The 2023 MDPI Annual Report has
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14 pages, 3134 KiB  
Article
Synergisms between Surfactants, Polymers, and Alcohols to Improve the Foamability of Mixed Systems
by Luís Alves, Solange Magalhães, Cátia Esteves, Marco Sebastião and Filipe Antunes
J 2024, 7(2), 169-182; https://doi.org/10.3390/j7020010 (registering DOI) - 10 May 2024
Abstract
In order to produce detergents with improved performance and good market acceptability, it is crucial to develop formulations with improved foamability and cleaning performance. The use of a delicate balance of surfactants and additives is an appealing strategy to obtain good results and [...] Read more.
In order to produce detergents with improved performance and good market acceptability, it is crucial to develop formulations with improved foamability and cleaning performance. The use of a delicate balance of surfactants and additives is an appealing strategy to obtain good results and enables a reduction in the amount of chemicals used in formulations. Mixtures of hydrophobically modified linear polymers and surfactants, as well as balanced mixtures with co-surfactants and/or hydrotropes, are the most effective parameters to control foamability and foam stability. In the present study, the effect of the addition of hydrophobically modified linear polymers, nonionic co-surfactants and hydrotropes, and their mixtures to anionic and zwitterionic surfactant aqueous solutions was evaluated. It was found that the presence of the hydrophobically modified polymer (HM-P) prevented the bubbles from bursting, resulting in better stability of the foam formed using zwitterionic surfactant solutions. Also, the surfactant packing was inferred to be relevant to obtaining foamability. Mixtures of surfactants, in the presence of a co-surfactant or hydrotrope led, tendentially, to an increase in the critical packing parameter (CPP), resulting in higher foam volumes and lower surface tension for most of the studied systems. Additionally, it was observed that the good cleaning efficiency of the developed surfactant formulations obtained a higher level of fat solubilization compared to a widely used brand of commercial dishwashing detergent. Full article
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12 pages, 1176 KiB  
Systematic Review
Acute Chyloperitoneum with Small Bowel Volvulus: Case Series and Systematic Review of the Literature
by Teresa Sinicropi, Carmelo Mazzeo, Carmelo Sofia, Santino Antonio Biondo, Eugenio Cucinotta and Francesco Fleres
J. Clin. Med. 2024, 13(10), 2816; https://doi.org/10.3390/jcm13102816 (registering DOI) - 10 May 2024
Abstract
Introduction: Chyloperitoneum arises from lymph leakage into the abdominal cavity, leading to an accumulation of milky fluid rich in triglycerides. Diagnosis can be challenging, and mortality rates vary depending on the underlying cause, with intestinal volvulus being just one potential acute cause. Despite [...] Read more.
Introduction: Chyloperitoneum arises from lymph leakage into the abdominal cavity, leading to an accumulation of milky fluid rich in triglycerides. Diagnosis can be challenging, and mortality rates vary depending on the underlying cause, with intestinal volvulus being just one potential acute cause. Despite its rarity, our case series highlights chyloperitoneum associated with non-ischemic small bowel volvulus. The aims of our study include assessing the incidence of this association and evaluating diagnostic and therapeutic approaches. Material and Methods: We present two cases of acute abdominal peritonitis with suspected small bowel volvulus identified via contrast-enhanced computed tomography (CT). Emergency laparotomy revealed milky-free fluid and bowel volvulus. Additionally, we conducted a systematic review up to 31 October 2023, identifying 15 previously reported cases of small bowel volvulus and chyloperitoneum in adults (via the PRISMA scheme). Conclusions: Clarifying the etiopathogenetic mechanism of chyloperitoneum requires specific diagnostic tools. Magnetic resonance imaging (MRI) may be useful in non-emergency situations, while contrast-enhanced CT is employed in emergencies. Although small bowel volvulus infrequently causes chyloperitoneum, prompt treatment is necessary. The volvulus determines lymphatic flow obstruction at the base of the mesentery, with exudation and chyle accumulation in the abdominal cavity. Derotation of the volvulus alone may resolve chyloperitoneum without intestinal ischemia. Full article
(This article belongs to the Special Issue Minimally Invasive Emergency Surgery)
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11 pages, 1309 KiB  
Article
Formation of Organic Monolayers on KF-Etched Si Surfaces
by Tiexin Li, Zane Datson and Nadim Darwish
Surfaces 2024, 7(2), 358-368; https://doi.org/10.3390/surfaces7020022 (registering DOI) - 10 May 2024
Abstract
Silicon is the most commonly used material in the microelectronics industry, due to its inherent advantages of high natural abundance, low cost, and high purity, coupled with the chemical and electrical stability at the interface with its oxide. For molecular electronics applications, oxide-free [...] Read more.
Silicon is the most commonly used material in the microelectronics industry, due to its inherent advantages of high natural abundance, low cost, and high purity, coupled with the chemical and electrical stability at the interface with its oxide. For molecular electronics applications, oxide-free Si surfaces are widely used because of the relative ease of removing the oxide (SiOx) by chemical means, yielding a surface which forms strong covalent bonds with a wide range of chemical functional groups; another advantage is that these surfaces remain oxide-free in the absence of oxidising agents. Standard procedures require the use of either HF, NH4F, or a mixture of both as the etching solution; however, these two chemicals are highly corrosive and toxic, posing a significant risk to the experimentalist. Here, we report that for silicon wafers etched by using potassium fluoride, a less toxic chemical, the resulting surface is free of oxides and can be functionalized by self-assembled monolayers of 1,8-nonadiyne. To demonstrate this, Si/SiOx wafers were etched by using either KF or NH4F, followed by hydrosilylation with 1,8-nonadiyne and a click reaction of the terminal alkyne with azidomethylferrocene. The surface coverages and electron transfer kinetics of the ferrocene-terminated KF-etched surfaces are comparable to those formed by acidic fluoride etching procedures. This is the first study comparing the differences between surfaces functionalized by self-assembled monolayers of 1,8-nonadiyne which were etched by KF and NH4F. KF could be used as a replacement chemical for etching silicon wafers when a less corrosive and toxic chemical is required. Full article
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24 pages, 1774 KiB  
Article
Variable Pressure Difference Control Method for Chilled Water System Based on the Identification of the Most Unfavorable Thermodynamic Loop
by Tingting Chen and Yuhang Han
Buildings 2024, 14(5), 1360; https://doi.org/10.3390/buildings14051360 (registering DOI) - 10 May 2024
Abstract
A variable pressure differential fuzzy control method is proposed based on the online identification method for key parameters and the fuzzy subset inference fuzzy control method of the chilled water system network model. Firstly, a phase plane fuzzy identification method is proposed for [...] Read more.
