This paper develops a thermoelectric (TE)–piezoelectric (PE) hybrid structure with the PE layer acting as both a support membrane and a sensor for the TE film for microelectronics applications. The TE and PE layers are assumed to be perfectly bonded mechanically and thermally but electrically shielded and insulated with each other. The thermo-electro-mechanical responses of the hybrid bilayer under the TE generator operation conditions are obtained, and the influence of the PE layer on the TE energy conversion efficiency is investigated. The numerical results for a Bi₂Te₃/PZT-5H bilayer structure show that large compressive stresses develop in both the PE and TE layers. With a decrease in the PE layer thickness, the magnitude of the maximum compressive stress in the PE layer increases whereas the maximum magnitude of the stress in the TE layer decreases. The numerical result of the TE energy conversion efficiency shows that increasing the PE layer thickness leads to lower energy conversion efficiencies. A nearly 40% reduction in the peak efficiency is observed with a PE layer of the same thickness as that of the TE layer. These results suggest that design of TE films with supporting/sensing membranes must consider both aspects of energy conversion efficiency and the thermomechanical reliability of both the TE and PE layers. Full article

This article examines the intersection of simulation-based education and the AI revolution in anesthesia medicine. With AI technologies reshaping perioperative management, simulation education faces both challenges and opportunities. The integration of AI into anesthesia practice offers personalized management possibilities, particularly in preoperative assessment and monitoring. However, the ethical, legal, and social implications necessitate careful navigation, emphasizing patient data privacy and accountability. Anesthesiologists must develop non-technical skills, including ethical decision-making and effective AI management, to adapt to the AI era. The experience-based medical education (EXPBME) framework underscores reflective learning and AI literacy acquisition, fostering lifelong learning and adaptation. Learner-centered approaches are pivotal in anesthesia education, promoting active engagement and self-regulated learning. Simulation-based learning, augmented by AI technologies, provides a dynamic platform for technical and non-technical skills development. Ultimately, by prioritizing non-technical skills, embracing learner-centered education, and responsibly leveraging AI technologies, anesthesiologists can contribute to enhanced patient care and safety in the evolving perioperative landscape. Full article

Graphene has achieved mass production via various preparative routes and demonstrated its uniqueness in many application fields for its intrinsically high electron mobility and thermal conductivity. However, graphene faces limitations in assembling macroscopic structures because of its hydrophobic property. Therefore, balancing high crystal quality and good aqueous dispersibility is of great importance in practical applications. Herein, we propose a tape-wrapping strategy to electrochemically fabricate water-dispersible graphene (w-Gr) with both excellent dispersibility (~4.5 mg/mL, stable over 2 months), and well-preserved crystalline structure. A large production rate (4.5 mg/min, six times faster than previous electrochemical methods), high yield (65.4% ≤5 atomic layers) and good processability are demonstrated. A mechanism investigation indicates that the rational design of anode configuration to ensure proper oxidation, deep exfoliation and unobstructed mass transfer is responsible for the high efficiency of this strategy. This simple yet efficient electrochemical method is expected to promote the scalable preparation and applications of graphene. Full article

Phycocyanin is a highly valued pigment present in Spirulina platensis biomass with applications in the food industry in terms of biorefinery concepts; specifically, its antioxidant and antimicrobial capacity are an advantage that could be incorporated into a food matrix. This study aims to use rice husk as an alternative culture medium for S. platensis biomass growth and phycocyanin extraction by ohmic heating processing using a 3D-printed reactor. S. platensis was cultivated in rice husk extract (RHE) from 0–100% (v/v). The highest content of microalgal biomass was 1.75 ± 0.01 g/L, with a specific growth rate of 0.125 ± 0.01 h⁻¹. For the phycocyanin extraction under an ohmic heating process, a 3D-printed reactor was designed and built. To optimize phycocyanin extraction, a central composite rotatable design (CCDR) was evaluated, with three factors: time (min), temperature (°C), and pH. The highest phycocyanin content was 75.80 ± 0.98 mg/g in S. platensis biomass grown with rice husk extract. Ohmic heating is a promising method for rapid phycocyanin extraction, and rice husk as a culture medium is an alternative for the growth of S. platensis biomass in the integration of second- and third-generation biorefineries. Full article

