The 2023 MDPI Annual Report has
been released!
 
5 pages, 242 KiB  
Editorial
Is Online Technology the Hope in Uncertain Times for Higher Education?
by Anthony G. Picciano
Educ. Sci. 2024, 14(5), 499; https://doi.org/10.3390/educsci14050499 (registering DOI) - 07 May 2024
Abstract
Significant technological challenges are affecting societies across the world and online technology continues to assume a pivotal place in all organizations: commercial and non-commercial, governmental and non-governmental, and all forms of education [...] Full article
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16 pages, 4115 KiB  
Article
A Machine Learning-Based Tropospheric Prediction Approach for High-Precision Real-Time GNSS Positioning
by Jianping Chen and Yang Gao
Sensors 2024, 24(10), 2957; https://doi.org/10.3390/s24102957 (registering DOI) - 07 May 2024
Abstract
For high-precision positioning applications, various GNSS errors need to be mitigated, including the tropospheric error, which remains a significant error source as it can reach up to a few meters. Although some commercial GNSS correction data providers, such as the Quasi-Zenith Satellite System [...] Read more.
For high-precision positioning applications, various GNSS errors need to be mitigated, including the tropospheric error, which remains a significant error source as it can reach up to a few meters. Although some commercial GNSS correction data providers, such as the Quasi-Zenith Satellite System (QZSS) Centimeter Level Augmentation Service (CLAS), have developed real-time precise regional troposphere products, the service is available only in limited regional areas. The International GNSS Service (IGS) has provided precise troposphere correction data in TRO format post-mission, but its long latency of 1 to 2 weeks makes it unable to support real-time applications. In this work, a real-time troposphere prediction method based on the IGS post-processing products was developed using machine learning techniques to eliminate the long latency problem. The test results from tropospheric predictions over a year using the proposed method indicate that the new method can achieve a prediction accuracy (RMSE) of 2 cm, making it suitable for real-time applications. Full article
(This article belongs to the Special Issue GNSS Signals and Precise Point Positioning)
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16 pages, 18430 KiB  
Article
Microwave-Solvothermal Synthesis of Mesoporous CeO2/CNCs Nanocomposite for Enhanced Room Temperature NO2 Detection
by Yanming Sun, Xiaoying Lu, Yanchen Huang and Guoping Wang
Nanomaterials 2024, 14(10), 812; https://doi.org/10.3390/nano14100812 (registering DOI) - 07 May 2024
Abstract
Nitrogen dioxide (NO2) gas sensors are pivotal in upholding environmental integrity and human health, necessitating heightened sensitivity and exceptional selectivity. Despite the prevalent use of metal oxide semiconductors (MOSs) for NO2 detection, extant solutions exhibit shortcomings in meeting practical application [...] Read more.
Nitrogen dioxide (NO2) gas sensors are pivotal in upholding environmental integrity and human health, necessitating heightened sensitivity and exceptional selectivity. Despite the prevalent use of metal oxide semiconductors (MOSs) for NO2 detection, extant solutions exhibit shortcomings in meeting practical application criteria, specifically in response, selectivity, and operational temperatures. Here, we successfully employed a facile microwave-solvothermal method to synthesize a mesoporous CeO2/CNCs nanocomposite. This methodology entails the rapid and comprehensive dispersion of CeO2 nanoparticles onto helical carbon nanocoils (CNCs), resulting in augmented electronic conductivity and an abundance of active sites within the composite. Consequently, the gas-sensing sensitivity of the nanocomposite at room temperature experienced a notable enhancement. Moreover, the presence of cerium oxide and the conversion of Ce3+ and Ce4+ ions facilitated the generation of oxygen vacancies in the composites, thereby further amplifying the sensing performance. Experimental outcomes demonstrate that the nanocomposite exhibited an approximate 9-fold increase in response to 50 ppm NO2 in comparison to pure CNCs at room temperature. Additionally, the CeO2/CNCs sensor displayed remarkable selectivity towards NO2 when exposed to gases such as NH3, CO, SO2, CO2, and C2H5OH. This straightforward microwave-solvothermal method presents an appealing strategy for the research and development of intelligent sensors based on CNCs nanomaterials. Full article
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19 pages, 872 KiB  
Article
Allegorical Vision: The Promotion of the Senses and the Vision of the Entendimiento in Calderón’s El cubo de la Almudena
by Katerina J. Levinson
Humanities 2024, 13(3), 72; https://doi.org/10.3390/h13030072 (registering DOI) - 07 May 2024
Abstract
The following article examines the role of the sentidos and the entendimiento in Pedro Calderón de la Barca’s auto sacramental, El cubo de la Almudena. While scholarship recognises the pervasiveness of the play on the senses in early modern Spain, scholars [...] Read more.
