Histone deacetylases inhibitors (HDACis) have shown promising therapeutic outcomes in haematological malignancies such as leukaemia, multiple myeloma, and lymphoma, with disappointing results in solid tumours when used as monotherapy. As a result, combination therapies either with radiation or other deoxyribonucleic acid (DNA) damaging agents have been suggested as ideal strategy to improve their efficacy in solid tumours. Numerous in vitro and in vivo studies have demonstrated that HDACis can sensitise malignant cells to both electromagnetic and particle types of radiation by inhibiting DNA damage repair. Although the radiosensitising ability of HDACis has been reported as early as the 1990s, the mechanisms of radiosensitisation are yet to be fully understood. This review brings forth the various protocols used to sequence the administration of radiation and HDACi treatments in the different studies. The possible contribution of these various protocols to the ambiguity that surrounds the mechanisms of radiosensitisation is also highlighted. Full article

This cross-sectional study investigated the level of daytime sleepiness and sleep-related behaviors in preschool children and compared their self-evaluations with the evaluations of their parents. It was conducted in Split-Dalmatian County, Croatia, among 196 preschool children aged 6–7 years seen at regular medical examinations, accompanied by their parents, using the Epworth sleepiness scale for children and parents/caregivers. Compared to their child’s reports, parents tended to underestimate their child’s sleepiness while sitting in a classroom at school (p = 0.001) and overestimate their child’s sleepiness when lying down to rest or nap in the afternoon (p < 0.001). Boys were sleepier while sitting in a classroom at school during the morning than girls (p = 0.032). As much as 48.2% of preschool children had their own cellphones/tablets. Boys used video games (p < 0.001) and cellphones/tablets more than girls did (p = 0.064). Parental estimation of children playing video games at bedtime was lower than the child’s report (p < 0.001). Children who had a TV in their bedroom reported more daytime sleepiness (p = 0.049), and those who played video games at bedtime went to sleep later during the weekend (p = 0.024). Also, children owning cellphone/tablets had longer sleep latency during the weekend compared to children not owning a cellphone (p = 0.015). This study confirmed that parents tend to underestimate children’s habits of playing video games at bedtime and children’s sleepiness during morning classes. Preschool children who use electronic devices at bedtime more frequently have prolonged sleep latency. These findings provide further evidence of the effects of electronic media devices on preschoolers’ sleep patterns and daytime sleepiness. Full article

Alongside the capability to simulate rotor–stator interactions, a central aspect within the development of frequency-domain methods for turbomachinery flows is the ability of the method to accurately predict rotor–rotor and stator–stator interactions on a single-passage domain. To simulate such interactions, state-of-the-art frequency-domain approaches require one fundamental interblade phase angle, and therefore it can be necessary to resort to multi-passage configurations. Other approaches neglect the cross-coupling of different harmonics. As a consequence, the influence of indexing on the propagation of the unsteady disturbances is not captured. To overcome these issues, the harmonic balance approach based on multidimensional Fourier transforms in time, recently introduced by the authors, is extended in this work to account for arbitrary interblade phase angle ratios on a single-passage domain. To assess the ability of the approach to simulate the influence of indexing on the steady, as well as on the unsteady, part of the flow, the proposed extension is applied to a modern low-pressure fan stage of a civil aero engine under the influence of an inhomogeneous inflow condition. The results are compared to unsteady simulations in the time-domain and to state-of-the-art frequency-domain methods based on one-dimensional discrete Fourier transforms. Full article

Unmanned ground vehicles (UGVs) have gained increased attention in different fields of application; therefore, their optimization requires special attention. Lowering the mass of a UGV is especially important to increase its autonomy, agility, and payload capacity and to reduce dynamic forces. This contribution deals with optimizing a UGV unit prototype that, when connected with similar units, forms a moving electric fence for animal grazing. Together, these units form a robotic system that is intended to solve the critical problem of lack of human capacity in herding and grazing. This approach employs topology optimization (TO) and finite element analysis (FEA) to lower the mass of a UGV unit and validate the design of its structural components. To our knowledge, no optimization of this type of UGV has been reported in the literature. Here, we present the results of a case study in which a set of four load cases served as a basis for the optimization of the UGV frame. Response surface analysis (RSA) was used to identify the worst load cases, while substructuring was used to allow for more detailed meshing of the frame portion that was subjected to TO. Thereby, we demonstrate that the prototype of the UGV unit can be built using standard parts and that TO and FEA can be efficiently used to optimize the load-carrying structure of such a specific vehicle. Full article