A variable pressure differential fuzzy control method is proposed based on the online identification method for key parameters and the fuzzy subset inference fuzzy control method of the chilled water system network model. Firstly, a phase plane fuzzy identification method is proposed for the most unfavorable thermal loop. The study focuses on analyzing the trend of room temperature deviation and deviation change in different quadrants in the phase plane. Furthermore, we establish a chilled water pipe network model that recalculates flow variation in both the main pipe and each branch pipe section to eliminate the most unfavorable thermal loop. Finally, the test platform for the fan coil variable flow air conditioning water system was designed and constructed to meet the requirements of energy-saving regulation. Additionally, the network monitoring system for the test platform was completed. The calibration and debugging results demonstrate that the monitoring error is within ±5.0%, ensuring precise control of room temperature at the end of the branch within ±0.5 °C. Results demonstrate that our novel method exhibits superior stability in room temperature control compared to traditional linear variable pressure differential set point controls while achieving energy saving ranging from 4.7% to 6.5%. Full article
(This article belongs to the Section Building Energy, Physics, Environment, and Systems)
22 pages, 5833 KiB  
Article
A Novel Approach for Dermal Application of Pranoprofen-Loaded Lipid Nanoparticles for the Treatment of Post-Tattoo Inflammatory Reactions
by Guillermo De Grau-Bassal, Mireia Mallandrich, Lilian Sosa, Lupe Espinoza, Ana Cristina Calpena, Núria Bozal-de Febrer, María J. Rodríguez-Lagunas, María L. Garduño-Ramírez and María Rincón
Pharmaceutics 2024, 16(5), 643; https://doi.org/10.3390/pharmaceutics16050643 (registering DOI) - 10 May 2024
Abstract
Recently, the number of people acquiring tattoos has increased, with tattoos gaining significant popularity in people between 20 and 40 years old. Inflammation is a common reaction associated with tattooing. The purpose of this study was to evaluate a nanostructured lipid carrier loading [...] Read more.
Recently, the number of people acquiring tattoos has increased, with tattoos gaining significant popularity in people between 20 and 40 years old. Inflammation is a common reaction associated with tattooing. The purpose of this study was to evaluate a nanostructured lipid carrier loading pranoprofen (PRA-NLC) as a tattoo aftercare formulation to reduce the inflammation associated with tattooing. In this context, the in vitro drug release and the ex vivo permeation-through-human-skin tests using Franz cells were appraised. The tolerance of our formulation on the skin was evaluated by studying the skin’s biomechanical properties. In addition, an in vivo anti-inflammatory study was conducted on mice skin to evaluate the efficacy of the formulation applied topically after tattooing the animals. PRA-NLC showed a sustained release up to 72 h, and the amount of pranoprofen retained in the skin was found to be 33.48 µg/g/cm2. The formulation proved to be well tolerated; it increased stratum corneum hydration, and no signs of skin irritation were observed. Furthermore, it was demonstrated to be non-cytotoxic since the cell viability was greater than 80%. Based on these results, we concluded that PRA-NLC represents a suitable drug delivery carrier for the transdermal delivery of pranoprofen to alleviate the local skin inflammation associated with tattooing. Full article
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23 pages, 2209 KiB  
Article
Numerical Simulation of Effective Heat Recapture Ammonia Pyrolysis System for Hydrogen Energy
by Jian Tiong Lim, Eddie Yin-Kwee Ng, Hamid Saeedipour and Hiang Kwee Lee
Inventions 2024, 9(3), 56; https://doi.org/10.3390/inventions9030056 (registering DOI) - 10 May 2024
Abstract
This paper proposes a solution to address the challenges of high storage and transport costs associated with using hydrogen () as an energy source. It suggests utilizing ammonia () as a hydrogen carrier to produce onsite for hydrogen gas turbines. offers higher volumetric [...] Read more.