The following article examines the role of the sentidos and the entendimiento in Pedro Calderón de la Barca’s auto sacramental, El cubo de la Almudena. While scholarship recognises the pervasiveness of the play on the senses in early modern Spain, scholars often either deny or overemphasise the reliability of the senses as a means of truth acquisition. Moreover, scholarship often attaches too much weight to hearing, thus neglecting the role of the eyes of the entendimiento. Based on a Thomistic framework, Calderón demonstrates that the literal element of allegory relies on the active vehicle of the senses to serve as guides for the entendimiento and an entrance into devotion. Although hearing plays a central role in the play, it serves as a herald for sight, by which the devotee exercises faith. Moreover, where the sentidos prove limited, the entendimiento is an auxiliary support that makes up for their lack, seeing beyond sensual perception through faith. In this way, the medium of the auto sacramental and the theology of the Eucharist train the audience to use the vision of faith through both the senses and the entendimiento to see the allegorical meaning of the play, the divine nature of the Eucharist provided by Mary. Full article
(This article belongs to the Special Issue The Eye in Spanish Golden Age Medicine, Anatomy, and Literature)
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21 pages, 7175 KiB  
Article
A Hybrid Approach Combining Shape-Based and Docking Methods to Identify Novel Potential P2X7 Antagonists from Natural Product Databases
by Natiele Carla da Silva Ferreira, Lucas Gasparello Viviani, Lauro Miranda Lima, Antonia Tavares do Amaral, João Victor Paiva Romano, Anderson Lage Fortunato, Rafael Ferreira Soares, Anael Viana Pinto Alberto, Jose Aguiar Coelho Neto and Luiz Anastacio Alves
Pharmaceuticals 2024, 17(5), 592; https://doi.org/10.3390/ph17050592 (registering DOI) - 07 May 2024
Abstract
P2X7 is an ATP-activated purinergic receptor implicated in pro-inflammatory responses. It is associated with the development of several diseases, including inflammatory and neurodegenerative conditions. Although several P2X7 receptor antagonists have recently been reported in the literature, none of them is approved for clinical [...] Read more.
P2X7 is an ATP-activated purinergic receptor implicated in pro-inflammatory responses. It is associated with the development of several diseases, including inflammatory and neurodegenerative conditions. Although several P2X7 receptor antagonists have recently been reported in the literature, none of them is approved for clinical use. However, the structure of the known antagonists can serve as a scaffold for discovering effective compounds in clinical therapy. This study aimed to propose an improved virtual screening methodology for the identification of novel potential P2X7 receptor antagonists from natural products through the combination of shape-based and docking approaches. First, a shape-based screening was performed based on the structure of JNJ-47965567, a P2X7 antagonist, using two natural product compound databases, MEGx (~5.8 × 103 compounds) and NATx (~32 × 103 compounds). Then, the compounds selected by the proposed shape-based model, with Shape–Tanimoto score values ranging between 0.624 and 0.799, were filtered for drug-like properties. Finally, the compounds that met the drug-like filter criteria were docked into the P2X7 allosteric binding site, using the docking programs GOLD and DockThor. The docking poses with the best score values were submitted to careful visual inspection of the P2X7 allosteric binding site. Based on our established visual inspection criteria, four compounds from the MEGx database and four from the NATx database were finally selected as potential P2X7 receptor antagonists. The selected compounds are structurally different from known P2X7 antagonists, have drug-like properties, and are predicted to interact with key P2X7 allosteric binding pocket residues, including F88, F92, F95, F103, M105, F108, Y295, Y298, and I310. Therefore, the combination of shape-based screening and docking approaches proposed in our study has proven useful in selecting potential novel P2X7 antagonist candidates from natural-product-derived compounds databases. This approach could also be useful for selecting potential inhibitors/antagonists of other receptors and/or biological targets. Full article
(This article belongs to the Special Issue Structure and Ligand Based Drug Design)
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24 pages, 3470 KiB  
Article
Improving the Efficiency and Environmental Friendliness of Urban Stormwater Management by Enhancing the Water Filtration Model in Rain Gardens
by Maryna Kravchenko, Yuliia Trach, Roman Trach, Tetiana Tkachenko and Viktor Mileikovskyi
Water 2024, 16(10), 1316; https://doi.org/10.3390/w16101316 (registering DOI) - 07 May 2024
Abstract
Rain gardens are used to solve urban problems related to the negative impact of stormwater. (1) Scientific contributions from different countries provide general guidelines for the design and operation of rain gardens in different geographical areas. Given the small spatial scale of rain [...] Read more.
Rain gardens are used to solve urban problems related to the negative impact of stormwater. (1) Scientific contributions from different countries provide general guidelines for the design and operation of rain gardens in different geographical areas. Given the small spatial scale of rain gardens, the use of existing infiltration models often leads to design errors. (2) The purpose of this paper is to develop a hydrological model by introducing a system of equations that extends the ability to calculate the rate, flow rate and time of saturation of layers with moisture and rainwater leakage from the rain garden system. (3) The results obtained allow us to describe the dynamic processes of passage and saturation of layers of the rain garden at a certain point in time, which extends the ability to calculate the flow rate. It was established that the smaller the area of the rain garden compared to the area of the catchment basin, the faster it reaches its full saturation. Increasing the thickness of the rain garden layers allows for an increase in the efficiency of water retention at a lower value of the area ratio. (4) The practical significance of the results obtained is especially important for the correct description of hydrodynamics in the system and determining the optimal conditions for the effective functioning and management of the rain garden structure for any climatic region. Full article
(This article belongs to the Special Issue Stormwater Management in Sponge Cities)
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28 pages, 8281 KiB  
Article
Development of an Integrated Urban Flood Model and Its Application in a Concave-Down Overpass Area
by Yuna Yan, Han Zhang, Na Zhang and Chuhan Feng
Remote Sens. 2024, 16(10), 1650; https://doi.org/10.3390/rs16101650 (registering DOI) - 07 May 2024
Abstract
Urban floods caused by extreme rainstorm events have increased in recent decades, particularly in concave-down bridge zones. To simulate urban flooding processes accurately, an integrated urban flood model (IUFM) was constructed by coupling a distributed urban surface runoff model based on the cellular [...] Read more.
