The 2023 MDPI Annual Report has
been released!
 
20 pages, 5048 KiB  
Article
An Accurate Representation of the Number of bZIP Transcription Factors in the Triticum aestivum (Wheat) Genome and the Regulation of Functional Genes during Salt Stress
by Xin Liu, Selvakumar Sukumaran, Esteri Viitanen, Nupur Naik, Sameer Hassan and Henrik Aronsson
Curr. Issues Mol. Biol. 2024, 46(5), 4417-4436; https://doi.org/10.3390/cimb46050268 (registering DOI) - 07 May 2024
Abstract
Climate change is dramatically increasing the overall area of saline soils around the world, which is increasing by approximately two million hectares each year. Soil salinity decreases crop yields and, thereby, makes farming less profitable, potentially causing increased poverty and hunger in many [...] Read more.
Climate change is dramatically increasing the overall area of saline soils around the world, which is increasing by approximately two million hectares each year. Soil salinity decreases crop yields and, thereby, makes farming less profitable, potentially causing increased poverty and hunger in many areas. A solution to this problem is increasing the salt tolerance of crop plants. Transcription factors (TFs) within crop plants represent a key to understanding salt tolerance, as these proteins play important roles in the regulation of functional genes linked to salt stress. The basic leucine zipper (bZIP) TF has a well-documented role in the regulation of salt tolerance. To better understand how bZIP TFs are linked to salt tolerance, we performed a genome-wide analysis in wheat using the Chinese spring wheat genome, which has been assembled by the International Wheat Genome Sequencing Consortium. We identified 89 additional bZIP gene sequences, which brings the total of bZIP gene sequences in wheat to 237. The majority of these 237 sequences included a single bZIP protein domain; however, different combinations of five other domains also exist. The bZIP proteins are divided into ten subfamily groups. Using an in silico analysis, we identified five bZIP genes (ABF2, ABF4, ABI5, EMBP1, and VIP1) that were involved in regulating salt stress. By scrutinizing the binding properties to the 2000 bp upstream region, we identified putative functional genes under the regulation of these TFs. Expression analyses of plant tissue that had been treated with or without 100 mM NaCl revealed variable patterns between the TFs and functional genes. For example, an increased expression of ABF4 was correlated with an increased expression of the corresponding functional genes in both root and shoot tissues, whereas VIP1 downregulation in root tissues strongly decreased the expression of two functional genes. Identifying strategies to sustain the expression of the functional genes described in this study could enhance wheat’s salt tolerance. Full article
(This article belongs to the Special Issue Advanced Research in Wheat Genome and Breeding)
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14 pages, 1415 KiB  
Article
Algal Oil Mitigates Sodium Taurocholate-Induced Pancreatitis by Alleviating Calcium Overload, Oxidative Stress, and NF-κB Activation in Pancreatic Acinar Cells
by Yi Fang, Sung-Yen Lin, Chung-Hwan Chen and Hui-Chen Lo
Curr. Issues Mol. Biol. 2024, 46(5), 4403-4416; https://doi.org/10.3390/cimb46050267 (registering DOI) - 07 May 2024
Abstract
Acute pancreatitis (AP) is characterized by elevated intracellular Ca2+ concentrations, mitochondrial dysfunction, and oxidative stress in pancreatic acinar cells. Algal oil (AO) has demonstrated antioxidant and anti-inflammatory properties. This study aims to explore the effects of algal oil on the microenvironment of [...] Read more.
Acute pancreatitis (AP) is characterized by elevated intracellular Ca2+ concentrations, mitochondrial dysfunction, and oxidative stress in pancreatic acinar cells. Algal oil (AO) has demonstrated antioxidant and anti-inflammatory properties. This study aims to explore the effects of algal oil on the microenvironment of AP. Rat pancreatic acinar AR42J cells were pretreated with AO containing 0, 50, 100, or 150 μM of docosahexaenoic acid (DHA) 2 h prior to AP induction using sodium taurocholate (STC). After 1 h of STC treatment, AR42J cells exhibited a significant increase in intracellular Ca2+ concentration and the production of amylase, lipase, reactive oxygen species, and pro-inflammatory mediators, including tumor necrosis factor-α and interleukin-6. These STC-induced increases were markedly reduced in cells pretreated with AO. In comparison to cells without AO, those treated with a high dose of AO before STC exposure demonstrated a significant increase in mitochondrial membrane potential and a decrease in lipid peroxidation. Furthermore, STC-activated nuclear factor kappa-B (NF-κB) was attenuated in AO-pretreated cells, as evidenced by a significant decrease in activated NF-κB. In conclusion, AO may prevent damage to pancreatic acinar cells by alleviating intracellular Ca2+ overload, mitigating mitochondrial dysfunction, reducing oxidative stress, and attenuating NF-κB-targeted inflammation. Full article
(This article belongs to the Special Issue Molecular Research on Free Radicals and Oxidative Stress)
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20 pages, 2991 KiB  
Article
Morphological and Molecular Characters Differentiate Common Morphotypes of Atlantic Holopelagic Sargassum
by Amy N. S. Siuda, Aurélie Blanfuné, Skye Dibner, Marc Verlaque, Charles-François Boudouresque, Solène Connan, Deborah S. Goodwin, Valérie Stiger-Pouvreau, Frédérique Viard, Florence Rousseau, Valérie Michotey, Jeffrey M. Schell, Thomas Changeaux, Didier Aurelle and Thierry Thibaut
Phycology 2024, 4(2), 256-275; https://doi.org/10.3390/phycology4020014 (registering DOI) - 07 May 2024
Abstract
Since 2011, massive new strandings of holopelagic Sargassum have been reported on the coasts of the Caribbean, northern Brazil, Guiana, and West Africa, causing severe economic and ecological damage. Three common morphotypes (S. fluitans III, S. natans I, and S. natans VIII) [...] Read more.
