South Asians (SAs) have a higher risk of developing type 2 diabetes (T2D) than white Europeans, especially following gestational diabetes mellitus (GDM). Despite similar blood glucose levels post-GDM, SAs exhibit more insulin resistance (IR) than Nordics, though the underlying mechanisms are unclear. This study aimed to assess markers of adipose tissue (AT) IR and liver fat in SA and Nordic women post-GDM. A total of 179 SA and 108 Nordic women in Norway underwent oral glucose tolerance tests 1–3 years post-GDM. We measured metabolic markers and calculated the AT IR index and non-alcoholic fatty liver disease liver fat (NAFLD-LFS) scores. Results showed that normoglycaemic SAs had less non-esterified fatty acid (NEFA) suppression during the test, resembling prediabetes/T2D responses, and higher levels of plasma fetuin-A, CRP, and IL-6 but lower adiponectin, indicating AT inflammation. Furthermore, normoglycaemic SAs had higher NAFLD-LFS scores, lower insulin clearance, and higher peripheral insulin than Nordics, indicating increased AT IR, inflammation, and liver fat in SAs. Higher liver fat markers significantly contributed to the ethnic disparities in glucose metabolism, suggesting a key area for intervention to reduce T2D risk post-GDM in SAs. Full article

High-dynamic-range integrated magnetometers demonstrate extensive potential applications in fields involving complex and changing magnetic fields. Among them, Diamond Nitrogen Vacancy Color Core Magnetometer has outstanding performance in wide-range and high-precision magnetic field measurement based on its inherent high spatial resolution, high sensitivity and other characteristics. Therefore, an innovative frequency-tracking scheme is proposed in this study, which continuously monitors the resonant frequency shift of the NV color center induced by a time-varying magnetic field and feeds it back to the microwave source. This scheme successfully expands the dynamic range to 6.4 mT, approximately 34 times the intrinsic dynamic range of the diamond nitrogen-vacancy (NV) center. Additionally, it achieves efficient detection of rapidly changing magnetic field signals at a rate of 0.038 T/s. Full article

The specific damping capacity variation of heat-treated NiTi was observed during a pseudoelasticity test. The detailed B2 → R-phase transformation process in cold-drawn NiTi wires undergoing middle-temperature aging was studied via X-ray diffraction, transmission electron microscope, and internal friction technique. Results show that, as aging time increased at 450 °C, the dynamic phase transition splitting from B2 → R to B2 → R₁ and B2 → R₂ became evident. However, such a splitting process was not observed for the sample after aging at 400 °C. The reason for R-phase generation is attributed to non-uniformly distributed stress fields. The splitting of the internal friction peak, in conjunction with high-resolution transmission electron microscope and mechanic results, suggests a substantial occurrence of short-range segregation of Ni atoms in the B2-NiTi matrix. Furthermore, the specific damping capacity (SDC) exhibits a gradual increase with prolonged annealing time. Specifically, the sample with significant dynamic phase transition splitting reaches an SDC value of 0.60. Full article

Surface-enhanced Raman scattering (SERS) is a promising technique for sensitive detection. The design and optimization of plasma-enhanced structures for SERS applications is an interesting challenge. In this study, we found that the SERS activity of MXene (Ti₃C₂T_x) can be improved by adding Au nanoparticles (NPs) in a simple photoreduction process. Fluoride-salt-etched MXene was deposited by drop-casting on a glass slide, and Au NPs were formed by the photocatalytic growth of gold(III) chloride trihydrate solutions under ultraviolet (UV) irradiation. The Au–MXene substrate formed by Au NPs anchored on the Ti₃C₂T_x sheet produced significant SERS through the synergistic effect of chemical and electromagnetic mechanisms. The structure and size of the Au-decorated MXene depended on the reaction time. When the MXene films were irradiated with a large number of UV photons, the size of the Au NPs increased. Hot spots were formed in the nanoscale gaps between the Au NPs, and the abundant surface functional groups of the MXene effectively adsorbed and interacted with the probe molecules. Simultaneously, as a SERS substrate, the proposed Au–MXene composite exhibited a wider linear range of 10⁻⁴–10⁻⁹ mol/L for detecting carbendazim. In addition, the enhancement factor of the optimized SERS substrate Au–MXene was 1.39 × 10⁶, and its relative standard deviation was less than 13%. This study provides a new concept for extending experimental strategies to further improve the performance of SERS. Full article