Urban floods caused by extreme rainstorm events have increased in recent decades, particularly in concave-down bridge zones. To simulate urban flooding processes accurately, an integrated urban flood model (IUFM) was constructed by coupling a distributed urban surface runoff model based on the cellular automata framework (CA-DUSRM), a widely used pipe convergence module in the storm water management model (SWMM), with an inundation module that describes the overflow expansion process associated with terrain and land-cover. The IUFM was used in a case study of the Anhua Bridge (a typical concave-down overpass) study area in Beijing, China. The spatial-temporal variations in flood depth modeled by the IUFM were verified to be reliable by comparison with actual measurements and other simulations. The validated IUFM was used to obtain temporal variations in flood range, depth, and volume under four rainstorm scenarios (return periods of 3-year, 10-year, 50-year, and 100-year). The results showed that the surface runoff process, overflow from drainage networks, and overflow expansion process could affect the flooding status by changing the composition and spatial configuration of pervious or impervious patches, drainage capacity, and underlying surface characteristics (such as terrain and land-cover). Overall, although the simulation results from the IUFM contain uncertainties from the model structures and inputs, the IUFM is an effective tool that can provide accurate and timely information to prevent and control urban flood disasters and provide decision-making support for long-term storm water management and sponge city construction. Full article
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25 pages, 3074 KiB  
Article
Optimal Planning of PV Sources and D-STATCOM Devices with Network Reconfiguration Employing Modified Ant Lion Optimizer
by Sujatha B. C., Usha A. and Geetha R. S.
Energies 2024, 17(10), 2238; https://doi.org/10.3390/en17102238 (registering DOI) - 07 May 2024
Abstract
This research emphasizes a meta-heuristic modified ant lion optimizer (MALO) optimization approach for the simultaneous utilization of DSTATCOM devices and distributed photovoltaic (PV) sources with network reconfiguration in a radial power distribution scheme. In a radial power distribution network with network reconfiguration, the [...] Read more.
This research emphasizes a meta-heuristic modified ant lion optimizer (MALO) optimization approach for the simultaneous utilization of DSTATCOM devices and distributed photovoltaic (PV) sources with network reconfiguration in a radial power distribution scheme. In a radial power distribution network with network reconfiguration, the majority of the research is based on constant power model analysis. However, it is noticed that load models have a substantial impact on the distributed PV sources and the DSTATCOM device’s optimal size and position. The effect of the constant power (CP) and polynomial (ZIP) with load growth load models for the simultaneous insertion of distributed PV sources and DSTATCOM devices with network reconfiguration is examined in this research work for power system planning. The penetration levels of distributed PV sources considered for the investigation are 25%, 50%, 75%, and 100%. The principal objective of this research is to reduce network total power losses, enhance the voltage magnitude profile at all buses, and reduce the overall operating cost while adhering to equality and inequality constraints. The proposed algorithm is verified on 118-node test systems. The investigation is carried out for planning network upgrading to a high-voltage distribution system (HVDS) on 317 nodes in the rural Bangalore Electricity Supply Company Limited (BESCOM) radial distribution scheme. The simulated results obtained with this method are validated with the BAT algorithm and techniques available in the literature. It is observed that in the IEEE 118-bus system, via the simultaneous placement and sizing of PV sources considering a 25% penetration level and DSTATCOM devices during network reconfiguration, the total power loss reduction is 41.47% and 42.98% for the constant power model and ZIP with the load growth model. For the 317-bus system, the total power loss reduction observed for 11 kV is 49.77% and 59.34% for the constant power model and ZIP model with load growth. Similarly, for the 22 kV system, the power loss reduction observed is 51.69% and 55.75% for the constant power model and ZIP with the load growth model. Full article
(This article belongs to the Section F2: Distributed Energy System)
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19 pages, 326 KiB  
Article
How Managerial Practices Impact Perceived Organizational Effectiveness: A Study of Corporate Foundations
by Theresa Gehringer
Adm. Sci. 2024, 14(5), 96; https://doi.org/10.3390/admsci14050096 (registering DOI) - 07 May 2024
Abstract
The organizational effectiveness of nonprofit organizations (NPOs) has received considerable attention from the scientific research community and society. Nonprofit scholars call for more empirical research that tests existing theories and develops multidimensional frameworks at the organizational level, with a focus on actual management [...] Read more.
The organizational effectiveness of nonprofit organizations (NPOs) has received considerable attention from the scientific research community and society. Nonprofit scholars call for more empirical research that tests existing theories and develops multidimensional frameworks at the organizational level, with a focus on actual management practices. Previous studies have suggested that a broad set of management practices at the program and organizational levels have positive implications for the perceived effectiveness of NPOs. This study evaluates and refines a conceptual model of the antecedents of organizational effectiveness and validates its applicability in the context of charitable foundations established by corporations. Based on survey data from their executive leaders, this study’s empirical findings suggest that perceived organizational effectiveness is less affected by a broad set of management practices and is driven by a few selected best practices that focus on specific stakeholder groups (i.e., experts). Moreover, the results show that certain organizational characteristics, such as organizational experience, can strengthen the perceived effectiveness of charitable foundations. Overall, the results of this study may help nonprofit executive leaders to better understand that a careful selection and implementation of specific practices might be more beneficial for an organization’s effectiveness than an extensive list of practices. Moreover, this study contributes on a broader theoretical level to the study of multidimensional frameworks as a suitable measure for identifying key antecedents of leader-perceived organizational effectiveness across different types of NPOs. Full article
(This article belongs to the Section Strategic Management)
6 pages, 557 KiB  
Communication
Incidence of Ophthalmological Complications in NF-1 Patients Treated with MEK Inhibitors
by Lena Hummel, May Ameri, Shaikha Alqahtani, Zsila Sadighi and Nagham Al-Zubidi
Curr. Oncol. 2024, 31(5), 2644-2649; https://doi.org/10.3390/curroncol31050199 (registering DOI) - 07 May 2024
Abstract
MEK inhibitors (MEKi) represent innovative and promising treatments for managing manifestations of neurofibromatosis type 1 (NF1). To mitigate potential ophthalmic side effects, such as MEKi-associated retinopathy (MEKAR), patients undergoing MEKi therapy routinely receive ophthalmology evaluations. Our study aims to assess the necessity of [...] Read more.
