The 2023 MDPI Annual Report has
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11 pages, 2032 KiB  
Article
Unveiling the Low-Lying Spin States of [Fe3S4] Clusters via the Extended Broken-Symmetry Method
by Shibing Chu and Qiuyu Gao
Molecules 2024, 29(9), 2152; https://doi.org/10.3390/molecules29092152 (registering DOI) - 06 May 2024
Abstract
Photosynthetic water splitting, when synergized with hydrogen production catalyzed by hydrogenases, emerges as a promising avenue for clean and renewable energy. However, theoretical calculations have faced challenges in elucidating the low-lying spin states of iron–sulfur clusters, which are integral components of hydrogenases. To [...] Read more.
Photosynthetic water splitting, when synergized with hydrogen production catalyzed by hydrogenases, emerges as a promising avenue for clean and renewable energy. However, theoretical calculations have faced challenges in elucidating the low-lying spin states of iron–sulfur clusters, which are integral components of hydrogenases. To address this challenge, we employ the Extended Broken-Symmetry method for the computation of the cubane–[Fe3S4] cluster within the [FeNi] hydrogenase enzyme. This approach rectifies the error caused by spin contamination, allowing us to obtain the magnetic exchange coupling constant and the energy level of the low-lying state. We find that the Extended Broken-Symmetry method provides more accurate results for differences in bond length and the magnetic coupling constant. This accuracy assists in reconstructing the low-spin ground state force and determining the geometric structure of the ground state. By utilizing the Extended Broken-Symmetry method, we further highlight the significance of the geometric arrangement of metal centers in the cluster’s properties and gain deeper insights into the magnetic properties of transition metal iron–sulfur clusters at the reaction centers of hydrogenases. This research illuminates the untapped potential of hydrogenases and their promising role in the future of photosynthesis and sustainable energy production. Full article
(This article belongs to the Special Issue Photocatalytic Materials and Photocatalytic Reactions)
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11 pages, 1875 KiB  
Communication
A Novel Weighted Block Sparse DOA Estimation Based on Signal Subspace under Unknown Mutual Coupling
by Yulong Liu, Yingzeng Yin, Hongmin Lu and Kuan Tong
Electronics 2024, 13(9), 1790; https://doi.org/10.3390/electronics13091790 (registering DOI) - 06 May 2024
Abstract
In this paper, a novel weighted block sparse method based on the signal subspace is proposed to realize the Direction-of-Arrival (DOA) estimation under unknown mutual coupling in the uniform linear array. Firstly, the signal subspace is obtained by decomposing the eigenvalues of the [...] Read more.
In this paper, a novel weighted block sparse method based on the signal subspace is proposed to realize the Direction-of-Arrival (DOA) estimation under unknown mutual coupling in the uniform linear array. Firstly, the signal subspace is obtained by decomposing the eigenvalues of the sampling covariance matrix. Then, a block sparse model is established based on the deformation of the product of the mutual coupling matrix and the steering vector. Secondly, a suitable set of weighted coefficients is calculated to enhance sparsity. Finally, the optimization problem is transformed into a second-order cone (SOC) problem and solved. Compared with other algorithms, the simulation results of this paper have better performance on DOA accuracy estimation. Full article
(This article belongs to the Special Issue Radar System and Radar Signal Processing)
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24 pages, 8326 KiB  
Article
High Resolution Ranging with Small Sample Number under Low SNR Utilizing RIP-OMCS Strategy and AHRC l1 Minimization for Laser Radar
by Min Xue, Mengdao Xing, Yuexin Gao, Jixiang Fu, Zhixin Wu and Wangshuo Tang
Remote Sens. 2024, 16(9), 1647; https://doi.org/10.3390/rs16091647 (registering DOI) - 06 May 2024
Abstract
This manuscript presents a novel scheme to achieve high-resolution laser-radar ranging with a small sample number under low signal-to-noise ratio (SNR) conditions. To reduce the sample number, the Restricted Isometry Property-based optimal multi-channel coprime-sampling (RIP-OMCS) strategy is established. In the RIP-OMCS strategy, the [...] Read more.
This manuscript presents a novel scheme to achieve high-resolution laser-radar ranging with a small sample number under low signal-to-noise ratio (SNR) conditions. To reduce the sample number, the Restricted Isometry Property-based optimal multi-channel coprime-sampling (RIP-OMCS) strategy is established. In the RIP-OMCS strategy, the data collected across multiple channels with very low coprime-sampling rates can record accurate range information on each target. Further, the asynchronous problem caused by channel sampling-time errors is considered. The sampling-time errors are estimated using the cross-correlation function. After canceling the asynchronous problem, the data collected by multiple channels are then merged into non-uniform sampled signals. Using data combination, target-range estimation is converted into an optimization problem of sparse representation consisting of a non-uniform Fourier dictionary. This optimization problem is solved using adaptive hybrid re-weighted constraint (AHRC) l1 minimization. Two constraints are formed from statistical attributes of the targets and clutter. Moreover, as the detailed characteristics of the target, clutter, and noise are unknown before the solution, the two constraints can be adaptively modified, which guarantees that l1 minimization obtains the high-resolution range profile and accurate distance of all targets under a low SNR. Our experiments confirmed the effectiveness of the proposed method. Full article
(This article belongs to the Topic Radar Signal and Data Processing with Applications)
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23 pages, 16364 KiB  
Article
Mapping the Continuous Cover of Invasive Noxious Weed Species Using Sentinel-2 Imagery and a Novel Convolutional Neural Regression Network
by Fei Xing, Ru An, Xulin Guo and Xiaoji Shen
Remote Sens. 2024, 16(9), 1648; https://doi.org/10.3390/rs16091648 (registering DOI) - 06 May 2024
Abstract
Invasive noxious weed species (INWS) are typical poisonous plants and forbs that are considered an increasing threat to the native alpine grassland ecosystems in the Qinghai–Tibetan Plateau (QTP). Accurate knowledge of the continuous cover of INWS across complex alpine grassland ecosystems over a [...] Read more.
