The 2023 MDPI Annual Report has
been released!
 
20 pages, 300 KiB  
Article
Fixed Point Results for Compatible Mappings in Extended Parametric Sb-Metric Spaces
by Sunil Beniwal, Naveen Mani, Rahul Shukla and Amit Sharma
Mathematics 2024, 12(10), 1460; https://doi.org/10.3390/math12101460 (registering DOI) - 08 May 2024
Abstract
This study aims to establish common fixed point theorems for a pair of compatible self-mappings within the framework of extended parametric Sb-metric spaces. To support our assertions, we provide corollaries and examples accompanied with graphical representations. Moreover, we leverage our principal [...] Read more.
This study aims to establish common fixed point theorems for a pair of compatible self-mappings within the framework of extended parametric Sb-metric spaces. To support our assertions, we provide corollaries and examples accompanied with graphical representations. Moreover, we leverage our principal outcome to guarantee the existence of a common solution to a system of integral equations. Full article
(This article belongs to the Special Issue Novel Approaches in Fuzzy Sets and Metric Spaces)
21 pages, 4684 KiB  
Article
Appropriate Application of Organic Fertilizer Can Effectively Improve Soil Environment and Increase Maize Yield in Loess Plateau
by Yingying Xing, Yuan Li, Fan Zhang and Xiukang Wang
Agronomy 2024, 14(5), 993; https://doi.org/10.3390/agronomy14050993 (registering DOI) - 08 May 2024
Abstract
Fertilization has a significant impact on soil nutrients and microbiological properties, which, in turn, affect crop yield. However, the specific effects of organic and inorganic fertilizers on soil fertility and microbial characteristics in maize fields, as well as the key soil factors influencing [...] Read more.
Fertilization has a significant impact on soil nutrients and microbiological properties, which, in turn, affect crop yield. However, the specific effects of organic and inorganic fertilizers on soil fertility and microbial characteristics in maize fields, as well as the key soil factors influencing changes in crop yield, remain largely unknown. A study was conducted over two years (2021–2022) to investigate the impact of various nitrogen fertilization rates and types on maize yield and soil properties in the Loess Plateau. Field experiments with five nitrogen levels (60, 90, 120, 150, and 180 kg N ha−1) and two fertilizer types (chemical and organic) were conducted. The optimal yield was achieved with 150 kg N ha−1, significantly surpassing that of other treatments by 4.5−45.7%. Compared with the organic fertilizers, the chemical fertilizers increased soil salt and catalase levels, with soil nitrate and ammonium content being higher at the jointing stage but lower at maturity. Organic fertilization improved soil potassium, organic matter, urease and phosphatase activities, and microbial populations. Yield correlated with several soil indicators, including salt content, nitrate, available potassium, and enzyme activities. Notably, soil nitrate also correlated with actinomyces quantity. A principal component analysis showed that the organic fertilizer was more beneficial to soil health than the chemical fertilizer. Consequently, this study recommends 150 kg N ha−1 of organic fertilizer for sustainable maize farming and soil health in China’s northwest arid region, providing a theoretical framework for agricultural practices. Full article
(This article belongs to the Section Agroecology Innovation: Achieving System Resilience)
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12 pages, 473 KiB  
Review
Telerehabilitation in Children and Adolescents with Cystic Fibrosis: A Scoping Review
by Ezequiel Pessoa, Mara Ferreira and Cristina Lavareda Baixinho
Healthcare 2024, 12(10), 971; https://doi.org/10.3390/healthcare12100971 (registering DOI) - 08 May 2024
Abstract
Cystic fibrosis requires regular monitoring and intervention by healthcare teams; despite that, adherence to therapeutic measures is less than desired. The evolution of technology has allowed much of the care provided in person to be replaced by a telehealth delivery model, but studies [...] Read more.
Cystic fibrosis requires regular monitoring and intervention by healthcare teams; despite that, adherence to therapeutic measures is less than desired. The evolution of technology has allowed much of the care provided in person to be replaced by a telehealth delivery model, but studies on telerehabilitation are scarce and dispersed. This scoping review aimed to identify which domains of rehabilitation intervention are mediated by information and communication technologies and how they are developed in the provision of care to children and adolescents with cystic fibrosis. The data collection was conducted in February and June 2023, following the three steps recommended by the JBI for this type of review: (1) the search was conducted in MEDLINE, CINAHL, Scopus, JBI, and Web of Science; (2) the bibliographic references obtained from the included articles were analysed; and (3) the grey literature was checked. The eligibility criteria were children and adolescents and rehabilitation interventions mediated by information and communication technologies. The five studies included in this review were subjected to analysis, and a narrative synthesis of the results was carried out. The interventions identified included physical exercise programs (60%), management of the therapeutic regimen (40%), and symptom control (40%). The information and communication technologies were web-based platforms, video games, and telephones. The use of telerehabilitation included face-to-face meetings to ensure participants performed the exercises correctly, monitor their response to exercise, and teach them how to avoid risky situations during home workouts. In all studies, exercise sessions were supervised by the participants’ parents or caregivers. Full article
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19 pages, 2095 KiB  
Article
Tight or Loose: Analysis of the Organization Cognition Process of Epidemic Risk and Policy Selection
by Chao Fan, Yue Zhuang and Yangyang Qian
Sustainability 2024, 16(10), 3949; https://doi.org/10.3390/su16103949 (registering DOI) - 08 May 2024
Abstract
In the context of Disease X risks, how governments and public health authorities make policy choices in response to potential epidemics has become a topic of increasing concern. The tightness of epidemic prevention policies is related to the effectiveness of the implementation of [...] Read more.