Since 2011, massive new strandings of holopelagic Sargassum have been reported on the coasts of the Caribbean, northern Brazil, Guiana, and West Africa, causing severe economic and ecological damage. Three common morphotypes (S. fluitans III, S. natans I, and S. natans VIII) were identified as responsible for these catastrophic events, with dominance shifts between them over time. However, the taxonomic status of these holopelagic Sargassum morphotypes remains unclear. Using an integrative taxonomy framework, combining a morphological study and molecular analyses, this study aimed to clarify their taxonomic status. Morphological analyses of 54 characters revealed no intermediate form between the three morphotypes, with the overall shape, nature of the axis, and size and shape of blades and vesicles being the most discriminating. An analysis of mitochondrial (IGS, cox2, cox3, mt16S rRNA, and nad6) and plastid (rbcL) markers confirmed the genetic divergence among the three morphotypes, with a lower level of divergence between the two S. natans morphotypes. Without additional molecular characterization, these morphotypes cannot be classified as three distinct species. However, due to their distinct morphological characteristics and sympatry within drifting aggregations, a revision of holopelagic species names is proposed, with Sargassum fluitans var. fluitans (for S. fluitans III), Sargassum natans var. natans (for S. natans I), and S. natans var. wingei (for S. natans VIII). This revision provides necessary clarity on the species involved in inundations of the tropical Atlantic. Full article
(This article belongs to the Collection Sargassum Golden Tides, a Global Problem)
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8 pages, 1274 KiB  
Communication
Evaluation of the Plant Growth Regulator SPGP4 in Agricultural Crops: A Case Study in Oaxaca, México
by Guiee N. López-Castillo, Arnoldo Wong-Villareal, Judith Castellanos-Moguel, Gilberto Vela Correa, Sandra L. Cabrera-Hilerio, Mariana Miranda-Arámbula, Alan Carrasco-Carballo and Jesús Sandoval-Ramírez
Crops 2024, 4(2), 172-179; https://doi.org/10.3390/crops4020013 (registering DOI) - 07 May 2024
Abstract
The search for new plant growth regulators is a cornerstone of agricultural research; however, laboratory studies rarely go on to be evaluated in the field. This is because greater production is required, as well as longer studies. Particularly, brassinosteroids present these difficulties, and [...] Read more.
The search for new plant growth regulators is a cornerstone of agricultural research; however, laboratory studies rarely go on to be evaluated in the field. This is because greater production is required, as well as longer studies. Particularly, brassinosteroids present these difficulties, and although they have been evaluated in crops with good results, their high production cost gives rise to the search for new alternatives. 22-Oxocholestanes such as SPGP4, previously used in silico and in vitro studies, have shown great potential, so their evaluation in crops grown from native seeds from the study region becomes of interest. Based on these data, SPGP4 was evaluated under crop conditions in three agricultural plots located on the Isthmus of Tehuantepec region, Oaxaca, México. The seeds were treated with a 0.5 mg/L aqueous solution of the 22-Oxocholestane compound SPGP4 by imbibition one night before sown. Later, 45 days after sowing, a solution of 0.5 mg/L at a rate of 200 L per hectare was applied. At the production level, the bean harvest showed an increase in the range of 21.0–38.1%, and the corn harvest increased between 22 and 32%. In addition, the latter also demonstrated an increase in biomass production, given the increase in diameter and height observed in the corn plant. This indicates that SPGP4 functions as a regulator of plant growth at the crop level to increase both seed and biomass production. Full article
16 pages, 436 KiB  
Review
Effect of Boxing Exercises on the Functional Ability and Quality of Life of Individuals with Parkinson’s Disease: A Systematic Review
by Nikolaos Chrysagis, Georgia Trompouki, Dimitris Petropaulis, George A. Koumantakis, Georgios Krekoukias, Georgios Theotokatos, Emmanouil Skordilis and Vasiliki Sakellari
Eur. J. Investig. Health Psychol. Educ. 2024, 14(5), 1295-1310; https://doi.org/10.3390/ejihpe14050085 (registering DOI) - 07 May 2024
Abstract
Parkinson’s disease (PD) is a neurological disorder caused by the loss of dopamine-producing cells in the substantia nigra and characterized by motor and non-motor symptoms. Boxing is a type of complementary therapy to improve symptoms in PD. The purpose of the present study [...] Read more.
Parkinson’s disease (PD) is a neurological disorder caused by the loss of dopamine-producing cells in the substantia nigra and characterized by motor and non-motor symptoms. Boxing is a type of complementary therapy to improve symptoms in PD. The purpose of the present study was to examine the effect of boxing training on the functionality and quality of life of patients with PD. The literature search was performed on PubMed, Scopus, PEDro, Cochrane Library, and Google Scholar search engines. The PEDro scale was used to assess the methodological quality of the studies. This systematic review included three studies that examined disease severity, mobility, physical activity, balance, and quality of life. According to the PEDro scale criteria, the three articles included were of high methodological quality. Statistically significant improvements after the implementation of boxing training was shown for balance and quality of life in contrast to the other variables. Boxing training intervention programs had a positive effect on balance and quality of life in patients with PD; however, the results are conflicting regarding certain functionality variables. Therefore, it is necessary to conduct further research to examine the effectiveness of boxing training on the functionality and quality of life of patients with Parkinson’s disease. Full article
19 pages, 545 KiB  
Review
An Overview of Approaches and Methods for the Cognitive Workload Estimation in Human–Machine Interaction Scenarios through Wearables Sensors
by Sabrina Iarlori, David Perpetuini, Michele Tritto, Daniela Cardone, Alessandro Tiberio, Manish Chinthakindi, Chiara Filippini, Luca Cavanini, Alessandro Freddi, Francesco Ferracuti, Arcangelo Merla and Andrea Monteriù
BioMedInformatics 2024, 4(2), 1155-1173; https://doi.org/10.3390/biomedinformatics4020064 (registering DOI) - 07 May 2024
Abstract
Background: Human-Machine Interaction (HMI) has been an important field of research in recent years, since machines will continue to be embedded in many human actvities in several contexts, such as industry and healthcare. Monitoring in an ecological mannerthe cognitive workload (CW) of users, [...] Read more.
