The 2023 MDPI Annual Report has
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14 pages, 30993 KiB  
Article
Validating Synthetic Data for Perception in Autonomous Airport Navigation Tasks
by Miguel Ángel de Frutos Carro, Carlos Cerdán Villalonga and Antonio Barrientos Cruz
Aerospace 2024, 11(5), 383; https://doi.org/10.3390/aerospace11050383 (registering DOI) - 10 May 2024
Abstract
Autonomous navigation within airport environments presents significant challenges, mostly due to the scarcity of accessible and labeled data for training autonomous systems. This study introduces an innovative approach to assess the performance of vision-based models trained on synthetic datasets, with the goal of [...] Read more.
Autonomous navigation within airport environments presents significant challenges, mostly due to the scarcity of accessible and labeled data for training autonomous systems. This study introduces an innovative approach to assess the performance of vision-based models trained on synthetic datasets, with the goal of determining whether simulated data can train and validate navigation operations in complex airport environments. The methodology includes a comparative analysis employing image processing techniques and object detection algorithms. A comparative analysis of two different datasets was conducted: a synthetic dataset that mirrors real airport scenarios, generated using the Microsoft Flight Simulator 2020®video game, and a real-world dataset. The results indicate that models trained on a combination of both real and synthetic images perform much better in terms of adaptability and accuracy compared to those trained only on one type of dataset. This analysis makes a significant contribution to the field of autonomous airport navigation and offers a cost-effective and practical solution to overcome the challenges of dataset acquisition and algorithm validation. It is thus believed that this study lays the groundwork for future advancements in the field. Full article
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21 pages, 11898 KiB  
Article
Remote Sensing-Based Monitoring of Cotton Growth and Its Response to Meteorological Factors
by Sijia Yang, Renjun Wang, Jianghua Zheng, Wanqiang Han, Jiantao Lu, Pengyu Zhao, Xurui Mao and Hong Fan
Sustainability 2024, 16(10), 3992; https://doi.org/10.3390/su16103992 (registering DOI) - 10 May 2024
Abstract
Cotton is an important economic crop and strategic resource. Monitoring its growth and analysing its response to meteorological factors are crucial for field management and yield estimation. This study selects the primary cotton-producing regions in northern Xinjiang as the study area. Firstly, using [...] Read more.
Cotton is an important economic crop and strategic resource. Monitoring its growth and analysing its response to meteorological factors are crucial for field management and yield estimation. This study selects the primary cotton-producing regions in northern Xinjiang as the study area. Firstly, using the Google Earth Engine cloud platform, the Cotton Mapping Index (CMI) was utilised to extract cotton planting areas from 2019 to 2023. Secondly, Sentinel-2A data were used to calculate the NDVI of cotton during the growing season and analyse its variation characteristics. Finally, correlation, lag, and partial correlation analyses were conducted between cotton NDVI and meteorological factors, including effective accumulated temperature, wind speed, precipitation, and solar shortwave radiation, to explore the response relationship. The results indicate the following: (1) The optimal classification threshold of CMI in the study area was determined to be 0.74, which was applied to extract cotton planting areas over the years. The overall classification accuracy achieved was 84.85%. The R2 value for the cotton area extracted by CMI compared to the cotton planting area in the statistical yearbook data is 0.98, with an average relative error of 16.84%. CMI’s classification use effectively distinguishes cotton from other major crops, such as wheat and corn, in the study area. Compared with different classification methods, CMI is more convenient and efficient for extracting cotton planting areas, contributing significantly to yield estimation and management. (2) We found that from 2019 to 2023, some fields were planted with cotton yearly. In order to prevent land degradation, a crop rotation system should be implemented, in which cotton rotates with other crops to reduce the rate of soil nutrient loss and achieve sustainable agricultural development. (3) NDVI can effectively monitor the spatiotemporal changes and regional variations in cotton growth. Sentinel-2 multi-spectral imagery possesses high spatial and temporal resolution, enabling effective monitoring of cotton growth, provision of cotton growth data for field managers, and application in cotton production management. Additionally, cotton yield estimation can be achieved by comparing the overall growth of cotton across different years. (4) Cotton NDVI exhibits a strong correlation with effective accumulated temperature and solar radiation, with the majority passing the significance test, suggesting a significant promotion effect on cotton growth by accumulated temperature and solar radiation. In cotton cultivation management, attention should be directed toward monitoring changes in accumulated temperature and solar radiation. Moreover, NDVI changes in response to solar radiation exhibit a certain lag. The correlation between NDVI and precipitation is low, likely attributed to local cotton cultivation primarily relying on drip irrigation. Cotton NDVI is negatively correlated with wind speed. Cotton planting should consider weather changes and take corresponding preventive management measures. The research results have significant reference value for monitoring cotton growth, disaster prevention, and sustainable agricultural development. Full article
(This article belongs to the Special Issue Agriculture, Land and Farm Management)
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18 pages, 683 KiB  
Article
Outdoor-to-Indoor mmWave Relaying with Massive MIMO: Impact of Imperfect Channel Estimation
by Nawal Bounouader, Houda Chafnaji and Mustapha Benjillali
Electronics 2024, 13(10), 1857; https://doi.org/10.3390/electronics13101857 (registering DOI) - 10 May 2024
Abstract
Assuming incomplete knowledge of the channel state information (CSI), we investigate two scenarios involving millimeter wave (mmWave) relaying to support outdoor-to-indoor communications. We proceed to derive the average signal-to-noise ratio (SNR) expressions for two relaying scenarios and quantify the asymptotic SNR. The performance [...] Read more.