Recently, nanomaterials have attracted extensive attention in cancer-targeting therapy and as drug delivery vehicles owing to their unique surface and size properties. Multifunctional combinations of nanomaterials have become a research hotspot as researchers aim to provide a full understanding of their nanomaterial characteristics. In this study, metal–organic framework-capped gold nanorod hybrids were synthesized. Our research explored their ability to kill tumor cells by locally increasing the temperature via photothermal conclusion. The specific peroxidase-like activity endows the hybrids with the ability to disrupt the oxidative balance in vitro. Simultaneously, chemotherapeutic drugs are administered and delivered by loading and transportation for effective combinatorial cancer treatment, thereby enhancing the curative effect and reducing the unpredictable toxicity and side effects of large doses of chemotherapeutic drugs. These studies can improve combinatorial cancer therapy and enhance cancer treatment. Full article

Fracture network fracturing is pivotal for achieving the economical and efficient development of shale gas, with the connectivity among fracture networks playing a crucial role in reservoir stimulation effectiveness. However, flow back data that reflect fracture network connectivity information are often ignored, resulting in an inaccurate prediction of the effective fracture network volume (EFNV). The accurate calculation of the EFNV has become a key and difficult issue in the field of shale fracturing. For this reason, the accurate shale gas effective fracture network volume inversion method needs to be improved. Based on the flow back characteristics of fracturing fluids, a tree-shaped fractal fracture flow back mathematical model for inversion of EFNV was established and combined with fractal theory. A genetic algorithm workflow suitable for EFNV inversion of shale gas was constructed based on the flow back data after fracturing, and the fracture wells in southern Sichuan were used as an example to carry out the EFNV inversion. The reliability of the inversion model was verified by testing production, cumulative gas production, and microseismic results. The field application showed that the inversion method proposed in this paper can obtain tree-shaped fractal fracture network structure parameters, fracture system original pressure, matrix gas breakthrough pressure, fracture compressibility coefficient, reverse imbibition index, equivalent main fracture half length, and effective initial fracture volume (EIFV). The calculated results of the model belong to the same order of magnitude as those of the HD model and Alkouh model, and the model has stronger applicability. This research has important theoretical guiding significance and field application value for improving the accuracy of the EFNV calculation. Full article

Hyperventilation induces metabolic changes that can elicit nystagmus (hyperventilation-induced nystagmus, HVIN) in various vestibular disorders, revealing vestibular imbalance and bringing out central or peripheral asymmetries. In acute unilateral vestibulopathy (AUVP, namely vestibular neuritis), hyperventilation can induce different patterns of nystagmus (excitatory, inhibitory, or negative), disclosing or modifying existing static vestibular asymmetries through its ability to invalidate compensation or increase peripheral excitability. In this context, we followed the evolutionary stages of HVIN in AUVP across 35 consecutive patients, with the goal of assessing alterations in the oculomotor pattern caused by hyperventilation over time. In the acute phase, the incidence of the excitatory pattern (and the strongly excitatory one, consisting of a reversal nystagmus evoked by hyperventilation) was significantly higher compared to the inhibitory pattern; then, a progressive reduction in the incidence of the excitatory pattern and a concomitant gradual increase in the incidence of the inhibitory one were observed in the follow-up period. Assuming the role of the ephaptic effect and the transient loss of vestibular compensation as opposing mechanisms, i.e., excitatory and inhibitory, respectively, the oculomotor pattern evoked by hyperventilation is the result of the interaction of these two factors. The data obtained allowed us to hypothesize an interpretative model regarding the pathogenetic aspects of responses evoked by hyperventilation and the etiologies of the disease: according to our hypotheses, the excitatory pattern implies a neuritic (viral) form of AUVP; instead, the inhibitory (and negative) one can be an expression of both the neuritic (viral) and vascular forms of the disease. Full article