Background: The application of personalized cancer treatment based on genetic information and surgical samples has begun in the field of cancer medicine. However, a biopsy may be painful for patients with advanced diseases that do not qualify for surgical resection. Patient-derived xenografts (PDXs) are cancer models in which patient samples are transplanted into immunodeficient mice. PDXs are expected to be useful for personalized medicine. The aim of this study was to establish a PDX from body fluid (PDX-BF), such as peritoneal and pleural effusion samples, to provide personalized medicine without surgery. Methods: PDXs-BF were created from patients with ovarian cancer who had positive cytology findings based on peritoneal and pleural effusion samples. PDXs were also prepared from each primary tumor. The pathological findings based on immunohistochemistry were compared between the primary tumor, PDX, and PDX-BF. Further, genomic profiles and gene expression were evaluated using DNA and RNA sequencing to compare primary tumors, PDXs, and PDX-BF. Results: Among the 15 patients, PDX-BF was established for 8 patients (5 high-grade serous carcinoma, 1 carcinosarcoma, 1 low-grade serous carcinoma, and 1 clear cell carcinoma); the success rate was 53%. Histologically, PDXs-BF have features similar to those of primary tumors and PDXs. In particular, PDXs-BF had similar gene mutations and expression patterns to primary tumors and PDXs. Conclusions: PDX-BF reproduced primary tumors in terms of pathological features and genomic profiles, including gene mutation and expression. Thus, PDX-BF may be a potential alternative to surgical resection for patients with advanced disease. Full article

Despite reductions in bacterial infection and enhanced success rate, the widespread use of systemic antibiotic prophylaxis in implant dentistry is controversial. This use has contributed to the growing problem of antimicrobial resistance, along with creating significant health and economic burdens. The basic mechanisms that cause implant infection can be targeted by new prevention and treatment methods which can also lead to the reduction of systemic antibiotic exposure and its associated adverse effects. This review aims to summarize advanced biomaterial strategies applied to implant components based on anti-pathogenic mechanisms and immune balance mechanisms. It emphasizes that modifying the dental implant surface and regulating the early immune response are promising strategies, which may further prevent or slow the development of peri-implant infection, and subsequent failure. Full article

This study presents a numerical approach to the design and optimization of centrifugal impellers used in the pumps of active thermal control systems of spacecraft. Although launch costs have shrunk in the last decade, the performance requirements, such as efficiency and reliability, have increased, as such systems are required to work up to 15 years, depending on the mission. To that effect, our paper deals with the first step in this pump design, namely the hydraulic optimization of the impeller. Constructively, this type of impeller allows for certain balancing systems and labyrinth seals to be applied in a more effective way, as well as allowing for additive manufacturing methods to be used—however, details regarding these aspects are beyond the scope of the current paper. By combining empirical formulas, computational fluid dynamics (CFD) analysis, and artificial neural networks (ANNs), the research focuses on achieving high efficiency and fast manufacturing. A series of geometries have been sized and validated using steady-state RANS (Reynolds Averaged Navier-Stokes) simulations, leading to the identification of the most efficient configuration. Subsequent optimization using an ANN resulted in a refined impeller design with notable improvements in hydraulic performance: a 3.55% increase in efficiency and a 7.9% increase in head. Key parameters influencing impeller performance, including blade number, incidence, and backsweep angles, are identified. This approach offers a comprehensive method to address the evolving requirements of space missions and contributes to the advancement of centrifugal pump technology in the space domain. Full article

A batch of ZnO thin films, pure and doped with molybdenum (up to 2 mol %), were prepared using the spray pyrolysis technique on glass and silicon substrates. The effect of molybdenum concentration on the morphology, structure and optical properties of the films was investigated. X-ray diffraction (XRD) results show a wurtzite polycrystalline crystal structure. The average crystallite size increases from 30 to 80 nm with increasing molybdenum content. Scanning electron microscopy (SEM) images demonstrate a smooth and homogeneous surface with densely spaced nanocrystalline grains. The number of nuclei increases, growing over the entire surface of the substrate with uniform grains, when the molybdenum concentration is increased to 2 mol %. The estimated root mean square (RMS) roughness values for the undoped and doped with 1 mol % and 2 mol % of ZnO thin films, defined by atomic force microscopy (AFM), are 6.12, 23.54 and 23.83 nm, respectively. The increase in Mo concentration contributes to the increase in film transmittance. Full article