Assuming incomplete knowledge of the channel state information (CSI), we investigate two scenarios involving millimeter wave (mmWave) relaying to support outdoor-to-indoor communications. We proceed to derive the average signal-to-noise ratio (SNR) expressions for two relaying scenarios and quantify the asymptotic SNR. The performance of the two relaying scenarios is evaluated using the outage probability—for which we have derived closed-form equations—the end-to-end channel capacity, and the energy efficiency. The obtained results are compared with those derived assuming complete knowledge of the CSI. The effect of the imperfect CSI is therefore assessed in relation to the reference of perfect CSI. In these scenarios, an outside base station (BS) in an urban cellular network serves several indoor users. In the context of a two-hop full-duplex (FD) relaying scheme, we initially suggest a method in which the base station (BS) utilizes zero-forcing (ZF) precoding, and we take into account the overall channel response. Furthermore, we make the assumption that the base station (BS) engages in precoding only depending on the response of the channel in the first hop; in this second design, the relay precodes (using the response of the second-hop channel), amplifies, and sends the signals. Both techniques utilize massive multiple-input–multiple-output (mMIMO) arrays to permit transmission. We also present Monte Carlo simulation results to assess the accuracy of our analytical results. Finally, the two systems are compared in terms of channel estimation and precoding complexity, the number of antennas, as well as the number of users. Practical deployment recommendations are formulated at the end of this work. Full article
(This article belongs to the Special Issue New Trends and Methods in Communication Systems: Volume II)
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23 pages, 1220 KiB  
Article
Arguments for a Community-Based Approach to Geothermal Energy Development
by Katarzyna A. Kurek, Johan van Ophem and Jacek Strojny
Energies 2024, 17(10), 2299; https://doi.org/10.3390/en17102299 (registering DOI) - 10 May 2024
Abstract
This paper investigates the theoretical foundation for developing renewable geothermal resources locally. For this reason, we pay attention to the role of communities in geothermal development. We derive it from the integral characteristics of geothermal energy next to the shift in the energy [...] Read more.
This paper investigates the theoretical foundation for developing renewable geothermal resources locally. For this reason, we pay attention to the role of communities in geothermal development. We derive it from the integral characteristics of geothermal energy next to the shift in the energy transition policies to focus on managing green resources locally. This study presents arguments for a framework that approaches geothermal resources as an endogenous factor of community development. To analyse it, we create a model that explains the local economic characteristics of geothermal exploitation beyond its geological conditions. It aims to conceptualise a community-based geothermal development standard referring to the endogeneity principle. Geothermal energy is given attention since the characteristics of this resource determine its use locally. This induces the internalisation of labour and technology in the local economic system, a specific condition for local geothermal projects where a community remains a prime beneficiary. We argue that the role of communities in geothermal exploitation is pivotal in the process of green growth for further expansion of geothermal energy use. Full article
(This article belongs to the Section C: Energy Economics and Policy)
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32 pages, 4863 KiB  
Article
From Eye Movements to Personality Traits: A Machine Learning Approach in Blood Donation Advertising
by Stefanos Balaskas, Maria Koutroumani, Maria Rigou and Spiros Sirmakessis
AI 2024, 5(2), 635-666; https://doi.org/10.3390/ai5020034 (registering DOI) - 10 May 2024
Abstract
Blood donation heavily depends on voluntary involvement, but the problem of motivating and retaining potential blood donors remains. Understanding the personality traits of donors can assist in this case, bridging communication gaps and increasing participation and retention. To this end, an eye-tracking experiment [...] Read more.
Blood donation heavily depends on voluntary involvement, but the problem of motivating and retaining potential blood donors remains. Understanding the personality traits of donors can assist in this case, bridging communication gaps and increasing participation and retention. To this end, an eye-tracking experiment was designed to examine the viewing behavior of 75 participants as they viewed various blood donation-related advertisements. The purpose of these stimuli was to elicit various types of emotions (positive/negative) and message framings (altruistic/egoistic) to investigate cognitive reactions that arise from donating blood using eye-tracking parameters such as the fixation duration, fixation count, saccade duration, and saccade amplitude. The results indicated significant differences among the eye-tracking metrics, suggesting that visual engagement varies considerably in response to different types of advertisements. The fixation duration also revealed substantial differences in emotions, logo types, and emotional arousal, suggesting that the nature of stimuli can affect how viewers disperse their attention. The saccade amplitude and saccade duration were also affected by the message framings, thus indicating their relevance to eye movement behavior. Generalised linear models (GLMs) showed significant influences of personality trait effects on eye-tracking metrics, including a negative association between honesty–humility and fixation duration and a positive link between openness and both the saccade duration and fixation count. These results indicate that personality traits can significantly impact visual attention processes. The present study broadens the current research frontier by employing machine learning techniques on the collected eye-tracking data to identify personality traits that can influence donation decisions and experiences. Participants’ eye movements were analysed to categorize their dominant personality traits using hierarchical clustering, while machine learning algorithms, including Support Vector Machine (SVM), Random Forest, and k-Nearest Neighbours (KNN), were employed to predict personality traits. Among the models, SVM and KNN exhibited high accuracy (86.67%), while Random Forest scored considerably lower (66.67%). This investigation reveals that computational models can infer personality traits from eye movements, which shows great potential for psychological profiling and human–computer interaction. This study integrates psychology research and machine learning, paving the way for further studies on personality assessment by eye tracking. Full article
(This article belongs to the Special Issue Machine Learning for HCI: Cases, Trends and Challenges)
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15 pages, 831 KiB  
Article
Transcriptome Analysis of Sake Yeast in Co-Culture with kuratsuki Kocuria
by Karin Kobayashi and Hiromi Nishida
Fermentation 2024, 10(5), 249; https://doi.org/10.3390/fermentation10050249 (registering DOI) - 10 May 2024
Abstract
Kuratsuki bacteria enter the sake production process and affect the flavor and taste of sake. This study compared gene expression in the sake yeast Saccharomyces cerevisiae in co-culture with kuratsuki Kocuria to that in monoculture. Among the 5922 genes of S. cerevisiae, [...] Read more.