Background: Human-Machine Interaction (HMI) has been an important field of research in recent years, since machines will continue to be embedded in many human actvities in several contexts, such as industry and healthcare. Monitoring in an ecological mannerthe cognitive workload (CW) of users, who interact with machines, is crucial to assess their level of engagement in activities and the required effort, with the goal of preventing stressful circumstances. This study provides a comprehensive analysis of the assessment of CW using wearable sensors in HMI. Methods: this narrative review explores several techniques and procedures for collecting physiological data through wearable sensors with the possibility to integrate these multiple physiological signals, providing a multimodal monitoring of the individuals’CW. Finally, it focuses on the impact of artificial intelligence methods in the physiological signals data analysis to provide models of the CW to be exploited in HMI. Results: the review provided a comprehensive evaluation of the wearables, physiological signals, and methods of data analysis for CW evaluation in HMI. Conclusion: the literature highlighted the feasibility of employing wearable sensors to collect physiological signals for an ecological CW monitoring in HMI scenarios. However, challenges remain in standardizing these measures across different populations and contexts. Full article
(This article belongs to the Special Issue Feature Papers in Applied Biomedical Data Science)
52 pages, 4744 KiB  
Article
Force Metrology with Plane Parallel Plates: Final Design Review and Outlook
by Hamid Haghmoradi, Hauke Fischer, Alessandro Bertolini, Ivica Galić, Francesco Intravaia, Mario Pitschmann, Raphael A. Schimpl and René I. P. Sedmik
Physics 2024, 6(2), 690-741; https://doi.org/10.3390/physics6020045 (registering DOI) - 07 May 2024
Abstract
During the past few decades, abundant evidence for physics beyond the two standard models of particle physics and cosmology was found. Yet, we are tapping in the dark regarding our understanding of the dark sector. For more than a century, open problems related [...] Read more.
During the past few decades, abundant evidence for physics beyond the two standard models of particle physics and cosmology was found. Yet, we are tapping in the dark regarding our understanding of the dark sector. For more than a century, open problems related to the nature of the vacuum remained unresolved. As well as the traditional high-energy frontier and cosmology, technological advancement provides complementary access to new physics via high-precision experiments. Among the latter, the Casimir And Non-Newtonian force EXperiment (Cannex) has successfully completed its proof-of-principle phase and is going to commence operation soon. Benefiting from its plane parallel plate geometry, both interfacial and gravity-like forces are maximized, leading to increased sensitivity. A wide range of dark sector forces, Casimir forces in and out of thermal equilibrium, and gravity can be tested. This paper describes the final experimental design, its sensitivity, and expected results. Full article
(This article belongs to the Special Issue 75 Years of the Casimir Effect: Advances and Prospects)
14 pages, 646 KiB  
Article
Introduction of the Experimental Setup for the Investigation of the Novel Selective Melt Dispersion (SMD): A Directed Energy Deposition (DED) Process
by Sebastian F. Noller, Anja Pfennig and Matthias Dahlmeyer
Clean Technol. 2024, 6(2), 572-585; https://doi.org/10.3390/cleantechnol6020030 (registering DOI) - 07 May 2024
Abstract
This study focuses on developing an experimental setup to investigate the Selective Melt Dispersion (SMD), a Directed Energy Deposition (DED) process. SMD as a means of in-process joining (IPJ) aims to integrate components and assemblies during additive manufacturing, combining the advantages of various [...] Read more.
This study focuses on developing an experimental setup to investigate the Selective Melt Dispersion (SMD), a Directed Energy Deposition (DED) process. SMD as a means of in-process joining (IPJ) aims to integrate components and assemblies during additive manufacturing, combining the advantages of various processes for eco-friendly and economical resource utilization. The research initially analyzed DED systems and defined requirements for subsystems and the overall system. Critical subsystems, including the energy source, material feed, and others, were sequentially developed, and a proof of concept involved building 20 stacked welded tracks, validated through micrograph analysis. The study concludes by evaluating and discussing the fulfillment of the defined requirements. The system comprises a centrally arranged vibration-assisted powder feed; a laterally arranged laser incidence at a 45° angle; a kinematic structure where all axes are arranged on the workpiece, so the powder supply does not require movement; and a shield gas supply. Full article
(This article belongs to the Topic Clean Energy Technologies and Assessment)
21 pages, 1610 KiB  
Article
Environmental Impacts Associated with the Production and Packing of Persian Lemon in Mexico through Life-Cycle Assessment
by Eduardo Castillo-González, Lorena De Medina-Salas, Mario Rafael Giraldi-Díaz, Raúl Velásquez-De La Cruz and José Rafael Jiménez-Ochoa
Clean Technol. 2024, 6(2), 551-571; https://doi.org/10.3390/cleantechnol6020029 (registering DOI) - 07 May 2024
Abstract
In this study, the environmental impacts associated with the intensive production of Persian lemons are assessed, including the agricultural and packing phases of the fresh fruit. A life-cycle assessment (LCA) tool was used in accordance with the ISO 14040 and 14044 standards and [...] Read more.