MEK inhibitors (MEKi) represent innovative and promising treatments for managing manifestations of neurofibromatosis type 1 (NF1). To mitigate potential ophthalmic side effects, such as MEKi-associated retinopathy (MEKAR), patients undergoing MEKi therapy routinely receive ophthalmology evaluations. Our study aims to assess the necessity of this regular screening within a predominantly pediatric NF1 population by examining the occurrence of ocular adverse events (OAE). A retrospective study evaluated 45 NF1 patients receiving MEKi. Inclusion criteria included baseline and follow-up examinations following the initiation of MEKi therapy. At each assessment, a comprehensive eye evaluation was performed, comprising a dilated fundus examination, ocular coherence tomography of the macula and nerve fiber layer, and Humphrey visual field testing. Twenty-six patients, with an average age of 13 years (range 2–23 years) and an average follow-up duration of 413 days were included in the analysis. Three different MEKi were used: selumetinib (77%), trametinib (23%), and mirdametinib (4%). None of the patients experienced retinopathy at any point during the study. Some patients had pre-existing optic neuropathies (27%), but no instances of nerve changes occurred after commencing MEKi therapy. Four patients (15%) exhibited symptoms of dry eye, all of which were effectively managed with topical lubrication. Full article
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30 pages, 600 KiB  
Article
Denominal -ed Adjectives and Their Adjectival Status in English Morphology
by Takashi Ishida
Languages 2024, 9(5), 169; https://doi.org/10.3390/languages9050169 (registering DOI) - 07 May 2024
Abstract
In the study of English denominal adjectives, scholarly attention has predominantly centred on those with Latinate suffixes (e.g., -al, -ary, and -ic/-ical), which are well-known as relational adjectives (RAdjs) and are extensively scrutinised in the [...] Read more.
In the study of English denominal adjectives, scholarly attention has predominantly centred on those with Latinate suffixes (e.g., -al, -ary, and -ic/-ical), which are well-known as relational adjectives (RAdjs) and are extensively scrutinised in the existing literature. Conversely, those with English native suffixes (e.g., -en, -ern, -y, and -ed) have not undergone thorough examination to date. In the present study, I delve specifically into denominal adjectives with the suffix -ed (-ed Adjs), such as bearded, long-tailed, and shirt-sleeved. I present a novel basic picture of these adjectives, setting forth the following two central propositions: (i) -ed Adjs are a type of RAdj and (ii) undergo conversion to qualitative adjectives (QAdjs) (e.g., bearded man vs. bearded rock) akin to the better-known Latinate RAdjs (e.g., grammatical error vs. grammatical sentence). The analysis is conducted by examining suffixal etymology (i.e., Latinate or Germanic), suffixal properties (i.e., all-purpose or dedicated), and the driving factor for QAdj-forming conversion (i.e., the modal attribute true). These propositions and analyses collectively enrich our comprehensive understanding of the semantic and morphosyntactic properties of -ed Adjs within the realm of English morphology. Full article
(This article belongs to the Special Issue Word-Formation Processes in English)
23 pages, 2607 KiB  
Article
Implementing Additive Manufacturing in Orthopedic Shoe Supply Chains—Cost and Lead Time Comparison
by Victor Verboeket, Harold Krikke and Mika Salmi
Logistics 2024, 8(2), 49; https://doi.org/10.3390/logistics8020049 (registering DOI) - 07 May 2024
Abstract
Background: Additive manufacturing (AM) for patient-specific medical care products offers great opportunities. However, evidence about the supply chain (SC) performance impact based on empirical data is limited. Methods: In this case study, we gathered real-life data about a traditional manufacturing orthopedic [...] Read more.