Kuratsuki bacteria enter the sake production process and affect the flavor and taste of sake. This study compared gene expression in the sake yeast Saccharomyces cerevisiae in co-culture with kuratsuki Kocuria to that in monoculture. Among the 5922 genes of S. cerevisiae, 71 genes were upregulated more than 2-fold, and 61 genes were downregulated less than 0.5-fold in co-culture with kuratsuki Kocuria. Among the stress-induced genes, fourteen were upregulated, and six were downregulated. Among the fourteen upregulated genes, six were induced in response to replication stress. Although the G1 cyclin gene CLN3 was upregulated by more than 2-fold, eight genes that were induced in response to meiosis and/or sporulation were also upregulated. Fourteen metabolism-related genes, for example, the glyceraldehyde-3-phosphate dehydrogenase genes TDH1, TDH2, and TDH3, were downregulated by less than 0.5-fold in co-culture with kuratsuki Kocuria. The gene expression patterns of S. cerevisiae co-cultured with kuratsuki Kocuria differed from those co-cultured with lactic acid bacteria. Therefore, S. cerevisiae responded differently to different bacterial species. This strongly suggests that kuratsuki bacteria affect gene expression in sake yeast, thereby affecting the flavor and taste of sake. Full article
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11 pages, 4194 KiB  
Article
Influence of Biofilm Maturity on the Antibacterial Efficacy of Cold Atmospheric Plasma in Oral Microcosm Biofilms
by Hee-Eun Kim
Biomedicines 2024, 12(5), 1056; https://doi.org/10.3390/biomedicines12051056 (registering DOI) - 10 May 2024
Abstract
As biofilms mature, biomass and extracellular polysaccharide (EPS) content increases, enhancing pathogenicity. Therefore, this study aimed to evaluate the antibacterial efficacy of cold atmospheric plasma (CAP) against oral microcosm biofilms and the influence of biofilm maturity on treatment. Oral microcosm biofilms were cultured [...] Read more.
As biofilms mature, biomass and extracellular polysaccharide (EPS) content increases, enhancing pathogenicity. Therefore, this study aimed to evaluate the antibacterial efficacy of cold atmospheric plasma (CAP) against oral microcosm biofilms and the influence of biofilm maturity on treatment. Oral microcosm biofilms were cultured on hydroxyapatite disks for 2 and 6 days. Based on the treatment and biofilm maturity, these were subsequently allocated into six groups (N = 19 each): Groups 1 and 2 were incubated with distilled water for 1 min; Groups 3 and 4 were treated with CAP for 2 min, and Groups 5 and 6 were treated with 0.12% chlorhexidine gluconate for 1 min. Groups 1, 3, and 5 represent 2-day biofilms, and Groups 2, 4, and 6 represent 6-day biofilms. Treatments were repeated daily for 5 days. Antibacterial efficacy was analyzed by measuring oral biofilms’ red fluorescence intensity (RatioR/G) and quantifying EPS content and bacterial viability. The RatioR/G was 1.089-fold and 1.104-fold higher in Groups 4 and 6 than in Groups 3 and 5 following antibacterial treatment, respectively (p < 0.001). EPS content increased by 1.71-fold in Group 6 than in Group 5 (p < 0.001). Bacterial survival rate was the lowest in Group 3 (p = 0.005). These findings underscore the relevance of CAP treatment in maintaining antibacterial efficacy regardless of the biofilm development stage, highlighting its potential utility in oral care. Full article
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23 pages, 1466 KiB  
Review
Synthetic Degradable Polyvinyl Alcohol Polymer and Its Blends with Starch and Cellulose—A Comprehensive Overview
by Abdallah S. Elgharbawy, Abdel-Ghaffar M. El Demerdash, Wagih A. Sadik, Mosaad A. Kasaby, Ahmed H. Lotfy and Ahmed I. Osman
Polymers 2024, 16(10), 1356; https://doi.org/10.3390/polym16101356 (registering DOI) - 10 May 2024
Abstract
Approximately 50% of global plastic wastes are produced from plastic packaging, a substantial amount of which is disposed of within a few minutes of its use. Although many plastic types are designed for single use, they are not always disposable. It is now [...] Read more.
Approximately 50% of global plastic wastes are produced from plastic packaging, a substantial amount of which is disposed of within a few minutes of its use. Although many plastic types are designed for single use, they are not always disposable. It is now widely acknowledged that the production and disposal of plastics have led to a plethora of negative consequences, including the contamination of both groundwater and soil resources and the deterioration of human health. The undeniable impact of excessive plastic manufacturing and waste generation on the global plastic pollution crisis has been well documented. Therefore, degradable polymers are a crucial solution to the problem of the non-degradation of plastic wastes. The disadvantage of degradable polymers is their high cost, so blending them with natural polymers will reduce the cost of final products and maximize their degradation rate, making degradable polymers competitive with industrial polymers that are currently in use daily. In this work, we will delineate various degradable polymers, including polycaprolactone, starch, and cellulose. Furthermore, we will elucidate several aspects of polyvinyl alcohol (PVA) and its blends with natural polymers to show the effects of adding natural polymers on PVA properties. This paper will study cost-effective and ecologically acceptable polymers by combining inexpensive natural polymers with readily accessible biodegradable polymers such as polyvinyl alcohol (PVA). Full article
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9 pages, 2765 KiB  
Case Report
A Difficult Case of Ventriculitis in a 40-Year-Old Woman with Acute Myeloid Leukemia
by Raffaella Rubino, Marcello Trizzino, Luca Pipitò, Giuseppe Sucato, Marco Santoro, Rosario Maugeri, Domenico Gerardo Iacopino, Giovanni Maurizio Giammanco, Sergio Siragusa and Antonio Cascio
Antibiotics 2024, 13(5), 432; https://doi.org/10.3390/antibiotics13050432 (registering DOI) - 10 May 2024
Abstract
Ventriculitis and nosocomial meningitis caused by carbapenem-resistant Gram-negative and vancomycin-resistant Gram-positive bacteria represent a growing treatment challenge. A case of ventriculitis and bacteremia caused by carbapenem-resistant, KPC-producing Klebsiella pneumoniae and vancomycin-resistant Enterococcus faecium in a young woman with acute leukemia who was successfully [...] Read more.