Neuroinflammation, a hallmark of various central nervous system disorders, is often associated with oxidative stress and neuronal or oligodendrocyte cell death. It is therefore very interesting to target neuroinflammation pharmacologically. One therapeutic option is the use of nutraceuticals, particularly apigenin. Apigenin is present in plants: vegetables (parsley, celery, onions), fruits (oranges), herbs (chamomile, thyme, oregano, basil), and some beverages (tea, beer, and wine). This review explores the potential of apigenin as an anti-inflammatory agent across diverse neurological conditions (multiple sclerosis, Parkinson’s disease, Alzheimer’s disease), cancer, cardiovascular diseases, cognitive and memory disorders, and toxicity related to trace metals and other chemicals. Drawing upon major studies, we summarize apigenin’s multifaceted effects and underlying mechanisms in neuroinflammation. Our review underscores apigenin’s therapeutic promise and calls for further investigation into its clinical applications. Full article

The nature of the input features is one of the key factors indicating what kind of tools, methods, or approaches can be used in a knowledge discovery process. Depending on the characteristics of the available attributes, some techniques could lead to unsatisfactory performance or even may not proceed at all without additional preprocessing steps. The types of variables and their domains affect performance. Any changes to their form can influence it as well, or even enable some learners. On the other hand, the relevance of features for a task constitutes another element with a noticeable impact on data exploration. The importance of attributes can be estimated through the application of mechanisms belonging to the feature selection and reduction area, such as rankings. In the described research framework, the data form was conditioned on relevance by the proposed procedure of gradual discretisation controlled by a ranking of attributes. Supervised and unsupervised discretisation methods were employed to the datasets from the stylometric domain and the task of binary authorship attribution. For the selected classifiers, extensive tests were performed and they indicated many cases of enhanced prediction for partially discretised datasets. Full article

Testosterone is integral to men’s sexual and overall health, but there is a gradual decline in the ageing male. The topical administration of testosterone is a valuable option as a supplement (replacement) therapy to alleviate hypogonadal symptoms. The clinical efficacy of a compounded testosterone 5% topical gel was assessed retrospectively in a male patient in his seventies by evaluating the laboratory testing of the serum total testosterone and the results of a validated androgen deficiency questionnaire. After treatment, the patient’s hypogonadal symptoms improved and the serum total testosterone level achieved was considered clinically optimal. The skin permeation of the testosterone topical gel (biological testing) was evaluated in vitro using the Franz finite dose model and human cadaver skin, and it is shown that testosterone can penetrate into and through ex vivo human skin. Testosterone therapy is often prescribed for extended periods, and consequently, it is crucial to determine the beyond-use date of the compounded formulations. The analytical testing involved a valid, stability-indicating assay method for compounded testosterone 0.5% and 20% topical gels. This multidisciplinary study shows evidence supporting topically applied testosterone’s clinical efficacy and the compounded formulations’ extended stability. Personalized, topical testosterone therapy is a promising alternative in current therapeutics for hypogonadal patients. Full article

Heavy metals in flue gas desulfurization (FGD) gypsum from coal-fired power plants are at risk of releaching during the processes of stockpiling and resource utilization. In this study, the effects of organosulfur chelators dithiocarbamate (DTC) and trisodium trithiocyanate-15 (TMT-15) on the solidification characteristics of heavy metals in desulphurized gypsum under different mass fractions, pH values, water contents and reaction times were investigated. The chemical composition and morphology were analyzed by inductively coupled plasma atomic emission spectrometer (ICP-AES) and scanning electron microscope (SEM). The experiments showed that both DTC and TMT-15 were effective at stabilizing the heavy metals in the FGD gypsum, with more than a 50% curing effect for all the heavy metals except Pb. DTC showed a better stabilization for Pb, Hg, Cu, Zn, and Cr, and TMT-15 showed a better curing effect for Cd. The solidified gypsum had good heavy metal stability in low-water-content environments. Increasing the mass fraction, reaction time, and pH decreased the heavy metal leaching, and the mass fraction had the greatest effect on the total heavy metal leaching concentration, followed by the reaction time and pH value. Full article