In the context of Disease X risks, how governments and public health authorities make policy choices in response to potential epidemics has become a topic of increasing concern. The tightness of epidemic prevention policies is related to the effectiveness of the implementation of measures, while the organizational cognition of epidemic risks is related to the rationality of policy choices. During the three years of COVID-19, the Chinese government constantly adjusted the tightness of its prevention policies as awareness of the epidemic risk improved. Therefore, based on the epidemic risk organizational cognition model, the key nodes that affect the tightness of epidemic prevention policies can be explored to find the organizational behavior rules behind the selection of prevention policies. Firstly, through observing the adjustments made to the Chinese government’s prevention strategies during the epidemic, a time-series cross-case comparative analysis reveals how policy tightness shifted from stringent to lenient. This shift coincided with the organizational cognition of epidemic risk evolving from vague to clear. Secondly, by building the “knowledge-cognition” coordinate system to draw the organizational cognition spiral of epidemic risk, it is clear that the changes in the tightness of the prevention policies mainly came from the internalization and externalization of knowledge such as epidemic risk characteristics to promote the level of organizational cognition, which is manifested as expansion and deepening. Thirdly, the node changes in the interaction between organizational cognition development and policy choice proved that different stages of the epidemic had diverse environmental parameters. Moreover, as the epidemic nears its end, the focus of policy tightness is shifting from policy objectives to policy implementation around governance tools. The results indicate that organizational cognition of epidemic risk exhibits significant stages and periodicity. Additionally, epidemic risk characteristics, environmental coupling, and governance tools are crucial factors in determining the tightness of epidemic prevention policies. Full article
(This article belongs to the Section Hazards and Sustainability)
20 pages, 8555 KiB  
Article
Synergistic Effects of Humic Acid, Biochar-Based Microbial Agent, and Vermicompost on the Dry Sowing and Wet Emergence Technology of Cotton in Saline–Alkali Soils, Xinjiang, China
by Ge Li, Yuyang Shan, Yungang Bai, Weibo Nie, Qian Wang, Jianghui Zhang, Hongbo Liu, Yu Ding, Xiaoyan Wang and Hongqin Lu
Agronomy 2024, 14(5), 994; https://doi.org/10.3390/agronomy14050994 (registering DOI) - 08 May 2024
Abstract
Soil amendments such as humic acid (HA), a biochar-based microbial agent (M), and vermicompost (V) can improve soil quality and promote crop growth. However, it remains unclear whether the co-application of the three soil amendments (HMV) has a synergistic effect on alleviating soil [...] Read more.
Soil amendments such as humic acid (HA), a biochar-based microbial agent (M), and vermicompost (V) can improve soil quality and promote crop growth. However, it remains unclear whether the co-application of the three soil amendments (HMV) has a synergistic effect on alleviating soil quality deterioration obstacles caused by dry sowing and wet emergence technology in Xinjiang cotton fields. A three-year field experiment was conducted in saline–alkali soils using plastic-film-mulched drip irrigation in Xinjiang, China. Through the orthogonal experiment method, the application amounts of HA, M and V were 75 kg ha−1, 75 kg ha−1 and 225 kg ha−1 respectively in 2021. In 2022, three application amount gradients were used for HA, M and V: 60 kg ha−1, 90 kg ha−1 and 120 kg ha−1 respectively. In 2023, the application amounts of HA, M, and V were 60 kg ha−1, 120 kg ha−1, and 120 kg ha−1. It should be pointed out that V contains HA in the range of 20–35%. This study aimed to explore the improvement effect of a single or combined application of HA, M, and V on soil quality and cotton emergence rate using dry sowing and wet emergence technology in Xinjiang cotton fields. The results showed that the single and combined applications of HA, M, and V improved the soil quality and water–heat–salt environment of the cultivated layer. In the combined application, the cotton seedling emergence rate and yield increased by 1.9–22.8% and 7.0–54.1%. Therefore, it is recommended to jointly apply HA, M, and V to promote cotton seedling emergence and increase yield using dry sowing and wet emergence technology in Xinjiang cotton fields. Full article
(This article belongs to the Section Agricultural Biosystem and Biological Engineering)
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18 pages, 505 KiB  
Article
GlycA and CRP Are Genetically Correlated: Insight into the Genetic Architecture of Inflammageing
by Melody Kasher, Maxim B. Freidin, Frances M. K. Williams, Gregory Livshits and CHARGE Inflammation Working Group
Biomolecules 2024, 14(5), 563; https://doi.org/10.3390/biom14050563 (registering DOI) - 08 May 2024
Abstract
Inflammageing is a condition of perpetual low-grade inflammation induced by ageing. Inflammageing may be predicted by the C-reactive protein (CRP) or by a recently described biomarker which measures N-glycosylated side chains of the carbohydrate component of several acute-phase proteins known as GlycA. The [...] Read more.
Inflammageing is a condition of perpetual low-grade inflammation induced by ageing. Inflammageing may be predicted by the C-reactive protein (CRP) or by a recently described biomarker which measures N-glycosylated side chains of the carbohydrate component of several acute-phase proteins known as GlycA. The objective of this study was to examine in depth the genetic relationships between CRP and GlycA as well as between each of them and other selected cytokines, which may shed light on the mechanisms of inflammageing. Using the Olink 96 Inflammation panel, data on inflammatory mediators for 1518 twins from the TwinsUK dataset were acquired. Summary statistics for genome-wide association studies for several cytokines as well as CRP and GlycA were collected from public sources. Extensive genetic correlation analyses, colocalization and genetic enrichment analyses were carried out to detect the shared genetic architecture between GlycA and CRP. Mendelian randomization was carried out to assess potential causal relationships. GlycA predicted examined cytokines with a magnitude twice as great as that of CRP. GlycA and CRP were significantly genetically correlated (Rg = 0.4397 ± 0.0854, p-value = 2.60 × 10−7). No evidence of a causal relationship between GlycA and CRP, or between these two biomarkers and the cytokines assessed was obtained. However, the aforementioned relationships were explained well by horizontal pleiotropy. Five exonic genetic variants annotated to five genes explain the shared genetic architecture observed between GlycA and CRP: IL6R, GCKR, MLXIPL, SERPINA1, and MAP1A. GlycA and CRP possess a shared genetic architecture, but the relationship between them appears to be modest, which may imply the promotion of differing inflammatory pathways. GlycA appears to be a more robust predictor of cytokines compared to CRP. Full article
15 pages, 5983 KiB  
Article
Enhancing the Thermal Resistance of UV-Curable Resin Using (3-Thiopropyl)polysilsesquioxane
by Daria Pakuła, Bogna Sztorch, Monika Topa-Skwarczyńska, Karolina Gałuszka, Joanna Ortyl, Bogdan Marciniec and Robert E. Przekop
Materials 2024, 17(10), 2219; https://doi.org/10.3390/ma17102219 (registering DOI) - 08 May 2024
Abstract
This study delineates a methodology for the preparation of new composites based on a photocurable urethane-acrylate resin, which has been modified with (3-thiopropyl)polysilsesquioxane (SSQ-SH). The organosilicon compound combines fully enclosed cage structures and incompletely condensed silanols (a mixture of random structures) obtained through [...] Read more.