Invasive noxious weed species (INWS) are typical poisonous plants and forbs that are considered an increasing threat to the native alpine grassland ecosystems in the Qinghai–Tibetan Plateau (QTP). Accurate knowledge of the continuous cover of INWS across complex alpine grassland ecosystems over a large scale is required for their control and management. However, the cooccurrence of INWS and native grass species results in highly heterogeneous grass communities and generates mixed pixels detected by remote sensors, which causes uncertainty in classification. The continuous coverage of INWS at the pixel level has not yet been achieved. In this study, objective 1 was to test the capability of Senginel-2 imagery at estimating continuous INWS cover across complex alpine grasslands over a large scale and objective 2 was to assess the performance of the state-of-the-art convolutional neural network-based regression (CNNR) model in estimating continuous INWS cover. Therefore, a novel CNNR model and a random forest regression (RFR) model were evaluated for estimating INWS continuous cover using Sentinel-2 imagery. INWS continuous cover was estimated directly from Sentinel-2 imagery with an R2 ranging from 0.88 to 0.93 using the CNNR model. The RFR model combined with multiple features had a comparable accuracy, which was slightly lower than that of the CNNR model, with an R2 of approximately 0.85. Twelve green band-, red-edge band-, and near-infrared band-related features had important contributions to the RFR model. Our results demonstrate that the CNNR model performs well when estimating INWS continuous cover directly from Sentinel-2 imagery, and the RFR model combined with multiple features derived from the Sentinel-2 imager can also be used for INWS continuous cover mapping. Sentinel-2 imagery is suitable for mapping continuous INWS cover across complex alpine grasslands over a large scale. Our research provides information for the advanced mapping of the continuous cover of invasive species across complex grassland ecosystems or, more widely, terrestrial ecosystems over large spatial areas using remote sensors such as Sentinel-2. Full article
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13 pages, 1278 KiB  
Article
Assessment of Suicide Risk in Patients with Depressive Episodes Due to Affective Disorders and Borderline Personality Disorder: A Pilot Comparative Study
by Elena Rudolfovna Isaeva, Daria Maksimovna Ryzhova, Anna Vladimirovna Stepanova and Ivo Nestorov Mitrev
Brain Sci. 2024, 14(5), 463; https://doi.org/10.3390/brainsci14050463 (registering DOI) - 06 May 2024
Abstract
This study assessed suicidal risk in patients suffering from non-psychotic depressive disorders within various clinical and nosological forms (F31–F34 mood disorders and F60.31—emotionally unstable personality disorder). Clinical and psychological features were presented, as well as predictors of suicidal risk in patients of these [...] Read more.
This study assessed suicidal risk in patients suffering from non-psychotic depressive disorders within various clinical and nosological forms (F31–F34 mood disorders and F60.31—emotionally unstable personality disorder). Clinical and psychological features were presented, as well as predictors of suicidal risk in patients of these groups. We performed a comparative analysis of the anxiety and depression level, the level of mental pain, fear of death and the severity of anti-suicidal motives in patients with affective disorders and borderline personality disorder (BPD). Based on the results, 100% of patients in these clinical nosological groups were found to have a high level of suicidal risk. Patients with affective disorders have weak anti-suicidal motives and are not fully aware of the consequences of their own death. Patients with BPD have a higher suicidal risk than patients with affective disorders; they are characterized by less pronounced social orientation, demonstrativeness, self-centeredness, less pronounced levels of anxiety and fear of death. Full article
(This article belongs to the Special Issue Anxious Brain: Stress Influence on the Nervous System)
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18 pages, 3900 KiB  
Review
The Antiviral Activity of Interferon-Induced Transmembrane Proteins and Virus Evasion Strategies
by Jingjing Wang, Yuhang Luo, Harshita Katiyar, Chen Liang and Qian Liu
Viruses 2024, 16(5), 734; https://doi.org/10.3390/v16050734 (registering DOI) - 06 May 2024
Abstract
Interferons (IFNs) are antiviral cytokines that defend against viral infections by inducing the expression of interferon-stimulated genes (ISGs). Interferon-inducible transmembrane proteins (IFITMs) 1, 2, and 3 are crucial ISG products and members of the CD225 protein family. Compelling evidence shows that IFITMs restrict [...] Read more.
Interferons (IFNs) are antiviral cytokines that defend against viral infections by inducing the expression of interferon-stimulated genes (ISGs). Interferon-inducible transmembrane proteins (IFITMs) 1, 2, and 3 are crucial ISG products and members of the CD225 protein family. Compelling evidence shows that IFITMs restrict the infection of many unrelated viruses by inhibiting the virus–cell membrane fusion at the virus entry step via the modulation of lipid composition and membrane properties. Meanwhile, viruses can evade IFITMs’ restrictions by either directly interacting with IFITMs via viral glycoproteins or by altering the native entry pathway. At the same time, cumulative evidence suggests context-dependent and multifaceted roles of IFITMs in modulating virus infections and cell signaling. Here, we review the diverse antiviral mechanisms of IFITMs, the viral antagonizing strategies, and the regulation of IFITM activity in host cells. The mechanisms behind the antiviral activity of IFITMs could aid the development of broad-spectrum antivirals and enhance preparedness for future pandemics. Full article
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14 pages, 5726 KiB  
Article
Coupled Mode Design of Low-Loss Electromechanical Phase Shifters
by Nathnael S. Abebe, Sunil Pai, Rebecca L. Hwang, Payton Broaddus, Yu Miao and Olav Solgaard
Micro 2024, 4(2), 334-347; https://doi.org/10.3390/micro4020021 (registering DOI) - 06 May 2024
Abstract
Micro-electromechanical systems (MEMS) have the potential to provide low-power phase shifting in silicon photonics, but techniques for designing low-loss devices are necessary for adoption of the technology. Based on coupled mode theory (CMT), we derive analytical expressions relating the loss and, in particular, [...] Read more.