The recovery of sulfuric acid in the presence of Zr(IV) and Hf(IV) was studied via solvent extraction using TEHA (tri-2-ethylhexyl amine) and its mixtures. A solidification phenomenon occurred in the loaded organic phase when a single TEHA was employed in the extraction of 1 to 5 M H₂SO₄. Octanol, decanol and TBP (tri butyl phosphate) were mixed with TEHA, separately, to prevent the solidification of sulfuric-acid-loaded organic. Due to the relatively high aqueous solubility of octanol and decanol, the mixture of TEHA + TBP was selected as the optimal system for the extraction of H₂SO₄. Simulated counter-current extraction and stripping experiments were performed on the basis of the McCabe–Thiele diagrams, indicating that sulfuric acid could be reduced by TEHA + TBP from 4.2 to around 0.5 M without Zr(IV) and Hf(IV) extraction and recovered by its complete stripping with water. The proposed sulfuric acid recovery step would contribute to the completion of the closed-circuit of the Zr(IV) and Hf(IV) separation process in our previous work and help to re-separate the remaining Zr(IV) and Hf(IV) in the sulfuric acid stripping solution. Full article

The invasive Argentine ant (Linepithema humile) poses a significant threat to ecosystem stability worldwide. In Mediterranean citrus ecosystems, its spread may be limited by interactions with dominant native ant species. We conducted laboratory experiments to investigate the competitive dynamics between Argentine ants and two major native species, Tapinoma nigerrimum and Lasius grandis. At the individual level, both native species exhibited superior competitive performance, attributed to their larger body sizes and potential differences in chemical defences. At the colony level, T. nigerrimum demonstrated efficiency in interference competition, successfully defending food resources from Argentine ants. However, the Argentine ant exhibited higher recruitment capacity, albeit it was density-dependent. Our findings support the hypothesis that dominant native ants can serve as barriers against Argentine ant invasion in citrus ecosystems, highlighting the importance of interspecific competition in shaping community dynamics and invasive species management. This study underscores the potential role of native ant species in mitigating the impacts of invasive ants on ecosystem functioning and biodiversity conservation in agricultural landscapes, offering valuable insights for invasive species management strategies in Mediterranean citrus ecosystems. Full article

The global incidence of Type 2 diabetes (T2D) is on the rise, fueled by factors such as obesity, sedentary lifestyles, socio-economic factors, and ethnic backgrounds. T2D is a multifaceted condition often associated with various health complications, including adverse effects on bone health. This study aims to assess key biomarkers linked to bone health and remodeling—Osteoprotegerin (OPG), Receptor Activator of Nuclear Factor Kappa-Β Ligand (RANKL), and Glycoprotein Non-Metastatic Melanoma Protein B (GPNMB)—among individuals with diabetes while exploring the impact of ethnicity on these biomarkers. A cross-sectional analysis was conducted on a cohort of 2083 individuals from diverse ethnic backgrounds residing in Kuwait. The results indicate significantly elevated levels of these markers in individuals with T2D compared to non-diabetic counterparts, with OPG at 826.47 (405.8) pg/mL, RANKL at 9.25 (17.3) pg/mL, and GPNMB at 21.44 (7) ng/mL versus 653.75 (231.7) pg/mL, 0.21 (9.94) pg/mL, and 18.65 (5) ng/mL in non-diabetic individuals, respectively. Notably, this elevation was consistent across Arab and Asian populations, except for lower levels of RANKL observed in Arabs with T2D. Furthermore, a positive and significant correlation between OPG and GPNMB was observed regardless of ethnicity or diabetes status, with the strongest correlation (r = 0.473, p < 0.001) found among Arab individuals with T2D. Similarly, a positive and significant correlation between GPNMB and RANKL was noted among Asian individuals with T2D (r = 0.401, p = 0.001). Interestingly, a significant inverse correlation was detected between OPG and RANKL in non-diabetic Arab individuals. These findings highlight dysregulation in bone remodeling markers among individuals with T2D and emphasize the importance of considering ethnic variations in T2D-related complications. The performance of further studies is warranted to understand the underlying mechanisms and develop interventions based on ethnicity for personalized treatment approaches. Full article

