheat varieties, aimed at uncovering genes that modulate PHS resistance and red color components of seed coat using digital image processing. Twelve loci associated with PHS traits were identified, nine of which were described for the first time. Genetic loci marked by SNPs AX-95172164 (chromosome 1B) and AX-158544327 (chromosome 7D) explained approximately 25% of germination index variance, highlighting their value for breeding PHS-resistant varieties. The most promising candidate gene for PHS resistance was TraesCS6B02G147900, encoding a protein involved in aleurone layer morphogenesis. Twenty-six SNPs were significantly associated with grain color, independently of the known Tamyb10 gene. Most of them were related to multiple color characteristics. Prioritization of genes within the revealed loci identified TraesCS1D03G0758600 and TraesCS7B03G1296800, involved in the regulation of pigment biosynthesis and in controlling pigment accumulation. In conclusion, our study identifies new loci associated with grain color and germination index, providing insights into the genetic mechanisms underlying these traits. Full article

Alternanthera philoxeroides and Hypophthalmichthys molitrix offer significant nutritional benefits. This study evaluates the proximate composition, amino acid profile, GC-MS analysis, FT-IR spectroscopy, SEM and EDX, and color values of edible paper sheets (EPSs) derived from Alternanthera philoxeroides incorporating different levels of Hypophthalmichthys molitrix flesh. The protein content in the EPSs varied based on fish flesh incorporation, peaking at 52.66% in Ap100/Hm300 (Non-boil). Protein and carbohydrate contents showed an inverse correlation across EPSs, with the highest carbohydrate content of 60.89% in sample Ap400/Hm0 (Boil). Lipid content was also found to correlate with H. molitrix flesh content in EPSs, ranging from 1.59% to 18.41%. Amino acid analysis identified 11 types, with methionine as the most prevalent, followed by leucine, phenylalanine, and lysine. GC-MS analysis revealed 51 bioactive compounds, including carbonic acid, hentriacontane, and various fatty acids. FT-IR analysis showed characteristic bonds, while color analysis displayed L* values ranging from 24.37 to 30.97. SEM analyses depicted the microstructure, surface view, and elemental composition of the EPSs, and EDX showed an abundance of Ca, N, K, O, C, Mg, Na, P, Cl, Mn, and Fe. Therefore, EPSs prepared from A. philoxeroides and H. molitrix could offer a promising approach for effectively utilizing aquatic biomass and providing both plant and animal nutrients to consumers. Full article

Knowledge of the composition of proteins that interact with plasma DNA will provide a better understanding of the homeostasis of circulating nucleic acids and the various modes of interaction with target cells, which may be useful in the development of gene targeted therapy approaches. The goal of the present study is to shed light on the composition and architecture of histone-containing nucleoprotein complexes (NPCs) from the blood plasma of healthy females (HFs) and breast cancer patients (BCPs) and to explore the relationship of proteins with crucial steps of tumor progression: epithelial–mesenchymal transition (EMT), cell proliferation, invasion, cell migration, stimulation of angiogenesis, and immune response. MALDI-TOF mass spectrometric analysis of NPCs isolated from blood samples using affine chromatography was performed. Bioinformatics analysis showed that the shares of DNA-binding proteins in the compositions of NPCs in normal and cancer patients are comparable and amount to 40% and 33%, respectively; in total, we identified 38 types of DNA-binding motifs. Functional enrichment analysis using FunRich 3.13 showed that, in BCP blood, the share of DNA-binding proteins involved in nucleic acid metabolism increased, while the proportion of proteins involved in intercellular communication and signal transduction decreased. The representation of NPC passenger proteins in breast cancer also changes: the proportion of proteins involved in transport increases and the share of proteins involved in energy biological pathways decreases. Moreover, in the HF blood, proteins involved in the processes of apoptosis were more represented in the composition of NPCs and in the BCP blood—in the processes of active secretion. For the first time, bioinformatics approaches were used to visualize the architecture of circulating NPCs in the blood and to show that breast cancer has an increased representation of passenger proteins involved in EMT, cell proliferation, invasion, cell migration, and immune response. Using breast cancer protein data from the Human Protein Atlas (HPA) and DEPC, we found that 86% of NPC proteins in the blood of BCPs were not previously annotated in these databases. The obtained data may indirectly indicate directed protein sorting in NPCs, which, along with extracellular vesicles, can not only be diagnostically significant molecules for liquid biopsy, but can also carry out the directed transfer of genetic material from donor cells to recipient cells. Full article

Antimicrobial photodynamic therapy (PDT) is a treatment that is gaining popularity in modern clinical medicine. However, little is known about the effect of PDT alone on reducing oral halitosis and the duration of the effect. This trial examined the effect of PDT on the tongue dorsum on reducing oral halitosis and the duration of the effect. This study was approved by the Ethics Committee of Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, and Okayama University Hospital (CRB20-015), and it was registered in the Japan Registry of Clinical Trials (jRCTs061200060). Twenty-two participants were randomly assigned to two groups: an intervention group and control group. PDT was performed in the intervention group using red laser emission and methylene blue gel on the middle and posterior area of the tongue dorsum. The concentration of volatile sulfur compounds, bacterial count on the tongue dorsum, probing pocket depth, bleeding on probing, and simplified oral debris index score were determined before and 1 week after PDT. The Mann–Whitney U test was used to assess the significance of the differences in each parameter between the two groups. We found that the hydrogen sulfide concentration and bacterial count on the tongue dorsum were decreased in the intervention group, but there was no statistically significant difference between the two groups. These results indicated that performing only PDT on the tongue dorsum may not contribute to reducing halitosis. Full article

Cancer remains a significant challenge for public healthcare systems worldwide. Within the realm of cancer treatment, considerable attention is focused on understanding the tumor microenvironment (TME)—the complex network of non-cancerous elements surrounding the tumor. Among the cells in TME, tumor-associated macrophages (TAMs) play a central role, traditionally categorized as pro-inflammatory M1 macrophages or anti-inflammatory M2 macrophages. Within the TME, M2-like TAMs can create a protective environment conducive to tumor growth and progression. These TAMs secrete a range of factors and molecules that facilitate tumor angiogenesis, increased vascular permeability, chemoresistance, and metastasis. In response to this challenge, efforts are underway to develop adjuvant therapy options aimed at reprogramming TAMs from the M2 to the anti-tumor M1 phenotype. Such reprogramming holds promise for suppressing tumor growth, alleviating chemoresistance, and impeding metastasis. Nanotechnology has enabled the development of nanoformulations that may soon offer healthcare providers the tools to achieve targeted drug delivery, controlled drug release within the TME for TAM reprogramming and reduce drug-related adverse events. In this review, we have synthesized the latest data on TAM polarization in response to TME factors, highlighted the pathological effects of TAMs, and provided insights into existing nanotechnologies aimed at TAM reprogramming and depletion. Full article