This paper proposes a solution to address the challenges of high storage and transport costs associated with using hydrogen () as an energy source. It suggests utilizing ammonia () as a hydrogen carrier to produce onsite for hydrogen gas turbines. offers higher volumetric hydrogen density compared to liquid , potentially reducing shipping costs by 40%. The process involves pyrolysis, which utilizes the heat waste from exhaust gas generated by gas turbines to produce and nitrogen (). Numerical simulations were conducted to design and understand the behaviour of the heat recapture decomposition system. The design considerations included the concept of the number of transfer units and heat exchanger efficiency, achieving a heat recapture system efficiency of up to 91%. The simulation of decomposition was performed using ANSYS, a commercial simulation software, considering wall surface reactions, turbulent flow, and chemical reaction. Parameters such as activation energy and pre-exponential factor were provided by a study utilizing a nickel wire for decomposition experiments. The conversion of reached up to 94% via a nickel-based catalyst within a temperature range of 823 K to 923 K which is the exhaust gas temperature range. Various factors were considered to compare the efficiency of the system, including the mass flow of , operating gauge pressure, mass flow of exhaust gas, among others. Result showed that pressure would not affect the conversion of at temperatures above 800 K, thus a lower amount of energy is required for a compression purpose in this approach. The conversion is maintained at 94% to 97% when lower activation energy is applied via a ruthenium-based catalyst. Overall, this study showed the feasibility of utilizing convective heat transfer from exhaust gas in hydrogen production by pyrolysis, and this will further enhance the development of as the potential carrier for onsite production in hydrogen power generation. Full article
32 pages, 5571 KiB  
Article
Waiting Strategy for the Dynamic Meal Delivery Routing Problem with Time-Sensitive Customers Using a Hybrid Adaptive Genetic Algorithm and Adaptive Large Neighborhood Search Algorithm
by Wenjie Wang and Shen Gao
Systems 2024, 12(5), 170; https://doi.org/10.3390/systems12050170 (registering DOI) - 10 May 2024
Abstract
In this paper, we study the dynamic meal delivery routing problem (MDRP) with time-sensitive customers. The multi-objective MDRP optimization model is developed to maximize customer satisfaction and minimize delay penalty cost and riding cost. To solve the dynamic MDRP, a novel waiting strategy [...] Read more.
In this paper, we study the dynamic meal delivery routing problem (MDRP) with time-sensitive customers. The multi-objective MDRP optimization model is developed to maximize customer satisfaction and minimize delay penalty cost and riding cost. To solve the dynamic MDRP, a novel waiting strategy is proposed to divide the dynamic problem into a series of static subproblems. This waiting strategy utilizes the decision threshold to determine rerouting points based on the number of dynamic meal orders. Meanwhile, time-sensitive priority is introduced to accelerate assignment and routing decisions for orders from customers with high time sensitivity. For each static subproblem, a hybrid AGA–ALNS algorithm that incorporates the adaptive genetic algorithm and adaptive large neighborhood search is developed to improve both the global and local search capabilities of the genetic algorithm. We validate the performance of the proposed waiting strategy and the AGA–ALNS algorithm through numerical instances. In addition, managerial insights are obtained from sensitivity analysis experiments. Full article
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12 pages, 1200 KiB  
Article
Yellow Pitahaya (Selenicereus megalanthus Haw.) Growth and Ripening as Affected by Preharvest Elicitors (Salicylic Acid, Methyl Salicylate, Methyl Jasmonate, and Oxalic Acid): Enhancement of Yield, and Quality at Harvest
by Alex Estuardo Erazo-Lara, María Emma García-Pastor, Pedro Antonio Padilla-González, María Serrano and Daniel Valero
Horticulturae 2024, 10(5), 493; https://doi.org/10.3390/horticulturae10050493 (registering DOI) - 10 May 2024
Abstract
Yellow pitahaya (Selenicereus megalanthus Haw.) is an exotic fruit with great potential for exportation in Ecuador. The research was carried out with the objective of evaluating the fruit growth and ripening as affected by four elicitors: salicylic acid (SA), methyl salicylate (MeSa), [...] Read more.
Yellow pitahaya (Selenicereus megalanthus Haw.) is an exotic fruit with great potential for exportation in Ecuador. The research was carried out with the objective of evaluating the fruit growth and ripening as affected by four elicitors: salicylic acid (SA), methyl salicylate (MeSa), methyl jasmonate (MeJa), and oxalic acid (OA), all of them at 1, 5, and 10 mM concentration, compared with untreated plants (control). For each elicitor, nine plants were selected, and on each plant, three fruits were marked to follow up the growth by measuring polar and equatorial diameters. At harvest, yield (kg plant−1 and number of fruits plant−1), fruit weight, percentage of pulp and skin, total soluble solids (TSS), titratable acidity (TA), and firmness were determined. Treated plants enhanced fruit size, crop yield, and fruit weight compared with control fruits, although results depended on the elicitor tested and applied doses. The highest and lowest TSS were found in 10 mM MeSa and 5 mM MeJa-treated fruit, respectively, while the highest TA content was shown in 5 mM SA. Firmness was only enhanced in MeJa-treated fruits. Overall, results suggest that preharvest use of elicitors could modulate the pitahaya ripening and could improve quality attributes at harvest. Full article
(This article belongs to the Collection Advances in Tropical Fruit Cultivation and Breeding)
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41 pages, 981 KiB  
Review
A Comprehensive Review of Fine Chemical Production Using Metal-Modified and Acidic Microporous and Mesoporous Catalytic Materials
by Joseph Lantos, Narendra Kumar and Basudeb Saha
Catalysts 2024, 14(5), 317; https://doi.org/10.3390/catal14050317 (registering DOI) - 10 May 2024
Abstract
Fine chemicals are produced in small annual volume batch processes (often <10,000 tonnes per year), with a high associated price (usually >USD 10/kg). As a result of their usage in the production of speciality chemicals, in areas including agrochemicals, fragrances, and pharmaceuticals, the [...] Read more.