Micro-electromechanical systems (MEMS) have the potential to provide low-power phase shifting in silicon photonics, but techniques for designing low-loss devices are necessary for adoption of the technology. Based on coupled mode theory (CMT), we derive analytical expressions relating the loss and, in particular, the phase-dependent loss, to the geometry of the MEMS phase shifters. The analytical model explains the loss mechanisms of MEMS phase shifters and enables simple optimization procedures. Based on that insight, we propose phase shifter geometries that minimize coupling power out of the waveguide. Minimization of the loss is based on mode orthogonality of a waveguide and phase shifter modes. We numerically model such geometries for a silicon nitride MEMS phase shifter over a silicon nitride waveguide, predicting less than −1.08 dB loss over a 2π range and −0.026 dB loss when optimized for a π range. We demonstrate this design framework with a custom silicon nitride process and achieve −0.48 dB insertion loss and less than 0.05 dB transmission variation over a π phase shift. Our work demonstrates the strength of the coupled mode approach for the design and optimization of MEMS phase shifters. Full article
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29 pages, 4148 KiB  
Review
Decoding Near Synonyms in Pedestrianization Research: A Numerical Analysis and Summative Approach
by Hisham Abusaada and Abeer Elshater
Urban Sci. 2024, 8(2), 45; https://doi.org/10.3390/urbansci8020045 (registering DOI) - 06 May 2024
Abstract
Pedestrianization is a significant discourse focus within urban planning and design research. However, the need for more clarity from the inconsistent use of near-synonym concepts or terms necessitates attention. This review article addresses this issue through a comprehensive analysis of synonym proliferation in [...] Read more.
Pedestrianization is a significant discourse focus within urban planning and design research. However, the need for more clarity from the inconsistent use of near-synonym concepts or terms necessitates attention. This review article addresses this issue through a comprehensive analysis of synonym proliferation in pedestrian research, culminating in developing a robust “near synonymous toolkit” and “synonym selection framework”. Employing a linear snowball sampling technique, numerical analysis, and a qualitative content analysis-based summative approach, we examined sixteen peer-reviewed articles from 11 scientific journals. Through systematic classification based on consistency and variability, the summative review identifies three primary groups of near synonyms: dominant and widely utilized conceptual or terminological near synonymy in pedestrianization in the urban planning and design literature, near synonyms directly associated with a pedestrian, pedestrianize, and those indirectly linked to another conceptual or terminological synonymy. Further analysis delves into the nature of near-synonym concepts or terms, revealing three discernible patterns: the use of distinct, precise concepts or terms with near-synonym meanings, similar concepts or terms conveying divergent meanings, and the juxtaposition of unrelated vocabulary lacking semantic resemblance. These insights illuminate semantic relationships within the studied vocabulary, underscoring the importance of addressing inconsistency for clarity, precision, and coherence in scientific discourse. By offering practical guidance through the proposed framework, this study empowers academic researchers to navigate synonym selection adeptly, thereby enhancing the caliber of scholarly writing in urban planning and design. Full article
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14 pages, 5650 KiB  
Article
Glycyrrhizic Acid Nanoparticles Subside the Activity of Methicillin-Resistant Staphylococcus aureus by Suppressing PBP2a
by Patricia Rijo, Tamer M. M. Abuamara, Lashin Saad Ali Lashin, Sherif A. Kamar, Vera M. S. Isca, Tahseen S. Mohammed, Mohamed S. M. Abdrabo, Mohamed A. Amin, Ahmed I. Abd El Maksoud and Amr Hassan
Pharmaceuticals 2024, 17(5), 589; https://doi.org/10.3390/ph17050589 (registering DOI) - 06 May 2024
Abstract
Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA) are classified as high-risk infections that can lead to death, particularly among older individuals. Nowadays, plant nanoparticles such as glycyrrhizic acid are recognized as efficient bactericides against a wide range of bacterial strains. Recently, scientists have [...] Read more.
Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA) are classified as high-risk infections that can lead to death, particularly among older individuals. Nowadays, plant nanoparticles such as glycyrrhizic acid are recognized as efficient bactericides against a wide range of bacterial strains. Recently, scientists have shown interest in plant extract nanoparticles, derived from natural sources, which can be synthesized into nanomaterials. Interestingly, glycyrrhizic acid is rich in antioxidants as well as antibacterial agents, and it exhibits no adverse effects on normal cells. In this study, glycyrrhizic acid nanoparticles (GA-NPs) were synthesized using the hydrothermal method and characterized through physicochemical techniques such as UV–visible spectrometry, DLS, zeta potential, and TEM. The antimicrobial activity of GA-NPs was investigated through various methods, including MIC assays, anti-biofilm activity assays, ATPase activity assays, and kill-time assays. The expression levels of mecA, mecR1, blaR1, and blaZ genes were measured by quantitative RT-qPCR. Additionally, the presence of the penicillin-binding protein 2a (PBP2a) protein of S. aureus and MRSA was evaluated by a Western blot assay. The results emphasized the fabrication of GA nanoparticles in spherical shapes with a diameter in the range of 40–50 nm. The data show that GA nanoparticles exhibit great bactericidal effectiveness against S. aureus and MRSA. The treatment with GA-NPs remarkably reduces the expression levels of the mecA, mecR1, blaR1, and blaZ genes. PBP2a expression in MRSA was significantly reduced after treatment with GA-NPs. Overall, this study demonstrates that glycyrrhizic acid nanoparticles have potent antibacterial activity, particularly against MRSA. This research elucidates the inhibition mechanism of glycyrrhizic acid, which involves the suppressing of PBP2a expression. This work emphasizes the importance of utilizing plant nanoparticles as effective antimicrobial agents against a broad spectrum of bacteria. Full article
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8 pages, 412 KiB  
Article
Accelerated Fractionated Radiation Therapy for Localized Glottic Carcinoma
by Tatsuji Mizukami, Kentaro Yamagishi, Masaki Tobikawa, Akira Nakazato, Hideharu Abe, Yuka Morita and Jun-ichi Saitoh
Curr. Oncol. 2024, 31(5), 2636-2643; https://doi.org/10.3390/curroncol31050198 (registering DOI) - 06 May 2024
Abstract
Background: The aim of this study is to examine the outcomes of an accelerated fractionated irradiation for N0 glottic carcinoma. Methods: In this retrospective analysis, 29 patients with N0 glottic carcinoma treated by radiation therapy were enrolled. Thirteen patients had T1a disease, six [...] Read more.
Background: The aim of this study is to examine the outcomes of an accelerated fractionated irradiation for N0 glottic carcinoma. Methods: In this retrospective analysis, 29 patients with N0 glottic carcinoma treated by radiation therapy were enrolled. Thirteen patients had T1a disease, six had T1b disease, and ten had T2 disease. A fractional dose of 2.1 Gy was administered to seven patients. The total doses were 65.1 and 67.2 Gy in four and three patients, respectively. A fractional dose of 2.25 Gy was administered to 22 patients. The total doses were 63 and 67.5 Gy in 21 patients and 1 patient with T2 disease, respectively. Additionally, 13 patients underwent the use of TS-1 (80–100 mg per day). Results: The median follow-up period was 33 months, and the 3-year local control rate was 95.6%. No patient had a lymph node or distant recurrence. As acute adverse events, grades 2 and 3 dermatitis were observed in 18 patients and 1 patient, and grades 2 and 3 mucositis were observed in 15 patients and 1 patient. As a late adverse event, one patient required tracheotomy because of laryngeal edema occurring. Conclusions: Accelerated fractionated irradiation may be an option in the radiation therapy of N0 glottic carcinoma because of its ability to shorten the treatment time. Full article
(This article belongs to the Section Head and Neck Oncology)
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19 pages, 10133 KiB  
Article
Research on the Identification of Nonlinear Wheel–Rail Adhesion Characteristics Model Parameters in Electric Traction System Based on the Improved TLBO Algorithm
by Weiwei Gan, Xufeng Zhao, Dong Wei, Zhonghao Bai, Rongjun Ding, Kan Liu and Xueming Li
Electronics 2024, 13(9), 1789; https://doi.org/10.3390/electronics13091789 (registering DOI) - 06 May 2024
Abstract
The wheel–rail adhesion is one of the key factors limiting the traction performance of railway vehicles. To meet the adhesion optimization needs and rapidly obtain wheel–rail creep characteristics under specific operating conditions, an engineering identification method for wheel–rail adhesion characteristics based on a [...] Read more.
The wheel–rail adhesion is one of the key factors limiting the traction performance of railway vehicles. To meet the adhesion optimization needs and rapidly obtain wheel–rail creep characteristics under specific operating conditions, an engineering identification method for wheel–rail adhesion characteristics based on a nonlinear model is proposed. The proposed method, built upon the traditional Teaching-Learning-Based Optimization (TLBO) algorithm, has been adapted to the specific nature of nonlinear wheel–rail adhesion model parameters identification, enhancing both the search speed in the early stages and the search accuracy in the later stages of the algorithm. The proposed identification algorithm is validated using experimental data from the South African 22E dual-flow locomotive. The validation results demonstrate that the proposed identification algorithm can obtain a nonlinear wheel–rail adhesion characteristics model with an average adhesion coefficient error of around 0.01 within 50 iteration steps. These validation results indicate promising prospects for the engineering practice of the proposed algorithm. Full article
(This article belongs to the Special Issue Control and Optimization of Power Converters and Drives)
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10 pages, 13238 KiB  
Article
Dead Zone Fault Detection Optimization Method for Few-Mode Fiber Links Based on Unexcited Coupled Higher-Order Modes
by Feng Liu, Tianle Gu and Zicheng Huang
Photonics 2024, 11(5), 433; https://doi.org/10.3390/photonics11050433 (registering DOI) - 06 May 2024
Abstract
The traditional single-mode fiber (SMF) optical time domain reflectometer (OTDR) may not be able to accurately detect and locate fault events in the dead zone of few-mode fiber (FMF) links. This paper introduces the concept of higher-order spatial mode detection dimensions unique to [...] Read more.