This study delineates a methodology for the preparation of new composites based on a photocurable urethane-acrylate resin, which has been modified with (3-thiopropyl)polysilsesquioxane (SSQ-SH). The organosilicon compound combines fully enclosed cage structures and incompletely condensed silanols (a mixture of random structures) obtained through the hydrolytic condensation of (3-mercaptopropyl)trimethoxysilane. This process involves a thiol-ene “click” reaction between SSQ-SH and a commercially available resin (Ebecryl 1271®) in the presence of the photoinitiator DMPA, resulting in composites with significantly changed thermal properties. Various tests were conducted, including thermogravimetric analysis (TGA), Fourier transmittance infrared spectroscopy (FT-IR), differential scanning calorimetry (Photo-DSC), and photoreological measurement mechanical property, and water contact angle (WCA) tests. The modification of resin with SSQ-SH increased the temperature of 1% and 5% mass loss compared to the reference (for 50 wt% SSQ-SH, T5% was 310.8 °C, an increase of 20.4 °C). A composition containing 50 wt% of SSQ-SH crosslinked faster than the reference resin, a phenomenon confirmed by photorheological tests. This research highlights the potential of new composite materials in coating applications across diverse industries. The modification of resin with SSQ-SH not only enhances thermal properties but also introduces a host of functional improvements, thereby elevating the performance of the resulting coatings. Full article
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17 pages, 2723 KiB  
Systematic Review
Reconstruction of Partial Hypopharyngeal Defects following Total Laryngectomy: A Systematic Review and Meta-Analysis
by Anthony M. Tonsbeek, Roxy Leidelmeijer, Caroline A. Hundepool, Liron S. Duraku, Mark J. W. Van der Oest, Aniel Sewnaik and Marc A. M. Mureau
Cancers 2024, 16(10), 1804; https://doi.org/10.3390/cancers16101804 (registering DOI) - 08 May 2024
Abstract
Background: Various operative techniques exist to reconstruct partial hypopharyngeal defects following total laryngectomy. The current study aimed to investigate and compare complications and functional results following commonly used reconstructive techniques. Methods: A systematic review and meta-analysis were performed using studies that investigated outcomes [...] Read more.
Background: Various operative techniques exist to reconstruct partial hypopharyngeal defects following total laryngectomy. The current study aimed to investigate and compare complications and functional results following commonly used reconstructive techniques. Methods: A systematic review and meta-analysis were performed using studies that investigated outcomes after the reconstruction of a partial hypopharyngeal defect. The outcomes of interest were fistulas, strictures, flap failure, swallowing function and postoperative speech. Results: Of the 4035 studies identified, 23 were included in this review. Four common reconstructive techniques were reported, with a total of 794 patients: (1) pectoralis major myocutaneous and (2) myofascial flap, (3) anterolateral thigh free flap and (4) radial forearm free flap. Fistulas occurred significantly more often than pectoralis major myocutaneous flaps (34%, 95% CI 23–47%) compared with other flaps (p < 0.001). No significant differences in the rates of strictures or flap failure were observed. Pectoralis major myofascial flaps were non-inferior to free-flap reconstructions. Insufficient data were available to assess speech results between flap types. Conclusion: Pectoralis myocutaneous flaps should not be the preferred method of reconstruction for most patients, considering their significantly higher rate of fistulas. In contrast, pectoralis major myofascial flaps yield promising results compared to free-flap reconstructions, warranting further investigation. Full article
(This article belongs to the Special Issue Advances in Surgery of Head and Neck Squamous Cell Carcinoma)
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23 pages, 6888 KiB  
Article
Environmental Restoration and Changes of Sediment and Hydrodynamic Parameters in a Section of a Renaturalised Lowland Watercourse
by Stanisław Zaborowski, Tomasz Kałuża, Szymon Jusik, Tomasz Dysarz and Mateusz Hämmerling
Sustainability 2024, 16(10), 3948; https://doi.org/10.3390/su16103948 (registering DOI) - 08 May 2024
Abstract
In Europe, the routes of most watercourses were straightened and shortened, leading to the destruction and degradation of many natural environments. Currently, in places where it is possible, as part of the implementation of the Water Framework Directive, efforts are made to improve [...] Read more.
In Europe, the routes of most watercourses were straightened and shortened, leading to the destruction and degradation of many natural environments. Currently, in places where it is possible, as part of the implementation of the Water Framework Directive, efforts are made to improve environmental sustainability, including improving the ecological condition of rivers. This paper presents the impact of three in-stream deflectors on changes in the section of a small lowland river—the Flinta (Poland)—where (from 2018 to 2023) detailed, systematic geodetic, and hydrometric research and an assessment of the ecological conditions were carried out. The presented results show the influence of deflectors on the initiation of fluvial processes in the transverse and longitudinal layouts of the channel. The river channel was narrowed from 6 to 5 m, and the current line shifted by almost 3 m. Changes were observed in the distribution of velocities and shear stresses, varying along the surveyed section of the river. In the first year after their application, an increase in velocity at the deflectors can be observed (from 0.2 m∙s−1 to 0.6 m∙s−1 in the deflector cross-section). In the following years, on the other hand, a clear decrease in velocity was observed in the sections between the deflectors (to 0.3 m∙s−1). The introduction of deflectors resulted in a significant increase in the values of shear stresses (from an average value of 0.0241 N∙m−2 in 2018 to 0.2761 N∙m−2 in 2023) and local roughness coefficients (from 0.045 s∙m−1/3 before the introduction of the deflectors to 0.070 s∙m−1/3 in 2023). Based on analyses of sediment samples, erosion and accumulation of bottom material were initially observed, followed by a subsequent stabilisation of particle size. Differences in grain size were observed, especially in the cross-section of the deflectors (increase in granularity d50% downstream of the deflector from 0.31 mm to 3.9 mm already 2 years after the introduction of deflectors). This study confirmed the positive impact of using deflectors on hydromorphological processes as deflectors facilitate the achievement of a good ecological status, as required by the WFD. The innovation of this paper lies in demonstrating the possibility of using small, simple structures to initiate and intensify fluvial processes, which may contribute to improving the ecological conditions of watercourses. Full article
8 pages, 311 KiB  
Communication
Risk of Obstetric Anal Sphincter Injury by Delivering Provider
by Taniya V. Walker, Ciara Bryson, Sara Rahman and Charelle M. Carter-Brooks
Reprod. Med. 2024, 5(2), 57-64; https://doi.org/10.3390/reprodmed5020007 (registering DOI) - 08 May 2024
Abstract
Introduction and Hypothesis: Obstetric anal sphincter injuries (OASIs) complicate 5.8% of vaginal deliveries. Our objective was to assess if the primary delivery provider, a nurse-midwife versus physician obstetrician, is associated with OASIs. Methods: We performed a secondary analysis of the Consortium of Safe [...] Read more.