In this study, the environmental impacts associated with the intensive production of Persian lemons are assessed, including the agricultural and packing phases of the fresh fruit. A life-cycle assessment (LCA) tool was used in accordance with the ISO 14040 and 14044 standards and implemented in SimaPro PhD (9.2) software. The life-cycle inventory database was primarily composed of data collected during field visits to local lemon orchards and the main packing company in the region. The functional unit was defined as 1 kg of packed fresh Persian lemons. The selected impact categories were the carbon footprint, water footprint, and energy footprint, and the results obtained for the defined functional unit were 405.8 g CO2 eq, 40.3 L of water, and 5.9 MJ, respectively. The industrial packing phase of the fruits had a greater impact on the carbon and energy footprints, mostly due to the manufacturing of packaging materials and cardboard boxes, followed by the transportation of supplies. Regarding the water footprint, the agricultural phase was identified as the most significant contributor to water consumption, primarily attributed to maintenance operations and the application of agrochemicals. Full article
17 pages, 1185 KiB  
Review
Current Status of Research on Wildland Fire Impacts on Soil Environment and Soil Organisms and Hotspots Visualization Analysis
by Zhichao Cheng, Song Wu, Dan Wei, Hong Pan, Xiaoyu Fu, Xinming Lu and Libin Yang
Fire 2024, 7(5), 163; https://doi.org/10.3390/fire7050163 (registering DOI) - 07 May 2024
Abstract
Ecosystems are frequently disturbed by fires that have an important impact on the soil environment and the composition of soil organisms. In order to provide a baseline for the current research and identify trends on the effects of wildland fire on soil environment [...] Read more.
Ecosystems are frequently disturbed by fires that have an important impact on the soil environment and the composition of soil organisms. In order to provide a baseline for the current research and identify trends on the effects of wildland fire on soil environment and biological changes, the available literature was identified from the Web of Science database, covering the period from 1998/1998/1999 (the year of the earliest publication in this field) to 2023. A bibliometric analysis was performed and the data were visually displayed for the number of publications, countries, authors, research institutions, and keywords representing research hotspots. Specifically, the effects of wildland fire on the soil environment, on soil microorganisms and on soil fauna were analyzed. The results show that the annual number of publications describing effects of wildland fire on the soil environment and on soil microorganisms are increasing over time, while those describing effects on soil fauna are fewer and their number remains constant. The largest number of papers originate from the United States, with the United States Department of Agriculture as the research institution with the largest output. The three authors with the largest number of publications are Stefan H. Doerr, Manuel Esteban Lucas-Borja and Jan Jacob Keizer. The research hotspots, as identified by keywords, are highly concentrated on wildfire, fire, organic matter, and biodiversity, amongst others. This study comprehensively analyzes the current situation of the research on the effects of wildland fire on changes in the soil environment and organisms, and provides reference for relevant scientific researchers in this trend and future research hotspots. Full article
(This article belongs to the Special Issue Effects of Fires on Forest Ecosystems)
18 pages, 1298 KiB  
Article
Position Correction Control of Permanent-Magnet Brushless Motor Based on Commutation-Interval Current Symmetry
by Yongwu Guo, Yun Zhang and Xiaowei Li
World Electr. Veh. J. 2024, 15(5), 203; https://doi.org/10.3390/wevj15050203 (registering DOI) - 07 May 2024
Abstract
With the needs of environmental protection and the adjustment of energy structure, new energy vehicles are playing an increasingly important role in the field of transportation today. The permanent-magnet brushless direct-current motor has the characteristics of high efficiency, and can be used in [...] Read more.
With the needs of environmental protection and the adjustment of energy structure, new energy vehicles are playing an increasingly important role in the field of transportation today. The permanent-magnet brushless direct-current motor has the characteristics of high efficiency, and can be used in the drive system of new energy vehicles or other auxiliary equipment. In the control process of the permanent-magnet brushless direct-current motor, based on a three-Hall position sensor, due to various factors, there are some errors in the Hall position signal, which must be corrected by appropriate measures. In this paper, the relationship between the position deviation in the commutation interval and the non-commutation-phase current is analyzed, and the current expressions in three different states are given. A new closed-loop compensation strategy for correcting the inaccurate commutation caused by the Hall signal error is proposed. Taking the position of a 30° electrical angle before and after the phase-change point as the H point, realizing the current symmetry within the 30° interval around the H point as the target and the sum of the slopes of the tangent lines at the two points symmetrical within the β (0 < β < 30) electrical angle around the H point as the deviation, a proportional-integral regulator is designed to correct the phase error of the phase-change signal. Finally, it is verified by experiments that the closed-loop compensation strategy proposed in this paper can effectively compensate the phase deviation of the commutation signal at a speed of about 2000 r/min, which improves the working efficiency of the motor to a certain extent. Full article
11 pages, 448 KiB  
Article
Insights from Chilean NCDs Hospitalization Data during COVID-19
by Jaime Andrés Vásquez-Gómez and Chiara Saracini
Medicina 2024, 60(5), 770; https://doi.org/10.3390/medicina60050770 (registering DOI) - 07 May 2024
Abstract
The COVID-19 pandemic has affected the lifestyles of people of all ages, conditions and occupations. Social distance, remote working, changes in diet and a lack of physical activity have directly and indirectly affected many aspects of mental and physical health, particularly in patients [...] Read more.
The COVID-19 pandemic has affected the lifestyles of people of all ages, conditions and occupations. Social distance, remote working, changes in diet and a lack of physical activity have directly and indirectly affected many aspects of mental and physical health, particularly in patients with many comorbidities and non-communicable diseases (NCDs). In our paper, we analyzed COVID-19 hospitalized and non-hospitalized cases according to comorbidities to assess the average monthly percentage change (AMPC) and monthly percentage change (MPC) using open access data from the Chilean Ministry of Science, Technology, Knowledge and Innovation. As expected, the infection mainly affected patients with comorbidities, including cardiovascular risk factors. The hospitalized cases with obesity and chronic lung disease increased throughout the period of June 2020–August 2021 (AMPC = ↑20.8 and ↑19.4%, respectively, p < 0.05), as did all the non-hospitalized cases with comorbidities throughout the period (AMPC = ↑15.6 to ↑30.3 [p < 0.05]). The increases in hospitalizations and non-hospitalizations with comorbidities may be associated with physical inactivity. A healthy lifestyle with regular physical activity may have had a protective effect on the COVID-19 severity and related events in the post-pandemic period, especially for the NCD population. Full article
(This article belongs to the Special Issue Impact on Human Health, Lifestyle and Quality of Care after COVID-19)
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15 pages, 846 KiB  
Article
Quality-of-Life Assessment in Children with Mild to Moderate Bronchial Asthma
by Agnė Čibirkaitė, Vilija Bubnaitienė, Edita Hansted, Vaidotas Gurskis and Laimutė Vaidelienė
Medicina 2024, 60(5), 771; https://doi.org/10.3390/medicina60050771 (registering DOI) - 07 May 2024
Abstract
Background and Objectives: Assess the quality of life of children aged 2–10 with mild to moderate bronchial asthma. To evaluate the general health condition of children with mild and moderate severity bronchial asthma. To determine health changes in children with mild- and moderate-severity [...] Read more.