In order to reduce carbon emissions, which are currently a problem in the shipping and offshore plant sectors, the international community is strengthening regulations such as the Energy Efficiency Design Index (EEDI) and Energy Efficiency Existing Ship Index (EEXI). To cope with this, eco-friendly fuel propulsion technology is being developed, and the development of an ammonia fuel supply system is in progress. Among them, fuel valve train (FVT) technology was researched for the final supply and cutoff of fuel and purging through nitrogen for ammonia engines. In this paper, we analyzed the change in ammonia supply due to FVT opening and the change in nitrogen supply due to closure. In addition, a plan to minimize risk factors was presented by applying a control method to remove residual fuel in FVT. According to the presented FVT model, the difference in the flow rate of supplied fuel was as much as 17.8 kg/s. Additionally, by opening the gas bleed valve at intervals during the closing process and purging about 0.28 kg of nitrogen, the internal fuel could be completely discharged. This is expected to have an impact on improving the marine environment through the application of eco-friendly fuels and the development of fuel supply system technology. Full article

Polyethylene glycol can abrogate plant seed dormancy and alleviate salt–alkali stress damage to plants, but its role in embryonic dormancy abrogation and germination in Sorbus pohuashanensis is not yet clear. The mechanism by which polyethylene glycol promotes the release of embryonic dormancy may be related to the synthesis and metabolism of endogenous hormones, reactive oxygen species and reactive nitrogen. In this article, germination in indoor culture dishes was used, and the most suitable conditions for treating S. pohuashanensis embryos, with polyethylene glycol (PEG) and sodium carbonate (Na₂CO₃), were selected. Germination was observed and recorded, and related physiological indicators such as endogenous hormones, reactive oxygen species and reactive nitrogen were measured and analyzed to elucidate the mechanism of polyethylene glycol in alleviating salt–alkali stress in S. pohuashanensis embryos. The results showed that soaking seeds in 5% PEG for 5 days is the best condition to promote germination, which can increase the germination rate of embryos under salt–alkali stress by 1–2 times and improve indicators such as germination speed and the germination index. Polyethylene glycol led to an increase in gibberellin (GA), indole-3-acetic acid (IAA), ethylene (ETH), cytokinin (CTK), nitric oxide (NO), soluble protein and soluble sugar in the embryos under salt–alkali stress; increased activities of superoxide dismutase (SOD), peroxidase (POD), catalase (CAT), nitrate reductase (NR) and nitric oxide synthase (NOS) in the embryos; a reduction in the accumulation of abscisic acid (ABA), hydrogen peroxide (H₂O₂) and malondialdehyde (MDA). Therefore, it is suggested that the inhibitory effect of polyethylene glycol on the salt–alkali-stress-induced germination of S. pohuashanensis embryos is closely related to the response of endogenous hormones, reactive oxygen species and nitric oxide signalling. Full article

Because climate change broadcasts a large aggregate risk to the overall macroeconomy and the global financial system, we investigate how a temperature anomaly and/or its volatility affect the accuracy of forecasts of stock return volatility. To this end, we do not apply only the classical GARCH and GARCHX models, but rather we apply newly proposed model-free prediction methods, and use GARCH-NoVaS and GARCHX-NoVaS models to compute volatility predictions. These two models are based on a normalizing and variance-stabilizing transformation (NoVaS transformation) and are guided by a so-called model-free prediction principle. Applying the new models to data for South Africa, we find that climate-related information is helpful in forecasting stock return volatility. Moreover, the novel model-free prediction method can incorporate such exogenous information better than the classical GARCH approach, as revealed by the the squared prediction errors. More importantly, the forecast comparison test reveals that the advantage of applying exogenous information related to climate risks in prediction of the South African stock return volatility is significant over a century of monthly data (February 1910–February 2023). Our findings have important implications for academics, investors, and policymakers. Full article