Fine chemicals are produced in small annual volume batch processes (often <10,000 tonnes per year), with a high associated price (usually >USD 10/kg). As a result of their usage in the production of speciality chemicals, in areas including agrochemicals, fragrances, and pharmaceuticals, the need for them will remain high for the foreseeable future. This review article assesses current methods used to produce fine chemicals with heterogeneous catalysts, including both well-established and newer experimental methods. A wide range of methods, utilising microporous and mesoporous catalysts, has been explored, including their preparation and modification before use in industry. Their potential drawbacks and benefits have been analysed, with their feasibility compared to newer, recently emerging catalysts. The field of heterogeneous catalysis for fine chemical production is a dynamic and ever-changing area of research. This deeper insight into catalytic behaviour and material properties will produce more efficient, selective, and sustainable processes in the fine chemical industry. The findings from this article will provide an excellent foundation for further exploration and a critical review in the field of fine chemical production using micro- and mesoporous heterogeneous catalysts. Full article
(This article belongs to the Special Issue Microporous and Mesoporous Materials for Catalytic Applications)
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14 pages, 2233 KiB  
Article
The Effectiveness of Inflammatory Indexes in Assessing Oropharyngeal Cancer Prognosis
by Wooyoung Jang, Jad F. Zeitouni, Daniel K. Nguyen, Ismail S. Mohiuddin, Haven Ward, Anu Satheeshkumar and Yusuf Dundar
Surgeries 2024, 5(2), 377-390; https://doi.org/10.3390/surgeries5020031 (registering DOI) - 10 May 2024
Abstract
Background: Inflammation has long been a key tenet in the diagnosis and management of malignancies, likely contributing to cancer incidence, staging, and progression. Systemic inflammation, in particular, is often elevated prior to and during cancer development. Systemic inflammation in the context of cancer [...] Read more.
Background: Inflammation has long been a key tenet in the diagnosis and management of malignancies, likely contributing to cancer incidence, staging, and progression. Systemic inflammation, in particular, is often elevated prior to and during cancer development. Systemic inflammation in the context of cancer diagnosis and monitoring is measured by various inflammatory indexes such as the systemic inflammatory response index (SIRI), plasma-to-lymphocyte ratio (PLR), systemic immune inflammation index (SII), and neutrophil-to-lymphocyte ratio (NLR). We set out to determine the relationship between pre- and post-treatment levels of these inflammatory indexes and the prognosis and outcomes of oropharyngeal cancer (OPC). Methods: A retrospective chart review was performed of 172 patients with OPC who underwent treatment for oropharyngeal cancer at University Medical Center in Lubbock, TX between May 2013 to May 2023. Sites of primary cancer were obtained through chart review. HPV infection status and differentiation of the tumor were noted for each patient. Treatment modalities were classified as surgery, radiation, chemotherapy, or concurrent chemotherapy and radiation. Treatment outcomes were classified based on recurrence and death secondary to disease. The relationships between treatment outcome and the described inflammatory indexes were evaluated. Appropriate parametric tests were selected based on the large number of variables. Results: Pre-treatment SIRI and Albumin levels were positively predictive in determining locoregional recurrence (p = 0.031 and p = 0.039). NLR, SII, and SIRI levels taken at three months post-treatment were also found to be positively predictive of locoregional recurrence (p = 0.005, p < 0.0005, and p = 0.007). SIRI taken at six months post-treatment was also found to be positively predictive of locoregional recurrence (p = 0.008). SII at six months post-treatment was found to be positively predictive of survival (p = 0.027). Conclusion: This study suggested that post-treatment levels of several inflammatory indexes, particularly SIRI, NLR, and SII, may be useful in determining the long-term outlook and recurrence of head and neck cancer following treatment. Full article
(This article belongs to the Special Issue Surgery in Head and Neck Cancer)
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11 pages, 1353 KiB  
Article
Selective Upregulation of Interleukin 1 Receptor Antagonist and Interleukin-8 in Fuchs’ Endothelial Corneal Dystrophy with Accompanying Cataract
by Rafał Fiolka, Edward Wylęgała, Michał Toborek, Jowita Adamczyk-Zostawa, Zenon P. Czuba and Adam Wylęgała
J. Clin. Med. 2024, 13(10), 2815; https://doi.org/10.3390/jcm13102815 (registering DOI) - 10 May 2024
Abstract
(1) Background: Patients with Fuchs’ endothelial corneal dystrophy (FECD) may have coexisting cataracts and, therefore, may require a cataract surgery, which poses challenges due to potential endothelial cell damage. FECD is a degenerative eye disease of unclear etiology, with inflammatory cytokines maybe [...] Read more.
(1) Background: Patients with Fuchs’ endothelial corneal dystrophy (FECD) may have coexisting cataracts and, therefore, may require a cataract surgery, which poses challenges due to potential endothelial cell damage. FECD is a degenerative eye disease of unclear etiology, with inflammatory cytokines maybe playing an important role in its development and progression. The present study aimed to investigate the cytokine profile in the aqueous humor of FECD eyes with cataract. (2) Methods: Fifty-two patients were included in the study, 26 with FECD + cataract and 26 with cataract as a control group. Samples of the aqueous humor were analyzed for pro- and anti-inflammatory cytokines using a Bio-Plex 200 system. (3) Results: Interleukin 1 receptor antagonist (IL-1Ra) and interleukin IL-8 levels were significantly higher in the aqueous humor of FECD + cataract patients compared to the control/cataract group. Moreover, the levels of anti-inflammatory IL-10 showed a strong trend to be higher in the FECD + cataract group compared to the control group. In contrast, there were no statistically significant differences in IL-1β, IL-6, IL-4, IL-10, IL-13, IL-17A, and tumor necrosis factor TNF-α between the groups. (4) Conclusions: Presented research contributes to a better understanding of FECD pathogenesis. Elevated levels of IL-1Ra and IL-8 may serve as a defense mechanism in people with FECD and coexisting cataract. Full article
(This article belongs to the Section Ophthalmology)
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20 pages, 3462 KiB  
Article
Improving the Properties of Gelatin-Based Films by Incorporation of “Pitanga” Leaf Extract and Crystalline Nanocellulose
by Larissa Tessaro, Ana Gabrielle R. Pereira, Milena Martelli-Tosi and Paulo José do Amaral Sobral
Foods 2024, 13(10), 1480; https://doi.org/10.3390/foods13101480 (registering DOI) - 10 May 2024
Abstract
Biopolymer-based films can be activated by the incorporation of active compounds into their matrix. Plant extracts are rich in phenolic compounds, which have antimicrobial and/or antioxidant properties. The aim of this study was to produce gelatin-based active films and nanocomposite films incorporated with [...] Read more.