Ventriculitis and nosocomial meningitis caused by carbapenem-resistant Gram-negative and vancomycin-resistant Gram-positive bacteria represent a growing treatment challenge. A case of ventriculitis and bacteremia caused by carbapenem-resistant, KPC-producing Klebsiella pneumoniae and vancomycin-resistant Enterococcus faecium in a young woman with acute leukemia who was successfully treated with meropenem/vaborbactam (MVB), rifampicin, and linezolid is described in this paper. This case report emphasizes the importance of a multidisciplinary strategy, including infectious focus control, for the treatment of device-associated central nervous system (CNS) infections from multidrug-resistant bacteria. Considering the novel resistance patterns, more research on drug penetration into the central nervous system, as well as on the necessity of association therapies, is needed. Full article
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15 pages, 9466 KiB  
Article
Study of Nanohydroxyapatite Coatings Prepared by the Electrophoretic Deposition Method at Various Voltage and Time Parameters
by Klaudia Malisz, Beata Świeczko-Żurek, Jean-Marc Olive, Grzegorz Gajowiec, Gilles Pecastaings, Aleksandra Laska and Alina Sionkowska
Materials 2024, 17(10), 2242; https://doi.org/10.3390/ma17102242 (registering DOI) - 10 May 2024
Abstract
The aim of the work is to compare the properties of nanohydroxyapatite coatings obtained using the electrophoretic deposition method (EDP) at 10 V, 20 V, and 30 V, and with deposit times of 2 and 5 min. The primary sedimentation was used to [...] Read more.
The aim of the work is to compare the properties of nanohydroxyapatite coatings obtained using the electrophoretic deposition method (EDP) at 10 V, 20 V, and 30 V, and with deposit times of 2 and 5 min. The primary sedimentation was used to minimize the risk of the formation of particle agglomerates on the sample surface. Evaluation of the coating was performed by using a Scanning Electron Microscope (SEM), Energy-Dispersive Spectroscopy (EDS), Atomic Force Microscopy (AFM), optical profilometer, drop shape analyzer, and a nanoscratch tester. All of the coatings are homogeneous without any agglomerates. When low voltage (10 V) was used, the coatings were uniform and continuous regardless of the deposition time. The increase in voltage resulted in the formation of cracks in the coatings. The wettability test shows the hydrophilic behavior of the coatings and the mean contact angle values are in the range of 20–37°. The coatings showed excellent adhesion to the substrate. The application of a maximum force of 400 mN did not cause delamination in most coatings. It is concluded that the optimal coating for orthopedic implants (such as hip joint implants, knee joint implants or facial elements) is obtained at 10 V and 5 min because of its homogeneity, and a contact angle that promotes osseointegration and great adhesion to the substrate. Full article
(This article belongs to the Special Issue Advances in Metal Coatings for Wear and Corrosion Applications)
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17 pages, 1774 KiB  
Article
Ecological Requirements for Abundance and Dispersion of Brazilian Yellow Fever Vectors in Tropical Areas
by Amanda Francisco Prado, Paula Ribeiro Prist, Luis Filipe Mucci and Patrícia Domingues de Freitas
Int. J. Environ. Res. Public Health 2024, 21(5), 609; https://doi.org/10.3390/ijerph21050609 (registering DOI) - 10 May 2024
Abstract
In the Americas, wild yellow fever (WYF) is an infectious disease that is highly lethal for some non-human primate species and non-vaccinated people. Specifically, in the Brazilian Atlantic Forest, Haemagogus leucocelaenus and Haemagogus janthinomys mosquitoes act as the major vectors. Despite transmission risk [...] Read more.
In the Americas, wild yellow fever (WYF) is an infectious disease that is highly lethal for some non-human primate species and non-vaccinated people. Specifically, in the Brazilian Atlantic Forest, Haemagogus leucocelaenus and Haemagogus janthinomys mosquitoes act as the major vectors. Despite transmission risk being related to vector densities, little is known about how landscape structure affects vector abundance and movement. To fill these gaps, we used vector abundance data and a model-selection approach to assess how landscape structure affects vector abundance, aiming to identify connecting elements for virus dispersion in the state of São Paulo, Brazil. Our findings show that Hg. leucocelaenus and Hg. janthinomys abundances, in highly degraded and fragmented landscapes, are mainly affected by increases in forest cover at scales of 2.0 and 2.5 km, respectively. Fragmented landscapes provide ecological corridors for vector dispersion, which, along with high vector abundance, promotes the creation of risk areas for WYF virus spread, especially along the border with Minas Gerais state, the upper edges of the Serra do Mar, in the Serra da Cantareira, and in areas of the metropolitan regions of São Paulo and Campinas. Full article
(This article belongs to the Section Environmental Health)
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25 pages, 12688 KiB  
Article
Gait Impairment Analysis Using Silhouette Sinogram Signals and Assisted Knowledge Learning
by Mohammed A. Al-masni, Eman N. Marzban, Abobakr Khalil Al-Shamiri, Mugahed A. Al-antari, Maali Ibrahim Alabdulhafith, Noha F. Mahmoud, Nagwan Abdel Samee and Yasser M. Kadah
Bioengineering 2024, 11(5), 477; https://doi.org/10.3390/bioengineering11050477 (registering DOI) - 10 May 2024
Abstract
The analysis of body motion is a valuable tool in the assessment and diagnosis of gait impairments, particularly those related to neurological disorders. In this study, we propose a novel automated system leveraging artificial intelligence for efficiently analyzing gait impairment from video-recorded images. [...] Read more.