Caffeine has attracted significant attention from researchers in the sports field due to its well-documented ergogenic effects across various athletic disciplines. As research on caffeine continues to progress, there has been a growing emphasis on evaluating caffeine dosage and administration methods. However, investigations into the optimal timing of caffeine intake remain limited. Therefore, this narrative review aimed to assess the ergogenic effects of caffeine administration at different times during the morning (06:00 to 10:00) and evening (16:00 to 21:00). The review findings suggest that circadian rhythms play a substantial role in influencing sports performance, potentially contributing to a decline in morning performance. Caffeine administration has demonstrated effectiveness in mitigating this phenomenon, resulting in ergogenic effects and performance enhancement, even comparable to nighttime levels. While the specific mechanisms by which caffeine regulates circadian rhythms and influences sports performance remain unclear, this review also explores the mechanisms underlying caffeine’s ergogenic effects, including the adenosine receptor blockade, increased muscle calcium release, and modulation of catecholamines. Additionally, the narrative review underscores caffeine’s indirect impact on circadian rhythms by enhancing responsiveness to light-induced phase shifts. Although the precise mechanisms through which caffeine improves morning performance declines via circadian rhythm regulation necessitate further investigations, it is noteworthy that the timing of caffeine administration significantly affects its ergogenic effects during exercise. This emphasizes the importance of considering caffeine intake timing in future research endeavors to optimize its ergogenic potential and elucidate its mechanisms. Full article

The El Cielo Biosphere Reserve (CBR) stands as a vital forested region in eastern Mexico due to its high biodiversity in flora and fauna and provision of environmental services. This study established a network of 10 ring-width chronologies of different species within the CBR and adjacent watersheds. The objective was to analyze their climatic response and reconstruct the seasonal streamflow contribution of each sub-basin to the main stream, utilizing data from a gauge network of eight hydrological stations located at strategic locations of the CBR. With chronologies ranging from 116 to 564 years, most exhibited association with the accumulated streamflow between January and June. Based on the adjusted R², Akaike Information Criteria, and Variance Inflation Factor, the stepwise regression procedure was selected among different statistical methods for developing the reconstruction model. In spite of differences in the seasonal reconstructed periods, all the species showed potential to develop hydrological reconstructions as indicated by their common response to streamflow variability, as occurred in the wet years of 1976, 1993, 2000, and 2008, and dry years of 1980, 1982, 1996, and 2011. It was found that the response of the chronologies to gauge records increased as a function of the chronologies’ interseries correlation, average mean sensitivity, and distance of the tree-ring series to the gauge station. Streamflow reconstructions at the sub-basin level allowed a better understanding of the hydroclimatic variability characterizing the CBR, but also suggested the need to increase the network of chronologies for some particular sub-basins lacking tree-ring series to improve the reconstructed models. Full article

In this paper, experimental tensile tests for pre-cracked high Carbon steel ‘C90’ specimens were performed for quasi-static and dynamic loading. High loading velocity affects the crack patterns by preventing deflection. On the other hand, an efficient numerical tool based on the phase field model was developed and validated to predict brittle fracture trajectories. A staggered numerical scheme was adopted to solve the displacement and damage fields separately. Implementation efficiency in initiating and propagating cracks, even from an undamaged microstructure, was proved. The effect of the critical fracture energy density G_c on the crack path was tested; with smaller G_c, the crack patterns become more complex. In addition, the impact of loading velocities was examined, and earlier and faster crack formation and greater crack branching is observed with higher impact velocity. In this study, bidimensional plane stress cases were treated. The phase field model with hybrid formulation was able to predict crack pattern and especially crack arrest and branching found in the literature. The developed model accurately determined the transition zone of the crack path topology that has been observed experimentally. Full article