Biopolymer-based films can be activated by the incorporation of active compounds into their matrix. Plant extracts are rich in phenolic compounds, which have antimicrobial and/or antioxidant properties. The aim of this study was to produce gelatin-based active films and nanocomposite films incorporated with “pitanga” (Eugenia uniflora L.) leaf extract (PLE) and/or crystalline nanocellulose extracted from soybean straw (CN), and to study the physicochemical, functional, microstructural, thermal, UV/Vis light barrier, and antioxidant properties of these materials. PLE enhanced some film properties, such as tensile strength (from 30.2 MPa to 40.6 MPa), elastic modulus (from 9.3 MPa to 11.3 MPa), the UV/Vis light barrier, and antioxidant activity, in addition to affecting the microstructural, surface, and color properties. These improvements were even more significant in nanocomposites simultaneously containing PLE and CN (59.5 MPa for tensile strength and 15.1 MPa for elastic modulus), and these composites also had lower moisture content (12.2% compared to 13.5–14.4% for other treatments) and solubility in water (from 48.9% to 44.1%). These improvements may be the result of interactions that occur between PLE’s polyphenols and gelatin, mainly in the presence of CN, probably due to the formation of a stable PLE–CN–gelatin complex. These results are relevant for the food packaging sector, as the activated nanocomposite films exhibited enhanced active, barrier, and mechanical properties due to the presence of PLE and CN, in addition to being entirely produced with sustainable components from natural and renewable sources. Full article
(This article belongs to the Special Issue Advances in Food Polymers and Colloids: Processing and Applications)
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20 pages, 1036 KiB  
Article
Combined Analysis of Neutrino and Antineutrino Charged Current Inclusive Interactions
by Juan M. Franco-Patino, Alejandro N. Gacino-Olmedo, Jesus Gonzalez-Rosa, Stephen J. Dolan, Guillermo D. Megias, Laura Munteanu, Maria B. Barbaro and Juan A. Caballero
Symmetry 2024, 16(5), 592; https://doi.org/10.3390/sym16050592 (registering DOI) - 10 May 2024
Abstract
This paper presents a combined analysis of muon neutrino and antineutrino charged-current cross sections at kinematics of relevance for the T2K, MINERvA and MicroBooNE experiments. We analyze the sum, difference and asymmetry of neutrino versus antineutrino cross sections in order to get a [...] Read more.
This paper presents a combined analysis of muon neutrino and antineutrino charged-current cross sections at kinematics of relevance for the T2K, MINERvA and MicroBooNE experiments. We analyze the sum, difference and asymmetry of neutrino versus antineutrino cross sections in order to get a better understanding of the nuclear effects involved in these processes. Nuclear models based on the superscaling behavior and the relativistic mean field theory are applied, covering a wide range of kinematics, from hundreds of MeV to several GeV, and the relevant nuclear regimes, i.e., from quasileastic reactions to deep inelastic scattering processes. The NEUT neutrino-interaction event generator, used in neutrino oscillation experiments, is also applied to the analysis of the quasielastic channel via local Fermi gas and spectral function approaches. Full article
(This article belongs to the Special Issue Symmetry and Neutrino Physics: Theory and Experiments)
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13 pages, 290 KiB  
Article
A Method to Explore the Best Mixed-Effects Model in a Data-Driven Manner with Multiprocessing: Applications in Public Health Research
by Hyemin Han
Eur. J. Investig. Health Psychol. Educ. 2024, 14(5), 1338-1350; https://doi.org/10.3390/ejihpe14050088 (registering DOI) - 10 May 2024
Abstract
In the present study, I developed and tested an R module to explore the best models within the context of multilevel modeling in research in public health. The module that I developed, explore.models, compares all possible candidate models generated from a set [...] Read more.
In the present study, I developed and tested an R module to explore the best models within the context of multilevel modeling in research in public health. The module that I developed, explore.models, compares all possible candidate models generated from a set of candidate predictors with information criteria, Akaike information criterion (AIC), and Bayesian information criterion (BIC), with multiprocessing. For testing, I ran explore.models with datasets analyzed in three previous studies in public health, which assumed candidate models with different degrees of model complexity. These three studies examined the predictors of psychological well-being, compliance with preventive measures, and vaccine intent during the COVID-19 pandemic. After conducting model exploration with explore.models, I cross-validated the nomination results with calculated model Bayes Factors to examine whether the model exploration was performed accurately. The results suggest that explore.models using AIC and BIC can nominate best candidate models and such nomination outcomes are supported by the calculated model Bayes Factors. In particular, all the identified models are superior to the full models in terms of model Bayes Factors. Also, by employing AIC and BIC with multiprocessing, explore.models requires a shorter processing time than model Bayes Factor calculations. These results indicate that explore.models is a reliable, valid, and feasible tool to conduct data-driven model exploration with datasets collected from multiple groups in research on health psychology and education. Full article
11 pages, 2279 KiB  
Article
Systemic Capillary Responses to Acute Exercise in Hypertensive Seniors: Insights from a Single-Center Pilot Study
by Misa Miura, Masahiro Kohzuki, Chie Saito, Satoshi Sakai, Hisashi Sugaya, Shingo Koyama, Yasushi Matsui, Tohru Sakuma, Osamu Ito and Kunihiro Yamagata
J. Clin. Med. 2024, 13(10), 2818; https://doi.org/10.3390/jcm13102818 (registering DOI) - 10 May 2024
Abstract
Objective: The aim of this study was to investigate nailfold capillary parameters in community-dwelling individuals aged over 60 years who have hypertension and do not exercise regularly. Furthermore, the study examined the correlations between capillary function and other health-related indicators. Design: This study [...] Read more.