Spent coffee grounds (SCGs) constitute the main solid residue of the coffee brewing process. SCGs are generated in significant amounts daily, worldwide. The effective management of this waste through biological processes is still an unresolved problem. In this study, the application of hydrodynamic cavitation (HC) as a pre-treatment method for improving the biodegradability of SCGs suspended in municipal wastewater was proposed. An orifice plate with a conical concentric hole having inlet/outlet diameter of 3/10 mm was applied as the cavitation inducer. Three inlet pressures were chosen: 3, 5 and 7 bar. The effects in time intervals of 0, 5, 10, 20, 30 and 45 min were evaluated. The application of HC led to enhanced biodegradability for each case. The results of multi-criteria decision indicated that the most efficient combination in terms of biodegradability and energy usage was obtained at the pressure of 5 bar and duration of 20 or 30 min, depending on the adopted weights. The improvements of DOC/TOC (dissolved organic carbon/total organic carbon) ratio were 57% and 71%, as compared to the untreated samples. The release of caffeine was found at pressures of 5 and 7 bar. However, at 5 bar, this effect was noticed for the longest times, 30 and 45 min, respectively. Full article

An efficient access to the novel 5-(aryl)amino-1,2,3-triazole-containing 2,1,3-benzothiadiazole derivatives has been developed. The method is based on 1,3-dipolar azide–nitrile cycloaddition followed by Buchwald–Hartwig cross-coupling to afford the corresponding N-aryl and N,N-diaryl substituted 5-amino-1,2,3-triazolyl 2,1,3-benzothiadiazoles under NHC-Pd catalysis. The one-pot diarylative Pd-catalyzed heterocyclization opens the straightforward route to triazole-linked carbazole-benzothiadiazole D-A systems. The optical and electrochemical properties of the compound obtained were investigated to estimate their potential application as emissive layers in OLED devises. The quantum yield of photoluminescence (PLQY) of the synthesized D-A derivatives depends to a large extent on electron-donating strengths of donor (D) component, reaching in some cases the values closed to 100%. Based on the most photoactive derivative and wide bandgap host material mCP, a light-emitting layer of OLED was made. The device showed a maximum brightness of 8000 cd/m² at an applied voltage of 18 V. The maximum current efficiency of the device reaches a value of 3.29 cd/A. Full article

In the field of lithium-ion batteries, the challenges posed by the low melting point and inadequate wettability of conventional polyolefin separators have increased the focus on ceramic-coated separators. This study introduces a highly efficient and stable boehmite/polydopamine/polyethylene (AlOOH-PDA-PE) separator. It is crafted by covalently attaching functionalized nanosized boehmite (γ-AlOOH) whiskers onto polyethylene (PE) surfaces. The presence of a covalent bond increases the stability at the interface, while amino groups on the surface of the separator enhance the infiltration of the electrolyte and facilitate the diffusion of lithium ions. The PE-PDA-AlOOH separator, when used in lithium-ion batteries, achieves a discharge capacity of 126 mAh g⁻¹ at 5 C and retains 97.1% capacity after 400 cycles, indicating superior cycling stability due to its covalently bonded ceramic surface. Thus, covalent interface modification is a promising strategy to prevent delamination of ceramic coatings in separators. Full article

Liver transplant patients are frail subjects due to lifelong therapy with immunosuppressants. In these patients, comorbidity and polytherapy increase the risk of adverse drug reactions. In this study, we report the development of hyponatremia, probably related to pantoprazole in a liver transplant patient. Sertraline dismission and treatment with sodium chloride did not improve clinical symptoms and laboratory levels. Pantoprazole dismission induced an improvement in clinical symptoms and the normalization of sodium levels. A five-month follow-up revealed the absence of clinical symptoms and normal serum sodium levels. Full article