Background: Additive manufacturing (AM) for patient-specific medical care products offers great opportunities. However, evidence about the supply chain (SC) performance impact based on empirical data is limited. Methods: In this case study, we gathered real-life data about a traditional manufacturing orthopedic shoe SC and developed future scenarios in which AM is introduced at various points and with different degrees of penetration in the SC. Results: Presently, AM can only replace traditional manufacturing of tools and shoe components at a higher total cost. However, with maturing technology, the complete AM production of orthopedic shoes is expected to become feasible. Theoretically, that could disrupt existing SCs, eliminating 70% of the SC steps, improving SC lead time by 90%, and altering SC relations. However, certain thresholds currently prevent disruption. Specifically, the AM of complete orthopedic shoes has to become possible, manufacturing prices have to drop, and traditional craftsmanship has to be integrated into the digital product design. Conclusions: A framework for transition pathways, including directions for future research, is formed. Findings provide valuable insights for scholars and decision makers in the patient-specific products industry, health insurance providers, and healthcare policy makers to be better prepared by adjusting SC designs, relationships, and remuneration programs while AM technology develops towards maturity. Full article
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20 pages, 13915 KiB  
Article
Canine Visceral Leishmaniasis: A Histological and Immunohistochemical Study of Fibropoiesis in Chronic Interstitial Pneumonitis
by Frederico C. Gonçalves, Ramon de Alencar Pereira, Adriano Francisco Alves, Aldair Pinto Woyames Junio, Ricardo T. Fujiwara, David M. Mosser, Helida Monteiro Andrade, Geovanni D. Cassali, Enio Ferreira and Wagner Luiz Tafuri
Microorganisms 2024, 12(5), 941; https://doi.org/10.3390/microorganisms12050941 (registering DOI) - 07 May 2024
Abstract
We studied some fibrotic aspects of chronic interstitial pneumonitis in the lungs of dogs infected with Leishmania infantum. The lungs of eleven naturally infected dogs, twelve experimentally infected with two distinct strains of L. infantum (BH401 and BH46), and six uninfected (controls) [...] Read more.
We studied some fibrotic aspects of chronic interstitial pneumonitis in the lungs of dogs infected with Leishmania infantum. The lungs of eleven naturally infected dogs, twelve experimentally infected with two distinct strains of L. infantum (BH401 and BH46), and six uninfected (controls) dogs, were analyzed by histological, parasitological, and immunohistochemical studies. Conventional histology (HE), collagen deposition (Gomori’s silver staining for reticulin collagen fibers), and immunohistochemistry for myofibroblast characterization were carried out based on the cellular expression of alpha-smooth muscle actin, vimentin, cytokeratin, E-cadherin, snail antigen homologue 1 (SNAI1) (Snail), and the cytokine expression of transforming growth factor-beta (TGF-β). Parasitological screening was carried out using conventional polymerase chain reaction (PCR) and the immunohistochemical reaction of streptavidin–peroxidase for visualizing Leishmania amastigotes. Dogs naturally infected with L. infantum and experimentally infected with L. infantum BH401 strains showed intense interstitial pneumonitis characterized by thickening of the alveolar septa as a consequence of an intense diffuse and focal (plaques) chronic exudate of mononuclear cells associated with fibrogenesis. The expression of alpha-actin, vimentin, and TGF-β was higher in the lung interstitium of all infected dogs than in the other two groups (BH46 strain and controls). Moreover, in both the naturally and experimentally infected dog (BH401 strain) groups, the expression of Snail was moderate to intense in contrast to the other groups. Based on these immunohistochemical results, we concluded that mesenchymal cells are active in promoting changes in the extracellular matrix in the lungs of dogs naturally and experimentally infected with L. infantum, but it depends on the virulence of the parasite. Full article
(This article belongs to the Special Issue New Advancements in the Field of Leishmaniasis)
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26 pages, 6315 KiB  
Article
Scalable Compositional Digital Twin-Based Monitoring System for Production Management: Design and Development in an Experimental Open-Pit Mine
by Nabil El Bazi, Oussama Laayati, Nouhaila Darkaoui, Adila El Maghraoui, Nasr Guennouni, Ahmed Chebak and Mustapha Mabrouki
Designs 2024, 8(3), 40; https://doi.org/10.3390/designs8030040 (registering DOI) - 07 May 2024
Abstract
While digital twins (DTs) have recently gained prominence as a viable option for creating reliable asset representations, many existing frameworks and architectures in the literature involve the integration of different technologies and paradigms, including the Internet of Things (IoTs), data modeling, and machine [...] Read more.
While digital twins (DTs) have recently gained prominence as a viable option for creating reliable asset representations, many existing frameworks and architectures in the literature involve the integration of different technologies and paradigms, including the Internet of Things (IoTs), data modeling, and machine learning (ML). This complexity requires the orchestration of these different technologies, often resulting in subsystems and composition frameworks that are difficult to seamlessly align. In this paper, we present a scalable compositional framework designed for the development of a DT-based production management system (PMS) with advanced production monitoring capabilities. The conducted approach used to design the compositional framework utilizes the Factory Design and Improvement (FDI) methodology. Furthermore, the validation of our proposed framework is illustrated through a case study conducted in a phosphate screening station within the context of the mining industry. Full article
(This article belongs to the Special Issue Mixture of Human and Machine Intelligence in Digital Manufacturing)
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28 pages, 6607 KiB  
Article
The InnoRec Process: A Comparative Study of Three Mainstream Routes for Spent Lithium-Ions Battery Recycling Based on the Same Feedstock
by Hao Qiu, Daniel Goldmann, Christin Stallmeister, Bernd Friedrich, Maximilian Tobaben, Arno Kwade, Christoph Peschel, Martin Winter, Sascha Nowak, Tony Lyon and Urs A. Peuker
Sustainability 2024, 16(9), 3876; https://doi.org/10.3390/su16093876 - 06 May 2024
Abstract
Among the technologies used for spent lithium-ion battery recycling, the common approaches include mechanical treatment, pyrometallurgical processing and hydrometallurgical processing. These technologies do not stand alone in a complete recycling process but are combined. The constant changes in battery materials and battery design [...] Read more.