The analysis of body motion is a valuable tool in the assessment and diagnosis of gait impairments, particularly those related to neurological disorders. In this study, we propose a novel automated system leveraging artificial intelligence for efficiently analyzing gait impairment from video-recorded images. The proposed methodology encompasses three key aspects. First, we generate a novel one-dimensional representation of each silhouette image, termed a silhouette sinogram, by computing the distance and angle between the centroid and each detected boundary points. This process enables us to effectively utilize relative variations in motion at different angles to detect gait patterns. Second, a one-dimensional convolutional neural network (1D CNN) model is developed and trained by incorporating the consecutive silhouette sinogram signals of silhouette frames to capture spatiotemporal information via assisted knowledge learning. This process allows the network to capture a broader context and temporal dependencies within the gait cycle, enabling a more accurate diagnosis of gait abnormalities. This study conducts training and an evaluation utilizing the publicly accessible INIT GAIT database. Finally, two evaluation schemes are employed: one leveraging individual silhouette frames and the other operating at the subject level, utilizing a majority voting technique. The outcomes of the proposed method showed superior enhancements in gait impairment recognition, with overall F1-scores of 100%, 90.62%, and 77.32% when evaluated based on sinogram signals, and 100%, 100%, and 83.33% when evaluated based on the subject level, for cases involving two, four, and six gait abnormalities, respectively. In conclusion, by comparing the observed locomotor function to a conventional gait pattern often seen in healthy individuals, the recommended approach allows for a quantitative and non-invasive evaluation of locomotion. Full article
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15 pages, 2588 KiB  
Article
Novel Tick-Borne Anaplasmataceae Genotypes in Tropical Birds from the Brazilian Pantanal Wetland
by Amir Salvador Alabí Córdova, Alan Fecchio, Ana Cláudia Calchi, Clara Morato Dias, Anna Claudia Baumel Mongruel, Lorena Freitas das Neves, Daniel Antonio Braga Lee, Rosangela Zacarias Machado and Marcos Rogério André
Microorganisms 2024, 12(5), 962; https://doi.org/10.3390/microorganisms12050962 (registering DOI) - 10 May 2024
Abstract
Despite numerous reports of Anaplasmataceae agents in mammals worldwide, few studies have investigated their occurrence in birds. The present study aimed to investigate the occurrence and molecular identity of Anaplasmataceae agents in birds from the Pantanal wetland, Brazil. Blood samples were collected from [...] Read more.
Despite numerous reports of Anaplasmataceae agents in mammals worldwide, few studies have investigated their occurrence in birds. The present study aimed to investigate the occurrence and molecular identity of Anaplasmataceae agents in birds from the Pantanal wetland, Brazil. Blood samples were collected from 93 different species. After DNA extraction, samples positive for the avian β-actin gene were subjected to both a multiplex quantitative real-time (q)PCR for Anaplasma and Ehrlichia targeting the groEL gene and to a conventional PCR for Anaplasmataceae agents targeting the 16S rRNA gene. As a result, 37 (7.4%) birds were positive for Anaplasma spp. and 4 (0.8%) for Ehrlichia spp. in the qPCR assay; additionally, 13 (2.6%) were positive for Anaplasmataceae agents in the PCR targeting the 16S rRNA gene. The Ehrlichia 16S rRNA sequences detected in Arundinicola leucocephala, Ramphocelus carbo, and Elaenia albiceps were positioned closely to Ehrlichia sp. Magellanica. Ehrlichia dsb sequences detected in Agelasticus cyanopus and Basileuterus flaveolus grouped with Ehrlichia minasensis. The 16S rRNA genotypes detected in Crax fasciolata, Pitangus sulphuratus and Furnarius leucopus grouped with Candidatus Allocryptoplasma. The 23S-5S genotypes detected in C. fasciolata, Basileuterus flaveolus, and Saltator coerulescens were related to Anaplasma phagocytophilum. In conclusion, novel genotypes of Anaplasma, Ehrlichia, and Candidatus Allocryptoplasma were detected in birds from the Pantanal wetland. Full article
(This article belongs to the Section Parasitology)
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17 pages, 2359 KiB  
Review
LDH-Based Voltammetric Sensors
by Domenica Tonelli, Matteo Tonelli, Stefano Gianvittorio and Andreas Lesch
Micromachines 2024, 15(5), 640; https://doi.org/10.3390/mi15050640 (registering DOI) - 10 May 2024
Abstract
Layered double hydroxides (LDHs), also named hydrotalcite-like compounds, are anionic clays with a lamellar structure which have been extensively used in the last two decades as electrode modifiers for the design of electrochemical sensors. These materials can be classified into LDHs containing or [...] Read more.
Layered double hydroxides (LDHs), also named hydrotalcite-like compounds, are anionic clays with a lamellar structure which have been extensively used in the last two decades as electrode modifiers for the design of electrochemical sensors. These materials can be classified into LDHs containing or not containing redox-active centers. In the former case, a transition metal cation undergoing a reversible redox reaction within a proper potential window is present in the layers, and, therefore, it can act as electron transfer mediator, and electrocatalyze the oxidation of an analyte for which the required overpotential is too high. In the latter case, a negatively charged species acting as a redox mediator can be introduced into the interlayer spaces after exchanging the anion coming from the synthesis, and, again, the material can display electrocatalytic properties. Alternatively, due to the large specific surface area of LDHs, molecules with electroactivity can be adsorbed on their surface. In this review, the most significant electroanalytical applications of LDHs as electrode modifiers for the development of voltammetric sensors are presented, grouping them based on the two types of materials. Full article
(This article belongs to the Special Issue Advances in Voltammetric Sensors)
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15 pages, 890 KiB  
Article
Is CYP2C Haplotype Relevant for Efficacy and Bleeding Risk in Clopidogrel-Treated Patients?
by Lana Ganoci, Jozefina Palić, Vladimir Trkulja, Katarina Starčević, Livija Šimičević, Nada Božina, Martina Lovrić-Benčić, Zdravka Poljaković and Tamara Božina
Genes 2024, 15(5), 607; https://doi.org/10.3390/genes15050607 (registering DOI) - 10 May 2024
Abstract
A recently discovered haplotype—CYP2C:TG—determines the ultrarapid metabolism of several CYP2C19 substrates. The platelet inhibitor clopidogrel requires CYP2C19-mediated activation: the risk of ischemic events is increased in patients with a poor (PM) or intermediate (IM) CYP2C19 metabolizer phenotype (vs. normal, NM; rapid, [...] Read more.