Introduction and Hypothesis: Obstetric anal sphincter injuries (OASIs) complicate 5.8% of vaginal deliveries. Our objective was to assess if the primary delivery provider, a nurse-midwife versus physician obstetrician, is associated with OASIs. Methods: We performed a secondary analysis of the Consortium of Safe Labor, a multicenter, retrospective cohort study. Included were nulliparous women with singleton, vaginal delivery at ≥37 weeks from 2002 to 2008. Women were excluded if delivery was complicated by shoulder dystocia or from sites without midwife deliveries. Student’s t-tests, chi-squared analysis, and Fisher’s exact test were used as appropriate. Multivariable logistic regression and propensity score-matching analyses were performed. Results: Of 228,668 births at 19 sites, 2735 births from 3 sites met the inclusion criteria: 1551 physician and 1184 midwife births. Of all births, 4.2% (n = 116) were complicated by OASIs. Physician patients were older, more often White, privately insured, with higher BMI, more medical co-morbidities, and labor inductions/augmentations. Midwife patients had higher fetal gestational age and infant birth weights (all p < 0.05). OASIs were more common in physician compared to midwife births (5.9% vs. 2.0%, p < 0.0001). This difference persisted in multivariable logistic regression. OASIs were 2.4 (95%CI 1.5–3.9) times more likely with physician delivery when controlling for maternal heart disease, episiotomy, increasing maternal age, decreasing maternal BMI, non-White race, and increasing birthweight. The AUC was 0.78. With propensity score matching, OASI rates remained higher amongst physician births (6.6% vs. 1.8%, p < 0.0001; aOR 3.8 (95%CI 2.0–7.1)). Conclusion: OASIs were more common in physician compared to midwife deliveries even when controlling for other associated factors. Full article
40 pages, 11431 KiB  
Article
Image-Aided LiDAR Extraction, Classification, and Characterization of Lane Markings from Mobile Mapping Data
by Yi-Ting Cheng, Young-Ha Shin, Sang-Yeop Shin, Yerassyl Koshan, Mona Hodaei, Darcy Bullock and Ayman Habib
Remote Sens. 2024, 16(10), 1668; https://doi.org/10.3390/rs16101668 (registering DOI) - 08 May 2024
Abstract
The documentation of roadway factors (such as roadway geometry, lane marking retroreflectivity/classification, and lane width) through the inventory of lane markings can reduce accidents and facilitate road safety analyses. Typically, lane marking inventory is established using either imagery or Light Detection and Ranging [...] Read more.
The documentation of roadway factors (such as roadway geometry, lane marking retroreflectivity/classification, and lane width) through the inventory of lane markings can reduce accidents and facilitate road safety analyses. Typically, lane marking inventory is established using either imagery or Light Detection and Ranging (LiDAR) data collected by mobile mapping systems (MMS). However, it is important to consider the strengths and weaknesses of both camera and LiDAR units when establishing lane marking inventory. Images may be susceptible to weather and lighting conditions, and lane marking might be obstructed by neighboring traffic. They also lack 3D and intensity information, although color information is available. On the other hand, LiDAR data are not affected by adverse weather and lighting conditions, and they have minimal occlusions. Moreover, LiDAR data provide 3D and intensity information. Considering the complementary characteristics of camera and LiDAR units, an image-aided LiDAR framework would be highly advantageous for lane marking inventory. In this context, an image-aided LiDAR framework means that the lane markings generated from one modality (i.e., either an image or LiDAR) are enhanced by those derived from the other one (i.e., either imagery or LiDAR). In addition, a reporting mechanism that can handle multi-modal datasets from different MMS sensors is necessary for the visualization of inventory results. This study proposes an image-aided LiDAR lane marking inventory framework that can handle up to five lanes per driving direction, as well as multiple imaging and LiDAR sensors onboard an MMS. The framework utilizes lane markings extracted from images to improve LiDAR-based extraction. Thereafter, intensity profiles and lane width estimates can be derived using the image-aided LiDAR lane markings. Finally, imagery/LiDAR data, intensity profiles, and lane width estimates can be visualized through a web portal that has been developed in this study. For the performance evaluation of the proposed framework, lane markings obtained through LiDAR-based, image-based, and image-aided LiDAR approaches are compared against manually established ones. The evaluation demonstrates that the proposed framework effectively compensates for the omission errors in the LiDAR-based extraction, as evidenced by an increase in the recall from 87.6% to 91.6%. Full article
22 pages, 333 KiB  
Article
Geometric Algebra Jordan–Wigner Transformation for Quantum Simulation
by Grégoire Veyrac and Zeno Toffano
Entropy 2024, 26(5), 410; https://doi.org/10.3390/e26050410 (registering DOI) - 08 May 2024
Abstract
Quantum simulation qubit models of electronic Hamiltonians rely on specific transformations in order to take into account the fermionic permutation properties of electrons. These transformations (principally the Jordan–Wigner transformation (JWT) and the Bravyi–Kitaev transformation) correspond in a quantum circuit to the introduction of [...] Read more.