Low-carbon fly ash concrete is one of the hottest research topics in the concrete industry. This study proposes a design method for low-carbon fly ash concrete that systematically considers strength, form removal time, and carbonation durability life. The basic steps of this method are as follows: First, based on the experimental results, the strength development formula of fly ash concrete using different mix ratios and different aging periods is obtained through regression. The adopted carbonation depth calculation formula can be used to consider the influence of the curing time and mix ratio on carbonation depth. Second, through the analysis of design cases, the dominant factors in the design of low-carbon fly ash concrete are clarified. For example, strength dominates, demolding time dominates, or carbonation durability dominates. If the concrete is removed from the formwork early, the carbonation resistance is very weak, and a large amount of cementitious material is required in order to meet the carbonation durability requirements. Appropriately extending the removal time of the concrete form can enhance the carbonation durability, reduce the content of cementitious materials, and achieve the goal of low-carbon design. In short, the method proposed in this study can be used as a general method for low-carbon fly ash concrete design, and this method can be extended for use in different countries and regions. Full article

The majority of bearingless permanent magnet slice motors (BPMSMs) used in commercially available rotary blood pumps use a two-phase configuration, but it is unclear as to whether or not a comparable three-phase configuration would offer a better performance. This study compares the performance of two-phase and three-phase BPMSM configurations. Initially, two nominal designs were manufactured and empirically tested for their performance characteristics, namely, the axial stiffness, radial stiffness, and current force. Subsequently, finite element analysis (FEA) models were developed based on these nominal devices and validated against the empirical results. Simulations were then employed to assess the sensitivity of performance characteristics to variations in seven different geometric features of the models for both configurations. Our findings indicate that the nominal three-phase design had a higher axial stiffness and radial stiffness, but resulted in a lower axial-to-radial-stiffness ratio when compared to the nominal two-phase design. Additionally, while the nominal two-phase design shows a higher current force, the nominal three-phase design proves to be slightly superior when the force generated is considered relative to the power usage. Notably, the three-phase configuration demonstrates a greater sensitivity to dimensional changes in the geometric features. We observed that alterations in the air gap and rotor length lead to the most significant variations in performance characteristics. Although most changes in specific geometric features entail equal tradeoffs, increasing the head protrusion positively influences the overall performance. Moreover, we illustrated the interdependent nature of the head height and rotor height on the performance characteristics. Overall, this study delineates the strengths and weaknesses of each configuration, while also providing general insights into the relationship between specific geometric features and performance characteristics of BPMSMs. Full article

The rising demand for safe plant compounds and herbal products that contribute positively to human health is in line with current market trends. Plants belonging to the Satureja genus, particularly the aromatic medicinal S. montana L. from the Lamiaceae family, are well suited to these trends as they serve as pharmaceutical raw materials. This research aimed to assess the influence of sowing date and fertilization doses, as well as their interaction, on the fresh weight, essential oil content, and composition of S. montana. Experimental cultivation involved varying nitrogen and phosphorus levels. The second cut had the highest fresh weight and oil production compared to the first cut. The highest total plant biomass was achieved with autumn sowing and fertilization at 55 kg N/ha and 37 kg P/ha, whereas Spring sowing exhibited higher essential oil production, with the maximum oil % with 74 kg P/ha and oil yield after applying 55 kg N/ha and 74 kg P/ha. The GC-MS analysis revealed that carvacrol was the predominant compound, with it being recommended to grow S. montana in Spring at doses of 55 kg N/ha and 74 kg P/ha for the superior oil yield. Additionally, S. montana essential oil demonstrated notable biological and antimicrobial activity, positioning it as a potential alternative to chemical food preservatives. Full article