A recently discovered haplotype—CYP2C:TG—determines the ultrarapid metabolism of several CYP2C19 substrates. The platelet inhibitor clopidogrel requires CYP2C19-mediated activation: the risk of ischemic events is increased in patients with a poor (PM) or intermediate (IM) CYP2C19 metabolizer phenotype (vs. normal, NM; rapid, RM; or ultrarapid, UM). We investigated whether the CYP2C:TG haplotype affected efficacy/bleeding risk in clopidogrel-treated patients. Adults (n = 283) treated with clopidogrel over 3–6 months were classified by CYP2C19 phenotype based on the CYP2C19*2*17 genotype, and based on the CYP2C19/CYP2C cluster genotype, and regarding carriage of the CYP2:TG haplotype, and were balanced on a number of covariates across the levels of phenotypes/haplotype carriage. Overall, 45 (15.9%) patients experienced ischemic events, and 49 (17.3%) experienced bleedings. By either classification, the incidence of ischemic events was similarly numerically higher in PM/IM patients (21.6%, 21.8%, respectively) than in mutually similar NM, RM, and UM patients (13.2–14.8%), whereas the incidence of bleeding events was numerically lower (13.1% vs. 16.6–20.5%). The incidence of ischemic events was similar in CYP2C:TG carries and non-carries (14.1% vs. 16.1%), whereas the incidence of bleedings appeared mildly lower in the former (14.9% vs. 20.1%). We observed no signal to suggest a major effect of the CYP2C19/CYP2C cluster genotype or CYP2C:TG haplotype on the clinical efficacy/safety of clopidogrel. Full article
(This article belongs to the Section Pharmacogenetics)
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15 pages, 4685 KiB  
Article
Optimal Control for an Epidemic Model of COVID-19 with Time-Varying Parameters
by Yiheng Li
Mathematics 2024, 12(10), 1484; https://doi.org/10.3390/math12101484 (registering DOI) - 10 May 2024
Abstract
The coronavirus disease 2019 (COVID-19) pandemic disrupted public health and economies worldwide. In this paper, we investigate an optimal control problem to simultaneously minimize the epidemic size and control costs associated with intervention strategies based on official data. Considering people with undetected infections, [...] Read more.
The coronavirus disease 2019 (COVID-19) pandemic disrupted public health and economies worldwide. In this paper, we investigate an optimal control problem to simultaneously minimize the epidemic size and control costs associated with intervention strategies based on official data. Considering people with undetected infections, we establish a control system of COVID-19 with time-varying parameters. To estimate these parameters, a parameter identification scheme is adopted and a mixed algorithm is constructed. Moreover, we present an optimal control problem with two objectives that involve the newly increased number of infected individuals and the control costs. A numerical scheme is conducted, simulating the epidemic data pertaining to Shanghai during the period of 2022, caused by the Omicron variant. Coefficient combinations of the objectives are obtained, and the optimal control measures for different infection peaks are indicated. The numerical results suggest that the identification variables obtained by using the constructed mixed algorithm to solve the parameter identification problem are feasible. Optimal control measures for different epidemic peaks can serve as references for decision-makers. Full article
(This article belongs to the Topic Mathematical Modeling)
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19 pages, 16965 KiB  
Review
Application of Digital Twin in Electric Vehicle Powertrain: A Review
by Xiaokang Li, Wenxu Niu and Haobin Tian
World Electr. Veh. J. 2024, 15(5), 208; https://doi.org/10.3390/wevj15050208 (registering DOI) - 10 May 2024
Abstract
Digital Twin (DT) is widely regarded as a highly promising technology with the potential to revolutionize various industries, making it a key trend in the Industry 4.0 era. In a cost-effective and risk-free setting, digital twins facilitate the interaction and merging of the [...] Read more.
Digital Twin (DT) is widely regarded as a highly promising technology with the potential to revolutionize various industries, making it a key trend in the Industry 4.0 era. In a cost-effective and risk-free setting, digital twins facilitate the interaction and merging of the physical and informational realms. The application of digital twins spans across different sectors, including aerospace, healthcare, smart manufacturing, and smart cities. As electric vehicles have experienced rapid growth, there is a growing demand for the development of innovative technologies. One potential area for digital twins application is within the automotive sector. The powertrain system of electric vehicles (EVs) consists of three parts, power source, power electronic system, and electric motor, which are considered as the core components of electric vehicles. The focus of this paper is to conduct a methodical review regarding the use of digital twins in the powertrain of electric vehicles (EVs). While reviewing the development of digital twin technology, its main application scenarios and its use in electric vehicle powertrains are analysed. Finally, the digital twins currently encounter several challenges that need to be addressed, and so the future development of their application to electric vehicles are summarized. Full article
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13 pages, 313 KiB  
Article
The Association of Longer Breastfeeding Duration and Socioeconomic, Pregnancy, Childbirth and Postpartum Characteristics
by Jekaterina Kozachenko, Anda Kivite-Urtane, Frederika Berzina, Ieva Evelina Stolcere and Gunta Lazdane
Medicina 2024, 60(5), 792; https://doi.org/10.3390/medicina60050792 (registering DOI) - 10 May 2024
Abstract
Background and Objectives: Breastmilk is the safest and most suitable food for an infant, playing the role of their first vaccine and containing all the essential nutrients for the first months of life. The World Health Organisation recommends exclusive breastfeeding for the first [...] Read more.