Objective: The aim of this study was to investigate nailfold capillary parameters in community-dwelling individuals aged over 60 years who have hypertension and do not exercise regularly. Furthermore, the study examined the correlations between capillary function and other health-related indicators. Design: This study was a single- center pilot trial. Setting: The study took place in the Faculty of Health, Tsukuba University of Technology, Japan. Participants: Hypertensive community-dwelling elderly people took part in the study. Intervention: Microcirculation was observed before and 1 min after an arm-curl exercise by means of capillary microscopy of the non-exercised limb. Additionally, we examined other health-related indicators. Methods: We measured the acute effects of reperfusion on nailfold density, flow, and diameters. Secondary outcomes included the correlations between microvascular parameters and other health-related indicators. We hypothesized that brief exercise could enhance microcirculation reperfusion and correlate with other health-related parameters. Results: There were 20 participants with a mean (SD) age of 67.1 (5.8) years. The capillary flow rate changed from 2.3 ± 6.7 to 2.7 ± 0.2 log µm/s (p < 0.01), and the capillary density changed from 0.8 ± 0.2 to 0.9 ± 0.1 log/mm (p < 0.01), which included a significant increase in the non-exercising limb. Significant correlations were observed between the nailfold capillary diameter and body fat mass, the capillary diameter and physical activity, and the capillary density and bone mineral density. Conclusions: The acute effects of exercise on high-risk elderly individuals can be safe, and even 1 of min exercise can potentially improve their nailfold capillary function, despite the brief time, compared to no exercise. The results indicate that capillaries have an impact on the function of the whole body. Thus, they may be a useful diagnostic tool for assessing nailfold capillaries. Full article
(This article belongs to the Special Issue Recent Progress in Rehabilitation Medicine—2nd Edition)
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33 pages, 1717 KiB  
Article
Can China’s Regional Industrial Chain Innovation and Reform Policy Make the Impossible Triangle of Energy Attainable? A Causal Inference Study on the Effect of Improving Industrial Chain Resilience
by Tianyu Lu and Hongyu Li
Energies 2024, 17(10), 2301; https://doi.org/10.3390/en17102301 (registering DOI) - 10 May 2024
Abstract
This study used a double machine learning model (based on the random forest algorithm) and spatial Durbin DIDs model to conduct quasi-natural experiments. The results are as follows: (1) innovation and reform policy regarding regional industrial chains as well as their resilience can [...] Read more.
This study used a double machine learning model (based on the random forest algorithm) and spatial Durbin DIDs model to conduct quasi-natural experiments. The results are as follows: (1) innovation and reform policy regarding regional industrial chains as well as their resilience can significantly and positively address the development of China’s impossible triangle coupling of energy; (2) implementing the innovation and reform policy for regional industrial chains in other regions can have a significant positive spatial transmission effect on the impossible triangle coupling coordinated development of energy in the region; (3) regional industrial chain resilience can produce a significant positive mediating effect between the innovation and reform policy of regional industrial chains and the safety, reliability, and economic feasibility of green and clean energy systems; (4) under the counterfactual framework, the mechanism path “innovation and reform policy of the regional industry chain→regional industry chain resilience→coordination degree of impossible triangle coupling of energy” has significantly positive direct and indirect effects in both the treatment group and the control group. However, “innovation and reform policy of the regional industrial chain→regional industrial chain resilience→the energy sector’s impossible triangle coupling coordination degree” and “innovation and reform policy of the regional industrial chain→leading power of the regional industrial chain→the energy sector’s impossible triangle coupling coordination degree” have significantly positive direct and indirect effects in the treatment group, but only the direct effect is significant in the control group. Full article
(This article belongs to the Section C: Energy Economics and Policy)
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15 pages, 1022 KiB  
Article
Do Young Consumers Care about Antioxidant Benefits and Resveratrol and Caffeic Acid Consumption?
by Cristina Ștefania Gălbău, Mihaela Badea and Laura Elena Gaman
Nutrients 2024, 16(10), 1439; https://doi.org/10.3390/nu16101439 (registering DOI) - 10 May 2024
Abstract
Resveratrol and caffeic acid are some of the most consumed antioxidants during the day, so their importance as sources and their benefits need to be evaluated and updated. This survey aimed not only to analyze whether young Romanian consumers are informed about the [...] Read more.
Resveratrol and caffeic acid are some of the most consumed antioxidants during the day, so their importance as sources and their benefits need to be evaluated and updated. This survey aimed not only to analyze whether young Romanian consumers are informed about the benefits of antioxidants in general, and resveratrol and caffeic acid in particular, but also to observe the degree of nutritional education of these participants. Young consumers know the concept of antioxidants relatively well; they managed to give examples of antioxidants and indicate their effects. The majority of those chosen drink wine and coffee, but many are unaware of their health advantages and antioxidant properties. Students are less familiar with the antioxidant chemicals resveratrol and caffeic acid. It is advised to have a thorough understanding of these significant antioxidants and their nutritional content as they are present in our regular diets, and further studies on different kinds of antioxidants are required to increase the awareness of people concerning their importance in daily life. Full article
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41 pages, 5360 KiB  
Article
Development and Calibration of a Phenomenological Material Model for Steel-Fiber-Reinforced High-Performance Concrete Based on Unit Cell Calculations
by Mangesh Pise, Dominik Brands and Jörg Schröder
Materials 2024, 17(10), 2247; https://doi.org/10.3390/ma17102247 (registering DOI) - 10 May 2024
Abstract
A phenomenological material model has been developed to facilitate the efficient numerical analysis of fiber-reinforced high-performance concrete (HPC). The formulation integrates an elasto-plastic phase-field model for simulating fractures within the HPC matrix, along with a superimposed one-dimensional elasto-plasticity model that represents the behavior [...] Read more.