Among the technologies used for spent lithium-ion battery recycling, the common approaches include mechanical treatment, pyrometallurgical processing and hydrometallurgical processing. These technologies do not stand alone in a complete recycling process but are combined. The constant changes in battery materials and battery design make it a challenge for the existing recycling processes, and the need to design efficient and robust recycling processes for current and future battery materials has become a critical issue today. Therefore, this paper simplifies the current treatment technologies into three recycling routes, namely, the hot pyrometallurgical route, warm mechanical route and cold mechanical route. By using the same feedstock, the three routes are compared based on the recovery rate of the six elements (Al, Cu, C, Li, Co and Ni). The three different recycling routes represent specific application scenarios, each with their own advantages and disadvantages. In the hot pyrometallurgical route, the recovery of Co is over 98%, and the recovery of Ni is over 99%. In the warm mechanical route, the recovery of Li can reach 63%, and the recovery of graphite is 75%. In the cold mechanical route, the recovery of Cu can reach 75%, and the recovery of Al is 87%. As the chemical compositions of battery materials and various doping elements continue to change today, these three recycling routes could be combined in some way to improve the overall recycling efficiency of batteries. Full article
(This article belongs to the Special Issue Development and Optimization of Sustainable Metal Recovery Processes)
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12 pages, 1431 KiB  
Article
Trends in Shoulder Arthroplasty in Germany: A 10-Year Epidemiological Analysis of Patients with Primary Osteoarthritis of the Shoulder
by Felix Frederik Hochberger, Philipp Herrmann, Maximilian Rudert, Kilian List and Ioannis Stratos
Healthcare 2024, 12(9), 949; https://doi.org/10.3390/healthcare12090949 - 06 May 2024
Abstract
Shoulder arthroplasty has significantly gained popularity in orthopedic surgery, driven by progress in prosthesis design and surgical techniques. This study explored the epidemiology of shoulder arthroplasty, analyzing healthcare data from 2012 to 2022 for primary osteoarthritis of the shoulder. The data included patient [...] Read more.
Shoulder arthroplasty has significantly gained popularity in orthopedic surgery, driven by progress in prosthesis design and surgical techniques. This study explored the epidemiology of shoulder arthroplasty, analyzing healthcare data from 2012 to 2022 for primary osteoarthritis of the shoulder. The data included patient demographics and types of surgical procedures. Data analysis indicates a higher utilization rate of reverse total shoulder arthroplasty (RTSA; n = 41,251) over total- (TSA; n = 18,679) and hemiarthroplasty (HSA; n = 12,827) for primary shoulder osteoarthritis. Overall, a significant increase in RTSA procedures from n = 2237 (2012) to n = 5415 (2022) was observed, representing more than a two-fold increase of 121.1%. The relative proportion of RTSA among all types of shoulder arthroplasty increased from 39% (2012) to 68.6% (2022), while HSA decreased and TSA essentially remained constant. Age analysis identified the following peaks: RTSA, 77 ± 7 y; HSA, 68 ± 12 y; and TSA, 67 ± 10 y. Among the over 60s, significantly more women were treated with any type of prosthesis, whereas in young patients (45 to 59 y), more men received HSA or TSA. Our study confirms that RTSA has become the preferred choice for elderly patients in Germany, reflecting the prevailing preference despite varying patient ages and conditions, with a noted difference in sex in treatment prevalence. Full article
(This article belongs to the Special Issue Health Service Interventions in Musculoskeletal Disorders)
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18 pages, 2158 KiB  
Article
How Credible Is the 25-Year Photovoltaic (PV) Performance Warranty?—A Techno-Financial Evaluation and Implications for the Sustainable Development of the PV Industry
by Pao-Hsiang Hsi and Joseph C. P. Shieh
Sustainability 2024, 16(9), 3880; https://doi.org/10.3390/su16093880 (registering DOI) - 06 May 2024
Abstract
To support the bankability of PV projects, PV manufacturers have been offering some of the longest warranties in the world, typically in the range of 25–30 years. During the warranty period, PV manufacturers guarantee that the degradation of PV modules will not exceed [...] Read more.
To support the bankability of PV projects, PV manufacturers have been offering some of the longest warranties in the world, typically in the range of 25–30 years. During the warranty period, PV manufacturers guarantee that the degradation of PV modules will not exceed 0.4–0.6% each year, or the buyer can at any time make a claim to the manufacturer for replacement or compensation for the shortfall. Due to PV popularity, the performance warranty terms have become more and more competitive each year. However, long-term PV operating data are very limited, and the bankruptcy of PV manufacturers has been quite common. Without a proper methodology to assess the adequacy of the warranty fund (WF) reserves of PV manufacturers, the 25-year performance warranty can reflect an empty promise. To ensure sustainable development of the PV industry, this study develops a probability-weighted expected value method to determine the necessary WF reserve based on benchmark field degradation data and a prevailing degradation cap of 0.55% per year. The simulation results show that, unless the manufacturer’s degradation pattern is significantly better than the benchmark degradation profile, 1.302% of the sales value is required for the WF reserve. To the best of our knowledge, this is the first study that provides WF reserve requirement estimation for 25-year PV performance warranties. The results will provide transparency for PV investors and motivation for PV manufacturers to engage in continuous quality improvement, as all such achievements can now be reflected in the annual report results of manufacturers. Full article
(This article belongs to the Special Issue Solar Energy Utilization and Sustainable Development)
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12 pages, 2388 KiB  
Article
New Understanding of Meta-Topolin Riboside Metabolism in Micropropagated Woody Plants
by Maroua Grira, Els Prinsen and Stefaan Werbrouck
Plants 2024, 13(9), 1281; https://doi.org/10.3390/plants13091281 - 06 May 2024
Abstract
Topolin cytokinins have emerged as valuable tools in micropropagation. This study investigates the metabolism of meta-topolin riboside (mTR) in three distinct tree species: Handroanthus guayacan and Tabebuia rosea (Bignoniaceae), and Tectona grandis (Lamiaceae). Employing labeled N15 mTR, we [...] Read more.