Chickpeas hold significant nutritional and cultural importance, being a rich source of protein, fiber, and essential vitamins and minerals. They are a staple ingredient in various cuisines worldwide. Peeling chickpeas is considered a crucial pre-consumption operation due to the undesirability of peels for some uses. This study aimed to design, test, and evaluate a small chickpea seed peeling machine. The peeling prototype was designed in accordance with the chickpeas’ measured properties; the seeds’ moisture content was determined to be 6.96% (d.b.). The prototype was examined under four different levels of drum revolving speeds (100, 200, 300, and 400 rpm), and three different numbers of brush peeling rows. The prototype was tested with rotors of four, eight, and twelve rows of brushes. The evaluation of the chickpea peeling machine encompassed several parameters, including the machine’s throughput (kg/h), energy consumption (kW), broken seeds percentage (%), unpeeled seeds percentage (%), and peeling efficiency (%). The obtained results revealed that the peeling machine throughput (kg/h) exhibited an upward trend with increases in the rotation speed of the peeling drum. Meanwhile, the throughput decreased as the number of peeling brushes installed on the roller increased. The highest recorded productivity of 71.29 kg/h was achieved under the operational condition of 400 rpm and four peeling brush rows. At the same time, the peeling efficiency increased with the increase in both of peeling drum rotational speed and number of peeling brush rows. The highest peeling efficiency (97.2%) was recorded at the rotational speed of 400 rpm and twelve peeling brush rows. On the other hand, the lowest peeling efficiency (92.85%) was recorded at the lowest drum rotational speed (100 rpm) and number of peeling brush rows (4 rows). In the optimal operational condition, the machines achieved a throughput of 71.29 kg/h, resulting in a peeling cost of 0.001 USD per kilogram. This small-scale chickpea peeling machine is a suitable selection for small and medium producers. Full article

An irrigation quality assessment for rural Hyderabad was made by determining the pH, EC, TDS and TH beside major cations and anions. This study employed various parameters to determine the suitability of groundwater for irrigation and its hydrochemistry. Permissible limits of major cations and anions revealed that approximately 26% of samples exceeded acceptable levels for Electrical Conductivity (EC), 87% for Ca²⁺, 89% for Mg²⁺, and 60% for Na⁺, while none exceeded the limits for K⁺. Conversely, 47% of samples for HCO₃⁻, 91% for Cl⁻, and 100% for SO₄²⁻, NO₃⁻, and CO₃²⁻ proved suitability for irrigation. Notably, irrigation indices highlighted favorable results, with 100% conformity for SAR, SSP, RSP, and PI values, and substantial percentages of 78% and 85% for MH and KR values, respectively, affirming their suitability for irrigation practices. Employing the USSL diagram, 22%, 65%, and 11% of samples fall into the C2S1, C3S1, and C4S1 categories. According to the Wilcox diagram, 25%, 43%, 30%, and 2% are classified under C1, C2, C3, and C4 categories, respectively. The Gibbs ratio shows a concentration within the evaporation dominance, and CAI values showed positive ion exchange. Overall, Hyderabad’s rural areas are generally suitable for irrigation, apart from certain areas where water quality may not be acceptable for plants lacking high salt tolerance. Full article

Nephron sparing surgery (NSS) is considered for selected cases of upper tract urothelial carcinoma (UTUC) as it maintains renal function and avoids morbidity associated with radical nephroureterectomy (RNU). The appropriate selection of patients suitable for NSS without compromising oncological outcomes can sometimes be difficult, given the limitations of diagnostic modalities. Recurrence rates for UTUC can be as high as 36 to 54% after NSS. Intraluminal adjuvant therapy can be attempted following NSS to reduce recurrence, but delivery to the upper tract is more challenging than into the bladder. Bacillus Calmette-Guerin (BCG) and chemotherapy such as Mitomycin (MMC) have been administered via nephrostomy or ureteric catheter, which requires invasive/repeated instrumentation of the upper urinary tract. Drug delivery by reflux from bladder instillation along indwelling stents has also been tried but can potentially be unreliable. Recently, a gel formulation of mitomycin has been developed for the controlled exposure of the upper urinary tract to treatment over a number of hours. Drug-eluting stents to deliver chemotherapy to the upper urinary tract have been developed but have not yet entered clinical practice. Endoluminal phototherapy utilising an intravenous photosensitising agent is another novel approach that has recently been described. Intraluminal therapies may be beneficial in decreasing recurrence rates in UTUC, but currently have some limitations in their usage. Full article