Quantum simulation qubit models of electronic Hamiltonians rely on specific transformations in order to take into account the fermionic permutation properties of electrons. These transformations (principally the Jordan–Wigner transformation (JWT) and the Bravyi–Kitaev transformation) correspond in a quantum circuit to the introduction of a supplementary circuit level. In order to include the fermionic properties in a more straightforward way in quantum computations, we propose to use methods issued from Geometric Algebra (GA), which, due to its commutation properties, are well adapted for fermionic systems. First, we apply the Witt basis method in GA to reformulate the JWT in this framework and use this formulation to express various quantum gates. We then rewrite the general one and two-electron Hamiltonian and use it for building a quantum simulation circuit for the Hydrogen molecule. Finally, the quantum Ising Hamiltonian, widely used in quantum simulation, is reformulated in this framework. Full article
17 pages, 3128 KiB  
Article
New Cocrystals of Ligustrazine: Enhancing Hygroscopicity and Stability
by Yifei Xie, Lixiang Gong, Yue Tao, Baoxi Zhang, Li Zhang, Shiying Yang, Dezhi Yang, Yang Lu and Guanhua Du
Molecules 2024, 29(10), 2208; https://doi.org/10.3390/molecules29102208 (registering DOI) - 08 May 2024
Abstract
Ligustrazine (TMP) is the main active ingredient extracted from Rhizoma Chuanxiong, which is used in the treatment of cardiovascular and cerebrovascular diseases, with the drawback of being unstable and readily sublimated. Cocrystal technology is an effective method to improve the stability of [...] Read more.
Ligustrazine (TMP) is the main active ingredient extracted from Rhizoma Chuanxiong, which is used in the treatment of cardiovascular and cerebrovascular diseases, with the drawback of being unstable and readily sublimated. Cocrystal technology is an effective method to improve the stability of TMP. Three benzoic acid compounds including P-aminobenzoic acid (PABA), 3-Aminobenzoic acid (MABA), and 3,5-Dinitrobenzoic acid (DNBA) were chosen for co-crystallization with TMP. Three novel cocrystals were obtained, including TMP-PABA (1:2), TMP-MABA (1.5:1), and TMP-DNBA (0.5:1). Hygroscopicity was characterized by the dynamic vapor sorption (DVS) method. Three cocrystals significantly improved the hygroscopicity stability, and the mass change in TMP decreased from 25% to 1.64% (TMP-PABA), 0.12% (TMP-MABA), and 0.03% (TMP-DNBA) at 90% relative humidity. The melting points of the three cocrystals were all higher than TMP, among which the TMP-DNBA cocrystal had the highest melting point and showed the best stability in reducing hygroscopicity. Crystal structure analysis shows that the mesh-like structure formed by the O-H…N hydrogen bond in the TMP-DNBA cocrystal was the reason for improving the stability of TMP. Full article
(This article belongs to the Special Issue X-ray Crystallography Based Study on Molecular Structure)
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14 pages, 327 KiB  
Review
Environmental and Metabolic Risk Factors Linked to Gallbladder Dysplasia
by Andrei Bojan, Catalin Pricop, Manuela Ciocoiu, Maria Cristina Vladeanu, Iris Bararu Bojan, Oana Viola Badulescu, Minerva Codruta Badescu, Carmen Elena Plesoianu, Dan Iliescu Halitchi and Liliana Georgeta Foia
Metabolites 2024, 14(5), 273; https://doi.org/10.3390/metabo14050273 (registering DOI) - 08 May 2024
Abstract
Gallbladder disorders encompass a spectrum from congenital anomalies to inflammatory and neoplastic conditions, frequently requiring surgical intervention. Epithelial abnormalities like adenoma and metaplasia have the potential to progress to carcinoma, emphasizing the importance of histopathological assessment for early detection of malignancy. Gallbladder cancer [...] Read more.
Gallbladder disorders encompass a spectrum from congenital anomalies to inflammatory and neoplastic conditions, frequently requiring surgical intervention. Epithelial abnormalities like adenoma and metaplasia have the potential to progress to carcinoma, emphasizing the importance of histopathological assessment for early detection of malignancy. Gallbladder cancer (GBC) may be incidentally discovered during cholecystectomy for presumed benign conditions, underscoring the need for a thorough examination. However, the lack of clarity regarding the molecular mechanisms of GBC has impeded diagnostic and therapeutic advancements. Timely detection is crucial due to GBC’s aggressive nature and poor prognosis. Chronic inflammation plays a central role in carcinogenesis, causing DNA damage and oncogenic alterations due to persistent insults. Inflammatory cytokines and microRNAs are among the various mediators contributing to this process. Gallbladder calcifications, particularly stippled ones, may signal malignancy and warrant preemptive removal. Molecular pathways involving mutations in oncogenes and tumor suppressor genes drive GBC pathogenesis, with proposed sequences such as gallstone-induced inflammation leading to carcinoma formation. Understanding these mechanisms, alongside evaluating mucin characteristics and gene mutations, can deepen comprehension of GBC’s pathophysiology. This, in turn, facilitates the identification of high-risk individuals and the development of improved treatment strategies, ultimately enhancing patient outcomes. Thus, in this review, our aim has been to underscore the primary mechanisms underlying the development of gallbladder dysplasia and neoplasia. Full article
(This article belongs to the Special Issue New Biomarkers for Diagnostics in Metabolic Diseases)
13 pages, 1544 KiB  
Article
The Dominant Role of Recrystallization and Grain Growth Behaviors in the Simulated Welding Heat-Affected Zone of High-Mn Steel
by Yangwen Wang, Honghong Wang, Siyuan Peng, Bin Xia and Hai Zhu
Materials 2024, 17(10), 2218; https://doi.org/10.3390/ma17102218 (registering DOI) - 08 May 2024
Abstract
Single-pass-welding thermal cycles with different peak temperatures (Tp) were reproduced by a Gleeble 3800 to simulate the heat-affected zone (HAZ) of a Fe-24Mn-4Cr-0.4C-0.3Cu (wt.%) high manganese austenitic steel. Then, the effect of Tp on the microstructure and mechanical properties of [...] Read more.