Background and Objectives: Assess the quality of life of children aged 2–10 with mild to moderate bronchial asthma. To evaluate the general health condition of children with mild and moderate severity bronchial asthma. To determine health changes in children with mild- and moderate-severity bronchial asthma as they grow older. To evaluate the impact of mild- and moderate-severity bronchial asthma on children’s daily and social activities, physical health, emotional state, and general well-being. Materials and Methods: A comparative cross-sectional study was conducted in March–June 2020. Parents or guardians of 2–10-year-old children without bronchial asthma and children with mild to moderate bronchial asthma were interviewed after receiving their written informed consent. The questionnaire was based on the standardized quality-of-life quiz SF-36. A total of 248 questionnaires were collected—106 from the parents or guardians of children with bronchial asthma and 142 from parents/guardians of children without bronchial asthma. For further analysis, 106 children without bronchial asthma and with no chronic conditions were selected. Quantitative variables were compared using the Mann–Whitney U test and qualitative data using the chi-square (χ2) criteria. Quantitative data were described by giving means, medians, and standard deviations (SD); qualitative features by giving relative frequencies. Statistical data were analyzed using SPSS and Excel 2020. Results: Children with mild and moderate asthma exhibit poorer health compared to their healthy counterparts. Only 20.7% of respondents with asthma reported excellent or very good health, contrasting with 64.1% of healthy children (p < 0.001). As children with asthma age, their general condition improves, with 46.2% showing improvement in the past year, while 42.5% of healthy children had a stable condition (p < 0.05). In various activities, children with asthma face more constraints than healthy children (p < 0.05), including energetic activities (sick—59.5%; healthy—10.3%), moderate activities (sick—24.5%; healthy—4.7%), climbing stairs (sick—22.7%; healthy—3.8%), and walking over 100 m (sick—9.4%; healthy—0%). Children with asthma are more likely to experience exhaustion, anxiety, tiredness, lack of energy, and restraint in public activities (p < 0.05). Conclusions: Parents/caregivers of children with mild to moderate bronchial asthma rate their health worse than those of healthy children do. As children with mild to moderate bronchial asthma grow, the disease impact on their overall well-being decreases. Children with mild to moderate bronchial asthma, compared to healthy children, experience more limitations in vigorous or moderate activities; face more difficulties climbing stairs or walking more than 100 m; frequently feel exhaustion, anxiety, fatigue, or lack of energy; and encounter restrictions in social activities. Full article
(This article belongs to the Section Pulmonary)
21 pages, 874 KiB  
Article
Adaptive Neural Control for a Class of Random Fractional-Order Multi-Agent Systems with Markov Jump Parameters and Full State Constraints
by Yuhang Yao, Jiaxin Yuan, Tao Chen, Chen Zhang and Hui Yang
Fractal Fract. 2024, 8(5), 278; https://doi.org/10.3390/fractalfract8050278 (registering DOI) - 07 May 2024
Abstract
Based on an adaptive neural control scheme, this paper investigates the consensus problem of random Markov jump multi-agent systems with full state constraints. Each agent is described by the fractional-order random nonlinear uncertain system driven by random differential equations, where the random noise [...] Read more.
Based on an adaptive neural control scheme, this paper investigates the consensus problem of random Markov jump multi-agent systems with full state constraints. Each agent is described by the fractional-order random nonlinear uncertain system driven by random differential equations, where the random noise is the second-order stationary stochastic process. First, in order to deal with the unknown functions with Markov jump parameters, a radial basis function neural network (RBFNN) structure is introduced to achieve approximation. Second, for the purpose of keeping the agents’ states from violating the constraint boundary, the tan-type barrier Lyapunov function is employed. By using the stochastic stability theory and adopting the backstepping technique, a novel adaptive neural control design method is presented. Furthermore, to cope with the differential explosion problem in the design course, the extended state observer (ESO) is developed instead of neural network (NN) approximation or command filtering techniques. Finally, the exponentially noise-to-state stability in the mean square is analyzed rigorously by the Lyapunov method, which guarantees the consensus of the considered multi-agent systems and all the agents’ outputs are bounded in probability. Two simulation examples are provided to verify the effectiveness of the suggested control strategy. Full article
14 pages, 4923 KiB  
Article
Is There Safety Outside the “Safe Zone” in Total Hip Replacement? A Retrospective Observational Study
by Piotr Stępiński, Dawid Jegierski, Grzegorz Maciąg, Bartosz Maciąg, Olga Adamska and Artur Stolarczyk
Medicina 2024, 60(5), 772; https://doi.org/10.3390/medicina60050772 (registering DOI) - 07 May 2024
Abstract
Background and Objectives: The safe zone in total hip replacement was introduced many years ago. Its aim was to provide guidelines for orthopedic surgeons in order to avoid complications such as instability. With the growing interest in spinopelvic alignment, some new insights [...] Read more.