Multimodal deception detection has received increasing attention from the scientific community in recent years, mainly due to growing ethical and security issues, as well as the growing use of digital media. A great number of deception detection methods have been proposed in several domains, such as political elections, security contexts, and job interviews. However, a systematic analysis of the current situation and the evaluation and future directions of deception detection based on cues coming from multiple modalities seems to be lacking. This paper, starting from a description of methods and metrics used for the analysis and evaluation of multimodal deception detection on video, provides a vision of future directions in this field. For the analysis, the PRISMA recommendations are followed, which allow the collection and synthesis of all the available research on the topic and the extraction of information on the multimodal features, the fusion methods, the classification approaches, the evaluation datasets, and metrics. The results of this analysis contribute to the assessment of the state of the art and the evaluation of evidence on important research questions in multimodal deceptive deception. Moreover, they provide guidance on future research in the field. Full article

Renewable energy-based compact energy-generation systems based on the organic Rankine cycle (ORC) can be employed to meet the ever-growing thirst for affordable and clean energy. The overall performance and effectiveness of ORC systems are constrained by the low efficiency of the gas expander, specifically the positive displacement expander, which is responsible for energy conversion from the working fluid. This low-efficiency scenario can be significantly improved by employing a control valve to regulate and restrict the flow of the working fluid into the expander. A control valve can effectively curve the loss of costly compressed and energized working fluids by allowing them to expand in the expander chamber before discharging through the outlet port. They can thus be used to regulate the amount of energy yield and output power. In this work, two direct drive rotary valves (DDRVs) operated by a stepper motor (SM-DDRV) and rotary solenoid (RS-DDRV) are suggested, and the behavior of the valves is examined. The effect of friction and temperature on the valve response is also studied. Additionally, the effect of inlet control valves on the overall system performance of the limaçon expander is assessed. Thermodynamic properties such as the isentropic efficiency and filling factor are also computed. The effect of leakage due to valve response delay is analyzed at different inlet pressures. The performance indices are compared to the expander performance without any inlet valve. The SM-DDRV setup results in a 14.86% increase in isentropic efficiency and a 220% increase in the filling factor, whereas the RS-DDRV performs moderately with a 2.58% increase in isentropic efficiency and an 80% increase in the filling factor compared to a ported expander. The SM-DDRV provides better performance indices compared to the RS-DDRV and without valve setups. However, the performance of the limaçon expander with the SM-DDRV is sensitive to the inlet pressure and degrades at higher pressure. Overall, the valves proposed in this work present key insights into improving the performance characteristics of gas expanders of ORC systems. Full article

Object detection is one of the core technologies for autonomous driving. Current road object detection mainly relies on visible light, which is prone to missed detections and false alarms in rainy, night-time, and foggy scenes. Multispectral object detection based on the fusion of RGB and infrared images can effectively address the challenges of complex and changing road scenes, improving the detection performance of current algorithms in complex scenarios. However, previous multispectral detection algorithms suffer from issues such as poor fusion of dual-mode information, poor detection performance for multi-scale objects, and inadequate utilization of semantic information. To address these challenges and enhance the detection performance in complex road scenes, this paper proposes a novel multispectral object detection algorithm called MRD-YOLO. In MRD-YOLO, we utilize interaction-based feature extraction to effectively fuse information and introduce the BIC-Fusion module with attention guidance to fuse different modal information. We also incorporate the SAConv module to improve the model’s detection performance for multi-scale objects and utilize the AIFI structure to enhance the utilization of semantic information. Finally, we conduct experiments on two major public datasets, FLIR_Aligned and M³FD. The experimental results demonstrate that compared to other algorithms, the proposed algorithm achieves superior detection performance in complex road scenes. Full article