Topolin cytokinins have emerged as valuable tools in micropropagation. This study investigates the metabolism of meta-topolin riboside (mTR) in three distinct tree species: Handroanthus guayacan and Tabebuia rosea (Bignoniaceae), and Tectona grandis (Lamiaceae). Employing labeled N15 mTR, we unraveled the complex mechanisms underlying cytokinin homeostasis, identifying N9-glucosylation as the principal deactivation pathway. Our findings demonstrate a capacity in T. rosea and H. guayacan to reposition the hydroxyl group on the cytokinin molecule, a previously unexplored metabolic pathway. Notably, this study reveals remarkable interfamilial and interspecies differences in mTR metabolism, challenging established perspectives on the role of callus tissue in cytokinin storage. These insights not only illuminate the metabolic intricacies of mTR, a cytokinin with interesting applications in plant tissue culture, but also enhances our understanding of cytokinin dynamics in plant systems, thereby enriching the scientific discourse on plant physiology and cytokinin biology. Full article
(This article belongs to the Special Issue Plant Propagation)
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27 pages, 21112 KiB  
Article
CHANG-ES XXXI—A Decade of CHANG-ES: What We Have Learned from Radio Observations of Edge-on Galaxies
by Judith Irwin, Rainer Beck, Tanden Cook, Ralf-Jürgen Dettmar, Jayanne English, Volker Heesen, Richard Henriksen, Yan Jiang, Jiang-Tao Li, Li-Yuan Lu, Crystal Mele, Ancla Müller, Eric Murphy, Troy Porter, Richard Rand, Nathan Skeggs, Michael Stein, Yelena Stein, Jeroen Stil, Andrew Strong, Rene Walterbos, Q. Daniel Wang, Theresa Wiegert and Yang Yangadd Show full author list remove Hide full author list
Galaxies 2024, 12(3), 22; https://doi.org/10.3390/galaxies12030022 (registering DOI) - 06 May 2024
Abstract
CHANG-ES (Continuum Halos in Nearby Galaxies—an EVLA Survey) is an ambitious project to target 35 nearby disk galaxies that are edge-on to the line of sight. The orientation permits both the disk and halo regions to be studied. The observations were initially at [...] Read more.
CHANG-ES (Continuum Halos in Nearby Galaxies—an EVLA Survey) is an ambitious project to target 35 nearby disk galaxies that are edge-on to the line of sight. The orientation permits both the disk and halo regions to be studied. The observations were initially at 1.5 GHz (L-band) and 6.0 GHz (C-band) in a variety of VLA array configurations, and in all four Stokes parameters, which allowed for spatially resolved images in total intensity plus polarization. The inclusion of polarization is unique to an edge-on galaxy survey and reveals the galaxies’ halo magnetic fields. This paper will summarize the results to date, some of which are new phenomena, never seen prior to CHANG-ES. For example, we see that ‘X-type’ fields, as well as rotation measure reversals, are common features of spiral galaxies. Further observations at 3.0 GHz (S-band) as well as future scientific opportunities will also be described. Full article
(This article belongs to the Special Issue The 10th Anniversary of Galaxies: New Perspectives on Radio Surveys)
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18 pages, 642 KiB  
Article
Reliability and Detectability of Emergency Management Systems in Smart Cities under Common Cause Failures
by Thiago C. Jesus, Paulo Portugal, Daniel G. Costa and Francisco Vasques
Sensors 2024, 24(9), 2955; https://doi.org/10.3390/s24092955 (registering DOI) - 06 May 2024
Abstract
Urban areas are undergoing significant changes with the rise of smart cities, with technology transforming how cities develop through enhanced connectivity and data-driven services. However, these advancements also bring new challenges, especially in dealing with urban emergencies that can disrupt city life and [...] Read more.
Urban areas are undergoing significant changes with the rise of smart cities, with technology transforming how cities develop through enhanced connectivity and data-driven services. However, these advancements also bring new challenges, especially in dealing with urban emergencies that can disrupt city life and infrastructure. The emergency management systems have become crucial elements for enabling cities to better handle urban emergencies, although ensuring the reliability and detectability of such system remains critical. This article introduces a new method to perform reliability and detectability assessments. By using Fault Tree Markov chain models, this article evaluates their performance under extreme conditions, providing valuable insights for designing and operating urban emergency systems. These analyses fill a gap in the existing research, offering a comprehensive understanding of emergency management systems functionality in complex urban settings. Full article
(This article belongs to the Section Sensor Networks)
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21 pages, 1339 KiB  
Article
Analysis of Actual Fitness Supplement Consumption among Health and Fitness Enthusiasts
by Paolo Renzo Espeño, Ardvin Kester S. Ong, Josephine D. German, Ma. Janice J. Gumasing and Ethan S. Casas
Foods 2024, 13(9), 1424; https://doi.org/10.3390/foods13091424 - 06 May 2024
Abstract
With the rising popularity of fitness supplements, understanding the factors driving their consumption behaviors is crucial. This study investigated the actual consumption of fitness supplements utilizing the Theory of Planned Behavior (TPB), Health Belief Model (HBM), and the Theory of Effort Minimization in [...] Read more.