The traditional single-mode fiber (SMF) optical time domain reflectometer (OTDR) may not be able to accurately detect and locate fault events in the dead zone of few-mode fiber (FMF) links. This paper introduces the concept of higher-order spatial mode detection dimensions unique to FMF, combined with the spatial mode coupling characteristics between modes. The Fresnel reflection from the end face of the fiber, the interior of the circulator, and the connector only occurs in the spatial mode of the injected optical pulse. The Rayleigh backscattering, which reflects the fault distribution characteristics of FMF links, can be detected by non-excited higher-order spatial modes. The proposed method can completely overcome the traditional OTDR dead zone. In this paper, the six-mode fiber is taken as an example for experimental verification. The detection optical pulse is injected into the fundamental mode LP01, and the Rayleigh backscattering of LP11a, LP11b, LP21a, LP21b, and LP02 higher-order spatial mode are collected and analyzed to accurately detect and locate the fusion splice fault event at 100 m and 500 m in the dead zone. Full article
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18 pages, 6538 KiB  
Article
A Description of the New Hybodont Shark Genus, Columnaodus, from the Burlington and Keokuk Limestones (Carboniferous, Mississippian, Osagean) of Illinois and Iowa, USA
by David Cicimurri, Charles Ciampaglio, Matthew Hoenig, Ryan Shell, Lauren Fuelling, David Peterman, Daniel A. Cline and Stephen Jacquemin
Diversity 2024, 16(5), 276; https://doi.org/10.3390/d16050276 (registering DOI) - 06 May 2024
Abstract
Bonebeds occurring in exposures of the Burlington and Keokuk Limestones (Mississippian/Osagean) along the Iowa and Illinois border (USA) contain an abundant and diverse collection of chondrichthyan remains that includes teeth, spines, denticles, and coprolites. These remains represent cochliodont, hybodont, petalodont, ctenacanthid, symmoriid, and [...] Read more.
Bonebeds occurring in exposures of the Burlington and Keokuk Limestones (Mississippian/Osagean) along the Iowa and Illinois border (USA) contain an abundant and diverse collection of chondrichthyan remains that includes teeth, spines, denticles, and coprolites. These remains represent cochliodont, hybodont, petalodont, ctenacanthid, symmoriid, and acanthodian (stem chondrichthyan) taxa. The thickest of these beds, herein referred to as the Burlington–Keokuk bonebed, occurs at the top of the Burlington Limestone and presents a remarkable opportunity to study the assemblage of mid-continent, Middle Mississippian chondrichthyans. Bulk matrix samples of this bonebed were collected from two quarries (Biggsville Quarry, Biggsville, IL, USA, and Nelson Quarry, Mediapolis, IA, USA) and disaggregated. Among the multitude of previously known taxa, several teeth represented a new genus and species of hybodont shark. Herein, we describe these teeth as Columnaodus witzkei (gen. et sp. nov.), a hybodontiform with dental features comparable to unnamed specimens reported from elsewhere. Full article
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22 pages, 2893 KiB  
Article
Micropropagation and Genetic Fidelity of Fegra Fig (Ficus palmata Forssk.) and Grafting Compatibility of the Regenerated Plants with Ficus carica
by Ahmed Ali Al-Aizari, Yaser Hassan Dewir, Abdel-Halim Ghazy, Abdullah Al-Doss and Rashid Sultan Al-Obeed
Plants 2024, 13(9), 1278; https://doi.org/10.3390/plants13091278 (registering DOI) - 06 May 2024
Abstract
Ficus palmata is an important fig species that produces edible and nutritious fruit and possesses several therapeutic uses. This study reports an effective method for the micropropagation of F. palmata using nodal explants. In vitro shoots were cultured for 7 weeks onto MS [...] Read more.
Ficus palmata is an important fig species that produces edible and nutritious fruit and possesses several therapeutic uses. This study reports an effective method for the micropropagation of F. palmata using nodal explants. In vitro shoots were cultured for 7 weeks onto MS medium fortified with different concentrations of cytokinins, light intensities, sucrose concentrations, and light/dark incubation treatments. Optimal axillary shoot proliferation (10.9 shoots per explant) was obtained on a medium containing 30 g/L sucrose and supplemented with 2 mg/L 6-benzylaminopurine (BAP) under 35 μmol/m2/s light intensity. Dark incubation limited the foliage growth but favored shoot elongation and rooting compared with light incubation. Elongated shoots, under dark conditions, were rooted (100%; 6.67 roots per explant) onto MS medium containing 1 mg/L indole-3-acetic acid (IAA) and 1.5 g/L activated charcoal. The micropropagated plantlets were acclimatized with a 95% survival rate. In this study, the genetic fidelity of micropropagated F. palmata clones along with their mother plant was tested using randomly amplified polymorphic DNA (RAPD), inter-simple sequence repeats (ISSR), and start codon targeted (SCoT) molecular markers. The genetic similarity between the micropropagated plantlets and the mother plant of F. palmata was nearly 95.9%, assuring high uniformity and true-to-type regenerated plants. Using micropropagated F. palmata plantlets as a rootstock proved appropriate for the grafting F. carica ‘Brown Turkey’. These findings contribute to the commercial propagation and production of the fig crop. Full article
(This article belongs to the Section Plant Genetics, Genomics and Biotechnology)
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18 pages, 4448 KiB  
Article
Impact of New Energy Vehicle Charging Point Subsidy Policy on Subway Demand: Evidence from Beijing’s Real Estate Market
by Yilin Bi, Jiangwei Liu, Zhuang Liu and Suhao Wei
Sustainability 2024, 16(9), 3874; https://doi.org/10.3390/su16093874 (registering DOI) - 06 May 2024
Abstract
New energy vehicles (NEVs) offer a sustainable private transportation alternative. Charging points are the source of power for NEVs; thus, their construction can significantly lower the costs associated with their use, thereby encouraging their adoption. This could potentially impact the subway demand, which [...] Read more.