Single-pass-welding thermal cycles with different peak temperatures (Tp) were reproduced by a Gleeble 3800 to simulate the heat-affected zone (HAZ) of a Fe-24Mn-4Cr-0.4C-0.3Cu (wt.%) high manganese austenitic steel. Then, the effect of Tp on the microstructure and mechanical properties of the HAZ were investigated. The results indicate that recrystallization and grain growth play dominant roles. Based on this, the HAZ is proposed to categorize into three zones: the recrystallization heat-affected zone (RHAZ) with a Tp of 700~900 °C, the transition heat-affected zone (THAZ) with a Tp of 900~1000 °C, and the coarse grain heat-affected zone (CGHAZ) with a Tp of 1000~1300 °C. The recrystallization fraction was 29~44% in the RHAZ, rapidly increased to 87% in the THAZ, and exceeded 95% in the CGHAZ. The average grain size was 17~19 μm in the RHAZ, slightly increased to 22 μm in the THAZ, and ultimately increased to 37 μm in the CGHAZ. The yield strength in the RHAZ and THAZ was consistent with the change in recrystallization fraction, while in the CGHAZ, it satisfied the Hall–Petch relationship with grain size. In addition, compared with the base material, the Charpy impact absorbed energy at −196 °C decreased by 22% in the RHAZ, but slightly increased in the CGHAZ. This indicates that the theory of fine grain strengthening and toughening is not entirely applicable to the HAZ of the investigated high-Mn steel. Full article
(This article belongs to the Special Issue Welding, Joining, and Additive Manufacturing of Metals and Alloys)
16 pages, 3757 KiB  
Article
Removal of Cr(VI) from Wastewater Using Acrylonitrile Grafted Cellulose Extracted from Sugarcane Bagasse
by Idrees Khan, Ashraf Ali, Alia Naz, Zenab Tariq Baig, Wisal Shah, Zia Ur Rahman, Tawaf Ali Shah, Kotb A. Attia, Arif Ahmed Mohammed and Yaser M. Hafez
Molecules 2024, 29(10), 2207; https://doi.org/10.3390/molecules29102207 (registering DOI) - 08 May 2024
Abstract
A highly efficient low-cost adsorbent was prepared using raw and chemically modified cellulose isolated from sugarcane bagasse for decontamination of Cr(VI) from wastewater. First, cellulose pulp was isolated from sugarcane bagasse by subjecting it to acid hydrolysis, alkaline hydrolysis and bleaching with sodium [...] Read more.
A highly efficient low-cost adsorbent was prepared using raw and chemically modified cellulose isolated from sugarcane bagasse for decontamination of Cr(VI) from wastewater. First, cellulose pulp was isolated from sugarcane bagasse by subjecting it to acid hydrolysis, alkaline hydrolysis and bleaching with sodium chlorate (NaClO3). Then, the bleached cellulose pulp was chemically modified with acrylonitrile monomer in the presence Fenton’s reagent (Fe+2/H2O2) to carry out grafting of acrylonitrile onto cellulose by atom transfer radical polymerization. The developed adsorbent (acrylonitrile grafted cellulose) was analyzed by X-ray diffraction analysis (XRD), scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FT-IR). Both raw cellulose and acrylonitrile grafted cellulose were used for chromium removal from wastewater. The effects of metal ion concentration, pH, adsorbent dose and time were studied, and their values were optimized. The optimum conditions for the adsorption of Cr(VI) onto raw and chemically modified cellulose were: metal ion concentration: 50 ppm, adsorbent dose: 1 g, pH: 6, and time: 60 min. The maximum efficiencies of 73% and 94% and adsorption capacities of 125.95 mg/g and 267.93 mg/g were achieved for raw and acrylonitrile grafted cellulose, respectively. High removal efficiency was achieved, owing to high surface area of 79.92 m2/g and functional active binding cites on grafted cellulose. Isotherm and kinetics studies show that the experimental data were fully fitted by the Freundlich isotherm model and pseudo first-order model. The adsorbent (acrylonitrile grafted cellulose) was regenerated using three different types of regenerating reagents and reused thirty times, and there was negligible decrease (19%) in removal efficiency after using it for 30 times. Hence, it is anticipated that acrylonitrile could be utilized as potential candidate material for commercial scale Cr(VI) removal from wastewater. Full article
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20 pages, 525 KiB  
Article
Family Caregivers’ Experiences during the COVID-19 Pandemic: Qualitative Study
by Milagros Rico-Blázquez, Raquel Sánchez-Ruano, Cristina Oter-Quintana, Elena Polentinos-Castro, Ángel Martín-García, Pedro Otones-Reyes, Damián González-Beltrán and Mercedes Martínez-Marcos
Healthcare 2024, 12(10), 970; https://doi.org/10.3390/healthcare12100970 (registering DOI) - 08 May 2024
Abstract
Background: The COVID-19 pandemic imposed lockdown measures that affected caregiving. Understanding caregivers’ context provides reveals their adaptive strategies to continue caring in this situation of uncertainty and isolation. Objective: To better understand the caregiving experiences of caregivers looking after dependent individuals living in [...] Read more.
Background: The COVID-19 pandemic imposed lockdown measures that affected caregiving. Understanding caregivers’ context provides reveals their adaptive strategies to continue caring in this situation of uncertainty and isolation. Objective: To better understand the caregiving experiences of caregivers looking after dependent individuals living in the community during the pandemic. Design: Qualitative research, phenomenological approach. Setting: Primary healthcare centers in Madrid region (Spain). Participants: 21 family caregivers. Methods: Purposive and theoretical sampling was used to recruit caregivers across nurses from primary healthcare centers. Participants were interviewed using a semi-structured interview guide to explore the caring experience. Interview transcripts were evaluated using thematic analysis. Results: The findings were categorized into two themes: “Caregivers during lockdown—providing care in a time of adversity” and “Caregiving toward normality”. The sub-themes identified were the re-structuring of before-care services and the introduction of new care approaches, managing the dependent person’s health problems, looking after oneself, and dealing with adversity. To adapt to the new normal, strategies were put in place designed to recover confidence and trust, reincorporate assistance, and reconnect with others. Conclusions: Care intensified during the pandemic. Caregivers took on the task without assistance, focusing on preventing contagion and protecting themselves to be able to continue giving care. Full article
(This article belongs to the Special Issue Patient Centred Care: Current Situation and Development)
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16 pages, 534 KiB  
Article
Color Differences of Polimerized Resin-Based Composites and Corresponding Shade Guides
by David Fernández Millán, Jose Manuel Pose Rodríguez, Gonzalo López Castro, Victor Alonso de la Peña and Mercedes Gallas Torreira
Appl. Sci. 2024, 14(10), 4002; https://doi.org/10.3390/app14104002 (registering DOI) - 08 May 2024
Abstract
Objective: The purpose of this study is to analyze and compare the colors (A2, A3 and A3.5) of polymerized resin-based composites (RBCs) with respect to the shade numbers within each product line and the VITAPAN Classical® shade guide they purported to represent. [...] Read more.