Background and Objectives: Breastmilk is the safest and most suitable food for an infant, playing the role of their first vaccine and containing all the essential nutrients for the first months of life. The World Health Organisation recommends exclusive breastfeeding for the first 6 months of life and continued breastfeeding while introducing a child to complementary foods until 2 years and beyond. According to Latvian statistics from 2022, only 27.4% of babies were breastfed for 12 months. The aim of this study was to determine the socio-economic factors and factors related to pregnancy, childbirth and postpartum that influence breastfeeding for more than 6 months in Latvia. Materials and Methods: Data were used from the cross-sectional survey “Research on factors and behaviours affecting the sexual and reproductive health of the population of Latvia”, which was conducted in 2023. A study sample was randomised and stratified by gender and five age groups. The analyses in this study are based on a sample of women who had given birth at least once (n = 1407), and the dependent variable was the duration of breastfeeding their last child. Binary logistic regression was conducted to identify the associated factors. Results: The point prevalence of longer duration of breastfeeding for the last child was 47.9% (n = 674). The odds of longer breastfeeding duration were higher among mothers who did not smoke during pregnancy (vs. smokers, aOR 2.1, p < 0.001), of Latvian nationality (vs. Russian, aOR 1.3, p = 0.03), who had two childbirth (vs. one, aOR 1.5, p = 0.003), who had the highest level of education (vs. primary education, aOR 2.0, p = 0.03), started breastfeeding immediately after the birth (vs. later than the first day, aOR 1.7, p = 0.01) or on the first day (vs. later, aOR 1.6, p = 0.01). Conclusions: We documented socio-demographic pregnancy and childbirth factors associated with longer breastfeeding durations. Efforts to promote breastfeeding practices should target mothers from the most vulnerable groups. Full article
(This article belongs to the Section Obstetrics and Gynecology)
13 pages, 925 KiB  
Review
BIA-ALCL and BIA-SCC: Updates on Clinical Features and Genetic Mutations for Latest Recommendations
by Gennaro D’Orsi, Martina Giacalone, Alessio Calicchia, Elettra Gagliano, Lisa Vannucchi, Gianluca Vanni, Oreste Claudio Buonomo, Valerio Cervelli and Benedetto Longo
Medicina 2024, 60(5), 793; https://doi.org/10.3390/medicina60050793 (registering DOI) - 10 May 2024
Abstract
Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) and Breast Implant-Associated Squamous Cell Carcinoma (BIA-SCC) are emerging neoplastic complications related to breast implants. While BIA-ALCL is often linked to macrotextured implants, current evidence does not suggest an implant-type association for BIA-SCC. Chronic inflammation and [...] Read more.
Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) and Breast Implant-Associated Squamous Cell Carcinoma (BIA-SCC) are emerging neoplastic complications related to breast implants. While BIA-ALCL is often linked to macrotextured implants, current evidence does not suggest an implant-type association for BIA-SCC. Chronic inflammation and genetics have been hypothesized as key pathogenetic players, although for both conditions, the exact mechanisms and specific risks related to breast implants are yet to be established. While the genetic alterations in BIA-SCC are still unknown, JAK-STAT pathway activation has been outlined as a dominant signature of BIA-ALCL. Recent genetic investigation has uncovered various molecular players, including MEK-ERK, PI3K/AKT, CDK4-6, and PDL1. The clinical presentation of BIA-ALCL and BIA-SCC overlaps, including most commonly late seroma and breast swelling, warranting ultrasound and cytological examinations, which are the first recommended steps as part of the diagnostic work-up. While the role of mammography is still limited, MRI and CT-PET are recommended according to the clinical presentation and for disease staging. To date, the mainstay of treatment for BIA-ALCL and BIA-SCC is implant removal with en-bloc capsulectomy. Chemotherapy and radiation therapy have also been used for advanced-stage BIA-ALCL and BIA-SCC. In-depth characterization of the tumor genetics is key for the development of novel therapeutic strategies, especially for advanced stage BIA-ALCL and BIA-SCC, which show a more aggressive course and poor prognosis. Full article
(This article belongs to the Special Issue Updates on Post-mastectomy Breast Reconstruction)
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15 pages, 338 KiB  
Article
An Autoethnography on Intergenerational Relationships and Transnational Care for Older Parents
by Weiguo Zhang
Genealogy 2024, 8(2), 56; https://doi.org/10.3390/genealogy8020056 (registering DOI) - 10 May 2024
Abstract
I employ autoethnography to undertake a broader scholarly inquiry on intergenerational relationships and transnational care shaped by global migration and aging. Specifically, I reflect on the dynamics of my relationship with my mother, beginning with my departure from my home and spanning a [...] Read more.
I employ autoethnography to undertake a broader scholarly inquiry on intergenerational relationships and transnational care shaped by global migration and aging. Specifically, I reflect on the dynamics of my relationship with my mother, beginning with my departure from my home and spanning a period of 40 years, 8 in China and 34 outside China. In doing so, I contemplate theoretical models of intergenerational solidarity, ambivalence, and role ambiguity. I also challenge cultural assumptions of filial piety. The geographical distance, passage of time, and acculturation process have profoundly influenced my perception of filial piety, which differs markedly from my mother’s. However, this divergence in consensual solidarity—marked by variations in attitudes, beliefs, and values—does not translate into weakened affectual solidarity, characterized by positive sentiments and emotions. Furthermore, aided by advancements in transportation and social media technology, I have been able to extend crucial emotional and some “instrumental” care to my mother, along with financial support if needed, despite limited hands-on care. Nevertheless, I must negotiate my care for my mother and navigate a delicate balance in coordinating my care efforts with those of my non-migrant siblings. Full article
(This article belongs to the Special Issue Challenges in Multicultural Marriages and Families)
14 pages, 3636 KiB  
Article
Influence of Physical–Mechanical Strength and Water Absorption Capacity on Sawdust–Waste Paper–Recycled Plastic Hybrid Composite for Ceiling Tile Application
by Berhanu Tolessa Amena and Nazia Hossain
J. Compos. Sci. 2024, 8(5), 176; https://doi.org/10.3390/jcs8050176 (registering DOI) - 10 May 2024
Abstract
In recent times, there has been a notable surge in the interest in promoting environmentally conscious products, particularly within the building industry where the focus has shifted towards sustainable materials. In this study, as a sustainable building material, ceiling tiles have been fabricated [...] Read more.