New energy vehicles (NEVs) offer a sustainable private transportation alternative. Charging points are the source of power for NEVs; thus, their construction can significantly lower the costs associated with their use, thereby encouraging their adoption. This could potentially impact the subway demand, which is reflected by the relationship between housing prices and subway proximity in this paper, leading to a decrease in the premium for properties near subway stations. Utilizing a comprehensive data set of 599,916 housing transactions in Beijing and a difference-in-differences approach based on the hedonic price model, we found that China’s NEV charging point subsidy policy significantly decreases the subway premium of housing prices and mitigates housing price disparities. Furthermore, we explored the spatial heterogeneity of this impact, finding that the policy has less influence on residents living near the city center. Our findings indicate that the policy has resulted in a considerable decrease in the subway premium, ranging from ¥19,217 to ¥55,936 ($2745 to $7991) per transaction, which is equivalent to the annual income for an average individual at the time of the policy. The results address the far-reaching implications and significant role of NEV development in urban transportation. Full article
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19 pages, 4721 KiB  
Article
Stimulating Mesoporous Characteristics of Activated Carbon through Pyrolysis of Compacted Hydroxyethyl Cellulose—A Showcase for H2S Removal
by Fuxiang Chen and Liang Hong
C 2024, 10(2), 43; https://doi.org/10.3390/c10020043 (registering DOI) - 06 May 2024
Abstract
Activated carbon (AC) serves as extensively researched adsorbents, with numerous established methods for their preparation. This study originated from the hypothesis that compressing a hydrocarbon substance to create a densely compacted pellet, known as pelletizing, would enhance the development of porous features of [...] Read more.
Activated carbon (AC) serves as extensively researched adsorbents, with numerous established methods for their preparation. This study originated from the hypothesis that compressing a hydrocarbon substance to create a densely compacted pellet, known as pelletizing, would enhance the development of porous features of the resulting AC. The anticipated enhancement is attributed to the rise in spatial proximity amidst HEC polymer chains within the bulk of the pellet, which facilitates aromatization both in extent and functionality. 2-Hydroxyethyl cellulose (HEC) pellets were prepared by adjusting the duration of load holding, aiming to increase the packing density of HEC polymer chains via creeping. The BET analysis of the resulting AC samples demonstrates the efficacy of compression on HEC pellets in enhancing their porous properties. The FE-SEM study revealed diverse AC surface morphologies that are associated with a set of specific pelletizing conditions. The 13C NMR spectroscopy for carbon skeletons, FT-IR spectroscopy for organic functionality, and XPS spectroscopy for surface composition collectively report the leverage of compression treatment before pyrolyzing HEC pellets. Furthermore, the assessment of hydrogen sulfide adsorption by the resulting AC samples revealed distinctive breakthrough curves, providing validation for the proposed compression effect. Full article
(This article belongs to the Section Carbon Materials and Carbon Allotropes)
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18 pages, 620 KiB  
Article
Optimizing Requirements Prioritization for IoT Applications Using Extended Analytical Hierarchical Process and an Advanced Grouping Framework
by Sarah Kaleem, Muhammad Asim, Mohammed El-Affendi and Muhammad Babar
Future Internet 2024, 16(5), 160; https://doi.org/10.3390/fi16050160 (registering DOI) - 06 May 2024
Abstract
Effective requirement collection and prioritization are paramount within the inherently distributed nature of the Internet of Things (IoT) application. Current methods typically categorize IoT application requirements subjectively into inessential, desirable, and mandatory groups. This often leads to prioritization challenges, especially when dealing with [...] Read more.
Effective requirement collection and prioritization are paramount within the inherently distributed nature of the Internet of Things (IoT) application. Current methods typically categorize IoT application requirements subjectively into inessential, desirable, and mandatory groups. This often leads to prioritization challenges, especially when dealing with requirements of equal importance and when the number of requirements grows. This increases the complexity of the Analytical Hierarchical Process (AHP) to O(n2) dimensions. This research introduces a novel framework that integrates an enhanced AHP with an advanced grouping model to address these issues. This integrated approach mitigates the subjectivity found in traditional grouping methods and efficiently manages larger sets of requirements. The framework consists of two main modules: the Pre-processing Module and the Prioritization Module. The latter includes three units: the Grouping Processing Unit (GPU) for initial classification using a new grouping approach, the Review Processing Unit (RPU) for post-grouping assessment, and the AHP Processing Unit (APU) for final prioritization. This framework is evaluated through a detailed case study, demonstrating its ability to effectively streamline requirement prioritization in IoT applications, thereby enhancing design quality and operational efficiency. Full article
(This article belongs to the Special Issue Artificial Intelligence-Enabled Internet of Things (IoT))
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10 pages, 525 KiB  
Article
Efficacy of a Novel Prophylactic Scheme of Fosfomycin Trometamol in Patients Undergoing Endoscopic Surgery for Benign Prostatic Hyperplasia: Findings from a Prospective Monocentric Single-Arm Study
by Pasquale Maria Berrino, Milo Gatti, Valeria Rotaru, Lorenzo Bianchi, Fabio Tumietto, Elena Sora, Riccardo Schiavina, Eugenio Brunocilla, Pierluigi Viale and Federico Pea
Antibiotics 2024, 13(5), 424; https://doi.org/10.3390/antibiotics13050424 (registering DOI) - 06 May 2024
Abstract
This study aimed to assess the efficacy of a novel prophylactic scheme of fosfomycin trometamol in patients undergoing elective HoLEP (holmium laser enucleation of the prostate) or TURP (transurethral resection of the prostate) procedures for treating benign prostatic hyperplasia. Patients affected by benign [...] Read more.