Background. Knee and hip arthroplasty are two of the most frequently performed procedures in orthopaedic surgery. They are associated with positive patient-reported outcomes and significant improvements in quality of life for patients. Despite this, there may be room for further progress by quantifying functional improvements with gait analysis. Our study therefore aims to characterise the disease-specific gait pattern of participants with knee and hip osteoarthritis undergoing total joint replacement using a single chest-based wearable sensor. Methods. Twenty-nine participants awaiting total hip replacement and 28 participants awaiting total knee replacement underwent three-dimensional motion analysis with inertial wearable sensors. These gait metrics were then compared with 28 healthy controls of similar ages. Differences in gait metrics were evaluated using a T-test. The participants were recruited through a single centre to participate in this cross-sectional observational study. Participants with osteoarthritis severity sufficient to warrant surgical intervention were considered for inclusion in our study. The participants were instructed to walk 15–120 m in a hospital environment while fitted with a chest-based wearable sensor. Results. In total, three domains were evaluated, including spatiotemporal, variability and asymmetry parameters. There were marked variations in the gait asymmetry parameters and step length variation in both the hip and knee osteoarthritis patients compared with the healthy controls. The magnitude of gait deterioration in terms of step length asymmetry was greater on average in the hip osteoarthritis group than the knee group. The hip osteoarthritis (+180%, p < 0.001) and knee osteoarthritis (+129%, p = 0.001) groups demonstrated marked differences in step length asymmetry. Discussion. A single chest-based sensor was found to be capable of detecting pathological gait signatures in osteoarthritis patients when compared with age-matched controls. Future studies should compare pre- and postoperative changes to disease-specific gait impairments to validate the use of wearable sensors as a clinical adjunct. Full article

The economic return for peanut (Arachis hypogaea L.) in Ghana is often low due to limitations in the availability of inputs or their adoption, which are needed to optimize yield. Six experiments were conducted in Ghana in 2020 and 2021 to determine the impact of planting date, cultivar, fertilization, pest management practices, and harvest date on peanut yield, financial return, and pest reaction. A wide range of interactions among these treatment factors were often observed for infestations of aphids (Aphis gossypii Glover); groundnut rosette disease (Umbravirus: Tombusviridaee); millipedes (Peridontopyge spp.); white grubs (Schyzonicha spp.); wireworms (Conoderus spp.); termites (Microtermes and Odontotermes spp.); canopy defoliation as a result of early leaf spot disease caused by Passalora arachidicola (Hori) and late leaf spot caused by Nothopassalora personata (Berk. and M. A. Curtis); and the scarification and boring of pods caused by arthropod feeding. Pod yield and economic return increased for the cultivar Chitaochi and Sarinut 2 when fertilizer was applied and when fertilizer was applied at early, mid-, and late planting dates. Pod yield and economic return increased when a combination of locally derived potassium soaps was used for aphid suppression and one additional hand weeding was used in the improved pest management practice compared with the traditional practice without these inputs. Pearson correlations for yield and economic return were negatively correlated for all pests and damage caused by pests. The results from these experiments can be used by farmers and their advisors to develop production packages for peanut production in Ghana. Full article

The infinite series solution to the boundary-value problems of Laplace’s equation with discontinuous Dirichlet boundary conditions was found by using the basic method of separation of variables. The merit of this paper is that the closed-form solution, or the singular similarity solution in the semi-infinite strip domain and the first-quadrant domain, can be generated from the basic infinite series solution in the rectangular domain. Moreover, based on the superposition principle, the infinite series solution in the rectangular domain can be related to the singular similarity solution in the semi-infinite strip domain. It is proven that the analytical source-type singular behavior in the infinite series solution near certain singular points in the rectangular domain can be revealed from the singular similarity solution in the semi-infinite strip domain. By extending the boundary of the rectangular domain, the infinite series solution to Laplace’s equation in the first-quadrant domain can be derived to obtain the analytical singular similarity solution in a direct and much easier way than by using the methods of Fourier transform, images, and conformal mapping. Full article