Enhanced screening protocols for cancer detection have increased survival in patients with head and neck cancer (HNC), which highlights the need to address the sequelae of therapy-induced cardiovascular complications. This study was conducted to assess the incidence and risk of acute myocardial infarction (AMI) in patients with HNC who have not undergone radiation or chemotherapy using a comprehensive, population-based cohort dataset. A total of 2976 individuals without cancer and 744 individuals with HNC were matched using the propensity score method. The findings indicated that the occurrence rates of AMI were comparable between the HNC (2.19) and non-cancer groups (2.39). Cox regression analysis did not demonstrate a significant increase in the risk of AMI in patients with HNC (hazard ratio: 0.93, 95% confidence interval: 0.50–1.73). No increased risk of AMI was observed in the HNC group compared to the non-cancer group, regardless of the time since the HNC diagnosis. Subgroup analyses showed no notable differences in the AMI risk between the groups when considering sex, age, comorbidities, and cancer type. This study showed that patients with HNC who have not been treated with radiation or chemotherapy did not exhibit an increased incidence or risk of AMI compared to individuals without cancer. Full article

In response to potential denial environments such as canyons, gullies, islands, and cities where users are located, traditional Telemetry, Tracking, and Command (TT&C) systems can still maintain core requirements such as availability, reliability, and sustainability in the face of complex electromagnetic environments and non-line-of-sight environments that may cause service degradation or even failure. This paper presents a single-station emergency solution that integrates communication and TT&C (IC&T) functions based on radar chaff cloud technology. Firstly, a suitable selection of frequency bands and modulation methods is provided for the emergency IC&T system to ensure compatibility with existing communication and TT&C systems while catering to the future needs of IC&T. Subsequently, theoretical analyses are conducted on the communication link transmission loss, data transmission, code tracking accuracy, and anti-multipath model of the emergency IC&T system based on the chosen frequency band and modulation mode. This paper proposes a dual-way asynchronous precision ranging and time synchronization (DWAPR&TS) system employing dual one-way ranging (DOWR) measurement, a dual-way asynchronous incoherent Doppler velocity measurement (DWAIDVM) system, and a single baseline angle measurement system. Next, we analyze the physical characteristics of the radar chaff and establish a dynamic model of spherical chaff cloud clusters based on free diffusion. Additionally, we provide the optimal strategy for deploying chaff cloud. Finally, the emergency IC&T application based on the radar chaff cloud relay is simulated, and the results show that for severe interference, taking drones as an example, under a measurement baseline of 100 km, the emergency IC&T solution proposed in this paper can achieve an accuracy range of approximately 100 m, a velocity accuracy of 0.1 m/s, and an angle accuracy of 0.1°. In comparison with existing TT&C system solutions, the proposed system possesses unique and potential advantages that the others do not have. It can serve as an emergency IC&T reference solution in denial environments, offering significant value for both civilian and military applications. Full article

Postconcussion syndrome (PCS) is one of the leading complications that may appear in patients after mild head trauma. Every day, thousands of people, regardless of age, gender, and race, are diagnosed in emergency departments due to head injuries. Traumatic Brain Injury (TBI) is a significant public health problem, impacting an estimated 1.5 million people in the United States and up to 69 million people worldwide each year, with 80% of these cases being mild. An analysis of the available research and a systematic review were conducted to search for a solution to predicting the occurrence of postconcussion syndrome. Particular biomarkers that can be examined upon admission to the emergency department after head injury were found as possible predictive factors of PCS development. Setting one unequivocal definition of PCS is still a challenge that causes inconsistent results. Neuron Specific Enolase (NSE), Glial Fibrillary Acidic Protein (GFAP), Ubiquitin C-terminal Hydrolase-L1 (UCH-L1), Serum Protein 100 B (s100B), and tau protein are found to be the best predictors of PCS development. The presence of all mentioned biomarkers is confirmed in severe TBI. All mentioned biomarkers are used as predictors of PCS. A combined examination of NSE, GFAP, UCH-1, S100B, and tau protein should be performed to detect mTBI and predict the development of PCS. Full article