This study aimed to assess the efficacy of a novel prophylactic scheme of fosfomycin trometamol in patients undergoing elective HoLEP (holmium laser enucleation of the prostate) or TURP (transurethral resection of the prostate) procedures for treating benign prostatic hyperplasia. Patients affected by benign prostatic hyperplasia and undergoing elective HoLEP or TURP procedures during the period February 2022–June 2023 were prospectively enrolled. Two 3 g oral fosfomycin trometamol doses 12 h apart were administered at 8.00 p.m. on day −1 (i.e., the day before HoLEP or TURP procedure) and at 8.00 a.m. on day 0 (i.e., the day of the surgical procedure). The following outcomes were assessed: prevalence of fever occurring in the first 48 h after surgical procedure; prevalence of urological complications occurring after the surgical procedure; prevalence of proven urinary tract infections (UTIs) and/or bloodstream infections (BSIs) at 14 days post-procedure; and prevalence of emergency department admission for UTI-related sepsis at 14 days post-procedure. Univariate analysis comparing patients with and without proven UTI, BSI, or emergency department admission at 14 days post-procedure was carried out. Overall, 96 patients (median age 70 years) undergoing HoLEP (82.3%) or TURP (17.7%) were prospectively included. Median (IQR) time of surgical procedure after the morning fosfomycin dose was 226.5 min (range 88.5–393.75 min). Fever in the post-surgical 48 h occurred in 3/96 patients (3.1%). Prevalence of proven UTI at 14 days was as low as 1.0% (1/96), whereas no patient had proven BSI or UTI-related sepsis requiring emergency department admission at 14 days. Our findings support the contention that a prophylactic scheme based on two doses of fosfomycin trometamol 12 h apart before surgical intervention may represent a valuable strategy for preventing infectious complications in urologic patients undergoing HoLEP or TURP. Larger definitive confirmatory studies are warranted. Full article
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11 pages, 1835 KiB  
Communication
The Effect of κ-Carrageenan on Porcine Sperm Cryo-Survival
by Areeg Almubarak, Eunji Kim, Il-Jeoung Yu, Hanseul Park and Yubyeol Jeon
Animals 2024, 14(9), 1387; https://doi.org/10.3390/ani14091387 (registering DOI) - 06 May 2024
Abstract
κ-Carrageenan is a sulfated polysaccharide from red seaweed with substantial antioxidant activities. This study aimed to investigate the effect of κ-Carrageenan treatment on frozen–thawed (FT) porcine semen quality. Therefore, the spermatozoa were diluted and cryopreserved in a freezing extender supplemented with 0 (control), [...] Read more.
κ-Carrageenan is a sulfated polysaccharide from red seaweed with substantial antioxidant activities. This study aimed to investigate the effect of κ-Carrageenan treatment on frozen–thawed (FT) porcine semen quality. Therefore, the spermatozoa were diluted and cryopreserved in a freezing extender supplemented with 0 (control), 0.2, 0.4, 0.6, and 0.8 mg/mL κ-Carrageenan. Sperm kinematics were assessed immediately after thawing (AT) and post-incubation for 120 min. The viability, acrosome integrity, lipid peroxidation, mitochondrial membrane potential (MMP), and intracellular caspase activity were measured AT. The results indicated that 0.2 mg/mL κ-Carrageenan increased total and progressive motility AT and post-incubation for 120 min (p < 0.05). Moreover, the viable sperm percentage and MMP after 0.2 mg/mL treatment were higher than those after control and other κ-Carrageenan concentration treatments. The proportion of acrosome-intact spermatozoa was significantly higher after 0.2 and 0.4 mg/mL κ-Carrageenan treatment than that after control and other κ-Carrageenan concentration treatments. The intracellular caspase activity was not significantly different among the experimental groups. However, the MDA concentration after 0.2 mg/mL κ-Carrageenan treatment was lower (p < 0.05) than that after the control treatment. Taken together, adding κ-Carrageenan to the porcine semen freezing extender improved the FT sperm quality mainly by influencing membrane stability and protecting against oxidative stress. Full article
(This article belongs to the Section Animal Reproduction)
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18 pages, 10693 KiB  
Article
Mesenteric Lymphatic B Cells Migrate to the Intestine and Aggravate DSS-Induced Colitis via the CXCR5–CXCL13 Axis
by Yu Zhang, Zhe Wu, Qinghe Zhao, Yaming Liu, Qing Huang, Menglei Zhang, Shuolei Li, Di Wang, Na Li, Yujing Chi and Yulan Liu
Biology 2024, 13(5), 322; https://doi.org/10.3390/biology13050322 (registering DOI) - 06 May 2024
Abstract
The pathogenesis of inflammatory bowel disease (IBD) is still unknown. Mesenteric lymphatics (MLs), which are closely related to the intestine in both anatomy and physiology, have been suggested to be involved in IBD. In the present study, we aim to investigate the effects [...] Read more.