A phenomenological material model has been developed to facilitate the efficient numerical analysis of fiber-reinforced high-performance concrete (HPC). The formulation integrates an elasto-plastic phase-field model for simulating fractures within the HPC matrix, along with a superimposed one-dimensional elasto-plasticity model that represents the behavior of the embedded fibers. The Drucker–Prager plasticity and one-dimensional von-Mises plasticity formulations are incorporated to describe the nonlinear material behavior of both the HPC matrix and the fibers, respectively. Specific steps are undertaken during the development and calibration of the phenomenological material model. In the initial step, an experimental and numerical analysis of the pullout test of steel fibers embedded in an HPC matrix is conducted. This process is used to calibrate the micro-mechanical model based on the elasto-plastic phase-field formulation for fracture. In the subsequent step, virtual experiments based on an ellipsoidal unit cell, also with the resolution of fibers (used as a representative volume element, RVE), are simulated to analyze the impact of fiber–matrix interactions and their physical properties on the effective material behavior of fiber-reinforced HPC. In the final step, macroscopic boundary value problems (BVPs) based on a cuboid are simulated on a single scale using the developed phenomenological material model. The resulting macroscopic stress–strain characteristics obtained from both types of simulations, namely simulations of virtual experiments and macroscopic BVPs, are compared. This comparison is utilized for the calibration of material parameters to obtain a regularized solution and to assess the effectiveness of the presented phenomenological material model. Full article
(This article belongs to the Topic Advances in Computational Materials Sciences)
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15 pages, 2920 KiB  
Article
Unavoidability and Functionality of Nervous System and Behavioral Randomness
by Carlos M. Gómez, Elena I. Rodríguez-Martínez and María A. Altahona-Medina
Appl. Sci. 2024, 14(10), 4056; https://doi.org/10.3390/app14104056 (registering DOI) - 10 May 2024
Abstract
The basic functioning of the central nervous system is based on the opening and closing of ionic channels in the membranes of neurons. The behavior of ionic channels is considered to be a random process with an exponential probability distribution function. The central [...] Read more.
The basic functioning of the central nervous system is based on the opening and closing of ionic channels in the membranes of neurons. The behavior of ionic channels is considered to be a random process with an exponential probability distribution function. The central limit theorem implies that the mean of the sum of random variables generates a distribution in which the new variable tends to be normally distributed. The theorem implicitly implies that randomness can be embedded in a certain probability distribution but does not disappear. The present report will explore the possible implications for the functioning of nervous system and behavior of the constituent neural randomness. The possible functionality of “noise” to increase the exploratory space of nervous and behavioral systems will be considered. Full article
(This article belongs to the Special Issue Computational and Mathematical Methods for Neuroscience)
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14 pages, 2317 KiB  
Article
Bypass Patency and Amputation-Free Survival after Popliteal Aneurysm Exclusion Significantly Depends on Patient Age and Medical Complications: A Detailed Dual-Center Analysis of 395 Consecutive Elective and Emergency Procedures
by Hannah Freytag, Marvin Kapalla, Floris Berg, Hans-Christian Arne Stroth, Tessa Reisenauer, Kerstin Stoklasa, Alexander Zimmermann, Christian Reeps, Christoph Knappich, Steffen Wolk and Albert Busch
J. Clin. Med. 2024, 13(10), 2817; https://doi.org/10.3390/jcm13102817 (registering DOI) - 10 May 2024
Abstract
Background/Objectives: A popliteal artery aneurysm (PAA) is traditionally treated by an open PAA repair (OPAR) with a popliteo–popliteal venous graft interposition. Although excellent outcomes have been reported in elective cases, the results are much worse in cases of emergency presentation or with [...] Read more.
Background/Objectives: A popliteal artery aneurysm (PAA) is traditionally treated by an open PAA repair (OPAR) with a popliteo–popliteal venous graft interposition. Although excellent outcomes have been reported in elective cases, the results are much worse in cases of emergency presentation or with the necessity of adjunct procedures. This study aimed to identify the risk factors that might decrease amputation-free survival (efficacy endpoint) and lower graft patency (technical endpoint). Patients and Methods: A dual-center retrospective analysis was performed from 2000 to 2021 covering all consecutive PAA repairs stratified for elective vs. emergency repair, considering the patient (i.e., age and comorbidities), PAA (i.e., diameter and tibial runoff vessels), and procedural characteristics (i.e., procedure time, material, and bypass configuration). Descriptive, univariate, and multivariate statistics were used. Results: In 316 patients (69.8 ± 10.5 years), 395 PAAs (mean diameter 31.9 ± 12.9 mm) were operated, 67 as an emergency procedure (6× rupture; 93.8% severe acute limb ischemia). The majority had OPAR (366 procedures). Emergency patients had worse pre- and postoperative tibial runoff, longer procedure times, and more complex reconstructions harboring a variety of adjunct procedures as well as more medical and surgical complications (all p < 0.001). Overall, the in-hospital major amputation rate and mortality rate were 3.6% and 0.8%, respectively. The median follow-up was 49 months. Five-year primary and secondary patency rates were 80% and 94.7%. Patency for venous grafts outperformed alloplastic and composite reconstructions (p < 0.001), but prolonged the average procedure time by 51.4 (24.3–78.6) min (p < 0.001). Amputation-free survival was significantly better after elective procedures (p < 0.001), but only during the early (in-hospital) phase. An increase in patient age and any medical complications were significant negative predictors, regardless of the aneurysm size. Conclusions: A popliteo–popliteal vein interposition remains the gold standard for treatment despite a probably longer procedure time for both elective and emergency PAA repairs. To determine the most effective treatment strategies for older and probably frailer patients, factors such as the aneurysm size and the patient’s overall condition should be considered. Full article
(This article belongs to the Special Issue Current Trends in Vascular and Endovascular Surgery)
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13 pages, 648 KiB  
Article
Clinical Evaluation of VITEK MS PRIME with PICKME Pen for Bacteria and Yeasts, and RUO Database for Filamentous Fungi
by Hyeyoung Lee, Jehyun Koo, Junsang Oh, Sung-Il Cho, Hyunjoo Lee, Hyun Ji Lee, Gi-Ho Sung and Jayoung Kim
Microorganisms 2024, 12(5), 964; https://doi.org/10.3390/microorganisms12050964 (registering DOI) - 10 May 2024
Abstract
The VITEK MS PRIME (bioMérieux, Marcy-l’Étoile, France), a newly developed matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) system, alongside the VITEK PICKME pen (PICKME), offers easy sample preparation for bacteria and yeasts. The VITEK MS PRIME also offers two software platforms [...] Read more.