This paper gives an overview over all currently available data sets for the European Long-term Ecosystem Research (eLTER) monitoring site Gesäuse-Johnsbachtal. The site is part of the LTSER platform Eisenwurzen in the Alps of the province of Styria, Austria. It contains both protected (National Park Gesäuse) and non-protected areas (Johnsbachtal). Although the main research focus of the eLTER monitoring site Gesäuse-Johnsbachtal is on inland surface running waters, forests and other wooded land, the eLTER whole system (WAILS) approach was followed in regard to the data selection, systematically screening all available data in regard to its suitability as eLTER’s Standard Observations (SOs). Thus, data from all system strata was included, incorporating Geosphere, Atmosphere, Hydrosphere, Biosphere and Sociosphere. In the WAILS approach these SOs are key data for a whole system approach towards long term ecosystem research. Altogether, 54 data sets have been collected for the eLTER monitoring site Gesäuse-Johnsbachtal and included in the Dynamical Ecological Information Management System – Site and Data Registry (DEIMS-SDR), which is the eLTER data platform. The presented work provides all these data sets through dedicated data repositories for FAIR use. This paper gives an overview on all compiled data sets and their main properties. Additionally, the available data are evaluated in a concluding gap analysis with regard to the needed observation data according to WAILS, followed by an outlook on how to fill these gaps. Full article

Underwater acoustic vector sensors (UAVSs) are increasingly utilized for remote passive sonar detection, but the accuracy of direction-of-arrival (DOA) estimation remains a challenging problem, particularly under low signal-to-noise ratio (SNR) conditions and complex background noise. In this paper, a comprehensive theoretical analysis is conducted on UAVS signal preprocessing subjected to gain-phase uncertainties for average acoustic intensity measurement (AAIM) and complex acoustic intensity measurement (CAIM)-based vector DOA estimation, aiming to explain the theoretical restrictions of intensity-based vector acoustic preprocessing approaches. On this basis, a generalized vector acoustic preprocessing optimization model is established in which the principle can be described as “maximizing the denoising performance under the constraints of an equivalent amplitude-gain response and phase-bias response”. A novel vector acoustic preprocessing method named linear matched stochastic resonance (LMSR) is proposed within the framework of matched stochastic resonance theory, which can naturally guarantee the linear gain-phase restrictions, as well achieving effective denoising performance. Numerical analyses demonstrate the superior vector DOA estimation performance of our proposed LMSR-AAIM and LMSR-CAIM methods in comparison to classical intensity-based AAIM and CAIM methods, especially under low-SNR conditions and non-Gaussian impulsive noise circumstances. Experimental verification conducted in the South China Sea further verifies its the effectiveness for practical application. This work can lay a solid foundation to break through the challenges of underwater remote vector acoustic DOA estimation under low-SNR conditions and complex ocean ambient noise and can provide important guidance for future research work. Full article

A gearbox compound fault intelligent diagnosis method based on the period group sparse model is proposed for the problem that the fault features are coupled with each other and the fault components are superimposed on each other and difficult to be separated in the gearbox compound fault signal. Firstly, a binary sequence is constructed to embed the fault pulse period as a priori knowledge into the group sparse model to decouple and separate the composite fault signal while maintaining the amplitude and sparsity of the extracted features. Secondly, the wavelet packet energy features of the decoupled signals are extracted to improve the data quality while enhancing the characterization ability of the dictionary in the classification model. Finally, the wavelet packet energy features are imported into the sparse dictionary classification model, and the fault diagnosis is completed by outputting the fault categories using the self-driven characteristics of the data. The results show that the fault identification accuracy using the proposed method is 97%. In addition, the experimental validation under different states and working conditions with different rotational speeds allows the superiority and effectiveness of the algorithm in this paper to be tested and has the feasibility of a practical application in engineering. Full article