The pathogenesis of inflammatory bowel disease (IBD) is still unknown. Mesenteric lymphatics (MLs), which are closely related to the intestine in both anatomy and physiology, have been suggested to be involved in IBD. In the present study, we aim to investigate the effects of ML immune cells on IBD and explore the potential associated mechanisms. Acute colitis was induced in rats using dextran sulfate sodium salt (DSS). Mesenteric lymphangiogenesis, ML stenosis, and dilation were observed, with an increased proportion of MLB cells in DSS-induced colitis rats. The adoptive transfer of B cells isolated from ML (MLB) was employed to investigate their effects on colitis. MLB cells derived from DSS-induced colitis rats exhibited a higher propensity to migrate to the intestine. The proportion of colonic T cells was altered, along with the aggravated colitis induced by the adoptive transfer of MLB cells derived from DSS-induced colitis rats. RNA sequencing revealed increased Cxcr5 expression in MLB cells from colitis rats, while real-time PCR indicated an upregulation of its ligand Cxcl13 in the colon of colitis rats. These findings suggest that MLB cells may migrate to the intestine and aggravate colitis. In summary, colonic T cells respond to MLB cells from colitis rats, and MLB cells aggravate DSS-induced colitis via the CXCR5–CXCL13 axis. Full article
(This article belongs to the Special Issue Gut Immunity, Inflammation, and Allergy)
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17 pages, 1083 KiB  
Article
Study on the Influence of Host–Guest Interaction on Tourists’ Pro-Environment Behavior: Evidence from Taishan National Forest Park in China
by Feifei Lu, Bingnan Wang, Juan Bi and Weiya Guo
Forests 2024, 15(5), 813; https://doi.org/10.3390/f15050813 (registering DOI) - 06 May 2024
Abstract
This study explores the influence of host–guest interaction on tourists’ pro-environment behavior. On the one hand, the experience attribute of host–guest interaction’s influence on tourists’ experiential value is sorted out. On the other hand, the relationship attribute of host–guest interaction’s activation effect on [...] Read more.
This study explores the influence of host–guest interaction on tourists’ pro-environment behavior. On the one hand, the experience attribute of host–guest interaction’s influence on tourists’ experiential value is sorted out. On the other hand, the relationship attribute of host–guest interaction’s activation effect on tourists’ personal norms is identified. Based on social exchange theory and normative activation theory, a structural equation model was established to depict the transmission mechanism from host–guest interaction to tourists’ pro-environment behavior. The data were collected from tourists in Taishan National Forest Park (n = 499). The results indicated that host–guest interaction quality activated tourists’ personal norms through consequence awareness, thus promoting tourists’ pro-environment behavior. Meanwhile, the quality of host–guest interaction positively influenced tourists’ pro-environment behavior through emotional experience value. Host–guest interaction quantity promoted tourists’ pro-environment behavior by activating personal norms through responsibility ascription. In addition, although frequent host–guest interactions can enhance the social experience and functional experience value of tourists, the latter two cannot stimulate tourists’ pro-environmental behavior. This study provides practical implications for promoting the sustainable development of national forest parks. Full article
(This article belongs to the Special Issue Economy and Sustainability of Forest Natural Resources)
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2 pages, 124 KiB  
Editorial
Pediatric Respiratory Viral Infection
by Stacy L. S. Yam, Joan Marie Javillo Baguio and Renee W. Y. Chan
Viruses 2024, 16(5), 733; https://doi.org/10.3390/v16050733 (registering DOI) - 06 May 2024
Abstract
Reflecting on this Special Issue dedicated to pediatric respiratory viruses, it is evident that the shadow cast by the global SARS-CoV-2 pandemic has profoundly impacted individuals of all ages and backgrounds, neonates and school-aged children being vulnerable cohorts resulting from the evolving immunological [...] Read more.
Reflecting on this Special Issue dedicated to pediatric respiratory viruses, it is evident that the shadow cast by the global SARS-CoV-2 pandemic has profoundly impacted individuals of all ages and backgrounds, neonates and school-aged children being vulnerable cohorts resulting from the evolving immunological profiles and limited exposures to immunity-building experienced during this unprecedented era [...] Full article
(This article belongs to the Special Issue Pediatric Respiratory Viral Infection)
18 pages, 6106 KiB  
Article
Numerical Modeling and Performance Evaluation of Carbon Fiber-Reinforced Polymer-Strengthened Concrete Culverts against Water-Induced Corrosion
by Hafiz Ahmed Waqas, Alireza Bahrami, Fayiz Amin, Mehran Sahil and Muhammad Saud Khan
Infrastructures 2024, 9(5), 82; https://doi.org/10.3390/infrastructures9050082 (registering DOI) - 06 May 2024
Abstract
Culverts fulfill the vital function of safely channeling water beneath railway tracks, highways, and overpasses. They serve various purposes, including facilitating drainage in areas such as watercourses, drainage zones, and regions with restricted ground-bearing capacity. Precast reinforced concrete (RC) box culverts are a [...] Read more.
Culverts fulfill the vital function of safely channeling water beneath railway tracks, highways, and overpasses. They serve various purposes, including facilitating drainage in areas such as watercourses, drainage zones, and regions with restricted ground-bearing capacity. Precast reinforced concrete (RC) box culverts are a popular choice because they are strong, durable, rigid, and economical. However, culverts are prone to corrosion due to exposure to a range of environmental factors and aggressive chemicals. Therefore, enhancing the design and construction of this crucial infrastructure is imperative to effectively combat corrosion and to adhere to modern standards of reliability and affordability. In this study, carbon fiber-reinforced polymer (CFRP) was used to strengthen corroded culverts, with promising potential to improve safety and longevity in these structures. This study compared the behavior of corroded RC box culverts to CFRP-strengthened ones using the finite element method (FEM). It explored the impact of varying the damage thicknesses owing to corrosion, ranging from 0 mm to 20 mm, on the structural performance of the box culverts. The results showed that the CFRP model exhibited a substantial 25% increase in the capacity and reduced the damage compared to the reference model. Moreover, a parametric study was conducted for establishing a cost-effective design, in which numerous CFRP strip configurations were examined for a damaged-culvert model. The results indicated that a complete CFRP sheet was most effective for the maximum design capacity and repair effectiveness. The study’s outcomes provide valuable insights for professionals engaged in enhancing the strength of box culverts, aiming to increase the capacity, enhance the stability, and strengthen corroded culverts. Full article
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