Background and Objectives: The safe zone in total hip replacement was introduced many years ago. Its aim was to provide guidelines for orthopedic surgeons in order to avoid complications such as instability. With the growing interest in spinopelvic alignment, some new insights suggest that the safe zone is an obsolete concept. This study aims to show that, even outside the safe zone, the effect of total hip replacement can be satisfactory. This could be used as preliminary study for an analysis of a larger group. Materials and Methods: Fifty-nine consecutive patients with end-stage osteoarthritis treated by total hip replacement were enrolled into the study and divided into two groups: inside the safe zone and outside the safe zone. A physical examination during postoperative visits was performed; the range of movement was measured using a goniometer; and the HHS and VAS were taken to measure functional outcomes and pain, respectively. An analysis of the radiological outcomes was performed. Results: There was no significant difference in regard to changes in total offset, pain, HHS and other complications. There were no signs of instability among patients during the follow-up. Conclusions: The results of this study show that the “safe zone” is a more complicated term that was previously thought. A proper soft tissue balance and spinopelvic alignment could be factors that change the “safe zone” for each patient and make it more individual. Full article
(This article belongs to the Section Orthopedics)
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19 pages, 462 KiB  
Article
The Impact of Deficit Irrigation on the Agronomic Performance and Chemical Composition of Scolymus hispanicus L.
by Nikolaos Polyzos, Beatriz H. Paschoalinotto, Tânia C. S. P. Pires, Mikel Añibarro-Ortega, Ricardo Calhelha, Isabel C. F. R. Ferreira, Maria Inês Dias, Lillian Barros and Spyridon A. Petropoulos
Horticulturae 2024, 10(5), 479; https://doi.org/10.3390/horticulturae10050479 (registering DOI) - 07 May 2024
Abstract
In the current study, the effects of drought stress on the growth and phytochemical profile of Scolymus hispanicus L. (a.k.a. golden thistle) were evaluated. Plants were treated with three irrigation regimes, e.g., plants that received only rainwater (Control; C), deficit irrigation (I1; 50% [...] Read more.
In the current study, the effects of drought stress on the growth and phytochemical profile of Scolymus hispanicus L. (a.k.a. golden thistle) were evaluated. Plants were treated with three irrigation regimes, e.g., plants that received only rainwater (Control; C), deficit irrigation (I1; 50% of field capacity (FC)), and full irrigation (Ι2; 100% of FC). The fresh weight of the rosette of leaves was not negatively impacted by deficit irrigation, whereas root development was severely restrained compared to control and I2 treatments. Drought stress conditions had a positive effect on the nutritional properties of the golden thistle since the treatments of control and deficit irrigation showed the highest content of macronutrients and energy. Oxalic acid was the richest organic acid, especially under the I1 regime. Similarly, α-tocopherol was the only identified vitamin E isoform, whose content was also doubled in I1 treatment. Raffinose, glucose, and sucrose were the most abundant free sugars in amounts that varied among the irrigation treatments, while the total and distinct free sugar content was the highest for the I1 treatment. The most abundant detected fatty acid compounds were α-linolenic acid, followed by palmitic and linoleic acid, with the highest amount being detected in C, I1, and I2 treatments, respectively. Flavonoids were the only class of polyphenols detected in golden thistle leaves, including mostly kaempferol and quercetin derivatives. The greatest antioxidant potency was shown for the control and I1 treatments (for OxHLIA and TBARS methods, respectively). The evaluated leaf samples recorded a varied antimicrobial effect for the different bacterial strains and fungi, whereas no cytotoxic, hepatotoxic, and anti-inflammatory effects against the tested cell lines were recorded. Finally, the mineral content of leaves was significantly affected by the irrigation regime, with Ca, Mg, Cu, and Zn being the highest for the I1 treatment, while the I2 treatment had the highest content of K, Fe, and Mn and the lowest Na content. In conclusion, deficit irrigation showed promising results since it improved the phytochemical content without compromising the fresh weight of leaves, and thus it could be suggested as a sustainable agronomic practice for producing high-added value products without significant constraints in growth development and yield parameters of golden thistle. Full article
(This article belongs to the Special Issue Horticultural Production under Drought Stress)
23 pages, 1550 KiB  
Article
CAN Interface Insights for Electric Vehicle Battery Recycling
by Tero Niemi, Tero Kaarlela, Emilia Niittyviita, Ulla Lassi and Juha Röning
Batteries 2024, 10(5), 158; https://doi.org/10.3390/batteries10050158 (registering DOI) - 07 May 2024
Abstract
Road transportation is a significant worldwide contributor to greenhouse gases, and electrifying the driveline of road vehicles is essential in overcoming the evident challenge of climate change. A sustainable transition to electric vehicles requires efficient and safe methods for recycling and repurposing used [...] Read more.
Road transportation is a significant worldwide contributor to greenhouse gases, and electrifying the driveline of road vehicles is essential in overcoming the evident challenge of climate change. A sustainable transition to electric vehicles requires efficient and safe methods for recycling and repurposing used electric vehicle batteries. While various testing methods have been explored for assessing battery state of health and state of risk for recycling and reuse, a research gap exists concerning using data from integrated battery monitoring systems in the recycling process of electric vehicle batteries. This study addresses the research gap by presenting an approach to extract data from the monitoring system integrated into the battery using the automotive standard controller area network interface. In addition, methods to use this interface to ensure the optimal state of charge of the batteries for storage are presented. The benefits, challenges, and limitations set by the proprietary nature of the data to assess the state of risk and health of electric vehicle batteries for recycling and repurposing are presented, discussed, and evaluated. Finally, the influence of battery regulations and the battery passport proposal on electric vehicle battery recycling and repurposing are discussed to provide future perspectives. Full article
(This article belongs to the Section Battery Processing, Manufacturing and Recycling)
25 pages, 10696 KiB  
Article
Day-to-Night Street View Image Generation for 24-Hour Urban Scene Auditing Using Generative AI
by Zhiyi Liu, Tingting Li, Tianyi Ren, Da Chen, Wenjing Li and Waishan Qiu
J. Imaging 2024, 10(5), 112; https://doi.org/10.3390/jimaging10050112 (registering DOI) - 07 May 2024
Abstract
A smarter city should be a safer city. Nighttime safety in metropolitan areas has long been a global concern, particularly for large cities with diverse demographics and intricate urban forms, whose citizens are often threatened by higher street-level crime rates. However, due to [...] Read more.