This paper studied the effect of the longitudinal magnetic field (LMF) on the microstructure evolution and mechanical properties of AZ40 argon tungsten arc welding joints. Magnetic field-assisted argon tungsten arc welding technology was used to achieve butt welding of an AZ40 Mg alloy sheet with a thickness of 1.5 mm. The microstructure of the Mg alloy weld was studied by using metallographic microscopy and scanning electron microscopy. Mechanical performance of the Mg alloy weld was evaluated by using a hardness tester and universal tensile machine. The experimental results revealed that the average crystallite dimension of the weld zone of the Mg alloy joint reached 43 μm without an LMF. By introducing LMF-assisted technology, the weld structure was significantly refined and the average crystallite dimension of the weld seam was reduced by 39.5% to 26 μm with a coil current of 1.2 A. For the joint without magnetic field assistance, the optimum tensile strength of the AZ40 weldment was 225 MPa under a welding current of 80 A, and fracture occurred in the center of joint welding seam. Under an LMF coil current of 1.2 A, the joint strength increased from the initial 225 MPa to 254 MPa, and fracture occurred at the weld edge with obvious plastic fracture characteristics. It can be confirmed that the LMF-assisted welding process effectively improved the microstructure characteristics of the weld seam and strengthened the microhardness and mechanical performance of the AZ40 joint. Full article

Prefabricated panel-assembled wall systems, comprising a confining frame and infill lightweight panels of autoclaved aerated concrete (AAC), are widely employed in framed structures. Different from studies on a main frame with infill walls, this study aimed to explore the seismic performance of partition walls, which were fabricated with AAC panel-assembled walls and located outside of the main frames. Two full-scale specimens, one with a door opening and the other without, were constructed and cyclic loading tests were executed to examine the failure modes, hysteresis characteristics, envelope curves, ductility, strength and stiffness degradation, as well as energy dissipation capacity of the AAC panel-assembled walls. Additionally, a restoring-force model for the panel-assembled walls was developed and a method for predicting the lateral load-bearing capacity of the AAC panel-assembled walls was proposed. The findings indicated that the panels enhanced the system’s lateral resistance, energy dissipation capacity, and deformation capability. The door frame increased the initial stiffness, peak lateral load and energy dissipation capacity of the AAC panel-assembled wall compared to the wall without a door frame. Compared to the specimen without a door frame, the peak lateral load of the specimen with a door frame increased by 19.7–30.1%. The deformation capacity of the panel-assembled walls aligned with the requirements for concrete framed structures. Full article

Oral mucositis (OM) occurs in more than 95% of patients irradiated in the head and neck area. This paper aims to determine the occurrence and characteristics of OM in patients with head and neck cancer (HNC), as well as the involvement of dentists/oral medicine specialists in treating such patients. Methods: This study was conducted at the Department of Otorhinolaryngology and Department of Oral Medicine, University Hospital Center Zagreb, from April to August 2022, on patients irradiated in the head and neck area. A unique OM questionnaire was created on the incidence, characteristics, oral care, and involvement of dentists in the overall care. Results: Thirty patients filled out the questionnaire. Of the 22 patients who had developed OM, 14 had grade-three OM. Ten patients were treated for OM in line with the instructions of an oral medicine specialist, eight based on the instructions of a specialist responsible for monitoring of the underlying disease, and four were not treated at all. Sixteen patients had not been referred to a dentist before the start of RT. Conclusions: These results showed insufficient care and treatment of OM, as well as insufficient involvement of dentists in the oncology team. Full article

A novel variable structure controller based on sliding mode is developed for addressing the trajectory tracking challenge encountered by wheeled mobile robots. Firstly, the trajectory tracking error model under the global coordinate system is established according to the kinematic model of the wheeled mobile robot. Secondly, the novel sliding mode algorithm and backstepping method are introduced to design the motion controller of the system, respectively. Different sliding mode surfaces are formulated to guarantee rapid and stable convergence of the system’s trajectory tracking error to zero. Ultimately, comparative simulation trials validate the controller’s ability to swiftly and consistently follow the reference trajectory. In contrast to traditional controllers, this controller shows rapid convergence, minimal error, and robustness. Full article