Objective: The purpose of this study is to analyze and compare the colors (A2, A3 and A3.5) of polymerized resin-based composites (RBCs) with respect to the shade numbers within each product line and the VITAPAN Classical® shade guide they purported to represent. Methods: Three A-shades (A2, A3 and A3.5) from four RBC products (Harmonize®, Empress® Direct®, Grandio® and Filtek® 500) were compared within the VITAPAN Classical® shade guide and within their own commercial shade guide. Nine disk-shaped specimens, 6 mm in diameter and 2 mm thick, were prepared for each RBC color (three of each color). The color measurements were made according to the CIE L*a*b* color scale (quantifying L*c*h*a*b* values) using a Vita Easyshade Compact IV® digital spectrophotometer. We calculated the CIEDE2000 color differences between polymerized composites and shade guides, as well as between composites. The values obtained from composites and samples of the color guides in the CIE L*a*b* space were represented by ICC3D software (Version 1.2.9) Results: The ANOVA test verified the existence of statistically significant differences between composites for the same shades (p < 0.05) except for shade A2. CIEDE2000 color differences between composites and the VITAPAN Classical® shade guide ranged from 3.5 to 13.1 depending on the composite and the shade. Conclusions: There were color differences among the polymerized resin-based composites, between these and their own shade guides/manufacturer’s commercial guides, and between the former and the corresponding samples of the VITAPAN Classical® shade guide. Clinical significance: Color selection when performing an aesthetic dental restoration is essential for the clinician and the patient to obtain an optimal result. Taking into account the color difference (∆E00) for each composite with the VITAPAN Classical® shade guide or with the manufacturers’ commercial guide allows for more precision with shade selection in aesthetic dentistry. Full article
18 pages, 1546 KiB  
Article
Flexural Performance of Reinforced Concrete Beams Strengthened with a Novel High-Strength and High-Toughness Epoxy Mortar Thin Layer
by Weizhao Li, Xuesong Huang, Xianhui Liu, Tianhao Wen, Chenggui Jing and Lingye Li
Appl. Sci. 2024, 14(10), 3999; https://doi.org/10.3390/app14103999 (registering DOI) - 08 May 2024
Abstract
The flexural performance of RC beams strengthened with a novel high-strength and high-toughness epoxy mortar thin layer was investigated through four-point flexural tests on two contrast beams and two strengthened beams. The effects of this strengthening method on the failure modes, crack distribution, [...] Read more.
The flexural performance of RC beams strengthened with a novel high-strength and high-toughness epoxy mortar thin layer was investigated through four-point flexural tests on two contrast beams and two strengthened beams. The effects of this strengthening method on the failure modes, crack distribution, load–deflection curves, and bearing capacity of the RC beams with two reinforcement ratios were studied. The experimental results revealed that the contrast beams exhibited the typical bending failure modes where the failure mode of the reinforced beam is the yielding of the tensile reinforcement of the original beam and then fracture damage of the new epoxy mortar-reinforced thin layer. No debonding phenomenon was observed between the reinforced thin layer and the original concrete, and no visible cracks appeared before the tensile failure occurred in the thin layer. The cracks in the reinforced beams developed slowly, increased in number, and decreased significantly in width and spacing. The stiffness of the strengthened beam increased significantly, while its deformation ductility coefficient noticeably decreased. Compared to the corresponding contrast beams, the cracking load for strengthened beams A1 and B1 increased by 14% and 23%, respectively; the yield load increased by 32% and 40%, respectively; and the peak load increased by 18% and 17%, respectively. Finally, a calculation method for the flexural bearing capacity of RC beams strengthened with the novel epoxy mortar thin layer based on the flat section assumption was proposed. The calculated values showed a good agreement with the experimental values (with errors at −11.73% and 4.14%, respectively), providing a valuable reference for further research and application related to this kind of reinforcement method. Full article
22 pages, 3561 KiB  
Article
A Deep Learning Approach for Accurate Path Loss Prediction in LoRaWAN Livestock Monitoring
by Mike O. Ojo, Irene Viola, Silvia Miretti, Eugenio Martignani, Stefano Giordano and Mario Baratta
Sensors 2024, 24(10), 2991; https://doi.org/10.3390/s24102991 (registering DOI) - 08 May 2024
Abstract
The agricultural sector is amidst an industrial revolution driven by the integration of sensing, communication, and artificial intelligence (AI). Within this context, the internet of things (IoT) takes center stage, particularly in facilitating remote livestock monitoring. Challenges persist, particularly in effective field communication, [...] Read more.