A smarter city should be a safer city. Nighttime safety in metropolitan areas has long been a global concern, particularly for large cities with diverse demographics and intricate urban forms, whose citizens are often threatened by higher street-level crime rates. However, due to the lack of night-time urban appearance data, prior studies based on street view imagery (SVI) rarely addressed the perceived night-time safety issue, which can generate important implications for crime prevention. This study hypothesizes that night-time SVI can be effectively generated from widely existing daytime SVIs using generative AI (GenAI). To test the hypothesis, this study first collects pairwise day-and-night SVIs across four cities diverged in urban landscapes to construct a comprehensive day-and-night SVI dataset. It then trains and validates a day-to-night (D2N) model with fine-tuned brightness adjustment, effectively transforming daytime SVIs to nighttime ones for distinct urban forms tailored for urban scene perception studies. Our findings indicate that: (1) the performance of D2N transformation varies significantly by urban-scape variations related to urban density; (2) the proportion of building and sky views are important determinants of transformation accuracy; (3) within prevailed models, CycleGAN maintains the consistency of D2N scene conversion, but requires abundant data. Pix2Pix achieves considerable accuracy when pairwise day–and–night-night SVIs are available and are sensitive to data quality. StableDiffusion yields high-quality images with expensive training costs. Therefore, CycleGAN is most effective in balancing the accuracy, data requirement, and cost. This study contributes to urban scene studies by constructing a first-of-its-kind D2N dataset consisting of pairwise day-and-night SVIs across various urban forms. The D2N generator will provide a cornerstone for future urban studies that heavily utilize SVIs to audit urban environments. Full article
(This article belongs to the Special Issue Visual Localization—Volume II)
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14 pages, 31971 KiB  
Article
The Computational Investigation of the Mechanical Response of a Bioinspired Nacre-like Nanocomposite under Three-Point Bending
by Xingzi Yang, Md Jalal Uddin Rumi and Xiaowei Zeng
J. Compos. Sci. 2024, 8(5), 173; https://doi.org/10.3390/jcs8050173 (registering DOI) - 07 May 2024
Abstract
Natural biological nanocomposites, like nacre, demonstrate extraordinary fracture toughness, surpassing their base materials, attributed to their intricate staggered hierarchical architectures integrating hard and soft phases. The enhancement of toughness in these composites is often linked to the crack-deflection mechanism. Leveraging the core design [...] Read more.
Natural biological nanocomposites, like nacre, demonstrate extraordinary fracture toughness, surpassing their base materials, attributed to their intricate staggered hierarchical architectures integrating hard and soft phases. The enhancement of toughness in these composites is often linked to the crack-deflection mechanism. Leveraging the core design principles that enhance durability, resilience, and robustness in organic materials, this paper describes the use of computational modeling and simulation to perform a three-point bending test on a 3D staggered nanocomposite intentionally crafted to mimic the detailed microstructure of nacre. We adopted a previously proposed interfacial zone model that conceptualizes the “relatively soft” layer as an interface between the “hard” mineral tablets and the microstructure’s interlayer spaces to examine how the microstructure and interface characteristics affect the mechanical responses and failure mechanisms. By comparing the model’s predictions with experimental data on natural nacre, the simulations unveil the mechanisms of tablet separation through adjacent layer sliding and crack deflection across interfacial zones. This study offers a robust numerical method for investigating the fracture toughening mechanisms and damage evolution and contributes to a deeper understanding of the complex interplays within biomimetic materials. Full article
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16 pages, 1711 KiB  
Article
Wood Distillate Mitigates Ozone-Induced Visible and Photosynthetic Plant Damage: Evidence from Ozone-Sensitive Tobacco (Nicotiana tabacum L.) BelW3
by Andrea Vannini and Alessandro Petraglia
Horticulturae 2024, 10(5), 480; https://doi.org/10.3390/horticulturae10050480 (registering DOI) - 07 May 2024
Abstract
The use of wood distillate (WD) is emerging as a valuable strategy for protecting horticultural crops from the oxidizing effects of ozone (O3). To fully understand its effectiveness, extensive testing on different plant species is needed. As a viable interim measure, [...] Read more.
The use of wood distillate (WD) is emerging as a valuable strategy for protecting horticultural crops from the oxidizing effects of ozone (O3). To fully understand its effectiveness, extensive testing on different plant species is needed. As a viable interim measure, an assessment of WD efficacy in model plants can be made until species-specific results become available. The aim of this study is to evaluate the ability of WD derived from chestnut wood (Castanea sativa Mill.) to protect the ozone-sensitive tobacco plant (Nicotiana tabacum L.) BelW3 from the oxidizing effects of O3, using the ozone-resistant tobacco plant BelB as benchmark. The protective effect was evaluated during treatment applications and three weeks after these were completed. Ten BelW3 and five BelB plants were grown just outside Parma from June to October 2023, a period when average maximum O3 concentrations were at least 120 ppb. Starting from July, five BelW3 plants were sprayed weekly with WD at 0.2% for two months. Morphometric and photosynthetic measurements were then taken after six and 11 weeks from the beginning of treatments and three weeks after the end to assess protection persistence (if any). BelW3 showed a significant effect of O3 compared to BelB plants for both morphometric and photosynthetic measurements, exhibiting increased necrotic areas on the leaf blade, reduced number of viable leaves, reduced average plant height, together with reduced chlorophyll content and impaired photosynthetic system functionality. BelW3 plants also showed a significant decrease in the efficiency of parameters related to PSII and PSI when compared to BelB. Wood distillate application, however, successfully mitigated O3 effects on BelW3, as revealed by morphometric and photosynthetic values, which were in line with those observed in BelB. Notably, WD protective effect persisted 3 weeks after treatment cessation, highlighting the short-term protective capacity of the distillate against the oxidative action of O3. Full article
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20 pages, 5088 KiB  
Article
Building Information Modeling/Building Energy Simulation Integration Based on Quantitative and Interpretative Interoperability Analysis
by Carolina Fernandes Vaz, Luísa Lopes de Freitas Guilherme, Ana Carolina Fernandes Maciel, André Luis De Araujo, Bruno Barzellay Ferreira Da Costa and Assed Naked Haddad
Infrastructures 2024, 9(5), 84; https://doi.org/10.3390/infrastructures9050084 (registering DOI) - 07 May 2024
Abstract
The integration between the building information modeling (BIM) methodology and the building energy simulation (BES) can contribute to a thermo-energetic analysis since the model generated and fed into BIM is exported to simulation software. This integration, also called interoperability, is satisfactory when the [...] Read more.