This study presents a novel microfluidic mixer designed, fabricated, and characterized using additive manufacturing technology — stereolithography (SLA) — and harnessing capillarity principles achieved through microstructure patterning. Micromixers are integral components in optimizing mixing and reaction processes within microfluidic systems. The proposed microdevice employs a tank mixing method capable of blending two fluids. With a channel length of up to 6 mm, the process time is remarkably swift at 3 s, and the compact device measures 35 × 40 × 5 mm. The capillarity-driven working flow rates range from 1 $\mathrm{L}$/$\mathrm{s}$ to 37 $\mathrm{L}$/$\mathrm{s}$, facilitated by channel dimensions varying between 400 $\mathrm{m}$ and 850 $\mathrm{m}$. The total liquid volume within the device channels is 1652 $\mathrm{m}\mathrm{L}$ (6176 $\mathrm{L}$ including the supply tanks). The mix index, representing the homogeneity of the two fluids, is approximately 0.55 along the main channel. The manufacturing process, encompassing printing, isopropyl cleaning, and UV (ultraviolet) curing, is completed within 90 min. This microfluidic mixer showcases efficient mixing capabilities, rapid processing, and a compact design, marking it as a promising advancement in microfluidic technology. The new microfluidic mixer is a major step forward in microfluidic technology, providing a cost-effective and flexible solution for various uses. Its compatibility with SLA additive manufacturing allows for quick prototyping and design improvements, making it valuable for research and practical applications in chemistry, biology, and diagnostics. This study highlights the importance of combining advanced manufacturing techniques with basic fluid dynamics to create effective and easy-to-use microfluidic solutions. Full article

This study presents the predicted hydrodynamic characteristics of different rudder plane configurations on the stern of a full-scale submarine in deep water, which are obtained using the Reynolds-Averaged Navier–Stokes method in Ansys Fluent Solver. First, the results obtained for the X-rudder plane configuration are verified according to previous numerical and experimental results in order to assess the accuracy of the simulation procedure. The X-rudder plane, Y-rudder plane, and Cross-rudder plane configurations in deep water with deflection angles ranging from −21 degrees to +21 degrees are then simulated. Next, the hydrodynamic forces and moments of the Cross-plane, X-plane, and Y-plane rudder configurations obtained through simulation are analyzed using Taylor’s expansion to estimate the hydrodynamic coefficients. The obtained results demonstrate that the X-force of the X-plane rudder configuration is larger than the corresponding forces acting on the Cross-plane rudder and Y-plane rudder configurations. Meanwhile, the Y-force and Z-force of the X-plane rudder configuration are significantly greater than the corresponding forces of the left configurations. The same tendency can be seen in the moment of the X-plane rudder about the y- and z-axes. However, the roll moment induced by the Y-plane and Cross-plane rudder configurations is significantly larger than that under the X-plane rudder configuration. Full article

Yarrowia lipolytica is a robust yeast species that has gained significant attention as a biofactory for various biotechnological applications and undoubtedly can be referred to as a hidden treasure trove due to boasting a diverse array of enzymes with wide-ranging applications in multiple industries, including biofuel production, food processing, biotechnology, and pharmaceuticals. As the biotechnology field continues to expand, Y. lipolytica is poised to play a pivotal role in developing eco-friendly and economically viable bioprocesses. Its versatility and potential for large-scale production make it a promising candidate for sustainably addressing various societal and industrial needs. The current review article aimed to highlight the diverse enzymatic capabilities of Y. lipolytica and provide a detailed analysis of its relevance in biocatalysis, including the use of whole-cell catalysts and isolated enzymes. The review focused on wild-type yeast strains and their species-dependant properties and selected relevant examples of Y. lipolytica used as a host organism for overexpressing some enzymes. Furthermore, the application of Y. lipolytica’s potential in enantiomers resolution, lipids processing, and biodiesel synthesis, as well as the synthesis of polymers or esterification of different substrates for upgrading biologically active compounds, was discussed. Full article