In recent times, there has been a notable surge in the interest in promoting environmentally conscious products, particularly within the building industry where the focus has shifted towards sustainable materials. In this study, as a sustainable building material, ceiling tiles have been fabricated as a composite board containing waste materials, namely waste paper, sawdust, recycled polyethylene terephthalate (PET), and epoxy resin, and characterized comprehensively through physical and mechanical tests, density, thickness swelling (TS), modulus of elasticity (MOE), modulus of rupture (MOR), and flexural strength (FS) for product stability. A total of nine composites were fabricated with different ratios through molding techniques, and the characterization results were compared to determine the optimized stable ratio of composite composition. The composition of 25% waste paper, 15% sawdust, 10% recycled PET, and 50% epoxy resin presented the maximum FS compared to the other composite ratios. Water absorption (WA) and thickness swelling were evaluated after immersion durations of 1–24 h. The findings revealed that as the density increased, the sawdust content within the matrix decreased from 25–35%. Concurrently, an increase in recycled PET content resulted in decreased water absorption and thickness swelling. Significantly, the MOE, MOR, and FS demonstrated optimal values at 864.256 N/mm2, 12.786 N/mm2, and 4.64 MPa, respectively. These observations represent the excellent qualities of this hybrid composite board, particularly in terms of sustainability, stability, and water absorption capacity. Moreover, its lightweight nature and ability to support ceiling loads further enhance its appeal for construction applications. This study not only advances the discourse on sustainable construction materials but also fosters opportunities for broader acceptance and innovation within the industry. Full article
(This article belongs to the Special Issue Recycled Polymer Composites: Futuristic Sustainable Material)
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15 pages, 1892 KiB  
Article
Graph Analysis of the Visual Cortical Network during Naturalistic Movie Viewing Reveals Increased Integration and Decreased Segregation Following Mild TBI
by Tatiana Ruiz, Shael Brown and Reza Farivar
Vision 2024, 8(2), 33; https://doi.org/10.3390/vision8020033 (registering DOI) - 10 May 2024
Abstract
Traditional neuroimaging methods have identified alterations in brain activity patterns following mild traumatic brain injury (mTBI), particularly during rest, complex tasks, and normal vision. However, studies using graph theory to examine brain network changes in mTBI have produced varied results, influenced by the [...] Read more.
Traditional neuroimaging methods have identified alterations in brain activity patterns following mild traumatic brain injury (mTBI), particularly during rest, complex tasks, and normal vision. However, studies using graph theory to examine brain network changes in mTBI have produced varied results, influenced by the specific networks and task demands analyzed. In our study, we employed functional MRI to observe 17 mTBI patients and 54 healthy individuals as they viewed a simple, non-narrative underwater film, simulating everyday visual tasks. This approach revealed significant mTBI-related changes in network connectivity, efficiency, and organization. Specifically, the mTBI group exhibited higher overall connectivity and local network specialization, suggesting enhanced information integration without overwhelming the brain’s processing capabilities. Conversely, these patients showed reduced network segregation, indicating a less compartmentalized brain function compared to healthy controls. These patterns were consistent across various visual cortex subnetworks, except in primary visual areas. Our findings highlight the potential of using naturalistic stimuli in graph-based neuroimaging to understand brain network alterations in mTBI and possibly other conditions affecting brain integration. Full article
(This article belongs to the Section Visual Neuroscience)
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17 pages, 2084 KiB  
Article
Methane Production Reduced by Lignin Derivatives in Pulping Wastewater: Inhibition of Free Hydrolase
by Jinxun Lei, Zhihong Xu, Yong Chen, Guo Yu, Zexiang Liu, Shuangfei Wang, Jian Zhang, Kelin Li and Li Xie
Fermentation 2024, 10(5), 247; https://doi.org/10.3390/fermentation10050247 (registering DOI) - 10 May 2024
Abstract
The lignin derivatives generated during pulping might be responsible for the suboptimal performance of anaerobic reactors during the treatment of pulping wastewater. However, the exact mechanisms by which these derivatives exert influence remain unclear. This study investigated the influence of lignin derivatives, simulated [...] Read more.
The lignin derivatives generated during pulping might be responsible for the suboptimal performance of anaerobic reactors during the treatment of pulping wastewater. However, the exact mechanisms by which these derivatives exert influence remain unclear. This study investigated the influence of lignin derivatives, simulated using humic acids (HAs), in anaerobic granular sludge (AnGS). Compared to the enzymes present during floc-bonding and granule-bonding, the HAs impeded the conversion of unhydrolyzed substrates into methane and caused considerable inactivation of free enzymes. Simultaneously, the HAs suppressed agglomeration and weakened the strength of the AnGS. Furthermore, calcium ions helped maintain the integrity of the sludge structure. Therefore, the inhibition of extracellular enzymes using lignin derivatives delays the methanation of unhydrolyzed substrates, resulting in a reduced biomass within AnGS reactors owing to sludge disintegration and biomass loss. This study serves as a reference for investigating the persistent risks originating from lignin derivatives associated with using anaerobic granular-sludge bed reactors to treat pulping wastewater. Full article
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