The integration between the building information modeling (BIM) methodology and the building energy simulation (BES) can contribute to a thermo-energetic analysis since the model generated and fed into BIM is exported to simulation software. This integration, also called interoperability, is satisfactory when the information flow is carried out without the loss of essential information. Several studies point out interoperability flaws between the methodologies; however, most of them occur in low-geometry-complexity models during quantitative experiments. The purpose of this research was to analyze the BIM/BES integration based on a quantitative and interpretative interoperability analysis of two buildings with complex geometries located on the UFU Campus (library and Building 5T) in Uberlândia, Brazil. To accomplish this, two geometries of each building were modeled, detailed, and simplified to analyze the data import, workflow, and model correction in the BES software. In the case of the library, the integration of Revit with DesignBuilder and IES-VE was analyzed, and in Block 5T, Revit was used with DesignBuilder and eQUEST. The BES software that presented the best integration with Revit for complex geometries was DesignBuilder, with the best performance being in the interpretative criteria. It was concluded that the simplification of complex geometries is essential for better data transfers. To determine the BES software that has better integration with BIM, a comprehensive evaluation is necessary, considering not only data transfers but also ease of working within BES software, the possibility of corrections in these, as well as the availability of tutorials and developer support. Full article
(This article belongs to the Special Issue Smart, Sustainable and Resilient Infrastructures, 2nd Edition)
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17 pages, 4881 KiB  
Article
Intelligent Packet Priority Module for a Network of Unmanned Aerial Vehicles Using Manhattan Long Short-Term Memory
by Dino Budi Prakoso, Jauzak Hussaini Windiatmaja, Agus Mulyanto, Riri Fitri Sari and Rosdiadee Nordin
Drones 2024, 8(5), 183; https://doi.org/10.3390/drones8050183 (registering DOI) - 07 May 2024
Abstract
Unmanned aerial vehicles (UAVs) are becoming more common in wireless communication networks. Using UAVs can lead to network problems. An issue arises when the UAVs function in a network-access-limited environment with nodes causing interference. This issue could potentially hinder UAV network connectivity. This [...] Read more.
Unmanned aerial vehicles (UAVs) are becoming more common in wireless communication networks. Using UAVs can lead to network problems. An issue arises when the UAVs function in a network-access-limited environment with nodes causing interference. This issue could potentially hinder UAV network connectivity. This paper introduces an intelligent packet priority module (IPPM) to minimize network latency. This study analyzed Network Simulator–3 (NS-3) network modules utilizing Manhattan long short-term memory (MaLSTM) for packet classification of critical UAV, ground control station (GCS), or interfering nodes. To minimize network latency and packet delivery ratio (PDR) issues caused by interfering nodes, packets from prioritized nodes are transmitted first. Simulation results and evaluation show that our proposed intelligent packet priority module (IPPM) method outperformed previous approaches. The proposed IPPM based on MaLSTM implementation for the priority packet module led to a lower network delay and a higher packet delivery ratio. The performance of the IPPM averaged 62.2 ms network delay and 0.97 packet delivery ratio (PDR). The MaLSTM peaked at 97.5% accuracy. Upon further evaluation, the stability of LSTM Siamese models was observed to be consistent across diverse similarity functions, including cosine and Euclidean distances. Full article
(This article belongs to the Special Issue UAV-Assisted Mobile Wireless Networks and Applications)
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32 pages, 1244 KiB  
Review
A Narrative Review of the Sociotechnical Landscape and Potential of Computer-Assisted Dynamic Assessment for Children with Communication Support Needs
by Christopher S. Norrie, Stijn R. J. M. Deckers, Maartje Radstaake and Hans van Balkom
Multimodal Technol. Interact. 2024, 8(5), 38; https://doi.org/10.3390/mti8050038 (registering DOI) - 07 May 2024
Abstract
This paper presents a narrative review of the current practices in assessing learners’ cognitive abilities and the limitations of traditional intelligence tests in capturing a comprehensive understanding of a child’s learning potential. Referencing prior research, it explores the concept of dynamic assessment (DA) [...] Read more.
This paper presents a narrative review of the current practices in assessing learners’ cognitive abilities and the limitations of traditional intelligence tests in capturing a comprehensive understanding of a child’s learning potential. Referencing prior research, it explores the concept of dynamic assessment (DA) as a promising yet underutilised alternative that focuses on a child’s responsiveness to learning opportunities. The paper highlights the potential of novel technologies, in particular tangible user interfaces (TUIs), in integrating computational science with DA to improve the access and accuracy of assessment results, especially for children with communication support needs (CSN), as a catalyst for abetting critical communicative competencies. However, existing research in this area has mainly focused on the automated mediation of DA, neglecting the human element that is crucial for effective solutions in special education. A framework is proposed to address these issues, combining pedagogical and sociocultural elements alongside adaptive information technology solutions in an assessment system informed by user-centred design principles to fully support teachers/facilitators and learners with CSN within the special education ecosystem. Full article

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