The VITEK MS PRIME (bioMérieux, Marcy-l’Étoile, France), a newly developed matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) system, alongside the VITEK PICKME pen (PICKME), offers easy sample preparation for bacteria and yeasts. The VITEK MS PRIME also offers two software platforms for filamentous fungi: the IVD database and the RUO database. Our study evaluated its identification agreement on 320 clinical isolates of bacteria and yeasts, comparing PICKME and traditional wooden toothpick sampling techniques against MicroIDSys Elite (ASTA) results. Additionally, we assessed the IVD (v3.2) and SARAMIS (v4.16) RUO databases on 289 filamentous fungi against molecular sequencing. The concordance rates for species-level identification of bacteria and yeasts were about 89.4% (286/320) between the PICKME and wooden toothpick, and about 83.4–85.3% between the VITEK MS PRIME and ASTA MicroIDSys Elite. Retesting with PICKME improved concordance to 91.9%. For filamentous fungi, species-level identification reached 71.3% with the IVD database and 85.8% with RUO, which significantly enhanced basidiomycetes’ identification from 35.3% to 100%. Some strains in the IVD database, like Aspergillus versicolor, Exophiala xenobiotica, and Nannizzia gypsea, failed to be identified. The VITEK MS PRIME with PICKME offers reliable and efficient microorganism identification. For filamentous fungi, combined use of the RUO database can be beneficial, especially for basidiomycetes. Full article
(This article belongs to the Section Medical Microbiology)
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32 pages, 2247 KiB  
Review
Security Threats, Requirements and Recommendations on Creating 5G Network Slicing System: A Survey
by Shujuan Gao, Ruyan Lin, Yulong Fu, Hui Li and Jin Cao
Electronics 2024, 13(10), 1860; https://doi.org/10.3390/electronics13101860 (registering DOI) - 10 May 2024
Abstract
Network slicing empowers 5G with enhanced network performance and efficiency, cost saving, and better QoS and customer satisfaction, and expands the commercial application scenarios of 5G networks. However, the introduction of new techniques usually raises new security threats. Most of the existing works [...] Read more.
Network slicing empowers 5G with enhanced network performance and efficiency, cost saving, and better QoS and customer satisfaction, and expands the commercial application scenarios of 5G networks. However, the introduction of new techniques usually raises new security threats. Most of the existing works on 5G security only focus on 5G itself and do not analyze 5G network slicing security in detail. We consider network slices as a virtual logical network that can unite the subnetwork parts of 5G. If a 5G network slice has security problems or has been attacked, the entire 5G network will have security risks. In this paper, after synthesizing the existing literature, we analyze the security threats step by step through the lifecycle of 5G network slices, analyzing and summarizing more than 70 security threats in three major categories. Based on the security issues investigated, from a viewpoint of building a secure 5G network slicing system, we compiled 24 security requirements and proposed the corresponding recommendations for different scenarios of 5G network slicing. Finally, we collated the future research trends of 5G network slicing security. Full article
(This article belongs to the Special Issue Recent Advances in Reliability and Security in 5G/6G Mobile Networks)
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13 pages, 5352 KiB  
Article
Enhancing Gluten Network Formation and Bread-Making Performance of Wheat Flour Using Wheat Bran Aqueous Extract
by Cheng Li, Gengjun Chen, Michael Tilley, Richard Chen, Mayra Perez-Fajardo, Xiaorong Wu and Yonghui Li
Foods 2024, 13(10), 1479; https://doi.org/10.3390/foods13101479 (registering DOI) - 10 May 2024
Abstract
Wheat bran possesses diverse nutritional and functional properties. In this study, wheat bran aqueous extract (WBE) was produced and thoroughly characterized as a functional ingredient and improver for bakery application. The WBE contained 50.3% total carbohydrate, 24.5% protein, 13.0% ash, 6.7% soluble fiber, [...] Read more.
Wheat bran possesses diverse nutritional and functional properties. In this study, wheat bran aqueous extract (WBE) was produced and thoroughly characterized as a functional ingredient and improver for bakery application. The WBE contained 50.3% total carbohydrate, 24.5% protein, 13.0% ash, 6.7% soluble fiber, 2.9% insoluble fiber, and 0.5% β-glucan. Notably, adding 7.5% WBE significantly increased the bread-specific volume to 4.84 cm3/g, compared with the control of 4.18 cm3/g. Adding WBE also resulted in a remarkable improvement in dough properties. The WBE-enriched dough showed increased peak, setback, breakdown, and final viscosities, along with higher storage and loss modulus. Scanning electron microscopy analysis further revealed that the WBE promoted the aggregation of protein and starch within the dough. The extractable gliadin to glutenin ratio increased with 5 and 7.5% WBE additions, compared with the control and 2.5% WBE addition. WBE did not significantly alter the starch gelatinization temperature or dough extension properties. These findings demonstrate that the inclusion of WBE in wheat flour is a promising approach for producing high-quality bread that is enriched with dietary fiber and protein. Full article
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