With the rising popularity of fitness supplements, understanding the factors driving their consumption behaviors is crucial. This study investigated the actual consumption of fitness supplements utilizing the Theory of Planned Behavior (TPB), Health Belief Model (HBM), and the Theory of Effort Minimization in Physical Activity (TEMPA) frameworks. The TPB provided insights into how attitudes, subjective norms, and perceived behavioral control influence individuals’ intentions to consume fitness supplements. Additionally, the HBM sheds light on perceived effectiveness, benefits, barriers, and health motivation related to supplement consumption. Integrating the TEMPA framework further investigated the role of effort minimization in physical activity contexts. Through an online questionnaire, data were collected from a sample of 250 fitness supplement-consuming respondents. SEM analysis revealed significant associations between behavioral intentions and attitudes, perceived behavioral control, health motivation, and controlled precursors. However, it was seen that subjective norms, perceived effectiveness, perceived benefits, and automatic precursors were deemed insignificant. The findings contribute to a comprehensive understanding of the factors shaping actual consumption behaviors, offering valuable implications for marketers, health professionals, and policymakers seeking to promote informed and responsible supplement use among health and fitness enthusiasts. Full article
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13 pages, 269 KiB  
Article
The Effect of Physical Activity and Repeated Whole-Body Cryotherapy on the Expression of Modulators of the Inflammatory Response in Mononuclear Blood Cells among Young Men
by Justyna Kusmierczyk, Magdalena Wiecek, Gabriela Wojciak, Mateusz Mardyła, Grzegorz Kreiner, Zbigniew Szygula and Jadwiga Szymura
J. Clin. Med. 2024, 13(9), 2724; https://doi.org/10.3390/jcm13092724 (registering DOI) - 06 May 2024
Abstract
Background: Series of whole-body cryotherapy (WBC) among healthy and physically active individuals can potentially reduce inflammatory response, although exact mechanisms remain unclear. Methods: The impact of whole-body cryotherapy on inflammation modulators among 28 young males, categorized as non-training (NTR, N = 10), non-training [...] Read more.
Background: Series of whole-body cryotherapy (WBC) among healthy and physically active individuals can potentially reduce inflammatory response, although exact mechanisms remain unclear. Methods: The impact of whole-body cryotherapy on inflammation modulators among 28 young males, categorized as non-training (NTR, N = 10), non-training with WBC (NTR-WBC, N = 10), and training with WBC (TR-WBC, N = 8), is investigated in this study. Over a period of eight weeks, NTR-WBC and TR-WBC subjects underwent 24 WBC treatments (−130 °C for 3 min, three times a week), examining changes in mRNA expressions of IL-1A, IL-6, IL-10, IFN-G, SIRT1, SIRT3, SOD2, GSS, and ICAM-1. Results: The received data indicate an acute inflammatory response to initial WBC (increased IL-1A, IL-6, and SIRT), with a greater effect in NTR-WBC. Subsequent sessions showed enhanced expressions of antioxidative genes in both WBC groups, particularly non-trained, suggesting improved oxidative stress adaptation. A notable decrease in ICAM-1 mRNA post-24 WBC treatments in NTR-WBC signifies a potential systemic anti-inflammatory effect. Conclusions: The findings of the study suggest that the combination of regular physical activity with WBC administered three times per week can potentially modulate inflammatory and antioxidant responses. This modulation is evidenced by changes in the expression of genes related to these processes. Full article
(This article belongs to the Section Clinical Rehabilitation)
17 pages, 1059 KiB  
Article
A Sustainable Material for Sheep’s Cheese Wedges Stored under Different Atmosphere Conditions
by Ana Isabel Nájera, Maider Murua, Olaia Martínez, Marta Albisu and Luis Javier R. Barron
Foods 2024, 13(9), 1423; https://doi.org/10.3390/foods13091423 (registering DOI) - 06 May 2024
Abstract
This study is based on the need to improve packaging sustainability in the food industry. Its aim was to assess the performance of a recyclable plastic material for semi-hard sheep’s cheese wedges packaging as an alternative to conventional non-sustainable plastic materials. Four different [...] Read more.
This study is based on the need to improve packaging sustainability in the food industry. Its aim was to assess the performance of a recyclable plastic material for semi-hard sheep’s cheese wedges packaging as an alternative to conventional non-sustainable plastic materials. Four different packaging treatments (air, vacuum, and CO2/N2 gas mixtures 50/50 and 80/20% (v/v)) were studied. Changes in gas headspace composition, sensory properties, cheese gross composition, weight loss, pH, colour, and texture profile were investigated at 5 ± 1 °C storage for 56 days. The sensory analysis indicated that vacuum packaging scored the worst in paste appearance and holes, and air atmosphere the worst in flavour; it was concluded that cheeses were unfit from day 14–21 onwards. Air and vacuum packaging were responsible for most of the significant changes identified in the texture profile analysis, and most of these happened in the early stages of storage. The colour parameters a* and b* differentiated the air packaging from the rest of the conditions. As in previous studies using conventional plastic materials, modified atmosphere packaging, either CO2/N2 50/50 or 80/20% (v/v), was the most effective preserving technique to ensure the quality of this type of cheese when comparing air and vacuum packaging treatments. Full article
(This article belongs to the Special Issue Recent Advances in Cheese and Fermented Milk Production)
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