Adequate sodium and potassium intake, along with adherence to the Mediterranean diet (MedDiet), are key factors for preventing hypertension and cerebrovascular diseases. However, data on the consumption of these nutrients within the MedDiet are scarce. This cross-sectional study aims to assess the association between MedDiet adherence and sodium/potassium intake in the MIND-Matosinhos randomized controlled trial, targeting Portuguese adults at a high risk of dementia. Good adherence to the MedDiet was defined using the Portuguese Mediterranean Diet Adherence Screener questionnaire (≥10 points), and both sodium/potassium intakes were estimated from 24 hour urine collections. The association between MedDiet adherence and these nutrients’ intake (dichotomized by the median) was quantified by calculating odds ratios (OR) and respective 95% confidence intervals (95% CI) using a logistic regression. A total of 169 individuals (60.9% female; median age: 70 years; range: 36–85 years) were included. Good adherence to the MedDiet was observed among 18.3% of the sample. After adjusting for sex, age, education and using antihypertensive drugs, good MedDiet adherence was associated with higher sodium (OR = 3.11; 95% CI: 1.27–7.65) and potassium intake (OR = 9.74; 95% CI: 3.14–30.26). Increased adherence to the MedDiet may contribute to a higher potassium intake but seems to have limited effects on the adequacy of sodium levels. Full article

This study aims to establish common fixed point theorems for a pair of compatible self-mappings within the framework of extended parametric $S_b$-metric spaces. To support our assertions, we provide corollaries and examples accompanied with graphical representations. Moreover, we leverage our principal outcome to guarantee the existence of a common solution to a system of integral equations. Full article

The psychological refractory period (PRP) effect occurs when two stimuli that require separate responses are presented sequentially, particularly with a short and variable time interval between them. Fatigue is a suboptimal psycho-physiological state that leads to changes in strategies. In recent years, numerous studies have investigated the effects of transcranial direct current stimulation (tDCS) on motor control. The present study aimed to investigate the effects of two tDCS methods, anodal and cathodal, on PRP in ten different conditions of stimulus-onset asynchronies (SOAs) under non-fatigue and mental fatigue conditions. The participants involved 39 male university students aged 19 to 25 years. In the pre-test, they were assessed using the PRP measurement tool under both non-fatigue and mental fatigue conditions. The mental fatigue was induced by a 30-min Stroop task. The test consisted of two stimuli with different SOAs (50, 75, 100, 150, 300, 400, 600, 900, 1200, and 1500 ms). The first was a visual stimulus with three choices (letters A, B, and C). After a random SOA, the second stimulus, a visual stimulus with three choices (colors red, yellow, and blue), was presented. Subsequently, participants were randomly assigned to the anodal, cathodal, and sham stimulation groups and underwent four consecutive sessions of tDCS stimulation. In the anodal and cathodal stimulation groups, 20 min of tDCS stimulation were applied to the PLPFC area in each session, while in the sham group, the stimulation was artificially applied. All participants were assessed using the same measurement tools as in the pre-test phase, in a post-test phase one day after the last stimulation session, and in a follow-up phase four days after that. Inferential statistics include mixed ANOVA, one-way ANOVA, independent, and dependent t-tests. The findings indicated that the response time to the second stimulus was longer at lower SOAs. However, there was no significant difference between the groups in this regard. Additionally, there was no significant difference in response time to the second stimulus between the fatigue and non-fatigue conditions, or between the groups. Therefore, tDCS had no significant effect. There was a significant difference between mental fatigue and non-fatigue conditions in the psychological refractory period. Moreover, at lower SOAs, the PRP was longer than at higher SOAs. In conditions of fatigue, the active stimulation groups (anodal and cathodal) performed better than the sham stimulation group at higher SOAs. Considering the difference in response to both stimuli at different SOAs, some central aspects of the response can be simultaneously parallel. Fatigue also affects parallel processing. This study supports the response integration phenomenon in PRP, which predicts that there will be an increase in response time to the first stimulus as the interval between the presentation of the two stimuli increases. This finding contradicts the bottleneck model. In this study, the effectiveness of cathodal and anodal tDCS on response time to the second stimulus and PRP was found to be very small. Full article