The agricultural sector is amidst an industrial revolution driven by the integration of sensing, communication, and artificial intelligence (AI). Within this context, the internet of things (IoT) takes center stage, particularly in facilitating remote livestock monitoring. Challenges persist, particularly in effective field communication, adequate coverage, and long-range data transmission. This study focuses on employing LoRa communication for livestock monitoring in mountainous pastures in the north-western Alps in Italy. The empirical assessment tackles the complexity of predicting LoRa path loss attributed to diverse land-cover types, highlighting the subtle difficulty of gateway deployment to ensure reliable coverage in real-world scenarios. Moreover, the high expense of densely deploying end devices makes it difficult to fully analyze LoRa link behavior, hindering a complete understanding of networking coverage in mountainous environments. This study aims to elucidate the stability of LoRa link performance in spatial dimensions and ascertain the extent of reliable communication coverage achievable by gateways in mountainous environments. Additionally, an innovative deep learning approach was proposed to accurately estimate path loss across challenging terrains. Remote sensing contributes to land-cover recognition, while Bidirectional Long Short-Term Memory (Bi-LSTM) enhances the path loss model’s precision. Through rigorous implementation and comprehensive evaluation using collected experimental data, this deep learning approach significantly curtails estimation errors, outperforming established models. Our results demonstrate that our prediction model outperforms established models with a reduction in estimation error to less than 5 dB, marking a 2X improvement over state-of-the-art models. Overall, this study signifies a substantial advancement in IoT-driven livestock monitoring, presenting robust communication and precise path loss prediction in rugged landscapes. Full article
(This article belongs to the Section Smart Agriculture)
20 pages, 2601 KiB  
Article
Reducing Artisanal Fishery Impact on Marine Community: New Data from Comparison of Innovative and Traditional Gear
by Manfredi Madia, Massimiliano Bottaro, Tiziana Cillari, Andrea Li Vorsi, Luca Castriota, Maria Rita Amico, Sergio Bizzarri, Teresa Maggio, Manuela Falautano, Michele Gristina, Ilaria Di Lauro, Floriana Trova, Patrizia Perzia, Roberto D’Ambra, Enrico Casola and Mauro Sinopoli
Fishes 2024, 9(5), 171; https://doi.org/10.3390/fishes9050171 (registering DOI) - 08 May 2024
Abstract
Fishery resources overexploitation, together with bycatch and discards, have an impact on marine ecosystems. The adoption of technologically innovative gears is a possible solution to reduce the discard and to enhance the sustainability of fishery, mainly in artisanal fisheries that represent about 80% [...] Read more.
Fishery resources overexploitation, together with bycatch and discards, have an impact on marine ecosystems. The adoption of technologically innovative gears is a possible solution to reduce the discard and to enhance the sustainability of fishery, mainly in artisanal fisheries that represent about 80% of the EU Mediterranean fleet. In the perspective of fishery sustainability, it is necessary to study and test alternative gears to the traditional ones, also with collaboration of fishers. In the present study, results of experimental fishing activities carried out in two Mediterranean areas with traditional and innovative gears of small-scale fishing are reported. Thirty-four hauls were carried out to compare the catch of two types of trammel nets: a traditional one and experimental guarding net. Additionally, 12 hauls were carried out to compare collapsible pots and traditional pots. No significant differences were recorded between trammel nets in terms of commercial catch and discard. However, interesting differences in discard composition were recorded, with higher Elasmobranchs presence in trammel nets, including species assessed as critically endangered and vulnerable. The use of trapula pots in place of traditional ones showed a lower discard of specific resources and an advantage for fishers in terms of space occupied on board. Full article
(This article belongs to the Section Fishery Facilities, Equipment, and Information Technology)
15 pages, 972 KiB  
Review
Advancing Smart Lithium-Ion Batteries: A Review on Multi-Physical Sensing Technologies for Lithium-Ion Batteries
by Wenwei Wang, Shuaibang Liu, Xiao-Ying Ma, Jiuchun Jiang and Xiao-Guang Yang
Energies 2024, 17(10), 2273; https://doi.org/10.3390/en17102273 (registering DOI) - 08 May 2024
Abstract
Traditional battery management systems (BMS) encounter significant challenges, including low precision in predicting battery states and complexities in managing batteries, primarily due to the scarcity of collected signals. The advancement towards a “smart battery”, equipped with diverse sensor types, promises to mitigate these [...] Read more.
Traditional battery management systems (BMS) encounter significant challenges, including low precision in predicting battery states and complexities in managing batteries, primarily due to the scarcity of collected signals. The advancement towards a “smart battery”, equipped with diverse sensor types, promises to mitigate these issues. This review highlights the latest developments in smart sensing technologies for batteries, encompassing electrical, thermal, mechanical, acoustic, and gas sensors. Specifically, we address how these different signals are perceived and how these varied signals could enhance our comprehension of battery aging, failure, and thermal runaway mechanisms, contributing to the creation of BMS that are safer and more reliable. Moreover, we analyze the limitations and challenges faced by different sensor applications and discuss the advantages and disadvantages of each sensing technology. Conclusively, we present a perspective on overcoming future hurdles in smart battery development, focusing on appropriate sensor design, optimized integration processes, efficient signal transmission, and advanced management systems. Full article
20 pages, 6798 KiB  
Article
A Calculation and Optimization Method for the Theoretical Reclamation Timing of Cropland
by Hejian Yin, Guangli Guo, Huaizhan Li and Tiening Wang
Land 2024, 13(5), 638; https://doi.org/10.3390/land13050638 (registering DOI) - 08 May 2024
Abstract
In mining areas with high groundwater tables, mining subsidence can lead to the inundation of cropland by water, causing damage to cropland and posing a threat to national food security. The implementation of concurrent mining and reclamation techniques can effectively enhance the reclamation [...] Read more.
In mining areas with high groundwater tables, mining subsidence can lead to the inundation of cropland by water, causing damage to cropland and posing a threat to national food security. The implementation of concurrent mining and reclamation techniques can effectively enhance the reclamation rate of cropland. This technique requires engineers to initiate reclamation measures before cropland waterlogging occurs. Therefore, when mining a panel underground, an accurate calculation of the time when cropland becomes waterlogged, known as the theoretical reclamation timing, is crucial. To address this issue, this study proposes a computational method for the theoretical reclamation timing of cropland under the conditions of single-panel mining based on intelligent optimization algorithms. In addition, this paper also proposes an optimization method for the theoretical reclamation timing of cropland within a district based on an intelligent optimization algorithm. Utilizing this method makes optimizing the layout of multiple panels possible, thereby delaying the theoretical reclamation timing for cropland within a district. This approach aims to shorten the duration of reclamation projects and minimize their interference with agricultural activities. Through experimental validation, this paper demonstrates the reliability of these two methods. This study is beneficial for the rational planning of reclamation projects. Full article

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